Solid phase micro-extraction device for exogenous pollutants of traditional Chinese medicine

Abstract

The traditional Chinese medicine exogenous pollutant solid phase microextraction device comprises a shell with an opening in the top wall, the top wall of the shell is detachably connected with a top cover, a cavity is formed in the top cover, the top wall of the cavity is fixedly connected with a transmission motor, and an output shaft of the transmission motor is coaxially and detachably connected with a stirring rod; the stirring rod penetrates through the bottom wall of the cavity and extends into the shell, a plurality of groups of first fiber needles are fixedly connected to the side wall, located in the shell, of the stirring rod, first hole channels are formed in the side walls of the first fiber needles, extraction stationary phases are arranged on the inner side walls of the first hole channels, and the extraction stationary phases arranged on the groups of first fiber needles are different; the invention discloses a traditional Chinese medicine extraction device, which is used for solving the problem of low extraction efficiency caused by repeated extraction when various exogenous pollutants in traditional Chinese medicines are extracted by using fiber balls in the prior art to a certain extent.

Description

Technical Field

[0001] The invention belongs to the field of analysis and detection, and in particular is a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine. Background Art

[0002] The presence of pollutants in traditional Chinese medicines has brought certain hidden dangers to the safety of medication. Among them, exogenous harmful pollutants mainly include mycotoxins, pesticide residues, heavy metals, harmful elements and sulfur dioxide. Some of the above-mentioned exogenous harmful substances in traditional Chinese medicines can be extracted and detected by solid phase microextraction. In the prior art, quartz fibers coated with extraction stationary phases are often used, which are inserted into the sample matrix for stirring, so that the target extract is transferred to the extraction stationary phase. However, the quartz fibers used in this method do not make full use of the sample matrix and do not have a stirring function. Manual assisted stirring is required, and the enrichment amount of the extraction cannot be guaranteed, and the measurement accuracy cannot be guaranteed.

[0003] To solve the above problems, Chinese patent announcement No. CN107008032A discloses a sea urchin fiber ball solid phase microextraction device, which mainly includes a handle, a shell, a timer, a switch, an annular baffle, a motor, a vertical rod, a coupling, a horizontal sleeve, a horizontal rod, a latch, a fiber ball and a stirring needle. The handle is arranged on the upper part of the shell, and the shell is a cylindrical shell with an opening at the bottom. The timer is embedded in the shell, and a switch is arranged on the outer wall of the shell. The bottom of the shell is fixedly connected to the annular baffle, and a motor is arranged on the annular baffle. The motor, the timer and the switch are connected through a wire, and the output end of the motor is connected to the vertical rod through a coupling. A hollow horizontal sleeve is arranged at the bottom of the vertical rod, and a through hole is arranged on the horizontal sleeve. Horizontal rods are respectively inserted at both ends of the hollow horizontal sleeve, and through holes are arranged on the two horizontal rods. The horizontal sleeve is connected to the horizontal rod by a latch, one end of the two horizontal rods is inserted in the horizontal sleeve, and the other end is respectively fixedly connected to a fiber ball, and a number of stirring needles are fixedly connected to the outer wall of each fiber ball.

[0004] The above-mentioned device solves the problems existing in the prior art that manual stirring is required, the enrichment amount of the extraction cannot be guaranteed, and the measurement accuracy cannot be guaranteed. However, the device uses fiber balls, and multiple extractions are required when extracting various exogenous pollutants in traditional Chinese medicine, resulting in low extraction efficiency. Therefore, it is necessary to propose a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine, which can solve the problems existing in the prior art that fiber balls are used, and multiple extractions are required when extracting various exogenous pollutants in traditional Chinese medicine, resulting in low extraction efficiency. Summary of the invention

[0005] The purpose of the present invention is to provide a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine, which is used to solve the problem in the prior art that fiber balls are used to extract multiple exogenous pollutants in traditional Chinese medicine, requiring multiple extractions, resulting in low extraction efficiency.

