Valve prosthesis

Abstract

The invention relates to a valve prosthesis which comprises a support and a valve leaflet, the valve leaflet is arranged in the support, the support comprises a plurality of support rods, the support rods define a mesh structure, the mesh structure at the end of the support comprises a first mesh and a second mesh which are circumferentially arranged, a first end of the first mesh is provided with a connecting piece, and a second end of the second mesh is provided with a second end of the second mesh. The connecting piece is used for being connected with a conveyor, so that the valve prosthesis is not prone to deformation after being released.

Description

Technical Field

[0001] The present invention relates to the technical field of interventional medical equipment, and in particular to a valve prosthesis. Background Art

[0002] Heart valves are damaged by various pathogenic factors or are congenitally malformed, resulting in abnormal anatomical structure and function of one or more valves, manifested as valvular stenosis and / or insufficiency. The mitral valve and aortic valve are mainly affected (tricuspid valve and pulmonary valve are less affected), manifested as mitral stenosis (MS), mitral regurgitation (MR), aortic stenosis (AS), aortic regurgitation (AR) and combined valvular disease and other pathological types.

[0003] In the prior art, valve replacement by surgery currently tends to be performed with minimally invasive, small-incision surgery to reduce patient damage and speed up recovery. This is especially true when the original valve calcification cannot be removed, the anatomical position is poorly exposed, and the traditional surgical method has the problem of difficulty in suturing the valve. Moreover, if problems such as paravalvular leakage are found during the operation and the valve needs to be replaced again, the original sutures need to be removed carefully, which not only increases the operation time, but also increases the incidence of complications after re-suturing because the valve ring has been damaged by sutures and knots.

[0004] In recent years, transcatheter valve implantation has been increasingly used in the treatment of valvular disease. However, the valve is prone to deformation when it is released from the delivery device to the target position, which can easily lead to paravalvular leakage. Summary of the invention

[0005] The present invention aims to provide at least one valve prosthesis which is not easily deformed after release.

[0006] This purpose is achieved through the following technical solutions:

[0007] According to the technical solution of the first aspect of the present invention, a valve prosthesis is proposed, comprising a stent and a leaflet, wherein the leaflet is arranged inside the stent, the stent comprises a plurality of stent rods, the stent rods form a mesh structure, the mesh structure at the end of the stent comprises a first mesh and a second mesh arranged circumferentially, the first mesh comprises a first stent rod, a first arc and a second stent rod, a first angle is formed between the first stent rod and the second stent, the end of the first stent rod and the end of the second stent rod are connected to each other through the first arc, the first stent rod, the first arc and the second stent rod form a first end of the first mesh; the second mesh It includes a third support rod, a second arc and a fourth support rod, wherein the third support rod and the fourth support rod have a second angle, the end of the third support rod and the end of the fourth support rod are connected to each other through the second arc, the third support rod, the second arc and the fourth support rod form the first end of the second mesh, wherein the first end of the first mesh and the first end of the second mesh are both located at the end of the support, the first angle is smaller than the second angle, the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc, and the first end of the first mesh is provided with a connecting piece, and the connecting piece is used to connect a conveyor.

[0008] The above-mentioned valve prosthesis includes a first mesh and a second mesh arranged circumferentially through a mesh structure arranged at the end of the stent of the valve prosthesis, the first mesh includes a first stent rod, a first arc and a second stent rod, a first angle is formed between the first stent rod and the second stent, an end of the first stent rod and an end of the second stent rod are connected to each other through the first arc, and the first stent rod, the first arc and the second stent rod form a first end of the first mesh; the second mesh includes a third stent rod, a second arc and a fourth stent rod, a second angle is formed between the third stent rod and the fourth stent rod, an end of the third stent rod and an end of the fourth stent rod are connected to each other through the second arc, and the third stent rod, the second arc and the fourth stent rod form a first end of the second mesh, wherein In the embodiment, the first end of the first mesh and the first end of the second mesh are both located at the end of the stent, the first angle is smaller than the second angle, and the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc. Therefore, the first end of the first mesh is subjected to more concentrated force than the first end of the second mesh, and the first end of the first mesh is less likely to be circumferentially deformed than the first end of the second mesh. At this time, a connector is provided at the first end of the first mesh, and the connector is used to connect to a conveyor, so that the connector connected to the first mesh is not prone to circumferential movement when connected to the conveyor or released from the conveyor, so that the connector is guaranteed to move only in the radial direction as much as possible, thereby ensuring that the valve prosthesis is not prone to unnecessary deformation, thereby reducing the occurrence of paravalvular leakage.

