Drug release balloon, drug release instrument and endoscope assembly

Abstract

The invention discloses a drug release balloon, a drug release instrument and an endoscope assembly, and relates to the technical field of endoscopes. The drug release balloon comprises a balloon body, a dissolution layer and a drug carrier. A medicine carrier is arranged on the surface of a capsule body through a dissolving layer, the medicine carrier is arranged to comprise a pricking end, the pricking end can be used for being pricked into an external medium, meanwhile, the capsule body is arranged to be of an expandable structure, when the capsule body is in an expanded state, the pricking end is exposed out of the capsule body, and when the capsule body is in a contracted state, the pricking end is wrapped in the capsule body. In this way, the pricking end of the drug carrier is wrapped by the balloon body to avoid falling off before reaching the designated position, the balloon body is expanded after reaching the designated position, so that the pricking end can be matched with an external medium, and the problems that in the prior art, drugs on the balloon are prone to falling off before being applied, the drugs are difficult to send to the designated position for treatment, and the treatment effect is poor are solved. And the treatment effect is not good.

Description

Technical Field

[0001] The present invention relates to the field of endoscopes, and in particular to a drug releasing balloon, a drug releasing device and an endoscope component. Background Art

[0002] The uterine tamponade balloon is a medical device mainly used to treat gynecological diseases such as uterine bleeding. It can be used to place the balloon inside the uterus and expand the balloon to achieve the effect of expansion, compression and hemostasis. It can also be used to deliver drugs to the uterus through the balloon to treat the endometrium or repair the membrane layer.

[0003] However, coating the drug on the surface of the balloon can easily result in a loose connection between the drug and the balloon, causing the drug to fall off before or during the process of being delivered into the uterus. When the balloon is in the uterus, the position of the drug changes, making it difficult to treat the designated location, resulting in poor treatment effect. Summary of the invention

[0004] The present invention discloses an endoscope assembly and an endoscope, so as to at least partially improve the above technical problems.

[0005] In order to solve the above problems, the present invention adopts the following technical solutions: On the one hand, an embodiment of the present application provides a drug-releasing balloon, comprising: a capsule, a dissolving layer, and a drug carrier. An inner cavity is formed inside the capsule, and the capsule has a liquid inlet channel that passes through the inner cavity and the outside. The dissolving layer is arranged on the surface of the capsule and is connected to the liquid inlet channel. The drug carrier has an insertion end and a connecting end, and the connecting end is connected to the dissolving layer. The capsule is configured so that when the capsule is in an expanded state, the insertion end is exposed outside the capsule, and when the capsule is in a contracted state, the insertion end is wrapped inside the capsule.

[0006] In one embodiment, the capsule includes: a load-bearing portion and a rolling portion connected to each other, the connecting end is connected to the load-bearing portion, the rolling portion has deformation capability, when the capsule is in an expanded state, the insertion end is exposed outside the rolling portion, and when the capsule is in a contracted state, the insertion end is wrapped inside the rolling portion.

[0007] In one embodiment, the dissolution layer is connected to the connection end and extends out of the connection end to connect with the capsule body. The dissolution layer, the connection end and the capsule body together form a dissolution cavity, and the liquid inlet channel is connected to the dissolution cavity.

[0008] In one embodiment, the liquid inlet channel is arranged close to the edge of the dissolution chamber.

[0009] In one embodiment, a plurality of the liquid inlet channels are provided, and the plurality of the liquid inlet channels are evenly distributed and connected to the dissolution chamber.

[0010] In one embodiment, the bearing portion is provided with a mounting groove, and the drug carrier is disposed in the mounting groove.

[0011] In one embodiment, the insertion end includes at least one cone-shaped structure.

[0012] On the other hand, an embodiment of the present application also provides a drug release device, including a tube body and a drug release balloon as described above, wherein the distal end of the tube body is communicated with the inner cavity, and the distal end of the tube body is sealed and connected to the inner cavity, and the tube body is used to inject liquid into the inner cavity.

[0013] In one embodiment, the distal end of the tube body has a necked area, the radial dimension of the necked area is smaller than the radial dimension of the proximal end of the tube body, and the inner cavity is sealingly connected to the necked area.

[0014] On the other hand, an embodiment of the present application further provides an endoscope assembly, including an endoscope and a drug releasing device as described above, wherein the endoscope has an instrument channel, and the drug releasing device is detachably disposed in the instrument channel.

