Displacement device of immunity analyzer

Abstract

Belonging to the technical field of biological detection, the invention discloses an immunoassay analyzer displacement device, which comprises a reaction disc shell, a reaction disc rotatably connected to the reaction disc shell, and a driving assembly for driving the reaction disc to rotate relative to the reaction disc shell, and also comprises: a device base detachably connected with the reaction disc shell; the pushing mechanism is mounted on the device base and is used for pushing the reaction cups to the placement mechanism mounted on the reaction disc; the feeding mechanism is mounted on the device base and is used for transferring the reaction cup to the pushing mechanism for transferring treatment; the placement mechanism is mounted on the reaction disc and is used for carrying out placement treatment on the reaction cups; the loading position and the unloading position of the reaction cup are integrated, and when a new reaction cup is loaded, unloading of an old reaction cup can be completed conveniently.

Description

Technical Field

[0001] The invention belongs to the technical field of biological detection, and in particular relates to a position changing device of an immunoassay analyzer. Background Art

[0002] At present, in vitro diagnosis is one of the most commonly used diagnostic methods in the medical field. According to the detection principle or detection method, in vitro diagnosis is mainly divided into biochemical diagnosis, immunological diagnosis, molecular diagnosis, microbiological diagnosis, urine diagnosis, coagulation diagnosis, blood and flow cytometric diagnosis, etc. Among them, biochemical and immunological are the main methods of in vitro diagnosis in my country. These diagnostic methods all use fully automatic or semi-automatic instruments to add samples, analyze and give diagnostic reports.

[0003] During the test, a reaction cup is needed to hold the reaction reagent and body fluid sample and mix them. After a period of reaction in a heated and heat-insulating environment, the reaction cup is transported to the detection position for photoelectric conversion detection.

[0004] Immunoassay analyzers often use disposable cuvettes. As test consumables, cuvettes need to be replenished and removed (loaded and unloaded). Usually, cuvettes are placed in cuvette receiving grooves distributed along the circumference of the reaction disk. Due to the ratio of the diameter of the cuvette to the reaction disk, the number of cuvettes that can be accommodated in a single row of reaction disks is limited. To increase the number of cuvettes, the diameter of the reaction disk must also be made larger, which is not conducive to the miniaturization of the equipment.

[0005] In addition, a robot or other mechanism is required to automatically load and unload the reaction cup, so it is necessary to design a reaction cup displacement device with a compact structure, fast action and low cost to realize automatic loading and unloading of the reaction cup.

[0006] Furthermore, high-speed immunoassay analyzers require an efficient testing rhythm, but the reaction disk has large inertia, and each start and stop will affect the test speed. The reaction cup loading position and discarding position of common equipment are arranged separately, which not only makes the mechanism repetitive and complicated, increasing the size and cost of the equipment, but also reduces operating efficiency. Summary of the invention

[0007] In view of the deficiencies in the prior art, the present invention provides an immunoassay analyzer displacement device to solve the above problems.

[0008] To achieve the above objectives, the present invention is implemented through the following technical solutions: an immunoassay analyzer displacement device, comprising a reaction disk housing, a reaction disk rotatably connected to the reaction disk housing, and a driving assembly for driving the reaction disk to rotate relative to the reaction disk housing, and further comprising: The device base is detachably connected to the reaction disk housing; A pushing mechanism, installed on the device base, used to push the reaction cup to the placement mechanism installed on the reaction disk; A feeding mechanism, installed on the base of the device, is used to transfer the reaction cup to the pushing mechanism for transfer processing; A placement mechanism, installed on the reaction tray, for placing the reaction cup; Wherein, the placement mechanism includes a strip groove and a circular groove, the strip groove passes through the circular groove, and the strip groove and the circular groove are both opened on the reaction disk; The pushing mechanism includes a stepper motor, a spur gear and a rack. The stepper motor is detachably connected to the device base. The spur gear fixedly connected to the output shaft of the stepper motor is meshed with the rack. The rack slides with a guide rail detachably mounted on the device base. The end of the rack close to the reaction disk housing is detachably connected to a mounting seat. A push-pull electromagnet is mounted on the mounting seat. A photoelectric switch is detachably mounted on one side of the device base. A chopper is arranged above the rack and is detachably connected to the device base.

