Intelligent venous catheter system for conducting diaphragm electrical stimulation through veins

Abstract

The invention discloses an intelligent venous catheter system for conducting diaphragm electrical stimulation through veins, and the system comprises an intelligent venous catheter which is integrated with at least one electrode array; the electrode array is distributed in the length direction of the intelligent venous catheter in a spiral arrangement mode and comprises at least 30 independent and independently controllable micro stimulating electrodes. A guide wire channel for guiding the electrode array and signal transmission, an insulating layer and a sealing structure are arranged in the intelligent venous catheter; the intelligent controller is used for sending a control electrical stimulation signal to the electrode array on the intelligent venous catheter; the electrical stimulation signal comprises stimulation parameters which can be freely adjusted; one end of the airway sensor is connected with the airway of the patient, the other end of the airway sensor is connected with the intelligent controller, and the airway sensor is used for monitoring the breathing state, the breathing frequency, the breathing depth and the airway pressure of the patient in real time. According to the invention, fine control, parameter adjustment and monitoring are carried out on a plurality of independent stimulation electrodes which can be independently controlled, so that diaphragm muscles can be more effectively activated and exercised.

Description

Technical Field

[0001] The present invention relates to the field of auxiliary medical technology, and in particular to an intelligent intravenous catheter system and computing equipment for performing diaphragm electrical stimulation via vein. Background Art

[0002] Diaphragm dysfunction is a common disease. To improve diaphragm function, existing diaphragm electrical stimulation methods usually use surface electrodes or implantable electrodes. Among them, although the surface electrode method is easy to operate, the stimulation effect is often not accurate enough because the position and shape of the electrode are difficult to fully match the target phrenic nerve area. In addition, the surface electrode is easily affected by factors such as skin impedance and the contact quality between the electrode and the skin, and the stimulation effect is unstable. Although the implantable electrode method can achieve more accurate stimulation, the implantation operation itself has certain risks, and the implanted electrode is easily affected by the internal environment (such as tissue wrapping, electrode corrosion, etc.), thereby affecting the stimulation effect, and the implantable electrode also needs to be maintained and replaced regularly, which brings additional burden to the patient. In addition, the existing diaphragm electrical stimulation system usually lacks real-time physiological parameter monitoring and feedback mechanism. Doctors often rely on experience or fixed treatment plans when setting stimulation parameters, and cannot dynamically adjust according to the patient's real-time physiological state, resulting in poor treatment effect and even unnecessary complications. For example, improper setting of stimulation parameters such as current and voltage may cause damage to the patient, and abnormal physiological parameters such as airway pressure may also endanger the patient's life safety.

[0003] To solve the above problems, the present invention proposes an intelligent intravenous catheter system for diaphragm electrical stimulation via vein, so as to more effectively activate and exercise the diaphragm muscle. Summary of the invention

[0004] In view of the above problems, the present invention provides an intelligent intravenous catheter system and a computing device for performing diaphragm electrical stimulation via vein.

[0005] According to one aspect of the present invention, there is provided an intelligent intravenous catheter system for performing diaphragmatic electrical stimulation via a vein, comprising:

[0006] An intelligent intravenous catheter, integrating at least one electrode array; the electrode array is distributed in a spiral arrangement along the length of the intelligent intravenous catheter, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrodes electrically stimulate the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guidewire channel, an insulating layer, and a sealing structure for guiding the electrode array and signal transmission;

[0007] An intelligent controller connected to the intelligent venous catheter, and used to send a control electrical stimulation signal to the electrode array on the intelligent venous catheter; the electrical stimulation signal includes freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform;

[0008] The airway sensor has one end connected to the patient's airway and the other end connected to the intelligent controller, and is used to monitor the patient's breathing state, breathing frequency, breathing depth and airway pressure in real time.

[0009] In an optional manner, the electrode array is connected to a high-efficiency conductive path through an insulating material to form a closed-loop circuit structure, and the closed-loop circuit structure is used to automatically adjust stimulation parameters according to real-time feedback from an airway sensor.

