Composition for preventing and treating respiratory tract infection of livestock and poultry and preparation method thereof

Abstract

The invention relates to the field of medicine, in particular to a composition for preventing and treating respiratory tract infection of livestock and poultry and a preparation method of the composition. Firstly, one part of honeysuckle, one part of isatis root and one part of liquorice are taken, and water is added for decoction twice; 8 times of water is added for the first time, 6 times of water is added for the second time, a slight boiling state is kept for 2 hours after the water is boiled each time, and then the water is filtered by a 200-mesh filter screen while the water is hot. And merging the two filtrates, fully and uniformly mixing, concentrating until each milliliter of the filtrate is equivalent to 1g of the crude medicine, and then refrigerating for 24 hours. Filtering with a paper pulp plate, complementing the loss caused by operations such as filtering, and refrigerating for 24 hours again. After the refrigeration is finished, adding the second composition into the first component according to the proportion of 3%, uniformly mixing, sterilizing for 30 minutes by adopting circulating steam, and then carrying out quality inspection and filling to finally obtain a finished product.

Description

Technical Field

[0001] The invention relates to the field of medicine, and in particular to a composition for preventing and treating respiratory tract infection in livestock and poultry and a preparation method thereof. Background Art

[0002] Respiratory diseases of livestock and poultry refer to various diseases that affect the respiratory function of livestock and poultry. In modern livestock and poultry farming, the incidence of respiratory infections remains high due to factors such as high breeding density, increased difficulty in environmental control, and the diversity and variability of pathogens.

[0003] These diseases not only damage the lung tissue of animals, leading to destruction of alveolar structure and ventilation dysfunction, but may also cause systemic reactions, such as fever, which will affect the metabolic balance of livestock and poultry, causing them to lack appetite and thus lose weight. The growth and development of diseased livestock and poultry are hindered, and production performance is greatly reduced. For example, laying hens have significantly reduced egg production, broilers grow slowly, and dairy cows have reduced milk production. What is more serious is that some respiratory infections are highly contagious and spread rapidly in farms, which may cause a large number of livestock and poultry to become ill or even die, causing huge economic losses to farmers.

[0004] Traditional prevention and treatment methods often have certain limitations. The use of chemical antibacterial drugs alone may lead to the development of pathogen resistance, and long-term use may also leave residues in livestock and poultry products, affecting food safety. Although some single Chinese medicine preparations are relatively safe, they may not be ideal in terms of comprehensive effects such as antibacterial, anti-inflammatory, and antiviral. Therefore, there is an urgent need for a pharmaceutical composition and a corresponding preparation method that can effectively prevent and treat respiratory tract infections in livestock and poultry, and has the advantages of high safety and low resistance to drug resistance. Summary of the invention

[0005] The present invention provides a composition for preventing and treating respiratory tract infection in livestock and poultry and a preparation method thereof, aiming to solve the above-mentioned disadvantages.

[0006] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0007] The composition for preventing and treating respiratory tract infection in livestock and poultry comprises 1-4 parts of tartaric acid, 0.25-0.8 parts of a third component and 40-60 parts of anhydrous glucose as an auxiliary material.

[0008] Furthermore, 1 part of tartaric acid, 0.25 parts of the third component, and 40 parts of auxiliary material anhydrous glucose.

[0009] Furthermore, it also includes a second composition; the second composition contains 1-3 parts of honeysuckle, 1-3 parts of isatis root, and 1-3 parts of licorice.

[0010] Preferably, a second composition is also included; the second composition contains 1 part of honeysuckle, 1 part of isatis root, and 1 part of liquorice.

[0011] The preparation method of the composition for preventing and treating respiratory tract infection in livestock and poultry comprises the following steps:

[0012] First, 1 part of tartaric acid, 0.25 parts of trimethoprim and 40 parts of anhydrous glucose are pulverized together and passed through a 60-mesh sieve.

[0013] Next, tartaric acid, the third component and an equal amount of auxiliary materials are taken, diluted and mixed using an equal amount incremental dilution method, and then sieved through a 60-mesh screen three times to obtain an intermediate mixture.

[0014] Finally, the intermediate mixture is uniformly mixed with the remaining auxiliary materials and passed through an 80-mesh fine sieve three times to obtain the first component.

[0015] Furthermore, for the second composition, 1 portion of each of honeysuckle, isatis root, and liquorice was first taken and decocted twice, 8 times the amount of water was added for the first time, and 6 times the amount of water was added for the second time, and each time the water was kept in a slightly boiling state for 2 hours after boiling, and then filtered with a 200-mesh filter while hot.

[0016] The two filtrates were combined and mixed thoroughly, concentrated to a concentration of 1 g of the original drug per ml, and then refrigerated for 24 hours.

[0017] After filtering with a pulp board, the loss caused by filtering and other operations is supplemented, and the mixture is refrigerated for 24 hours again. After the refrigeration is completed, the second composition is added to the first component at a ratio of 3%, and after mixing evenly, it is sterilized by circulating steam for 30 minutes, followed by quality inspection and filling, and finally the finished product is obtained.

