Universal metabolism cage for rats and guinea pigs and testing method thereof

Abstract

The invention discloses a universal metabolism cage for rats and guinea pigs and a testing method thereof, and belongs to the technical field of animal experiment equipment. The rat metabolism cage overcomes the defect that in the prior art, urine and excrement in a traditional rat metabolism cage cannot be separated out and can only be collected through the same collection barrel for collecting the urine and the excrement, and then the accuracy of experimental data is affected. A main body structure of the device comprises a frame, a separating and collecting mechanism used for separating and conveying excrement and urine is installed on the frame, a moving mechanism used for limiting an activity area of experimental animal rats and providing an energy obtaining space is arranged above the separating and collecting mechanism, and a feeding mechanism and a water drinking mechanism are arranged on the front side of the moving mechanism. A storage mechanism for storing excrement and urine is arranged below the separation and collection mechanism. The device is mainly used for metabolism separation experiments of mice.

Description

Technical Field

[0001] The invention belongs to the technical field of animal experimental equipment, and in particular relates to a universal metabolic cage for rats and guinea pigs and a testing method thereof. Background Art

[0002] The animal mouse metabolic cage is an animal experimental equipment used in the study of pharmacology, toxicology, nutrition, obesity and metabolic diseases. It is used to detect the food intake, water intake, activity status, urine and feces collection of the test animals in their natural activity state, providing researchers with efficient, accurate and reliable experimental data.

[0003] At present, although the rat metabolic cages in the existing technology can separate urine and feces, the parameters such as the space size of the metabolic cages, feeders, waterers and excrement separators will affect the living habits of the experimental animals. The excrement of the experimental animals obtained is greatly different from the excrement results under natural habits, the reliability of the experimental data results is poor, and when conducting metabolic separation experiments on different rats, there are many types of equipment and poor flexibility.

[0004] For example, the Chinese utility model patent with authorization announcement number CN 205865514 U discloses a rat metabolic cage, the Chinese invention patent with application publication number CN118511825A discloses an experimental rat urine collector, and the Chinese utility model patent with authorization announcement number CN205357593U discloses a simple rat metabolic cage for experiments. The above patents have the disadvantages that urine and feces cannot be separated and can only be collected in the same collection bucket for urine and feces, which affects the accuracy of experimental data. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a universal metabolic cage for rats and guinea pigs and a testing method thereof.

[0006] In order to achieve the above object, the present invention is implemented by adopting the following technical solutions:

[0007] A universal metabolic cage for rats and guinea pigs comprises a frame, on which a separation and collection mechanism for separating and transporting feces and urine is installed, above which an activity mechanism for limiting the activity area of ​​experimental animals and providing energy acquisition space is arranged, a feeding mechanism and a drinking mechanism are arranged at the front side of the activity mechanism, and below which a storage mechanism for storing feces and urine is arranged.

[0008] Preferably, the frame comprises a support plate, and a convex ring and a notch for mounting the separation and collection mechanism are arranged on the circular notch of the support plate.

[0009] Preferably, the separation and collection mechanism includes a lower chamber with an open upper end, a collecting funnel arranged inside the lower chamber, a separation cone and a urine collecting ring arranged inside the collecting funnel, the lower chamber is mounted on the circular notch of the support plate and is positioned by a convex ring; the upper end of the separation cone is mounted on the notch of the support plate through an arc-shaped bracket, and the urine collecting ring is mounted on the bottom of the collecting funnel.

[0010] Preferably, the separation cone opens downward, and has four arch structures at the bottom, with guide points for guiding urine to flow downward in streams formed between two adjacent arch structures, and the taper α of the separation cone ranges from 85 to 90°.

[0011] Preferably, the storage mechanism includes a feces storage tube and a urine storage tube movably installed at the bottom of the lower chamber, the urine collecting ring is inclined, a diversion port is opened at the lowest end, and the diversion direction of the lowest end of the urine collecting ring is consistent with that of the urine storage tube; the feces receiving port of the feces storage tube is installed in the conical port at the lower end of the collecting funnel.

[0012] Preferably, the movable mechanism comprises an movable chamber, a bottom net and a top cover, the movable chamber is coaxially movably installed above the separation and collection mechanism, the bottom net is arranged between the movable chamber and the separation and collection mechanism, and the top cover is detachably installed above the movable chamber.