[0006] In order to achieve the above-mentioned purpose, the technical scheme of the present invention is as follows: a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine, comprising a shell with an opening on the top wall, a top cover detachably connected to the top wall of the shell, a chamber opened in the top cover, a transmission motor fixedly connected to the top wall of the chamber, a stirring rod coaxially and detachably connected to the output shaft of the transmission motor, the stirring rod passes through the bottom wall of the chamber and extends into the shell, the stirring rod is located on the side wall inside the shell and is fixedly connected to a plurality of groups of first fiber needles, the side walls of the first fiber needles are all provided with first channels, the inner side walls of the first channels are all provided with extraction stationary phases, and the extraction stationary phases arranged on each group of first fiber needles are different.

[0007] After adopting the above scheme, the following principles and beneficial effects are realized: when using this device, the Chinese medicine extraction raw material to be extracted is placed in the outer shell, and the stirring rod is driven to rotate by the transmission motor, so that the first fiber needle stirs in the extraction raw material, and the different extraction fixed phases carried by different groups of first fiber needles are used to extract different exogenous pollutant residues in the extraction raw material, thereby effectively shortening the time required for extracting exogenous pollutants from Chinese medicine, effectively improving the extraction efficiency, and to a certain extent solving the problem in the prior art that when using fiber balls to extract multiple exogenous pollutants in Chinese medicine, multiple extractions are required, resulting in low extraction efficiency.

[0008] Furthermore, a plurality of markers are provided in the shell, a first coil is fixedly connected to the bottom wall of the shell, a plurality of second coils are fixedly connected to the inner wall of the shell, a controller is fixedly connected in the chamber, and the second coils are used to collect position information of the markers, and the controller controls the operation of the transmission motor according to the position information.

[0009] Beneficial effect: When using this device, the first coil is energized, and the first coil generates an electromagnetic effect to charge the marker. In the process of the extraction needle stirring the extraction raw material, the extraction needle drives the marker to move with the extraction raw material. During the movement, the controller controls the operation of the transmission motor through the position information of the marker collected by the second coil. When the position of the marker does not move or accumulation occurs, the stirring is uneven. The controller controls the transmission motor to increase the power until all the marks of the marker are not stationary and are distributed more evenly, thereby avoiding the problem of poor subsequent measurement accuracy due to uneven stirring to a certain extent.

[0010] Furthermore, a temperature sensor is fixedly connected to the inner wall of the shell, and the temperature sensor is used to collect temperature information of the extracted raw material in the shell. The temperature sensor and the first coil are both electrically connected to the controller.

[0011] Beneficial effect: When using this device, after the first coil is energized, the first coil drives the marker to heat the extraction raw material. The controller controls the operation of the first coil through the extraction raw material temperature information transmitted back by the temperature sensor. When the temperature information exceeds the set value, the controller controls the first coil to stop working, thereby increasing the extraction raw material temperature, accelerating the diffusion rate of molecules in the extraction raw material, shortening the extraction time, and to a certain extent avoiding excessive reduction in the equilibrium distribution coefficient and the adsorption amount of the extraction fixed relative to the extraction raw material, which affects the extraction process.

[0012] Furthermore, the stirring rod is located on the side wall of the shell and is fixedly connected to a plurality of auxiliary stirring rods.

[0013] Beneficial effect: When using the device, the auxiliary stirring rod can speed up the stirring rate, accelerate the mixing of the extraction raw materials, and thus shorten the extraction time.

[0014] Furthermore, several groups of second fiber needles are fixedly connected to the auxiliary stirring rods, second channels are opened on the side walls of the second fiber needles, extraction stationary phases are arranged on the inner side walls of the second channels, and the extraction stationary phases arranged on each group of second fiber needles are different.

