Composition for preventing hair loss and promoting hair growth and application thereof

Abstract

The invention discloses a composition for preventing hair loss and promoting hair growth and application thereof. The composition is prepared from pea seedling concentrated powder, fermented ginseng powder and gamma-aminobutyric acid, wherein the content of the pea seedling concentrated powder is 5-30 parts by mass, the content of the fermented ginseng powder is 1-5 parts by mass, and the content of the gamma-aminobutyric acid is 5-30 parts by mass. Cell experiments prove that the hair conditioner can reduce the proportion of hair follicles entering a resting period by improving proliferation and migration of human hair papilla cells so as to achieve the effects of hair loss prevention and hair care.

Description

Technical Field

[0001] The invention belongs to the field of functional compositions, and in particular relates to a composition for preventing hair loss and promoting hair growth and application thereof. Background Art

[0002] As an appendage of the head skin, hair has the functions of protecting the brain and scalp, resisting physical impact, having beautiful social attributes, and reflecting the diagnostic function of human health. Hair grows at an average rate of 0.35 mm per day, and under normal circumstances, a person loses about 100 hairs per day. The hair growth cycle is characterized by three different stages: the growth stage (anagen), the apoptosis-mediated degradation transition period (catagen), and the relative resting period (telogen), during which the hair is released from the follicle and falls off. Through periodic shedding and new hair growth, the number of hairs remains relatively constant, with about 85-90% of the hair follicles in the anagen stage. When the proportion of hair in the telogen phase increases and the proportion of hair in the growth phase decreases, pathological hair loss occurs. In severe cases, symptoms such as alopecia areata and baldness may occur, greatly affecting the patient's aesthetic image and health.

[0003] About half of men and 40% of women experience pathological hair loss by the age of 50. This can be caused by a variety of factors, including hormonal changes, poor nutrition, stress, medication use or genetics.

[0004] Although there are many treatment methods such as topical minoxidil and finasteride, patients often suffer from side effects such as tachycardia and sex hormone imbalance. Therefore, consumers and the industry strive to achieve the effect of preventing hair loss and promoting hair growth through oral administration of natural effective ingredients in the form of dietary supplements or functional foods. However, the latter often have poor application effects. Summary of the invention

[0005] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0006] In view of the above problems and / or the problems existing in the prior art, the present invention is proposed.

[0007] Therefore, the object of the present invention is to overcome the deficiencies in the prior art and provide a composition for preventing hair loss and promoting hair growth.

[0008] In order to solve the above technical problems, the present invention provides the following technical solutions: a composition for preventing hair loss and promoting hair growth, comprising pea seedling concentrated powder, fermented ginseng powder and gamma-aminobutyric acid;

[0009] Wherein, in terms of mass, the pea sprout concentrated powder is 5 to 30 parts, the fermented ginseng powder is 1 to 5 parts, and the gamma-aminobutyric acid is 5 to 30 parts.

[0010] As a preferred embodiment of the composition of the present invention, the pea sprout concentrated powder is 15 to 30 parts by weight, the fermented ginseng powder is 1 to 3 parts by weight, and the γ-aminobutyric acid is 15 to 30 parts by weight.

[0011] As a preferred embodiment of the composition of the present invention, the pea sprout concentrated powder is 20 parts, the fermented ginseng powder is 3 parts, and the γ-aminobutyric acid is 20 parts by mass.

[0012] Another object of the present invention is to overcome the deficiencies in the prior art and provide a method for preparing a hair loss prevention and hair growth composition, comprising:

[0013] The pea sprout concentrated powder, fermented ginseng powder and gamma-aminobutyric acid are uniformly mixed to prepare the composition.

[0014] As a preferred embodiment of the method for preparing the composition of the present invention, the pea sprout concentrated powder is 5 to 30 parts by weight, the fermented ginseng powder is 1 to 5 parts by weight, and the γ-aminobutyric acid is 5 to 30 parts by weight.

[0015] As a preferred embodiment of the method for preparing the composition of the present invention, the pea sprout concentrated powder is 20 parts, the fermented ginseng powder is 3 parts, and the γ-aminobutyric acid is 20 parts by weight.

[0016] Another object of the present invention is to overcome the deficiencies in the prior art and provide an anti-hair loss and hair growth composition for use in preparing food.

[0017] As a preferred embodiment of the application of the present invention, the food includes health food and ordinary food.

[0018] As a preferred embodiment of the application of the present invention, the dosage forms of the common food and health food include soft capsules, tablets, gel candies, liquid beverages, jellies and solid beverages.

[0019] Another object of the present invention is to overcome the deficiencies in the prior art and provide an anti-hair loss and hair growth composition for use in the preparation of an anti-hair loss and hair growth pharmaceutical composition.

