Clindamycin hydrochloride separation device

Abstract

The invention discloses a clindamycin hydrochloride separation device, and particularly relates to the technical field of separation devices, the clindamycin hydrochloride separation device comprises a support frame, a flow guide separation assembly is arranged on the support frame, the flow guide separation assembly comprises a separator main body arranged on the support frame, and a first separation filter plate is clamped in the middle of the separator main body. Raw materials are added to the supporting inclined plate and gathered together through the flow guide inclined plate, so that the raw materials easily flow into the frame opening and are easily filtered firstly through the filter belt, and meanwhile, the raw materials filtered through the filter belt flow into the supporting inclined plate and are conveyed into the mixing box through the filter, so that the function of firstly separating the raw materials is achieved; and the third separation filter plate separates and filters the raw materials again, so that the separated raw materials are accumulated on the first separation filter plate to cause a poor separation treatment effect, impurities are easily separated on the third separation filter plate, and diversity and continuity during raw material separation are realized.

Description

Technical Field

[0001] The present invention relates to the technical field of separation devices, and more specifically, to a clindamycin hydrochloride separation device. Background Art

[0002] The separation device is a device for realizing the separation process. According to the structure, it can be divided into two categories: plate tower and packed tower. Commonly used ones include bubble tower, floating valve tower, sieve plate tower, leaching plate tower, packed tower, etc., which are mainly used in distillation, absorption, extraction, adsorption and other operations. Various impurities may be generated during the preparation of clindamycin hydrochloride, and these impurities may affect the purity and quality of the product. Through the separation operation, these impurities can be effectively removed to improve the purity of the product. Through the separation operation, the reaction system can be optimized and controlled to improve production efficiency. For example, during the preparation process, the by-products or unreacted raw materials produced by the reaction can be removed in time through the separation operation, thereby promoting the reaction in the positive direction and improving the yield and quality of the product.

[0003] Among them, the patent with announcement number CN105949253A discloses a method for purifying clindamycin hydrochloride, and the process includes: the process steps include: adsorbing the clindamycin hydrochloride adduct reaction solution with a macroporous resin, analyzing with methanol, concentrating the obtained analytical solution by vacuum distillation, then dissolving with butyl acetate solvent, and then hydrolyzing with alkali, extracting with alkali, and decolorizing with activated carbon to obtain a clindamycin alkali decolorized solution, crystallizing the clindamycin hydrochloride alcoholate, and converting the crystals with acetone to obtain the clindamycin hydrochloride product; When the structure is in use, the macroporous resin is used to purify the clindamycin hydrochloride adduct reaction liquid, which is beneficial to the alkaline hydrolysis and alkaline extraction separation process, reduces the emulsification effect, increases the synthesis yield of clindamycin hydrochloride by more than 6%, reduces solvent loss, reduces production costs, and increases economic benefits. However, the structure is not easy to filter and separate impurities inside the material during preparation, which affects the preparation accuracy. Summary of the invention

[0004] In order to overcome the above defects of the prior art, the present invention provides a clindamycin hydrochloride separation device, aiming to solve the problems raised in the above background technology.

[0005] The present invention provides the following technical solution: a clindamycin hydrochloride separation device, comprising a support frame, on which a diversion separation component is arranged; The flow guide separation assembly comprises a separator body arranged on a support frame, a first separation filter plate is clamped in the middle of the separator body, a vertical cross-section of the first separation filter plate is set to be conical, a mixing box is fixedly arranged at the bottom of the separator body, and a second separation filter plate is clamped at the bottom of the inner cavity of the mixing box; A support inclined plate for guiding materials is arranged on one side of the surface of the separator body, a filter is fixedly arranged on one side of the support inclined plate, and one end of the filter is connected to the mixing box; The support inclined plate is internally rotatably connected to two conveying rollers, and the conveying rollers are transmission-connected to a filter belt for filtering.