[0010] In an optional manner, the closed-loop circuit structure includes:

[0011] A signal generator, connected to the signal amplifier via an SPI / I2 C interface, for generating an electrical stimulation signal, wherein the electrical stimulation signal includes a set current intensity, a pulse width, a stimulation frequency, a stimulation mode, and a stimulation waveform;

[0012] A signal amplifier, connected to the multiplexer via an analog signal line, transmits the amplified signal to the multiplexer to generate a weak signal to drive the electrode array to perform electrical stimulation;

[0013] A multiplexer connected to the isolation circuit via an analog signal line, and the isolation circuit is connected to the electrode array via an isolation signal line; used to selectively transmit the amplified signal to each electrode to independently control the multiple electrodes;

[0014] An isolation circuit, connected to the electrode array via an isolation signal line, transmits the isolated signal to the electrode array; and is used to provide electrical isolation to prevent current from flowing directly through the patient's body;

[0015] An electrode array for converting received electrical stimulation signals into electric currents to act on the target phrenic nerve area to activate and exercise the diaphragm muscle;

[0016] A feedback circuit is connected to the airway sensor via an analog signal line, and is used to receive the respiratory state, respiratory frequency, respiratory depth, and airway pressure monitored in real time by the airway sensor and convert them into electrical signals;

[0017] The microcontroller is connected to the signal generator via an SPI / I2 C interface, and is used to receive information from the feedback circuit and send instructions to the signal generator according to a preset control algorithm to adjust the parameters of the electrical stimulation signal.

[0018] In an optional manner, after the signal generator generates the electrical stimulation signal, the method further comprises:

[0019] The electrical stimulation signal generated by the signal generator is adjusted, wherein the adjustment formula of the electrical stimulation signal is:

[0020]

[0021] Among them, U(t) is the adjusted electrical stimulation parameter P t Output control quantity; K p is the proportional gain; K i is the integral gain; K d is the differential gain; e(t) is the error signal, that is, the deviation between the actual measured value and the expected value; t is the time.

[0022] In an optional manner, the multiplexer selects electrodes for stimulation using a polling method, comprising the following steps:

[0023] Initialize electrode selection sequence;

[0024] Cycle through the electrode selection sequence, selecting each electrode for stimulation in turn;

[0025] Switch to the next electrode according to the preset stimulation time and interval.

[0026] In an optional manner, the feedback circuit further includes an analog-to-digital converter, and the interpolation calculation formula for improving the signal resolution of the analog-to-digital converter is:

[0027]

[0028] Among them, Interpolated value is the signal value after interpolation; value1 and value2 are the signal values ​​of two known adjacent sampling points; ADC Code is the current ADC code value; Code1 and Code2 are the ADC code values ​​corresponding to value1 and value2.

[0029] In an optional manner, the intelligent controller further includes a user interface;

[0030] The user interface is used to receive input or adjust parameters of the electrical stimulation signal;

[0031] Furthermore, the user interface is used to display in real time the respiratory state, respiratory rate, respiratory depth and airway pressure monitored by the airway sensor, so as to adjust or set new stimulation parameters through real-time display information.

[0032] In an optional manner, the system further includes a safety monitoring module;

[0033] The safety monitoring module is connected to the intelligent controller, the electrode array and the airway sensor;

[0034] The safety monitoring module is used to monitor the current, voltage and airway pressure during the electrical stimulation process in real time. When one of the current, voltage and airway pressure exceeds a preset safety value, the electrical stimulation signal is automatically cut off or adjusted immediately.

[0035] In an optional manner, the material of the guide wire channel is polytetrafluoroethylene or polyurethane;

[0036] The insulating layer is made of polyvinyl chloride and covers the outside of the electrode array and the guide wire channel;

[0037] The sealing structure is made of thermoplastic elastomer and is arranged at the end or connection of the intelligent intravenous catheter.

[0038] According to another aspect of the present invention, there is provided a computing device, comprising: a processor, a memory, a communication interface and a communication bus, wherein the processor, the memory and the communication interface communicate with each other via the communication bus;

[0039] The memory is used to store at least one executable instruction, and the executable instruction enables the processor to execute operations corresponding to the above-mentioned intelligent intravenous catheter system for diaphragm electrical stimulation through the vein.