[0013] Preferably, the feeding mechanism comprises a silo and a feeding chamber with an open rear end, the silo is slidably connected to both sides of the bottom end of the feeding chamber, and a partition is provided in the silo, and the silo is divided into an outer silo for placing feed and an empty inner silo by the partition.

[0014] Preferably, the drinking mechanism comprises a drinking bottle, a drinking bracket and a reflux pipe, the drinking bracket is installed outside the activity room, the drinking bottle opening is tilted downwardly and arranged above the drinking bracket, and the reflux pipe is movably installed below the drinking bracket.

[0015] A test method, using the universal metabolic cage for rats and guinea pigs as described in any one of the above, comprises the following steps:

[0016] S1: Use tweezers to drop 50 pieces of mouse feces naturally from about 1 cm above the bottom net, and observe the number and weight of feces in the feces storage tube;

[0017] S2: Use a syringe to extract mouse urine, and let it drip naturally from about 1 cm above the bottom net to simulate normal mouse defecation, and observe the urine weight in the urine storage tube;

[0018] S3: Repeat the test 20 times and calculate the average value. The calculation formula is:

[0019] H=m / M

[0020] H n =(m1+m2+m3+…+m n) / (M1+M2+M3+…+M n )

[0021] Among them, H represents the recovery accuracy; m represents the weight after the experiment; M represents the weight before the experiment; H n Represents the average recovery precision.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. Since the urine and feces of rats or guinea pigs fall from the bottom net, if there is no separation cone, the urine and feces of rats or guinea pigs will enter the feces storage tube. Since the separation cone is set, after the urine of rats or guinea pigs passes through the separation cone, the urine will drip onto the separation cone. Since the urine has a certain viscosity, the urine will flow down along the wall of the separation cone, which has a certain deceleration effect. It will continue to flow down and will flow to the inner wall of the collecting funnel, close to the inner wall of the collecting funnel, and then enter the urine collecting ring along the inclined cone at the lower end of the collecting funnel. Since the urine collecting ring is inclined and a diversion port is opened at the lowest end, the urine will finally flow into the urine storage tube; if it is the normal feces of rats or guinea pigs, since the feces are solid, when passing through the separation cone, the speed of the urine is reduced and then falls into the feces storage tube, thereby achieving the separation of urine and feces;

[0024] 2. Parallel polished metal wires are arranged at the lower end and the front end of the feeding room, and the lower end wires are provided with square holes. Slide grooves are arranged on both sides of the bottom end of the feeding room, and symmetrical limiting grooves are arranged at the front end of the slide grooves. The feed bin is slidably installed in the slide groove of the feeding room, and a limiting protrusion that can be fixed with the limiting groove of the feeding room is arranged at the end of the feed bin. The limiting protrusion is matched with the limiting groove on the feeding room. If there is no limiting protrusion structure, rats or guinea pigs may slip out of the feeding room and the feed bin when obtaining feed;

[0025] The feed bin is divided into two bins by a partition, an inner bin and an outer bin. The outer bin is used to store normal feed for rats or guinea pigs, but the inner bin is empty. The reason is that rats or guinea pigs will drag the objects when eating, and the experiment requires that the objects cannot be dragged into the activity room. Therefore, the inner bin needs to be empty. When the rats or guinea pigs drag the objects, they will fall into the inner bin for recycling. Finally, the result of the experiment is to calculate the grams of feed eaten by the rats or guinea pigs. Therefore, the grams of food eaten by the rats or guinea pigs can be accurately calculated by combining the grams of food eaten and the grams of food dragged, thereby ensuring the accuracy of the experimental results.

[0026] 3. When the drinking bottle is filled with water, the drinking bottle is placed on the drinking stand with the water outlet facing downward. Water will flow out only when the rat or guinea pig touches the bottle mouth of the drinking bottle. When no object touches the bottle mouth, the water will not flow out. If the rat or guinea pig does not have drinking water, but the bottle mouth leaks due to vibration in the cage, the water will flow back to the reflux pipe through the inclined slope at the lower end of the drinking stand. A small funnel is set in the reflux pipe to prevent water evaporation. The whole process can accurately calculate the amount of water drunk by the rat or guinea pig, providing accurate data for subsequent experimental results.

