Low-irritation selective cleaning shampoo and preparation method thereof

Abstract

The invention relates to low-irritation selective cleaning shampoo and a preparation method thereof, and belongs to the technical field of shampoo. The low-irritation selective cleaning shampoo is prepared from the following components: an amino acid surfactant, an ampholytic surfactant and a soothing agent, the amino acid surfactant is prepared from sodium lauroyl methyl amino propionate and sodium cocamidopropionate; the amphoteric surfactant is prepared from sodium lauroamphoacetate, disodium cocoamphodipropionate and lauramide propyl hydroxy sulfobetaine; the sodium lauroamphoacetate, the disodium cocoamphodipropionate and the lauramide propyl hydroxy sulfobetaine are used as raw materials; the soothing agent is prepared by taking hydrolyzed corn starch, a chamomile extract and heliotropin as raw materials. By compounding multiple surfactants and adding the soothing agent, PPG-2 hydroxyethyl cocamide and propylene glycol laurate as thickeners, the shampoo has good foamability and rich and stable foam, the decontamination ability of the shampoo is improved, the irritation and damage to hair can be reduced, the overall mildness of the shampoo is reduced, and the shampoo is particularly suitable for being used on sensitive scalp.

Description

Technical Field

[0001] The invention belongs to the technical field of shampoo and relates to a low-irritation selective cleaning shampoo and a preparation method thereof. Background Art

[0002] In today's market, silicone-free shampoos have become a popular choice, and these shampoos are mainly based on amino acid surfactants. By compounding some traditional surfactants, such as lauryl sulfate (AS) and laureth sulfate (AES), these products attempt to provide a gentle cleansing experience. However, this compounding method also brings some challenges, especially the relatively weak detergency. In addition, although amino acid surfactants are gentler on the scalp, their foaming properties are generally not as good as traditional surfactants, which may affect the user experience. At the same time, although anionic surfactants have strong cleaning power, they are more harmful to the scalp sebum, which is also a problem that requires special attention when designing silicone-free shampoos.

[0003] As a natural ingredient, chamomile extract has been increasingly used in shampoos in recent years. Chamomile extract is rich in a variety of beneficial ingredients, such as flavonoids, volatile oils and polysaccharides, which work together to provide multiple care effects for the scalp and hair. Apigenin is a natural flavonoid compound found in chamomile extract. Apigenin has significant anti-inflammatory effects and can effectively reduce inflammatory responses, thereby relieving pain and discomfort caused by inflammation. Secondly, apigenin also has antioxidant properties, which can remove free radicals in the body, protect cells from oxidative damage, and delay the aging process. In addition, apigenin also has antibacterial and antiviral properties, which can inhibit the growth of a variety of bacteria and viruses and enhance the body's immunity. Finally, apigenin in chamomile extract also has a calming and tranquilizing effect, which can help relieve anxiety and tension and improve sleep quality. Therefore, the multiple effects of apigenin in chamomile extract make it a very valuable natural ingredient. However, apigenin has particularly poor solubility, is almost insoluble in water, and has low solubility in organic solvents, resulting in low bioavailability. Summary of the invention

[0004] The purpose of the present invention is to provide a low-irritation selective cleansing shampoo and a preparation method thereof, and to provide a low-irritation high-viscosity shampoo that has the ability to remove dirt and protein while not damaging sebum. The present invention compounded a plurality of surfactants and added a soothing agent to make the shampoo have good foaming properties, rich and stable foam, improve the dirt removal ability of the shampoo, and reduce irritation and damage to hair. The shampoo is mild overall and is particularly suitable for use on sensitive scalps.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0007]

[0008] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9-10:1.2-1.6;

[0009] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauramide propyl hydroxysulfobetaine in a mass ratio of 4.0-5.2:10-13:8-10.

[0010] The present invention discloses that the preparation of the soothing agent comprises the following steps:

[0011] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0012] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0013] As a preferred technical solution of the present invention, in step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 60-80:0.42-0.50:6.0-7.0.

[0014] As a preferred technical solution of the present invention, in step 1), the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.5-5.0:90-96; the stirring and mixing is performed at a speed of 500-800 r / min for 15-20 min; and the ultrasonic mixing is performed at an ultrasonic frequency of 1100-1300 W for 1.0-1.5 h.