[0009] Furthermore, the first arc line and the second arc line are circular arcs protruding outward from the end of the bracket.

[0010] Further, the bracket includes a first bracket segment and a second bracket segment axially connected to each other, the bracket has an inflow end and an outflow end arranged opposite to each other, the first bracket segment is close to the outflow end, the second bracket segment is close to the inflow end, the first mesh and the second mesh are arranged at the end of the first bracket segment, and the distance between the first bracket segment and the central axis of the bracket first increases and then decreases in the direction from the inflow end to the outflow end.

[0011] Furthermore, the plurality of mesh structures are connected via nodes, the first bracket segment has a plurality of first positions, the first position is a position where the distance between the first bracket segment and the central axis of the bracket is the largest, and the first position is provided with the node.

[0012] Furthermore, the first stent segment is a layer of the mesh structure, and the layer of the mesh structure is composed of the first meshes and the second meshes arranged circumferentially.

[0013] Furthermore, the first end of the first mesh is flush with the first end of the second mesh.

[0014] Further, a plurality of the first positions are located on the same circumference of the first stent segment.

[0015] Furthermore, the second support segment includes a multi-layer mesh structure, the mesh structure of the second support segment includes a third mesh, a plurality of the third meshes are circumferentially arranged to form a layer of the mesh structure, the multi-layer mesh structure is axially connected, wherein the number of the third meshes in each layer of the mesh structure is the same, and in two adjacent layers of the mesh structure, two axially adjacent third meshes are connected to each other.

[0016] Furthermore, the second support segment comprises a straight cylindrical type, and the circumferential lengths of the plurality of third meshes located on different layers are all the same; in the multi-layer mesh structure, the axial length of the third mesh located at or near the inflow end is longer than the axial length of the third mesh located at other layers, and the third mesh located at or near the inflow end comprises a fifth support rod, and the rod width of the fifth support rod is greater than the rod width of the support rod of the third mesh located at other layers.

[0017] Furthermore, the area connected to the connecting member is a connecting member supporting area, and the connecting member supporting area includes the first mesh and multiple supporting meshes, multiple supporting meshes are arranged below the first mesh, and the supporting mesh shares a part of the support rods with the first mesh, and the amount of support rods per unit area of ​​the connecting member supporting area is greater than the amount of support rods per unit area of ​​the second mesh.

[0018] Furthermore, the valve prosthesis also includes a skirt, which is arranged on the stent, and the skirt includes an inner skirt and an outer skirt that are connected to each other, the inner skirt fits the inner surface of the stent, and the edge of the outer skirt is provided with an opening, and after the outer skirt is turned outward, the opening is sutured to make the outer skirt fit the outer surface of the stent.

[0019] Furthermore, the valve prosthesis also includes a skirt, which is arranged on the bracket, and the skirt includes an inner skirt and an outer skirt that are connected to each other, the inner skirt fits the inner surface of the bracket, and the outer skirt at least completely covers the inflow end or the third mesh near the inflow end. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present invention. Moreover, the same reference numerals are used throughout the accompanying drawings to represent the same components. In the accompanying drawings:

[0021] Figure 1 It is a partial schematic diagram of a valve prosthesis provided by an embodiment.

[0022] Figure 2 This is a schematic diagram of a bracket provided by an embodiment.

[0023] Figure 3 This is a partial schematic diagram of a bracket provided in an embodiment.

[0024] Figure 4 yes Figure 3 Enlarged schematic diagram of the C area in the middle.

[0025] Figure 5 yes Figure 1 Enlarged schematic diagram of area D in the middle.

[0026] Figure 6 This is a schematic diagram of a valve prosthesis provided by an embodiment being placed into the body.

[0027] Figure 7 It is a schematic diagram of the unfolding of a skirt provided by an embodiment. DETAILED DESCRIPTION

[0028] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0029] It should be understood that the terms used herein are only for the purpose of describing specific example embodiments and are not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms "one", "an" and "said" as used herein may also be meant to include plural forms. The terms "include", "comprise", "contain", and "have" are inclusive, and therefore specify the existence of stated features, steps, operations, elements and / or parts, but do not exclude the existence or addition of one or more other features, steps, operations, elements, parts, and / or combinations thereof. The method steps, processes, and operations described herein are not interpreted as necessarily requiring them to be performed in the specific order described or illustrated, unless the execution order is clearly indicated. It should also be understood that additional or alternative steps may be used.