[0027] 4. Whether it is the process of adding water or adding materials, rats or guinea pigs must not be disturbed, otherwise it will lead to the failure of the entire experiment. Therefore, the present invention can conveniently add water and materials without disturbing rats or guinea pigs through the feeding mechanism and the drinking water mechanism, avoiding large vibration and noise generated by the equipment, and ensuring the accuracy of the experiment;

[0028] In summary, the present invention can effectively reduce the stress response of experimental animals, obtain the metabolic laws under normal living conditions, improve the experimental living environment of the test animals so that they can maintain their natural living habits as much as possible, obtain experimental data on the pathological evolution process under normal living conditions, improve the accuracy of scientific experiments, and at the same time solve the problem that the metabolic equipment for rats and guinea pigs in the prior art is not universal. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a structural schematic diagram of the present invention;

[0030] Figure 2 It is a schematic diagram of the internal structure of the present invention;

[0031] Figure 3 It is a structural schematic diagram of the support plate in the present invention;

[0032] Figure 4 It is a schematic diagram of the structure of the separation cone in the present invention;

[0033] Figure 5 Schematic diagram of the taper of the separation cone in the present invention;

[0034] Figure 6 It is a structural schematic diagram of the feeding mechanism in the present invention;

[0035] Figure 7 It is a structural schematic diagram of the drinking water mechanism in the present invention;

[0036] Figure 8 It is a schematic diagram of the structure of the urine collecting ring in the present invention;

[0037] Fig. 9 It is a schematic diagram of the installation structure of the urine collecting ring in the present invention.

[0038] In the figure: 1, frame; 11, support frame; 12, slide rail; 13, support plate; 14, notch; 15, convex ring;

[0039] 2. Separation and collection mechanism; 21. Lower chamber; 22. Collection funnel; 23. Separation cone; 24. Urine collection ring; 231. Arc-shaped bracket;

[0040] 3. Activity mechanism; 31. Activity room; 32. Bottom net; 33. Top cover; 321. Handle;

[0041] 4. Feeding mechanism; 41. Feeding room; 42. Feed bin; 43. Position limiting groove; 44. Position limiting protrusion; 45. Partition plate;

[0042] 5. Drinking water mechanism; 51. Drinking water bottle; 52. Drinking water support; 53. Reflux pipe;

[0043] 6. Storage mechanism; 61. Feces storage tube; 62. Urine storage tube. DETAILED DESCRIPTION

[0044] The present invention will be further described below through specific embodiments in conjunction with the accompanying drawings.

[0045] Embodiment 1:

[0046] like Figure 1 As shown, a universal metabolic cage for rats and guinea pigs comprises a frame 1, on which a separation and collection mechanism 2 for separating and transporting feces and urine is installed, above the separation and collection mechanism 2 is an activity mechanism 3 for limiting the activity area of ​​experimental animals and providing energy acquisition space, a feeding mechanism 4 and a drinking mechanism 5 are arranged on the front side of the activity mechanism 3, and below the separation and collection mechanism 2 is a storage mechanism 6 for storing feces and urine transported by the separation and collection mechanism 2.

[0047] Embodiment 2:

[0048] like Figure 1-3As shown, a universal metabolic cage for rats and guinea pigs is different from Example 1 in that the frame 1 includes a support plate 13, and a convex ring 15 and a notch 14 for installing a separation and collection mechanism 2 are arranged on the circular notch of the support plate 13. Specifically, a smooth M-shaped structure is provided on the front side of the support plate 13, wherein slide rails 12 for limiting the front and rear positions of the support plate 13 are provided on both sides of the top of the support frame 11, and the support plate 13 is placed above the middle of the two sets of slide rails 12, and the slide rails 12 are installed on the support frame 11, and an inverted cone-shaped circular notch is provided in the center of the support plate 13, and a convex ring 15 for left and right position limiting is provided in the circular notch, and four horizontal equi-angled Y-shaped notches 14 are also provided around the circular notch, and the Y-shaped notch 14 limits the separation cone 23 in the separation and collection mechanism 2 to prevent the separation cone 23 from rotating. Therefore, the support plate 13 supports the entire device, and in addition, the support plate 13 can also be placed on other shelves, and the entire device can be lifted by the handle 321.

[0049] like Figure 2 As shown, the separation and collection mechanism 2 comprises a truncated cone-shaped lower chamber 21 with an open upper end, a collection funnel 22 arranged inside the lower chamber 21, a separation cone 23 and a urine collection ring 24 arranged inside the collection funnel 22, the lower chamber 21 is mounted on the circular notch of the support plate 13 and positioned by a convex ring 15; the upper end of the separation cone 23 is mounted on the notch 14 of the support plate 13 through an arc-shaped bracket 231, and the urine collection ring 24 is mounted on the bottom of the collection funnel 22. The upper end of the collection funnel 22 is a spherical shape with a wide upper end and a narrow lower end, and the lower end is an inclined cone.

