In-vitro diagnosis equipment and temperature control adjusting device thereof
The thermal convection temperature control device solves the problem of uneven temperature changes in reaction vessels in in vitro diagnostic equipment, achieves more uniform temperature control, avoids the problem of reagent and sample deactivation, and reduces energy consumption.
Patent Information
- Application Number
- CN202411262496.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-10
- Publication Date
- 2025-01-21
AI Technical Summary
The temperature regulation devices of existing in vitro diagnostic equipment are heated or cooled through heat conduction, resulting in uneven temperature changes in the reaction vessel, affecting the activity of the reactants, and even leading to the failure of reagents and inactivation of samples.
The temperature control device adopts the thermal convection method, and through the design of the inner circulation chamber and the outer circulation chamber, the damper is used to control the air flow to achieve uniform heating and cooling of the reaction vessel.
It improves the uniformity of temperature changes in each part of the reaction vessel, avoids the problems of reagent failure and sample inactivation, and the reaction vessel is easy to take and place, and the energy consumption is low.
Smart Images
Figure CN119336087A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of in vitro diagnostic equipment, and more specifically, to a temperature control and adjustment device. In addition, the present invention also provides an in vitro diagnostic equipment comprising the temperature control and adjustment device. Background Art
[0002] In in vitro diagnostic testing, in order to meet the reaction conditions of samples and reagents and avoid sample or reagent failure, the temperature of the reactants needs to be accurately controlled so as to enter the next processing flow.
[0003] At present, the temperature control devices of in vitro diagnostic equipment mostly use heat transfer elements such as metal sheets to contact the reaction container containing the reactants, and heat or cool the reaction container through heat conduction between the heat transfer element and the reaction container. Therefore, the temperature change rate of the part of the reaction container that contacts the heat transfer element is significantly higher than the temperature change rate of other parts of the reaction container, resulting in uneven temperature changes inside the reaction container, affecting the activity of the reactants therein, and even causing reagent failure and sample inactivation, resulting in detection failure.
[0004] In summary, how to make the temperature of each part of the reaction container change evenly is a problem that needs to be solved urgently by those skilled in the art. Summary of the invention
[0005] In view of this, an object of the present invention is to provide a temperature control and adjustment device, which heats and cools a reaction container by thermal convection, thereby improving the uniformity of temperature changes in various parts of the reaction container, and the reaction container is easy to take and place and has low energy consumption.
[0006] In addition, the present invention also provides an in vitro diagnostic device comprising the above-mentioned temperature control and adjustment device.
[0007] In order to achieve the above object, the present invention provides the following technical solutions:
[0008] A temperature control and adjustment device, comprising an inner circulation chamber and an outer circulation chamber, wherein the outer circulation chamber is connected to the external environment, and the inner circulation chamber is connected to the outer circulation chamber through a movable damper, wherein the damper is used to connect or separate the inner circulation chamber and the outer circulation chamber;
[0009] The top surface of the inner circulation chamber is provided with a plurality of mounting holes for mounting the reaction container, the mounting holes are provided with clamping positioning pieces for clamping the reaction container, the inner circulation chamber is provided with a temperature detection component and a temperature adjustment component for heating the air, the temperature detection component is connected with the temperature adjustment component by signal to control the working state of the temperature adjustment component;
[0010] An internal circulation fan for enhancing airflow disturbance is arranged in the internal circulation chamber, and an external circulation fan for enhancing airflow disturbance is arranged in the external circulation chamber.
[0011] Preferably, the temperature regulating assembly includes a heat-conducting mounting plate and a heating element, the heat-conducting mounting plate is provided with a plurality of first heat-conducting blocks connected to the heating element, the first heat-conducting blocks are evenly arranged along the height direction of the heat-conducting mounting plate, the first heat-conducting blocks are in a U-shaped structure, and the internal circulation fan is arranged opposite to the U-shaped opening of the first heat-conducting block.
[0012] Preferably, both ends of the heat-conducting mounting plate are abutted against the side plates of the inner circulation chamber, and the heat-conducting mounting plate is provided with ventilation holes on both sides of the first heat-conducting block, and the ventilation holes are arranged parallel to the bottom surface of the inner circulation chamber, and the ventilation holes are evenly arranged along the height direction of the heat-conducting mounting plate.
[0013] Preferably, the temperature detection assembly includes a first temperature sensor for detecting the temperature of the first heat conducting block, a second temperature sensor for detecting the temperature of the air near the reaction container, and a third temperature sensor for detecting the temperature of the bottom of the reaction container;
[0014] A sensor mounting plate is provided above the heat-conducting mounting plate, and the sensor mounting plate is provided with a third heat-conducting block corresponding to the mounting holes one by one, the third heat-conducting block is used to contact the bottom of the reaction container, and the third temperature sensor is arranged on the third heat-conducting block.