[0040] According to the scheme provided by the present invention, it includes an intelligent intravenous catheter, which integrates at least one electrode array; the electrode array is distributed along the length direction of the intelligent intravenous catheter in a spiral arrangement, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrode electrically stimulates the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guide wire channel, an insulating layer and a sealing structure for guiding the electrode array and signal transmission; an intelligent controller is connected to the intelligent intravenous catheter, and is used to send a control electrical stimulation signal to the electrode array on the intelligent intravenous catheter; the electrical stimulation signal includes freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform; an airway sensor, one end of which is connected to the patient's airway, and the other end is connected to the intelligent controller, which is used to monitor the patient's respiratory state, respiratory frequency, respiratory depth and airway pressure in real time. The present invention sets a spirally arranged electrode array on the intelligent intravenous catheter, which can accurately stimulate the target phrenic nerve area, and can more effectively activate and exercise the diaphragm muscle through multiple independent and independently controllable micro-stimulation electrodes. The intelligent controller sends electrical stimulation signals containing freely adjustable stimulation parameters, which improves the effectiveness of treatment. The airway sensor monitors the patient's breathing status, respiratory rate, respiratory depth, and airway pressure physiological parameters in real time, so that the feedback process of electrical stimulation can be grasped in time.

[0041] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, it can be implemented according to the contents of the specification. In order to make the above and other purposes, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Moreover, the same reference symbols are used throughout the accompanying drawings to represent the same components. In the accompanying drawings:

[0043] Figure 1 A schematic diagram showing a framework of an intelligent intravenous catheter system for performing diaphragm electrical stimulation via a vein according to an embodiment of the present invention;

[0044] Figure 2 A schematic diagram of the circuit structure of an embodiment of the present invention is shown;

[0045] Figure 3 to Figure 4 A schematic diagram showing the stimulation electrode according to an embodiment of the present invention acting on the target phrenic nerve area;

[0046] Figure 5 A schematic diagram of a ventilator according to an embodiment of the present invention is shown;

[0047] Figure 6 A schematic diagram showing an intelligent intravenous catheter system for performing diaphragm electrical stimulation via a vein according to an embodiment of the present invention is shown;

[0048] Figure 7 A schematic diagram of the structure of a computing device according to an embodiment of the present invention is shown. DETAILED DESCRIPTION

[0049] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present invention and to enable the scope of the present invention to be fully communicated to those skilled in the art.

[0050] Figure 1 FIG. 1 is a schematic diagram showing a framework of an intelligent intravenous catheter system for performing diaphragm electrical stimulation via a vein according to an embodiment of the present invention. Specifically, Figure 1 As shown, including:

[0051] An intelligent intravenous catheter integrates at least one electrode array; the electrode array is distributed in a spiral arrangement along the length of the intelligent intravenous catheter, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrodes electrically stimulate the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guidewire channel, an insulating layer, and a sealing structure for guiding the electrode array and signal transmission.

[0052] In this embodiment, the electrode array provided on the catheter is arranged in a spiral shape, and includes at least 30 independent and independently controllable micro-stimulation electrodes, which can achieve precise electrical stimulation of the target phrenic nerve area, thereby avoiding stimulation of non-target areas. The interior of the catheter includes a guidewire channel, an insulating layer, and a sealing structure to ensure the reliability of the electrode array and signal transmission. The electrode array is distributed along the length of the catheter in a spiral arrangement to cover the target phrenic nerve area. A guidewire channel is set inside the catheter to guide the electrode array and signal transmission.

[0053] An intelligent controller is connected to the intelligent venous catheter and is used to send a control electrical stimulation signal to the electrode array on the intelligent venous catheter; the electrical stimulation signal contains freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform.

[0054] In this embodiment, the intelligent controller sends out current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform, which include freely adjustable stimulation parameters. Doctors or therapists can precisely control the electrode array on the intelligent venous catheter to ensure that the electrical stimulation signal accurately acts on the target area and reduce potential impact on non-target areas.

[0055] The airway sensor is connected to the patient's airway at one end and to the intelligent controller at the other end, and is used to monitor the patient's respiratory status, respiratory rate, respiratory depth and airway pressure in real time, and display the results in real time on the display screen. When the patient's respiratory status, respiratory rate, respiratory depth and airway pressure exceed the preset alarm threshold, the intelligent controller will issue an alarm sound or light prompt to remind the doctor to take timely measures.