[0030] Although the terms first, second, third, etc. can be used in the text to describe multiple elements, components, regions, layers and / or sections, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms can only be used to distinguish an element, component, region, layer or section from another region, layer or section. Unless the context clearly indicates, terms such as "first", "second" and other numerical terms do not imply order or sequence when used in the text. Therefore, the first element, component, region, layer or section discussed below can be referred to as the second element, component, region, layer or section without departing from the teaching of the example embodiments.

[0031] For ease of description, spatial relative terms may be used herein to describe the relationship of one element or feature relative to another element or feature as shown in the figure, such as "inside", "outside", "inner side", "outer side", "below", "below", "above", "above", etc. Such spatial relative terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figure. For example, if the device in the figure is turned over, then the elements described as "below other elements or features" or "below other elements or features" will subsequently be oriented as "above other elements or features" or "above other elements or features". Therefore, the example term "below..." can include both upper and lower orientations. The device can be oriented otherwise (rotated 90 degrees or in other directions) and the spatial relative descriptors used in the text are interpreted accordingly.

[0032] It should be noted that "distal" and "proximal" are used as directional terms, which are commonly used terms in the field of interventional medical devices, where "distal" refers to the end away from the heart during surgery, and "proximal" refers to the end close to the heart during surgery. Axial refers to the direction parallel to the line connecting the distal center and the proximal center of the medical device; radial refers to the direction perpendicular to the above axial direction; circumferential refers to the direction around the outer surface of the medical device.

[0033] See also Figure 1 The present embodiment provides a valve prosthesis 100, comprising a stent 1, leaflets 2 and a skirt 3, wherein the leaflets 2 are arranged inside the stent 1, the stent 1 comprises a plurality of stent rods 11, the stent rods form a mesh structure 12, and the mesh structure 12 at the end of the stent 1 comprises a first mesh 101 and a second mesh 102 arranged circumferentially.

[0034] Combination Figure 1 , Figure 3 , Figure 4 and Figure 5The first mesh 101 includes a first support rod 1012, a first arc 1013 and a second support rod 1014, a first angle a1 is formed between the first support rod 1012 and the second support rod 1014, an end of the first support rod 1012 and an end of the second support rod 1014 are connected to each other through the first arc 1013, and the first support rod 1012, the first arc 1013 and the second support rod 1014 form a first end 1011 of the first mesh; the second mesh 102 includes a third support rod 1023, a second arc 1025 and a fourth support rod 1024, a second angle a2 is formed between the third support rod 1023 and the fourth support rod 1024, an end of the third support rod 1023 and an end of the fourth support rod 1024 are connected to each other through the second arc 1025, and the third support rod 1023, the second arc 1025 and the fourth support rod 1024 form a first end 1020 of the second mesh. Among them, the first end 1011 of the first mesh and the first end 1020 of the second mesh are both located at the end of the bracket 1, the first angle a1 is smaller than the second angle a2, the circumferential length b1 between the two ends of the first arc 1013 is smaller than the circumferential length b2 between the two ends of the second arc 1024, and the first end of the first mesh 101 is provided with a connecting piece 13, which is used to connect the conveyor.

[0035] Among them, the first angle a1 is set to be smaller than the second angle a2, and the circumferential length b1 between the two ends of the first arc 1013 is smaller than the circumferential length between the two ends of the second arc. Therefore, the first end 1011 of the first mesh is subjected to more concentrated force than the first end 1020 of the second mesh, and the first end 1011 of the first mesh is less likely to be circumferentially deformed than the first end 1020 of the second mesh. At this time, a connector 13 is provided at the first end of the first mesh 101, and the connector 13 is used to connect the conveyor, so that the connector 13 connected to the first mesh 101 is not prone to circumferential movement when connected to the conveyor or released from the conveyor, so that the connector 13 is guaranteed to move only in the radial direction as much as possible, so as to ensure that the valve prosthesis 100 is not prone to unnecessary deformation, thereby reducing the occurrence of paravalvular leakage.

[0036] In this embodiment, the first arc 1013 and the second arc 1025 are arcs protruding outward from the end of the bracket 1, which can be more smoothly received into the conveyor without scratching the inside of the conveyor. In other embodiments, the first arc 1013 and the second arc 1025 can also be arcs protruding toward the inside of the bracket 1.