[0015] Preferably, the third heat conductive block includes a bottom plate for contacting the bottom surface of the reaction container and a side plate for contacting the side wall of the reaction container, the side plate is extended upward from the outer edge of the bottom plate, and a sensor installation cavity for installing the third temperature sensor is provided at the bottom of the bottom plate.
[0016] Preferably, the clamping positioning member includes a clip arranged along the circumference of the mounting hole, the clip is rotatably mounted on the inner surface of the inner circulation chamber via a rotating shaft, and the rotating shaft sleeve is provided with a torsion spring for driving the clip to rotate and reset.
[0017] Preferably, the outer circulation chamber is arranged parallel to the inner circulation chamber, and the outer circulation chamber is connected to the inner circulation chamber through a partition, the height of the partition is lower than the height of the outer circulation chamber to form an air outlet of the outer circulation chamber, and the damper includes a first damper rotatably arranged at the air outlet of the outer circulation chamber;
[0018] In a natural state, the first damper abuts against the top of the partition plate under the action of its own weight to separate the outer circulation chamber from the inner circulation chamber.
[0019] Preferably, the bottom surface of the temperature adjustment component is higher than the bottom plate of the internal circulation chamber, and a second damper is rotatably provided at the bottom of the temperature adjustment component, and the free end of the second damper is relatively close to the internal circulation fan;
[0020] In a natural state, the second air door abuts against the exhaust port at the bottom of the internal circulation chamber under the action of its own weight to isolate the internal circulation chamber from the external environment.
[0021] Preferably, a third damper is provided between the partition and the temperature regulating component, and in a natural state, the third damper abuts against the top of the temperature regulating component.
[0022] An in vitro diagnostic device comprises the temperature control and adjustment device described in any one of the above items.
[0023] When the reaction container needs to be heated, the air door is controlled to separate the inner circulation chamber from the outer circulation chamber, so that the inner circulation chamber is sealed relative to the external environment, the air in the inner circulation chamber is heated by the temperature regulating component, and the flow of gas and the convection heat exchange between the airflow and the reaction container are accelerated by the inner circulation fan, so that the reaction container is heated rapidly;
[0024] When the reaction container needs to be cooled, the damper is controlled to connect the inner circulation chamber with the outer circulation chamber. At this time, the inner circulation chamber is connected with the external environment, and the heat of the reaction container is taken away by the airflow passing through the reaction container.
[0025] In the temperature control and adjustment device provided by the present invention, the reaction container is arranged in the mounting hole at the top of the inner circulation chamber, and the reaction container is convenient to take and place, and the taking and placing of the reaction container will not affect the internal temperature adjustment component and the temperature detection component;
[0026] Heating or cooling the reaction container by thermal convection, compared with heat transfer by thermal conduction, the temperature change of the reaction container is more uniform, and it is less likely to cause reagent failure and sample inactivation problems;
[0027] The inner and outer circulation chambers are connected by a movable damper. When heating, the inner and outer circulation chambers are separated to isolate the inner circulation chamber from the external environment. The volume of air to be heated is smaller, the heating speed is faster and the energy consumption is lower. When cooling, the inner and outer circulation chambers are connected to allow the inner circulation chamber to circulate with the external environment, and rapid cooling is achieved through the flow of gas between the internal and external environments.
[0028] In addition, the present invention also provides an in vitro diagnostic device comprising the above-mentioned temperature control and adjustment device. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.
[0030] Figure 1 A schematic diagram of the structure of a specific embodiment of the temperature control and adjustment device for in vitro diagnostic equipment provided by the present invention;
[0031] Figure 2 for Figure 1 A schematic diagram of the structure with the side panels of the inner circulation chamber removed;
[0032] Figure 3 for Figure 2 A schematic diagram of the main view;
[0033] Figure 4 for Figure 2 A top view schematic diagram of
[0034] Figure 5 It is a schematic diagram of the structure of the mounting holes and the clips of the mounting plate;
[0035] Figure 6 It is a schematic diagram of the structure of the temperature regulating component, the temperature detecting component and the internal circulation fan;
[0036] Figure 7 for Figure 6 A schematic diagram of the structure in another direction;
[0037] Figure 8 It is a schematic diagram of the structure of the first heat-conducting block, the second heat-conducting block and the heat-conducting mounting plate;
[0038] Fig. 9 for Figure 8 A schematic diagram of the structure in another direction;
[0039] Fig.10 is a schematic diagram of assembling the third heat conducting block and the third temperature sensor;
[0040] Fig.11 This is a schematic diagram of gas flow when the internal circulation fan is turned on;
[0041] Fig.12 Schematic diagram of gas flow when the external circulation fan is turned on.