[0018] The beneficial effects of the present invention are:

[0019] The composition of Example 2 not only contains antibacterial ingredients such as tartaric acid and trimethoprim, but also contains Chinese medicinal ingredients such as honeysuckle, isatis root, and licorice. Among them, phenanthene in isatis root can inhibit viral replication, chlorogenic acid in honeysuckle can inhibit bacterial growth, and glycyrrhizin in licorice can reduce inflammatory reactions. Multiple ingredients cooperate with each other to exert the comprehensive effects of clearing heat and detoxifying, antibacterial and anti-inflammatory, achieving a full range of effects from antiviral, antibacterial to anti-inflammatory on respiratory tract infections in livestock and poultry, and improving the treatment effect.

[0020] In addition, the overall composition has a high safety while exerting a broad-spectrum anti-pathogen effect. When used in accordance with the prescribed usage and dosage, it has less toxic side effects on livestock and poultry, and can effectively treat diseases while ensuring the health and growth and development of livestock and poultry.

[0021] Furthermore, whether it is the first component of Example 1 or the complete composition of Example 2, the method of use is to add it to drinking water for livestock and poultry to drink freely. This method of administration is simple and easy, and is convenient to operate and implement during the breeding process. It does not require complicated administration equipment or technology, and reduces the difficulty of manual operation and the stress response of livestock and poultry. DETAILED DESCRIPTION

[0022] In order to make the contents of the present invention more clearly understood, the technical solutions in the embodiments of the present invention are described clearly and completely.

[0023] Embodiment 1

[0024] A composition for preventing and treating respiratory tract infections in livestock and poultry, comprising a first component;

[0025] The first component consists of 1-4 parts of tartaric acid, 0.25-0.8 parts of trimethoprim and 40-60 parts of anhydrous glucose as an auxiliary material.

[0026] Preferably, the first component is composed of 1 part of tartaric acid, 0.25 parts of trimethoprim, and 40 parts of auxiliary material anhydrous glucose.

[0027] Preparation method:

[0028] First, 1 part of tartaric acid, 0.25 parts of trimethoprim and 40 parts of anhydrous glucose are pulverized together and passed through a 60-mesh sieve.

[0029] Next, tartaric acid, trimethoprim and an equal amount of auxiliary materials are diluted and mixed using an equal incremental dilution method, and then sieved through a 60-mesh screen three times to obtain an intermediate mixture.

[0030] Finally, the intermediate mixture is uniformly mixed with the remaining auxiliary materials and passed through an 80-mesh fine sieve three times to obtain the first component.

[0031] Dosage and Administration: Add the first component to drinking water and use it for 5 consecutive days as a course of treatment.

[0032] Embodiment 2

[0033] On the basis of the first component of Example 1, a second composition is added; the second composition comprises 1-3 parts of honeysuckle, 1-3 parts of isatis root, and 1-3 parts of liquorice. Preferably, 1-3 parts of honeysuckle, 1-3 parts of isatis root, and 1-3 parts of liquorice.

[0034] Preparation method:

[0035] For the second composition, first take 1 portion of honeysuckle, radix isatidis, and licorice, and boil them twice. Add 8 times the amount of water for the first time and 6 times the amount of water for the second time. Keep the water slightly boiling for 2 hours each time after boiling, and then filter it with a 200-mesh filter while it is hot.

[0036] The two filtrates were combined and mixed thoroughly, concentrated to a concentration of 1 g of the original drug per ml, and then refrigerated for 24 hours.

[0037] After filtering with a pulp board, the loss caused by filtering and other operations is supplemented, and the mixture is refrigerated for 24 hours again. After the refrigeration is completed, the second composition is added to the first component at a ratio of 3%, and after mixing evenly, it is sterilized by circulating steam for 30 minutes, followed by quality inspection and filling, and finally the finished product is obtained.

[0038] Dosage and Administration:

[0039] Poultry: Add 1ml / 2L water twice a day for free drinking, for 3-5 days.

[0040] Pharmacological analysis

[0041] 1. Antiviral effect:

[0042] Phenanthrone in Radix Isatidis can inhibit viral replication. Viral infections are common in livestock and poultry respiratory infections, such as influenza viruses. Phenanthrone may prevent the proliferation of viruses in livestock and poultry respiratory epithelial cells by interfering with viral nucleic acid synthesis, protein assembly and other processes, thereby reducing viral damage to respiratory tissues and relieving infection symptoms.

[0043] 2. Antibacterial effect:

[0044] Chlorogenic acid in honeysuckle has the ability to inhibit bacterial growth. Respiratory tract infections are often accompanied by bacterial infections, such as Escherichia coli, Pasteurella, etc. Chlorogenic acid may act on the bacterial cell wall, cell membrane or metabolic enzyme system, destroy the structural integrity of the bacteria or interfere with its normal metabolism, inhibit the growth and reproduction of bacteria, reduce the number of bacteria in the respiratory tract, and reduce the inducing factors of inflammatory response.