[0037] See also Figure 2 and Figure 3 In this embodiment, the maximum length of the first mesh 101 in the circumferential direction is smaller than the maximum length of the second mesh 102 in the circumferential direction; or / and, the maximum length of the first mesh 101 in the axial direction is smaller than the maximum length of the second mesh 102 in the axial direction.

[0038] In this embodiment, combined with Figure 1 , the area connected to the connector 13 is the connector support area P, the connector support area P includes a first mesh 101 and a plurality of support meshes 104, a plurality of support meshes 104 are arranged on the side of the first mesh 101 away from the connector 13, the support mesh 104 and the first mesh 101 can share a part of the support rod, the amount of support rods per unit area of ​​the connector support area P is greater than the amount of support rods per unit area of ​​the second mesh 102, so that the radial support force of the connector support area P is greater than the radial support force of the second mesh 102. The amount of support rods here can be the sum of the lengths of the support rods, the sum of the volumes of the support rods, or the sum of the number of support rods, as long as the radial support force of the connector support area P can be greater than the radial support force of the second mesh 102.

[0039] In this embodiment, by providing a connecting member support area P including a first mesh 101 and a plurality of supporting meshes 104, the connecting member 13 connected to the first mesh 101 is not likely to move circumferentially when connected to or released from the conveyor. Figure 1 The middle connector 13 is not prone to swaying left and right, thereby ensuring that the valve prosthesis 100 is not prone to unnecessary deformation, thereby reducing paravalvular leakage caused by poor release position of the valve prosthesis 100. In addition, the number of stent rods per unit area of ​​the second mesh 102 is small, which can make the second mesh 102 more free and not easily affected by the force of the first mesh 101. Specifically, in the process from non-release to semi-release, the connector 13 is still connected to the conveyor, the first mesh 101 connected to the connector 13 has not been fully released, and the second mesh 102 has basically been released. When in the process from semi-release to full release, the connector 13 is released from the conveyor, causing the first mesh 101 connected to the connector 13 to radially bounce outward, which easily drives the second mesh 102 circumferentially connected to the first mesh 101 to also experience a corresponding force, thereby causing the stent as a whole to bounce and produce an unexpected displacement of the valve prosthesis. At this time, the amount of stent rods per unit area of ​​the second mesh 102 is relatively small, which can make the second mesh 102 have a greater degree of freedom and is not easily affected by the force of the first mesh 101, which can greatly reduce the unexpected displacement of the valve prosthesis and improve the release stability of the valve prosthesis.

[0040] Among them, the stent 1 has an inflow end A and an outflow end B that are relatively arranged. The end of the stent 1 can refer to the inflow end A. At this time, the surgical procedure adopted is transapical release of the valve prosthesis. The end of the stent 1 can also refer to the inflow end B. At this time, the surgical procedure adopted is transaortic release of the valve prosthesis.

[0041] See also Figure 3In this embodiment, the stent 1 includes a first stent segment L1 and a second stent segment L2 which are axially connected to each other. The first stent segment L1 is close to the outflow end B, and the second stent segment L2 is close to the inflow end A. The end of the first stent segment L1 is provided with a first mesh 101 and a second mesh 102. The distance between the first stent segment L1 and the central axis O of the stent increases first and then decreases from the inflow end A to the outflow end B.

[0042] That is, in this embodiment, the portion 110 of the first stent segment L1 near the outflow end B extends toward the central axis O, which can conveniently guide the valve prosthesis 100 into the conveyor. The portion 120 of the first stent segment L1 near the inflow end A also extends toward the central axis O, and then connects with the second stent segment L2. The second stent segment L2 includes a concave section 130, which is close to the outflow end B. The concave section 130 is smoothly connected to the portion 120 of the first stent segment L1 near the inflow end A. The concave section 130 can avoid occluding the coronary artery and does not affect the circulation of coronary blood.