[0015] As a preferred technical solution of the present invention, in step 2), the stirring and heat preservation is stirring at a temperature of 65-70°C for 4-5h; the centrifugation is centrifugation to remove the solvent; the washing is washing with anhydrous ethanol for 3 times; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 5-7:20-25.

[0016] As a preferred technical solution of the present invention, in step 2), the mass ratio of the mixed solution, pretreated chamomile extract, new heliotropin solution and hydrolyzed corn starch is 80-85:2.4-3.0:35-40:12; the hydrolyzed corn starch is purchased from Shanghai Ruimu Chemical Technology Co., Ltd.

[0017] As a preferred technical solution of the present invention, the pre-treated chamomile extract is freeze-dried to make the chamomile extract into powder.

[0018] The invention discloses a method for preparing a low-irritation selective cleaning shampoo, which comprises the following steps:

[0019] S1. Heat distilled water to 75-85°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 10-15 minutes, cool to 45-50°C, add soothing agent and stir for 5-8 minutes to obtain a mixed solution;

[0020] S2. Then, EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid are added to the mixed solution and stirred for 30-45 minutes to prepare a cleansing shampoo.

[0021] Beneficial effects of the present invention:

[0022] (1) Chamomile extract contains the natural flavonoid compound apigenin, which has anti-inflammatory, antibacterial, antiviral and other biological activities; the present invention alleviates skin erythema by adding chamomile extract to reduce the production and release of pro-inflammatory factors, and apigenin helps to inhibit the release of histamine, thereby reducing skin erythema.

[0023] (2) The present invention uses sodium lauroyl methylaminopropionate, sodium cocoamidopropionate, sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroamidopropyl hydroxysulfobetaine as surfactants, and controls the amount of each component, so that the shampoo has low irritation, good foaming property, rich and stable foam, and excellent detergency, but will not over-degrease.

[0024] (3) PPG-2 hydroxyethyl cocamide and propylene glycol laurate are thickeners, which make the shampoo have good foaming properties and rich and stable foam.

[0025] (4) NaCl content <0.1%, low irritation. DETAILED DESCRIPTION

[0026] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0027] Example 1

[0028] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0029]

[0030]

[0031] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9:1.2.

[0032] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroylamidopropyl hydroxysulfobetaine in a mass ratio of 4.0:10:8.

[0033] The preparation of the soothing agent comprises the following steps:

[0034] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0035] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0036] Wherein, the pre-treated chamomile extract is freeze-dried to make a powder;

[0037] In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 60:0.42:6.0; the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.5:90; the stirring and mixing is performed at a speed of 500 r / min for 15 minutes; and the ultrasonic mixing is performed at an ultrasonic frequency of 1100 W for 1.0 hour.

[0038] In step 2), the stirring and heat preservation is stirring at 65°C for 4 hours; the centrifugation is centrifugal removal of the solvent; the washing is washing 3 times with anhydrous ethanol; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 5:20; the mass ratio of the mixed solution, pretreated chamomile extract, heliotropin solution and hydrolyzed corn starch is 80:2.4:35:12.

[0039] A method for preparing a low-irritation selective cleansing shampoo comprises the following steps:

[0040] S1. Heat distilled water to 75°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 10 minutes, cool to 45°C, add soothing agent and stir for 5 minutes to obtain a mixed solution;

[0041] S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 30 minutes to obtain the mixture.

[0042] Example 2

[0043] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0044]

[0045] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9.2:1.3.

[0046] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroylamidopropyl hydroxysulfobetaine in a mass ratio of 4.3:11:8.5.

[0047] The preparation of the soothing agent comprises the following steps:

[0048] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0049] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0050] Wherein, the pre-treated chamomile extract is freeze-dried to make a powder;

[0051] In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 65:0.44:6.2; the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.6:92; the stirring and mixing is performed at a speed of 575 r / min for 16 min; and the ultrasonic mixing is performed at an ultrasonic frequency of 1150 W for 1.2 h.

[0052] In step 2), the stirring and heat preservation is stirring at 66°C for 4.2 hours; the centrifugation is centrifugal removal of the solvent; the washing is washing 3 times with anhydrous ethanol; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 5.5:21; the mass ratio of the mixed solution, pretreated chamomile extract, heliotropin solution and hydrolyzed corn starch is 81:2.6:36:12.