[0020] Beneficial effects of the present invention:

[0021] (1) The present invention provides a composition for preventing hair loss and promoting hair growth. The composition comprises pea sprout concentrated powder, fermented ginseng powder and gamma-aminobutyric acid. When the proportion of pea sprout concentrated powder is 5 to 30 parts, fermented ginseng powder is 1 to 5 parts and gamma-aminobutyric acid is 5 to 30 parts, cell experiments have shown that the composition can reduce the proportion of hair follicles entering the resting phase by increasing the proliferation and migration of human hair papilla cells, thereby achieving the effect of preventing hair loss and protecting hair.

[0022] (2) All ingredients in the composition of the present invention are common food raw materials permitted for use by laws and regulations and are highly safe; the composition has the effect of promoting the proliferation and migration of human papillary hair cells and reducing the proportion of hair follicles in the resting phase, thereby achieving the effect of reducing the amount of hair loss and increasing the amount of hair per unit area. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:

[0024] Figure 1 The results of the proliferation of hDPCs human dermal papilla cells by the ginseng and pea seedling γ-aminobutyric acid composition with different proportions in the examples of the present invention are shown.

[0025] Figure 2 This is a migration diagram and result of detecting hDPCs human dermal papilla cells in an embodiment of the present invention.

[0026] Figure 3 The hair loss count of the subject was 60 times combing the hair before and after taking the medicine in the embodiment of the present invention.

[0027] Figure 4 It is the number of hair per unit area before and after taking the medicine in the embodiment of the present invention.

[0028] Figure 5 The figure shows the change in hair diameter before and after the test subject takes the medicine in the embodiment of the present invention. DETAILED DESCRIPTION

[0029] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0030] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0031] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0032] The pea sprout concentrated powder in the embodiment of the present invention is a commercially available standard specification product; the γ-aminobutyric acid is fermented from a fermentation source, has a purity of 98%, and is a commercially available standard specification product; the fermented ginseng powder has a customized rare saponin specification of >=2%, and is commercially available.

[0033] In the present invention, the raw materials are weighed according to the proportion and mixed to form the composition.

[0034] The composition of the present invention is prepared into preparations by adding auxiliary materials such as pectin, citric acid monohydrate, erythritol, sucralose, violet essence, peach essence, purified water and thickener, mainly including oral liquid, beverage, solid beverage, soft candy, soft capsule, gel candy, jelly, tablet and other dosage forms, which are used in food, health food and medical fields.

[0035] Example 1

[0036] This embodiment provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0037] (1) Prepare raw materials: weigh 20 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 20 parts of γ-aminobutyric acid by mass;

[0038] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0039] Example 2

[0040] This embodiment provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0041] (1) Prepare raw materials: weigh 5 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 20 parts of γ-aminobutyric acid by mass;

[0042] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0043] Example 3

[0044] This embodiment provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0045] (1) Prepare raw materials: weigh 30 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 20 parts of γ-aminobutyric acid by mass;

[0046] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0047] Example 4

[0048] This embodiment provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0049] (1) Prepare raw materials: weigh 20 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 5 parts of γ-aminobutyric acid by weight;

[0050] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0051] Example 5

[0052] This embodiment provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0053] (1) Prepare raw materials: weigh 20 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 30 parts of γ-aminobutyric acid by mass;

[0054] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0055] Comparative Example 1

[0056] This comparative example provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0057] (1) Prepare raw materials: weigh 35 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 20 parts of γ-aminobutyric acid by mass;

[0058] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0059] Comparative Example 2

[0060] This comparative example provides a composition for preventing hair loss and promoting hair growth and its preparation process:

[0061] (1) Prepare raw materials: weigh 20 parts of pea sprout concentrated powder, 3 parts of fermented ginseng powder, and 35 parts of γ-aminobutyric acid by weight;

[0062] (2) Preparing a composition: The raw materials prepared in step (1) are mixed evenly according to a certain proportion to prepare a composition for preventing hair loss and promoting hair growth.

[0063] The proportions of the embodiments and comparative examples are shown in Table 1.

