Traditional Chinese medicine composition for reducing phlegm and dampness and dispersing nodules and preparation process of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for reducing phlegm and dampness and dispersing nodules and a preparation process thereof, and relates to the technical field of traditional Chinese medicine preparation, and the preparation process comprises the following steps: cleaning medicinal materials, crushing and pretreating, extracting the treated medicinal materials by using an ultrasonic-assisted extraction technology, crushing the extracted effective components into superfine powder by using a superfine crushing technology, and preparing the traditional Chinese medicine composition for reducing phlegm and dampness and dispersing nodules. Mixing the ultrafine powder with a 3D printing material, and printing the medicine material into pills by using a photocuring 3D printer, the preparation method has the advantages that the pills with complex internal structures, such as a multilayer structure, a hollow structure and a porous structure, can be constructed through a 3D printing technology, and the special structures can realize accurate control of drug release, so that the preparation method is simple and easy to operate, and the application prospect is wide. The medicine is released according to the preset speed and time, a better treatment effect is achieved, the double-layer structure pill with the outer layer capable of rapidly releasing and the inner layer capable of slowly releasing is designed, the pill can rapidly take effect in a short time, and meanwhile the long-time medicine effect is maintained.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparation, in particular to a Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and a preparation process thereof. Background Art

[0002] The spectrum of diseases in modern society has changed significantly. The incidence of chronic diseases such as cardiovascular disease, diabetes, and tumors is increasing. These complex diseases require comprehensive and long-term treatment plans. Traditional Chinese medicine has unique advantages in treating chronic diseases, but traditional Chinese medicine preparation processes and dosage forms may not meet the needs of long-term treatment of chronic diseases. For example, when treating cardiovascular diseases, drugs need to be able to work continuously and stably to maintain normal blood pressure and blood lipid levels. Traditional Chinese medicine dosage forms may be difficult to achieve ideal blood drug concentrations and duration of action;

[0003] As a treasure of traditional Chinese medicine, Chinese medicine has a long history and rich practical experience. It has always played an important role in the prevention, treatment and rehabilitation of diseases. With the continuous improvement of people's health needs in modern society, there are higher requirements for the efficacy, safety and convenience of Chinese medicine. The development of modern extraction technologies such as supercritical fluid extraction, ultrasonic extraction and microwave extraction has made it possible to extract effective ingredients from Chinese medicine more efficiently and accurately.

[0004] Traditional Chinese medicine dosage forms, such as decoctions, pills, powders, etc., although each has its own characteristics, have limitations in some aspects. Decoctions require long-term boiling, are inconvenient to take, and are not easy to preserve; pills and powders may be insufficient in terms of drug release rate and bioavailability. For this reason, we propose a Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and a preparation process thereof.

[0006] In order to solve the problems raised in the above background technology, the present invention provides the following technical solutions: a Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and a preparation process thereof, comprising a pretreatment of washing and crushing medicinal materials, extracting the treated medicinal materials using an ultrasonic assisted extraction technology, crushing the extracted effective ingredients into ultrafine powder using an ultrafine crushing technology, mixing the ultrafine powder with a 3D printing material, and printing the medicinal materials into pills using a light-curing 3D printer. The specific operation steps of the Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and the preparation process thereof are as follows:

[0007] Step 1: Pre-treatment of medicinal materials: remove impurities from the selected medicinal materials and wash them, and then process the medicinal materials after washing;

[0008] Step 2: crushing the pretreated medicinal materials for the first time, adding the crushed medicinal materials into an ultrasonic cell disruptor, and extracting them using ultrasonic assisted extraction technology;

[0009] Step 3: Using ultrafine grinding technology to grind the extracted coarse powder for a second time to grind it into ultrafine powder;

[0010] Step 4: Add the crushed powder into the 3D printing material and stir evenly at a suitable temperature to form a medicine material;

[0011] Step 5: Place the mixed medicine into the 3D printing device, adjust the size and type of the pills according to the patient's specific conditions, and design the most suitable pills for the individual;

[0012] Step 6: Place the prepared pills in a microwave drying oven for drying. After drying, the pills are packaged using appropriate packaging materials.