[0053] A method for preparing a low-irritation selective cleansing shampoo comprises the following steps:

[0054] S1. Heat distilled water to 78°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 11 minutes, cool to 46°C, add soothing agent and stir for 5.8 minutes to obtain a mixed solution;

[0055] S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 34 minutes to obtain the mixture.

[0056] Example 3

[0057] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0058]

[0059] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9.5:1.4.

[0060] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroylamidopropyl hydroxysulfobetaine in a mass ratio of 4.6:11.5:9.

[0061] The preparation of the soothing agent comprises the following steps:

[0062] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0063] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0064] Wherein, the pre-treated chamomile extract is freeze-dried to make a powder;

[0065] In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 70:0.46:6.5; the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.8:93; the stirring and mixing is performed at a speed of 650 r / min for 18 min; and the ultrasonic mixing is performed at an ultrasonic frequency of 1200 W for 1.2 h.

[0066] In step 2), the stirring and heat preservation is stirring at 68°C for 4.5 hours; the centrifugation is centrifugal removal of the solvent; the washing is washing 3 times with anhydrous ethanol; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 6:22; the mass ratio of the mixed solution, pretreated chamomile extract, heliotropin solution and hydrolyzed corn starch is 82:2.7:38:12.

[0067] A method for preparing a low-irritation selective cleansing shampoo comprises the following steps:

[0068] S1. Heat distilled water to 80°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 12 minutes, cool to 48°C, add soothing agent and stir for 6.5 minutes to obtain a mixed solution;

[0069] S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 38 minutes to obtain the mixture.

[0070] Example 4

[0071] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0072]

[0073]

[0074] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9.8:1.5.

[0075] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroylamidopropyl hydroxysulfobetaine in a mass ratio of 4.9:12.2:9.5.

[0076] The preparation of the soothing agent comprises the following steps:

[0077] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0078] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0079] Wherein, the pre-treated chamomile extract is freeze-dried to make a powder;

[0080] In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 75:0.48:6.8; the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.9:94; the stirring and mixing is performed at a speed of 725 r / min for 19 minutes; and the ultrasonic mixing is performed at an ultrasonic frequency of 1250 W for 1.4 hours.

[0081] In step 2), the stirring and heat preservation is stirring at 69°C for 4.8 hours; the centrifugation is centrifugal removal of the solvent; the washing is washing 3 times with anhydrous ethanol; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 6.5:24; the mass ratio of the mixed solution, pretreated chamomile extract, heliotropin solution and hydrolyzed corn starch is 84:2.8:39:12.

[0082] A method for preparing a low-irritation selective cleansing shampoo comprises the following steps:

[0083] S1. Heat distilled water to 82°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 14 minutes, cool to 49°C, add soothing agent and stir for 7 minutes to obtain a mixed solution;

[0084] S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 41 minutes to obtain the mixture.

[0085] Example 5

[0086] A low-irritation selective cleansing shampoo comprises the following components by weight:

[0087]

[0088] The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 10:1.6.

[0089] The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroylamidopropyl hydroxysulfobetaine in a mass ratio of 5.2:13:10.

[0090] The preparation of the soothing agent comprises the following steps:

[0091] 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained;

[0092] 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

[0093] Wherein, the pre-treated chamomile extract is freeze-dried to make a powder;

[0094] In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 80:0.50:7.0; the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 5.0:96; the stirring and mixing is performed at a speed of 800 r / min for 20 minutes; and the ultrasonic mixing is performed at an ultrasonic frequency of 1300 W for 1.5 hours.

[0095] In step 2), the stirring and heat preservation is stirring at 70°C for 5 hours; the centrifugation is centrifugal removal of the solvent; the washing is washing 3 times with anhydrous ethanol; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 7:25; the mass ratio of the mixed solution, pretreated chamomile extract, heliotropin solution and hydrolyzed corn starch is 85:3.0:40:12.

[0096] A method for preparing a low-irritation selective cleansing shampoo comprises the following steps:

[0097] S1. Heat distilled water to 85°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 15 minutes, cool to 50°C, add soothing agent and stir for 8 minutes to obtain a mixed solution;

[0098] S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 45 minutes to obtain the mixture.

