Moxibustion paste and preparation method thereof

Abstract

The invention provides moxibustion paste and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, the moxibustion paste comprises traditional Chinese medicine composition clear paste and a matrix, the traditional Chinese medicine composition clear paste is prepared from, by mass, 20-30 parts of folium artemisiae argyi, 10-20 parts of radix scutellariae, 10-20 parts of rhizoma coptidis, 10-20 parts of cortex phellodendri, 15-25 parts of fructus forsythiae, 10-20 parts of rhizoma polygoni cuspidati and 5-10 parts of radix salviae miltiorrhizae; the matrix comprises 3-5 parts of wormwood oil, 10-15 parts of beewax and 5-14 parts of auxiliary materials. The folium artemisiae argyi, the radix scutellariae, the rhizoma coptidis, the cortex phellodendri and the like are adopted for preparing the moxibustion cream, the folium artemisiae argyi, the radix scutellariae, the rhizoma coptidis and the like have the effects of diminishing inflammation and sterilizing the acne and the nearby skin, and the cortex phellodendri is used for eliminating inflammation edema of the acne and the nearby skin, promoting granulation tissue generation and accelerating recovery of the skin nearby the acne; the components such as beewax in the moxibustion cream can deeply clean grease in hair follicles, and acne recurrence is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a moxibustion cream and a preparation method thereof. Background Art

[0002] Moxibustion paste is a paste made by extracting a variety of herbs, blending beeswax and then boiling it through a special process. When used, it is heated to a certain temperature and applied to the part of the human body that needs hot moxibustion. The heat uses the body's pores to quickly open the effective ingredients in the moxibustion paste to penetrate deep into the subcutaneous tissue, which can relieve symptoms such as muscle and bone pain, numbness of the limbs, and heaviness in the waist and back.

[0003] At present, many people are prone to acne on their backs, especially teenagers, whose androgen levels increase during puberty, leading to increased sebum secretion on the back skin. If it is not cleaned in time, acne may form. Excessive sebum on the patient's skin will lead to the massive growth and reproduction of Propionibacterium acnes in the hair follicles and sebaceous glands, and will also damage the hair follicle tissue, causing an inflammatory reaction around the hair follicles, causing acne on the back. If the inflammation spreads, it will cause the condition to worsen. At present, drugs such as retinoic acid cream and adapalene gel are usually used for treatment, but the effect is not obvious and it is easy to relapse. Summary of the invention

[0004] In view of the technical problems existing in the background technology, the present application provides a moxibustion ointment and a preparation method thereof, aiming to solve the technical problem that back acne is difficult to cure and prone to recurrence.

[0005] In the first aspect, an embodiment of the present application provides a moxibustion paste, including a Chinese medicine composition paste and a matrix. The Chinese medicine composition paste is prepared from 20 to 30 parts of mugwort, 10 to 20 parts of scutellaria, 10 to 20 parts of coptis, 10 to 20 parts of phellodendron, 15 to 25 parts of forsythia, 10 to 20 parts of knotweed and 5 to 10 parts of salvia miltiorrhiza, by weight; the matrix includes 3 to 5 parts of mugwort oil, 10 to 15 parts of beeswax and 5 to 14 parts of auxiliary materials.

[0006] Preferably, the auxiliary materials include honey, wintergreen oil, glycerin and borneol, wherein the mass ratio of honey, wintergreen oil, glycerin and borneol is (1-5):(1-3):(2-3):(1-3).

[0007] Preferably, the matrix also includes far-infrared ceramic powder, and the mass ratio of the far-infrared ceramic powder to the wormwood oil is (8-10): (3-5).

[0008] In a second aspect, the present application provides a method for preparing a moxibustion cream, comprising the following steps: S1. Take the Chinese medicine composition according to the mass fraction, make it into powder, and mix it evenly to obtain a mixture; S2, soaking the mixture in clean water for 30-60 min, and then distilling it using steam distillation to obtain fractions and substrates; S3, concentrate the substrate under reduced pressure, then add 8 to 12 times the volume of the substrate in ethanol solution for alcohol precipitation for 24 to 48 hours; S4, filtering after the alcohol precipitation to separate the supernatant from the impurities, and concentrating the supernatant to obtain a clear paste; S5. Evenly mix the clear paste and the base and stir them into a paste to obtain the moxibustion paste.

