Preparation device and preparation method of protamine sulfate injection

Abstract

The invention relates to the technical field of injection preparation, in particular to a protamine sulfate injection preparation device and method.The protamine sulfate injection preparation device comprises a preparation base, an overturning frame and a fixing disc, the overturning frame is fixedly installed at the center of one end of the top of the preparation base through bolts, and a V-shaped rotating groove is formed in the center of one side in the overturning frame; and overturning plates are connected to the positions, on the two sides of the V-shaped rotating groove, of the overturning frame through limiting bases, a lifting frame is arranged on one side in the overturning frame, a first screw rod is movably connected into the lifting frame, and a fixing block is fixedly installed at the top of one end in the preparation base through bolts. The preparation cylinder is used for loading the preparation liquid after descending and is matched with the degerming filter cylinder for filtering the preparation liquid after ascending and overturning, the design is ingenious, the connection is stable and reasonable, the degerming filter cylinder is rotated in the process of being far away from the fixed disc, the degerming filter loading is completed again after the process of being close to the fixed disc, multi-group filtration is completed in cycles, and the design is reasonable and ingenious.

Description

Technical Field

[0001] The invention relates to the technical field of injection preparation, and in particular to a protamine sulfate injection preparation device and a preparation method. Background Art

[0002] Protamine is a polycationic peptide sulfate extracted from fish sperm cells. It has a strong alkaline group and can combine with strongly acidic heparin in the body to form a stable complex, thereby making heparin lose its anticoagulant ability. Since this substance can combine with some proteins and polypeptides, it can be used to form complexes with insulin, corticotropin, etc. to prepare long-acting injections. The production of protamine sulfate mainly includes three steps: extraction, separation and refining. Among them, the extraction of protamine is generally to mince the milt of mature male fish, add dilute acetic acid solution, separate the condensed sperm nucleus, and then use organic solvent for precipitation, then add inorganic acid and stir for a certain period of time, discard the waste residue, and use organic solvent to precipitate the extract to obtain a crude product of protamine inorganic acid salt. In the separation step, the most commonly used method is to repeatedly precipitate and dissolve with organic solvent and sulfuric acid to gradually remove different impurities.

[0003] At present, during sterilization filtration, the prepared liquid needs to be transferred and filtered back and forth multiple times, and multiple filtrations are completed in sterilization filter cartridges equipped with different pore sizes. For example, in a preparation method of protamine sulfate injection with the authorized public number CN107469070B, the protamine sulfate injection obtained by the method and its application are filtered using a multi-stage sterilization filter cartridge. The operation in the back-and-forth transfer filtration is relatively cumbersome, and the operator needs to hold the prepared liquid to complete the pouring, which is labor-intensive. The added time in the back-and-forth transfer filtration is also easily affected by environmental interference. Summary of the invention

[0004] In order to overcome the deficiencies of the prior art, the present invention provides a device and a method for preparing protamine sulfate injection.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions: comprising a preparation base, a turning frame arranged at one end of the top of the preparation base, and a fixed disk movably located at the outer center of the top of the preparation base, the turning frame is fixedly installed at the center of the top end of the preparation base by bolts, a V-shaped rotating groove is opened at the center of one side of the inner part of the turning frame, and a turning plate is connected to the turning frame on both sides of the V-shaped rotating groove through a limiting base, a lifting frame is arranged at one side of the inner part of the turning frame, a first screw is movably connected in the lifting frame, a fixed block is fixedly installed at the top of one end of the inner part of the preparation base by bolts, a second screw is movably connected between the preparation base and the fixed block through a bearing, and a rotating assembly for rotating the fixed disk is arranged in the preparation base, wherein the rotating assembly comprises:

[0006] A movable block moves on the second screw rod, and movable plates are fixedly installed at both ends of one side of the bottom of the fixed plate by bolts. The movable block thread penetrates the second screw rod, and the center of one side of the top of the movable block is fixedly installed on the bottom end of one of the movable plates by bolts. A rotating disk is movably arranged at the top center of the fixed plate, and four groups of sterilizing filter cartridges with different apertures are evenly installed at the center of the rotating disk. A first gear is meshed and connected on one side of the rotating disk on the fixed plate, and a rotating shaft is fixedly installed at the center of the bottom end of the first gear by bolts, and the bottom of the rotating shaft penetrates the bearing on the fixed plate and extends to the preparation base;

[0007] A second gear is movable in the preparation base, a movable cylinder is movably connected to the bottom end of the rotating shaft in the preparation base, the second gear is fixedly installed on the bottom end of the movable cylinder by bolts, a fixing plate is fixedly installed on one side of the rotating shaft in the preparation base by bolts, a fixing frame is movably connected to one side of the fixing plate, a limiting column is movably arranged in the fixing frame, the movable cylinder is connected to the inside of the limiting column through the central movable part of the bearing, and an arc-shaped positioning rod is fixedly installed on one side of the limiting column by bolts;

[0008] A first limit plate is fixedly installed on the preparation base by bolts on the other side of the rotating shaft, a second limit plate is fixedly installed on the preparation base by bolts on one side of the first limit plate, a support rod is fixedly installed on the preparation base by bolts on one side between the first limit plate and the second limit plate, and a rack block movably meshed with the second gear is fixedly installed between the bottom ends of the support rods by bolts.

[0009] As a preferred technical solution of the present invention, a T-shaped slide groove is provided at the center of one side of the limit base, a T-shaped slider is slidably connected to the limit base in the T-shaped slide groove, one side of the flip plate is fixedly installed on the top of the T-shaped slider by bolts, a flip plate is fixedly installed at the center of the flip plate by bolts, a rotating column is movably connected to the center of the rotating disk by the bearing, a flip column is movably arranged in the V-shaped rotating groove, and a rotating plate is fixedly installed between the rotating column and the rotating column by bolts;

[0010] An electric telescopic rod is fixedly installed on the top of the rotating column by bolts, and a preparation cylinder is fixedly installed on the top of the electric telescopic rod by bolts, and a liquid inlet and a liquid outlet with a rotating cover are respectively provided at both ends of one side of the top of the preparation cylinder, and a supporting groove is provided on one side of the flip frame, and the electric telescopic rod moves in the supporting groove.

