Traditional Chinese medicine weight-losing and digestion-promoting pill and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine weight-losing and digestion-promoting pill and a preparation method thereof, and relates to the technical field of medicines and health-care foods. The preparation method comprises the following steps: firstly, extracting effective active ingredients of silverweed cinquefoil root and rhizoma polygonati by using a hot water / ethanol extraction method to prepare silverweed cinquefoil root powder and rhizoma polygonati polysaccharide powder; extracting volatile oil and water-insoluble components in Pu'er tea, lotus leaves, coix seeds and dried orange peel by using a carbon dioxide supercritical extraction method to obtain a mixed medicinal material extract and mixed medicinal material residues; adding water into hawthorn, sophora flower, medicated leaven stir-fried with bran, dark malt and the mixed medicinal material residues, decocting twice, combining filtrates, centrifuging, concentrating, drying and crushing to obtain medicinal material fine powder; mixing the silverweed cinquefoil root powder, the rhizoma polygonati polysaccharide powder, the endothelium corneum gigeriae galli-poria cocos powder, the medicinal material fine powder and the mixed medicinal material extract, and adding refined honey to prepare the traditional Chinese medicine weight-losing and digestion-promoting pill The traditional Chinese medicine weight-losing and digestion-promoting pill prepared by the invention has the effects of promoting digestion, relieving stasis, losing weight, lowering lipid, tonifying spleen and promoting diuresis.

Description

Technical Field

[0001] The invention relates to the technical field of medicine and health food, in particular to a traditional Chinese medicine weight loss and digestion pill and a preparation method thereof. Background Art

[0002] With the improvement of people's living standards and the change of lifestyle, the number of obese people has increased significantly. Obesity is a globally prevalent independent chronic disease characterized by excessive accumulation of body fat. It not only affects people's appearance, but also is closely related to many chronic diseases such as diabetes, hypertension, cardiovascular and cerebrovascular diseases. The problem of obesity has an obvious impact on people's physical and mental health. The most common methods of weight loss are dieting and exercise. For obese people who still find it difficult to achieve the ideal weight loss effect through diet and exercise, drug therapy is also a common way to lose weight. While Western medicine for weight loss continues to have obvious side effects that discourage people, Chinese medicine for weight loss is highly respected. Summary of the invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine weight loss and digestion pill and a preparation method thereof, so as to solve the problems existing in the prior art.

[0004] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0005] A Chinese medicine weight loss and digestion pill, which is prepared by mixing bracken powder, polygonatum polysaccharide powder, chicken gizzard lining-poria powder, medicinal material powder, mixed medicinal material extract, and refined honey;

[0006] The bracken anserine powder and polygonatum sibiricum polysaccharide powder are prepared by extracting bracken anserine and polygonatum sibiricum with hot water / ethanol;

[0007] The mixed medicinal material extract is prepared by extracting Pu'er tea, lotus leaf, coix seed and tangerine peel by supercritical carbon dioxide extraction;

[0008] The medicinal material fine powder is prepared by boiling hawthorn, sophora japonica flower, bran-fried Shenqu, scorched malt and mixed medicinal material residues in water twice, combining the filtrate, centrifuging, concentrating, drying and pulverizing.

[0009] As an optimization, the mixed medicinal material residue is the residue left after the mixed medicinal material extract is extracted from the formulated amount of Pu'er tea, lotus leaf, coix seed and tangerine peel by supercritical carbon dioxide extraction method.

[0010] As an optimization, the chicken gizzard lining-Poria cocos powder is obtained by mixing chicken gizzard lining and Poria cocos and then drying and crushing them.

[0011] As an optimization, the formula of the Chinese medicine weight loss and digestion pills is, by mass, 10 to 12 parts of Pu'er tea, 6 to 8 parts of hawthorn, 2 to 3 parts of bracken, 2 to 3 parts of polygonatum, 6 to 7 parts of poria, 3 to 4 parts of coix seeds, 2 to 3 parts of sophora japonica, 4 to 7 parts of tangerine peel, 8 to 10 parts of fried Shenqu with bran, 1 to 2 parts of chicken gizzard lining, 3 to 4 parts of scorched malt, 4 to 6 parts of lotus leaves, and 1 to 1.5 parts of Achyranthes bidentata.