[0009] Preferably, ultrasonic treatment is performed for 5 to 10 seconds every 5 minutes during the immersion in step S2.

[0010] Preferably, the concentration of the ethanol solution in step S4 is 80% to 90%.

[0011] Preferably, the method for preparing wormwood oil in a matrix comprises the following steps: (1) After crushing the mugwort, soak it in alkaline solution for 45-60 minutes, then heat the solution to boiling, keep it warm for 60-90 seconds, and filter to obtain the precipitate; (2) washing the precipitate with clean water until the pH value is between 8.5 and 9.5, and then hydrolyzing the precipitate with a composite enzyme to obtain a mixture of the hydrolyzed precipitate and the composite enzyme solution; (3) After adding water to the blend, the mixture is extracted by steam distillation to obtain mugwort oil.

[0012] Preferably, the alkali solution in step (1) is a sodium hydroxide aqueous solution with a mass fraction of 15%.

[0013] Preferably, the complex enzyme comprises at least two of alkaline protease, cellulase, hemicellulase and pectinase.

[0014] Preferably, in step (2), the enzymolysis temperature is 35-40°C, and the enzymolysis time is 200-220 min.

[0015] Different from the existing technical solutions, the beneficial effects of this application include: 1. This application uses wormwood, scutellaria, coptis, phellodendron and other ingredients to prepare moxibustion paste. wormwood has the effects of dispelling cold and relieving pain, warming the meridians and stopping bleeding, and disinfecting and sterilizing; coptis contains berberine, which has the effects of anti-inflammatory, sterilization and anti-ulcer; the flavonoids in scutellaria have inhibitory effects on a variety of viruses, bacteria and fungi, and phellodendron has the effect of reducing swelling. This application uses a variety of Chinese herbal medicines for compound use, combined with hot moxibustion applied to the patient's back, which can soften the hair follicles under the action of heat and allow the drug ingredients to penetrate into the hair follicles. Drugs such as wormwood, scutellaria, and coptis have anti-inflammatory and sterilizing effects on acne and nearby skin, and phellodendron eliminates inflammatory edema in acne and nearby skin, promotes granulation tissue formation, and accelerates the recovery of skin near acne; ingredients such as beeswax in the moxibustion paste can deeply clean the oil inside the hair follicles to avoid recurrence of acne.

[0016] 2. The matrix of the present application is blended with wormwood oil. After the wormwood oil is enzymatically hydrolyzed by wormwood, it is extracted by steam distillation to fully extract the effective substances in wormwood. By utilizing the volatility of wormwood oil, the wormwood oil can penetrate deeply into the deep layers of the skin during the hot moxibustion process, and has the effect of improving skin redness and itching.

[0017] 3. The matrix of the present application also includes far-infrared ceramic powder, which can radiate more far-infrared rays, activate the activity of biological macromolecules such as nucleic acid proteins, thereby enhancing the phagocytic function of white blood cells and reticuloendothelial cells, and achieve the purpose of anti-inflammatory and antibacterial. After the far-infrared of the far-infrared ceramic powder acts on the skin, most of the energy is absorbed by the skin, and the absorbed energy is converted into heat energy, causing the skin temperature to rise, dilating blood vessels, accelerating blood circulation, and enhancing metabolism.

[0018] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. DETAILED DESCRIPTION

[0019] The following is a detailed description of the embodiments of the technical solution of the present application. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which this application belongs; the terms used herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" in the specification and claims of this application and the above description and any variations thereof are intended to cover non-exclusive inclusions.

[0021] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0022] In the description of the embodiments of the present application, the term "multiple" refers to more than two (including two). Similarly, "multiple groups" refers to more than two groups (including two groups), and "multiple pieces" refers to more than two pieces (including two pieces).

