Promoter for promoting hair growth and preparation method thereof
By mixing and synthesizing a variety of Chinese medicine extracts with specific compounds, a promoter for promoting hair growth was prepared, which solved the invasiveness and high risk of side effects in existing hair loss treatment methods, and achieved a more comprehensive and effective hair growth promotion effect.
Patent Information
- Application Number
- CN202411587075.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-07
- Publication Date
- 2025-02-18
AI Technical Summary
Existing treatments for hair loss are at risk of invasive or high side effects, and the treatment effect may take months to manifest, not everyone is suitable for the effective period of existing drugs.
By ginger extract, black mulberry fruit, scutellaria baicalensis, phenoxyethanol, oxoglutaric acid, arginine, lysine, sodium hyaluronate, cypress leaf extract, ginger root extract, Polygonum multiflorum extract, The extracts of Chinese medicines such as coral algae extract are mixed with oxoglutaric acid, arginine, lysine, superoxide dismutase, yeast fermentation product extract, etc., to prepare a promoter to promote hair growth.
It provides a hair growth product with constant quality that can promote the anti-loss and growth of hair, eyelashes, and eyebrows, and provides comprehensive and effective methods for scalp conditioning, hair fixation and hair growth. The process is simple and the quality is stable.
Smart Images
Figure CN119454554A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field related to hair growth promoters, in particular to a hair growth promoter and a preparation method thereof. Background Art
[0002] There are 60,000 to 100,000 hair follicles on an adult scalp. The growth of hair follicles is cyclical and is divided into the growth phase, the regression phase, and the resting phase. During the growth phase, the hair follicles grow 0.2 to 0.4 mm per day for 2 to 7 years, and then enter the regression phase. During the regression phase, the hair follicles shrink, the hair stops growing, and it is easy to fall off, which usually lasts for 2 to 3 weeks, and then enter the resting phase. The resting phase lasts for 3 to 4 months, and the hair falls off until a new hair follicle cycle begins and enters a new growth phase. The ratio of the growth phase to the resting phase of the hair follicles on a normal human scalp is 9:1. The cause of hair loss is an increase in the proportion of resting follicles, or even atrophy of the hair follicles, which delays or prevents the growth phase. Hair follicle stem cells are an important factor in maintaining the hair follicle cycle.
[0003] Current hair loss treatments are invasive (i.e., surgery) or have a higher risk of side effects than expected. The main drugs currently used to treat androgenic alopecia are finasteride and minoxidil. Finasteride is a 4-azasteroid compound that is a specific inhibitor of the intracellular enzyme type II 5a-reductase in the process of testosterone metabolism into the more powerful dihydrotestosterone. The main therapeutic effect may not be seen until 4 months later. If it is effective, the medication should be continued, otherwise it will lead to continued hair loss. Minoxidil is classified as a potassium channel opener, which has the effect of dilating peripheral blood vessels, can reverse the regeneration of small hair follicles and accelerate hair growth, and promote the hair follicles from dormancy to regeneration. The key period to enter the growth period, using products containing minoxidil, usually after 6 to 8 weeks, you can start to see an increase in hair volume, and after 12 to 16 weeks, you can see obvious results, but not everyone is suitable for the above-mentioned effective period, sometimes you will experience an increase in hair loss first. Existing records show that minoxidil and finasteride can also delay, that is, stop or reduce the degree of hair loss, but these two drugs have certain side effects. Finasteride can inhibit male hormones and may affect normal hormone homeostasis; minoxidil has the effect of lowering blood pressure, and is not recommended for patients with low blood pressure and heart disease; in order to solve the above problems, a hair growth promoter and a preparation method thereof are proposed. Summary of the invention
[0004] In order to overcome the above problems, the present invention provides a hair growth promoter and a preparation method thereof, which solves the above problems and the like.