[0012] A method for preparing a Chinese medicine weight loss and digestion pill comprises the following steps:

[0013] (1) Mix the chicken's gizzard lining and Poria cocos in a formula amount, dry at 45-50° C. to constant weight, grind using a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0014] (2) According to the mass ratio, 1 part of Potentilla anserina and 4-5 parts of pure water were mixed evenly, and the mixture was placed in a water bath at 55-65° C. and 100-200 r / min for 46-50 h, filtered, and the filtrate was centrifuged at 4000-5000 rpm for 10-12 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 10-14 h, and centrifuged at 5000-6000 rpm for 12-15 min. The supernatant was concentrated under reduced pressure at 55-65° C. to 1 / 10 of the original volume, and vacuum dried at 50-60° C. for 14-16 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0015] (3) According to the mass fraction, 1 part of polygonatum and 9-11 parts of pure water were mixed evenly, refluxed and extracted at 100-110° C. and 100-200 r / min for 2 h, filtered, and the filter residue was added to 9-11 parts of pure water, extracted again under the same conditions for 2 h, filtered, the two filtrates were combined, centrifuged at 4000-5000 rpm for 10-12 min, the supernatant was concentrated to 1 / 10 of the original volume at 55-65° C. under reduced pressure, 8-9 parts of 95% ethanol were added in 10 times, each time with an interval of 3-4 min, and allowed to stand at 4-5° C. for 22-26 h, centrifuged at 4000-5000 rpm for 10-12 min, the precipitate was dissolved in 1-2 parts of pure water, vacuum freeze-dried for 16-20 h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain polygonatum polysaccharide powder;

[0016] (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45-50° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, and loading into an extraction kettle, and supercritical extraction at 19-23 MPa, 40-45° C., and a carbon dioxide flow rate of 15-20 L / h for 4-5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0017] (5) Mix the formula amount of hawthorn, Sophora japonica, fried Shenqu with bran, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5000-6000 rpm for 12-15 minutes, concentrate under reduced pressure at 55-65° C. to 1 / 10 of the original volume, vacuum dry at 50-60° C. for 14-16 hours, crush with a high-speed grinder, and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0018] (6) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly according to their weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0019] As an optimization, the bracken hemp in step (2) is pre-treated by washing, slicing, drying to constant weight, and crushing with a high-speed grinder and then passing through a 40-mesh sieve.

[0020] As an optimization, the polygonatum sibiricum in step (3) is pretreated by drying, crushing it with a high-speed crusher and then passing it through a 40-mesh sieve.

[0021] As an optimization, the amount of refined honey used in step (6) is 125-155 g of refined honey per 100 g of medicinal materials.

[0022] As an optimization, the pills in step (6) are small honey pills or large honey pills.

[0023] Compared with the prior art, the beneficial effects achieved by the present invention are:

[0024] When preparing the traditional Chinese medicine weight loss and digestion pills, the present invention firstly uses a hot water / ethanol extraction method to extract effective active ingredients of bracken anserine and polygonatum to obtain bracken anserine powder and polygonatum polysaccharide powder; then uses a carbon dioxide supercritical extraction method to extract volatile oil and water-insoluble components in Pu'er tea, lotus leaves, coix seeds and tangerine peel to obtain a mixed medicinal material extract and a mixed medicinal material residue; hawthorn, sophora japonica flower, bran-fried Shenqu, scorched malt and the mixed medicinal material residue are decocted twice with water, the filtrate is combined, centrifuged, concentrated, dried and crushed to obtain medicinal material fine powder; bracken anserine powder, polygonatum polysaccharide powder, chicken gizzard lining-Poria powder, medicinal material fine powder and the mixed medicinal material extract are mixed and added with refined honey to prepare the traditional Chinese medicine weight loss and digestion pills.

[0025] Firstly, the hot water / ethanol extraction method is used to extract the weight loss and lipid-lowering ingredients in Fern Anse and Polygonatum sibiricum, thereby reducing the interference of other components on the effect of the finished product; the carbon dioxide supercritical extraction method is used to extract the volatile oils and water-insoluble components in Pu'er tea, lotus leaves, coix seeds, and tangerine peel in advance, thereby reducing the loss of their effective ingredients in the subsequent decoction process. At the same time, the carbon dioxide supercritical extraction method is better than the traditional hot water distillation volatile oil extraction method, with a larger extraction volume, thereby improving the digestion and weight loss effects of the finished Chinese medicine weight loss and digestion pills.