[0011] A servo motor is fixedly installed at the bottom of one end of the preparation base by bolts, the bottom end of the first screw rod passes through the flip frame and extends to the output end of the servo motor in the preparation base, and a first bevel gear is fixedly installed at the outer periphery of the bottom end of the first screw rod by bolts, and a second bevel gear meshing with the first bevel gear is fixedly installed at the outer periphery of one side of the fixing block by bolts on the second screw rod;

[0012] A lifting block is threadedly connected to the first screw rod in the lifting frame, and the center of one side of the lifting block is connected to one side of the flip plate through a lifting rod. A movable groove is opened on one side of the lifting frame, and the lifting rod movably passes through the movable groove. Limit rods are fixedly installed on both sides of the second screw rod on the preparation base by bolts, and both ends of the movable block movably pass through the limit rods.

[0013] As a preferred technical solution of the present invention, an annular base is fixedly installed at the top center of the fixed disk by bolts, an annular groove is opened at the top center of the annular base, an annular block is slidably connected to the annular groove on the annular base, and the top of the annular block is fixedly installed on the bottom of the rotating disk by bolts, and the movable plate on the movable block movably penetrates the groove opened on the preparation base;

[0014] A fixed slide groove is provided on the other side of the top of the preparation base, and a fixed slider is slidably connected to the preparation base in the fixed slide groove. The bottom end of the other movable plate is fixedly installed at the top center of the fixed slider by bolts, and the rotating shaft movably passes through the limiting groove provided on the top of the preparation base.

[0015] A fixing groove is provided on one side of the fixing plate, a sliding block is slidably connected to the fixing groove on the fixing plate, one side of the fixing frame is fixedly installed on the sliding block by bolts, one side of the fixing frame is fixedly installed with a limit seat by bolts, a limit pin is connected to the limit seat by a limit spring, and the limit pin movably extends through and extends into a limit hole provided on the limit column.

[0016] As a preferred technical solution of the present invention, an arc groove is provided on one side of the top of the movable cylinder, an arc strip matching the size of the arc groove is fixedly installed on the outer periphery of the bottom end of the rotating shaft, and the arc strip movably passes through the arc groove, a positioning groove is provided on one side of the interior of the fixed frame, and the fixed frame is connected to the two ends of one side of the limiting column through the positioning blocks in the positioning groove, and the arc positioning rod movably passes through and extends to the outside of the fixed frame.

[0017] A first stop groove for resisting the movement of the arc-shaped positioning rod is formed on one side of the first limit plate, and a second stop groove for resisting the movement of the arc-shaped positioning rod is formed on one side of the second limit plate, and the second stop groove is located on the bottom side of the first stop groove, and the arc-shaped positioning rod moves in the first stop groove and the second stop groove.

[0018] As a preferred technical solution of the present invention, a method for preparing a protamine sulfate injection preparation device comprises the following steps:

[0019] Step 1: Dissolve the protamine sulfate extract in water to obtain a preparation solution. At this time, the liquid inlet on the preparation cylinder is at the bottom center of the sterilizing filter cylinder of the fixed plate. Pour the preparation solution into the sterilizing filter cylinder with a larger pore size. Use the sterilizing filter cylinder to filter and sterilize the preparation solution into the preparation cylinder, thereby completing one filtration;

[0020] Step 2: After completing the filtration of a sterilizing filter cartridge, the servo motor rotates to drive the first screw to rotate, and the lifting block on the first screw moves upward in the lifting frame. The lifting block moves the flip plate on the limit base upward through the lifting rod and the movable groove. During the rising process, the flip plate rotates the rotating column on the flip disk through the V-shaped rotating groove, the flip column and the rotating plate, thereby driving the preparation cartridge on the electric telescopic rod to flip during the rising process. At this time, the liquid outlet on the preparation cartridge faces downward;

[0021] Step three: During the rotation of the servo motor, the first bevel gear and the second bevel gear are meshed to drive the second screw on the fixed block to rotate synchronously, and the movable block on the second screw realizes reciprocating motion in the limit rod. During the movement of the movable block, the fixed plate will be driven to move away from the flip frame through the slot and the movable plate. In the process of moving away from the flip frame, the second gear at the bottom of the rotating shaft meshes and rotates with the rack block under the support rod, and the second gear drives the first gear to rotate. The meshing of the first gear drives the rotating disk on the annular base to rotate synchronously, so that the rotating disk switches to the next aperture sterilizing filter cylinder to the bottom end of the preparation cylinder. At this time, the arc-shaped positioning rod in the fixed frame is lowered by the second stop groove of the second limit plate, and the limit pin rod in the limit seat supports the limit column to descend and limit, so that the second gear descends and cannot engage with the rack block;

[0022] Step 4: Switch to the sterilizing filter cylinder with another pore size to the liquid outlet under the preparation cylinder, extend the preparation cylinder to the top of the fixed plate away from the flip frame through the electric telescopic rod, so that the liquid outlet of the preparation cylinder is located at the top center of the sterilizing filter cylinder, open the preparation cylinder and pour the preparation solution after the first filtration into the sterilizing filter cylinder;

[0023] Step 5: The servo motor reverses the movement, causing the preparation cylinder to flip and descend in the flip frame to reset to the position in step 1. At the same time, the fixed plate realizes the return movement through the movable block and the second screw. The movable cylinder under the rotating shaft and the second gear descend without engaging with the rack block during the return process. The sterilizing filter cylinder containing the preparation solution on the fixed plate does not rotate, but is directly driven to the top of the preparation cylinder. Then, the switch under the sterilizing filter cylinder is turned on to allow the filtered preparation solution to enter the preparation cylinder again, completing the second group of sterilizing filtration. At the same time, the arc positioning rod enters the first retaining groove of the first limit plate, causing the arc positioning rod to reset and rise again, waiting for the completion of the movement and rotation of the next group of sterilizing filter cylinders.

[0024] Compared with the prior art, the present invention can achieve the following beneficial effects:

[0025] 1. The lifting block moves the flip plate on the limit base upward through the lifting rod and the movable groove. During the rising process, the flip plate rotates the rotating column on the flip disk through the V-shaped rotating groove, the flip column and the rotating plate, so that the preparation cylinder on the electric telescopic rod flips during the rising process, so that the top of the preparation cylinder flips to discharge liquid and the bottom flips to inlet liquid.