[0005] The present invention solves the technical problem by adopting the following technical solutions:
[0006] A hair growth promoter comprises the following raw materials in percentage by weight: 1% to 5% ginseng extract, 1% to 5% black mulberry, 1% to 5% scutellaria, 0.7% phenoxyethanol, 0.05% ethyl hydroxybenzoate, 1 to 2 parts of oxoglutaric acid, 2 to 4 parts of arginine, 0.5 to 1 part of lysine dissolved in 20 parts of water, 0.05 to 0.5 parts of sodium hyaluronate, 0.1 to 2 parts of Platycladus orientalis leaf extract, 0.5 to 2 parts of ginger root extract, 1 to 5 parts of Polygonum multiflorum extract, 0.1 to 2 parts of coral algae extract, and 0.7 parts of phenoxyethanol.
[0007] Preferably, the hair growth promoter further comprises 0.1% to 0.5% of essence, 0.5% to 15% of pigment, and 0.02% to 1% of preservative.
[0008] Preferably, the concentration of the Platycladus orientalis leaf extract is 2.5-5%.
[0009] Preferably, the concentration of the Polygonum multiflorum extract is 10%.
[0010] Preferably, the concentration of the ginger root extract is 10%.
[0011] Preferably, the concentration of the coralline algae extract is 10%.
[0012] A method for preparing a hair growth promoting agent comprises the following steps:
[0013] S1, weigh 1-2 parts of oxoglutaric acid, 2-4 parts of arginine, and 0.5-1 part of lysine, dissolve them in 20 parts of water, stir until they are completely dissolved, adjust the pH to 5.0-7.0, and set aside;
[0014] S2, add 50 parts of water to the stirring pot 11, start stirring and heating, wait until the water temperature rises to 60°C, add 0.05-0.5 parts of sodium hyaluronate, disperse evenly, and homogenize once, set the speed of the stirring paddle 18 to 5000r / min, homogenize for 1min, and set aside after fully dissolved;
[0015] S3, when the temperature in the stirring pot 11 drops to 40° C., mix the mixture in step S1 with the mixture in the stirring pot 11, and start the stirring paddle 18 to stir evenly;
[0016] S4, the Chinese medicine extracts in the extract synthesis device housing 49 are transferred to the stirring and mixing space 13 through the connecting pipe 20, and the extracts added in sequence are 0.1-2 parts of Platycladus orientalis leaf extract, 0.5-2 parts of ginger root extract, 1-5 parts of Polygonum multiflorum extract, and 0.1-2 parts of coralline algae extract, and then 0.7 parts of phenoxyethanol is added, and the stirring paddle 18 is started to stir and disperse it evenly;
[0017] S5, finally adding 1 to 6 parts of yeast fermentation product extract and 0.1 to 1 part of superoxide dismutase, and stirring to mix;
[0018] S6, the mixed solution is filtered through filter cloth to obtain the mixture.
[0019] The temperature in the above preparation process is 25-40° C., and the reaction takes 1 hour. The container is a homogenizing emulsifying pot.
[0020] The advantages and positive effects of the present invention are: a hair growth product with constant quality is produced by mixing and synthesizing a plurality of Chinese medicine extracts of certain concentrations and doses with oxoglutaric acid, arginine, lysine, superoxide dismutase, yeast fermentation product extract, sodium hyaluronate, etc., and the composition is used for preventing hair loss and promoting growth of hair, eyelashes, and eyebrows; a formula composition with functions such as scalp conditioning, hair strengthening, and hair growth promotion is provided, and a more comprehensive and effective method is provided compared to some previous products, and a suitable preparation method is provided to ensure that the process of the synthetic product is simple and the quality is stable. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] The present invention is further described below in conjunction with the accompanying drawings and embodiments.
[0022] Figure 1 This is a diagram of an experimental control group in an experimental method for a product promoting hair growth according to the present invention;
[0023] Figure 2 This is a morphological staging scoring diagram in a hair growth promoting product experimental method of the present invention;
[0024] Figure 3 A diagram showing the number of hair follicles per unit area in an experimental method for a product promoting hair growth according to the present invention; DETAILED DESCRIPTION
[0025] The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, which only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.