[0015] The technical solution adopted by the present invention can achieve the following beneficial effects: The drug release balloon provided by the embodiment of the present application sets the drug carrier on the surface of the capsule through the dissolving layer, and sets the drug carrier to include an insertion end, which can be used to insert into the external medium, for example, the endometrium, and the capsule is set to an expandable structure. When the capsule is in an expanded state, the insertion end is exposed outside the capsule, and when the capsule is in a contracted state, the insertion end is wrapped in the capsule. In this way, the insertion end of the drug carrier can be wrapped by the capsule to prevent it from falling off before reaching the specified position. After reaching the specified position, the capsule is expanded so that the insertion end can cooperate with the external medium, and the dissolving layer can be dissolved by the dissolving liquid that is injected into the capsule and expands the capsule, so that the drug carrier can fall off from the capsule, solving the problem that the drug on the balloon in the prior art is easy to fall off before applying the drug, making it difficult to deliver the drug to the specified position for treatment, resulting in poor treatment effect. The above-mentioned drug release balloon can also be applied to the drug release device to solve the above-mentioned problem. The above-mentioned drug release device can also be applied to the endoscope assembly to solve the above-mentioned problem. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 A schematic diagram showing a structure in which a capsule in an endoscope assembly in an embodiment of the present application is in a contracted state; Figure 2 A schematic diagram showing the structure of a balloon in an endoscope assembly in an embodiment of the present application in an expanded state; Figure 3 A schematic diagram of the structure of an endoscope assembly in one embodiment of the present application, in which the cyst is in a contracted state after being inserted into the uterus; Figure 4 A schematic diagram of the structure of an endoscope assembly in an embodiment of the present application, in which the capsule is in an expanded state after being inserted into the uterus; Figure 5 for Figure 1 The enlarged view of point A in the middle; Figure 6 A cross-sectional view showing a partial structure of an endoscope assembly in one embodiment of the present application; Figure 7 A partial structural schematic diagram showing a drug-releasing balloon in an embodiment of the present application in a contracted state; Figure 8 A schematic diagram showing the structure of a drug-releasing balloon in an embodiment of the present application in which the balloon is in an expanded state and in contact with the endometrium; Fig. 9 for Figure 8 Enlarged view of point B in the middle.

[0018] In the figure: 1. endoscope assembly; 10. drug release device; 110. drug release balloon; 111. balloon body; 1111. inner cavity; 1112. liquid inlet channel; 1113. bearing part; 1114. winding part; 1115. mounting groove; 112. dissolving layer; 1121. dissolving cavity; 113. drug carrier; 1131. insertion end; 1132. connecting end; 120. tube body; 121. shrinkage area; 20. endoscope; 210. instrument channel; 220. injection channel; 2. uterus. DETAILED DESCRIPTION

[0019] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0020] The terms "first", "second", etc. in the specification and claims of the present application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable under appropriate circumstances, so that the embodiments of the present application can be implemented in an order other than those illustrated or described here, and the objects distinguished by "first", "second", etc. are generally of one type, and the number of objects is not limited. For example, the first object can be one or more. In addition, "and / or" in the specification and claims represents at least one of the connected objects, and the character " / " generally indicates that the objects associated with each other are in an "or" relationship.

[0021] In each embodiment of the present application, "proximal end" and "distal end" refer to the position of each component relative to the user in the use environment, wherein the end closer to the user is designated as the "proximal end" and the end farther from the user is designated as the "distal end".

[0022] The inventive concept of the present application is described here: The uterine tamponade balloon is a medical device mainly used to treat gynecological diseases such as uterine bleeding. It can be used to place the balloon inside the uterus and expand the balloon to achieve the effect of expansion, compression and hemostasis. It can also be used to deliver drugs to the uterus through the balloon to treat the endometrium or repair the membrane layer.

[0023] However, coating the drug on the surface of the balloon is prone to loose connection between the drug and the balloon, resulting in drug shedding before or during the balloon is placed in the uterus. When the balloon is in the uterus, the position of the drug changes, making it difficult to treat the designated location, resulting in poor treatment effect. Although the method of fixed-point injection of drugs can ensure that the drug can fully contact the endometrium, this method not only has a small range of action, but also is very complicated to operate.

[0024] Based on this, the inventor provides a drug-releasing balloon, a drug-releasing device, and an endoscope assembly. The drug-releasing balloon can be configured as a structure in which a drug carrier and a capsule are connected by a dissolving layer. The capsule is configured so that when the capsule is in an expanded state, the insertion end of the drug carrier is exposed outside the capsule, so that the drug carrier can contact and treat the target medium. After the drug carrier is inserted into the target medium, the dissolving layer can be injected into the capsule and the dissolving liquid that expands the capsule can be dissolved, thereby causing the drug carrier to detach from the capsule to apply the drug to the target medium. When the capsule is in a contracted state, the insertion end of the drug carrier is wrapped in the capsule to prevent the drug carrier from being affected by the external environment before applying the drug to the target medium, causing the drug carrier to fall off, thereby affecting the subsequent application of the drug to the target medium.