[0064] Table 1

[0065] Pea sprout concentrate powder (number of servings) GABA (parts) Fermented ginseng powder (number of servings) Blank control / / / Example 1 20 20 3 Example 2 5 20 3 Example 3 30 20 3 Example 4 20 5 3 Example 5 20 30 3 Comparative Example 1 35 20 3 Comparative Example 2 20 35 3

[0066] Proliferation and migration experiments of the composition of the present invention on human dermal papilla cells:

[0067] (1) Reagents and instruments:

[0068] Reagents: PBS buffer, CCK8 solution, mesenchymal stem cell-specific basal medium, mesenchymal stem cell-specific complete medium (containing 5% FBS, 1% double antibody, 1% growth factor);

[0069] HDPC (human dermal papilla cells), fermented ginseng powder and pea seedling gamma-aminobutyric acid composition (125 μg / mL);

[0070] In the specific experimental process, in the cell experiment, the total concentration of all compositions was uniformly 125 μg / mL, that is, all comparative examples and embodiments were uniformly concentrated at 125 μg / mL, wherein the proportion of the added amount of the composition is shown in Table 1.

[0071] Instruments: incubator, water bath, centrifuge, inverted microscope, microplate reader.

[0072] (2) Experimental methods:

[0073] ① Cell culture: hDPCs were inoculated in DMEM solution containing 10% FBS and 1% double antibody, incubated in a constant temperature incubator at 37°C and 5% CO2, and fresh culture medium was replaced every 1-2 days. When the cell density reached 70%-80%, trypsin was used for digestion to separate the adherent cells. The digested cells were placed in a 15mL centrifuge tube and centrifuged at 1000-1500rpm for 5 minutes. The centrifuged cells were passaged or frozen;

[0074] The cells being passaged can be passaged as required (1:3 or 1:4), and can be used for subsequent experiments when they are passaged to the 3rd to 5th generation.

[0075] ②Cell proliferation: Add 100 μL of cell suspension (about 5*103 cells / well) to a 96-well plate and place it in a 37°C incubator for pre-culture for 24 hours. Then, add 10 μL of material solution of different concentrations to the experimental wells.

[0076] Place the 96-well plate in an incubator and incubate for about 24 hours. When the cells grow to 70%-80%, add 10 μL of CCK solution to each well (be careful not to generate bubbles that will affect the OD value reading). Then incubate the 96-well plate in the incubator for 1-4 hours and measure the absorbance at 450 nm with an enzyme reader.

[0077] Cell viability (%) = 100*[A(test material)-A(blank)] / [A(0 drug addition)-A(blank)];

[0078] A (test material): absorbance value of the wells containing cells, CCK-8 solution and test material;

[0079] A(blank): absorbance value of the well with CCK-8 solution;

[0080] A (0 drug addition): absorbance value of the wells containing cells and CCK-8 solution but no test material.

[0081] Cell proliferation rate (%) = cell viability % - 100%

[0082] ③Cell migration: The DMEM cell suspension containing 10% fetal bovine serum and 1% double antibody was spread in a 6-well plate (about 3*104 density), and cultured in a 37°C incubator to 90% density. The cells were drawn in a straight line using a 200 μL pipette tip, and then washed with DPBS solution. The material solution (125 μg / mL) was added for treatment. After culturing for 24 hours, the cells were photographed and observed using an optical microscope.

[0083] Cell migration rate % = 100*[A(0h scratch blank area)-A(24h scratch blank area)]

[0084] (3) Test results

[0085] Effect of different proportions of ginseng and pea seedling γ-aminobutyric acid composition on the proliferation of hDPCs human dermal papilla cells Figure 1 It can be seen that the ginseng and pea sprout γ-aminobutyric acid compositions of different proportions in Example 1 and Example 3 have a greater effect on the proliferation of hDPCs human dermal papilla cells. Among them, sample 1, when the ratio of fermented ginseng: pea sprout concentrated powder: γ-aminobutyric acid is 3:20:20, has the best effect in promoting cell proliferation.

[0086] The migration diagram of hDPCs human dermal papilla cells after treatment with sample 1 and blank control in Example 1 of the present invention is shown in FIG. Figure 2 From the cell migration photos, it can be seen that the migration area of ​​hDPCs cells treated with sample 1 is significantly larger than that of the blank control;

[0087] From the analysis results of cell migration rate, it can be seen that in sample 1, when the ratio of fermented ginseng: pea sprout concentrated powder: γ-aminobutyric acid is 3:20:20, the effect of promoting cell migration is the best.

[0088] Example 6

[0089] Experimental study on the efficacy of the composition of the present invention in preventing hair loss and protecting hair on human subjects:

[0090] (1) Experimental instruments: scalp detector QM-Scalp-002 (Qianmei Health); LED light source: wavelength 450-750nm, color temperature 6500-8000K, illumination not less than 540lx;

[0091] Comb: The tooth density is moderate (tooth spacing 0.9-1.1mm), the tooth length is 2.0-3.0cm, and the comb length is not less than 10cm (excluding the comb handle). The comb of the same specification and material must be used throughout the test. After each use, it must be disinfected in accordance with the relevant requirements of the Technical Specifications for Disinfection of Medical Institutions (WS-T 367-2012).