[0026] The embodiments of the present invention are further described in detail below with reference to the accompanying drawings:
[0027] Reference Figures 1 to 3As shown, there are 60,000 to 100,000 hair follicles on an adult scalp. The growth of hair follicles is cyclical and is divided into a growth phase, a regression phase, and a resting phase. During the growth phase, the hair follicles grow by 0.2 to 0.4 mm per day for 2 to 7 years, and then enter the regression phase. During the regression phase, the hair follicles atrophy, the hair stops growing, and becomes easy to fall out, which usually lasts for 2 to 3 weeks, and then enters the resting phase. The resting phase lasts for 3 to 4 months, and the hair falls out until a new hair follicle cycle begins and a new growth phase begins. The ratio of the growth phase to the resting phase of hair follicles on a normal human scalp is 9:1. The cause of hair loss is an increase in the proportion of resting follicles, or even atrophy of the hair follicles, which delays or makes it impossible to enter the growth phase.Hair follicle stem cells are an important factor in maintaining the hair follicle cycle; current hair loss treatments are invasive (i.e., surgery) or have a higher risk of side effects than expected. The main drugs used to treat androgenic alopecia are finasteride and minoxidil. Finasteride is a 4-azasteroid compound that is a specific inhibitor of the intracellular enzyme type II 5a-reductase in the process of testosterone metabolism into the stronger dihydrotestosterone; the main treatment effect may not be shown until 4 months later. If it is effective, the medication should be continued, otherwise it will lead to continued hair loss. Minoxidil is classified as a potassium channel opener with peripheral vasodilator The effect of tension can make tiny hair follicles produce reverse regeneration and accelerate hair growth. It is the key to promote hair follicles from the resting phase to the growth phase. When using products containing minoxidil, usually after 6 to 8 weeks, you can start to see an increase in hair volume, and after 12 to 16 weeks, you can see obvious results, but not everyone is suitable for the above-mentioned effective period. Sometimes you will experience an increase in hair loss first. It is currently recorded that minoxidil and finasteride can delay, that is, stop or reduce the degree of hair loss, but these two drugs have certain side effects. Finasteride will inhibit male hormones and may affect normal hormone homeostasis; minoxidil has The effect of lowering blood pressure is not recommended for patients with low blood pressure and heart disease. In order to solve the above problems, a hair growth promoter and its preparation method are proposed; comprising the following raw materials in percentage by weight: 1% to 5% ginseng extract, 1% to 5% black mulberry, 1% to 5% scutellaria, 0.7% phenoxyethanol, 0.05% ethyl hydroxybenzoate, 1 to 2 parts of oxoglutaric acid, 2 to 4 parts of arginine, 0.5 to 1 part of lysine dissolved in 20 parts of water, 0.05 to 0.5 parts of sodium hyaluronate, 0.1 to 2 parts of Platycladus orientalis leaf extract, 0.5 to 2 parts of ginger root extract, 1 to 5 parts of Polygonum multiflorum extract, and 0.5 to 2 parts of scutellaria baicalensis root extract. 0.1-2 parts of coral algae extract and 0.7 parts of phenoxyethanol; a hair growth product with constant quality is produced by mixing and synthesizing a plurality of Chinese medicine extracts of a certain concentration and dosage with oxoglutaric acid, arginine, lysine, superoxide dismutase, yeast fermentation product extract, sodium hyaluronate, etc., and the composition is used for preventing hair loss and promoting growth of hair, eyelashes, and eyebrows; a formula composition with functions such as scalp conditioning, hair strengthening, and hair growth promotion is provided, which provides a more comprehensive and effective method compared with some previous products, and provides a suitable preparation method to ensure that the process of the synthetic product is simple and the quality is stable.
[0028] The temperature in the above preparation process is 25-40° C., and the reaction takes 1 hour. The container is a homogenizing emulsifying pot.
[0029] It should be noted that the hair growth promoter also includes 0.1% to 0.5% flavor, 0.5% to 15% pigment, and 0.02% to 1% preservative; L-carnitine helps maintain cellular energy metabolism and assists fat transport through the cell membrane into the mitochondria in the cell, where fat is oxidized to produce cellular energy ATP, so it can increase the energy supply of hair follicles, help hair follicle cell proliferation, and maintain hair follicles in the growth phase.