[0023] Currently, back acne is usually treated with drugs such as tretinoin cream and adapalene gel, but the effect is not obvious and it is easy to recur.

[0024] In order to solve the technical problem that back acne is difficult to cure and prone to recurrence, the present application provides a moxibustion ointment and a preparation method thereof, wherein the present application uses ingredients such as wormwood, scutellaria, coptis, and phellodendron to prepare the moxibustion ointment. wormwood, scutellaria, coptis, and other drugs have anti-inflammatory and bactericidal effects on acne and nearby skin. Phellodendron eliminates inflammatory edema of acne and nearby skin, promotes the formation of granulation tissue, and accelerates the recovery of skin near acne. Ingredients such as beeswax in the ointment can deeply clean the oil inside the hair follicles to avoid recurrence of acne.

[0025] In the first aspect, an embodiment of the present application provides a moxibustion paste, including a Chinese medicine composition paste and a matrix. The Chinese medicine composition paste is prepared from 20 to 30 parts of mugwort, 10 to 20 parts of scutellaria, 10 to 20 parts of coptis, 10 to 20 parts of phellodendron, 15 to 25 parts of forsythia, 10 to 20 parts of knotweed and 5 to 10 parts of salvia miltiorrhiza, by weight; the matrix includes 3 to 5 parts of mugwort oil, 10 to 15 parts of beeswax and 5 to 14 parts of auxiliary materials.

[0026] In the technical scheme of the embodiment of the present application, wormwood leaf has the effects of dispelling cold and relieving pain, warming the meridians and stopping bleeding, and disinfecting and sterilizing; berberine is contained in coptis root, which has the effects of anti-inflammatory and sterilizing, and anti-ulcer; the flavonoids in scutellaria have inhibitory effects on a variety of viruses, bacteria and fungi, and phellodendron has the effect of reducing swelling. The present application adopts a variety of Chinese herbal medicines for compound use, combined with hot moxibustion applied to the patient's back, which can soften the hair follicles under the action of heat, so that the drug ingredients can penetrate into the hair follicles, and wormwood leaf, scutellaria, coptis root and other drugs have the effects of anti-inflammatory and sterilization on acne and nearby skin, and phellodendron eliminates inflammatory edema of acne and nearby skin, promotes granulation tissue formation, and accelerates the recovery of skin near acne; ingredients such as beeswax in moxibustion cream can deeply clean the oil inside the hair follicles to avoid recurrence of acne; using the volatility of wormwood oil, wormwood oil can penetrate deeply into the deep layer of the skin during hot moxibustion, which has the effect of improving skin redness and itching.

[0027] Preferably, the auxiliary materials include honey, wintergreen oil, glycerin and borneol, wherein the mass ratio of honey, wintergreen oil, glycerin and borneol is (1-5):(1-3):(2-3):(1-3).

[0028] Preferably, the matrix also includes far-infrared ceramic powder, and the mass ratio of the far-infrared ceramic powder to the wormwood oil is (8-10): (3-5).

[0029] In the technical solution of the embodiment of the present application, the far-infrared ceramic powder can radiate more far-infrared rays, which can activate the activity of biological macromolecules such as nucleic acid proteins, thereby enhancing the phagocytic function of white blood cells and reticuloendothelial cells, achieving the purpose of anti-inflammatory and antibacterial. After the far-infrared of the far-infrared ceramic powder acts on the skin, most of the energy is absorbed by the skin, and the absorbed energy is converted into heat energy, causing the skin temperature to rise, blood vessels to dilate, blood circulation to accelerate, and metabolism to enhance.

