Reactor for continuous stirring, reaction device and operation method thereof

Abstract

The invention discloses a reactor for continuous stirring, a reaction device and an operation method of the reactor, the reactor is provided with a stirrer, a feeding pipe, an air inlet pipe, an emptying pipe, a liquid discharge pipe and a mounting port group, a heat exchange coil pipe is mounted in the reactor, and two ends of the heat exchange coil pipe partially extend out of the reactor respectively; the reaction device comprises a plurality of reaction assemblies which are sequentially mounted, each reaction assembly comprises a plurality of reactors which are sequentially connected, a partition plate is mounted between every two reactors, an opening is formed in each partition plate, a discharging pipe is mounted on one side of the last reactor and is consistent with the height of an opening of each partition plate, and a sample feeding pipe is mounted on the first reactor; the discharging pipe of the last reactor in the previous reaction assembly is connected to the feeding pipe of the first reactor in the next reaction assembly; metering pumps are mounted on the feeding pipe and the sample injection pipe; the operation method comprises steps 1-4.

Description

Technical Field

[0001] The invention relates to the field of continuous stirring reaction devices, and in particular to a reactor for continuous stirring, a reaction device and an operation method thereof. Background Art

[0002] Traditional production processes of raw materials or pharmaceutical intermediates all use batch-type intermittent production in reactors. Due to the complex process and the fact that most of the processes are manually operated, it is difficult to ensure the consistency of the production results of each batch for multiple batches of production. However, in continuous production, all process parameters in the middle are steady-state and do not change with time, which can solve the above problems well.

[0003] In recent years, the rapid development of flow chemistry technology in the field of pharmaceutical production has solved many problems of traditional intermittent reactor production. For reactions containing solid catalysts or solids generated during the reaction process, since they are easily blocked in pipelines or microchannels, the best way of continuous production is currently continuous stirred tank production; nitrogen pressure and transfer pumps are currently commonly used for transferring materials between reactors. The former sometimes causes a large amount of solvent to be blown away by nitrogen, resulting in changes in the solvent ratio of the system, which may affect the reaction results. At the same time, because the solvent in the transfer pipeline is blown away, only solid materials are left, which will block the pipeline, resulting in unsmooth material transfer, and the tail gas containing a large amount of solvent will increase the environmental pressure of tail gas treatment; the latter adds moving equipment, the entire process becomes complicated, and higher requirements are put forward for the reliability of equipment operation, so the best way is not to use nitrogen pressure and gravity self-flow of transfer pumps. In addition, if the pipeline between reactors is too long, on the one hand, the possibility of blockage in the pipeline will increase, and on the other hand, since the pipeline is difficult to control the temperature, the reaction process is uncontrollable, and the uncertainty of the result increases, so the distance between reactors should be as short as possible.

[0004] For a continuous stirred tank reactor, ensuring uniform residence time of materials in the reactor is crucial to the reaction results. If the inlet and outlet are too close or the stirring and mixing is not good, some raw materials will short-circuit and flow out of the outlet before they have time to react, resulting in excessive residual raw materials. Therefore, the relative position of the inlet and outlet of the reaction materials has a great influence on the uniformity of the residence time distribution.

[0005] For different reactions, the residence time requirements of the materials in the reactor are different, which requires different liquid holding capacities in each reactor. Different liquid holding capacities correspond to discharge ports at different heights. The discharge port on the side of the traditional reactor has been processed and manufactured when it leaves the factory, and its height cannot be adjusted at will later, which limits its scope of use. Summary of the invention