[0009] On the basis of the above technical solution, the present invention also provides the following optional technical solution: Further technical solution: Several groups of the strip grooves and circular grooves are evenly distributed in a ring shape in one-to-one correspondence, and a discard tube for cooperating with the circular grooves to recycle the reaction cups is fixedly connected to the reaction disk shell.

[0010] Further technical solution: The feeding mechanism includes a ramp, which is detachably connected to the side of the device base. The ramp and the device base are both provided with slide rails for the reaction cup to slide. The cross-section of the slide rail is T-shaped and the two slide rails are interconnected.

[0011] Further technical solution: the reaction disk shell is provided with a feed port for cooperating with a slide rail to guide the reaction cup into the strip-shaped slot, and the slide rail provided on the ramp is sloped.

[0012] Further technical solutions also include an adjustment and evaluation system for regulating the pushing mechanism and the push-pull electromagnet and evaluating the operating status of the device.

[0013] Further technical solution: The adjustment and evaluation system includes: The speed detection unit is used to detect the movement speed of the push-pull electromagnet and is a speed sensor; The displacement detection unit is used to detect the displacement distance of the movable iron core column in the push-pull electromagnet and is a distance sensor; A storage module, used to store the data detected by the speed detection unit and the displacement detection unit and to establish a data set; A threshold module is used to retrieve the movement speed information of the push-pull electromagnet at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet at the current moment in the storage module, compare the two with the preset threshold, and judge whether at least one of the speed information and the displacement information exceeds the corresponding preset threshold. If at least one of them exceeds the corresponding preset threshold, the judgment information for controlling the stepping motor or the push-pull electromagnet is formed; An analysis module is used to retrieve the movement speed information of the push-pull electromagnet at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet at the current moment in the storage module to form a prediction value, and compare the prediction value with a preset prediction threshold to form judgment information for controlling the stepper motor or the push-pull electromagnet, and at the same time associate the prediction value formed by the speed information and the displacement information to form an adjustment evaluation coefficient, and compare the formed adjustment evaluation coefficient with the preset adjustment evaluation threshold to form judgment information for controlling the stepper motor or the push-pull electromagnet; A control module, used for receiving the judgment information and controlling the stepper motor and the push-pull electromagnet according to the judgment information; The warning module performs warning processing according to the judgment information received by the control module.

[0014] Further technical solution: The specific processing method of the analysis module is: S1. Obtain the current speed information and displacement information through the data set of the storage module, recorded as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ; S2. Predict the speed information, speed information and displacement at the next moment by linear regression, and obtain the predicted values ​​respectively. V i and S i , and compare it with the corresponding velocity threshold and displacement threshold. If the predicted value V i and S i If any one of the speed threshold and the temperature threshold is greater than the corresponding one, the judgment information for controlling the stepper motor or the push-pull electromagnet is formed; S3. Based on the predicted value, tThe predicted value formed by the speed information at the moment (that is, the next moment) and the displacement information is associated to form an adjustment coefficient, and the expression of the adjustment coefficient is: ; in, represents the adjustment coefficient, represents the speed prediction value, represents the displacement prediction value, Indicates the influence factor of the reaction cup material. When the reaction cup material is polystyrene, , when the reaction cup is made of polycarbonate, , Indicates the number of items; S4, comparing the obtained adjustment evaluation coefficient with a preset adjustment evaluation coefficient threshold to form a comparison result. If the adjustment evaluation coefficient is greater than the preset threshold, judgment information for controlling the stepping motor and the push-pull electromagnet is formed; S5. Transmit the above-formed judgment information to the control module for related module control.

[0015] The present invention provides an immunoassay analyzer displacement device, which has the following beneficial effects compared with the prior art: The present invention integrates the reaction cup loading position and the unloading position into one place. When a new reaction cup is loaded, the old reaction cup is unloaded and enters the waste recovery pipeline for recovery, which saves the start and stop time of the reaction disk and the overall manufacturing cost, and makes the structure more compact. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention.

[0017] Figure 2 It is a structural schematic diagram of the pushing mechanism of the present invention.

[0018] Figure 3 It is a structural schematic diagram of the placement mechanism of the present invention.

[0019] Figure 4 It is a partial structural schematic diagram of the placement mechanism of the present invention.

[0020] Figure 5 It is a structural schematic diagram of the feeding mechanism of the present invention.

[0021] Figure 6 It is a structural schematic diagram of the feeding mechanism of the present invention from another angle.