[0026] Secondly, the Pu'er tea in the prescription is warm in nature, bitter and astringent in taste, can reduce fat and lose weight, aid digestion, and warm the stomach; hawthorn is slightly warm in nature, sour and sweet in taste, can help digestion and invigorate the stomach, promote qi and disperse blood stasis, resolve turbidity and reduce fat; bran hemp is neutral in nature, bitter in taste, can clear away heat and dampness; polygonatum is neutral in nature, sweet in taste, can replenish qi and nourish yin, invigorate the spleen, moisten the lungs, and benefit the kidneys; poria is neutral in nature, sweet and light in taste, can promote diuresis and eliminate dampness, invigorate the spleen and calm the mind; coix seed is cool in nature, sweet and light in taste, can promote diuresis and eliminate dampness, invigorate the spleen and stop diarrhea, clear away heat and discharge pus; sophora japonica is slightly cold in nature, bitter in taste, can clear the liver and purge fire, cool blood and stop bleeding; tangerine peel is warm in nature, pungent and sweet in taste, can regulate qi and regulate the middle, dry dampness and resolve phlegm; fried bran shenqu is warm in nature, pungent and sweet in taste, can invigorate the spleen and harmonize the stomach, promote food and resolve accumulation; chicken gizzard lining is neutral in nature, sweet in taste, can invigorate the stomach and promote food; scorched malt is neutral in nature, bitter in taste, can promote qi and digestion, invigorate the spleen and stimulate appetite; Lotus leaf is cold in nature and bitter in taste, and can clear away heat and remove dampness, promote the clear yang, cool blood and stop bleeding; Achyranthes bidentata is neutral in nature and bitter and sour in taste, and can nourish the liver and kidney, strengthen the tendons and bones, guide blood downward, and promote blood circulation and dredge the menstruation; Pu'er tea is the main medicine in the prescription, which has the functions of lowering blood lipids and losing weight, and aiding digestion; hawthorn, Poria cocos, and Coix seed are the assistant medicines to assist in enhancing the effect of digestion; Poria cocos and Coix seed have the functions of strengthening the spleen and removing dampness, and help to improve the function of the digestive system; tangerine peel for regulating qi and regulating the middle, fried Shenqu with bran, chicken gizzard lining, and scorched malt for strengthening the spleen and eliminating food, lotus leaf for clearing away heat and removing dampness, and the ingredients extracted from Fern Hessus and Polygonatum sibiricum that are beneficial for weight loss and lowering blood lipids, and Achyranthes bidentata and Sophora japonica are the messengers, which guide the medicine downward, clear away heat and detoxify, to obtain a traditional Chinese medicine weight loss and digestion pill with the functions of digesting food, eliminating accumulation, losing weight and reducing blood lipids, and strengthening the spleen and removing dampness. DETAILED DESCRIPTION

[0027] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0028] Example 1

[0029] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0030] The formula is: by weight, 10 parts of Pu'er tea, 6 parts of hawthorn, 2 parts of bracken, 2 parts of polygonatum, 6 parts of tuckahoe, 3 parts of coix seeds, 2 parts of sophora japonica, 4 parts of tangerine peel, 8 parts of bran-fried Shenqu, 1 part of chicken gizzard lining, 3 parts of roasted malt, 4 parts of lotus leaves, and 1 part of Achyranthes bidentata;

[0031] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 45° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0032] (2) By weight, 1 part of Potentilla anserina and 4 parts of pure water were mixed evenly, incubated in a water bath at 55°C, 100 r / min for 50 h, filtered, and the filtrate was centrifuged at 4000 rpm for 12 min. The supernatant and 95% ethanol were mixed evenly in a volume ratio of 1:4, allowed to stand at room temperature for 10 h, centrifuged at 5000 rpm for 15 min, the supernatant was concentrated at 55°C under reduced pressure to 1 / 10 of the original volume, vacuum dried at 50°C for 16 h, crushed with a high-speed grinder, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0033] (3) According to the mass fraction, 1 part of Polygonatum sibiricum and 9 parts of pure water were mixed evenly, refluxed and extracted at 100°C and 100 r / min for 2 h, filtered, and the residue was added to 9 parts of pure water, extracted again under the same conditions for 2 h, filtered, the two filtrates were combined, centrifuged at 4000 rpm for 12 min, the supernatant was concentrated to 1 / 10 of the original volume at 55°C under reduced pressure, 8 parts of 95% ethanol were added in 10 times, each time with an interval of 3 min, and allowed to stand at 4°C for 26 h, centrifuged at 4000 rpm for 12 min, the precipitate was dissolved in 1 part of pure water, vacuum freeze-dried for 16 h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain Polygonatum sibiricum polysaccharide powder;