[0006] The technical problem to be solved by the present invention is that the transfer of traditional solid-phase reaction liquid between reactors is prone to blockage, and the liquid holding capacity of the reactor needs to be adjusted. The present invention provides a reactor for continuous stirring, and the present invention also provides a continuous stirring reaction device. The present invention also provides an operation method of the continuous stirring reaction device. The reactor design adopts a horizontal cylindrical structure, so that the material flow distance between reactors is the shortest, avoiding the problem of easy blockage of solid materials in long-distance conveying pipelines. The design of the horizontal cylindrical structure makes the connection between reactors convenient and simple, and only flanges, fastening bolts, nuts, and partitions are needed to complete the installation and fixation. The reactor can be conveniently expanded and deleted according to needs, thereby expanding its application scenarios. The reactors are arranged up and down and front and back in a staggered manner to make full use of the space, making the structure more compact and occupying less space; the reactors are connected by baffles and weir plates, so that the macroscopic flow of logistics in the same reactor is from top to bottom or from bottom to top, effectively preventing material short circuit and making the residence time distribution more uniform. The reactor can easily adjust the liquid holding capacity of the reactor by using weir plates and side discharge ports with different opening heights, which is suitable for a variety of occasions. All reactors, metering pumps and electrical control boxes are modularly skid-mounted for easy transfer, which is used to solve the defects caused by the existing technology.

[0007] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0008] In the first aspect, a continuously stirred reactor, wherein the reactor is equipped with an agitator, a feed pipe, an air inlet pipe, a vent pipe, a drain pipe, and a mounting port group, a heat exchange coil is installed inside the reactor, and parts of the two ends of the heat exchange coil respectively protrude out of the reactor, the air inlet pipe is used to connect to the gas source, the drain pipe is installed at the bottom of the reactor for easy drainage, and the vent pipe, when in use, because the material transfer between the reactors is overflow and gravity flow, it is necessary to keep the gas phase between the reactors balanced, and the reactor venting needs to be connected in parallel to the main pipe to ensure that the pressure of all the reactors is consistent.

[0009] The above-mentioned continuous stirring reactor, wherein the reactor is a horizontal cylindrical structure, which is different from the traditional vertical cylindrical structure, is convenient for connecting multiple reactors, can expand the number of reactors, and is more compact to install. The reactor is outerly provided with a jacket, and the jacket is connected to a liquid exchange pipe, and the liquid exchange pipe is connected to the jacket heat exchange medium, and the jacket is used to maintain the temperature inside the reactor.

[0010] The above-mentioned continuous stirring reactor, wherein the installation port group includes a thermometer installation port, a pressure gauge installation port, and a liquid level gauge installation port, the thermometer installation port is used to install a thermometer, the pressure gauge installation port is used to install a pressure gauge, and the liquid level gauge installation port is installed with a liquid level gauge, the thermometer, the pressure gauge, and the liquid level gauge are respectively connected to an external PLC controller to realize data interaction, centralized display, alarm, and recording, and all process parameters can be continuously monitored online and safety interlocks can be set.

[0011] The above-mentioned continuous stirring reactor, wherein the stirrer is equipped with double-layer stirring blades and arranged inside the reactor.

[0012] In a second aspect, a continuously stirred reaction device comprises a plurality of sequentially installed reaction components, wherein the reaction components comprise a plurality of reactors of any one of the first aspects connected in sequence, a partition is installed between each of the reactors, a discharge pipe is installed on one side of the last reactor and is at the same height as the opening of the partition, and a sample injection tube is installed on the first reactor;

[0013] The discharge pipe of the last reactor in the previous reaction assembly is connected to the feed pipe of the first reactor in the next reaction assembly;

[0014] The feed pipe and the sample injection pipe are both equipped with metering pumps;

[0015] The discharge pipe of the last reactor of each reaction assembly is installed on the side, so as to be connected to the feed pipe of the next reactor through a pipeline. The height of the discharge pipe is consistent with the opening position of the baffle on each reactor in the reaction assembly, so as to ensure that the liquid holding capacity of the reactors in the same reaction assembly is consistent;

[0016] The plurality of reaction components of the reaction device are fixed on a frame and can be moved as needed. The number of layers of the reaction components and the number of reactors can be expanded or reduced according to actual needs.

[0017] The above-mentioned continuous stirring reaction device, wherein each of the reactors is connected by two flanges, the partition is installed between the two flanges, and the flange end faces between the reactors press the partition under the tension of the fastening bolts and nuts, thereby ensuring the sealing of the connection between the reactors.

[0018] In the above-mentioned continuous stirring reaction device, the partitions are baffles and weir plates, and the baffles and weir plates are arranged alternately.