[0026] 2. During the movement of the movable block, the fixed plate will be driven to move away from the flip frame through the slot and the movable plate. In the process of moving away from the flip frame, the second gear at the bottom of the rotating shaft meshes with the rack block under the support rod to rotate, so that the first gear meshes and drives the rotating disk on the annular base to rotate synchronously, and the rotating disk sterilization filter cartridge is rotated and switched for convenient re-filtration.

[0027] 3. The arc-shaped positioning rod in the fixed frame realizes lifting movement in the first stop groove and the second stop groove, and synchronously drives the limit column in the fixed frame to lift and lower. The limit pin rod in the limit seat supports the limit column for lifting and lowering, realizes whether the second gear and the rack block are actively engaged, completes the intermittent rotation movement of the rotating disk, and realizes the automatic rotation adjustment of the position of the sterilization filter cartridge during the movement.

[0028] 4. During the reverse movement of the servo motor, the fixed plate realizes the return movement through the movable block and the second screw, and the preparation cylinder returns to the bottom center of the sterilization filtration cylinder to achieve the effect of sterilization filtration again. The arc positioning rod enters the first retaining groove of the first limit plate, so that the arc positioning rod resets and rises again. The structural connection is stable, achieving an automated and efficient filtration effect.

[0029] 5. The preparation liquid is loaded in the preparation cylinder while it is descending, and then it rises and flips over to filter the preparation liquid in conjunction with the sterilization filter cylinder. The design is ingenious and the connection is stable and reasonable. The sterilization filter cylinder is rotated during the process of the fixed disk moving away, and the loading of the sterilization filtration is completed again after the process of approaching. Multiple groups of filtration are completed in a cycle, and the design is reasonable and ingenious. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The overall structure of the present invention is shown in FIG. Figure 1 ;

[0031] Figure 2 The overall structure of the present invention is shown in FIG. Figure 2 ;

[0032] Figure 3 For the present invention Figure 1 Schematic diagram of the internal structure of the base Figure 1 ;

[0033] Figure 4 For the present invention Figure 1 Schematic diagram of the internal structure of the base Figure 2 ;

[0034] Figure 5 For the present invention Figure 4 Schematic diagram of the internal structure of the middle tilt frame;

[0035] Figure 6 For the present invention Figure 3 Schematic diagram of the connection structure of the first limiting plate;

[0036] Figure 7 For the present invention Figure 6 Schematic diagram of the second gear connection structure;

[0037] Figure 8 For the present invention Figure 7 Schematic diagram of the connection structure of the middle limit column;

[0038] Fig. 9 For the present invention Figure 1 Schematic diagram of the connection structure of the middle lifting frame;

[0039] Fig.10 For the present invention Figure 8 A schematic enlarged diagram of the structure in the middle.

[0040] Among them: 10, preparation base; 11, servo motor; 12, fixed slide; 13, fixed slider; 20, flip frame; 21, V-shaped rotating groove; 22, limit base; 23, flip plate; 24, T-shaped slide; 25, T-shaped slider; 26, flip plate; 27, rotating column; 28, flip column; 29, rotating plate; 30, fixed plate; 31, rotating plate; 32, sterilizing filter cartridge; 33, first gear; 34, rotating shaft; 35, annular base; 36, annular groove; 37, annular block; 38, limit groove; 39, arc strip; 40, lifting frame; 41, first screw; 42, first bevel gear; 43, lifting block; 44, lifting rod; 45, movable groove; 50, fixed block; 51, second Screw; 52, movable block; 53, movable plate; 54, second bevel gear; 55, limit rod; 56, slot; 60, second gear; 61, movable cylinder; 62, fixed plate; 63, fixed frame; 64, arc groove; 65, limit column; 66, arc positioning rod; 67, fixed groove; 68, sliding block; 70, first limit plate; 71, second limit plate; 72, support rod; 73, rack block; 74, first stop groove; 75, second stop groove; 80, electric telescopic rod; 81, preparation cylinder; 82, liquid inlet; 83, liquid outlet; 84, support groove; 90, bearing; 91, limit seat; 92, limit spring; 93, limit pin; 94, limit hole; 95, positioning groove; 96, positioning block. DETAILED DESCRIPTION

[0041] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work all belong to the protection scope of the present invention. The experimental methods in the following embodiments, unless otherwise specified, are conventional methods, and the materials, reagents, etc. used in the following embodiments, unless otherwise specified, can all be obtained from commercial channels.

[0042] Embodiment: Figure 1 , Figure 3 , Figure 4 , Figure 6 , Figure 7 and Figure 8As shown, it includes a preparation base 10, a turning frame 20 arranged at one end of the top of the preparation base 10, and a fixed plate 30 that is movable at the center of the outer side of the top of the preparation base 10. The turning frame 20 is fixedly installed at the center of the top end of the preparation base 10 by bolts. A V-shaped rotating groove 21 is opened at the center of one side of the inner part of the turning frame 20. The turning frame 20 is connected with a turning plate 23 on both sides of the V-shaped rotating groove 21 through a limiting base 22. A lifting frame 40 is arranged on one side of the turning frame 20. For the lifting and turning effect of the preparation tube 81, a first screw 41 is movably connected in the lifting frame 40. A fixed block 50 is fixedly installed at the top of one end of the inner part of the preparation base 10 by bolts. A second screw 51 is movably connected between the preparation base 10 and the fixed block 50 through a bearing 90. A rotating component for the fixed plate 30 is arranged in the preparation base 10, wherein the rotating component includes:

[0043] The movable block 52 is movable on the second screw rod 51, and movable plates 53 are fixedly installed at both ends of the bottom side of the fixed disk 30 by bolts. The movable block 52 thread penetrates the second screw rod 51, and the center of the top side of the movable block 52 is fixedly installed on the bottom end of one of the movable plates 53 by bolts, driving the fixed disk 30 to achieve reciprocating motion back and forth. A rotating disk 31 is movably arranged at the center of the top of the fixed disk 30, and four groups of sterilizing filter cartridges 32 with different apertures are evenly installed at the center of the rotating disk 31. The top of the sterilizing filter cartridge 32 is provided with a feed hopper, a bottom With a rotary closing valve, the pore sizes of the sterilizing filter cartridge 32 are all different, and the pore size of the sterilizing filter cartridge 32 is between 0.24μm and 0.2μm. A first gear 33 is meshed and connected on one side of the rotating disk 31 on the fixed disk 30. A rotating shaft 34 is fixedly installed at the center of the bottom end of the first gear 33 by bolts. The bottom of the rotating shaft 34 passes through the bearing 90 on the fixed disk 30 and extends to the preparation base 10. The rotating shaft 34 is used to drive the first gear 33 to rotate synchronously, and then drive the rotating disk 31 to perform intermittent rotation during the movement.