[0042] Figure 1-Figure 12 middle:
[0043] 01-reaction container; 10-internal circulation chamber; 11-mounting plate; 111-mounting hole; 12-bottom plate; 121-exhaust port; 13-internal circulation fan; 14-partition; 20-external circulation chamber; 21-external circulation fan; 31-clamp; 32-rotating shaft; 33-torsion spring; 40-temperature adjustment component; 41-heat conductive mounting plate; 411-ventilation hole; 42-first heat conductive block; 43-second heat conductive block; 44-heating element; 45-sensor mounting plate; 51-first temperature sensor; 52-second temperature sensor; 53-third temperature sensor; 54-third heat conductive block; 61-first damper; 62-second damper; 63-third damper. DETAILED DESCRIPTION
[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0045] The core of the present invention is to provide a temperature control and adjustment device, which heats and cools the reaction container by thermal convection, thereby improving the uniformity of temperature changes in various parts of the reaction container, and the reaction container is easy to take and place, and has low energy consumption.
[0046] In addition, the present invention also provides an in vitro diagnostic device comprising the above-mentioned temperature control and adjustment device.
[0047] The temperature control and adjustment device of the in vitro diagnostic equipment provided by the present invention comprises an inner circulation chamber 10 and an outer circulation chamber 20, the outer circulation chamber 20 is connected to the external environment, the inner circulation chamber 10 is connected to the outer circulation chamber 20 through a movable damper, and the damper is used to connect or separate the inner circulation chamber 10 and the outer circulation chamber 20;
[0048] The top surface of the inner circulation chamber 10 is provided with a plurality of mounting holes 111 for mounting the reaction vessel 01, and a clamping positioning piece for clamping the reaction vessel 01 is provided in the mounting hole 111. A temperature detection component and a temperature adjustment component 40 for heating the air are provided in the inner circulation chamber 10, and the temperature detection component is connected with the temperature adjustment component 40 by signal to control the working state of the temperature adjustment component 40;
[0049] An internal circulation fan 13 for enhancing air flow disturbance is provided in the internal circulation chamber 10 , and an external circulation fan 21 for enhancing air flow disturbance is provided in the external circulation chamber 20 .
[0050] Please refer to Figure 2The reaction container 01 is installed in the mounting hole 111 of the mounting plate 11 of the inner circulation chamber 10, so that the lower half of the reaction container 01 is in contact with the airflow in the inner circulation chamber 10, and the reaction container 01 and the reagents, samples and other reactants therein are heated by thermal convection;
[0051] The above-mentioned reaction container 01 is a common reaction container for in vitro diagnosis such as a reaction chamber. The shape and size of the mounting hole 111 are determined according to the shape and size of the reaction container 01. Reagents and samples are not limited to liquids, solids and colloids. Samples include common sample forms such as blood, body fluids and swab preservation fluid.
[0052] The inner diameter of the mounting hole 111 is slightly larger than the diameter of the reaction vessel 01 to facilitate the taking and placing of the reaction vessel 01; to prevent the reaction vessel 01 from shaking in the mounting hole 111, the mounting hole 111 is provided with a clamping positioning member for clamping the reaction vessel 01 to limit its circumferential position. The clamping positioning member can be specifically set to a clip 31, a spring, an elastic buffer pad, etc.
[0053] It should be noted that in order to ensure that the axis of the reaction vessel 01 is colinear with the axis of the mounting hole 111 and to avoid one side of the reaction vessel 01 abutting against the mounting hole 111 and affecting the uniformity of the internal temperature change, the number of clamping positioning members is usually at least two, and the clamping positioning members are evenly arranged along the circumferential direction of the mounting hole 111.
[0054] For example, see Figure 5 The clamping positioning member includes a clip 31 arranged along the circumference of the mounting hole 111. The clip 31 is rotatably mounted on the inner surface of the inner circulation chamber 10 through a rotating shaft 32, and the rotating shaft 32 is sleeved with a torsion spring 33 for driving the clip 31 to rotate and reset.
[0055] When the reaction container 01 is inserted into the mounting hole 111, the reaction container 01 squeezes the clip 31, causing the clip 31 to rotate downward around the rotation axis 32, and the clip 31 is clamped by the restoring force of the torsion spring 33 to fix the reaction container 01 in the mounting hole 111; after the reaction container 01 is pulled out, the torsion spring 33 drives the clip 31 to rotate upward around the rotation axis 32 until it is restored.
[0056] A temperature regulating component 40 for heating the air is provided in the inner circulation chamber 10. By adjusting the output power of the temperature regulating component 40, the temperature and temperature rise rate of the airflow in the inner circulation chamber 10 can be adjusted, thereby adjusting the temperature gradient between the airflow and the reaction container 01, thereby affecting the temperature change rate of the reaction container 01.