[0013] As a further solution of the present invention: in the step 1, the medicinal materials are washed to remove dirt and impurities on the surface, the washed pinellia is screened, the pinellia with a diameter of 1 cm-2 cm is selected, and it is soaked in clean water for 48h-72h, during which the water is changed every 12h, licorice is prepared according to 10%-15% of the weight of the pinellia, and 8-10 times the weight of water is added for decoction, and the decoction is twice, the first time is 1.5h-2h, and the second time is 1h-1.5h, the liquids obtained from the two decoctions are combined, lime is prepared according to 20%-30% of the weight of the pinellia, and the lime is added to water 6-10 times its own weight, and the lime milk obtained after stirring and mixing is uniformly obtained, and the insoluble impurities are filtered to obtain lime liquid, and the soaked pinellia is put into the licorice and lime liquid, The soaking time is 72h-120h, the soaking environment temperature is 20℃-25℃, and the pH value of the soaking liquid is maintained between 12-14, the processed French pinellia is taken out from the soaking liquid, rinsed with clean water for 3-5 times, and then the cleaned French pinellia is put into a low-temperature drying box at 40℃-50℃, and dried for 48h-72h, and the water content of the French pinellia is controlled between 13%-15%, the cleaned tangerine peel is shredded, a pot is heated to 140℃-160℃, wheat bran is sprinkled in, the amount of wheat bran is 10%-15% of the amount of tangerine peel, and the tangerine peel shreds are added when the wheat bran just smokes, and the mixture is quickly turned over for 6min-8min, and the tangerine peel surface is fried until yellow, the tangerine peel and wheat bran mixture is taken out, the wheat bran is sieved out, and the tangerine peel is cooled to complete the processing of the tangerine peel.

[0014] As a further solution of the present invention: in the step 1, the washed Fritillaria thunbergii is soaked in clean water for 2h-4h, the moistened Fritillaria thunbergii is cut into 3mm-5mm thick slices, a stainless steel pot is preheated to 100°C-120°C over a low heat, the cut Fritillaria thunbergii slices are put into the stainless steel pot for frying, the frying time is 10min-15min, when the surface of the Fritillaria thunbergii slices presents a uniform light yellow color, the frying is stopped to obtain the processed Fritillaria thunbergii, the oyster medicinal material is soaked and cleaned, and each soaking time is 10min-15min, change the water 2-3 times, put the cleaned oysters evenly into the drying box, set the temperature in the drying box to 60℃-80℃, the drying time is 48h-72h, control the water content of the oysters between 10%-15%, use an electric calcining furnace to forge the oysters, set the temperature of the electric calcining furnace to 800℃-1000℃, calcine for 1h-2h, after calcining, take out the oysters and place them in a dry and well-ventilated place to cool naturally, and obtain the processed oysters after cooling.

[0015] As a further solution of the present invention: in the step 2, a high-speed rotary pulverizer is used to initially pulverize the processed medicinal materials, the speed of the high-speed rotary pulverizer is set to 10000r / min-15000r / min, the pulverizing time is set to 1min-3min, the cutter is a blade type, the feed speed is set to 0.5kg / min-2kg / min, the processed tangerine peel and thunbergii are pulverized into 40-80 mesh particles, and then the speed of the high-speed rotary pulverizer is set to 20000r / min-30000r / min, the pulverizing time is set to 5min-10min, the cutter is a hammer type, and the feed speed is The method is set to 0.5kg / min-2kg / min, the processed French pinellia and oyster can be crushed into 80-100 mesh particles, the crushed medicinal powder is added into an ultrasonic crusher for extraction, the power of the ultrasonic cell crusher is set to 200W-600W, the frequency is set to 20kHz-100kHz, the extraction time is set to 15min-60min, the solvent is a water-ethanol mixed solvent, the mixing ratio is 30% water-70% ethanol, the temperature is set to 40℃-60℃, the ratio of the solvent volume to the medicinal material volume is 5-20:1, and after the ultrasonic extraction is completed, the extract is filtered to separate the solid residue to obtain a filtrate containing effective ingredients.

[0016] As a further scheme of the present invention: in the step 2, the extracted filtrate is added to a rotary evaporator for reduced pressure concentration, the vacuum degree in the rotary evaporator is set to 1kPa-4kPa, the temperature is set to 30℃-50℃, and the rotation speed is set to 60r / min-120r / min. After the concentration is completed, the heating is stopped, and the system is slowly restored to a normal pressure state. The concentrated filtrate is taken out from the optional evaporator, and the filtrate is placed in a freezing chamber with a temperature between -20℃--40℃ for pre-freezing, and the freezing time is set to 2h-4h. After the pre-freezing is completed, the filtrate is placed in a freeze dryer, the pressure in the freeze dryer is set to 10Pa-100Pa, the temperature is set to -10℃--20℃, and the drying time is set to 12h-24h. After the drying is completed, the powder is taken out from the freeze dryer.

[0017] As a further solution of the present invention: in the step three, the coarse granular powder after extraction and drying is added to an airflow ultrafine pulverizer for secondary pulverization, the air intake pressure of the airflow ultrafine pulverizer is set to 0.4MPa-0.8MPa, the feed rate is set to 0.5kg / h-2kg / h, the air flow rate is set to 100m / s-300m / s, and the pulverization time is set to 5min-15min. During the pulverization process, samples are taken out every 2min-3min, and the particle size is detected by a laser particle size analyzer. When the particle size reaches 1-100um, the pulverization is stopped, and the coarse granular powder can be pulverized into ultrafine powder.