[0056] When using, Figures 3 to 6 As shown in the figure, under local anesthesia, the doctor inserts the smart intravenous catheter into the patient's blood vessels and guides it to the vicinity of the target phrenic nerve area. Through computer control software, the doctor sets the stimulation intensity, frequency, and duration, etc. After the electrical stimulation function is activated, the micro-stimulation electrodes begin to release electrical signals to activate and exercise the diaphragm muscles. During the treatment, the doctor closely monitors the patient's vital signs and reactions, such as respiratory rate, heart rate, etc. According to the treatment effect and the patient's tolerance, the doctor can adjust the stimulation parameters in time.

[0057] In an optional manner, the electrode array is connected to a high-efficiency conductive path through an insulating material to form a closed-loop circuit structure, and the closed-loop circuit structure is used to automatically adjust stimulation parameters according to real-time feedback from an airway sensor.

[0058] In this embodiment, the closed-loop circuit structure automatically adjusts the stimulation parameters of the electrode array according to the feedback data to ensure that the electrical stimulation therapy always matches the actual breathing condition of the patient. The efficient conductive path ensures that the electrical stimulation signal can be transmitted to the electrode array quickly and stably. The closed-loop circuit structure can ensure that the electrical stimulation therapy is always in the best state through the automatic adjustment function, thereby improving the treatment efficiency. By adjusting the stimulation parameters in real time, the closed-loop circuit structure can avoid over-stimulation or under-stimulation, thereby enhancing the patient's comfort and reducing the burden on the patient.

[0059] In an optional manner, the closed-loop circuit structure includes:

[0060] A signal generator, connected to the signal amplifier via an SPI / I2 C interface, for generating an electrical stimulation signal, wherein the electrical stimulation signal includes a set current intensity, a pulse width, a stimulation frequency, a stimulation mode, and a stimulation waveform;

[0061] A signal amplifier, connected to the multiplexer via an analog signal line, transmits the amplified signal to the multiplexer to generate a weak signal to drive the electrode array to perform electrical stimulation;

[0062] A multiplexer connected to the isolation circuit via an analog signal line, and the isolation circuit is connected to the electrode array via an isolation signal line; used to selectively transmit the amplified signal to each electrode to independently control the multiple electrodes;

[0063] An isolation circuit, connected to the electrode array via an isolation signal line, transmits the isolated signal to the electrode array; and is used to provide electrical isolation to prevent current from flowing directly through the patient's body;

[0064] An electrode array for converting received electrical stimulation signals into electric currents to act on the target phrenic nerve area to activate and exercise the diaphragm muscle;

[0065] A feedback circuit is connected to the airway sensor via an analog signal line, and is used to receive the respiratory state, respiratory frequency, respiratory depth, and airway pressure monitored in real time by the airway sensor and convert them into electrical signals;

[0066] The microcontroller is connected to the signal generator via an SPI / I2 C interface, and is used to receive information from the feedback circuit and send instructions to the signal generator according to a preset control algorithm to adjust the parameters of the electrical stimulation signal.

[0067] In this embodiment, Figure 2As shown, the signal generator is connected to the signal amplifier through the SPI / I2 C interface circuit to generate an electrical stimulation signal containing parameters such as set current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform. The signal amplifier receives the signal from the signal generator through the analog signal input port, and is connected to the multiplexer through the analog signal output port to amplify the weak signal generated by the signal generator to a level sufficient to drive the electrode array for electrical stimulation. The multiplexer receives the signal from the signal amplifier through the analog signal input port, and is connected to the isolation circuit through the analog signal output port, and can selectively transmit the amplified signal to each electrode so as to independently control multiple electrodes. The isolation circuit receives the signal from the multiplexer through the analog signal input port, and is connected to the electrode array through the isolation signal output port, providing electrical isolation function to prevent current from flowing directly through the patient's body, thereby ensuring the safety of the treatment process. The electrode array is connected to the isolation signal output port of the isolation circuit through the electrode, converts the received electrical stimulation signal into current, and acts on the target phrenic nerve area to activate and exercise the diaphragm muscle. The feedback circuit is connected to the airway sensor through the analog signal input port, and is connected to the microcontroller through the analog signal output port (or directly connected to the analog signal input port of the microcontroller), and converts the received real-time monitored respiratory status information (respiratory rate, respiratory depth, airway pressure, etc.) into electrical signals for processing by the microcontroller. The microcontroller is connected to the signal generator through the SPI / I2 C interface circuit and receives the signal of the feedback circuit through the analog signal input port. As the control center of the system, the microcontroller receives information from the feedback circuit and sends instructions to the signal generator according to the preset control algorithm to adjust the parameters of the electrical stimulation signal. The isolation circuit ensures that the current does not flow directly through the patient's body, and the multiplexer independently controls multiple electrodes to treat specific nerve areas.