[0030] In a second aspect, the present application provides a method for preparing a moxibustion cream, comprising the following steps: S1. Take the Chinese medicine composition according to the mass fraction, make it into powder, and mix it evenly to obtain a mixture; S2, soaking the mixture in clean water for 30-60 min, and then distilling it using steam distillation to obtain fractions and substrates; S3, concentrate the substrate under reduced pressure, then add 8 to 12 times the volume of the substrate in ethanol solution for alcohol precipitation for 24 to 48 hours; S4, filtering after the alcohol precipitation to separate the supernatant from the impurities, and concentrating the supernatant to obtain a clear paste; S5. Evenly mix the clear paste and the base and stir them into a paste to obtain the moxibustion paste.

[0031] Preferably, ultrasonic treatment is performed for 5 to 10 seconds every 5 minutes during the immersion in step S2.

[0032] Preferably, the concentration of the ethanol solution in step S4 is 80% to 90%.

[0033] Preferably, the method for preparing wormwood oil in a matrix comprises the following steps: (1) After crushing the mugwort, soak it in alkaline solution for 45-60 minutes, then heat the solution to boiling, keep it warm for 60-90 seconds, and filter to obtain the precipitate; (2) washing the precipitate with clean water until the pH value is between 8.5 and 9.5, and then hydrolyzing the precipitate with a composite enzyme to obtain a mixture of the hydrolyzed precipitate and the composite enzyme solution; (3) After adding water to the blend, the mixture is extracted by steam distillation to obtain mugwort oil.

[0034] Preferably, the alkali solution in step (1) is a sodium hydroxide aqueous solution with a mass fraction of 15%.

[0035] Preferably, the complex enzyme comprises at least two of alkaline protease, cellulase, hemicellulase and pectinase.

[0036] Preferably, in step (2), the enzymolysis temperature is 35-40°C, and the enzymolysis time is 200-220 min.

[0037] Some specific embodiments are listed below. It should be noted that the embodiments described below are exemplary and are only used to explain the present application, and should not be construed as limiting the present application. If specific techniques or conditions are not specified in the embodiments, the techniques or conditions described in the literature in this area or the product specifications are used. The reagents or instruments used without specifying the manufacturer are all conventional products that can be obtained commercially.

[0038] 1. Preparation method Example 1 A method for preparing moxibustion cream comprises the following steps: S1. Take a Chinese medicine composition by mass, including 20 parts of Artemisia argyi, 20 parts of Scutellaria baicalensis, 10 parts of Coptis chinensis, 20 parts of Phellodendron chinense, 15 parts of Forsythia suspensa, 20 parts of Polygonum cuspidatum and 5 parts of Salvia miltiorrhiza, make them into powder, and mix them evenly to obtain a mixture; S2, soaking the mixture in clean water for 60 minutes, using ultrasonic treatment for 5 seconds every 5 minutes during the soaking period, and then distilling it using steam distillation to obtain fractions and substrates; S3, concentrate the substrate under reduced pressure, then add 12 times the volume of the substrate to ethanol solution for precipitation for 24 hours, the concentration of the ethanol solution is 90%; S4, filtering after the alcohol precipitation to separate the supernatant from the impurities, and concentrating the supernatant to obtain a clear paste; S5. Mix the clear paste and the base, including 1 part of honey, 15 parts of beeswax, 1 part of wintergreen oil, 3 parts of glycerin, 1 part of borneol, 5 parts of wormwood oil and 8 parts of far-infrared ceramic powder, and stir them into a paste to obtain moxibustion paste.

[0039] The preparation method of wormwood oil comprises the following steps: (1) After crushing the mugwort, soak it in a 15% sodium hydroxide aqueous solution for 45 minutes, then heat the solution to boiling, keep it warm for 90 seconds, and filter to obtain the precipitate; (2) washing the precipitate with clean water until the pH value is between 8.5, and then enzymolyzing the precipitate with alkaline protease and cellulase at a hydrolysis temperature of 40° C. for 220 min to obtain a blend of the precipitate and the complex enzyme solution after enzymolysis; (3) After adding water to the blend, the mixture is extracted by steam distillation to obtain mugwort oil.