[0099] Comparative Example 1

[0100] Compared with Example 5, the difference in Comparative Example 1 is that sodium lauroyl methylamino propionate is used instead of sodium cocoamido propionate, and the other components, preparation steps and parameters are the same.

[0101] Comparative Example 2

[0102] Compared with Example 5, the difference in Comparative Example 2 is that sodium cocoamidopropionate is used instead of sodium lauroylmethylaminopropionate, and the other components, preparation steps and parameters are the same.

[0103] Comparative Example 3

[0104] Compared with Example 5, Comparative Example 3 is different in that sodium lauroamphoacetate is used instead of lauramidopropyl hydroxysulfobetaine, and the other components, preparation steps and parameters are the same.

[0105] Comparative Example 4

[0106] Compared with Example 5, the difference in Comparative Example 4 is that disodium cocoamphodipropionate is used instead of lauramidopropyl hydroxysulfobetaine, and the other components, preparation steps and parameters are the same.

[0107] Comparative Example 5

[0108] Compared with Example 5, the difference of Comparative Example 5 is that the amphoteric surfactant is lauroyl hydroxysulfobetaine, that is, lauroyl hydroxysulfobetaine is used instead of sodium lauroamphoacetate and disodium cocoamphodipropionate, and the other components, preparation steps and parameters are the same.

[0109] Comparative Example 6

[0110] Compared with Example 5, Comparative Example 6 is different in that carboxymethyl chitosan is used instead of hydroxyethyl cellulose, and the other components, preparation steps and parameters are the same.

[0111] Comparative Example 7

[0112] Compared with Example 5, Comparative Example 7 is different in that carboxymethyl chitosan is not used, and the other components, preparation steps and parameters are the same.

[0113] Comparative Example 8

[0114] Compared with Example 5, the difference in Comparative Example 8 is that no neoheliotropin is used, and the remaining components, preparation steps and parameters are the same.

[0115] Comparative Example 9

[0116] Compared with Example 5, Comparative Example 9 is different in that step 1);

[0117] Step 1) After ultrasonically mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and stirred and mixed, and after cooling to room temperature, a mixed solution is obtained; the remaining components, preparation steps and parameters are the same

[0118] The shampoos prepared in Examples 1-5 and Comparative Examples 1-9 were subjected to the following performance tests respectively.

[0119] Shampoo foaming performance test

[0120] Refer to the method in "Simple Rotational Foam Test Operating Procedure for Surfactants and Detergents" File No.: HS-YY-AW-20231101 to test the foam height (5mm) after 30 seconds, the foam height after 3 minutes, and the foam height after 5 minutes.

[0121] Experimental methods

[0122] Experimental instrument: Simple rotating foam instrument

[0123] Experimental steps:

[0124] 1: Accurately weigh 5g of the raw material sample to be tested;

[0125] 2: Dilute the sample with deionized water in a 500ml beaker to a 1% solution;

[0126] 3: Transfer the solution to the dilution to be tested in a 500 ml volumetric flask and place it in a 40°C water bath for 20 minutes;

[0127] 4: Rinse the measuring cylinder of the simple rotating foam instrument twice with 50 ml of the diluent to be tested;

[0128] 5: Use a 500ml measuring cylinder to accurately measure 200ml of the diluent to be tested and put it into the measuring cylinder of the simple rotating foam instrument, and lock the measuring cylinder fastener;

[0129] 6: Set the rotating foam instrument to rotate forward at a speed of 20r / min, and time it for 1min. Press the stop button to stop the simple rotating foam instrument and start timing.

[0130] 7: Read the total volume of the upper foam and liquid and the lower liquid volume of the simple rotating foam meter at 30s, 3min and 5min.

[0131] 8: Subtract the liquid volume value from the total volume value to get the rotational foam volume of the sample to be tested at 30s, 3min, and 5min.