[0057] The temperature adjustment component 40 mainly includes a heating element 44 and a heat conductive block. The heat conductive block is used to transfer the heat generated by the heating element 44 to the air by heat convection. The heating element 44 can be specifically set as a ceramic heating plate, a PI heating film, etc., and the heat conductive block can be set as an aluminum alloy heat conductive block, a copper heat conductive block, etc.
[0058] In order to control the working state of the temperature regulating component 40, a temperature detection component is provided in the inner circulation chamber 10. The temperature measured by the temperature detection component can be used to perform negative feedback regulation on the temperature regulating component 40 to accurately control the temperature of the reaction container 01, avoid the problem of reagent failure and sample inactivation caused by untimely feedback regulation, and reduce energy consumption.
[0059] The specific type and model of the sensor in the temperature detection component can be referred to the temperature control component settings of existing in vitro diagnostic equipment according to actual production needs, and will not be repeated here.
[0060] In order to speed up the flow of gas in the inner circulation chamber 10 and form heat convection between the heat conductive block and the air, and between the air and the reaction container 01, rather than transferring heat through heat conduction, an inner circulation fan 13 is provided in the inner circulation chamber 10. By adjusting the rotation speed of the inner circulation fan 13, the air flow velocity in the inner circulation chamber 10 can be adjusted, thereby affecting the heat transfer efficiency of the heat convection.
[0061] The type, model and installation method of the internal circulation fan 13 are determined according to the needs in actual production and will not be elaborated here.
[0062] When the temperature of the reaction container 01 needs to be lowered, if the temperature adjustment component 40 is used for cooling and lowering, the temperature adjustment component 40 is required to be able to heat the air and to cool the air, which results in a complex structure, high equipment cost, and high energy consumption.
[0063] Therefore, the inner circulation chamber 10 is usually connected to the external environment for ventilation and heat dissipation, and the heat of the reaction container 01 is taken away by the exchange of internal and external gases, thereby reducing the temperature of the reaction container 01 and the reactants therein.
[0064] The outer circulation chamber 20 is connected to the external environment, so by controlling the damper to connect the inner circulation chamber 10 with the outer circulation chamber 20, the inner circulation chamber 10 can be connected to the external environment; at this time, the external gas enters the inner circulation chamber 10 through the outer circulation chamber 20, passes through the surface of the reaction container 01, takes away the heat of the reaction container 01, and then is discharged through the inner circulation chamber 10 or the outer circulation chamber 20.
[0065] It should be noted that if the gas is discharged from the outer circulation chamber 20, at least two dampers are preferably provided between the inner and outer circulation chambers, one damper is used to control the intake of air from the outer circulation chamber 20 to the inner circulation chamber 10, and the other damper is used to control the exhaust of air from the inner circulation chamber 10 to the outer circulation chamber 20;
[0066] If the gas is discharged from the inner circulation chamber 10, an exhaust port 121 should be provided in the inner circulation chamber 10, and a seal or a one-way valve should be provided at the exhaust port 121 to ensure that the inner circulation chamber 10 is in a closed state when the reaction container 01 is heated, so as to avoid heat loss caused by the exchange of internal and external gases at the exhaust port 121.
[0067] In order to speed up the ventilation and heat dissipation efficiency, an external circulation fan 21 is provided in the external circulation chamber 20. The external circulation fan 21 can significantly improve the internal and external gas exchange efficiency through active heat dissipation, thereby improving the heat exchange efficiency between the reaction container 01 and the airflow, and realizing rapid cooling of the reaction container 01.
[0068] In this embodiment, the reaction container 01 is arranged in the mounting hole 111 at the top of the inner circulation chamber 10, and the reaction container 01 is convenient to take and place, and the taking and placing of the reaction container 01 will not affect the internal temperature adjustment component 40 and the temperature detection component;
[0069] The reaction container 01 is heated or cooled by heat convection. Compared with heat transfer by heat conduction, the temperature change of the reaction container 01 is more uniform, and it is less likely to cause reagent failure and sample inactivation.
[0070] The inner and outer circulation chambers are connected by a movable damper. When heating, the inner and outer circulation chambers are separated to isolate the inner circulation chamber 10 from the external environment. The volume of air to be heated is smaller, the heating speed is faster and the energy consumption is lower. When cooling, the inner and outer circulation chambers are connected to allow the inner circulation chamber 10 to circulate with the external environment, and rapid cooling is achieved through the flow of gas between the internal and external environments.