[0006] It can be seen that in the above technical solution, the raw materials are added to the supporting inclined plate and gathered by the guide inclined plate, which makes it easy for the raw materials to flow into the frame opening, and easy for the raw materials to be filtered first by the filter belt. At the same time, the raw materials filtered by the filter belt will flow into the supporting inclined plate and be transported to the mixing box through the filter to realize the function of separating and processing the raw materials first. Optionally, in a possible embodiment, guide inclined plates are fixedly provided on both sides of the top of the supporting inclined plate, a frame opening is penetrated through the upper surface of the supporting inclined plate, the frame opening is located between the two guide inclined plates, the top of the separator body is rotatably connected with a rotating shaft, a plurality of baffles are sleeved on the rotating shaft, a plurality of the baffles are arranged side by side, and a mounting cavity is provided between each adjacent two baffles, a plurality of third separation filter plates are arranged in the plurality of mounting cavities, the third separation filter plates are distributed along the circumference of the rotating shaft axis, a reinforcing cross bar is provided between each adjacent two third separation filter plates, and a plurality of crushing rod bodies are provided on the reinforcing cross bar; It can be seen that in the above technical scheme, the rotation of the rotating shaft and the baffle can drive the third separation filter plate, the reinforcing cross bar and the crushing rod body to rotate. When the reinforcing cross bar and the crushing rod body rotate, the raw materials on the first separation filter plate are stirred, and the third separation filter plate separates and filters them again, so that the separated raw materials are accumulated on the first separation filter plate, resulting in poor separation treatment effect. At the same time, it is also easy to separate impurities on the third separation filter plate. At the same time, the first pulley is driven to rotate by the driving motor, and then the conveying roller and the filter belt are rotated to convey the raw materials remaining on the filter belt after separation, and convey them to the separator body to pass through the first separation filter plate for separation again. When the raw materials are separated in the separator body, the first pulley rotates and drives the second pulley to rotate through the belt, and then the rotating shaft and the baffle are rotated, which is easy for each structure to be linked to achieve diversity and continuity in raw material separation.

[0007] Optionally, in a possible embodiment, an extension plate body is provided on the side of the separator body away from the supporting inclined plate, an aeration pipe is provided at the bottom of the extension plate body, one end of the aeration pipe extends to one side of the mixing box and is connected with the mixing box, the aeration pipe is connected with the extension plate body, a pump is provided in the extension plate body, a driving motor is provided at the top of the support frame, a first pulley is provided at the output end of the driving motor, a second pulley is provided on one side of the first pulley, the second pulley is located at one end of the baffle, the first pulley is located at one end of the conveying roller, and the second pulley is connected to the first pulley by belt drive, and an upper baffle cover is provided on the top cover of the separator body, a sealing cover is hinged at one end of the upper baffle cover, and the arc sealing cover extends to one side of the top of the first separation filter plate.

[0008] It can be seen that in the above technical solution, the raw materials are transported to the mixing box after separation treatment by the first separation filter plate, the third separation filter plate, the filter belt and the filter, and the pure high-pressure gas flow is transported to the mixing box through the aeration pipe by the pump. Some gases, such as air, nitrogen, etc., can be dissolved through aeration to reduce the influence of these dissolved gases on the purity and stability of the product, and the pH value of the reaction system is easily adjusted, thereby accelerating the reaction process and ensuring the separation and mixing preparation effect.

[0009] Technical effects and advantages of the present invention: 1. The present invention adds raw materials to the supporting inclined plate and gathers them through the guide inclined plate, which makes it easy for the raw materials to flow into the frame opening and filter the raw materials through the filter belt first. At the same time, the raw materials filtered by the filter belt will flow into the supporting inclined plate and be transported to the mixing box through the filter to realize the function of separating and processing the raw materials first; 2. The present invention drives the first pulley to rotate through the driving motor, and then the conveying roller and the filter belt rotate, and the raw materials remaining on the filter belt after separation are conveyed, and are conveyed to the separator body to pass through the first separation filter plate for separation again. When the raw materials are separated in the separator body, the first pulley rotates and drives the second pulley to rotate through the belt, and then the rotating shaft and the baffle rotate, which facilitates the linkage of various structures and realizes the diversity and continuity of raw material separation; 3. The present invention can drive the third separation filter plate, the reinforcing cross bar and the crushing rod body to rotate when the rotating shaft and the baffle rotate. When the reinforcing cross bar and the crushing rod body rotate, the raw materials on the first separation filter plate are stirred, and the third separation filter plate separates and filters them again, so that the separated raw materials are accumulated on the first separation filter plate, resulting in poor separation treatment effect, and it is also easy to separate impurities on the third separation filter plate; 4. The present invention uses a pump to transport pure high-pressure air to the mixing box through an aeration pipe. Some gases, such as air and nitrogen, can be dissolved through aeration to reduce the influence of these dissolved gases on the purity and stability of the product, and it is easy to adjust the pH value of the reaction system, thereby accelerating the reaction process and ensuring the separation and mixing preparation effect; To sum up, through the corresponding coordinated use of various structures, the raw materials are added to the supporting inclined plate and gathered by the guide inclined plate, which makes it easy for the raw materials to flow into the frame mouth and be filtered first by the filter belt. At the same time, the raw materials after being filtered by the filter belt will flow into the supporting inclined plate and be transported to the mixing box through the filter to realize the function of first separating and processing the raw materials. The conveying roller and the filter belt rotate to transport the raw materials remaining on the filter belt after separation. The reinforcing cross bar and the crushing rod body stir the raw materials on the first separation filter plate when they rotate, and the third separation filter plate separates and filters them again, so that the separated raw materials are accumulated on the first separation filter plate, resulting in poor separation treatment effect. At the same time, it is also easy to separate impurities on the third separation filter plate, so as to realize diversity and continuity in raw material separation. At the same time, the pure high-pressure airflow is transported to the mixing box through the aeration pipe by the pump. Some gases can be dissolved by aeration to reduce the influence of these dissolved gases on the purity and stability of the product. It is easy to adjust the pH value of the reaction system, thereby accelerating the reaction process and ensuring the mixing preparation effect after separation. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] In order to more clearly illustrate the technical solutions in the present disclosure, the following briefly introduces the drawings required for use in some embodiments. Obviously, the drawings described below are only drawings of some embodiments of the present disclosure. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings. In addition, the drawings described below can be regarded as schematic diagrams, and are not intended to limit the actual size of the product involved in the embodiments of the present disclosure, the actual process of the method, the actual timing of the signal, etc.