[0018] As a further scheme of the present invention: in the step 4, polyethylene glycol is used as a 3D printing material, the molecular weight of the polyethylene glycol is set to 4000g / mol-6000g / mol, the viscosity is set to 40mPa˙s-220mPa˙s, the concentration is set to 10wt%-20wt%, and the polyethylene glycol, various ultrafine powders and photoinitiators are added to a magnetic stirrer for stirring and mixing. The amount of ultrafine powder is 40%-50% of the amount of polyethylene glycol, and the photoinitiator is riboflavin, the amount of riboflavin is 1%-5% of the amount of polyethylene glycol, the charging amount is 70%-80% of the volume of the stirrer, the stirring speed of the stirrer is set to 500r / min-1500r / min, the temperature is set to 30℃-60℃, and the stirring time is set to 10min-30min. After stirring and mixing, a fluid medicine can be obtained.

[0019] As a further solution of the present invention: in the step five, the mixed medicinal material is placed in a light-curing 3D printer for printing and forming, the wavelength of the light-curing 3D printer is set to 350nm-450nm, the printing layer thickness is set to 0.05mm-0.2mm, the printing speed is set to 10mm / h-50mm / h, the molding platform temperature is set to 20℃-40℃, and the surface treatment is performed after the formed pills are printed out. The uncured polyethylene glycol remaining on the surface of the pills is removed by a cleaning agent. The cleaning agent is selected from a 60%-70% ethanol solution, and the pills are obtained after cleaning.

[0020] As a further solution of the present invention: in step 6, the formed pills are placed in a hot air drying oven for drying, the temperature in the drying oven is set to 60°C-80°C, the drying time is set to 4h-5h, and the ventilation volume is set to 10m 3 / h-30m 3 / h, control the moisture content of the pills between 9% and 14%. After drying, place the pills in a drying box to cool naturally to room temperature, and inspect the appearance of the pills directly with the naked eye, including discoloration, deformation and cracking. Use a disintegration instrument to detect the disintegration time of the pills. Pills that pass the quality inspection are then packaged using plastic bottles, and the drug name, ingredients, usage and dosage, production date and shelf life are marked on the packaging.

[0021] By adopting the above technical solution, compared with the prior art, the beneficial effects of the present invention are:

[0022] 1. The present invention can construct pills with complex internal structures, such as multi-layer structures, hollow structures, porous structures, etc., through 3D printing technology. These special structures can achieve precise control of drug release, so that the drug is released at a preset rate and time, achieving better therapeutic effects. The double-layer structure pills designed with fast release of the outer layer and slow release of the inner layer can take effect quickly in a short time and maintain long-term efficacy. Different medicinal materials and excipients can be selected for printing. The properties and proportions of these materials can be accurately adjusted according to the needs of drug release. Hydrophilic or hydrophobic materials can be selected to control the release rate of drugs in different environments, or biodegradable materials can be selected to achieve gradual release of drugs.

[0023] 2. The present invention can be produced at lower temperature and pressure through 3D printing technology, avoiding the degradation and inactivation of drugs due to factors such as high temperature and high pressure, ensuring the stability and effectiveness of drugs. 3D printing can accurately control the distribution of drugs and excipients, so that the drugs are evenly dispersed in the pills, avoiding local aggregation and uneven distribution of drugs, thereby improving the stability of drugs. The 3D printing process is automated. Once the model and parameters of the pills are designed, the printer can produce quickly and accurately according to the program, greatly reducing the time and errors of manual operation, improving production efficiency, and can print multiple pills at the same time to achieve mass production. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 Schematic diagram of the Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation steps in an embodiment of the present invention. DETAILED DESCRIPTION

[0025] The specific embodiments of the present invention are further described below in conjunction with the accompanying drawings. It should be noted that the description of these embodiments is used to help understand the present invention, but does not constitute a limitation of the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0026] The present invention discloses a Chinese medicine composition for dispelling phlegm and dampness and dispersing nodules and a preparation process thereof, comprising the steps of washing and crushing medicinal materials for pretreatment, extracting the treated medicinal materials by using an ultrasonic-assisted extraction technique, crushing the extracted effective components into ultrafine powder by using an ultrafine crushing technique, mixing the ultrafine powder with a 3D printing material, and printing the medicinal materials into pills by using a light-curing 3D printer. The specific operation steps of the Chinese medicine composition for dispelling phlegm and dampness and dispersing nodules and the preparation process thereof are as follows:

[0027] Step 1: Pre-treatment of medicinal materials: remove impurities from the selected medicinal materials and wash them, and then process the medicinal materials after washing;

[0028] Step 2: crushing the pretreated medicinal materials for the first time, adding the crushed medicinal materials into an ultrasonic cell disruptor, and extracting them using ultrasonic assisted extraction technology;

[0029] Step 3: Using ultrafine grinding technology to grind the extracted coarse powder for a second time to grind it into ultrafine powder;

[0030] Step 4: Add the crushed powder into the 3D printing material and stir evenly at a suitable temperature to form a medicine material;

[0031] Step 5: Place the mixed medicine into the 3D printing device, adjust the size and type of the pills according to the patient's specific conditions, and design the most suitable pills for the individual;

[0032] Step 6: Place the prepared pills in a microwave drying oven for drying. After drying, the pills are packaged using appropriate packaging materials.

[0033] In one embodiment of the present invention: in step 1, the medicinal materials are washed to remove dirt and impurities on the surface, the washed pinellia is screened, the pinellia with a diameter of 1 cm-2 cm is selected, and it is soaked in clean water for 48h-72h, during which the water is changed every 12h, licorice is prepared according to 10%-15% of the weight of the pinellia, 8-10 times the weight of water is added for decoction, and the decoction is twice, the first time is 1.5h-2h, and the second time is 1h-1.5h, the liquids obtained by the two decoctions are combined, lime is prepared according to 20%-30% of the weight of the pinellia, the lime is added to water 6-10 times its own weight, and the lime milk obtained after stirring and mixing is uniformly obtained, the lime milk is filtered to remove insoluble impurities to obtain lime liquid, the soaked pinellia is put into the licorice and lime liquid, and soaked. The soaking time is 72 hours to 120 hours, the soaking environment temperature is 20° C. to 25° C., and the pH value of the soaking liquid is maintained between 12 and 14. The processed French pinellia is taken out from the soaking liquid, rinsed with clean water for 3 to 5 times, and then the cleaned French pinellia is put into a low-temperature drying box at 40° C. to 50° C., and dried for 48 hours to 72 hours, and the water content of the French pinellia is controlled to be between 13% and 15%. The cleaned tangerine peel is shredded, and a pot is heated to 140° C. to 160° C., and wheat bran is sprinkled into the pot, wherein the amount of the wheat bran is 10% to 15% of the amount of the tangerine peel. When the wheat bran just smokes, the tangerine peel shreds are added, and the mixture is quickly turned over. The stir-frying time is 6 minutes to 8 minutes, and the tangerine peel is fried until the surface of the tangerine peel is yellow. The mixture of tangerine peel and wheat bran is taken out, and the wheat bran is sieved out. The tangerine peel is cooled and the processing of the tangerine peel is completed.

[0034] In one embodiment of the present invention: in step 1, the washed Fritillaria thunbergii is soaked in clean water for 2h-4h, the moistened Fritillaria thunbergii is cut into 3mm-5mm thick slices, a stainless steel pot is preheated to 100°C-120°C over a slow fire, the cut Fritillaria thunbergii slices are put into the stainless steel pot for frying, the frying time is 10min-15min, when the surface of the Fritillaria thunbergii slices presents a uniform light yellow color, the frying is stopped to obtain the processed Fritillaria thunbergii, the oyster medicinal material is soaked and cleaned, and each soaking time is 1 0min-15min, change the water 2-3 times, put the cleaned oysters evenly into the drying box, set the temperature in the drying box to 60℃-80℃, the drying time is 48h-72h, control the water content of the oysters between 10%-15%, use an electric calcining furnace to forge the oysters, set the temperature of the electric calcining furnace to 800℃-1000℃, calcine for 1h-2h, after calcining, take out the oysters and place them in a dry and well-ventilated place to cool naturally, and obtain the processed oysters after cooling.

[0035] In one embodiment of the present invention: in step 2, a high-speed rotary pulverizer is used to initially pulverize the processed medicinal materials, the speed of the high-speed rotary pulverizer is set to 10000r / min-15000r / min, the pulverizing time is set to 1min-3min, the cutter is a blade type, the feed speed is set to 0.5kg / min-2kg / min, the processed tangerine peel and thunbergii are pulverized into 40-80 mesh particles, and then the speed of the high-speed rotary pulverizer is set to 20000r / min-30000r / min, the pulverizing time is set to 5min-10min, the cutter is a hammer type, and the feed speed is set to The speed is set to 0.5kg / min-2kg / min, the processed French pinellia and oyster can be crushed into 80-100 mesh particles, and the crushed powder is added to an ultrasonic crusher for extraction. The power of the ultrasonic cell crusher is set to 200W-600W, the frequency is set to 20kHz-100kHz, the extraction time is set to 15min-60min, the solvent is a water-ethanol mixed solvent, the mixing ratio is 30% water-70% ethanol, the temperature is set to 40℃-60℃, the ratio of the solvent volume to the medicinal material volume is 5-20:1, and after the ultrasonic extraction is completed, the extract is filtered and the solid residue is separated to obtain a filtrate containing effective ingredients.