[0068] In an optional manner, after the signal generator generates the electrical stimulation signal, the method further comprises:

[0069] The electrical stimulation signal generated by the signal generator is adjusted, wherein the adjustment formula of the electrical stimulation signal is:

[0070]

[0071] Among them, U(t) is the adjusted electrical stimulation parameter P t Output control quantity; K p is the proportional gain; K i is the integral gain; K d is the differential gain; e(t) is the error signal, that is, the deviation between the actual measured value and the expected value; t is the time.

[0072] In this embodiment, by introducing proportional, integral, and differential control, the electrical stimulation signal can be adjusted more accurately to better match the expected value and adapt to the needs of different individuals or under different conditions. In addition, it can quickly reach a stable state, reduce fluctuations and overshoots, and ensure the stable output of the electrical stimulation signal.

[0073] Specifically, the initial electrical stimulation signal is generated by a signal generator, including the frequency, amplitude, waveform and other parameters of the signal. The electrical stimulation parameters are compared with the expected values ​​to obtain an error signal, and the adjusted electrical stimulation parameter output control amount is calculated and added as the new electrical stimulation parameter output control amount to adjust the output of the signal generator to match the expected value until a stable state is reached or the error is within an acceptable range.

[0074] In an optional manner, the multiplexer selects electrodes for stimulation using a polling method, comprising the following steps:

[0075] Initialize electrode selection sequence;

[0076] Cycle through the electrode selection sequence, selecting each electrode for stimulation in turn;

[0077] Switch to the next electrode according to the preset stimulation time and interval.

[0078] In this embodiment, the multiplexer uses a polling method to perform stimulation, which can ensure that each electrode can be stimulated evenly and orderly, and avoid overheating or damage caused by long-term continuous stimulation of a certain electrode.

[0079] Specifically, the stimulation electrodes are arranged in a certain order to form an electrode selection sequence, and the electrode selection sequence is input into the multiplexer for initialization setting. After the multiplexer starts working, each electrode is selected for stimulation in turn according to a preset order. When selecting each electrode, the multiplexer connects it to a power supply and outputs a corresponding stimulation signal. According to the preset stimulation time and interval, switch to the next electrode. When stimulating each electrode, the multiplexer controls the duration of the stimulation signal according to the preset stimulation time. After the stimulation is completed, the multiplexer waits for a period of time according to the preset interval time, and then switches to the next electrode for stimulation, and repeats until all electrodes are stimulated.

[0080] For example, determine the positions and numbers (E1, E2, ..., E30) of the 30 electrodes that need to be stimulated, and arrange them in order into an electrode selection sequence: E1, E2, ..., E30. Input the electrode selection sequence into the multiplexer, and after the multiplexer starts working, select electrode E1 for stimulation. After the stimulation is completed, the multiplexer waits for a period of time (such as 1 second), and then switches to electrode E2 for stimulation until electrode E30 is stimulated once. Switch to the next electrode according to the preset stimulation time and interval. Assume that the preset stimulation time is 2 seconds and the interval time is 1 second. When stimulating electrode E1, the multiplexer outputs a 2-second stimulation signal. After the stimulation is completed, the multiplexer waits for 1 second, and then switches to electrode E2 for stimulation, and so on until all electrodes are stimulated once.

[0081] In an optional manner, the feedback circuit further includes an analog-to-digital converter, and the interpolation calculation formula for improving the signal resolution of the analog-to-digital converter is:

[0082]

[0083] Among them, Interpolated value is the signal value after interpolation; value1 and value2 are the signal values ​​of two known adjacent sampling points; ADC Code is the current ADC code value; Code1 and Code2 are the ADC code values ​​corresponding to value1 and value2.