[0019] The above-mentioned continuous stirring reaction device, wherein the baffle is a polytetrafluoroethylene baffle, and the weir plate is a polytetrafluoroethylene weir plate;

[0020] The PTFE baffle has a lower opening, and the hole shape is an arched notch. The opening height can be set to 1 / 10 to 1 / 5 of the diameter of the PTFE baffle, which is used to change the flow direction of the material, so that the material enters from the top and exits from the bottom, and prevents some materials from short-circuiting and directly flowing out, thereby making the material residence time distribution more uniform;

[0021] The PTFE weir plate has an upper opening, and the hole shape is the same as an arcuate notch. The height of the upper opening can be selected or adjusted according to the required liquid holding capacity. The PTFE weir plate is used to maintain a certain liquid holding capacity in the reactor.

[0022] Preferably, in the above-mentioned continuous stirring reaction device, each reaction component is vertically staggered, one reaction component is a one-step reaction, and each step reaction is provided with a plurality of continuously stirring reactors, preferably 4 reactors, and the specific number can be increased or decreased according to actual needs.

[0023] In a third aspect, a method for operating a continuous stirring reaction device comprises the following steps:

[0024] Step 1: Assemble a reaction device including multiple layers of reaction components according to requirements, and use baffles and weir plates to stagger and fix all reactors in each layer of the reaction components;

[0025] Step 2: Install the corresponding metering pump, connect the corresponding materials, nitrogen, venting pipeline, heat exchange coil medium pipeline, jacket heat exchange medium pipeline, and the instruments and motors on the reactor are connected to the PLC controller through cables;

[0026] Step 3: introducing nitrogen to inertize and replace the reactor, and then continuously introducing a small flow of nitrogen to maintain a slight positive pressure in the reactor, introducing a heat exchange medium into the jacket and the heat exchange coil of the reactor, turning on the agitators of all reactors, and starting the metering pump on the first reaction assembly to continuously flow in materials for reaction;

[0027] Step 4: When the reacted material flows from the first reaction component into the second reaction component, the corresponding metering pump is started when the liquid level meter of the first reactor in the second reaction component detects liquid level data, and the reacted material flows out from the last reactor of the last reaction component to collect the reacted material.

[0028] The above-mentioned method for operating a continuous stirring reaction device further comprises collecting all residual materials in the reactor through a drain pipe.

[0029] The technical solution provided by the above-mentioned reactor, reaction device and operation method for continuous stirring of the present invention has the following technical effects:

[0030] The reactor design with horizontal cylindrical structure makes the material flow distance between reactors the shortest, avoiding the problem of easy blockage of solid materials in long-distance conveying pipelines. The design of horizontal cylindrical structure makes the connection between reactors convenient and simple. Only flanges, fastening bolts, nuts and partitions are needed to complete the installation and fixation. The reactor can be easily expanded and deleted as needed, expanding its application scenarios. The reactor is staggered up and down, front and back, making full use of the space, making the structure more compact and occupying less space; the reactors are connected by baffles and weir plates, so that the macro flow of logistics in the same reactor is up-in and down-out or down-in and up-out, effectively preventing material short circuit and making the residence time distribution more uniform. The reactor can easily adjust the liquid holding capacity of the reactor by using weir plates and side discharge ports with different opening heights, which is suitable for a variety of occasions. All reactors, metering pumps and electrical control boxes are modularly skid-mounted for easy transfer. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a schematic structural diagram of a reactor for continuous stirring according to the present invention;

[0032] Figure 2 It is a schematic side view of the structure of a reactor for continuous stirring of the present invention;

[0033] Figure 3 This is a schematic structural diagram of a reaction device for continuous stirring according to the present invention;

[0034] Figure 4 It is a side view structural schematic diagram of a reaction device for continuous stirring of the present invention;

[0035] Figure 5 This is a schematic diagram of the connection structure between reactors in a reaction device for continuous stirring of the present invention;

[0036] Figure 6 It is a schematic diagram of the structure of the polytetrafluoroethylene baffle;

[0037] Figure 7 It is a schematic diagram of the structure of the polytetrafluoroethylene weir plate.