[0050] like Figure 4-5 As shown, the separation cone 23 opens downward, and the bottom is four arch structures. A guide point for guiding urine to flow downward in streams is formed between two adjacent arch structures, and the value range of the taper α of the separation cone 23 is 85-90°. The bottom of the separation cone 23 is arc-shaped, so that the two sides of the separation cone 23 are pointed, avoiding the residual amount of urine on the separation cone 23. Since the taper of the separation cone 23 is obtained after a long period of experimental data, if the taper is too large and the speed of urine is high, the urine may flow into the feces storage tube 61, and if the taper is too small, the urine may remain on the separation cone 23, affecting the accuracy of the data. Therefore, the value range of α obtained by experimental data is 85-90°, preferably 88°.

[0051] Specifically, the collecting funnel 22 is movably installed in the lower chamber 21 , the maximum size of the cone opening of the separation cone 23 is larger than the neck size of the collecting funnel 22 , and the separation cone 23 is coaxially installed above the collecting funnel 22 .

[0052] The function of the separation cone 23 is as follows: since the urine and feces of the rat or guinea pig fall from the bottom net 32, if there is no separation cone 23, the urine and feces of the rat or guinea pig will enter the feces storage tube 61. However, since the separation cone 23 is provided, after the urine of the rat or guinea pig passes through the separation cone 23, the urine will drip onto the separation cone 23. Since the urine has a certain viscosity, the urine will flow down along the wall of the separation cone 23, which has a certain deceleration effect and continues to flow downward. It will flow to the inner wall of the collecting funnel 22, flow close to the inner wall of the collecting funnel 22, and then enter the urine collecting ring 24 along the inclined cone at the lower end of the collecting funnel 22. Since the urine collecting ring 24 is inclined and a guide port is opened at the lowest end, the urine finally flows into the urine storage tube 62; if it is normal feces discharged by rats or guinea pigs, since the feces is solid, when passing through the separation cone 23, the speed of coming out is reduced, and then falls into the feces storage tube 61, thereby realizing the separation of urine and feces.

[0053] For example Figure 2 As shown, the storage mechanism 6 includes a feces storage tube 61 and a urine storage tube 62 movably mounted at the bottom of the lower chamber 21. Figure 8-9 As shown, the urine collecting ring 24 is tilted, with a diversion port at the lowest end, and the diversion direction of the lowest end of the urine collecting ring 24 is consistent with the urine storage tube 62; the feces receiving port of the feces storage tube 61 is installed in the conical port at the lower end of the collecting funnel 22.

[0054] Specifically, the feces storage tube 61 is movably installed at the central circular hole at the bottom of the lower chamber 21 and can be installed and removed by rotation. The urine storage tube 62 is movably installed at the circular hole on the side of the bottom of the lower chamber 21 and can be installed and removed by rotation.

[0055] For example Figure 1-2 As shown, the activity mechanism 3 includes an activity chamber 31, a bottom net 32 ​​and a top cover 33. The activity chamber 31 is coaxially movably installed above the separation and collection mechanism 2, the bottom net 32 ​​is arranged between the activity chamber 31 and the separation and collection mechanism 2, and the top cover 33 is detachably installed above the activity chamber 31. The activity chamber 31 is used to limit the activity area of ​​rats or guinea pigs and provide energy acquisition space, and the bottom net 32 ​​is used to penetrate their excrement.

[0056] Specifically, the bottom net 32 ​​is placed between the separation and collection mechanism 2 and the activity chamber 31 and is fully limited. A groove for limiting the top cover 33 is provided at the top of the activity chamber 31. The top cover 33 can be rotated, installed and disassembled through the limiting groove, and a ventilation hole is provided above the top cover 33.

[0057] Since rats or guinea pigs may push down the top cover 33 during experiments, the top cover 33 and the activity chamber 31 are locked by rotation to prevent the rats or guinea pigs from running out. The bottom net 32 ​​is a flat surface for rats or guinea pigs to step on, and two handles 321 are provided on both sides of the bottom net 32 ​​to facilitate the operator to move or place the entire device.