[0071] On the basis of the above embodiments, the structure of the temperature adjustment component 40 is defined. The temperature adjustment component 40 includes a heat-conducting mounting plate 41 and a heating element 44. The heat-conducting mounting plate 41 is provided with a plurality of first heat-conducting blocks 42 connected to the heating element 44. The first heat-conducting blocks 42 are evenly arranged along the height direction of the heat-conducting mounting plate 41. The first heat-conducting blocks 42 are U-shaped, and the internal circulation fan 13 is arranged opposite to the U-shaped opening of the first heat-conducting block 42.
[0072] Please refer to Figure 8A plurality of first heat-conducting blocks 42 are evenly arranged on the heat-conducting mounting plate 41 along the height direction. The first heat-conducting blocks 42 are in a U-shaped structure. The internal circulation fan 13 is arranged opposite to the U-shaped opening of the first heat-conducting block 42, which can not only shorten the distance from the internal circulation fan 13 to the first heat-conducting block 42, but also increase the contact area between the first heat-conducting block 42 and the airflow, thereby effectively improving the heat transfer efficiency between the first heat-conducting block 42 and the airflow.
[0073] Preferably, in order to further improve the heating efficiency of the temperature regulating component 40 for the air, a second heat conducting block 43 can be provided outside the first heat conducting block 42, and the second heat conducting block 43 is a U-shaped structure. The first heat conducting block 42 is arranged in the U-shaped opening of the second heat conducting block 43. By increasing the output power of the temperature regulating component 40, the heating efficiency of the temperature regulating component 40 for the air is improved.
[0074] The first heat-conducting block 42 is preferably arranged in the center of the second heat-conducting block 43. The materials and sizes of the first heat-conducting block 42 and the second heat-conducting block 43, the horizontal spacing between the first heat-conducting block 42 and the second heat-conducting block 43, the spacing between two adjacent first heat-conducting blocks 42, and the spacing between two adjacent second heat-conducting blocks 43 are determined according to actual production needs and will not be elaborated here.
[0075] In addition, the distribution of the first heat conductive block 42 and the second heat conductive block 43 can also be adjusted according to the actual flow state of the air in the internal circulation chamber 10. At this time, the distance between two adjacent first heat conductive blocks 42 may be different, and the distance between two adjacent second heat conductive blocks 43 may also be different.
[0076] In order to facilitate the assembly of the internal circulation fan 13, the internal circulation fan 13 is preferably arranged between the top plate and the bottom plate of the temperature adjustment component 40 through a fan mounting plate. This is not only beneficial to the alignment of the internal circulation fan 13 and the U-shaped opening of the first heat conductive block 42, and ensures the installation accuracy of the two, but the fan mounting plate can also cooperate with the temperature adjustment component 40 to guide the airflow in the internal circulation chamber 10.
[0077] Based on the above examples, please refer to Figure 4 Both ends of the heat-conducting mounting plate 41 can be arranged to abut against the side plates of the inner circulation chamber 10. The heat-conducting mounting plate 41 is provided with ventilation holes 411 on both sides of the first heat-conducting block 42. The ventilation holes 411 are arranged parallel to the bottom surface of the inner circulation chamber 10, and the ventilation holes 411 are evenly arranged along the height direction of the heat-conducting mounting plate 41.
[0078] Therefore, the ventilation holes 411 can guide the flow direction of the air on both sides, making it convenient for the heat conductive block to heat the airflow in a limited space; the shape, size and spacing of the ventilation holes 411 are determined according to the volume of the internal circulation chamber 10 in actual production.
[0079] On the basis of the above embodiment, in order to accurately reflect the current temperature of the inner circulation chamber 10, the temperature detection component includes a first temperature sensor 51 for detecting the temperature of the first heat conducting block 42, a second temperature sensor 52 for detecting the temperature of the air near the reaction container 01, and a third temperature sensor 53 for detecting the temperature at the bottom of the reaction container 01;
[0080] A sensor mounting plate 45 is provided above the heat-conducting mounting plate 41 . The sensor mounting plate 45 is provided with a third heat-conducting block 54 corresponding to the mounting hole 111 . The third heat-conducting block 54 is used to contact the bottom of the reaction container 01 . The third temperature sensor 53 is provided on the third heat-conducting block 54 .
[0081] The first temperature sensor 51 is disposed on the first heat conducting block 42 and is used to detect the temperature of the first heat conducting block 42. Fig. 9 As shown;
[0082] The second temperature sensor 52 can be disposed on the bottom surface of the mounting plate 11 or on the sensor mounting plate 45 to detect the temperature of the air near the mounting hole 111. To avoid interference between the second temperature sensor 52 and the clamping positioning member during installation and use, the second temperature sensor 52 is preferably disposed on the sensor mounting plate 45. Figure 6 and Figure 7 As shown;
[0083] Considering that the bottom of the reaction container 01 is not a planar structure, directly setting the third temperature sensor 53 in contact with the bottom of the reaction container 01 is not only difficult to ensure effective contact between the two, but also difficult to accurately measure the temperature of the reaction container 01. Therefore, the third heat conductive block 54 is set to contact the bottom of the reaction container 01, and the third temperature sensor 53 is set on the third heat conductive block 54. The temperature of the bottom of the reaction container 01 is detected by detecting the temperature of the third heat conductive block 54.