[0045] 3. Anti-inflammatory Effects:

[0046] Glycyrrhizin in licorice can reduce inflammatory responses. During respiratory infections, the body's immune response can trigger inflammation, leading to congestion, edema, and increased secretions of the respiratory mucosa. Glycyrrhizin may regulate the secretion of inflammatory cytokines, such as inhibiting the excessive production of tumor necrosis factor-α and interleukin-6, and reduce the infiltration of inflammatory cells, thereby alleviating respiratory inflammatory symptoms and promoting the repair of respiratory tissues.

[0047] 4. Synergy and safety:

[0048] The various ingredients in this composition work synergistically. Tartaric acid and trimethoprim may cooperate with the antibacterial and antiviral effects of honeysuckle and isatis through other antibacterial mechanisms to enhance the inhibitory effect on pathogens. At the same time, the anti-inflammatory effect of glycyrrhizin helps to reduce the overall inflammatory response and is beneficial to the recovery of the body. Moreover, the composition is highly safe. Under the recommended usage and dosage, it has less toxic and side effects on livestock and poultry, and can effectively treat respiratory infections while ensuring the health and growth and development of livestock and poultry.

[0049] In summary, the following advantages are obtained. The composition of Example 2 not only contains antibacterial ingredients such as tartaric acid and trimethoprim, but also adds Chinese medicinal materials such as honeysuckle, isatis root, and licorice. Among them, phenanthene in isatis root can inhibit viral replication, chlorogenic acid in honeysuckle can inhibit bacterial growth, and glycyrrhizin in licorice can reduce inflammatory reactions. Multiple ingredients cooperate with each other to exert the comprehensive effects of clearing heat and detoxifying, antibacterial and anti-inflammatory, and achieve a full range of effects from antiviral, antibacterial to anti-inflammatory on respiratory tract infections of livestock and poultry, thereby improving the therapeutic effect. In addition, while the overall composition exerts a broad-spectrum anti-pathogen effect, it has a high safety. When used in accordance with the prescribed usage and dosage, it has less toxic and side effects on livestock and poultry, and can effectively treat diseases while ensuring the health and growth of livestock and poultry. Furthermore, whether it is the first component of Example 1 or the complete composition of Example 2, its use method is to add it to drinking water for livestock and poultry to drink freely. This method of administration is simple and easy to implement, convenient for operation and implementation during the breeding process, without the need for complex administration equipment or technology, and reduces the difficulty of manual operation and the stress response of livestock and poultry.

[0050] After the above-mentioned trimethoprim is fed to laying hens, residues may be left in the eggs. In order to avoid residues in the eggs, it may be replaced by at least one of Lactobacillus acidophilus, carvacrol and thymol, which constitute the third component. Natural ingredients such as carvacrol and thymol and microbial Lactobacillus acidophilus will not produce drug residues in eggs.

[0051] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A composition for preventing and treating respiratory tract infections in livestock and poultry, characterized in that: include: 1-4 parts of tartaric acid The third component 0.25-0.8 parts Auxiliary material: 40-60 parts of anhydrous glucose. The third component consists of at least one of Lactobacillus acidophilus, carvacrol and thymol.

2. The composition for preventing and treating respiratory tract infections in livestock and poultry according to claim 1, characterized in that: 1 part tartaric acid The third component 0.25 parts Auxiliary material: 40 parts of anhydrous glucose.

3. The composition for preventing and treating respiratory tract infections in livestock and poultry according to claim 1, characterized in that: Also included is a second composition; the second composition comprises: 1-3 servings of honeysuckle 1-3 servings of Isatis root 1-3 parts of licorice.

4. The composition for preventing and treating respiratory tract infections in livestock and poultry according to claim 2, characterized in that: Also included is a second composition; the second composition comprises: 1 piece of honeysuckle 1 serving of Isatis root 1 part licorice.

5. A method for preparing a composition for preventing and treating respiratory tract infections in livestock and poultry, comprising the following steps: First, 1 part of tartaric acid, 0.25 parts of the third component and 40 parts of anhydrous glucose are pulverized together and passed through a 60-mesh sieve. Next, tartaric acid, the third component and an equal amount of auxiliary materials are taken, diluted and mixed using an equal amount incremental dilution method, and then sieved through a 60-mesh screen three times to obtain an intermediate mixture. Finally, the intermediate mixture is uniformly mixed with the remaining auxiliary materials and passed through an 80-mesh fine sieve three times to obtain the first component.

6. The method for preparing the composition for preventing and treating respiratory tract infections in livestock and poultry according to claim 5, characterized in that: The following steps are also included: For the second composition, first take 1 portion of honeysuckle, radix isatidis, and licorice, and boil them twice. Add 8 times the amount of water for the first time and 6 times the amount of water for the second time. Keep the water slightly boiling for 2 hours each time after boiling, and then filter it with a 200-mesh filter while it is hot. The two filtrates were combined and mixed thoroughly, concentrated to a concentration of 1 g of the original drug per ml, and then refrigerated for 24 hours. After filtering with a pulp board, the loss caused by filtering and other operations is supplemented, and the mixture is refrigerated for 24 hours again. After the refrigeration is completed, the second composition is added to the first component at a ratio of 3%, and after mixing evenly, it is sterilized by circulating steam for 30 minutes, followed by quality inspection and filling, and finally the finished product is obtained.