[0043] In this embodiment, multiple mesh structures are connected by nodes, and the first stent segment L1 has multiple first positions 140, and the first position 140 is the position where the distance between the first stent segment L1 and the central axis O of the stent is the largest, and the first position 140 is provided with a node 1401. That is to say, the node 1401 is provided at the position where the first stent segment L1 protrudes radially outward the farthest, so that the radial support force at the position in contact with and supporting the inner wall of the tissue is the largest, and the deformation of the stent 1 when disturbed by hard objects such as plaques is avoided, thereby causing paravalvular leakage. In this embodiment, multiple first positions 140 can be located on the same circumference of the first stent segment L1, and at this time, multiple nodes 1401 are located on the same circumference of the first stent segment L1 to ensure the central symmetry of the first stent segment L1, so that the stent 1 can be implanted in the body in a more suitable and better controlled state. In other embodiments, multiple first positions 140 can be located on different circumferences of the first stent segment L1.

[0044] In this embodiment, the first stent segment L1 is a mesh structure, which is composed of a first mesh 101 and a second mesh 102 arranged circumferentially. At this time, the mesh structure area of ​​the first stent segment L1 is large, the radial support force of the first stent segment L1 is small, and the first stent segment L1 is relatively soft as a whole, so that the first stent segment L1 can better fit the inner wall of the tissue. In addition, combined with Figure 3 and Figure 6Since the first stent segment L1 has only one layer of mesh structure, the portion 120 of the first stent segment L1 near the inflow end A extends toward the central axis O, that is, the first mesh 101 and the second mesh 102 near the inflow end A are recessed toward the central axis O, so that the second mesh 102 can be interconnected with the coronary artery 200. Since the area of ​​the second mesh 102 is large enough, after the valve prosthesis 100 is implanted, the coronary artery 200 can be subjected to relevant surgical operations through the second mesh 102 without affecting the implanted valve prosthesis 100. In other embodiments, the first stent segment L1 may have a multi-layer mesh structure.

[0045] exist Figure 3 In the embodiment, the first end 1011 of the first mesh 101 connected to the connector is flush with the first end 1020 of the second mesh 102, that is, they are located on the same straight line N, so as to avoid problems affecting the assembly effect and efficiency and the phenomenon of backflow. Under the premise of ensuring that the first position 140 is provided with a node 1401, if the first end 1020 of the second mesh 102 is lower than the first end 1011 of the first mesh 101 connected to the connector, the portion of the second mesh 102 close to the outflow end B is shorter, that is, the portion 110 of the first stent segment L1 close to the outflow end B is shorter, and the portion 110 of the first stent segment L1 close to the outflow end B is shorter in the direction of the central axis O, so that the guide section of the valve prosthesis 100 in the conveyor is shorter, so that the valve prosthesis 100 is not smoothly collected in the conveyor, which affects the assembly effect and efficiency; if the first end 1020 of the second mesh 102 is higher than The first mesh 101 is connected to the first end 1011 of the connector, and the length of the first stent segment L1 will become longer. However, under the premise that the length of the stent 1 remains unchanged, in order to ensure that the fixing effect of the valve prosthesis 100 is not affected and paravalvular leakage does not occur, the length of the inflow channel M of the stent 1 (referring to the distance between the lowest edge of the leaflet and the inflow end A of the stent) cannot be reduced. Since the leaflet angle 21 is already at the top, the axial length of the leaflet 2 on the stent 1 will be shortened due to the increase in the length of the first stent segment L1, which will affect the fit between the multiple leaflets, and then lead to incomplete closure between the leaflets, resulting in reflux.

[0046] See also Figure 3The second stent segment L2 includes a multi-layer mesh structure, the mesh structure of the second stent segment L2 includes a third mesh 103, a plurality of third meshes 103 are arranged circumferentially to form a layer of mesh structures 201, 202, 203, the multi-layer mesh structures are axially connected, wherein the number of third meshes 103 in each layer of mesh structures 201, 202, 203 is the same, and in two adjacent layers of mesh structures, two axially adjacent third meshes are connected to each other. Such a design can make the axial force transmission of the second stent segment L2 more uniform, and thus make the valve prosthesis 100 more stable as a whole during the process of receiving the valve prosthesis 100 into the conveyor and releasing it from the conveyor, and it is not easy to deform or shift.

[0047] The second stent segment L2 includes a straight-cylindrical type, which is substantially straight-cylindrical, and has a concave section 130 at a position of the second stent segment L2 near the outflow end B. Compared with the second stent segment L2 which is substantially tapered, the tapered shape is that the diameter of the second stent segment L2 gradually decreases from the inflow end A to the outflow end B. In vivo, due to the backflow of blood flow, this tapered shape easily weakens the fixing performance of the valve prosthesis 100 and makes it easy to slip into the heart.