[0084] There is no restriction on the specific types and models of the first temperature sensor 51 , the second temperature sensor 52 and the third temperature sensor 53 , as long as their temperature detection range and detection accuracy meet the temperature control requirements and are easy to install and stable to assemble.
[0085] In this embodiment, temperature sensors are used to respectively detect the temperature of the first heat conductive block 42, the air temperature near the reaction container 01, and the temperature of the reaction container 01. Compared with only setting a temperature sensor to detect the temperature of the reaction container 01, it is not only convenient to perform timely feedback adjustment on the temperature adjustment component 40 to avoid excessive temperature rise rate of the reaction container 01, but also more accurate and energy-saving control of the temperature of the reaction container 01, and it is also beneficial to determine the fault location when there is a problem with temperature adjustment to achieve rapid troubleshooting.
[0086] Preferably, please refer to Fig.10The third heat conductive block 54 includes a bottom plate for contacting the bottom surface of the reaction container 01 and a side plate for contacting the side wall of the reaction container 01. The side plate is extended upward from the outer edge of the bottom plate, and a sensor installation cavity for installing the third temperature sensor 53 is provided at the bottom of the bottom plate.
[0087] The center of the bottom plate of the third heat conducting block 54 is located on the axis of the mounting hole 111. The bottom plate diameter is determined according to the bottom diameter of the reaction container 01. The side plate is preferably configured as an arc plate to increase the contact area between the side plate and the side wall of the reaction container 01.
[0088] In order to ensure the contact area between the third heat conducting block 54 and the reaction container 01 so that the temperatures of the two are the same, the number of side plates is preferably at least two, and the side plates are evenly distributed along the circumferential direction of the bottom plate.
[0089] On the basis of the above embodiment, the outer circulation chamber 20 is arranged parallel to the inner circulation chamber 10, and the outer circulation chamber 20 is connected to the inner circulation chamber 10 through the partition 14, the height of the partition 14 is lower than the height of the outer circulation chamber 20, so as to form an air outlet of the outer circulation chamber 20, and the damper includes a first damper 61 rotatably arranged at the air outlet of the outer circulation chamber 20;
[0090] In a natural state, the first damper 61 abuts against the top of the partition plate 14 under the action of its own weight to separate the outer circulation chamber 20 from the inner circulation chamber 10 .
[0091] It should be noted that, in order to achieve ventilation and heat exchange with the external environment when the inner and outer circulation chambers are connected, the inner circulation chamber 10 is provided with a one-way valve or an exhaust port 121 sealed by a movable seal.
[0092] Please refer to Figure 3 , the outer circulation chamber 20 is connected to the inner circulation chamber 10 through the partition 14, and the height of the partition 14 is lower than the height of the outer circulation chamber 20, so as to form an air outlet at the top of the outer circulation chamber 20;
[0093] The first damper 61 is disposed at the air outlet of the outer circulation chamber 20. The rotating shaft of the first damper 61 is disposed close to the outer plate of the outer circulation chamber 20, or is directly disposed on the outer plate of the outer circulation chamber 20. Therefore, in a natural state where both the inner and outer circulation fans are not working, the free end of the first damper 61 abuts against the top of the partition plate 14, thereby separating the inner and outer circulation chambers. Fig.11 shown.
[0094] When the internal circulation fan 13 is working, the force of the airflow on the first damper 61 has a vertical downward component, further pressing the first damper 61 against the partition 14 to ensure that the internal circulation chamber 10 is completely separated from the external circulation chamber 20;
[0095] When the external circulation fan 21 is working, the force of the airflow on the first damper 61 has a vertical upward component, which can overcome the gravity of the first damper 61 and separate the free end of the first damper 61 from the partition 14, thereby opening the air outlet of the external circulation chamber 20 and connecting the internal circulation chamber 10 and the external circulation chamber 20.
[0096] In this embodiment, the first damper 61 is arranged at the air outlet of the outer circulation chamber 20, and the self-weight of the first damper 61 is utilized to make it abut against the partition 14 in a natural state to separate the inner circulation chamber 10 and the outer circulation chamber 20, and the airflow is utilized to push the first damper 61 to separate from the partition 14 and connect the inner circulation chamber 10 and the outer circulation chamber 20. Compared with providing a separate power mechanism to control the rotation of the first damper 61, it not only has a simple structure, is easy to assemble, and has low equipment cost, but also reduces the overall energy consumption of the temperature control adjustment device.