[0044] A second gear 60 is movable in the preparation base 10, and a movable cylinder 61 is movably connected to the bottom end of the rotating shaft 34 in the preparation base 10. The second gear 60 is fixedly installed on the bottom end of the movable cylinder 61 by bolts. The movable cylinder 61 is used to perform telescopic movement under the rotating shaft 34, so that the second gear 60 is meshed with the rack block 73. A fixed plate 62 is fixedly installed on one side of the rotating shaft 34 in the preparation base 10 by bolts. A fixed frame 63 is movably connected to one side of the fixed plate 62. The movable cylinder 61 is telescopically moved at the bottom end of the rotating shaft 34 by the fixed frame 63. A limiting column 65 is movably arranged in the fixed frame 63. The movable cylinder 61 is connected to the movable cylinder 61 at the central movable part of the bearing 90 inside the limiting column 65. An arc-shaped positioning rod 66 is fixedly installed on one side of the limiting column 65 by bolts. The arc-shaped positioning rod 66 is used to adjust and support the distance of the movable cylinder 61.

[0045] A first limit plate 70 is fixedly installed on the preparation base 10 on the other side of the rotating shaft 34 by bolts, a second limit plate 71 is fixedly installed on the preparation base 10 on one side of the first limit plate 70 by bolts, a support rod 72 is fixedly installed on the preparation base 10 on one side between the first limit plate 70 and the second limit plate 71 by bolts, a rack block 73 movably meshed with the second gear 60 is fixedly installed between the bottom ends of the support rods 72 by bolts, the second gear 60 is movably meshed with the rack block 73, so that the first gear 33 on the rotating shaft 34 performs intermittent rotational motion on the rotating disk 31.

[0046] See also Figure 2 , Figure 4 , Figure 5 and Fig. 9 A T-shaped slide groove 24 is provided at the center of one side of the limiting base 22, a T-shaped slider 25 is slidably connected in the T-shaped slide groove 24 on the limiting base 22, one side of the flip plate 23 is fixedly installed on the top of the T-shaped slider 25 by bolts, a flip plate 26 is fixedly installed at the center of the flip plate 23 by bolts, a rotating column 27 is movably connected to the center of the rotating disk 31 through a bearing 90, a flip column 28 is movably provided in the V-shaped rotating groove 21, and a rotating plate 29 is fixedly installed between the rotating columns 27 and the rotating columns 27 by bolts, so as to drive the rotating motion during the lifting process;

[0047] An electric telescopic rod 80 is fixedly installed on the top of the rotating column 27 by bolts, and a preparation cylinder 81 is fixedly installed on the top of the electric telescopic rod 80 by bolts, and a liquid inlet 82 and a liquid outlet 83 with a rotating cover are respectively provided at both ends of one side of the top of the preparation cylinder 81 to realize the in and out of the preparation liquid, and a supporting groove 84 is provided on one side of the flip frame 20, and the electric telescopic rod 80 moves in the supporting groove 84 and moves through it to realize the flipping movement.

[0048] A servo motor 11 is fixedly installed at the bottom of one end of the preparation base 10 by bolts, the bottom end of the first screw 41 passes through the flip frame 20 and extends to the output end of the servo motor 11 in the preparation base 10, and a first bevel gear 42 is fixedly installed on the outer periphery of the bottom end of the first screw 41 by bolts, and a second bevel gear 54 meshingly connected with the first bevel gear 42 is fixedly installed on the outer periphery of one side of the fixing block 50 by bolts on the second screw 51, so as to realize synchronous reciprocating motion, and achieve the effect of being far away from lifting and close to filtering;

[0049] In the lifting frame 40, a lifting block 43 is threadedly connected to the first screw rod 41, and the center of one side of the lifting block 43 is connected to one side of the flip plate 26 through a lifting rod 44. A movable groove 45 is opened on one side of the lifting frame 40, and the lifting rod 44 movably penetrates the movable groove 45. Limit rods 55 are fixedly installed on both sides of the second screw rod 51 on the preparation base 10 by bolts, and both ends of the movable block 52 are movably penetrated in the limit rods 55, and are movable through them to achieve stable back and forth motion.

[0050] See also Figure 2 , Figure 3 and Figure 4 An annular base 35 is fixedly installed at the top center of the fixed disk 30 by bolts, and an annular groove 36 is opened at the top center of the annular base 35. An annular block 37 is slidably connected in the annular groove 36 on the annular base 35, and the top of the annular block 37 is fixedly installed on the bottom of the rotating disk 31 by bolts, so that the rotating disk 31 can perform stable intermittent rotation. The movable plate 53 on the movable block 52 is movable and penetrates the groove 56 opened on the preparation base 10, and the structure is simple and stable.

[0051] A fixed slide groove 12 is provided on the other side of the top of the preparation base 10, and a fixed slider 13 is slidably connected to the preparation base 10 in the fixed slide groove 12. The bottom end of another movable plate 53 is fixedly installed at the top center of the fixed slider 13 by bolts to achieve stable back and forth movement of the fixed disk 30. The rotating shaft 34 movably passes through the limit groove 38 provided on the top of the preparation base 10, and the connection is through-connected, and the structure is stable.

[0052] A fixing groove 67 is provided on one side of the fixing plate 62, and a sliding block 68 is slidably connected to the fixing plate 62 in the fixing groove 67. One side of the fixing frame 63 is fixedly installed on the sliding block 68 by bolts, and one side of the fixing frame 63 is fixedly installed with a limiting seat 91 by bolts. The limiting seat 91 is connected with a limiting pin rod 93 by a limiting spring 92, and the limiting pin rod 93 movably extends through and extends to a limiting hole 94 provided on the limiting column 65 to realize positioning support.

[0053] See also Figure 6 , Figure 7 , Figure 8 and Fig.10 An arc groove 64 is provided on one side of the top of the movable cylinder 61, and an arc strip 39 that matches the size of the arc groove 64 is fixedly installed on the outer periphery of the bottom end of the rotating shaft 34, and the arc strip 39 movably penetrates the arc groove 64, and a positioning groove 95 is provided on one side of the inner side of the fixed frame 63. The positioning block 96 in the positioning groove 95 is connected to the two ends of one side of the limiting column 65 in the fixed frame 63, and the arc positioning rod 66 movably penetrates and extends to the outside of the fixed frame 63.