[0038] The reference numerals are as follows:

[0039] Reactor 100, agitator 101, feed pipe 102, air inlet pipe 103, vent pipe 104, drain pipe 105, heat exchange coil 106, jacket 107, liquid exchange pipe 108, reaction component 200, partition 201, opening 202, discharge pipe 203, sample injection pipe 204, metering pump 205, flange 206, fastening bolts 207, nuts 208. DETAILED DESCRIPTION

[0040] In order to make the technical means, creative features, objectives and effects of the invention easy to understand, the technical solutions in the embodiments of the present invention are clearly and completely described below in combination with specific diagrams. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0041] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative work shall fall within the scope of protection of the present invention.

[0042] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings in this specification are only used to match the contents disclosed in the specification so as to facilitate understanding and reading by persons familiar with this technology. They are not used to limit the conditions under which the present invention can be implemented, and therefore have no substantive technical significance. Any structural modification, change in proportion or adjustment of size, without affecting the effects and purposes that can be achieved by the present invention, should still fall within the scope of the technical contents disclosed by the present invention.

[0043] At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" cited in this specification are only for the convenience of description and are not used to limit the scope of implementation of the present invention. Changes or adjustments to their relative relationships should be regarded as the scope of implementation of the present invention without substantially changing the technical content.

[0044] like Figure 1-2 As shown, in the first aspect, the first embodiment, a continuously stirred reactor 100, wherein the reactor 100 is equipped with an agitator 101, a feed pipe 102, an air inlet pipe 103, a vent pipe 104, a drain pipe 105, and a mounting port group, a heat exchange coil 106 is installed inside the reactor 100, and both ends of the heat exchange coil 106 partially protrude out of the reactor 100, the air inlet pipe 103 is used to connect with the gas source, the drain pipe 105 is installed at the bottom of the reactor 100 for easy drainage, and the vent pipe 104, when in use, because the material transfer between the reactors 100 is overflow and gravity self-flow, it is necessary to keep the gas phase between the reactors 100 balanced, and the reactor 100 venting needs to be connected in parallel to the main pipe to ensure that the pressure of all reactors 100 is consistent;

[0045] like Figure 2As shown, the reactor 100 is a horizontal cylindrical structure, which is different from the traditional vertical cylindrical structure. It is convenient to connect multiple reactors 100, the number of reactors 100 can be expanded, and the installation is more compact. The reactor 100 is provided with a jacket 107, and the jacket 107 is connected to a liquid exchange pipe 108. The liquid exchange pipe 108 is connected to the heat exchange medium of the jacket 107, and the jacket 107 is used to maintain the temperature inside the reactor 100.

[0046] The installation port group includes a thermometer installation port, a pressure gauge installation port, and a liquid level gauge installation port. The thermometer installation port is used to install a thermometer, the pressure gauge installation port is used to install a pressure gauge, and the liquid level gauge installation port is installed with a liquid level gauge. The thermometer, pressure gauge, and liquid level gauge are respectively connected to an external PLC controller to realize data interaction, centralized display, alarm, and recording. All process parameters can be continuously monitored online and safety interlocks can be set.

[0047] The stirrer 101 is equipped with double-layer stirring blades and is disposed inside the reactor 100 to facilitate uniform stirring.

[0048] In the second aspect, the second embodiment, as Figure 3-4 As shown, a continuous stirring reaction device, wherein it comprises a plurality of reaction components 200 installed in sequence, the reaction component 200 comprises a plurality of reactors 100 of any one of the first aspect connected in sequence, a partition 201 is installed between each reactor 100, a discharge pipe 203 is installed on one side of the last reactor 100, and the discharge pipe 203 is consistent with the opening height of the partition 201, and a sample injection pipe 204 is installed on the first reactor 100;

[0049] The discharge pipe 203 of the last reactor 100 in the previous reaction assembly 200 is connected to the feed pipe 102 of the first reactor 100 in the next reaction assembly 200;

[0050] A metering pump 205 is installed on both the feed pipe 102 and the sample injection pipe 204;