[0036] In one embodiment of the present invention: in step 2, the extracted filtrate is added to a rotary evaporator for reduced pressure concentration, the vacuum degree in the rotary evaporator is set to 1kPa-4kPa, the temperature is set to 30℃-50℃, and the rotation speed is set to 60r / min-120r / min. After the concentration is completed, the heating is stopped, and the system is slowly restored to a normal pressure state. The concentrated filtrate is taken out from the optional evaporator, and the filtrate is placed in a freezing chamber with a temperature between -20℃--40℃ for pre-freezing, and the freezing time is set to 2h-4h. After the pre-freezing is completed, the filtrate is placed in a freeze dryer, the pressure in the freeze dryer is set to 10Pa-100Pa, the temperature is set to -10℃--20℃, and the drying time is set to 12h-24h. After the drying is completed, the powder is taken out from the freeze dryer.

[0037] In one embodiment of the present invention: in step three, the coarse granular powder after extraction and drying is added into an airflow type ultrafine pulverizer for secondary pulverization, the air intake pressure of the airflow type ultrafine pulverizer is set to 0.4MPa-0.8MPa, the feed rate is set to 0.5kg / h-2kg / h, the air flow rate is set to 100m / s-300m / s, and the pulverization time is set to 5min-15min. During the pulverization process, samples are taken out every 2min-3min, and the particle size is detected by a laser particle size analyzer. When the particle size reaches 1-100um, the pulverization is stopped, and the coarse granular powder can be pulverized into ultrafine powder.

[0038] In one embodiment of the present invention: in step 4, polyethylene glycol is used as a 3D printing material, the molecular weight of polyethylene glycol is set to 4000g / mol-6000g / mol, the viscosity is set to 40mPa˙s-220mPa˙s, the concentration is set to 10wt%-20wt%, and the polyethylene glycol, various ultrafine powders and photoinitiators are added to a magnetic stirrer for stirring and mixing. The amount of ultrafine powder is 40%-50% of the amount of polyethylene glycol, and the photoinitiator is riboflavin, the amount of riboflavin is 1%-5% of the amount of polyethylene glycol, the charging amount is 70%-80% of the volume of the stirrer, the stirring speed of the stirrer is set to 500r / min-1500r / min, the temperature is set to 30℃-60℃, and the stirring time is set to 10min-30min. After stirring and mixing, a fluid medicine can be obtained.

[0039] In one embodiment of the present invention: in step five, the mixed medicinal material is placed in a light-curing 3D printer for printing, the wavelength of the light-curing 3D printer is set to 350nm-450nm, the printing layer thickness is set to 0.05mm-0.2mm, the printing speed is set to 10mm / h-50mm / h, the molding platform temperature is set to 20℃-40℃, and the surface treatment is performed after the molded pills are printed out. The uncured polyethylene glycol remaining on the surface of the pills is removed by a cleaning agent. The cleaning agent is selected from a 60%-70% ethanol solution, and the pills are obtained after cleaning.

[0040] In one embodiment of the present invention: in step six, the formed pills are placed in a hot air drying oven for drying, the temperature in the drying oven is set to 60°C-80°C, the drying time is set to 4h-5h, and the ventilation volume is set to 10m 3 / h-30m 3 / h, control the moisture content of the pills between 9% and 14%. After drying, place the pills in a drying box to cool naturally to room temperature, and inspect the appearance of the pills directly with the naked eye, including discoloration, deformation and cracking. Use a disintegration instrument to detect the disintegration time of the pills. Pills that pass the quality inspection are then packaged using plastic bottles, and the drug name, ingredients, usage and dosage, production date and shelf life are marked on the packaging.

[0041] Embodiment 1, medicinal material itself contains toxic components, these toxic components can be reduced or removed by processing, at the same time, the performance of medicinal material can be changed by processing, and its effects of resolving phlegm and removing dampness, descending adverse reaction and stopping vomiting are enhanced. After processing, various medicinal materials are initially crushed using a high-speed rotary mill, the speed of the high-speed rotary mill is set to 10000r / min, the crushing time is set to 2min, a blade-type tool is used, and the feed rate is set to 1kg / min, and the processed tangerine peel and thunbergia thunbergii are crushed into 60-mesh particles, which can ensure that there is enough specific surface area to dissolve the effective ingredients, and the filtering process will not be difficult due to the excessively fine particles. The speed of the high-speed rotary mill is set to 20000r / min, the crushing time is set to 6min, a hammer-type tool is used, and the feed rate is set to 1kg / min, and the processed pinellia and oyster can be crushed into 100-mesh particles, and the finer particles enable the ultrasonic energy to act more deeply on the inside of the cell, promoting the release of the effective ingredients.