[0054] A first retaining groove 74 is provided on one side of the first limiting plate 70 for resisting the movement of the arc-shaped positioning rod 66, and the arc-shaped positioning rod 66 enters the first retaining groove 74 for downward movement, and a second retaining groove 75 is provided on one side of the second limiting plate 71 for resisting the movement of the arc-shaped positioning rod 66, and the arc-shaped positioning rod 66 moves upward after entering the second retaining groove 75, and the second retaining groove 75 is located on the bottom side of the first retaining groove 74, and the arc-shaped positioning rod 66 moves in the first retaining groove 74 and the second retaining groove 75, and performs lifting and lowering movements between the first retaining groove 74 and the second retaining groove 75, and the structure is simple and stable.

[0055] Specifically, the preparation process includes the following steps:

[0056] Weighing: after calculating the feed amount, weigh protamine sulfate (feed amount of protamine sulfate (kg) = 262500000 units / raw material titer / 1000000), weigh disodium edetate (0.25 kg for the first time, 0.375 kg for the second time), sodium dihydrogen phosphate (0.05 kg for the first time, 0.075 kg for the second time), sodium chloride (1.125 kg for the first time, 1.575 kg for the second time), and activated carbon (0.375 kg);

[0057] Concentrated preparation: S1. The water for injection used for preparation should not be more than 12 hours old;

[0058] S2. Add 50% of the prepared amount of water for injection into the liquid preparation tank I, and cool the interlayer to 25±5℃ through cooling water;

[0059] S3, add 50% of the total volume of sodium chloride into the liquid preparation tank I, set the stirring frequency to 20 Hz, and stir for 10 minutes to dissolve evenly;

[0060] S4, filter the sodium chloride solution (Cobetter 0.22 μm polyvinylidene fluoride filter element) into the liquid preparation tank II to 40% of the total volume;

[0061] S5. Add the weighed protamine sulfate into the liquid preparation tank II, set the stirring frequency to 20 Hz, and stir for 10 minutes to dissolve;

[0062] S6. Add 40% of the total volume of disodium edetate and sodium dihydrogen phosphate to the liquid preparation tank II, set the stirring frequency to 20 Hz, and stir for 10 minutes to dissolve;

[0063] S7. Detect the pH value and adjust the pH value to 2.95±0.15 with 1mol / L sodium hydroxide and 1mol / L hydrochloric acid. Cool the interlayer of liquid preparation tank II to 12±3℃ and keep it warm for 19±7 hours. Filter (Cobetter 0.22μm polyvinylidene fluoride filter) into liquid preparation tank III;

[0064] S8, add 60% of the total volume of disodium edetate and sodium dihydrogen phosphate to the liquid preparation tank III, set the stirring frequency to 20 Hz, and stir for 10 minutes to dissolve;

[0065] S9, test the pH value, and adjust the pH value to 3.15±0.15 with 0.5 mol / L sodium hydroxide and 0.5 mol / L hydrochloric acid;

[0066] S10, add 70% of the prepared amount of water for injection into the liquid preparation tank I;

[0067] S11. Add 70% of the prepared amount of water for injection into the liquid preparation tank I and cool it down to 25±5℃. Add 70% of the total volume of sodium chloride into the liquid preparation tank I, set the stirring frequency to 20Hz, stir for 10 minutes to dissolve evenly, top up the residual liquid in the liquid preparation tank II, and filter the sodium chloride solution through (liquid preparation tank I Cobetter 0.22μm polyvinylidene fluoride filter element, liquid preparation tank II Cobetter 0.22μm polyvinylidene fluoride filter element) into the liquid preparation tank III, and the volume of the liquid in the liquid preparation tank III reaches the final volume (the difference shall not exceed ±0.5kg);

[0068] S12, add activated (180℃, constant temperature for more than 4 hours) activated carbon according to the dosage (250,000 ml) 0.2%, set the stirring frequency to 20Hz, stir and adsorb for 30 minutes. Use cartridge filters (0.45μm titanium rod, code LW161, Cobetter 0.22μm polyvinylidene fluoride filter element, code LW159, Cobetter 0.22μm polyvinylidene fluoride filter element, code LW160) for primary filtration (primary filtrate returns to the liquid preparation tank for at least 5 minutes) to the dilution tank in the F-diluting room.

[0069] Among them, the pressure of the drug solution filtered by the filter shall not exceed 0.55MPa. During the steam sterilization process, the sterilization temperature is 121℃, the time is 30 minutes, the air intake pressure should be greater than 0.1MPa, and the pressure difference of the pressure gauge before and after filtration of the cartridge filter shall not exceed 0.03Mpa. The drug solution should be completed within 36 hours from concentrated preparation to sterilization filtration.

[0070] Dilution and fine filtration: Install the filter (two sets of Millipore 0.22μm polyvinylidene fluoride filter elements in series) and the sterilizing filter (Millipore 0.22μm polyvinylidene fluoride filter element), which are completed in steps 1 to 5 respectively; before filtration, the integrity of the filters in the dilution and fine filtration processes and the sterilizing filter in the potting process should be checked, and the bubbling point should be ≥3450mbar (Millipore).

[0071] T1. Filter the Chinese medicine liquid in the preparation tank III to the dilution tank in the dilution room F, set the stirring frequency to 20Hz, and stir for 10 minutes. Inform the QC inspector to take samples and test the properties, pH value, and osmotic pressure molar concentration;

[0072] T2, the liquid medicine is first filtered through the dilution and fine filtration process filters (Millipore 0.22μm polyvinylidene fluoride filter element, Millipore 0.22μm polyvinylidene fluoride filter element), and then filtered through the potting process sterilization filter (Millipore 0.22μm polyvinylidene fluoride filter element) to complete four sets of filtration;

[0073] T3. Check the visible foreign matter and color of the filtered liquid, and seal it after passing the inspection. During the filtration process, the pressure difference of the pressure gauge before and after the dilution and fine filtration filters filtering the liquid shall not exceed 0.20MPa; the pressure of the filter filtering the liquid shall not exceed 0.55MPa. After the production is completed, the integrity of the dilution and fine filtration process filters and the filling process sterilization filter shall be checked. Bubble point ≥3450mbar (Millipore);

[0074] T4. During steam sterilization, the sterilization temperature is 121°C, the time is 30 minutes, the air inlet pressure should be greater than 0.1MPa, and the pressure difference between the pressure gauges before and after the cartridge filter should not exceed 0.03Mpa.