[0034] (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, loading into an extraction kettle, and supercritical extraction at 19 MPa, 45° C., and a carbon dioxide flow rate of 15 L / h for 5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0035] (5) Mix the formula amount of hawthorn, Sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5000 rpm for 15 minutes, concentrate at 55° C. to 1 / 10 of the original volume, vacuum dry at 50° C. for 16 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0036] (6) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly according to their weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0037] Example 2

[0038] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0039] The formula is: by weight, 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of bracken, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 2.5 parts of sophora japonica, 5 parts of tangerine peel, 9 parts of bran-fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0040] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0041] (2) By weight, 1 part of Potentilla anserina and 4.5 parts of pure water were mixed evenly, and the mixture was in a water bath at 60°C and 150 r / min for 48 h, filtered, and the filtrate was centrifuged at 4500 rpm for 11 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 12 h, and centrifuged at 5500 rpm for 13 min. The supernatant was concentrated at 60°C under reduced pressure to 1 / 10 of the original volume, and vacuum dried at 55°C for 15 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0042] (3) By weight, 1 part of Polygonatum sibiricum and 10 parts of pure water were mixed evenly, refluxed and extracted at 105°C, 150r / min for 2h, filtered, and the residue was added to 10 parts of pure water, extracted again under the same conditions for 2h, filtered, the two filtrates were combined, centrifuged at 4500rpm for 11min, the supernatant was concentrated to 1 / 10 of the original volume at 60°C under reduced pressure, 8.5 parts of 95% ethanol were added in 10 times, each time with an interval of 3min, and allowed to stand at 4°C for 24h, centrifuged at 4500rpm for 11min, the precipitate was dissolved in 1 part of pure water, vacuum freeze-dried for 18h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain Polygonatum sibiricum polysaccharide powder;

[0043] (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, loading into an extraction kettle, and supercritical extraction at 21 MPa, 42° C., and a carbon dioxide flow rate of 18 L / h for 4.5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0044] (5) Mix the formula amount of hawthorn, Sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5500 rpm for 13 minutes, concentrate at 60°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 55°C for 15 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0045] (6) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly according to their weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0046] Example 3

[0047] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0048] The formula is: by weight, 12 parts of Pu'er tea, 8 parts of hawthorn, 3 parts of bracken, 3 parts of polygonatum, 7 parts of tuckahoe, 4 parts of coix seeds, 3 parts of sophora japonica, 7 parts of tangerine peel, 10 parts of bran-fried Shenqu, 2 parts of chicken gizzard lining, 4 parts of roasted malt, 6 parts of lotus leaf, 1.5 parts of Achyranthes bidentata;

[0049] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0050] (2) By weight, 1 part of Potentilla anserina and 5 parts of pure water were mixed evenly, incubated in a water bath at 65°C and 200 r / min for 46 h, filtered, and the filtrate was centrifuged at 5000 rpm for 10 min. The supernatant and 95% ethanol were mixed evenly in a volume ratio of 1:4, allowed to stand at room temperature for 14 h, centrifuged at 6000 rpm for 12 min, and the supernatant was concentrated at 65°C under reduced pressure to 1 / 10 of the original volume, vacuum dried at 60°C for 16 h, crushed with a high-speed grinder, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0051] (3) According to the mass fraction, 1 part of Polygonatum sibiricum and 11 parts of pure water were mixed evenly, refluxed and extracted at 110°C and 200 r / min for 2 h, filtered, and the residue was added to 11 parts of pure water, extracted again under the same conditions for 2 h, filtered, the two filtrates were combined, centrifuged at 5000 rpm for 10 min, the supernatant was concentrated to 1 / 10 of the original volume at 65°C under reduced pressure, 9 parts of 95% ethanol were added in 10 times, each time with an interval of 4 min, and allowed to stand at 5°C for 22 h, centrifuged at 5000 rpm for 10 min, the precipitate was dissolved in 2 parts of pure water, vacuum freeze-dried for 20 h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain Polygonatum sibiricum polysaccharide powder;

[0052] (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 50° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, loading into an extraction kettle, and supercritical extraction at 23 MPa, 40° C., and a carbon dioxide flow rate of 20 L / h for 4 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0053] (5) Mix the formula amount of hawthorn, Sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 6000 rpm for 12 minutes, concentrate at 65°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 60°C for 14 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0054] (6) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly according to their weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0055] Comparative Example 1