[0084] In this embodiment, the resolution of the signal can be improved by interpolation calculation without increasing the resolution of the ADC hardware. Specifically, the analog signal is sampled by the ADC to obtain a series of discrete ADC code values, which represent the quantized values ​​of the signal at different time points. Two adjacent sampling points are selected and their ADC code values ​​(Code1 and Code2) and corresponding signal values ​​(value1 and value2) are obtained. For the current ADC code value ADC Code Use the interpolation formula to calculate the interpolated signal value Interpolated value .

[0085] In an optional manner, the intelligent controller further includes a user interface;

[0086] The user interface is used to receive input or adjust parameters of the electrical stimulation signal;

[0087] Furthermore, the user interface is used to display in real time the respiratory state, respiratory rate, respiratory depth and airway pressure monitored by the airway sensor, so as to adjust or set new stimulation parameters through real-time display information.

[0088] In this embodiment, the user interface includes a variety of input methods such as a touch screen, buttons, and knobs, and a display screen as an output method. The parameters of the electrical stimulation signal can be adjusted through the user interface to be set according to the patient's specific conditions and the doctor's advice. The airway sensor transmits the monitored data such as respiratory status, respiratory rate, respiratory depth, and airway pressure to the intelligent controller through a signal and displays it in real time through the display screen.

[0089] In an optional manner, the system further includes a safety monitoring module;

[0090] The safety monitoring module is connected to the intelligent controller, the electrode array and the airway sensor;

[0091] The safety monitoring module is used to monitor the current, voltage and airway pressure during the electrical stimulation process in real time. When one of the current, voltage and airway pressure exceeds a preset safety value, the electrical stimulation signal is automatically cut off or adjusted immediately.

[0092] In this embodiment, the safety monitoring module monitors the current, voltage and airway pressure during the electrical stimulation process in real time, and automatically cuts off or adjusts the electrical stimulation signal immediately without human intervention, thereby preventing potential risks caused by excessive electrical stimulation or abnormal airway pressure.

[0093] In an optional manner, the material of the guide wire channel is polytetrafluoroethylene or polyurethane;

[0094] The insulating layer is made of polyvinyl chloride and covers the outside of the electrode array and the guide wire channel;

[0095] The sealing structure is made of thermoplastic elastomer and is arranged at the end or connection of the intelligent intravenous catheter.

[0096] According to the scheme provided by the present invention, it includes an intelligent intravenous catheter, which integrates at least one electrode array; the electrode array is distributed along the length direction of the intelligent intravenous catheter in a spiral arrangement, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrode electrically stimulates the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guide wire channel, an insulating layer and a sealing structure for guiding the electrode array and signal transmission; an intelligent controller is connected to the intelligent intravenous catheter, and is used to send a control electrical stimulation signal to the electrode array on the intelligent intravenous catheter; the electrical stimulation signal includes freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform; an airway sensor, one end of which is connected to the patient's airway, and the other end is connected to the intelligent controller, which is used to monitor the patient's respiratory state, respiratory frequency, respiratory depth and airway pressure in real time. The present invention sets a spirally arranged electrode array on the intelligent intravenous catheter, which can accurately stimulate the target phrenic nerve area, and can more effectively activate and exercise the diaphragm muscle through multiple independent and independently controllable micro-stimulation electrodes. The intelligent controller sends electrical stimulation signals containing freely adjustable stimulation parameters, which improves the effectiveness of treatment. The airway sensor monitors the patient's breathing status, respiratory rate, respiratory depth, and airway pressure physiological parameters in real time, so that the feedback process of electrical stimulation can be grasped in time.

[0097] Figure 7 The schematic diagram of the structure of the computing device embodiment of the present invention is shown. The specific embodiment of the present invention does not limit the specific implementation of the computing device.

[0098] like Figure 7 As shown, the computing device may include: a processor (processor) 702 , a communications interface (Communications Interface) 704 , a memory (memory) 706 , and a communication bus 708 .

[0099] The processor 702, the communication interface 704, and the memory 706 communicate with each other via a communication bus 708. The communication interface 704 is used to communicate with other devices such as a client or other server network elements. The processor 702 is used to execute a program 710, which can specifically execute the relevant steps in the above-mentioned embodiment of the intelligent intravenous catheter system for diaphragmatic electrical stimulation via a vein.