[0040] Example 2 A method for preparing moxibustion cream comprises the following steps: S1. Take a Chinese medicine composition by mass, including 30 parts of Artemisia argyi, 10 parts of Scutellaria baicalensis, 20 parts of Coptis chinensis, 10 parts of Phellodendron chinense, 25 parts of Forsythia suspensa, 10 parts of Polygonum cuspidatum and 10 parts of Salvia miltiorrhiza, make them into powder, and mix them evenly to obtain a mixture; S2, soaking the mixture in clean water for 30 minutes, using ultrasonic treatment for 10 seconds every 5 minutes during the soaking period, and then distilling it using steam distillation to obtain fractions and substrates; S3, concentrate the substrate under reduced pressure, then add 8 times the volume of the substrate to ethanol solution for precipitation for 48 hours, the concentration of the ethanol solution is 80%; S4, filtering after the alcohol precipitation to separate the supernatant from the impurities, and concentrating the supernatant to obtain a clear paste; S5. Mix the clear paste and the base, including 5 parts of honey, 10 parts of beeswax, 3 parts of wintergreen oil, 2 parts of glycerin, 3 parts of borneol, 3 parts of wormwood oil and 10 parts of far-infrared ceramic powder, and stir them into a paste to obtain moxibustion paste.

[0041] The preparation method of wormwood oil comprises the following steps: (1) After crushing the mugwort, soak it in a 15% sodium hydroxide aqueous solution for 45 minutes, then heat the solution to boiling, keep it warm for 90 seconds, and filter to obtain the precipitate; (2) washing the precipitate with clean water until the pH value is between 8.5, and then enzymolyzing the precipitate with alkaline protease, cellulase, hemicellulase and pectinase at a hydrolysis temperature of 40° C. for 200 min to obtain a blend of the hydrolyzed precipitate and a composite enzyme solution; (3) After adding water to the blend, the mixture is extracted by steam distillation to obtain mugwort oil.

[0042] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that no wormwood oil is added.

[0043] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that no far-infrared ceramic powder is added.

[0044] 2. Test Method Moxibustion cream effect detection method: Forty healthy subjects aged 18 to 40 years old with acne on the back, acne grade 2, and pustular acne on the back were selected.

[0045] After cleaning the back, wait until the skin is dry, heat the moxibustion cream to 35-40℃, apply it to the subject's back with a thickness of 0.3-0.8cm, apply it for 60min, gently remove the moxibustion cream, and apply moxibustion once a day for 7 consecutive times.

[0046] The image analysis system Visia-CR was used; test parameters: skin color (red-green) value a× value, erythema area percentage; test time points D0 / D3 / D7; test site: back; parameter description: the smaller the a× value, the milder the acne redness; the smaller the erythema area percentage, the smaller the acne redness area.

[0047] III. Analysis of test results of various embodiments and comparative examples The moxibustion cream prepared by the methods of Examples 1 and 2 and Comparative Examples 1 and 2 and Beijing Tong Ren Tang moxibustion mud paste were used as Comparative Example 3 to test the effect of moxibustion cream on subjects. The number of subjects for each moxibustion cream was 10. The skin color (red-green) value a× value and the proportion of erythema area of ​​the acne site detected were averaged from the 10 subjects to obtain the test data. The test data of each embodiment and comparative example on D0, D3 and D7 days are shown in Table 1.

[0048] Table 1 Statistics of skin color (red-green) value a× value and erythema area ratio

[0049] From the data in Table 1, it can be seen that the moxibustion cream prepared by the method of the present application has a good therapeutic effect on back acne. After 7 days of treatment, the color of acne was significantly lightened, and the area of ​​erythema was reduced by about 70%. The effects in Comparative Examples 1 and 2 are slightly worse than those in Example 1, indicating that during the hot moxibustion process, wormwood oil can penetrate deeply into the deep layers of the skin, and has the effect of improving skin redness and itching; far-infrared ceramic powder can radiate more far-infrared rays, which can activate the activity of biological macromolecules such as nucleic acid proteins, thereby enhancing the phagocytic function of white blood cells and reticuloendothelial cells, achieving the purpose of anti-inflammatory and antibacterial.