[0058] like Figure 6 As shown, the feeding mechanism 4 includes a silo 42 and a feeding chamber 41 with an open rear end. The silo 42 is slidably connected to both sides of the bottom end of the feeding chamber 41, and a partition 45 is provided in the silo 42. The silo 42 is divided into an outer silo for placing feed and an empty inner silo by the partition 45.

[0059] Specifically, parallel smooth-polished metal wires are arranged at the lower end and the front end of the feeding chamber 41, and the lower end wires are provided with square holes, slide grooves are provided on both sides of the bottom end of the feeding chamber 41, and symmetrical limiting grooves 43 are provided at the front end of the slide grooves, the silo 42 is slidably installed in the slide groove of the feeding chamber 41, and a limiting protrusion 44 that can be fixed with the limiting groove 43 of the feeding chamber 41 is provided at the end of the silo 42, and the limiting protrusion 44 is matched with the limiting groove 43 on the feeding chamber 41. If there is no limiting protrusion 44, rats or guinea pigs may slip out of the feeding chamber 41 and the silo 42 when obtaining feed.

[0060] The feed bin 42 is divided into two bins, an inner bin and an outer bin, by a partition 45. The outer bin is used to store normal feed for rats or guinea pigs, while the inner bin has no feed. The reason is that rats or guinea pigs will drag the objects when eating, and the experiment requires that the objects cannot be dragged into the activity room 31. Therefore, the inner bin needs to be empty. When the rats or guinea pigs drag the objects, they will fall into the inner bin for recovery. Finally, the result of the experiment is to calculate the number of grams of feed eaten by the rats or guinea pigs. Therefore, the number of grams of food eaten by the rats or guinea pigs can be accurately calculated by combining the grams of food eaten and the grams of food dragged, thereby ensuring the accuracy of the experimental results.

[0061] like Figure 7 As shown, the drinking water mechanism 5 includes a drinking water bottle 51, a drinking water bracket 52 and a return pipe 53. The drinking water bracket 52 is installed on the outside of the activity chamber 31. The opening of the drinking water bottle 51 is tilted downward and arranged above the drinking water bracket 52. The return pipe 53 is movably installed below the drinking water bracket 52.

[0062] Specifically, when the drinking bottle 51 is filled with water, the drinking bottle 51 is tilted and placed on the drinking bracket 52 with the water outlet facing downward. Water will flow out only when the rat or guinea pig touches the bottle mouth of the drinking bottle 51. When no object touches the bottle mouth, the water at the bottle mouth will not flow. If the rat or guinea pig does not have drinking water, but the bottle mouth leaks due to vibration of the rat or guinea pig in the cage, the water will flow back into the reflux pipe 53 through the inclined slope at the lower end of the drinking bracket 52, and a small funnel is provided in the reflux pipe 53 to prevent water evaporation. The whole process can accurately calculate the amount of water drunk by the rat or guinea pig, providing accurate data for subsequent experimental results.

[0063] Embodiment 3:

[0064] Data testing of the present invention:

[0065] 1. The experimental purpose of the present invention is to detect the collection accuracy of metabolic cages of rats and guinea pigs.

[0066] 2. Test conditions of the present invention:

[0067] syringe, 50 pellets of rat feces, 30 g of rat urine;

[0068] Note: All mouse excrement is discharged under natural conditions, and the time is ≤1h.

[0069] 3. Test method for universal metabolic cages for rats and guinea pigs:

[0070] S1: Use tweezers to naturally drop 50 pieces of mouse feces from about 1 cm above the bottom net 32, and observe the number and weight of feces in the feces storage tube 61;

[0071] S2: Use a syringe to extract mouse urine, and let it drip naturally from about 1 cm above the bottom net 32 ​​to simulate normal mouse defecation, and observe the weight of urine in the urine storage tube 62;

[0072] S3: Repeat the test 20 times and calculate the average value. The calculation formula is:

[0073] H=m / M

[0074] H n =(m1+m2+m3+…+m n ) / (M1+M2+M3+…+M n )

[0075] Among them, H represents the recovery accuracy; m represents the weight after the experiment; M represents the weight before the experiment; H n Represents the average recovery precision.

[0076] 4. The test data is:

[0077] Table 1: Experimental data 1

[0078]

[0079] The conclusion drawn from Table 1 is that when the present invention is used, almost all feces particles are recovered, with a collection rate of 99.9%. The uncollected feces are stuck between the separation cone 23 and the collection funnel 22 due to excessive humidity.