[0011] Figure 1 It is the front view of the overall structure of the present invention.

[0012] Figure 2 It is a side view of the overall structure of the present invention.

[0013] Figure 3 It is a cross-sectional view of the overall structure of the present invention.

[0014] Figure 4 It is a stereoscopic diagram of the supporting inclined plate, the guide inclined plate, the separator body, the first separation filter plate, the mixing box, the aeration pipe and the extended plate body of the present invention.

[0015] Figure 5 It is a three-dimensional diagram of the conveying roller and the filter belt of the present invention.

[0016] Figure 6 It is a stereoscopic view of the separator body, the first separation filter plate, the mixing box and the second separation filter plate of the present invention.

[0017] Figure 7 It is a stereoscopic diagram of the supporting inclined plate, the guide inclined plate, the filter, the aeration pipe, the extension plate body and the pump of the present invention.

[0018] Figure 8 It is a schematic diagram of the rotating shaft, the baffle, the third separation filter plate reinforcing cross bar and the crushing rod body of the present invention when they are installed together.

[0019] Fig. 9 It is a schematic diagram of the third separation filter plate, the reinforcing cross bar and the crushing rod body of the present invention being installed on the baffle.

[0020] Fig.10 It is a stereoscopic diagram of the support frame, the second pulley, the belt, the first pulley and the upper baffle cover of the present invention.