[0015] Beneficial effects: When using the device, the setting of the second fiber needle can increase the contact area between the extraction stationary phase and the exogenous pollutants in the extraction raw material, thereby improving the extraction efficiency and further shortening the extraction time.

[0016] Furthermore, a guide plate is fixedly connected to the outer wall of the shell, and the inner wall of the guide plate is slidably connected to the side wall of the top cover.

[0017] Beneficial effect: During the use of the device, the setting of the guide plate can prevent the first fiber needle and the second fiber needle from colliding with the inner wall of the outer shell when the operator moves the top cover, causing the first fiber needle and the second fiber needle to break, affecting the subsequent measurement accuracy and causing contamination to the extracted raw materials after the extraction is completed.

[0018] Furthermore, a sound-absorbing pad made of rubber is fixedly connected to the inner wall of the chamber.

[0019] Beneficial effect: During the use of the device, the sound-absorbing pad can absorb part of the vibration generated by the transmission motor, thereby reducing the noise generated by the vibration of the transmission motor and improving the user experience of the device.

[0020] Furthermore, a rubber pad is fixedly connected to the outer bottom wall of the shell.

[0021] Beneficial effect: When using the device, place it on an operating plane. The rubber pad increases the friction between the shell and the operating plane, thereby reducing the vibration generated by the driving motor during use, which may cause the shell to fall over and affect the extraction process. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a cross-sectional view of an embodiment of a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to the present invention;

[0023] Figure 2 The present invention is a schematic circuit diagram of a solid phase microextraction device for exogenous pollutants in traditional Chinese medicine. DETAILED DESCRIPTION

[0024] The following is further described in detail through specific implementation methods:

[0025] The figure marks in the drawings of the specification include: shell 1, rubber pad 11, first coil 12, second coil 13, stirring rod 2, first fiber needle 21, auxiliary stirring rod 3, second fiber needle 31, top cover 4, sound absorbing pad 41, transmission motor 5, guide plate 6.

[0026] Embodiment 1

[0027] The embodiment is basically as shown in the attached Figure 1-2 As shown:

[0028] A solid phase microextraction device for exogenous pollutants in traditional Chinese medicine comprises a shell 1 with an opening on the top wall, the top wall of the shell 1 is detachably connected to a top cover 4 by a buckle, a chamber is opened in the top cover 4, the top wall of the chamber is fixedly connected to a transmission motor 5 by bolts, the model of the transmission motor 5 is preferably CC-M3H040-NN14, the output shaft of the transmission motor 5 is coaxially detachably connected to a stirring rod 2 by a buckle, the stirring rod 2 passes through the bottom wall of the chamber and extends into the shell 1, a plurality of groups of first fiber needles 21 are bonded to the side wall of the stirring rod 2 located in the shell 1, the side walls of the first fiber needles 21 are all provided with first channels, the inner side walls of the first channels are all provided with extraction stationary phases, and the extraction stationary phases arranged on each group of first fiber needles 21 are all different.

[0029] The specific implementation process is as follows: when using the device, the Chinese medicine extraction raw material to be extracted is placed in the outer shell 1, the top cover 4 is covered, the opening is closed, and the transmission motor 5 is started. The transmission motor 5 drives the first fiber needle 21 to stir in the extraction raw material through the stirring rod 2. The different extraction fixed phases carried by the first fiber needles 21 of different groups are used to extract the pesticide residues, plant growth regulator residues, sulfur dioxide residues and other exogenous pollutant residues in the extraction raw material, thereby effectively shortening the time required for extracting exogenous pollutants in Chinese medicine and effectively improving the extraction efficiency.

[0030] Embodiment 2

[0031] The difference from the above embodiment is that: a plurality of markers are arranged in the shell 1, the material of the markers is preferably nickel, and the markers have the same shape as the extraction raw material, the bottom wall of the shell 1 is fixedly connected to the first coil 12 by bolts, the inner wall of the shell 1 is fixedly connected to the plurality of second coils 13 by bolts, a controller is fixedly connected in the chamber by bolts, the model of the controller is preferably 2080Micro850, and the second coils 13 and the transmission motor 5 are electrically connected to the controller.