[0100] Specifically, the program 710 may include program codes, which include computer operation instructions.

[0101] The processor 702 may be a central processing unit (CPU), or an application-specific integrated circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of the present invention. The one or more processors included in the computing device may be processors of the same type, such as one or more CPUs; or processors of different types, such as one or more CPUs and one or more ASICs.

[0102] The memory 706 is used to store the program 710. The memory 706 may include a high-speed RAM memory, and may also include a non-volatile memory (non-volatile memory), such as at least one disk memory.

[0103] According to the scheme provided by the present invention, it includes an intelligent intravenous catheter, which integrates at least one electrode array; the electrode array is distributed along the length direction of the intelligent intravenous catheter in a spiral arrangement, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrode electrically stimulates the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guide wire channel, an insulating layer and a sealing structure for guiding the electrode array and signal transmission; an intelligent controller is connected to the intelligent intravenous catheter, and is used to send a control electrical stimulation signal to the electrode array on the intelligent intravenous catheter; the electrical stimulation signal includes freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform; an airway sensor, one end of which is connected to the patient's airway, and the other end is connected to the intelligent controller, which is used to monitor the patient's respiratory state, respiratory frequency, respiratory depth and airway pressure in real time. The present invention sets a spirally arranged electrode array on the intelligent intravenous catheter, which can accurately stimulate the target phrenic nerve area, and can more effectively activate and exercise the diaphragm muscle through multiple independent and independently controllable micro-stimulation electrodes. The intelligent controller sends electrical stimulation signals containing freely adjustable stimulation parameters, which improves the effectiveness of treatment. The airway sensor monitors the patient's breathing status, respiratory rate, respiratory depth, and airway pressure physiological parameters in real time, so that the feedback process of electrical stimulation can be grasped in time.

[0104] Those skilled in the art will appreciate that the modules in the devices in the embodiments can be adaptively changed and set in one or more devices different from the embodiments. The modules or units or components in the embodiments can be combined into one module or unit or component, and in addition they can be divided into multiple submodules or subunits or subcomponents. Except that at least some of such features and / or processes or units are mutually exclusive, all features disclosed in this specification (including the accompanying claims, abstracts and drawings) and all processes or units of any method or device disclosed in this manner can be combined in any combination. Unless otherwise explicitly stated, each feature disclosed in this specification (including the accompanying claims, abstracts and drawings) can be replaced by an alternative feature that provides the same, equivalent or similar purpose. In addition, those skilled in the art will appreciate that although some embodiments herein include certain features included in other embodiments but not other features, the combination of features of different embodiments means being within the scope of the present invention and forming different embodiments. For example, in the following claims, any one of the claimed embodiments can be used in any combination. The present invention can be implemented by hardware including several different elements and by appropriately programmed computers. In a unit claim that lists several means, several of these means may be embodied by the same hardware item. The steps in the above embodiments should not be understood as limiting the execution order unless otherwise specified.

Claims

1. An intelligent intravenous catheter system for diaphragmatic electrical stimulation via a vein, characterized in that: include: An intelligent intravenous catheter, integrating at least one electrode array; the electrode array is distributed in a spiral arrangement along the length of the intelligent intravenous catheter, and includes at least 30 independent and independently controllable micro-stimulation electrodes; the stimulation electrodes electrically stimulate the target phrenic nerve area to activate and exercise the diaphragm muscle; the interior of the intelligent intravenous catheter includes a guidewire channel, an insulating layer, and a sealing structure for guiding the electrode array and signal transmission; An intelligent controller connected to the intelligent venous catheter, and used to send a control electrical stimulation signal to the electrode array on the intelligent venous catheter; the electrical stimulation signal includes freely adjustable stimulation parameters, wherein the stimulation parameters include current intensity, pulse width, stimulation frequency, stimulation mode and stimulation waveform; The airway sensor has one end connected to the patient's airway and the other end connected to the intelligent controller, and is used to monitor the patient's breathing state, breathing frequency, breathing depth and airway pressure in real time.

2. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 1, characterized in that: The electrode array is connected to a high-efficiency conductive path through an insulating material to form a closed-loop circuit structure, and the closed-loop circuit structure is used to automatically adjust stimulation parameters according to real-time feedback from an airway sensor.

3. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 2, characterized in that: The closed-loop circuit structure comprises: A signal generator, connected to the signal amplifier via an SPI / I2 C interface, for generating an electrical stimulation signal, wherein the electrical stimulation signal includes a set current intensity, a pulse width, a stimulation frequency, a stimulation mode, and a stimulation waveform; A signal amplifier, connected to the multiplexer via an analog signal line, transmits the amplified signal to the multiplexer to generate a weak signal to drive the electrode array to perform electrical stimulation; A multiplexer connected to the isolation circuit via an analog signal line, and the isolation circuit is connected to the electrode array via an isolation signal line; used to selectively transmit the amplified signal to each electrode to independently control the multiple electrodes; An isolation circuit, connected to the electrode array via an isolation signal line, transmits the isolated signal to the electrode array; and is used to provide electrical isolation to prevent current from flowing directly through the patient's body; An electrode array for converting received electrical stimulation signals into electric currents to act on the target phrenic nerve area to activate and exercise the diaphragm muscle; A feedback circuit is connected to the airway sensor via an analog signal line, and is used to receive the respiratory state, respiratory frequency, respiratory depth, and airway pressure monitored in real time by the airway sensor and convert them into electrical signals; The microcontroller is connected to the signal generator via an SPI / I2 C interface, and is used to receive information from the feedback circuit and send instructions to the signal generator according to a preset control algorithm to adjust the parameters of the electrical stimulation signal.

4. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 3, characterized in that: After the signal generator generates the electrical stimulation signal, the method further comprises: The electrical stimulation signal generated by the signal generator is adjusted, wherein the adjustment formula of the electrical stimulation signal is: Among them, U(t) is the adjusted electrical stimulation parameter P t Output control quantity; K p is the proportional gain; K i is the integral gain; K d is the differential gain; e(t) is the error signal, that is, the deviation between the actual measured value and the expected value; t is the time.

5. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 3, characterized in that: The multiplexer selects electrodes for stimulation using a polling method, including the following steps: Initialize electrode selection sequence; Cycle through the electrode selection sequence, selecting each electrode for stimulation in turn; Switch to the next electrode according to the preset stimulation time and interval.

6. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 3, characterized in that: The feedback circuit also includes an analog-to-digital converter, and the interpolation calculation formula of the analog-to-digital converter to improve the signal resolution is: Among them, Interpolated value is the signal value after interpolation; value1 and value2 are the signal values ​​of two known adjacent sampling points; ADC Code is the current ADC code value; Code1 and Code2 are the ADC code values ​​corresponding to value1 and value2.

7. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 1, characterized in that: The intelligent controller also includes a user interface; The user interface is used to receive input or adjust parameters of the electrical stimulation signal; Furthermore, the user interface is used to display in real time the respiratory state, respiratory rate, respiratory depth and airway pressure monitored by the airway sensor, so as to adjust or set new stimulation parameters through real-time display information.

8. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 1, characterized in that: The system also includes a safety monitoring module; The safety monitoring module is connected to the intelligent controller, the electrode array and the airway sensor; The safety monitoring module is used to monitor the current, voltage and airway pressure during the electrical stimulation process in real time. When one of the current, voltage and airway pressure exceeds a preset safety value, the electrical stimulation signal is automatically cut off or adjusted immediately.

9. The intelligent intravenous catheter system for diaphragmatic electrical stimulation via vein according to claim 1, characterized in that: The material of the guide wire channel is polytetrafluoroethylene or polyurethane; The insulating layer is made of polyvinyl chloride and covers the outside of the electrode array and the guide wire channel; The sealing structure is made of thermoplastic elastomer and is arranged at the end or connection of the intelligent intravenous catheter.

10. A computing device comprising: A processor, a memory, a communication interface and a communication bus, wherein the processor, the memory and the communication interface communicate with each other via the communication bus; The memory is used to store at least one executable instruction, and the executable instruction enables the processor to execute operations corresponding to the above-mentioned intelligent intravenous catheter system for diaphragm electrical stimulation through the vein.

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