[0025] The following is combined with Figures 1 to 9 , a drug releasing balloon 110, a drug releasing device 10 and an endoscope assembly 1 provided in the present application are described in detail through specific embodiments and their application scenarios.

[0026] Please also see Figure 1-Figure 4 The embodiment of the present application provides an endoscope assembly 1, which can be used to apply medicine to the endometrium to treat or repair the endometrium. The endoscope assembly 1 may include: an endoscope 20 and a drug release device 10, the endoscope 20 can be used as a carrier of the drug release device 10, the drug release device 10 is delivered into the uterus 2 through the endoscope 20, and the drug is attached to the endometrium by the drug release device 10.

[0027] Please also see Figure 1 and Figure 5 The endoscope 20 may have an instrument channel 210 and an injection channel 220. The instrument channel 210 may be used to accommodate the drug release device 10, and the injection channel 220 may be connected to the drug release device 10. In this embodiment, the drug release device 10 is detachably disposed in the instrument channel 210, so that the endoscope 20 can be reused.

[0028] Please also see Figure 1 , Figure 5 and Figure 6The drug release device 10 may include: a tube body 120 and a drug release balloon 110. The distal end of the tube body 120 may be connected to the drug release balloon 110, and the distal end of the tube body 120 may be sealed and connected to the inner cavity 1111. The tube body 120 may be connected to the injection channel 220. The operator may inject liquid into the tube body 120 through the injection channel 220, so that the dissolved liquid enters the drug release balloon 110. The embodiment of the present application does not limit the dissolved liquid injected into the drug release balloon 110, for example, it may be physiological saline. The drug release balloon 110 will swell after being injected with the dissolved liquid, so that the drug can contact the target medium, such as the endometrium, and then perform targeted treatment on the target medium.

[0029] Please continue reading Figure 6 In one embodiment, the distal end of the tube body 120 may have a constricted area 121, the radial dimension of the constricted area 121 may be smaller than the radial dimension of the proximal end of the tube body 120, and the drug release balloon 110 may be sealed and connected to the constricted area 121. In this way, the dimensions of the entire drug release device 10 are consistent, and the distal end of the drug release device 10 is prevented from becoming larger in size after being connected to the drug release balloon 110, which makes it difficult to move smoothly in the device channel 210.

[0030] Furthermore, in some embodiments, the tube body 120 can be extended into the interior of the drug releasing balloon 110. It can be understood that since the drug releasing balloon 110 has a low structural strength and is prone to collapse when in a contracted state, extending the tube body 120 into the interior of the drug releasing balloon 110 can make the tube body 120 serve as a supporting structure of the drug releasing balloon 110, thereby facilitating the delivery of the drug releasing device 10 into the uterus 2. At the same time, the tube body 120 can also play a guiding role during the delivery into the uterus 2.

[0031] See also Figure 7 The drug release balloon 110 may include: a capsule 111, a dissolving layer 112 and a drug carrier 113. The capsule 111 forms an inner cavity 1111, and the capsule 111 also has a liquid inlet channel 1112 that passes through the inner cavity 1111 and the outside. As mentioned above, the tube 120 can extend into the inner cavity 1111 and inject liquid into the inner cavity 1111.

[0032] Specifically, in this embodiment, the capsule 111 can be configured such that when the capsule 111 is in an expanded state, the drug carrier 113 can be exposed outside the capsule 111, and when the capsule 111 is in a contracted state, the drug carrier 113 can be wrapped inside the capsule 111. This can not only prevent the drug carrier 113 from falling off before applying the drug, but also ensure that the drug carrier 113 can be well matched with the target medium during the application of the drug.

[0033] The dissolving layer 112 can be disposed on the surface of the capsule 111 and communicated with the liquid inlet channel 1112. In a preferred embodiment, the dissolving layer 112 can be located at the channel opening of the liquid inlet channel 1112, so that the dissolving liquid in the liquid inlet channel 1112 can contact the dissolving layer 112 for the first time and promote the dissolution of the dissolving layer 112. The embodiment of the present application does not limit the specific form of the dissolving layer 112. For example, in an embodiment, the dissolving layer 112 can be gelatin, starch, sodium alginate or chitosan, etc., which can be set according to actual conditions.