[0051] The discharge pipe 203 of the last reactor 100 of each reaction assembly 200 is installed on the side, so as to be connected to the feed pipe 102 of the next reactor 100 through a pipeline. The height of the outlet pipe 203 is consistent with the position of the opening 202 of the partition 201 on each reactor 100 in the reaction assembly 200, so as to ensure that the liquid holding capacity of the reactors 100 in the same reaction assembly 200 is consistent;

[0052] The multiple reaction components 200 of the reaction device are fixed on a frame and can be moved as needed. The number of layers of the reaction components 200 and the number of reactors 100 can be expanded or reduced according to actual needs.

[0053] like Figure 5-7As shown, each reactor 100 is connected by two flanges 206, and the partition 201 is installed between the two flanges 206. The end faces of the flanges 206 between the reactors 100 press the partition 201 under the tension of the fastening bolts 207 and the nuts 208, which can ensure the sealing of the connection between the reactors 100.

[0054] The partition plate 201 is a baffle plate and a weir plate, and the baffle plate and the weir plate are arranged alternately, the baffle plate is a polytetrafluoroethylene baffle plate, and the weir plate is a polytetrafluoroethylene weir plate;

[0055] The PTFE baffle has a bottom opening with an arched notch. The opening height can be set to 1 / 10 to 1 / 5 of the diameter of the PTFE baffle. It is used to change the flow direction of the material, so that the material enters from the top and exits from the bottom, preventing some of the material from short-circuiting and directly flowing out, thereby making the material residence time distribution more uniform;

[0056] The PTFE weir plate has an upper opening, and the hole shape is also an arcuate notch. The height of the upper opening can be selected or adjusted according to the required liquid holding capacity. The PTFE weir plate is used to maintain a certain liquid holding capacity in the reactor 100.

[0057] Preferably, in the above-mentioned continuous stirring reaction device, each reaction component 200 is vertically staggered, one reaction component 200 is a one-step reaction, and each step reaction is provided with a plurality of continuously stirring reactors 100, preferably 4 reactors 100, and the specific number can be increased or decreased according to actual needs.

[0058] like Figure 3 As shown, in the specific operation, the first step of the reaction is the reaction between raw material A and raw material B, and the flow direction of the reaction liquid is: reactor R1 → reactor R2 → reactor R3 → reactor R4, and the liquid holding capacity of the reactor 100 is L1. The intermediate C' of the reaction overflows from the side outlet of the reactor R4 into the reactor R5, and reacts with the raw material C flowing into the reactor R5 in the second step. Similarly, it passes through four reactors R5-R8 in sequence, and generates an intermediate D' which flows into the reactor R9 for the third step reaction. By analogy, the raw materials A, B, C, D, and E undergo four steps of reaction and finally generate products that flow out of the reactor R16. The side view of the four-layer reactor 100 is shown in FIG. Figure 4 As shown, the reactors 100 in adjacent layers are arranged alternately up and down and front and back. Such a compact arrangement can better save space.

[0059] In a third aspect, a third embodiment, as Figure 1-7 As shown, a method for operating a continuous stirring reaction device comprises the following steps:

[0060] Step 1: Assemble a reaction device including a multi-layer reaction assembly 200 according to the requirements, and all the reactors 100 in each layer of the reaction assembly 200 are staggeredly connected and fixed by baffles and weir plates;

[0061] Step 2: Install the corresponding metering pump 205, connect the corresponding materials, nitrogen, vent pipe 104 line, heat exchange coil 106 medium pipeline, jacket 107 heat exchange medium pipeline, and connect the instruments and motors on the reactor 100 to the PLC controller through cables;

[0062] Step 3: nitrogen is introduced to replace the reactor 100 with inert gas, and then a small flow of nitrogen is continuously introduced to maintain a slight positive pressure in the reactor, a heat exchange medium is introduced into the jacket 107 and the heat exchange coil 106 of the reactor 100, the agitators 101 of all reactors 100 are turned on, and the metering pump 205 on the first reaction component 200 is started to continuously flow in materials for reaction;

[0063] Step 4: When the reacted material flows from the first reaction component 200 into the second reaction component 200, the corresponding metering pump 205 is started when the liquid level meter of the first reactor 100 in the second reaction component 200 detects liquid level data, and the reacted material flows out from the last reactor 100 of the last reaction component 200 to collect the reacted material.