[0092] (2) Experimental methods:

[0093] The subjects were randomly divided into a placebo group and a sample group (Example 1), with 7 subjects in the placebo group and 13 subjects in the sample group;

[0094] The subjects in the sample group took one bottle of ginseng pea sprout γ-aminobutyric acid sample every day (each bottle of sample contained 20 parts of pea sprout concentrated powder, 20 parts of γ-aminobutyric acid, 3 parts of fermented ginseng powder, and the added auxiliary materials included 4600 parts of water, 400 parts of erythritol, 0.5 parts of sucralose, 18 parts of citric acid monohydrate, 10 parts of edible flavors, and 10 parts of pectin);

[0095] The subjects in the placebo group took one bottle of ginseng pea sprout γ-aminobutyric acid placebo (made of 4600 parts of water, 400 parts of erythritol, 0.5 parts of sucralose, 18 parts of citric acid monohydrate, 10 parts of edible flavors, and 10 parts of pectin) every day;

[0096] Detection was performed at T0, T28 and T56.

[0097] Among them, the subjects were grouped using a single-blind design, and the subjects were kept blind during the study; during the entire study process, only the principal researcher and assistant researcher were non-blind personnel, and the rest of the personnel were set as blind; the main indicators of this trial were all objective instrument indicators, which reduced the data bias caused by the non-blindness of the researchers.

[0098] Blind procedure:

[0099] The assistant researcher used SPPS to generate random numbers and then established a random table. The eligible subjects were screened and randomly grouped according to the random table in the order of enrollment. At the same time, the assistant researcher uniformly coded the placebo and test samples, and distributed the samples / placebos with different codes but the same appearance to the subjects according to the grouping situation.

[0100] Data analysis and processing methods: Instrument measurement part: Mean Value, Standard Deviation; Difference statistics: All tests are one-sided tests, and the test level is α = 0.05. Inter-group comparison: If the data presents a normal distribution, a parametric test (independent sample T test) will be used; if the data does not conform to the normal distribution, a non-parametric test will be used. Self-comparison: If the data presents a normal distribution, a parametric test (paired sample T test) will be used; if the data does not conform to the normal distribution, a non-parametric test will be used.

[0101] (3) Scalp analyzer takes pictures and software analyzes:

[0102] Determine the type of hair loss: Use a 1x lens and "cuticle" light to shoot, with the Baihui point on the top of the subject's head as the center, about 20 cm from the top of the head, with the head centered, leaving equal space on both sides, and shoot the entire head;

[0103] For subjects with obvious hair loss areas, such as the back of the head, near the ear, and the back of the head, additional photos should be taken at the hair loss area, and photos should be taken at the same distance at each follow-up visit to facilitate comparison;

[0104] Detect the epidermis, basal layer and stratum corneum of the scalp: After replacing the 60x lens, the blue light source is used to capture the scalp status and the number of hairs per unit area;

[0105] Detect the status of individual pores and hair diameter: After changing to a 150x microscope, detect the pores at the top of the head at the hairline and hair flow (vortex) and take photos to measure the hair diameter;

[0106] To analyze the results, drag the corresponding photos taken into the corresponding boxes of each indicator in the analysis software for analysis. For the number of hairs, count them in the photos to obtain the hair density per unit area. For the hair diameter, drag the mouse 3 times to get the average value.

[0107] For subjects with obvious hair loss areas, repeat steps 2-4 above for the hair loss areas to take photos and analyze the test. For subjects without obvious hair loss areas, select another parting or hair whorl and repeat steps 2-4 above for taking photos and analyzing the test.

[0108] (4) Measurement of hair loss:

[0109] Volunteer subjects were recruited according to the requirements and signed written informed consent. Before enrollment, subjects were asked a series of questions about medical history, health status, etc. according to the inclusion and exclusion criteria. At the same time, the number of hair loss was counted and recorded using the 60-combing method.

[0110] The selected subjects were evaluated for hair basal values ​​before taking the samples, including hair loss count, hair density assessment and image capture, and recorded; the same evaluation and testing were performed again 4 weeks and 8 weeks after taking the samples.

[0111] Hair loss count: During each visit, trained staff combed the subject's hair 60 times, counted the fallen hair, and recorded it.

[0112] The experimental results can be found in Figures 3 to 5 :

[0113] 1. Compared with before taking the drug, the number of hair loss in the sample group was significantly reduced by 45.46% after 4 weeks and by 54.94% after 8 weeks, while the change in the number of hair loss in the placebo group was not statistically significant. The improvement rate of hair loss in the sample group was 42.26% after taking the sample for 4 weeks and by 53.95% after 8 weeks, which was significantly improved compared with the placebo group.