[0080] Table 2: Experimental data 2

[0081]

[0082]

[0083] The conclusion drawn from Table 2 is that when the present invention is used, the feces recovery accuracy is 99.4%, and the urine recovery accuracy is 96.4%.

Claims

1. A universal metabolic cage for rats and guinea pigs, comprising a frame (1), characterized in that: The frame (1) is provided with a separation and collection mechanism (2) for separating and transporting feces and urine; an activity mechanism (3) for limiting the activity area of ​​experimental animals and providing energy acquisition space is provided above the separation and collection mechanism (2); a feeding mechanism (4) and a drinking mechanism (5) are provided at the front side of the activity mechanism (3); and a storage mechanism (6) for storing feces and urine is provided below the separation and collection mechanism (2).

2. The universal metabolic cage for rats and guinea pigs according to claim 1, characterized in that: The frame (1) comprises a support plate (13), and a convex ring (15) and a notch (14) for mounting a separation and collection mechanism (2) are arranged on the circular notch of the support plate (13).

3. The universal metabolic cage for rats and guinea pigs according to claim 2, characterized in that: The separation and collection mechanism (2) comprises a lower chamber (21) with an open upper end, a collection funnel (22) arranged inside the lower chamber (21), a separation cone (23) and a urine collection ring (24) arranged inside the collection funnel (22); the lower chamber (21) is mounted on a circular notch of a support plate (13) and positioned by a convex ring (15); the upper end of the separation cone (23) is mounted on the notch (14) of the support plate (13) by means of an arc-shaped bracket (231); and the urine collection ring (24) is mounted on the bottom of the collection funnel (22).

4. The universal metabolic cage for rats and guinea pigs according to claim 3, characterized in that: The separation cone (23) opens downward, and has four arch structures at the bottom. A guide point for guiding urine to flow downward in streams is formed between two adjacent arch structures, and the taper α of the separation cone (23) has a value range of 85 to 90°.

5. The universal metabolic cage for rats and guinea pigs according to claim 3, characterized in that: The storage mechanism (6) comprises a feces storage tube (61) and a urine storage tube (62) movably mounted at the bottom of the lower chamber (21); the urine collecting ring (24) is arranged obliquely, and a diversion port is provided at the lowest end, and the diversion direction of the lowest end of the urine collecting ring (24) is consistent with that of the urine storage tube (62); the feces receiving port of the feces storage tube (61) is mounted in the conical port at the lower end of the collecting funnel (22).

6. The universal metabolic cage for rats and guinea pigs according to claim 5, characterized in that: The movable mechanism (3) comprises an movable chamber (31), a bottom net (32) and a top cover (33); the movable chamber (31) is coaxially movably mounted above the separation and collection mechanism (2); the bottom net (32) is arranged between the movable chamber (31) and the separation and collection mechanism (2); and the top cover (33) is detachably mounted above the movable chamber (31).

7. The universal metabolic cage for rats and guinea pigs according to any one of claims 1 to 5, characterized in that: The feeding mechanism (4) comprises a silo (42) and a feeding chamber (41) with an open rear end. The silo (42) is slidably connected to both sides of the bottom of the feeding chamber (41). A partition (45) is provided in the silo (42). The silo (42) is divided into an outer silo for placing feed and an empty inner silo by the partition (45).

8. The universal metabolic cage for rats and guinea pigs according to claim 7, characterized in that: The drinking water mechanism (5) comprises a drinking water bottle (51), a drinking water support (52) and a return pipe (53); the drinking water support (52) is installed outside the activity room (31); the opening of the drinking water bottle (51) is arranged above the drinking water support (52) in a downwardly inclined manner; and the return pipe (53) is movably installed below the drinking water support (52).

9. A test method, using the universal metabolic cage for rats and guinea pigs as claimed in claim 6, characterized in that: The following steps are involved: S1: Use tweezers to drop 50 pieces of mouse feces naturally from about 1 cm above the bottom net (32), and observe the number and weight of feces in the feces storage tube (61); S2: Use a syringe to extract mouse urine, and let it drip naturally from about 1 cm above the bottom net (32) to simulate normal mouse defecation, and observe the weight of urine in the urine storage tube (62); S3: Repeat the test 20 times and calculate the average value. The calculation formula is: H=m / M H n =(m1+m2+m3+…+m n ) / (M1+M2+M3+…+M n ) Among them, H represents the recovery accuracy; m represents the weight after the experiment; M represents the weight before the experiment; H n Represents the average recovery precision.

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