[0064] The method also includes collecting all the residual materials in the reactor 100 through the drain pipe 105 .

[0065] In specific operation, a reaction device including a multi-layer reaction assembly 200 is assembled according to the requirements, and all the reactors 100 in each layer of the reaction assembly 200 are staggeredly connected and fixed by baffles and weir plates, and are installed and fixed by flanges 206, or other combination methods, such as Figure 3 As shown, the height of the arched notch of the weir plate ( Figure 7 h) is selected according to the project needs to ensure that the liquid holding capacity of each reactor 100 (R1, R2, R3, R4) in the first reaction assembly 200 is L1, the liquid holding capacity of each reactor 100 (R5, R6, R7, R8) in the second reaction assembly 200 is L2, the liquid holding capacity of each reactor 100 (R9, R10, R11, R12) in the third reaction assembly 200 is L3, and the liquid holding capacity of each reactor 100 (R13, R14, R15, R16) in the fourth reaction assembly 200 is L4;

[0066] Install the corresponding metering pump 205 ( Figure 3 P1, P2, P3, P4, P5), connect the corresponding materials, nitrogen, vent pipe 104 line, coil heat exchange medium pipeline, jacket 107 heat exchange medium pipeline, the instrument and motor equipped on the reactor 100 are connected to the PLC controller through cables;

[0067] Nitrogen is introduced to replace the inertization of the reactor 100, and then a small flow of nitrogen is continuously introduced to maintain a slight positive pressure in the reaction device. The jacket 107 and the coil of the reactor 100 are introduced with a heat exchange medium, the agitators 101 of all reactors 100 are turned on, and the metering pumps P1 and P2 are started to start the continuous flow of the reaction materials;

[0068] When the reaction material in the first reaction assembly 200 starts to flow from the last reactor R4 into the first reactor R5 in the second reaction assembly 200, the liquid level gauge of the reactor R5 automatically starts the metering pump P3 for feeding the reactor R5 in the second reaction assembly 200 when detecting the liquid level, and so on and so forth until the last reactor R16 continuously discharges the material. The material of the same step reaction will flow into the next step reactor 100 through the baffle-weir plate-baffle-drain pipe 105. The material of each reactor 100 will enter from the top and exit from the bottom or from the bottom and exit from the top, ensuring that the material has sufficient residence time in the reactor 100 and preventing the material from short-circuiting and directly flowing out of the reactor 100.

[0069] After all process parameters are stable, set the corresponding alarm interlock, continuously monitor the temperature, pressure and liquid level of all reactors 100, alarm and interlock to shut down all feed metering pumps 205 when the liquid level temperature and pressure of all reactors 100 exceed a certain range, and shut down metering pumps P1 and P2 first when the reaction is completed and shutdown is required, and then slowly open the drain pipe V4 → drain pipe V3 → drain pipe V2 → drain pipe V1 from reactor R4 to reactor R1 to empty the materials, close metering pump P3, and then slowly open the bottom valve from drain pipe V8 → drain pipe V7 → drain pipe V6 → drain pipe V5 to empty the materials, and so on. After the materials of all reactors 100 in the previous step reaction are emptied, the metering pump 205 of the next step reaction can be closed until all metering pumps 205 are closed and the materials of all reactors 100 are emptied, and finally all product liquid is collected.