[0042] Embodiment two, after the initial crushing of medicinal materials, adopt ultrasound-assisted extraction technology, thunbergii bulb, dried orange peel, pinellia tuber and oyster are processed, utilize ultrasonic cavitation, mechanical effect and thermal effect, destroy its cell wall, make internal effective ingredient more easily release in subsequent processing, for thunbergii bulb and dried orange peel, the power of ultrasonic cell disruptor can be set to 400W, the frequency is set to 60kHz, the working time is set to 15min, the microjet that high-frequency ultrasound produces is finer, and the crushing effect on cell is relatively warm, for the medicinal materials that pinellia tuber and oyster are hard in texture and thicker in cell wall, the power of ultrasonic cell disruptor can be set to 600W, the frequency is set to 30kHz, the working time is set to 30min, the cavitation produced by low-frequency ultrasound is stronger, can produce larger bubble and stronger shock wave, this pre-treatment method can improve its utilization rate without destroying the main component of medicinal materials, strengthen the curative effect of pill, in ultrasonic extraction process, because temperature is relatively low, and extraction time is shorter, can effectively avoid the destruction of high temperature to the activity of effective ingredient.

[0043] Example 3: Use a rotary evaporator to reduce pressure and concentrate the filtrate. The solvent is evaporated under the dual effects of heating and reducing pressure. After the concentration is completed, stop heating and slowly restore the system to normal pressure to prevent the solution from boiling and splashing, and avoid the solute from precipitating or denaturing due to drastic changes. Then, a concentrated filtrate can be obtained. The concentrated filtrate is dried using a freeze dryer, and the dried powder is added to an airflow superfine pulverizer for pulverization. The air inlet pressure of the airflow superfine pulverizer is set to 0.6MPa, and the feed speed is set to 0.500Nm. Set it to 1kg / h, the air flow speed to 200m / s, and the crushing time to 10min, the coarse granular powder can be crushed into ultrafine powder with a particle size of 50um. The ultrafine crushing technology is used to crush the medicinal materials for resolving phlegm and dampness and dispersing nodules (such as Pinellia, Fritillaria thunbergii, etc.) into microns, which greatly increases the surface area of ​​the medicinal materials and makes the effective ingredients easier to dissolve. The effective ingredients such as Fritillaria thunbergii powder after ultrafine crushing can be absorbed by the human body faster and more fully after taking the pills, thereby improving the effect of resolving phlegm and dispersing nodules.

[0044] Example 4: Polyethylene glycol with a molecular weight of 5000 g / mol is used as a 3D printing material, the viscosity is set to 100 mPa˙s, the concentration is set to 10wt%, and a magnetic stirrer is used to stir and mix polyethylene glycol, various ultrafine powders and photoinitiators. The amount of ultrafine powder is 50% of the amount of polyethylene glycol, the amount of riboflavin photoinitiator is 3% of the amount of polyethylene glycol, the loading amount is 70% of the volume of the stirrer, the stirring speed of the stirrer is set to 1000 r / min, the temperature is set to 45°C, and the stirring time is set to 20 min. A liquid polyethylene glycol with uniform mixing and good fluidity can be obtained, which can provide better mechanical strength and stability after light curing.

[0045] Example 5. Pills are prepared using 3D printing technology, with the printing layer thickness set to 0.1 mm and the printing speed set to 25 mm / h. The accuracy and surface quality of the printed pills can be improved during printing. The internal structure and drug release pattern of the pills are designed through precise computer modeling and according to the individual differences of patients (such as the severity of phlegm and dampness, the size and location of nodules, etc.). Pills with a multi-layer structure can be designed, with the outer layer quickly releasing expectorant components to relieve symptoms, while the inner layer slowly releasing nodule-dispersing drugs to act on the lesions, thereby achieving personalized drug treatment.

[0046] As attached Figure 1 As shown, various medicinal materials are processed separately and then crushed using a rotary mill. Ultrasonic extraction technology is used to destroy the cell wall to make the components in the cell easier to release. The processed medicinal powder is crushed into ultrafine powder using ultrafine grinding technology, and a 3D printer is used to print pills of different shapes to achieve precise control of drug release.

[0047] The embodiments of the present invention are described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. For those skilled in the art, various changes, modifications, substitutions and variations of these embodiments are made without departing from the principles and spirit of the present invention, and still fall within the scope of protection of the present invention.