[0021] The accompanying drawings are marked as follows: 1. support frame; 2. separator body; 3. first separation filter plate; 4. mixing box; 5. second separation filter plate; 6. supporting inclined plate; 7. guide inclined plate; 8. conveying roller; 9. filter belt; 10. filter; 11. rotating shaft; 12. baffle; 13. installation cavity; 14. third separation filter plate; 15. reinforcing cross bar; 16. crushing rod body; 17. extension plate body; 18. aeration pipe; 19. pump; 20. driving motor; 21. first pulley; 22. second pulley; 23. belt; 24. upper baffle cover. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] As attached Figure 1 - Fig.10The clindamycin hydrochloride separation device shown in the figure has a diversion separation component arranged on the support frame 1, and the raw material is added to the support inclined plate 6, and is gathered by the diversion inclined plate 7, so that the raw material is easy to flow into the frame mouth, and the raw material is easy to be filtered first by the filter belt 9. At the same time, the raw material after being filtered by the filter belt 9 will flow into the support inclined plate 6, and be transported to the mixing box 4 through the filter 10 to realize the function of first separating and processing the raw material. The conveying roller 8 and the filter belt 9 rotate to transport the raw material remaining on the filter belt 9 after separation, and the reinforcing cross bar 15 and the crushing rod body 16 rotate to stir the raw material on the first separation filter plate 3 , and the third separation filter plate 14 separates and filters it again, so that the separated raw materials are accumulated on the first separation filter plate 3, resulting in poor separation treatment effect. At the same time, it is also easy to separate impurities on the third separation filter plate 14, so as to achieve diversity and continuity in raw material separation. At the same time, the pure high-pressure airflow is transported to the mixing box 4 through the aeration pipe 18 by the pump 19. Some gases can be dissolved by aeration to reduce the influence of these dissolved gases on the purity and stability of the product. It is easy to adjust the pH value of the reaction system, thereby accelerating the reaction process and ensuring the mixing preparation effect after separation. The specific structure of the components is set as follows; The flow guide separation assembly includes a separator body 2 arranged on a support frame 1, a first separation filter plate 3 is clamped in the middle of the separator body 2, the vertical cross-section of the first separation filter plate 3 is set to be conical, a mixing box 4 is fixedly arranged at the bottom of the separator body 2, and a second separation filter plate 5 is clamped in the bottom of the inner cavity of the mixing box 4; A support inclined plate 6 for guiding materials is arranged on one side of the surface of the separator body 2, and a filter 10 is fixedly arranged on one side of the support inclined plate 6, and one end of the filter 10 is connected to the mixing box 4; Two conveying rollers 8 are rotatably connected inside the supporting inclined plate 6, and a filter belt 9 for filtering is transmission-connected to the conveying rollers 8; A guide inclined plate 7 is fixedly arranged on both sides of the top of the supporting inclined plate 6, a frame opening is penetrated through the upper surface of the supporting inclined plate 6, and the frame opening is located between the two guide inclined plates 7. The top of the separator body 2 is rotatably connected with a rotating shaft 11, and a plurality of baffles 12 are sleeved on the rotating shaft 11. The plurality of baffles 12 are arranged side by side, and an installation cavity 13 is arranged between each adjacent two baffles 12. A plurality of third separation filter plates 14 are arranged in the plurality of installation cavities 13. The third separation filter plates 14 are distributed along the circumference of the axis of the rotating shaft 11, and a reinforcing cross bar 15 is arranged between each adjacent two third separation filter plates 14, and a plurality of crushing rod bodies 16 are arranged on the reinforcing cross bar 15; An extension plate 17 is provided on the side of the separator body 2 away from the supporting inclined plate 6, and an aeration pipe 18 is provided at the bottom of the extension plate 17. One end of the aeration pipe 18 extends to one side of the mixing box 4 and is connected with the mixing box 4. The aeration pipe 18 is connected with the extension plate 17, and a pump 19 is provided in the extension plate 17. A driving motor 20 is provided on the top of the support frame 1, and a first pulley 21 is provided at the output end of the driving motor 20. A second pulley 22 is provided on one side of the first pulley 21, and the second pulley 22 is located at one end of the baffle 12. The first pulley 21 is located at one end of the conveying roller 8, and the second pulley 22 is connected to the first pulley 21 through a belt 23. The top cover of the separator body 2 is provided with an upper baffle cover 24, and a sealing cover is hinged at one end of the upper baffle cover 24, and the arc sealing cover extends to the top side of the first separation filter plate 3.

[0024] According to the above structure, when in use, the staff installs the device at the designated position. When separating the raw materials, the raw materials are added to the supporting inclined plate 6, and gathered by the guide inclined plate 7, so that the raw materials are easy to flow into the frame opening, and the raw materials are easy to be filtered first by the filter belt 9. At the same time, the raw materials filtered by the filter belt 9 will flow into the supporting inclined plate 6, and be transported to the mixing box 4 through the filter 10 to realize the function of separating the raw materials first. At the same time, the first pulley 21 is driven to rotate by the driving motor 20, and then the conveying roller 8 and the filter belt 9 are rotated, and the raw materials remaining on the filter belt 9 after separation are conveyed, and are conveyed to the separator body 2 to pass through the first separation filter plate 3 for separation again. When the raw materials are separated in the separator body 2, the first pulley 21 rotates and drives the second pulley 22 to rotate through the belt 23, and then the rotating shaft 11 and the baffle 12 are rotated, which facilitates the linkage of various structures to achieve diversity and continuity in raw material separation; When the rotating shaft 11 and the baffle plate 12 rotate, they can drive the third separation filter plate 14, the reinforcing cross bar 15 and the crushing rod body 16 to rotate. When the reinforcing cross bar 15 and the crushing rod body 16 rotate, the raw materials on the first separation filter plate 3 are stirred, and the third separation filter plate 14 separates and filters them again, so that the separated raw materials are accumulated on the first separation filter plate 3, resulting in a poor separation treatment effect, and it is also easy to separate impurities on the third separation filter plate 14; The raw materials are separated and processed by the first separation filter plate 3, the third separation filter plate 14, the filter belt 9 and the filter 10 and then transported to the mixing box 4. The pure high-pressure gas is transported to the mixing box 4 through the aeration pipe 18 by the pump 19. Some gases, such as air and nitrogen, can be dissolved by aeration to reduce the influence of these dissolved gases on the purity and stability of the product, and the pH value of the reaction system is easily adjusted, thereby accelerating the reaction process and ensuring the separation and mixing preparation effect.