[0022] Notes on the figure numbers: 1. Reaction disk housing; 2. Reaction disk; 3. Device base; 4. Pushing mechanism; 401. Stepping motor; 402. Flat gear; 403. Rack; 404. Chopper; 405. Push-pull electromagnet; 406. Photoelectric switch; 407. Guide rail; 5. Feeding mechanism; 501. Ramp; 502. Slide rail; 6. Placement mechanism; 601. Strip slot; 602. Round slot; 603. Discard tube; 7. Reaction cup. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0024] The specific implementation of the present invention is described in detail below in conjunction with specific embodiments.

[0025] See also Figures 1 to 6 , provided in one embodiment of the present invention, is an immunoassay analyzer displacement device, comprising a reaction disk housing 1, a reaction disk 2 rotatably connected to the reaction disk housing 1, and a driving assembly (not shown in the figure, which is a prior art and will not be described in detail) for driving the reaction disk 2 to rotate relative to the reaction disk housing 1, and further comprising: The device base 3 is detachably connected to the reaction disk housing 1; A pushing mechanism 4, mounted on the device base 3, for pushing the reaction cup 7 to the placement mechanism 6 mounted on the reaction disk 2; A feeding mechanism 5 is installed on the device base 3 and is used to transfer the reaction cup 7 to the pushing mechanism 4 for transfer processing; The placement mechanism 6 is installed on the reaction disk 2 and is used to place the reaction cup 7; The placement mechanism 6 includes a strip groove 601 and a circular groove 602, the strip groove 601 penetrates the circular groove 602, and the strip groove 601 and the circular groove 602 are both provided on the reaction disk 2, one by one correspondingly and a plurality of groups of the strip grooves 601 and the circular grooves 602 are evenly distributed on the reaction disk 2 in a ring shape, and a discard tube 603 for cooperating with the circular groove 602 to recycle the reaction cup 7 is fixedly connected to the reaction disk housing 1; Wherein, the pushing mechanism 4 includes a stepping motor 401, a flat gear 402 and a rack 403, the stepping motor 401 is detachably connected to the device base 3, the flat gear 402 fixedly connected to the output shaft of the stepping motor 401 is meshed with the rack 403, the rack 403 is slidably matched with a guide rail 407 detachably mounted on the device base 3, the end of the rack 403 close to the reaction disk housing 1 is detachably connected to a mounting seat (not shown in the figure), a push-pull electromagnet 405 is mounted on the mounting seat, a photoelectric switch 406 is detachably mounted on one side of the device base 3, a chopper 404 is arranged above the rack 403, and the chopper 404 is detachably connected to the device base 3; Among them, the feeding mechanism 5 includes a ramp 501, which is detachably connected to the side of the device base 3. The ramp 501 and the device base 3 are both provided with slide rails 502 for the reaction cup 7 to slide. The cross-section of the slide rail 502 is T-shaped and the two slide rails 502 are interconnected. The reaction disk housing 1 is provided with a feed port (not marked in the figure) for cooperating with the slide rail 502 to guide the reaction cup 7 into the strip groove 601. The slide rail 502 opened on the ramp 501 is sloped.

[0026] In the embodiment of the present invention, the external cup supply mechanism automatically supplies the reaction cup on the slide rail 502, and the reaction cup 7 slides down to the bottom of the push-pull electromagnet 405 under the action of its own gravity. The push-pull electromagnet 405 is started, and the push-pull electromagnet 405 extends the movable iron core column into one or two reaction cups 7 accordingly. At this time, the stepper motor 401 is started to drive the flat gear 402 to perform a rotational movement in the vertical direction. The flat gear 402 drives the mounting seat to perform a linear movement in the horizontal direction by pushing the rack 403 meshing with it. The mounting seat synchronously drives the push-pull electromagnet 405 to perform a linear movement, and the push-pull electromagnet 405 extends one or two reaction cups 7. The reaction cup 7 is pushed into the strip slot 601. If there is a reaction cup 7 in the corresponding strip slot 601, the reaction cup 7 will be pushed into the circular slot 602 by the newly entered reaction cup 7 and fall into the discard tube 603 for recovery through the guidance of the circular slot 602, thereby realizing rapid loading and disassembly of the reaction cup 7 and the loading and disassembly can be completed synchronously. The push-pull electromagnet 405 can constitute a toggle mechanism, which can be quickly extended or retracted, replacing the lifting mechanism, and the compound action is more diversified. The reaction disk with a multi-ring arrangement increases the capacity of the reaction disk, and the reaction cup loading and unloading positions are combined, the structure is compact, and the action rhythm is more efficient.

