Nutritional supplement for preventing Alzheimer disease as well as tablet and preparation method thereof

Abstract

The invention provides a nutritional supplement for preventing Alzheimer disease as well as a tablet and a preparation method thereof, and belongs to the field of functional food processing. On the first aspect, the invention provides the nutritional supplement for preventing the Alzheimer disease, and the raw materials of the nutritional supplement comprise lactitol, blueberry powder, cis-15-tetracosenoic acid, tea theanine, phosphatidylserine, sea cucumber peptide and magnesium stearate; on the second aspect, the invention provides a preparation method of the cis-15-tetracosenoic acid microcapsule; in the third aspect, the invention also provides a preparation method of tablets of the nutritional supplement for preventing Alzheimer's disease. In the fourth aspect, the invention also provides an application of the nutritional supplement or the tablets of the nutritional supplement in preparation of foods such as health foods and the like. Compared with the prior art, the nutritional supplement for preventing Alzheimer's disease has the advantages that the indexes of intelligence development and the like are obviously improved.

Description

Technical Field

[0001] The present invention relates to the field of functional food processing, and in particular to a nutritional supplement for preventing Alzheimer's disease, a tablet thereof and a preparation method thereof. Background Art

[0002] Dietary supplements for preventing Alzheimer's disease have broad market prospects. With the improvement of people's living standards and the acceleration of the pace of life, people are looking for dietary supplements to develop in a convenient and healthy way while maintaining their traditional advantages, which brings new opportunities for the development of dietary supplements for preventing Alzheimer's disease.

[0003] The rapid development of modern society has brought about economic growth and convenience in life, but it has also created many new problems. For example, stress and sub-health conditions. The anxiety, depression, insomnia and other conditions caused by stress will cause certain damage to people's brains, and the most direct result is the occurrence of symptoms such as headaches and memory loss. In addition, the natural aging of the human body, brain trauma and brain degenerative diseases can also cause memory degradation. Cognition and memory, as basic functions, are related to all aspects of human life. Studies have shown that after entering old age, cognitive and memory functions will decline to a certain extent. Driven by the extension of life expectancy, the elderly population around the world has seen an unprecedented increase.

[0004] There are also a larger number of patients with mild cognitive impairment, which will eventually turn into Alzheimer's disease. Alzheimer's patients have serious functional impairments in life, which is bound to receive more and more attention and attention from the society. In addition, Parkinson's disease, vascular diseases, diet, fatigue, etc. can also cause the decline of cognitive and memory functions. In view of the above situation, memory-improving health foods are receiving more and more attention, and the market prospects are promising.

[0005] Aging is usually accompanied by a decline in memory function. Studies have shown that this phenomenon originates from changes in synapses. Although age-related cognitive decline does not significantly affect daily life, a certain degree of cognitive decline will still reduce the quality of life and reduce interpersonal communication. Some age-related memory decline will gradually develop into Alzheimer's disease with neurological degeneration. As the disease progresses, the person will gradually lose the ability to take care of himself. Pathologically, it manifests as a large amount of β-amyloid protein accumulation and neurofibrillary tangles in the brain. In addition, cerebrovascular diseases, exogenous brain damage, nerve-damaging drugs, and certain dietary ingredients can also cause a decline in memory function.

[0006] The etiology and pathogenesis of AD are relatively complex and have not yet been clarified. There are also many hypotheses. In the pre-oral clinical treatment, targeted treatment is adopted according to the hypothesis, including the use of acetylcholine inhibitors, metabolic drugs, anti-inflammatory drugs, antioxidants, β-endocrine enzyme inhibitors, etc. However, the above treatment methods have certain limitations and cannot cure Alzheimer's disease. Therefore, the prevention of Alzheimer's disease is particularly important.

[0007] Dietary supplements that prevent Alzheimer's disease are still scarce on the market.

[0008] Therefore, it is imperative to develop and optimize new raw materials and formulas for dietary supplements for the prevention of Alzheimer's disease, and to develop new dietary supplements for the prevention of Alzheimer's disease.

[0009] In view of this, the present invention provides a nutritional supplement for preventing Alzheimer's disease, a tablet thereof and a preparation method thereof. Summary of the invention

[0010] The purpose of the present invention is to provide a nutritional supplement for preventing Alzheimer's disease and a tablet thereof and a preparation method thereof.

[0011] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted:

[0012] In a first aspect, the present invention provides a nutritional supplement for preventing Alzheimer's disease. The raw materials of the nutritional supplement for preventing Alzheimer's disease include lactitol, blueberry powder, cis-15-tetracosenoic acid, tea theanine, phosphatidylserine, sea cucumber peptide, and magnesium stearate.