[0056] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0057] The formula is: by weight, 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of bracken, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 2.5 parts of sophora japonica, 5 parts of tangerine peel, 9 parts of bran-fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0058] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0059] (2) According to the mass fraction, 1 part of polygonatum and 10 parts of pure water were mixed evenly, refluxed and extracted at 105°C and 150r / min for 2h, filtered, and the residue was added to 10 parts of pure water, extracted again under the same conditions for 2h, filtered, the two filtrates were combined, centrifuged at 4500rpm for 11min, the supernatant was concentrated to 1 / 10 of the original volume at 60°C under reduced pressure, 8.5 parts of 95% ethanol were added in 10 times, each time with an interval of 3min, and allowed to stand at 4°C for 24h, centrifuged at 4500rpm for 11min, the precipitate was dissolved in 1 part of pure water, vacuum freeze-dried for 18h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain polygonatum polysaccharide powder;

[0060] (3) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, loading into an extraction kettle, and supercritical extraction at 21 MPa, 42° C., and a carbon dioxide flow rate of 18 L / h for 4.5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0061] (4) Mix the formula amount of hawthorn, bracken, Sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5500 rpm for 13 minutes, concentrate at 60°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 55°C for 15 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0062] (5) According to the weight ratio, the polygonatum sibiricum polysaccharide powder, chicken gizzard lining-Poria cocos powder, medicinal material powder, and mixed medicinal material extract are mixed evenly, and refined honey is added to make pills to prepare Chinese medicine weight loss and digestion pills.

[0063] Comparative Example 2

[0064] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0065] The formula is: by weight, 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of bracken, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 2.5 parts of sophora japonica, 5 parts of tangerine peel, 9 parts of bran-fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0066] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0067] (2) By weight, 1 part of Potentilla anserina and 4.5 parts of pure water were mixed evenly, and the mixture was in a water bath at 60°C and 150 r / min for 48 h, filtered, and the filtrate was centrifuged at 4500 rpm for 11 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 12 h, and centrifuged at 5500 rpm for 13 min. The supernatant was concentrated at 60°C under reduced pressure to 1 / 10 of the original volume, and vacuum dried at 55°C for 15 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0068] (3) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, loading into an extraction kettle, and supercritical extraction at 21 MPa, 42° C., and a carbon dioxide flow rate of 18 L / h for 4.5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue;

[0069] (4) Mix the formula amount of hawthorn, polygonatum, sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same amount of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5500 rpm for 13 minutes, concentrate at 60°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 55°C for 15 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0070] (5) Mix the formulated amounts of Potentilla anserina powder, Chicken Gizzard Stone-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly by weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0071] Comparative Example 3

[0072] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0073] The formula is: by weight, 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of bracken, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 2.5 parts of sophora japonica, 5 parts of tangerine peel, 9 parts of bran-fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0074] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0075] (2) By weight, 1 part of Potentilla anserina and 4.5 parts of pure water were mixed evenly, and the mixture was in a water bath at 60°C and 150 r / min for 48 h, filtered, and the filtrate was centrifuged at 4500 rpm for 11 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 12 h, and centrifuged at 5500 rpm for 13 min. The supernatant was concentrated at 60°C under reduced pressure to 1 / 10 of the original volume, and vacuum dried at 55°C for 15 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0076] (3) By weight, 1 part of Polygonatum sibiricum and 10 parts of pure water were mixed evenly, refluxed and extracted at 105°C, 150r / min for 2h, filtered, and the residue was added to 10 parts of pure water, extracted again under the same conditions for 2h, filtered, the two filtrates were combined, centrifuged at 4500rpm for 11min, the supernatant was concentrated to 1 / 10 of the original volume at 60°C under reduced pressure, 8.5 parts of 95% ethanol were added in 10 times, each time with an interval of 3min, and allowed to stand at 4°C for 24h, centrifuged at 4500rpm for 11min, the precipitate was dissolved in 1 part of pure water, vacuum freeze-dried for 18h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain Polygonatum sibiricum polysaccharide powder;

[0077] (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, adding pure water 10 times the weight of the medicinal materials, soaking for 1.5 hours, extracting in a volatile oil extractor for 5 hours, and obtaining a mixed medicinal material extract and a mixed medicinal material residue;

[0078] (5) Mix the formula amount of hawthorn, Sophora japonica, bran fried Shenqu, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5500 rpm for 13 minutes, concentrate at 60°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 55°C for 15 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine medicinal powder;

[0079] (6) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, medicinal material powder, and mixed medicinal material extract uniformly according to their weight, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0080] Comparative Example 4