[0132] The experimental results are shown in Table 1;

[0133] Table 1

[0134] 30s foam height (mL) 3min foam height (mL) 5min foam height (mL) Example 1 640 630 628 Example 2 643 632 630 Example 3 642 631 628 Example 4 645 636 633 Example 5 647 639 637 Comparative Example 1 575 551 535 Comparative Example 2 596 575 564 Comparative Example 3 571 546 530 Comparative Example 4 572 548 532 Comparative Example 5 568 543 528 Comparative Example 6 575 549 534 Comparative Example 7 565 534 515 Comparative Example 8 567 537 520 Comparative Example 9 581 555 538

[0135] From the test results in Table 1, it can be seen that compared with Comparative Examples 1-9, the shampoo prepared in Examples 1-5 of the present invention has significant bubble effect and stable foam, and has excellent decontamination ability.

[0136] Histamine soothing and anti-itching test

[0137] 60 healthy volunteers were randomly divided into 6 groups, and the test results were calculated as the arithmetic mean.

[0138] Test measurement parameters: skin redness (visual scoring);

[0139] Test samples: shampoos prepared in Examples 1 / 3 / 5 and Comparative Examples 6-9;

[0140] Test method: add histamine hydrochloride (0.01 g / mL) to the skin test site. After 5 minutes, the skin will swell. 2 ), comparative product (0.01g / cm 2 ) and no product (blank), and the redness and swelling of the test site were measured after 0 minutes, 30 minutes, and 90 minutes. The specific test results are shown in Table 2. (The result 0 means no redness and swelling, and the larger the value from 1 to 9, the more obvious the redness and swelling;)

[0141] Table 2

[0142] 0 minutes 30 minutes 90 minutes Blank group 9 8 4 Example 1 9 4 0 Example 3 9 5 0 Example 5 9 4 0 Comparative Example 6 9 6 2 Comparative Example 7 9 7 4 Comparative Example 8 9 6 3 Comparative Example 9 9 6 2

[0143] From the test results in Table 2, it can be seen that the shampoo prepared by the present invention has the effect of soothing and relieving itching.

[0144] By comparing Examples 1-5 with Comparative Examples 1-9, combined with analysis of Tables 1 and 2, it can be seen that the present invention uses sodium lauroyl methylaminopropionate, sodium cocoamidopropionate, sodium lauroamphoacetate, disodium cocoamphodipropionate and lauroamidopropyl hydroxysulfobetaine as surfactants, and controls the amount of each component, so that the shampoo has good foaming properties, rich and stable foam, and excellent detergency, but will not over-degrease, and the shampoo has a soothing and antipruritic effect.

[0145] Sodium cocamidopropionate is a mild amino acid surfactant that can provide rich foam and increase the mildness of shampoo. Sodium lauroylmethylaminopropionate, as an auxiliary surfactant, can enhance the foaming ability of sodium cocamidopropionate and improve the stability of foam. Adding amphoteric surfactants can further enhance the foam quality of shampoo, making the foam more delicate and lasting. The combined use can improve the overall mildness of shampoo, which is especially suitable for sensitive scalp. Amphoteric surfactants, as foam enhancers and stabilizers, can reduce the surface tension of water, thereby helping amino acid surfactants to form rich and delicate foam and make the foam more stable and lasting. In addition, amphoteric surfactants also have good skin mildness and cleaning ability, which helps to remove grease and dirt on hair and scalp, while reducing irritation and damage to hair. Heating amphoteric surfactants can not only greatly improve the solubility of amino acid surfactants at low pH, but also form mixed micelles and mutually entangled structures. The foam formed has a higher water content and a higher liquid film strength, so it has higher foam stability.

[0146] Hydroxyethyl cellulose is a cellulose derivative that can form a stable three-dimensional network structure in water. This structure helps to increase the viscosity of the shampoo, thereby providing the required thickness and fluidity. Hydroxyethyl cellulose is less irritating to the skin and scalp and is suitable for sensitive skin. It can not only reduce the surface tension of the system, but also help amino acid surfactants and amphoteric surfactants to more easily generate and stabilize foam, thereby reducing the merging and breaking of foam, producing more delicate and lasting foam, and providing better cleaning effects.