[0013] Furthermore, in a preferred embodiment of the present invention, the raw materials of the nutritional supplement for preventing Alzheimer's disease include 600-660 parts of lactitol, 180-220 parts of blueberry powder, 8-12 parts of cis-15-tetracosenoic acid, 80-100 parts of tea theanine, 28-32 parts of phosphatidylserine, 28-32 parts of sea cucumber peptide, and 8-12 parts of magnesium stearate, measured by weight.

[0014] Furthermore, in a preferred embodiment of the present invention, the raw materials of the nutritional supplement for preventing Alzheimer's disease include 630 parts of lactitol, 200 parts of blueberry powder, 10 parts of cis-15-tetracosenoic acid, 90 parts of tea theanine, 30 parts of phosphatidylserine, 30 parts of sea cucumber peptide, and 10 parts of magnesium stearate, by weight.

[0015] Furthermore, the feeding form of cis-15-tetracosenoic acid can be cis-15-tetracosenoic acid microcapsules.

[0016] In a second aspect, the present invention also provides a method for preparing cis-15-tetracosenoic acid microcapsules.

[0017] The cis-15-tetracosenoic acid microcapsules can be obtained by the following method: 550-650 parts by weight of β-cyclodextrin are dissolved in 5500-6500 parts by weight of distilled water to prepare a supersaturated solution, 95-105 parts of cis-15-tetracosenoic acid are added, and the mixture is subjected to high-speed emulsification and shearing for 3 minutes at 43-47° C. and a rotation speed of 10000-12000 r / min to obtain a final emulsion with an inlet temperature of 180° C. and an outlet temperature of 80° C., and the mixture is spray-dried to obtain the cis-15-tetracosenoic acid microcapsules.

[0018] Furthermore, the amount of β-cyclodextrin is 600 parts, the amount of distilled water is 6000 parts, the amount of cis-15-tetracosenoic acid is 100 parts, the emulsification temperature is 45° C., and the rotation speed is 10500 r / min.

[0019] In a third aspect, the present invention also provides a method for preparing tablets of a nutritional supplement for preventing Alzheimer's disease.

[0020] The tablet preparation method of the nutritional supplement for preventing Alzheimer's disease can be obtained by the following method: the raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-14 mesh sieve, dried, granulated, passed through a 16-18 mesh sieve, magnesium stearate is added to the granules, mixed evenly and then compressed into tablets.

[0021] In a fourth aspect, the present invention also provides a use of the nutritional supplement or the nutritional supplement tablet in the preparation of health food and other foods.

[0022] Compared with the prior art, the beneficial effects of the present invention include:

[0023] Nutritional supplements for preventing Alzheimer's disease have significantly improved indicators such as intelligence compared to existing technologies. DETAILED DESCRIPTION

[0024] The embodiments of the present invention will be described in detail below in conjunction with the examples, but it will be appreciated by those skilled in the art that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention. If specific conditions are not specified in the examples, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0025] The features and properties of the present invention are further described in detail below in conjunction with the embodiments:

[0026] Example 1

[0027] 600g of lactitol, 220g of blueberry powder, 8g of cis-15-tetracosenoic acid, 100g of tea theanine, 28g of phosphatidylserine, 32g of sea cucumber peptide, and 8g of magnesium stearate.

[0028] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0029] Example 2

[0030] 660g of lactitol, 180g of blueberry powder, 12g of cis-15-tetracosenoic acid, 80g of tea theanine, 32g of phosphatidylserine, 28g of sea cucumber peptide, and 12g of magnesium stearate.

[0031] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 14-mesh sieve, dried, granulated, passed through an 18-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0032] Example 3

[0033] 630g of lactitol, 200g of blueberry powder, 10g of cis-15-tetracosenoic acid, 90g of tea theanine, 30g of phosphatidylserine, 30g of sea cucumber peptide, and 10g of magnesium stearate.

[0034] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0035] Example 4

[0036] The cis-15-tetracosenoic acid microcapsules were obtained by the following method: 5500 grams of β-cyclodextrin was dissolved in 65000 ml of distilled water to prepare a supersaturated solution, 950 grams of cis-15-tetracosenoic acid was added, the mixture was subjected to high-speed emulsification and shearing at 47° C. and 10000 r / min to obtain a final emulsion, the inlet temperature was 180° C., the outlet temperature was 80° C., and the mixture was spray-dried to obtain the cis-15-tetracosenoic acid microcapsules.