[0048] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0049] The above contents are merely examples and explanations of the present invention. Various modifications or additions to the specific embodiments described or replacements in similar ways by technicians in the technical field shall fall within the protection scope of the present invention as long as they do not deviate from the invention or exceed the scope defined by the claims.

[0050] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese medicine composition for removing phlegm and dampness and dispersing nodules and its preparation process, comprising washing and crushing medicinal materials for pretreatment, extracting the treated medicinal materials using ultrasonic assisted extraction technology, crushing the extracted effective ingredients into ultrafine powder using ultrafine crushing technology, mixing the ultrafine powder with 3D printing materials, and printing the medicinal materials into pills using a light-curing 3D printer, characterized in that: The specific operation steps of the Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process are as follows: Step 1: Pre-treatment of medicinal materials: remove impurities from the selected medicinal materials and wash them, and then process the medicinal materials after washing; Step 2: crushing the pretreated medicinal materials for the first time, adding the crushed medicinal materials into an ultrasonic cell disruptor, and extracting them using ultrasonic assisted extraction technology; Step 3: Using ultrafine grinding technology to grind the extracted coarse powder for a second time to grind it into ultrafine powder; Step 4: Add the crushed powder into the 3D printing material and stir evenly at a suitable temperature to form a medicine material; Step 5: Place the mixed medicine into the 3D printing device, adjust the size and type of the pills according to the patient's specific conditions, and design the most suitable pills for the individual; Step 6: Place the prepared pills in a microwave drying oven for drying. After drying, the pills are packaged using appropriate packaging materials.

2. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules according to claim 1 and its preparation process, characterized in that: In the step 1, the medicinal materials are washed to remove dirt and impurities on the surface, the washed pinellia tuber is screened, the pinellia tuber with a diameter of 1 cm-2 cm is selected, and the pinellia tuber is soaked in clean water for 48 hours to 72 hours, during which the water is changed every 12 hours, licorice is prepared according to 10% to 15% of the weight of the pinellia tuber, and 8-10 times the weight of water is added for decoction, and the decoction is performed twice, the first time is 1.5 hours to 2 hours, and the second time is 1 hour to 1.5 hours, the liquids obtained by the two decoctions are combined, lime is prepared according to 20% to 30% of the weight of the pinellia tuber, and the lime is added to water 6-10 times its own weight, and the lime milk obtained after stirring and mixing is uniformly obtained, and the lime milk is filtered to remove insoluble impurities to obtain lime liquid, and the soaked pinellia tuber is put into the licorice and lime liquid for 7 hours. The method comprises the following steps:

1. The method comprises the steps of:

1. The first step is to soak the dried tangerine peel for 2 hours and the second ...3 hours and the second step is to soak the dried tangerine peel for 3 hours and the second step is to soak the dried tangerine peel for 4 hours and the second step is to soak the dried tangerine peel for 4 hours and the second step is to soak the dried tangerine peel for 6 hours and the second step is to stir the dried tangerine peel for 6 hours and the second step is to stir the dried tangerine peel for 8 hours and the second step is to stir the dried tangerine peel for 6 hours and the second step is to stir the dried tangerine peel for 8 hours and the second step is to stir the dried tangerine peel for 6 hours and the second step is to stir the dried tangerine peel for 8 hours and the second step is to stir the dried tangerine peel for 2 hours and the second step is to stir the dried tangerine peel for 2 hours and the second step is to 3. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules according to claim 1 and its preparation process, characterized in that: In the step 1, the washed Fritillaria thunbergii is soaked in clean water for 2h-4h, the moistened Fritillaria thunbergii is cut into 3mm-5mm thick slices, a stainless steel pot is preheated to 100°C-120°C over a slow fire, the cut Fritillaria thunbergii slices are put into the stainless steel pot for frying, the frying time is 10min-15min, and when the surface of the Fritillaria thunbergii slices presents a uniform light yellow color, the frying is stopped to obtain the processed Fritillaria thunbergii, and the oyster medicinal material is soaked and cleaned, and the soaking time each time is 10min-15min. 15min, change the water 2-3 times, put the cleaned oysters evenly into the drying oven, set the temperature in the drying oven to 60℃-80℃, the drying time is 48h-72h, control the water content of the oysters between 10%-15%, use an electric calcining furnace to forge the oysters, set the temperature of the electric calcining furnace to 800℃-1000℃, and calcine for 1h-2h. After calcining, take out the oysters and place them in a dry and well-ventilated place to cool naturally. After cooling, the processed oysters are obtained.

4. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In the step 2, a high-speed rotary pulverizer is used to initially pulverize the processed medicinal material, the speed of the high-speed rotary pulverizer is set to 10000r / min-15000r / min, the pulverizing time is set to 1min-3min, the cutter is a blade type, the feed rate is set to 0.5kg / min-2kg / min, the processed dried tangerine peel and thunbergii bulb are pulverized into 40-80 mesh particles, and then the speed of the high-speed rotary pulverizer is set to 20000r / min-30000r / min, the pulverizing time is set to 5min-10min, the cutter is a hammer type cutter, and the feed rate is set to 0.5 kg / min-2kg / min, the processed French pinellia and oyster can be crushed into 80-100 mesh particles, the crushed medicinal powder is added into an ultrasonic crusher for extraction, the power of the ultrasonic cell crusher is set to 200W-600W, the frequency is set to 20kHz-100kHz, the extraction time is set to 15min-60min, the solvent is a water-ethanol mixed solvent, the mixing ratio is 30% water-70% ethanol, the temperature is set to 40℃-60℃, the ratio of the solvent volume to the medicinal material volume is 5-20:1, and after the ultrasonic extraction is completed, the extract is filtered to separate the solid residue to obtain a filtrate containing effective ingredients.

5. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In the step 2, the extracted filtrate is added to a rotary evaporator for reduced pressure concentration, the vacuum degree in the rotary evaporator is set to 1kPa-4kPa, the temperature is set to 30°C-50°C, and the rotation speed is set to 60r / min-120r / min. After the concentration is completed, the heating is stopped, and the system is slowly restored to a normal pressure state. The concentrated filtrate is taken out from the optional evaporator, and the filtrate is placed in a freezing chamber with a temperature between -20°C and 40°C for pre-freezing, and the freezing time is set to 2h-4h. After the pre-freezing is completed, the filtrate is placed in a freeze dryer, the pressure in the freeze dryer is set to 10Pa-100Pa, the temperature is set to -10°C-20°C, and the drying time is set to 12h-24h. After the drying is completed, the powder is taken out from the freeze dryer.

6. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In the step three, the coarse granular powder after extraction and drying is added into an airflow superfine pulverizer for secondary pulverization, the air intake pressure of the airflow superfine pulverizer is set to 0.4MPa-0.8MPa, the feed rate is set to 0.5kg / h-2kg / h, the air flow rate is set to 100m / s-300m / s, and the pulverization time is set to 5min-15min. During the pulverization process, samples are taken out every 2min-3min, and the particle size is detected by a laser particle size analyzer. When the particle size reaches 1-100um, the pulverization is stopped, and the coarse granular powder can be pulverized into ultrafine powder.

7. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In the step 4, polyethylene glycol is used as the 3D printing material, the molecular weight of polyethylene glycol is set to 4000g / mol-6000g / mol, the viscosity is set to 40mPa˙s-220mPa˙s, the concentration is set to 10wt%-20wt%, and the polyethylene glycol, various ultrafine powders and photoinitiators are added to a magnetic stirrer for stirring and mixing. The amount of ultrafine powder is 40%-50% of the amount of polyethylene glycol, and riboflavin is selected as the photoinitiator. The amount of riboflavin is 1%-5% of the amount of polyethylene glycol. The loading amount is 70%-80% of the volume of the stirrer, the stirring speed of the stirrer is set to 500r / min-1500r / min, the temperature is set to 30℃-60℃, and the stirring time is set to 10min-30min. After stirring and mixing, a fluid medicine can be obtained.

8. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In the step 5, the mixed medicinal material is placed in a light-curing 3D printer for printing, the wavelength of the light-curing 3D printer is set to 350nm-450nm, the printing layer thickness is set to 0.05mm-0.2mm, the printing speed is set to 10mm / h-50mm / h, and the molding platform temperature is set to 20°C-40°C. After the molded pills are printed, surface treatment is performed, and the uncured polyethylene glycol remaining on the surface of the pills is removed by a cleaning agent. The cleaning agent is selected from a 60%-70% ethanol solution, and the pills are obtained after cleaning.

9. A Chinese medicine composition for resolving phlegm and dampness and dispersing nodules and its preparation process according to claim 1, characterized in that: In step 6, the formed pills are placed in a hot air drying oven for drying. The temperature in the drying oven is set to 60°C-80°C, the drying time is set to 4h-5h, and the ventilation volume is set to 10m 3 / h-30m 3 / h, control the moisture content of the pills between 9% and 14%. After drying, place the pills in a drying box to cool naturally to room temperature, inspect the appearance of the pills directly with the naked eye, including discoloration, deformation and cracking, and use a disintegration instrument to detect the disintegration time of the pills. Pills that pass the quality inspection are then packaged using plastic bottles, and the drug name, ingredients, usage and dosage, production date and shelf life are marked on the packaging.

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