[0070] In summary, a reactor, a reaction device and an operation method thereof for continuous stirring of the present invention adopts a reactor design of a horizontal cylindrical structure, so that the material flow distance between the reactors is the shortest, avoiding the problem of easy blockage of solid materials in long-distance conveying pipelines. The design of the horizontal cylindrical structure makes the connection between the reactors convenient and simple, and only flanges, fastening bolts, nuts, and partitions are needed to complete the installation and fixation. The reactor can be conveniently expanded and deleted as needed, expanding its application scenarios. The reactor is arranged in a staggered manner up and down, making the structure more compact and occupying less space; the reactors are connected by baffles and weir plates, so that the macroscopic flow of logistics in the same reactor is either up-in and down-out or down-in and up-out, effectively preventing material short circuits and making the residence time distribution more uniform. The reactor can conveniently adjust the liquid holding capacity of the reactor by using weir plates and side discharge ports with different opening heights, which is suitable for a variety of occasions. All reactors, metering pumps and electrical control boxes are modularly skid-mounted to facilitate their transfer.

[0071] The above describes the specific embodiments of the invention. It should be understood that the invention is not limited to the above specific embodiments, and the devices and structures not described in detail should be understood to be implemented in a common manner in the art; those skilled in the art can make various modifications or modifications within the scope of the claims, and make some simple deductions, deformations or substitutions, which does not affect the essence of the invention.

Claims

1. A reactor for continuous stirring, characterized in that The reactor is equipped with an agitator, a feed pipe, an air inlet pipe, a vent pipe, a liquid discharge pipe, and a mounting port group. A heat exchange coil is installed inside the reactor, and parts of both ends of the heat exchange coil protrude from the reactor.

2. A reactor for continuous stirring as claimed in claim 1, characterized in that: The reactor is a horizontal cylindrical structure. A jacket is disposed outside the reactor, and a liquid exchange pipe is connected to the jacket.

3. A reactor for continuous stirring as claimed in claim 1, characterized in that: The installation port group includes a thermometer installation port, a pressure gauge installation port, and a liquid level meter installation port.

4. A reactor for continuous stirring as claimed in claim 1, characterized in that: The stirrer is equipped with double-layer stirring blades and is arranged inside the reactor.

5. A continuous stirring reaction device, characterized in that: Comprising a plurality of reaction components installed in sequence, the reaction components comprising a plurality of reactors according to any one of claims 1 to 3 connected in sequence, a partition is installed between each of the reactors, an opening is opened on the partition, a discharge pipe is installed on one side of the last reactor, and the discharge pipe is at the same height as the opening of the partition, and a sample injection pipe is installed on the first reactor; The discharge pipe of the last reactor in the previous reaction assembly is connected to the feed pipe of the first reactor in the next reaction assembly; The feed pipe and the sample injection pipe are both equipped with metering pumps.

6. A continuous stirring reaction device as claimed in claim 5, characterized in that: Each of the reactors is connected via two flanges, and the partition is installed between the two flanges.

7. A continuous stirring reaction device as claimed in claim 6, characterized in that: The partitions are baffles and weir plates, and the baffles and weir plates are alternately arranged.

8. A continuous stirring reaction device as claimed in claim 7, characterized in that: The baffle is a polytetrafluoroethylene baffle, and the weir plate is a polytetrafluoroethylene weir plate.

9. A method for operating a continuous stirring reaction device, characterized in that: The following steps are involved: Step 1: Assemble a reaction device including multiple layers of reaction components according to requirements, and use baffles and weir plates to stagger and fix all reactors in each layer of the reaction components; Step 2: Install the corresponding metering pump, connect the corresponding materials, nitrogen, venting pipeline, heat exchange coil medium pipeline, jacket heat exchange medium pipeline, and the instruments and motors on the reactor are connected to the PLC controller through cables; Step 3: introducing nitrogen to inertize and replace the reactor, and then continuously introducing a small flow of nitrogen to maintain a slight positive pressure in the reactor, introducing a heat exchange medium into the jacket and the heat exchange coil of the reactor, turning on the agitators of all reactors, and starting the metering pump on the first reaction assembly to continuously flow in materials for reaction; Step 4: When the reacted material flows from the first reaction component into the second reaction component, the corresponding metering pump is started when the liquid level meter of the first reactor in the second reaction component detects liquid level data, and the reacted material flows out from the last reactor of the last reaction component to collect the reacted material.

10. The method for operating a continuous stirring reaction device according to claim 9, characterized in that: The method also comprises collecting all the residual materials in the reactor through a drain pipe.

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