[0081] A method for preparing a Chinese medicine weight loss and digestion pill, comprising the following steps:

[0082] The formula is: by weight, 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of bracken, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 2.5 parts of sophora japonica, 5 parts of tangerine peel, 9 parts of bran-fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0083] (1) Mix the chicken's gizzard lining and Poria cocos in the formula amount, dry at 50° C. to constant weight, grind with a high-speed grinder, and pass through an 80-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder;

[0084] (2) By weight, 1 part of Potentilla anserina and 4.5 parts of pure water were mixed evenly, and the mixture was in a water bath at 60°C and 150 r / min for 48 h, filtered, and the filtrate was centrifuged at 4500 rpm for 11 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 12 h, and centrifuged at 5500 rpm for 13 min. The supernatant was concentrated at 60°C under reduced pressure to 1 / 10 of the original volume, and vacuum dried at 55°C for 15 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder;

[0085] (3) By weight, 1 part of Polygonatum sibiricum and 10 parts of pure water were mixed evenly, refluxed and extracted at 105°C, 150r / min for 2h, filtered, and the residue was added to 10 parts of pure water, extracted again under the same conditions for 2h, filtered, the two filtrates were combined, centrifuged at 4500rpm for 11min, the supernatant was concentrated to 1 / 10 of the original volume at 60°C under reduced pressure, 8.5 parts of 95% ethanol were added in 10 times, each time with an interval of 3min, and allowed to stand at 4°C for 24h, centrifuged at 4500rpm for 11min, the precipitate was dissolved in 1 part of pure water, vacuum freeze-dried for 18h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain Polygonatum sibiricum polysaccharide powder;

[0086] (4) Mix the formula amount of hawthorn, Sophora japonica flower, bran fried Shenqu, Pu'er tea, lotus leaf, coix seed, tangerine peel, scorched malt, and Achyranthes bidentata, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5500 rpm for 13 minutes, concentrate at 60°C under reduced pressure to 1 / 10 of the original volume, vacuum dry at 55°C for 15 hours, crush with a high-speed grinder and pass through an 80-mesh sieve to obtain a fine powder of the medicinal material;

[0087] (5) Mix the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria powder, and medicinal material fine powder evenly according to their weight parts, add refined honey to make pills, and prepare Chinese medicine weight loss and digestion pills.

[0088] Set up the following split for comparison:

[0089] Recipe 1: 11 parts of Pu'er tea, 7 parts of hawthorn, 2.5 parts of fern, 2.5 parts of polygonatum, 6.5 parts of tuckahoe, 3.5 parts of coix seeds, 5 parts of tangerine peel, 9 parts of bran fried Shenqu, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf;

[0090] Recipe 2: 11 parts of Pu'er tea, 7 parts of hawthorn, 6.5 parts of Poria cocos, 3.5 parts of coix seeds, 2.5 parts of Sophora japonica flowers, 1.2 parts of Achyranthes bidentata;

[0091] Recipe 3: 11 parts of Pu'er tea, 2.5 parts of fern, 2.5 parts of polygonatum, 2.5 parts of Sophora japonica, 5 parts of dried orange peel, 9 parts of fried Shenqu with bran, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0092] Recipe 4: 2.5 parts of fern, 2.5 parts of polygonatum, 2.5 parts of sophora japonica, 5 parts of dried tangerine peel, 9 parts of fried glutinous rice, 1.5 parts of chicken gizzard lining, 3.5 parts of roasted malt, 5 parts of lotus leaf, 1.2 parts of Achyranthes bidentata;

[0093] Recipe 5: 7 parts of hawthorn, 6.5 parts of poria, 3.5 parts of coix seed, 2.5 parts of Sophora japonica, and 1.2 parts of Achyranthes bidentata.

[0094] The above-mentioned prescriptions all adopt the preparation process of Example 2 to process the corresponding medicinal materials into pills.

[0095] Test Case

[0096] Experimental animals and feed:

[0097] Experimental animals: SPF-grade SD rats, male, weighing 160-200 g, were purchased from Hangzhou Ziyuan Experimental Animal Technology Co., Ltd.

[0098] Basic feed formula: barley flour 20%, dehydrated vegetables 10%, soybean meal 20%, yeast 1%, bone meal 5%, corn meal 16%, bran 16%, fish meal 10%, salt 2%;

[0099] High-fat feed formula: basic feed 51.8%, egg yolk powder 20%, lard 7%, milk powder 5%, white sugar 5%, cod liver oil 20 drops / kg, peanuts 2%, soybeans 5%, salt 1%, sesame oil 0.5%.