[0037] 630 grams of lactitol, 200 grams of blueberry powder, 10 grams of cis-15-tetracosenoic acid (after conversion, it is added in the form of cis-15-tetracosenoic acid microcapsules), 90 grams of tea theanine, 30 grams of phosphatidylserine, 30 grams of sea cucumber peptide, and 10 grams of magnesium stearate.

[0038] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0039] Example 5

[0040] The cis-15-tetracosenoic acid microcapsules were obtained by the following method: 6500 grams of β-cyclodextrin was dissolved in 55000 ml of distilled water to prepare a supersaturated solution, 1050 grams of cis-15-tetracosenoic acid was added, the mixture was subjected to high-speed emulsification and shearing at 43° C. and 12000 r / min to obtain a final emulsion, the inlet temperature was 180° C., the outlet temperature was 80° C., and the mixture was spray-dried to obtain the cis-15-tetracosenoic acid microcapsules.

[0041] 630 grams of lactitol, 200 grams of blueberry powder, 10 grams of cis-15-tetracosenoic acid (after conversion, it is added in the form of cis-15-tetracosenoic acid microcapsules), 90 grams of tea theanine, 30 grams of phosphatidylserine, 30 grams of sea cucumber peptide, and 10 grams of magnesium stearate.

[0042] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0043] Example 6

[0044] The cis-15-tetracosenoic acid microcapsules are obtained by the following method: 6000 grams of β-cyclodextrin is dissolved in 60000 ml of distilled water to prepare a supersaturated solution, 1000 grams of cis-15-tetracosenoic acid is added, the mixture is subjected to high-speed emulsification and shearing at 45° C. and 11000 r / min to obtain a final emulsion, the inlet temperature is 180° C., the outlet temperature is 80° C., and the mixture is spray-dried to obtain the cis-15-tetracosenoic acid microcapsules.

[0045] 630 grams of lactitol, 200 grams of blueberry powder, 10 grams of cis-15-tetracosenoic acid (after conversion, it is added in the form of cis-15-tetracosenoic acid microcapsules), 90 grams of tea theanine, 30 grams of phosphatidylserine, 30 grams of sea cucumber peptide, and 10 grams of magnesium stearate.

[0046] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0047] Comparative Example 1

[0048] 790g lactitol, 200g blueberry powder, 10g magnesium stearate.

[0049] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0050] Comparative Example 2

[0051] 980 grams of lactitol, 10 grams of cis-15-tetracosenoic acid, and 10 grams of magnesium stearate.

[0052] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0053] Comparative Example 3

[0054] 900 grams of lactitol, 90 grams of tea theanine, and 10 grams of magnesium stearate.

[0055] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0056] Comparative Example 4

[0057] 960g of lactitol, 30g of phosphatidylserine, and 10g of magnesium stearate.

[0058] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0059] Comparative Example 5

[0060] 960g of lactitol, 30g of sea cucumber peptide, and 10g of magnesium stearate.

[0061] The raw materials except magnesium stearate are wet granulated, and then wet granulated, passed through a 12-mesh sieve, dried, granulated, passed through a 16-mesh sieve, magnesium stearate is added to the granules, mixed evenly, and then tableted to obtain the product.

[0062] Beneficial effects of the present invention:

[0063] 1. Intelligence-enhancing experiment

[0064] (1) Methods

[0065] After the experimental animals were adapted to the standard environment for 1 week, the model group was subcutaneously injected with D-galactose 150mg / (kg·d) for 6 consecutive weeks, and 4nmol / L Aβ25-35 was injected into the bilateral hippocampus in the 7th week to replicate the Alzheimer's disease model. After the model was successful, the rats were randomly divided into the model group, the embodiment 1 to 6 groups and the comparative example 1 to 5 groups, each group had 10 rats, and 10 normal rats were taken as the normal control group, and the corresponding samples were gavaged (the normal control group and the model group were gavaged with starch), and the gavage volume was 2.0g / kg·d for 8 consecutive weeks. Then a behavioral test was performed, namely the Morris water maze test, the water maze pool was divided into 4 quadrants, and a black platform was placed in the center of the second quadrant. The platform was circular (diameter 11cm, height 28cm), and the platform was 2cm below the water surface (called the hidden platform). A small camera was installed 2 meters above the water maze, connected to the monitor and video recorder outside the water maze, to record the escape latency time and the number of times the rat crossed the platform in the spatial exploration in the positioning navigation experiment. The positioning navigation test is to put the rat into the water from the four quadrants of the Morris water maze, and record the time it takes for the rat to find the hidden platform hidden under the water surface of the Morris water maze, which is the escape latency. After the positioning navigation, the hidden platform was removed, and the rat was placed in the pool facing the pool wall from different starting points of the four-divided pool. The swimming trajectory of the rat within 1 minute was recorded to test the rat's memory of the original platform. The results are shown in Tables 1 and 2.