[0032] The specific implementation process is as follows: when using this device, the first coil 12 is energized, and the first coil 12 generates an electromagnetic effect to make the marker charged. In the process of the extraction needle stirring the extraction raw material, the extraction needle drives the marker to move with the extraction raw material. During the movement, the second coil 13 collects the position information of the marker. When the position of the marker does not move or accumulates, the device does not stir the extraction raw material sufficiently at this time. The controller controls the transmission motor 5 to continuously increase the power, thereby increasing the stirring rate of the first fiber needle 21 on the extraction raw material, until all the marks of the marker are not stationary and are relatively evenly distributed, thereby avoiding the problem of poor subsequent measurement accuracy due to uneven stirring to a certain extent.

[0033] Embodiment 3

[0034] The difference from the above embodiment is that a temperature sensor is fixedly connected to the inner wall of the shell 1 by bolts. The model of the temperature sensor is preferably 718-272969-001. The temperature sensor is used to collect temperature information of the extracted raw materials in the shell 1. The temperature sensor and the first coil 12 are both electrically connected to the controller.

[0035] The specific implementation process is as follows: when using the device, after the first coil 12 is energized, the first coil 12 drives the marker to produce an eddy current effect, thereby generating a thermal effect to heat the extraction raw material. At the same time, the temperature sensor continues to collect temperature information of the extraction raw material. When the temperature information exceeds the set value, the controller controls the first coil 12 to stop working, thereby increasing the temperature of the extraction raw material, accelerating the diffusion rate of molecules in the extraction raw material, shortening the extraction time, and to a certain extent avoiding excessive reduction in the equilibrium distribution coefficient and the adsorption amount of the extraction fixed relative to the extraction raw material, which affects the extraction process.

[0036] Embodiment 4

[0037] The difference from the above embodiment is that a plurality of auxiliary stirring rods 3 are welded and fixed on the side wall of the stirring rod 2 located inside the housing 1 .

[0038] The specific implementation process is as follows: when using the device, the auxiliary stirring rod 3 can increase the contact area between the stirring rod 2 and the extraction raw material, thereby accelerating the stirring rate, accelerating the mixing of the extraction raw material, and thus shortening the extraction time.

[0039] Embodiment 5

[0040] The difference from the above embodiment is that: a plurality of groups of second fiber needles 31 are bonded and fixed to the auxiliary stirring rod 3, a second channel is opened on the side wall of the second fiber needle 31, an extraction stationary phase is arranged on the inner wall of the second channel, and the extraction stationary phase arranged on each group of second fiber needles 31 is different.

[0041] The specific implementation process is as follows: when using the device, the setting of the second fiber needle 31 can increase the contact area between the extraction stationary phase and the exogenous pollutants in the extraction raw material by increasing the amount of the extraction stationary phase during the stirring process, thereby improving the extraction efficiency and further shortening the extraction time.

[0042] Embodiment 6

[0043] The difference from the above embodiment is that a guide plate 6 is welded and fixed on the outer wall of the housing 1, and the inner wall of the guide plate 6 is slidably connected to the side wall of the top cover 4 via a slide rail.

[0044] The specific implementation process is as follows: after using the device, the top cover 4 is moved upward, and the top cover 4 drives the stirring rod 2 and the like to leave the outer shell 1. The setting of the guide plate 6 can prevent the first fiber needle 21 and the second fiber needle 31 from colliding with the inner wall of the outer shell 1 when the operator moves the top cover 4, causing the first fiber needle 21 and the second fiber needle 31 to break, affecting the subsequent measurement accuracy and causing pollution to the extracted raw materials after the extraction is completed.