[0034] The drug carrier 113 may have an insertion end 1131 and a connection end 1132, the connection end 1132 may be connected to the dissolving layer 112, the insertion end 1131 may be arranged outward away from the capsule 111, and the insertion end 1131 may be used to be inserted into and fixed to the target medium. As mentioned above, when the capsule 111 is in an expanded state, the insertion end 1131 may be exposed outside the capsule 111, and the insertion end 1131 may be inserted into and fixed to the target medium. At the same time, the dissolving liquid injected into the capsule 111 may contact the dissolving layer 112 through the liquid inlet channel 1112, so that the dissolving layer 112 is dissolved, and the drug carrier 113 will be separated from the capsule 111, thereby fixing the drug carrier 113 to the target medium and accurately treating the target medium.

[0035] In one embodiment, the insertion end 1131 may include at least one conical structure, so that the insertion end 1131 can be inserted into the target medium more conveniently and stably. The embodiment of the present application does not limit the specific form and number of the conical structure. For example, the outer surface of the conical structure can be set to a curved structure similar to a snake, and the number of conical structures can be set to two or three, etc., which can be set according to actual conditions and are not limited here.

[0036] The drug carrier 113 can carry drugs, and when the insertion end 1131 is fixed to the target medium, the drug can accurately treat the target medium. It should be noted that in some embodiments, the drug carrier 113 can be composed of drugs, and in other embodiments, it can also be composed of drugs and porous carriers. In this embodiment, the porous carrier can be an inorganic carrier, such as silicon dioxide, aluminum hydroxide, etc. For example, in another embodiment, the porous carrier can also be an organic carrier, such as polyester, polyamide, polyorthoester, polyethylene oxide, polyamide ester, etc., which can be set according to actual conditions and are not limited here.

[0037] Please also see Figure 7-Figure 9In one embodiment, the capsule 111 may include a load-bearing portion 1113 and a reeling portion 1114 connected to each other, the connecting end 1132 may be connected to the load-bearing portion 1113, and the reeling portion 1114 may have a deformable ability. When the capsule 111 is in an expanded state, the insertion end 1131 may be exposed outside the reeling portion 1114, and when the capsule 111 is in a contracted state, the insertion end 1131 may be wrapped inside the reeling portion 1114. The embodiment of the present application does not limit the reeling and unfolding methods of the reeling portion 1114. For example, in one embodiment, the reeling portion 1114 may approach the load-bearing portion 1113 during the reeling process and wrap the load-bearing portion 1113.

[0038] See also Fig. 9 Furthermore, in one embodiment, the supporting portion 1113 may be provided with a mounting groove 1115, and the drug carrier 113 may be disposed in the mounting groove 1115. The setting of the mounting groove 1115 may further improve the stability of the connection between the drug carrier 113 and the capsule 111, thereby preventing the drug carrier 113 from being separated from the capsule 111 before applying the drug.

[0039] In a more specific embodiment, the bearing portion 1113 can also be configured to have a deformable ability, that is, when the capsule 111 is in an expanded state, the bearing portion 1113 will also expand accordingly, and the size of the mounting groove 1115 will increase, and the drug carrier 113 located in the mounting groove 1115 can be naturally separated from the mounting groove 1115. When the capsule 111 is in a contracted state, the bearing portion 1113 will also contract accordingly, and the size of the mounting groove 1115 will decrease, and the drug carrier 113 located in the mounting groove 1115 can be clamped by the mounting groove 1115, thereby improving the stability of the connection between the drug carrier 113 and the capsule 111, and preventing the drug carrier 113 from being separated from the capsule 111 before the drug is applied. That is to say, in this embodiment, the drug release balloon 110 can not only avoid the risk of the drug carrier 113 being separated before the drug is applied, but also facilitate the application of the drug.

[0040] In addition, in one embodiment, the dissolving layer 112 can be connected to the connecting end 1132, and the connecting end 1132 can be extended to connect with the capsule 111. The dissolving layer 112, the connecting end 1132 and the capsule 111 together form a dissolving cavity 1121, and the liquid inlet channel 1112 is connected to the dissolving cavity 1121. That is to say, in this embodiment, the dissolving layer 112 can be a hollow structure, which not only reduces costs, but also allows the dissolving layer 112 to be dissolved faster, thereby avoiding the drug release balloon 110 being in an expanded state for a long time and causing discomfort to the patient.

[0041] Furthermore, in one embodiment, the liquid inlet channel 1112 can be arranged close to the edge of the dissolution chamber 1121, so that the dissolution layer 112 can contact with the dissolution liquid faster, and thus the dissolution layer 112 can be dissolved faster.