[0097] On the basis of the above embodiment, the air outlet structure of the internal circulation chamber 10 is defined, the bottom surface of the temperature adjustment component 40 is higher than the bottom plate 12 of the internal circulation chamber 10, and the bottom of the temperature adjustment component 40 is rotatably provided with a second damper 62, and the free end of the second damper 62 is arranged relative to the rotating shaft end close to the internal circulation fan 13;
[0098] In a natural state, the second air door 62 abuts against the exhaust port 121 at the bottom of the internal circulation chamber 10 under the action of its own weight to isolate the internal circulation chamber 10 from the external environment.
[0099] Please refer to Figure 3 In a natural state, the second damper 62 rotates downward around the axis under the action of its own weight, so that the second damper 62 abuts against the exhaust port 121 of the internal circulation chamber 10, isolating the internal circulation chamber 10 from the external environment, and at this time, the direction of the second damper 62 is opposite to the flow direction of the air flow inside the internal circulation chamber 10 when the internal circulation fan 13 is working. Therefore, when the internal circulation fan 13 is working, the wind pressure of the internal air flow further presses the second damper 62 against the exhaust port 121. Fig.11 shown.
[0100] When the external circulation fan 21 is working, the second damper 62 rotates upward around the axis under the push of wind pressure, so that the second damper 62 is separated from the exhaust port 121 of the internal circulation chamber 10. Fig.12 shown.
[0101] In this embodiment, the second damper 62 is used to seal the exhaust port 121 of the internal circulation chamber 10, and the wind pressure is used to push the second damper 62 to separate from the exhaust port 121. Compared with driving the seal to move relative to the exhaust port 121 by a power mechanism, the structure is simple, the assembly is convenient, and the cost and energy consumption are lower.
[0102] Based on the above embodiment, a third air door 63 is provided between the partition 14 and the temperature regulating component 40. In a natural state, the third air door 63 abuts against the top of the temperature regulating component 40 to cooperate with the inner wall of the inner circulation chamber 10 to separate the inner circulation chamber 10.
[0103] The third air door 63 is disposed between the partition plate 14 and the temperature adjustment assembly 40 to guide the air flow direction. Fig.11 When the inner circulation fan 13 is working, the third damper 63 is pushed open by the wind pressure. At this time, the gas between the inner circulation chamber 10 and the temperature regulating component 40 can enter between the inner circulation fan 13 and the inner circulation chamber 10 through the inner circulation fan 13 after being heated by the temperature regulating component 40, and then rise to enter the top of the inner circulation chamber 10, and after flowing through the reaction container 01 in the reverse direction for heat exchange, re-enter between the inner circulation chamber 10 and the temperature regulating component 40.
[0104] Please refer to Fig.12 When the external circulation fan 21 is working, the wind pressure cooperates with the weight of the third air door 63 to press it tightly above the temperature adjustment component 40. Restricted by the third air door 63, the air flow entering from the external circulation chamber 20 passes through the reaction container 01 for heat exchange, enters between the internal circulation chamber 10 and the temperature adjustment component 40, and then is discharged through the exhaust port 121 at the bottom of the internal circulation chamber 10.
[0105] In this embodiment, the third damper 63 is provided to prevent the airflow entering the outer circulation chamber 20 from being discharged directly without passing through the reaction container 01, thereby improving the heat exchange effect between the airflow and the reaction container 01 under the premise of a certain incoming flow rate;
[0106] Furthermore, the third damper 63 is driven by its own weight and wind pressure, and no additional power mechanism is required, so the structure is simple and the installation is convenient.
[0107] In addition to the above-mentioned temperature control and adjustment device, the present invention also provides an in vitro diagnostic device including the temperature control and adjustment device disclosed in the above-mentioned embodiment. For the structures of other parts of the in vitro diagnostic device, please refer to the prior art and will not be described in detail herein.
[0108] It should be noted that the first heat conductive block 42, the second heat conductive block 43 and the third heat conductive block 54, the first temperature sensor 51, the second temperature sensor 52 and the third temperature sensor 53, and the first damper 61, the second damper 62 and the third damper 63 mentioned in the present application document are only used to distinguish the difference in position and do not contain any limitation on the order.
[0109] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.
[0110] The in vitro diagnostic device and the temperature control device provided by the present invention are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.