[0027] As an embodiment of the present invention, it also includes an adjustment and evaluation system for adjusting the pushing mechanism 4 and the push-pull electromagnet 405 and evaluating the operating state of the device, and the adjustment and evaluation system includes: The speed detection unit is used to detect the movement speed of the push-pull electromagnet 405 and is a speed sensor; The displacement detection unit is used to detect the displacement distance of the movable iron core column in the push-pull electromagnet 405, and is a distance sensor; A storage module, used to store the data detected by the speed detection unit and the displacement detection unit and to establish a data set; A threshold module is used to retrieve the movement speed information of the push-pull electromagnet 405 at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet 405 at the current moment in the storage module, compare the two with the preset threshold, and determine whether at least one of the speed information and the displacement information exceeds the corresponding preset threshold. If at least one of them exceeds the corresponding preset threshold, the determination information for controlling the stepping motor 401 or the push-pull electromagnet 405 is formed; An analysis module is used to retrieve the movement speed information of the push-pull electromagnet 405 at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet 405 at the current moment in the storage module to form a prediction value, and compare the prediction value with a preset prediction threshold to form judgment information for controlling the stepper motor 401 or the push-pull electromagnet 405, and at the same time associate the prediction value formed by the speed information and the displacement information to form an adjustment evaluation coefficient, and compare the formed adjustment evaluation coefficient with the preset adjustment evaluation threshold to form judgment information for controlling the stepper motor 401 or the push-pull electromagnet 405; A control module, used for receiving the judgment information and controlling the stepping motor 401 and the push-pull electromagnet 405 according to the judgment information; The warning module performs warning processing according to the judgment information received by the control module; The specific processing method of the analysis module is: S1. Obtain the current speed information and displacement information through the data set of the storage module, recorded as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ; S2. Predict the speed information, speed information and displacement at the next moment by linear regression, and obtain the predicted values ​​respectively. V i and S i , and compare it with the corresponding velocity threshold and displacement threshold. If the predicted valueV i and S i If any one of the speed threshold and the temperature threshold is greater than the corresponding one, the judgment information for controlling the stepping motor 401 or the push-pull electromagnet 405 is formed; S3. Based on the predicted value, t The predicted value formed by the speed information at the moment (that is, the next moment) and the displacement information is associated to form an adjustment coefficient, and the expression of the adjustment coefficient is: ; in, represents the adjustment coefficient, represents the speed prediction value, represents the displacement prediction value, It represents the influence factor of the material of the reaction cup 7. When the material of the reaction cup 7 is polystyrene, When the reaction cup 7 is made of polycarbonate, , Indicates the number of items; S4, comparing the obtained adjustment evaluation coefficient with the preset adjustment evaluation coefficient threshold to form a comparison result. If the adjustment evaluation coefficient is greater than the preset threshold, judgment information for controlling the stepping motor 401 and the push-pull electromagnet 405 is formed; S5. Transmit the above-formed judgment information to the control module for related module control.

[0028] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0029] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A displacement device for an immunoassay analyzer, comprising a reaction disk housing (1), a reaction disk (2) rotatably connected to the reaction disk housing (1), and a driving assembly for driving the reaction disk (2) to rotate relative to the reaction disk housing (1), characterized in that: Also includes: A device base (3) is detachably connected to the reaction disk housing (1); A pushing mechanism (4) is mounted on the device base (3) and is used to push the reaction cup (7) onto the placement mechanism (6) mounted on the reaction disk (2); A feeding mechanism (5) is installed on the device base (3) and is used to transfer the reaction cup (7) to the pushing mechanism (4) for transfer processing; A placement mechanism (6) is installed on the reaction disk (2) and is used to place the reaction cup (7); The placement mechanism (6) comprises a strip-shaped slot (601) and a circular slot (602), the strip-shaped slot (601) passes through the circular slot (602), and both the strip-shaped slot (601) and the circular slot (602) are arranged on the reaction disk (2); The pushing mechanism (4) comprises a stepping motor (401), a spur gear (402) and a rack (403); the stepping motor (401) is detachably connected to the device base (3); the spur gear (402) fixedly connected to the output shaft of the stepping motor (401) meshes with the rack (403); the rack (403) is slidably matched with a guide rail (407) detachably mounted on the device base (3); an end of the rack (403) close to the reaction disk housing (1) is detachably connected to a mounting seat; a push-pull electromagnet (405) is mounted on the mounting seat; a photoelectric switch (406) is detachably mounted on one side of the device base (3); a chopper (404) is arranged above the rack (403) and the chopper (404) is detachably connected to the device base (3).