[0075] Among them, the filtration of the drug solution should be completed within 10 hours from the beginning to the end, and the filling should be completed within 12 hours.

[0076] Among them, a method for preparing a protamine sulfate injection preparation device also includes the following steps:

[0077] Step 1: Dissolve the protamine sulfate extract in water to obtain a preparation solution. At this time, the liquid inlet 82 on the preparation cylinder 81 is at the bottom center of the sterilizing filter cylinder 32 of the fixed plate 30. Pour the preparation solution into the sterilizing filter cylinder 32 with a larger pore size. Use the sterilizing filter cylinder 32 to filter and sterilize the preparation solution and enter the preparation cylinder 81, thereby completing one filtration;

[0078] Step 2: After completing the filtration of a sterilizing filter cartridge 32, the servo motor 11 rotates to drive the first screw 41 to rotate, and the lifting block 43 on the first screw 41 moves upward in the lifting frame 40. The lifting block 43 moves the flip plate 23 on the limiting base 22 upward through the lifting rod 44 and the movable groove 45. During the rising process, the flip plate 23 rotates the rotating column 27 on the flip disk 26 through the V-shaped rotating groove 21, the flip column 28 and the rotating plate 29, thereby driving the preparation cylinder 81 on the electric telescopic rod 80 to flip during the rising process. At this time, the liquid outlet 83 on the preparation cylinder 81 faces downward;

[0079] Step 3: During the rotation of the servo motor 11, the first bevel gear 42 and the second bevel gear 54 are meshed to drive the second screw 51 on the fixed block 50 to rotate synchronously. The movable block 52 on the second screw 51 realizes reciprocating motion in the limit rod 55. During the movement of the movable block 52, the fixed plate 30 is driven to move away from the flip frame 20 through the slot 56 and the movable plate 53. In the process of moving away from the flip frame 20, the second gear 60 at the bottom of the rotating shaft 34 is meshed with the rack block 73 under the support rod 72 to rotate. The second gear 60 drives the first gear 33 to rotate, and the first gear 33 engages to drive the rotating disk 31 on the annular base 35 to rotate synchronously, so that the rotating disk 31 switches to the next aperture sterilization filter cylinder 32 to the bottom of the preparation cylinder 81. At this time, the arc-shaped positioning rod 66 in the fixing frame 63 is lowered by the second stop groove 75 of the second limit plate 71, and the limit pin rod 93 in the limit seat 91 supports the limit column 65 to descend and limit, so that the second gear 60 descends and cannot engage with the rack block 73;

[0080] Step 4: Switch to the sterilizing filter cylinder 32 with another pore size to the liquid outlet 83 under the preparation cylinder 81, and extend the preparation cylinder 81 to the top of the fixed plate 30 away from the flip frame 20 through the electric telescopic rod 80, so that the liquid outlet 83 of the preparation cylinder 81 is located at the top center of the sterilizing filter cylinder 32, open the preparation cylinder 81 and pour the preparation solution after the first filtration into the sterilizing filter cylinder 32;

[0081] Step 5: The servo motor 11 reverses the movement, causing the preparation cylinder 81 to flip down and reset to the position in step 1 in the flip frame 20. At the same time, the fixed disk 30 realizes the return movement through the movable block 52 and the second screw 51. The movable cylinder 61 and the second gear 60 under the rotating shaft 34 descend without engaging with the rack block 73 during the return process. The sterilizing filter cylinder 32 containing the preparation solution on the fixed disk 30 does not rotate, but is directly driven to the top of the preparation cylinder 81. The switch under the sterilizing filter cylinder 32 is then turned on to allow the filtered preparation solution to enter the preparation cylinder 81, completing the second group of sterilizing filtration. At the same time, the arc positioning rod 66 enters the first retaining groove 74 of the first limit plate 70, causing the arc positioning rod 66 to reset and rise again, waiting for the completion of the movement and rotation of the next group of sterilizing filter cylinders 32.

[0082] Working principle: pour the prepared solution into the sterilizing filter cylinder 32 with a larger pore size, use the sterilizing filter cylinder 32 to filter and sterilize the prepared solution and enter the preparation cylinder 81, thereby completing one filtration, and the servo motor 11 rotates to drive the first screw 41 to rotate, and the lifting block 43 on the first screw 41 moves upward in the lifting frame 40, and the lifting block 43 moves the flip plate 23 on the limiting base 22 upward through the lifting rod 44 and the movable groove 45. During the rising process, the flip plate 23 rotates the rotating column 27 on the flip disk 26 through the V-shaped rotating groove 21, the flip column 28 and the rotating plate 29, so that the preparation cylinder 81 on the electric telescopic rod 80 flips during the rising process, and the liquid outlet on the preparation cylinder 81 is 83 is downward, and during the rotation of the servo motor 11, the first bevel gear 42 and the second bevel gear 54 are engaged to drive the second screw 51 on the fixed block 50 to rotate synchronously, and the movable block 52 on the second screw 51 realizes reciprocating motion in the limit rod 55. During the movement of the movable block 52, the fixed plate 30 is driven to move away from the flip frame 20 through the slot 56 and the movable plate 53. In the process of moving away from the flip frame 20, the second gear 60 at the bottom of the rotating shaft 34 is engaged with the rack block 73 under the support rod 72 for rotation, and the second gear 60 drives the first gear 33 to rotate, and the first gear 33 is engaged to drive the rotating disk 31 on the annular base 35 to rotate synchronously, so that the rotating disk 31 switches to the next aperture sterilization filter cartridge 32.