[0030] Furthermore, hair keratin is one of the fiber structural protein family, which is the key structural material of hair. Hair keratin amino acids provide raw materials for the growth of hair in hair follicles; and raspberry ketone is the main aromatic compound contained in raspberries, which can activate sensory neurons to increase the production of IGF-I in the skin to increase skin elasticity and promote hair growth.
[0031] Sodium hyaluronate, also known as sodium hyaluronate, is the sodium salt of hyaluronic acid. As a glycosaminoglycan, sodium hyaluronate exists in the extracellular matrix of connective tissues in many parts of the human body and in the cornea. It is composed of D-glucuronic acid and N-acetyl-D-glucosamine. It can improve the skin's water retention effect and nourish the scalp to nourish, care for and prevent hair loss.
[0032] Dexpanthenol, also known as provitamin B5, is widely used in medicine, food, cosmetics and liquid preparations. D-panthenol can be converted into pantothenic acid when entering the human body, and then synthesize coenzyme A, promoting the metabolism of protein, fat and sugar in the human body, protecting the skin and mucous membranes, promoting hair growth, keeping hair moisturized, reducing split ends, preventing dryness and breakage, and protecting, repairing and caring for hair.
[0033] Yeast glucan can repair mucous membranes and has moisturizing, hair growth, anti-oxidation and other effects.
[0034] Niacinamide is the amide of niacin (vitamin B3), a water-soluble vitamin and a member of the vitamin B family. It can improve blood circulation in the scalp and promote the absorption of nutrients by hair follicles.
[0035] Experiment 1: Using a hair growth promoting product prepared by a hair growth promoting product preparation method, a hair growth effect test on mice is carried out, comprising the following steps:
[0036] 1. Experimental animals: C57BL6 mice, 7 weeks old, about 20 g, SPF grade, 40 mice in total.
[0037] 2. Experimental grouping: The mice were first subjected to adaptive feeding for one week, during which they were free to eat and drink. After the adaptation period, 40 mice were randomly divided into a normal group, a model group, an experimental group, and a positive control group, with 10 mice in each group.
[0038] 3. Test steps:
[0039] (1) Model building
[0040] On the first day, mice were anesthetized with ether, and equal amounts of paraffin and rosin were mixed, heated and melted, and then applied to the back of the mice. After solidification and hardening, the hair was removed.
[0041] (2) Drug administration
[0042] On the second day, 200 μL of 0.05% testosterone was applied to the depilated areas of mice in the model group, experimental group, and positive control group. After 1 hour of treatment, 200 μL of conditioning solution and 2% finasteride solution were applied to the experimental group and positive control group, respectively. The normal group and model group were given an equal volume of deionized water. The whole process was once a day for 28 consecutive days.
[0043] (3) Observe hair growth
[0044] The hair growth of the depilated area of each group of mice was observed every day, and the changes in skin color were recorded to evaluate the effects of the conditioning solution and the positive control drug on the hair growth of mice. Starting from the 7th day, the length of the new hair was measured.
[0045] 4. Results
[0046] (1) Skin discoloration and hair germination time
[0047]
[0048] (Compared with the normal group, *p<0.05, **p<0.01; compared with the model group #p<0.05, ##p<0.01)
[0050] (2) Hair follicle morphology staging score and growth status.
[0051] The mouse hair follicles were scored according to the Muller-Rover hair follicle morphology stage. The normal group scored 130.20 points, indicating that the hair follicles were in the IV substage and early stage of regression; the model group scored 315.49 points, indicating that most hair follicles were in the middle and late stages of regression; the positive control group scored 161.75 points, indicating that most hair follicles were in the growth stage; the hair growth solution group scored 148.98 points, indicating that the hair growth solution can inhibit the hair follicles from entering the regression stage and resting stage.
[0052] By observing the number of hair follicles per unit area, it can be found that the hair follicle density per unit area in the model group is significantly lower than that in the normal group, while the hair follicle density per unit area in the positive control group and the hair growth solution group is significantly higher than that in the model group. This result also shows that the patented hair growth solution group has a promoting effect on the hair follicles entering the growth phase.