[0147] The present invention forms a composite carrier with hydroxyethyl cellulose and degraded carboxymethyl chitosan small molecules to obtain a richer pore structure, improve stability, and promote the attachment of chamomile extract to the composite carrier under the action of hydrogen bonds. Then, new hediocarboxaldehyde is used to form a Schiff base compound with better stability. The Schiff base structure will be arranged in a directional manner on the water surface, so that water molecules are more likely to aggregate and form weaker surface intermolecular forces, thereby reducing the surface tension of water molecules, which reduces the energy required to form bubbles, so that bubbles are more likely to be generated. The nitrogen atoms in the Schiff base structure can form hydrogen bonds or Schiff base reactions with amino acid residues in protein molecules, which may lead to changes in the protein structure, making it easier to be decomposed and removed by detergents, thereby improving the decontamination ability of shampoo.

[0148] Chamomile extract contains apigenin, which has anti-inflammatory, antibacterial, antiviral and other biological activities. The present invention improves the stability of the composite carrier by adding chamomile extract, making the structure of apigenin itself not easily destroyed, and at the same time, increases the fat solubility of apigenin, thereby promoting it to pass through the cell membrane and enter the cell, so that it can more effectively penetrate the scalp and exert its effect.

[0149] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A low-irritation selective cleansing shampoo, characterized in that: The components include the following by weight: Amino acid surfactant 20-24 parts 21-30 parts of amphoteric surfactant 4-6 portions of soothing agent; The amino acid surfactant is prepared by mixing sodium lauroyl methylaminopropionate and sodium cocoamidopropionate in a mass ratio of 9-10:1.2-1.6; The amphoteric surfactant is prepared by mixing sodium lauroamphoacetate, disodium cocoamphodipropionate and lauramide propyl hydroxysulfobetaine in a mass ratio of 4.0-5.2:10-13:8-10.

2. A low-irritation selective cleansing shampoo according to claim 1, characterized in that: The following components are also included by weight:

3. A low-irritation selective cleansing shampoo according to claim 2, characterized in that: The preparation of the soothing agent comprises the following steps: 1) After stirring and mixing the acetic acid solution and hydroxyethyl cellulose, carboxymethyl chitosan is added and ultrasonically mixed, and after cooling to room temperature, a mixed solution is obtained; 2) After the mixed solution and the pretreated chamomile extract are stirred at high speed, the new chamomile aldehyde solution is added, stirred and kept warm, centrifuged, washed and freeze-dried, and hydrolyzed corn starch is added and mixed to obtain the product.

4. A low-irritation selective cleansing shampoo according to claim 3, characterized in that: In step 1), the mass ratio of the acetic acid solution, hydroxyethyl cellulose and carboxymethyl chitosan is 60-80: 0.42-0.50：6.0-7.0。 5. A low-irritation selective cleansing shampoo according to claim 3, characterized in that: In step 1), the acetic acid solution is prepared by mixing acetic acid and deionized water in a mass ratio of 4.5-5.0:90-96; the stirring and mixing is performed at a speed of 500-800 r / min for 15-20 min; and the ultrasonic mixing is performed at an ultrasonic frequency of 1100-1300 W for 1.0-1.5 h.

6. A low-irritation selective cleansing shampoo according to claim 3, characterized in that: In step 2), the stirring and heat preservation is stirring at 65-70°C for 4-5h; the centrifugation is centrifugation to remove the solvent; the washing is washing with anhydrous ethanol for 3 times; the heliotropin solution is prepared by mixing heliotropin and ethanol in a mass ratio of 5-7:20-25.

7. A low-irritation selective cleansing shampoo according to claim 3, characterized in that: In step 2), the mass ratio of the mixed solution, the pretreated chamomile extract, the new jasminoid solution and the hydrolyzed corn starch is 80-85: 2.4-3.0：35-40：12。 8. The low-irritation selective cleansing shampoo according to claim 3, characterized in that: The pretreated chamomile extract is prepared by freeze-drying the chamomile extract to form a powder.

9. A method for preparing the low-irritation selective cleansing shampoo according to any one of claims 2 to 8, characterized in that: The preparation method comprises the following steps: S1. Heat distilled water to 75-85°C, then add amino acid surfactant and amphoteric surfactant in sequence, stir and keep warm for 10-15 minutes, cool to 45-50°C, add soothing agent and stir for 5-8 minutes to obtain a mixed solution; S2. Then, add EDTA-4Na, polyquaternium-67, PPG-2 hydroxyethyl cocamide, p-hydroxyacetophenone, polylysine and cationic hyaluronic acid to the mixed solution and stir for 30-45 minutes to prepare a cleansing shampoo.

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