[0114] 2. Compared with before taking the drug, the number of hair per unit area of ​​the subjects in the sample group increased significantly by 33.12% after 4 weeks, and increased significantly by 67.82% after 8 weeks, while the change in the number of hair per unit area in the placebo group was not statistically significant. The improvement rate of the number of hair per unit area of ​​the subjects in the sample group was 48.54% after taking the sample for 4 weeks, and 61.55% after 8 weeks, which was significantly improved compared with the placebo group.

[0115] 3. Compared with before taking the drug, the hair diameter of the subjects in the sample group increased significantly by 16.04% after 4 weeks and by 16.28% after 8 weeks, while the change in hair diameter in the placebo group was not statistically significant.

[0116] The composition of the invention has the effect of promoting the proliferation and migration of human dermal hair papilla cells, thereby alleviating the symptoms of hair loss and increasing the hair density per unit scalp area.

[0117] The purpose of the present invention is to find a reasonable composition and ratio, so that it can have a better anti-hair loss and care effect in a short time, and its mechanism is to promote the proliferation and migration of human hair papilla cells, thereby reducing the proportion of hair follicles entering the resting phase.

[0118] The anti-hair loss and hair growth composition of the present invention can be prepared into a fermented ginseng pea seedling γ-aminobutyric acid composition oral liquid beverage. Preferably, the beverage can be prepared by adding auxiliary materials to the composition, and the auxiliary materials include at least one of water, sorbitol, erythritol, sucralose, citric acid monohydrate, edible flavors, pectin, fruit juice, and thickeners. Preferably, the beverage can be prepared by processes such as material preparation, gelatinization, dissolution, blending, pH adjustment, volume setting, UHT sterilization, encapsulation, and two-stage pasteurization.

[0119] The anti-hair loss and hair growth composition of the present invention is prepared by optimizing the proportion of pea sprout concentrated powder, fermented ginseng powder and gamma-aminobutyric acid. When the proportions of pea sprout concentrated powder are 5 to 30 parts, fermented ginseng powder is 1 to 5 parts and gamma-aminobutyric acid is 5 to 30 parts, cell experiments have verified that the composition can reduce the proportion of hair follicles entering the resting phase by increasing the proliferation and migration of human hair papilla cells, thereby achieving the effect of preventing hair loss and protecting hair. At the same time, further studies have found that in the formula system, the fermented ginseng powder and gamma-aminobutyric acid have a synergistic effect on improving the effect of preventing hair loss and protecting hair.

[0120] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the present invention.

Claims

1. A composition for preventing hair loss and promoting hair growth, characterized in that: include, Pea sprout concentrate powder, fermented ginseng powder, and gamma-aminobutyric acid; Wherein, in terms of mass, the pea sprout concentrated powder is 5 to 30 parts, the fermented ginseng powder is 1 to 5 parts, and the gamma-aminobutyric acid is 5 to 30 parts.

2. The composition according to claim 1, characterized in that: In terms of weight, the pea sprout concentrated powder is 15 to 30 parts, the fermented ginseng powder is 1 to 3 parts, and the gamma-aminobutyric acid is 15 to 30 parts.

3. The composition according to claim 1 or 2, characterized in that: In terms of mass, the pea sprout concentrated powder is 20 parts, the fermented ginseng powder is 3 parts, and the gamma-aminobutyric acid is 20 parts.

4. A method for preparing a composition according to any one of claims 1 to 3, characterized in that: include, The pea sprout concentrated powder, fermented ginseng powder and gamma-aminobutyric acid are uniformly mixed to prepare the composition.

5. The preparation method according to claim 4, characterized in that: In terms of weight, the pea sprout concentrated powder is 5 to 30 parts, the fermented ginseng powder is 1 to 5 parts, and the gamma-aminobutyric acid is 5 to 30 parts.

6. The preparation method according to claim 5, characterized in that: In terms of mass, the pea sprout concentrated powder is 20 parts, the fermented ginseng powder is 3 parts, and the gamma-aminobutyric acid is 20 parts.

7. Use of the composition according to any one of claims 1 to 3 in preparing food.

8. The use according to claim 7, characterized in that: The food includes health food and ordinary food.

9. The use according to claim 8, characterized in that: The dosage forms of the health food and common food include soft capsules, tablets, gel candies, jellies, liquid beverages and solid beverages.

10. Use of the composition according to any one of claims 1 to 3 in the preparation of a pharmaceutical composition for preventing hair loss and promoting hair growth.

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