[0042] It can be understood that in some other embodiments, a plurality of liquid inlet channels 1112 can be provided, and the plurality of liquid inlet channels 1112 can be evenly distributed and connected to the dissolution chamber 1121, which can also enable the dissolution layer 112 to contact with the dissolving liquid faster, thereby enabling the dissolution layer 112 to be dissolved faster.

[0043] In summary, the drug releasing balloon 110 provided in the embodiment of the present application is configured such that the drug carrier 113 is disposed on the surface of the capsule body 111 through the dissolving layer 112, and the drug carrier 113 is configured to include an insertion end 1131, and the insertion end 1131 can be used to be inserted into an external medium, for example, can be inserted into the endometrium, and the capsule body 111 is configured to be an expandable structure. When the capsule body 111 is in an expanded state, the insertion end 1131 is exposed to the outside of the capsule body 111, and when the capsule body 111 is in a contracted state, the insertion end 1131 is wrapped in the capsule body 111. In this way, the insertion end 1131 of the drug carrier 113 can be wrapped by the capsule 111 before reaching the designated position to prevent it from falling off. After reaching the designated position, the capsule 111 is expanded so that the insertion end 1131 can cooperate with the external medium, and the dissolving layer 112 can be dissolved by the dissolving liquid injected into the capsule 111 and causing the capsule 111 to expand, so that the drug carrier 113 can fall off from the capsule 111, solving the problem in the prior art that the drug on the balloon is easy to fall off before applying the drug, making it difficult to deliver the drug to the designated position for treatment, resulting in poor treatment effect. The above-mentioned drug release balloon 110 can also be applied to the drug release device 10 to solve the above-mentioned problem. The above-mentioned drug release device 10 can also be applied to the endoscope assembly 1 to solve the above-mentioned problem.

[0044] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0045] In addition, it should be noted that the scope of the methods and devices in the embodiments of the present application is not limited to performing functions in the order shown or discussed, and may also include performing functions in a substantially simultaneous manner or in a reverse order according to the functions involved. For example, the described methods may be performed in an order different from that described, and various steps may be added, omitted, or combined. In addition, features described with reference to certain examples may be combined in other examples.

[0046] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A drug releasing balloon, characterized in that: include: A capsule body, wherein an inner cavity is formed inside the capsule body, and the capsule body has a liquid inlet channel penetrating the inner cavity and the outside; a dissolving layer, the dissolving layer being disposed on the surface of the capsule and communicating with the liquid inlet channel; and A drug carrier, the drug carrier having an insertion end and a connection end, the connection end being connected to the dissolution layer; Wherein, the sac is configured such that when the sac is in an expanded state, the insertion end is exposed outside the sac, and when the sac is in a contracted state, the insertion end is wrapped inside the sac.

2. The drug-releasing balloon according to claim 1, characterized in that: The sac body includes: a load-bearing portion and a rolling portion which are connected to each other, the connecting end is connected to the load-bearing portion, the rolling portion has deformation capability, when the sac body is in an expanded state, the insertion end is exposed outside the rolling portion, when the sac body is in a contracted state, the insertion end is wrapped inside the rolling portion.

3. The drug-releasing balloon according to claim 2, characterized in that: The dissolution layer is connected to the connection end and extends out of the connection end to be connected to the capsule body. The dissolution layer, the connection end and the capsule body together form a dissolution cavity, and the liquid inlet channel is communicated with the dissolution cavity.

4. The drug-releasing balloon according to claim 3, characterized in that: The liquid inlet channel is arranged close to the edge of the dissolution chamber.

5. The drug-releasing balloon according to claim 3, characterized in that: The liquid inlet channels are provided with a plurality of them, and the plurality of liquid inlet channels are evenly distributed and connected with the dissolution chamber.

6. The drug-releasing balloon according to any one of claims 2 to 5, characterized in that: The bearing portion is provided with a mounting groove, and the drug carrier is arranged in the mounting groove.

7. The drug-releasing balloon according to claim 1, characterized in that: The insertion end includes at least one cone-shaped structure.

8. A drug release device, characterized in that: include: A tube body and a drug-releasing balloon as claimed in any one of claims 1 to 7, wherein the distal end of the tube body is communicated with the inner cavity, and the distal end of the tube body is sealedly connected to the inner cavity, and the tube body is used to inject liquid into the inner cavity.

9. The drug release device according to claim 8, characterized in that: The distal end of the tube body has a constricted area, the radial dimension of the constricted area is smaller than the radial dimension of the proximal end of the tube body, and the inner cavity is sealingly connected to the constricted area.

10. An endoscope assembly, characterized in that: It comprises an endoscope and a drug releasing device as described in any one of claims 8 to 9, wherein the endoscope has an instrument channel, and the drug releasing device is detachably disposed in the instrument channel.

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