[0083] At the same time, the arc-shaped positioning rod 66 in the fixed frame 63 is lowered by the second stop groove 75 of the second limit plate 71, and the limit pin rod 93 in the limit seat 91 supports the limit column 65 to limit the downward movement, so that the second gear 60 cannot mesh with the rack block 73 when it descends. During the recovery process of the fixed disk 30, the movable cylinder 61 under the rotating shaft 34 and the second gear 60 do not mesh with the rack block 73 during the return process, and the sterilizing filter cylinder 32 containing the preparation solution on the fixed disk 30 does not rotate, and is directly driven to the top of the preparation cylinder 81;

[0084] The sterilizing filter cylinder 32 is moved to the liquid outlet 83 under the preparation cylinder 81, and the preparation cylinder 81 is extended to the top of the fixed disk 30 away from the flip frame 20 by the electric telescopic rod 80, so that the liquid outlet 83 of the preparation cylinder 81 is located at the top center of the sterilizing filter cylinder 32, and the preparation cylinder 81 is opened to pour the preparation solution after the first filtration into the sterilizing filter cylinder 32 with a smaller pore size, and then the servo motor 11 is reversed, and the fixed disk 30 realizes the return movement through the movable block 52 and the second screw 51, and the preparation cylinder 81 is restored to the bottom center of the sterilizing filter cylinder 32, and then the switch under the sterilizing filter cylinder 32 is opened to allow the preparation solution filtered again to enter the preparation cylinder 81, completing the second group of sterilizing filtration, and at the same time, the arc positioning rod 66 enters the first retaining groove 74 of the first limit plate 70, so that the arc positioning rod 66 is reset and raised again, waiting for the completion of the movement and rotation of the next group of sterilizing filter cylinders 32.

[0085] The embodiments of the present invention are described in detail above with reference to the accompanying drawings, but the present invention is not limited thereto, and various changes can be made within the knowledge scope of technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A protamine sulfate injection preparation device, comprising a preparation base (10), a flip frame (20) arranged at one end of the top of the preparation base (10), and a fixed plate (30) movable at the outer center of the top of the preparation base (10), characterized in that: The turning frame (20) is fixedly mounted at the center of one end of the top of the preparation base (10) by bolts, a V-shaped rotating groove (21) is provided at the center of one side of the inside of the turning frame (20), and a turning plate (23) is connected to the turning frame (20) on both sides of the V-shaped rotating groove (21) through a limiting base (22), a lifting frame (40) is provided at one side of the inside of the turning frame (20), and a first screw rod (41) is movably connected in the lifting frame (40), a fixing block (50) is fixedly mounted at the top of one end of the inside of the preparation base (10) by bolts, and a second screw rod (51) is movably connected between the preparation base (10) and the fixing block (50) through a bearing (90), and a rotating assembly for rotating the fixing plate (30) is provided in the preparation base (10), wherein the rotating assembly comprises: A movable block (52) movable on the second screw rod (51), movable plates (53) are fixedly installed at both ends of one side of the bottom of the fixed disk (30) by bolts, the movable block (52) is threadedly penetrated on the second screw rod (51), the center of one side of the top of the movable block (52) is fixedly installed on the bottom end of one of the movable plates (53) by bolts, a rotating disk (31) is movably arranged at the center of the top of the fixed disk (30), four groups of sterilizing filter cartridges (32) with different pore sizes are evenly installed at the center of the rotating disk (31), a first gear (33) is meshedly connected on one side of the rotating disk (31) on the fixed disk (30), a rotating shaft (34) is fixedly installed at the center of the bottom end of the first gear (33) by bolts, and the bottom of the rotating shaft (34) penetrates the bearing (90) on the fixed disk (30) and extends into the preparation base (10); a second gear (60) movable in the preparation base (10), the bottom end of the rotating shaft (34) is movably connected to a movable cylinder (61) in the preparation base (10), the bottom end of the movable cylinder (61) is fixedly installed with the second gear (60) by bolts, a fixing plate (62) is fixedly installed on one side of the rotating shaft (34) in the preparation base (10) by bolts, one side of the fixing plate (62) is movably connected to a fixing frame (63), a limiting column (65) is movably arranged in the fixing frame (63), the inside of the limiting column (65) is connected to the movable cylinder (61) through the central movable part of the bearing (90), and an arc-shaped positioning rod (66) is fixedly installed on one side of the limiting column (65) by bolts; A first limit plate (70) is fixedly installed on the preparation base (10) on the other side of the rotating shaft (34) by bolts, a second limit plate (71) is fixedly installed on the preparation base (10) on one side of the first limit plate (70) by bolts, a support rod (72) is fixedly installed on the preparation base (10) on one side between the first limit plate (70) and the second limit plate (71) by bolts, and a rack block (73) movably meshing with the second gear (60) is fixedly installed between the bottom ends of the support rod (72) by bolts.

2. A protamine sulfate injection preparation device according to claim 1, characterized in that: A T-shaped slide groove (24) is provided at the center of one side of the limiting base (22); a T-shaped slider (25) is slidably connected to the limiting base (22) in the T-shaped slide groove (24); one side of the flip plate (23) is fixedly mounted on the top of the T-shaped slider (25) by bolts; a flip plate (26) is fixedly mounted at the center of the flip plate (23) by bolts; a rotating column (27) is movably connected to the center of the rotating disk (31) by the bearing (90); a flip column (28) is movably arranged in the V-shaped rotating groove (21); and a rotating plate (29) is fixedly mounted between the rotating columns (27) by bolts; An electric telescopic rod (80) is fixedly mounted on the top of the rotating column (27) by means of bolts, a preparation barrel (81) is fixedly mounted on the top of the electric telescopic rod (80) by means of bolts, and a liquid inlet (82) and a liquid outlet (83) with a rotating cover are respectively provided at two ends of one side of the top of the preparation barrel (81), and a support groove (84) is provided on one side of the flip frame (20), and the electric telescopic rod (80) moves in the support groove (84).

3. A protamine sulfate injection preparation device according to claim 2, characterized in that: A servo motor (11) is fixedly mounted at the bottom of one end of the preparation base (10) by means of bolts, the bottom end of the first screw rod (41) passes through the flip frame (20) and extends to the output end of the servo motor (11) in the preparation base (10), and a first bevel gear (42) is fixedly mounted on the outer periphery of the bottom end of the first screw rod (41) by means of bolts, and a second bevel gear (54) meshingly connected with the first bevel gear (42) is fixedly mounted on the outer periphery of one side of the fixing block (50) by means of bolts on the second screw rod (51); In the lifting frame (40), a lifting block (43) is threadedly connected to the first screw rod (41); the center of one side of the lifting block (43) is connected to one side of the flip plate (26) through a lifting rod (44); a movable groove (45) is opened on one side of the lifting frame (40), and the lifting rod (44) is movably inserted into the movable groove (45); limiting rods (55) are fixedly installed on both sides of the second screw rod (51) on the preparation base (10) by bolts, and both ends of the movable block (52) are movably inserted into the limiting rods (55).