[0100] Experimental methods: Rats were housed under SPF conditions, at 25±1℃ indoors, with free access to drinking water, using a standard 12-h light-dark cycle, with water changed three times and bedding changed twice a week. All rats were randomly divided into a basal feed group and a high-fat feed group after one week of adaptive feeding. After 6 weeks of feeding, the basal feed group was used as a blank group. Rats whose weight in the high-fat feed group exceeded the average weight of the blank group by 20% were selected and randomly divided into groups. One group was used as a control group, and the other groups were fed with the Chinese medicine weight loss and digestion pills prepared by each embodiment, comparative example, and separated prescription, once a day, with a dosage of 0.1 g / 100 g each time. The control group and the blank group were fed with refined honey of the same mass, and their body weight was recorded once a week, and the average body weight was recorded. The rats were fed with the medicine for 6 weeks, and fasted but not watered for 12 h after the last feeding. After the rats were anesthetized with ether, 3 ml of blood was collected from the fundus venous plexus, and the blood was centrifuged at 2500 rpm for 10 min to separate the serum. The contents of total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum were determined using a fully automatic biochemical analyzer. The rats were killed by dislocating the cervical vertebra, and fresh liver tissue, kidney and adipose tissue around the genitals were dissected for subsequent analysis.

[0101] Data recording: 1. Observe and record the average body weight of rats in each group, record in Table 1; 2. Record the average weight of liver tissue and adipose tissue of rats in each group, record in Table 2; 3. Record the content of total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in rats in each group, record in Table 3.

[0102] The results are shown in Tables 1, 2 and 3.

[0103] Table 1

[0104]

[0105] Table 2

[0106]

[0107]

[0108] Table 3

[0109]

[0110] From the comparison of the experimental data in Tables 1 to 3, it can be found that the Chinese medicine weight-loss and digestion-promoting pills prepared by the present invention have good weight-loss and lipid-lowering effects.

[0111] By comparison, the separate extraction of the effective ingredients of Potentilla ansemen and Polygonatum sibiricum improves their effects on weight loss and digestion, while the application of supercritical carbon dioxide extraction also improves the use of medicinal materials and effectively improves the effects of digestion and weight loss. The experimental data of the split prescription also show that each medicinal material has played its role and has a certain effect, but not as good as the complete formula. Their synergistic effect has achieved good results.

[0112] The specific implementation methods described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine weight loss and digestion pill and a preparation method thereof, characterized in that: The Chinese medicine weight loss and digestion pill is prepared by mixing bracken powder, polygonatum polysaccharide powder, chicken gizzard lining-poria powder, medicinal material powder, mixed medicinal material extract, and refined honey; The bracken anserine powder and polygonatum sibiricum polysaccharide powder are prepared by extracting bracken anserine and polygonatum sibiricum with hot water / ethanol; The mixed medicinal material extract is prepared by extracting Pu'er tea, lotus leaf, coix seed and tangerine peel by supercritical carbon dioxide extraction; The medicinal material fine powder is prepared by boiling hawthorn, sophora japonica flower, bran-fried Shenqu, scorched malt and mixed medicinal material residues in water twice, combining the filtrate, centrifuging, concentrating, drying and pulverizing.

2. A Chinese medicine weight loss and digestion pill according to claim 1, characterized in that: The mixed medicinal material residue is the residue left after the mixed medicinal material extract is extracted from the formulated amount of Pu'er tea, lotus leaf, coix seed and tangerine peel by using the carbon dioxide supercritical extraction method.

3. A Chinese medicine weight loss and digestion pill according to claim 1, characterized in that: The chicken gizzard lining-Poria powder is prepared by mixing chicken gizzard lining and Poria, followed by drying and pulverizing.

4. A Chinese medicine weight loss and digestion pill according to claim 1, characterized in that: The formula of the Chinese medicine weight loss and digestion pill is, by weight, 10 to 12 parts of Pu'er tea, 6 to 8 parts of hawthorn, 2 to 3 parts of bracken, 2 to 3 parts of polygonatum, 6 to 7 parts of tuckahoe, 3 to 4 parts of coix seeds, 2 to 3 parts of sophora japonica flowers, 4 to 7 parts of tangerine peel, 8 to 10 parts of fried Shenqu with bran, 1 to 2 parts of chicken gizzard lining, 3 to 4 parts of roasted malt, 4 to 6 parts of lotus leaves, and 1 to 1.5 parts of Achyranthes bidentata.