[0053]
[0054] (Compared with the normal group, *p<0.05, **p<0.01; compared with the model group #p<0.05, ##p<0.01).
[0055] A hair growth product with constant quality is produced by mixing a variety of Chinese herbal extracts of certain concentrations and doses with oxoglutaric acid, arginine, lysine, superoxide dismutase, yeast fermentation product extract, sodium hyaluronate, etc. The composition is used for preventing hair loss and promoting growth of hair, eyelashes, and eyebrows.
[0056] It should be emphasized that the embodiments described in the present invention are illustrative rather than restrictive, and therefore the present invention is not limited to the embodiments described in the specific implementation manners. Any other implementation manners derived by those skilled in the art based on the technical solutions of the present invention also fall within the scope of protection of the present invention.
Claims
1. A hair growth promoter, characterized in that: The invention comprises the following raw materials in percentage by weight: 1% to 5% ginseng extract, 1% to 5% black mulberry, 1% to 5% scutellaria baicalensis, 0.7% phenoxyethanol, 0.05% ethyl hydroxybenzoate, 1 to 2 parts of oxoglutaric acid, 2 to 4 parts of arginine, 0.5 to 1 part of lysine dissolved in 20 parts of water, 0.05 to 0.5 parts of sodium hyaluronate, 0.1 to 2 parts of Platycladus orientalis leaf extract, 0.5 to 2 parts of ginger root extract, 1 to 5 parts of Polygonum multiflorum extract, 0.1 to 2 parts of coral algae extract and 0.7 parts of phenoxyethanol.
2. The hair growth promoting agent according to claim 1, characterized in that: The hair growth promoter also includes 0.1% to 0.5% of essence, 0.5% to 15% of pigment, and 0.02% to 1% of preservative.
3. The hair growth promoting agent according to claim 1, characterized in that: The concentration of the Platycladus orientalis leaf extract is 2.5-5%.
4. The hair growth promoting agent according to claim 1, characterized in that: The concentration of the Polygonum multiflorum extract is 10%.
5. The hair growth promoting agent according to claim 1, characterized in that: The concentration of the ginger root extract is 10%.
6. The hair growth promoting agent according to claim 1, characterized in that: The concentration of the coral algae extract is 10%.
7. The method for preparing a hair growth promoter according to claim 1, characterized in that: The steps include: S1, weigh 1-2 parts of oxoglutaric acid, 2-4 parts of arginine, and 0.5-1 part of lysine, dissolve them in 20 parts of water, stir until they are completely dissolved, adjust the pH to 5.0-7.0, and set aside; S2, add 50 parts of water to the stirring pot 11, start stirring and heating, wait until the water temperature rises to 60°C, add 0.05-0.5 parts of sodium hyaluronate, disperse evenly, and homogenize once, set the speed of the stirring paddle 18 to 5000r / min, homogenize for 1min, and set aside after fully dissolved; S3, when the temperature in the stirring pot 11 drops to 40° C., mix the mixture in step S1 with the mixture in the stirring pot 11, and start the stirring paddle 18 to stir evenly; S4, the Chinese medicine extracts in the extract synthesis device housing 49 are transferred to the stirring and mixing space 13 through the connecting pipe 20, and the extracts added in sequence are 0.1-2 parts of Platycladus orientalis leaf extract, 0.5-2 parts of ginger root extract, 1-5 parts of Polygonum multiflorum extract, and 0.1-2 parts of coralline algae extract, and then 0.7 parts of phenoxyethanol is added, and the stirring paddle 18 is started to stir and disperse it evenly; S5, finally adding 1 to 6 parts of yeast fermentation product extract and 0.1 to 1 part of superoxide dismutase, and stirring to mix; S6, the mixed solution is filtered through filter cloth to obtain the mixture.
8. The method for preparing a hair growth promoting agent according to claim 7, characterized in that: The temperature in the above preparation process is 25-40° C., and the reaction takes 1 hour. The container is a homogenizing emulsifying pot.