4. A protamine sulfate injection preparation device according to claim 3, characterized in that: An annular base (35) is fixedly mounted at the top center of the fixed disk (30) by bolts, an annular groove (36) is provided at the top center of the annular base (35), an annular block (37) is slidably connected in the annular groove (36) on the annular base (35), and the top end of the annular block (37) is fixedly mounted on the bottom of the rotating disk (31) by bolts, and the movable plate (53) on the movable block (52) movably penetrates the groove (56) provided on the preparation base (10); A fixed slide groove (12) is provided on the other side of the top of the preparation base (10), and a fixed slider (13) is slidably connected to the preparation base (10) in the fixed slide groove (12). The bottom end of the other movable plate (53) is fixedly mounted at the top center of the fixed slider (13) by bolts, and the rotating shaft (34) movably passes through a limiting groove (38) provided on the top of the preparation base (10).

5. A protamine sulfate injection preparation device according to claim 4, characterized in that: A fixing groove (67) is provided on one side of the fixing plate (62), a sliding block (68) is slidably connected to the fixing groove (67) on the fixing plate (62), one side of the fixing frame (63) is fixedly mounted on the sliding block (68) by bolts, one side of the fixing frame (63) is fixedly mounted on a limiting seat (91) by bolts, a limiting pin (93) is connected to the limiting seat (91) by a limiting spring (92), and the limiting pin (93) movably penetrates and extends into a limiting hole (94) provided on the limiting column (65).

6. The device for preparing protamine sulfate injection according to claim 5, characterized in that: An arc groove (64) is provided on one side of the top of the movable cylinder (61); an arc strip (39) whose size matches that of the arc groove (64) is fixedly installed on the outer periphery of the bottom end of the rotating shaft (34); and the arc strip (39) movably passes through the arc groove (64); a positioning groove (95) is provided on one side of the interior of the fixed frame (63); a positioning block (96) in the positioning groove (95) is connected to two ends of one side of the limiting column (65) in the fixed frame (63); and the arc positioning rod (66) movably passes through and extends to the outside of the fixed frame (63).

7. A protamine sulfate injection preparation device according to claim 6, characterized in that: A first retaining groove (74) for resisting the movement of the arc-shaped positioning rod (66) is formed on one side of the first limiting plate (70), and a second retaining groove (75) for resisting the movement of the arc-shaped positioning rod (66) is formed on one side of the second limiting plate (71), and the second retaining groove (75) is located on one side of the bottom of the first retaining groove (74), and the arc-shaped positioning rod (66) moves in the first retaining groove (74) and the second retaining groove (75).

8. The method for preparing a protamine sulfate injection preparation device according to claim 7, characterized in that: The following steps are included: Step 1: dissolving the protamine sulfate extract in water to obtain a preparation solution, wherein the liquid inlet (82) on the preparation cylinder (81) is located at the bottom center of the sterilizing filter cylinder (32) of the fixed disk (30), and the preparation solution is poured into the sterilizing filter cylinder (32) with a larger pore size, and the preparation solution is filtered and sterilized by the sterilizing filter cylinder (32) and then enters the preparation cylinder (81), thereby completing a filtering operation; Step 2: After completing the filtration of a sterilizing filter cartridge (32), the servo motor (11) rotates to drive the first screw (41) to rotate, and the lifting block (43) on the first screw (41) moves upward in the lifting frame (40). The lifting block (43) moves the flip plate (23) on the limit base (22) upward through the lifting rod (44) and the movable groove (45). During the rising process, the flip plate (23) rotates the rotating column (27) on the flip disk (26) through the V-shaped rotating groove (21), the flip column (28) and the rotating plate (29), thereby driving the preparation cylinder (81) on the electric telescopic rod (80) to flip during the rising process. At this time, the liquid outlet (83) on the preparation cylinder (81) faces downward; Step 3: During the rotation of the servo motor (11), the first bevel gear (42) and the second bevel gear (54) are meshed to drive the second screw (51) on the fixed block (50) to rotate synchronously. The movable block (52) on the second screw (51) realizes reciprocating motion in the limit rod (55). During the movement of the movable block (52), the fixed plate (30) is driven to move away from the flip frame (20) through the slot (56) and the movable plate (53). In the process of moving away from the flip frame (20), the second gear (60) at the bottom end of the rotating shaft (34) is meshed with the rack block (73) under the support rod (72) to rotate. The second gear (60) drives the first gear (33) to rotate, and the first gear (33) engages to drive the rotating disk (31) on the annular base (35) to rotate synchronously, so that the rotating disk (31) switches to the next aperture sterilization filter cylinder (32) to the bottom end of the preparation cylinder (81), and at this time, the arc-shaped positioning rod (66) in the fixed frame (63) is lowered by the second stop groove (75) of the second limit plate (71), and the limit pin rod (93) in the limit seat (91) supports the limit column (65) to descend, so that the second gear (60) descends and cannot engage with the rack block (73); Step 4: Switch to a sterilizing filter cylinder (32) with another pore size to the liquid outlet (83) under the preparation cylinder (81), extend the preparation cylinder (81) to the top of the fixed plate (30) away from the flip frame (20) through the electric telescopic rod (80), so that the liquid outlet (83) of the preparation cylinder (81) is located at the top center of the sterilizing filter cylinder (32), open the preparation cylinder (81) and pour the preparation solution after the first filtration into the sterilizing filter cylinder (32); Step 5: The servo motor (11) is reversed to make the preparation cylinder (81) turn over and descend in the turning frame (20) to reset to the position in step 1. At the same time, the fixed plate (30) realizes the return movement through the movable block (52) and the second screw (51). The movable cylinder (61) and the second gear (60) under the rotating shaft (34) descend without engaging with the rack block (73) during the return process. The sterilizing filter cylinder (32) containing the preparation solution on the fixed plate (30) does not rotate and is directly driven to the top of the preparation cylinder (81). Then, the switch under the sterilizing filter cylinder (32) is opened to allow the preparation solution filtered again to enter the preparation cylinder (81), completing the second group of sterilizing filtration. At the same time, the arc positioning rod (66) enters the first retaining groove (74) of the first limiting plate (70), so that the arc positioning rod (66) resets and rises again to wait for the completion of the movement and rotation of the next group of sterilizing filter cylinders (32).

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