5. A method for preparing a Chinese medicine weight loss and digestion pill, characterized in that: The method comprises the following preparation steps: (1) Mix the chicken's gizzard lining and Poria cocos in a formula amount, dry at 45-50° C. to constant weight, grind with a high-speed grinder, and pass through a 100-mesh sieve to obtain a chicken's gizzard lining-Poria cocos powder; (2) According to the mass ratio, 1 part of Potentilla anserina and 4-5 parts of pure water were mixed evenly, and the mixture was placed in a water bath at 55-65° C. and 100-200 r / min for 46-50 h, filtered, and the filtrate was centrifuged at 4000-5000 rpm for 10-12 min. The supernatant and 95% ethanol were mixed evenly at a volume ratio of 1:4, and allowed to stand at room temperature for 10-14 h, and centrifuged at 5000-6000 rpm for 12-15 min. The supernatant was concentrated under reduced pressure at 55-65° C. to 1 / 10 of the original volume, and vacuum dried at 50-60° C. for 14-16 h, crushed with a high-speed crusher, and passed through an 80-mesh sieve to obtain Potentilla anserina powder; (3) According to the mass fraction, 1 part of polygonatum and 9-11 parts of pure water were mixed evenly, refluxed and extracted at 100-110° C. and 100-200 r / min for 2 h, filtered, and the filter residue was added to 9-11 parts of pure water, extracted again under the same conditions for 2 h, filtered, the two filtrates were combined, centrifuged at 4000-5000 rpm for 10-12 min, the supernatant was concentrated to 1 / 10 of the original volume at 55-65° C. under reduced pressure, 8-9 parts of 95% ethanol were added in 10 times, each time with an interval of 3-4 min, and allowed to stand at 4-5° C. for 22-26 h, centrifuged at 4000-5000 rpm for 10-12 min, the precipitate was dissolved in 1-2 parts of pure water, vacuum freeze-dried for 16-20 h, crushed with a high-speed crusher and passed through an 80-mesh sieve to obtain polygonatum polysaccharide powder; (4) Weighing a formula amount of Pu'er tea, lotus leaf, coix seed, and tangerine peel, drying at 45-50° C. to constant weight, crushing with a high-speed grinder, passing through a 40-mesh sieve, and loading into an extraction kettle, and supercritical extraction at 19-23 MPa, 40-45° C., and a carbon dioxide flow rate of 15-20 L / h for 4-5 h to obtain a mixed medicinal material extract and a mixed medicinal material residue; (5) Mix the formula amount of hawthorn, Sophora japonica, fried Shenqu with bran, scorched malt, Achyranthes bidentata, and mixed medicinal residues, add 10 times the total weight of pure water, decoct for 1.5 hours, filter, retain the filtrate, add the same weight of pure water to the filter residue, decoct for another 2 hours, filter, combine the two filtrates, centrifuge at 5000-6000 rpm for 12-15 minutes, concentrate under reduced pressure at 55-65° C. to 1 / 10 of the original volume, vacuum dry at 50-60° C. for 14-16 hours, crush with a high-speed grinder, and pass through an 80-mesh sieve to obtain a fine medicinal powder; (6) According to the mass proportion, the formulated amounts of Potentilla anserina powder, Polygonatum sibiricum polysaccharide powder, Gallus gallus tuber-Poria cocos powder, medicinal material powder, and mixed medicinal material extract are mixed evenly, and refined honey is added to prepare small honey pills or large honey pills to prepare Chinese medicine weight loss and digestion pills.

6. The method for preparing a Chinese medicine weight loss and digestion pill according to claim 5, characterized in that: The bracken hemp in step (2) is pre-treated by washing, slicing, drying to constant weight, and crushing with a high-speed grinder and then passing through a 40-mesh sieve.

7. The method for preparing a Chinese medicine weight loss and digestion pill according to claim 5, characterized in that: The polygonatum sibiricum in step (3) is pre-treated by drying, crushing it with a high-speed crusher and then passing it through a 40-mesh sieve.

8. The method for preparing a Chinese medicine weight loss and digestion pill according to claim 5, characterized in that: The amount of refined honey used in step (6) is 125-155 g of refined honey per 100 g of medicinal materials.

9. The method for preparing a Chinese medicine weight loss and digestion pill according to claim 5, characterized in that: The pills in step (6) are small honey pills or large honey pills.

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