Claims
1. A temperature control device, characterized in that: The invention comprises an inner circulation chamber (10) and an outer circulation chamber (20), wherein the outer circulation chamber (20) is in communication with the external environment, and the inner circulation chamber (10) is in communication with the outer circulation chamber (20) via a movable damper, wherein the damper is used to connect or separate the inner circulation chamber (10) and the outer circulation chamber (20); The top surface of the inner circulation chamber (10) is provided with a plurality of mounting holes (111) for mounting a reaction container (01), and a clamping positioning piece for clamping the reaction container (01) is provided in the mounting hole (111). A temperature detection component and a temperature adjustment component (40) for heating air are provided in the inner circulation chamber (10), and the temperature detection component is connected to the temperature adjustment component (40) by signal so as to control the working state of the temperature adjustment component (40); An internal circulation fan (13) for enhancing airflow disturbance is provided in the internal circulation chamber (10), and an external circulation fan (21) for enhancing airflow disturbance is provided in the external circulation chamber (20).
2. The temperature control device according to claim 1, characterized in that: The temperature regulating assembly (40) comprises a heat-conducting mounting plate (41) and a heating element (44); the heat-conducting mounting plate (41) is provided with a plurality of first heat-conducting blocks (42) connected to the heating element (44); the first heat-conducting blocks (42) are evenly arranged along the height direction of the heat-conducting mounting plate (41); the first heat-conducting blocks (42) are in a U-shaped structure; and the internal circulation fan (13) is arranged opposite to the U-shaped opening of the first heat-conducting blocks (42).
3. The temperature control device according to claim 2, characterized in that: Both ends of the heat-conducting mounting plate (41) are in contact with the side plates of the inner circulation chamber (10); the heat-conducting mounting plate (41) is provided with ventilation holes (411) on both sides of the first heat-conducting block (42); the ventilation holes (411) are arranged parallel to the bottom surface of the inner circulation chamber (10); and the ventilation holes (411) are evenly arranged along the height direction of the heat-conducting mounting plate (41).
4. The temperature control device according to claim 2, characterized in that: The temperature detection component comprises a first temperature sensor (51) for detecting the temperature of the first heat-conducting block (42), a second temperature sensor (52) for detecting the temperature of air near the reaction container (01), and a third temperature sensor (53) for detecting the temperature of the bottom of the reaction container (01); A sensor mounting plate (45) is provided above the heat-conducting mounting plate (41); the sensor mounting plate (45) is provided with a third heat-conducting block (54) corresponding one-to-one to the mounting hole (111); the third heat-conducting block (54) is used to contact the bottom of the reaction container (01); and the third temperature sensor (53) is provided on the third heat-conducting block (54).
5. The temperature control device according to claim 4, characterized in that: The third heat conducting block (54) comprises a bottom plate for contacting the bottom surface of the reaction container (01) and a side plate for contacting the side wall of the reaction container (01), the side plate extending upward from the outer edge of the bottom plate, and a sensor mounting cavity for mounting the third temperature sensor (53) is provided at the bottom of the bottom plate.
6. The temperature control device according to any one of claims 1 to 5, characterized in that: The clamping positioning member comprises a clamping piece (31) arranged along the circumference of the mounting hole (111); the clamping piece (31) is rotatably mounted on the inner surface of the inner circulation chamber (10) via a rotating shaft (32); and the rotating shaft (32) is sleeved with a torsion spring (33) for driving the clamping piece (31) to rotate and reset.
7. The temperature control device according to any one of claims 1 to 5, characterized in that: The outer circulation chamber (20) is arranged parallel to the inner circulation chamber (10), and the outer circulation chamber (20) is connected to the inner circulation chamber (10) via a partition (14), the height of the partition (14) is lower than the height of the outer circulation chamber (20) to form an air outlet of the outer circulation chamber (20), and the air door comprises a first air door (61) rotatably arranged at the air outlet of the outer circulation chamber (20); In a natural state, the first damper (61) abuts against the top of the partition plate (14) under the action of its own weight, so as to separate the outer circulation chamber (20) from the inner circulation chamber (10).
8. The temperature control device according to claim 7, characterized in that: The bottom surface of the temperature adjustment component (40) is higher than the bottom plate (12) of the internal circulation chamber (10); a second air door (62) is rotatably provided at the bottom of the temperature adjustment component (40); and a free end of the second air door (62) is arranged relatively close to the internal circulation fan (13); In a natural state, the second air door (62) abuts against the air outlet (121) at the bottom of the internal circulation chamber (10) under the action of its own weight, so as to isolate the internal circulation chamber (10) from the external environment.
9. The temperature control device according to claim 8, characterized in that: A third air door (63) is provided between the partition plate (14) and the temperature adjustment component (40); in a natural state, the third air door (63) abuts against the top of the temperature adjustment component (40).
10. An in vitro diagnostic device, characterized in that: It comprises the temperature control and adjustment device according to any one of claims 1 to 9.