[0066] Table 1 Average escape latency (s)

[0067]

[0068]

[0069] Table 2 Average number of platform crossings

[0070] Group Average number of platform crossings Normal control group 7.15±1.63 Model Group 2.46±0.75 Example 1 5.73±1.42 Example 2 5.98±1.65 Example 3 6.35±1.60 Example 4 5.62±1.51 Example 5 6.03±1.48 Example 6 6.41±1.56 Comparative Example 1 3.18±0.69 Comparative Example 2 3.29±0.71 Comparative Example 3 3.22±0.95 Comparative Example 4 3.06±0.83 Comparative Example 5 2.91±0.72

[0071] In summary, nutritional supplements for the prevention of Alzheimer's disease have shown significant improvements in the indicators for the prevention of Alzheimer's disease compared with the control group.

[0072] The links not described in detail in the present invention are all common knowledge that can be selected by ordinary technicians in the field. Although the present invention has been described in detail above with general descriptions and specific implementation schemes, it is obvious to ordinary technicians in the field that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A nutritional supplement for preventing Alzheimer's disease, characterized in that: The raw materials of the nutritional supplement for preventing Alzheimer's disease include lactitol, blueberry powder, cis-15-tetracosenoic acid, tea theanine, phosphatidylserine, sea cucumber peptide and magnesium stearate.

2. The nutritional supplement for preventing Alzheimer's disease according to claim 1, characterized in that: Measured by weight, the raw materials of the nutritional supplement for preventing Alzheimer's disease include 600-660 parts of lactitol, 180-220 parts of blueberry powder, 8-12 parts of cis-15-tetracosenoic acid, 80-100 parts of tea theanine, 28-32 parts of phosphatidylserine, 28-32 parts of sea cucumber peptide, and 8-12 parts of magnesium stearate.

3. The nutritional supplement for preventing Alzheimer's disease according to claim 2, characterized in that: In terms of weight, the raw materials of the nutritional supplement for preventing Alzheimer's disease include 630 parts of lactitol, 200 parts of blueberry powder, 10 parts of cis-15-tetracosenoic acid, 90 parts of tea theanine, 30 parts of phosphatidylserine, 30 parts of sea cucumber peptide, and 10 parts of magnesium stearate.

4. The nutritional supplement for preventing Alzheimer's disease according to claim 2, characterized in that: The cis-15-tetracosenoic acid can be fed in the form of cis-15-tetracosenoic acid microcapsules.

5. A method for preparing cis-15-tetracosenoic acid microcapsules as claimed in claim 4, characterized in that: The cis-15-tetracosenoic acid microcapsules can be obtained by the following method: 550-650 parts by weight of beta-cyclodextrin are dissolved in 5500-6500 parts by weight of distilled water to prepare a supersaturated solution, 95-105 parts of cis-15-tetracosenoic acid are added, the solution is subjected to high-speed emulsification and shearing for 3 minutes at 43-47° C. and a rotation speed of 10000-12000 r / min to obtain a final emulsion, the inlet temperature is 180° C., the outlet temperature is 80° C., and the solution is spray-dried to obtain the cis-15-tetracosenoic acid microcapsules.

6. The method for preparing cis-15-tetracosenoic acid microcapsules according to claim 5, characterized in that: The beta-cyclodextrin is 600 parts, the distilled water is 6000 parts, and the cis-15-tetracosenoic acid is 100 parts.

7. The method for preparing cis-15-tetracosenoic acid microcapsules according to claim 5, characterized in that: The emulsification temperature is 45° C. and the rotation speed is 10500 r / min.

8. A nutritional supplement according to claim 1, characterized in that: The nutritional supplement is in the form of tablets.

9. A method for preparing a tablet of a nutritional supplement for preventing Alzheimer's disease according to claim 8, characterized in that: The raw materials except magnesium stearate described in claim 4 are wet granulated, then wet granulated, passed through a 12-14 mesh sieve, dried, granulated, passed through a 16-18 mesh sieve, magnesium stearate is added to the granules, mixed evenly and then tableted.

10. Use of the nutritional supplement according to any one of claims 1 to 7 or the nutritional supplement tablet according to any one of claims 8 and 9 in the preparation of health food and other foods.

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