[0045] Embodiment 7

[0046] The difference from the above embodiment is that a sound-absorbing pad 41 made of rubber is bonded and fixed to the inner wall of the chamber.

[0047] The specific implementation process is as follows: when using the device, the sound-absorbing pad 41 can convert the mechanical energy of the vibration generated by the transmission motor 5 into its own heat energy, thereby reducing the noise generated by the vibration of the transmission motor 5 and improving the user experience of the device.

[0048] Embodiment 8

[0049] The difference from the above embodiment is that a rubber pad 11 is bonded and fixed to the outer bottom wall of the housing 1 .

[0050] The specific implementation process is as follows: when using the device, place the device on an operating plane. The rubber pad 11 increases the contact area between the outer wall of the shell 1 and the operating plane through elastic deformation, thereby increasing the friction between the shell 1 and the operating plane, and reducing the vibration generated by the transmission motor 5 during use, which causes the shell 1 to fall over and affects the extraction process.

[0051] The above is only an embodiment of the present invention. The common sense such as the known specific structure and characteristics in the scheme is not described in detail here. The ordinary technicians in the relevant field know all the common technical knowledge in the technical field of the invention before the application date or priority date, can obtain all the existing technologies in the field, and have the ability to apply the conventional experimental means before that date. The ordinary technicians in the relevant field can improve and implement this scheme in combination with their own abilities under the enlightenment given by this application. Some typical known structures or known methods should not become obstacles for ordinary technicians in the relevant field to implement this application. It should be pointed out that for those skilled in the art, without departing from the structure of the present invention, several deformations and improvements can be made, which should also be regarded as the protection scope of the present invention, which will not affect the effect of the implementation of the present invention and the practicality of the patent. The protection scope required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A solid phase microextraction device for exogenous pollutants in traditional Chinese medicine, characterized in that: The invention comprises an outer shell with an opening on the top wall, a top cover detachably connected to the top wall of the outer shell, a chamber formed in the top cover, a transmission motor fixedly connected to the top wall of the chamber, a stirring rod coaxially and detachably connected to the output shaft of the transmission motor, the stirring rod penetrates the bottom wall of the chamber and extends into the outer shell, the stirring rod is located on the side wall inside the outer shell and is fixedly connected to a plurality of groups of first fiber needles, first channels are formed on the side walls of the first fiber needles, extraction stationary phases are formed on the inner side walls of the first channels, and the extraction stationary phases formed on the respective groups of first fiber needles are different.

2. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 1, characterized in that: A plurality of markers are arranged in the shell, a first coil is fixedly connected to the bottom wall of the shell, a plurality of second coils are fixedly connected to the inner wall of the shell, a controller is fixedly connected in the chamber, and the second coils are used to collect the position information of the markers. The controller controls the operation of the transmission motor according to the position information.

3. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 2, characterized in that: A temperature sensor is fixedly connected to the inner wall of the shell, and the temperature sensor is used to collect temperature information of the extracted raw material in the shell. The temperature sensor and the first coil are both electrically connected to the controller.

4. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 3, characterized in that: The stirring rod is located on the side wall inside the shell and is fixedly connected with a plurality of auxiliary stirring rods.

5. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 4, characterized in that: Several groups of second fiber needles are fixedly connected to the auxiliary stirring rods, the side walls of the second fiber needles are each provided with a second channel, the inner side walls of the second channel are each provided with an extraction stationary phase, and the extraction stationary phases provided on each group of second fiber needles are different.

6. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 5, characterized in that: A guide plate is fixedly connected to the outer side wall of the shell, and the inner side wall of the guide plate is slidably connected to the side wall of the top cover.

7. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 6, characterized in that: A sound-absorbing pad made of rubber is fixedly connected to the inner side wall of the chamber.

8. The solid phase microextraction device for exogenous pollutants in traditional Chinese medicine according to claim 7, characterized in that: The outer bottom wall of the shell is fixedly connected with a rubber pad.

Images