[0025] Different from the prior art, the present application discloses a clindamycin hydrochloride separation device, wherein the raw materials are added to the support inclined plate 6, and gathered by the guide inclined plate 7, so that the raw materials are easy to flow into the frame mouth, and the raw materials are easy to be filtered first by the filter belt 9. At the same time, the raw materials after being filtered by the filter belt 9 will flow into the support inclined plate 6, and be transported to the mixing box 4 through the filter 10 to realize the function of first separating and processing the raw materials. The conveying roller 8 and the filter belt 9 rotate to transport the raw materials remaining on the filter belt 9 after separation, and the reinforcing cross bar 15 and the crushing rod body 16 rotate to strengthen the first separation filter plate 3. The raw materials are stirred, and the third separation filter plate 14 separates and filters them again, so that the separated raw materials are accumulated on the first separation filter plate 3, resulting in poor separation treatment effect. At the same time, it is also easy to separate impurities on the third separation filter plate 14, so as to achieve diversity and continuity in raw material separation. At the same time, the pure high-pressure air flow is transported to the mixing box 4 through the aeration pipe 18 by the pump 19. Some gases can be dissolved by aeration to reduce the influence of these dissolved gases on the purity and stability of the product. It is easy to adjust the pH value of the reaction system, thereby accelerating the reaction process and ensuring the mixing preparation effect after separation.

[0026] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A clindamycin hydrochloride separation device, comprising a support frame (1), characterized in that: The support frame (1) is provided with a flow diversion and separation component; The flow guide separation assembly comprises a separator body (2) arranged on a support frame (1), a first separation filter plate (3) being clamped in the middle of the separator body (2), a mixing box (4) being fixedly arranged at the bottom of the separator body (2), and a second separation filter plate (5) being clamped in the bottom of the inner cavity of the mixing box (4); A supporting inclined plate (6) is provided on one side of the separator body (2), and a filter (10) is fixedly provided on one side of the supporting inclined plate (6); Two conveying rollers (8) are rotatably connected inside the supporting inclined plate (6), and a filter belt (9) for filtering is transmission-connected to the conveying rollers (8).

2. A clindamycin hydrochloride separation device according to claim 1, characterized in that: Guide inclined plates (7) are fixedly arranged on both sides of the top of the supporting inclined plate (6), and a frame opening is opened through the upper surface of the supporting inclined plate (6), and the frame opening is located between the two guide inclined plates (7).

3. A clindamycin hydrochloride separation device according to claim 1, characterized in that: The top of the separator body (2) is rotatably connected to a rotating shaft (11), and a plurality of baffles (12) are sleeved on the rotating shaft (11).

4. A clindamycin hydrochloride separation device according to claim 3, characterized in that: The plurality of baffles (12) are arranged side by side, and an installation cavity (13) is provided between each two adjacent baffles (12), and a plurality of third separation filter plates (14) are provided in the plurality of installation cavities (13).

5. A clindamycin hydrochloride separation device according to claim 4, characterized in that: The third separation filter plates (14) are distributed along the circumference of the axis of the rotating shaft (11), and a reinforcing cross bar (15) is provided between each two adjacent third separation filter plates (14), and a plurality of crushing rod bodies (16) are provided on the reinforcing cross bar (15).

6. A clindamycin hydrochloride separation device according to claim 1, characterized in that: An extended plate body (17) is provided on a side of the separator body (2) away from the supporting inclined plate (6), and an aeration pipe (18) is provided at the bottom of the extended plate body (17).

7. A clindamycin hydrochloride separation device according to claim 6, characterized in that: A pump (19) is arranged in the extended plate body (17).

8. A clindamycin hydrochloride separation device according to claim 3, characterized in that: A driving motor (20) is arranged on the top of the support frame (1), a first belt pulley (21) is arranged at the output end of the driving motor (20), and a second belt pulley (22) is arranged on one side of the first belt pulley (21).

9. A clindamycin hydrochloride separation device according to claim 8, characterized in that: The second belt pulley (22) is located at one end of the baffle (12), the first belt pulley (21) is located at one end of the conveying roller (8), and the second belt pulley (22) is connected to the first belt pulley (21) via a belt (23).

10. A clindamycin hydrochloride separation device according to claim 1, characterized in that: The top cover of the separator body (2) is provided with an upper blocking cover (24), one end of the upper blocking cover (24) is hingedly connected with a sealing cover, and the arc sealing cover extends to one side of the top of the first separation filter plate (3).

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