[0050] The commercially available Tong Ren Tang moxibustion mud paste in Comparative Example 3 was used for the test. The skin color and erythema area of ​​the test subjects did not change significantly before and after, indicating that conventional moxibustion pastes cannot achieve the technical effect of the present application for treating back acne.

[0051] It should be noted that the present application is not limited to the above-mentioned embodiments. The above-mentioned embodiments are only examples, and the embodiments having the same structure as the technical idea and exerting the same effect within the scope of the technical solution of the present application are all included in the technical scope of the present application. In addition, without departing from the scope of the main purpose of the present application, various modifications that can be thought of by those skilled in the art to the embodiments and other methods of combining some of the constituent elements in the embodiments are also included in the scope of the present application.

Claims

1. A moxibustion cream, characterized in that: The invention comprises a Chinese medicine composition paste and a matrix, wherein the Chinese medicine composition paste is prepared from 20-30 parts of wormwood leaf, 10-20 parts of scutellaria baicalensis, 10-20 parts of coptis root, 10-20 parts of phellodendron amurense, 15-25 parts of forsythia suspensa, 10-20 parts of knotweed and 5-10 parts of salvia miltiorrhiza; the matrix comprises 3-5 parts of wormwood oil, 10-15 parts of beeswax and 5-14 parts of auxiliary materials.

2. A moxibustion cream according to claim 1, characterized in that: The auxiliary materials include honey, wintergreen oil, glycerin and borneol, wherein the mass ratio of honey, wintergreen oil, glycerin and borneol is (1-5):(1-3):(2-3):(1-3).

3. A moxibustion cream according to claim 1, characterized in that: The matrix also includes far-infrared ceramic powder, and the mass ratio of the far-infrared ceramic powder to wormwood oil is (8-10): (3-5).

4. The method for preparing a moxibustion cream according to any one of claims 1 to 3, wherein: The steps include: S1. Take the Chinese medicine composition according to the mass fraction, make it into powder, and mix it evenly to obtain a mixture; S2, soaking the mixture in clean water for 30-60 min, and then distilling it using steam distillation to obtain fractions and substrates; S3, concentrate the substrate under reduced pressure, then add 8 to 12 times the volume of the substrate in ethanol solution for alcohol precipitation for 24 to 48 hours; S4, filtering after the alcohol precipitation to separate the supernatant from the impurities, and concentrating the supernatant to obtain a clear paste; S5. Evenly mix the clear paste and the base and stir them into a paste to obtain the moxibustion paste.

5. The method for preparing a moxibustion cream according to claim 4, characterized in that: During the immersion in step S2, ultrasonic treatment is performed for 5 to 10 seconds every 5 minutes.

6. The method for preparing a moxibustion cream according to claim 4, characterized in that: The concentration of the ethanol solution in step S4 is 80% to 90%.

7. The method for preparing a moxibustion cream according to claim 4, characterized in that: The preparation method of wormwood oil in the matrix comprises the following steps: (1) After crushing the mugwort, soak it in alkaline solution for 45-60 minutes, then heat the solution to boiling, keep it warm for 60-90 seconds, and filter to obtain the precipitate; (2) washing the precipitate with clean water until the pH value is between 8.5 and 9.5, and then hydrolyzing the precipitate with a composite enzyme to obtain a blend of a hydrolyzed precipitate and a composite enzyme solution; (3) After adding water to the blend, the mixture is extracted by steam distillation to obtain mugwort oil.

8. The method for preparing a moxibustion cream according to claim 7, characterized in that: The alkali solution in step (1) is a sodium hydroxide aqueous solution with a mass fraction of 15%.

9. The method for preparing a moxibustion cream according to claim 7, characterized in that: The complex enzyme comprises at least two of alkaline protease, cellulase, hemicellulase and pectinase.

10. The method for preparing a moxibustion cream according to claim 7, characterized in that: In the step (2), the enzymolysis temperature is 35-40°C and the enzymolysis time is 200-220 min.

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