2. The immunoassay analyzer displacement device according to claim 1, characterized in that: The strip-shaped slots (601) and circular slots (602) are arranged in a one-to-one correspondence and are evenly distributed in a ring shape. A discard tube (603) for cooperating with the circular slots (602) to recover the reaction cup (7) is fixedly connected to the reaction disk housing (1).

3. The immunoassay analyzer displacement device according to claim 2, characterized in that: The feeding mechanism (5) comprises a ramp (501), the ramp (501) being detachably connected to the side of the device base (3), the ramp (501) and the device base (3) both being provided with a slide rail (502) for the reaction cup (7) to slide, the cross section of the slide rail (502) being T-shaped and the two slide rails (502) being interconnected.

4. The immunoassay analyzer displacement device according to claim 3, characterized in that: The reaction disk housing (1) is provided with a feed port for cooperating with the slide rail (502) to guide the reaction cup (7) into the strip-shaped slot (601), and the slide rail (502) provided on the ramp platform (501) is in a slope shape.

5. The immunoassay analyzer displacement device according to claim 1, characterized in that: It also includes an adjustment and evaluation system for adjusting the pushing mechanism (4) and the push-pull electromagnet (405) and evaluating the operating status of the device.

6. The immunoassay analyzer displacement device according to claim 5, characterized in that: The adjustment and evaluation system comprises: A speed detection unit, used for detecting the movement speed of the push-pull electromagnet (405), which is a speed sensor; A displacement detection unit, used for detecting the displacement distance of a movable iron core column in the push-pull electromagnet (405), which is a distance sensor; A storage module, used to store the data detected by the speed detection unit and the displacement detection unit and to establish a data set; a threshold module, used to retrieve the movement speed information of the push-pull electromagnet (405) at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet (405) at the current moment from the storage module, compare the two with a preset threshold, and judge whether at least one of the speed information and the displacement information exceeds the corresponding preset threshold; if at least one of them exceeds the corresponding preset threshold, then form judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405); and An analysis module, used for retrieving the movement speed information of the push-pull electromagnet (405) at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet (405) at the current moment from the storage module to form a prediction value, and comparing the prediction value with a preset prediction threshold value to form judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405), and at the same time associating the prediction value formed by the speed information and the displacement information to form an adjustment evaluation coefficient, and comparing the formed adjustment evaluation coefficient with the preset adjustment evaluation threshold value to form judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405); A control module, used for receiving the judgment information and controlling the stepping motor (401) and the push-pull electromagnet (405) according to the judgment information; The warning module performs warning processing according to the judgment information received by the control module.

7. The immunoassay analyzer displacement device according to claim 6, characterized in that: The specific processing method of the analysis module is: S1. Obtain the current speed information and displacement information through the data set of the storage module, recorded as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ; S2. Predict the speed information, speed information and displacement at the next moment by linear regression, and obtain the predicted values ​​respectively. V i and S i , and compare it with the corresponding velocity threshold and displacement threshold. If the predicted value V i and S i If any one of the speed threshold and the temperature threshold is greater than the corresponding one, judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405) is formed; S3. Based on the predicted value, t The predicted value formed by the speed information and the displacement information at the moment is associated to form an adjustment coefficient, and the expression of the adjustment coefficient is: ； in, represents the adjustment coefficient, represents the speed prediction value, represents the displacement prediction value, represents the influence factor of the material of the reaction cup (7). When the material of the reaction cup (7) is polystyrene, (1), when the material of the reaction cup (7) is polycarbonate, , Indicates the number of items; S4, comparing the obtained adjustment evaluation coefficient with a preset adjustment evaluation coefficient threshold to form a comparison result, and if the adjustment evaluation coefficient is greater than the preset threshold, forming judgment information for controlling the stepping motor (401) and the push-pull electromagnet (405); S5. Transmit the above-formed judgment information to the control module for related module control.

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