[0048] Specifically, the lengths of the third meshes 103 located on different layers are all the same in the circumferential direction. In the multi-layer mesh structure, the axial length of the third mesh 103 located at the inflow end A or near the inflow end A is longer than the axial length of the third mesh 103 located at other layers. Further, the axial length of the multi-layer mesh structure can gradually decrease from the inflow end A to the outflow end B. That is, the axial lengths of a layer of mesh structure 201, a layer of mesh structure 202, and a layer of mesh structure 203 gradually decrease from the inflow end A to the outflow end B. In addition, the third mesh located at the inflow end A or near the inflow end A (that is, the mesh structure 201) includes a fifth support rod 2011, and the rod width of the fifth support rod 2011 is greater than the rod width of the support rods (such as the sixth support rod 2021 and the seventh support rod 2031) of the third mesh located at other layers (such as the mesh structures 202 and 203). The mesh structure 202 includes a sixth support rod 2021, and the mesh structure 203 includes a seventh support rod 2031. With such a design, the third mesh located at or near the inflow end A, that is, the mesh structure 201, has a longer axial length, which can ensure a longer fitting length with the valve ring and avoid paravalvular leakage. At the same time, its rod width is also larger, thereby increasing its radial support force, which is used to better fix it at the valve ring and improve the fixation performance of the entire valve prosthesis. Further, the radial support force of the mesh structure 203 is greater than the radial support force of the mesh structure 202. For example, in this embodiment, the axial length of the mesh structure 203 is set to be smaller than the axial length of the mesh structure 202, wherein the mesh structure 203 on the stent 1 is located close to the free end of the native leaflet, so that a larger radial support force is required to open the free end of the native leaflet, thereby achieving better fixation of the valve prosthesis.

[0049] In this embodiment, the second bracket segment L2 has three layers of mesh structures 201, 202, and 203, one end of some third meshes 103 in the third layer of mesh structure 203 is connected to the second end 1010 of the first mesh 101, and the first end 1011 of the first mesh 101 is connected to the connector 13. In the third layer of mesh structure 203, one end of adjacent third meshes 103 extends a bracket rod 1021 and a bracket rod 1022, respectively, and the bracket rod 1021 and the bracket rod 1022 extend a bracket rod 1024 and a bracket rod 1023, respectively, and the bracket rod 1024 and the bracket rod 1023 converge to form a point, thereby forming the second mesh 102. That is, the second mesh 102 is enclosed by two bracket rods of the adjacent third mesh 103, the bracket rod 1021, the bracket rod 1022, the bracket rod 1024, and the bracket rod 1023. In other embodiments, the second bracket segment L2 may have a multi-layer mesh structure.

[0050] In this embodiment, the radial force of the first stent segment L1 is smaller than the radial force of the second stent segment L2. The radial force of the first stent segment L1 is relatively small, which can better fit the inner wall of the tissue, adapt to different in vivo environments, and is easier to be received in the conveyor. The radial force of the second stent segment L2 is relatively large, which can reduce the leaflet connected thereto to be more stable and not easy to deform.

[0051] See also Figure 7 The valve prosthesis 100 further includes a skirt 3, which is arranged on the stent 1. The skirt 3 includes an inner skirt 31 and an outer skirt 32 which are connected to each other. The inner skirt 31 fits the inner surface of the stent 1. The edge 320 of the outer skirt 32 is provided with a plurality of openings 321, so as to facilitate the outer skirt 32 to be everted. After the outer skirt 32 is everted, the openings 321 are sutured to make the outer skirt 32 fit the outer surface of the stent 1 more closely. In this embodiment, the edge 320 of the outer skirt 32 is generally serrated to facilitate suturing on the stent rod, and the edge 320 has a plurality of trapezoidal grooves; the openings 321 are formed by the bottom of the trapezoidal grooves being concave toward the inner skirt 31, and are V-shaped. In other embodiments, the openings 321 may also be W-shaped, U-shaped, etc., as long as they can make the outer skirt 32 fit the outer surface of the stent 1 more closely. In this embodiment, the outer skirt 32 at least completely covers the mesh structure 201. Since the mesh structure 201 is placed at the valve annulus, paravalvular leakage can be prevented from occurring at the valve annulus.

[0052] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A valve prosthesis, comprising a stent and a leaflet, wherein the leaflet is arranged inside the stent, the stent comprises a plurality of stent rods, and the stent rods form a mesh structure, characterized in that: The mesh structure at the end of the stent includes a first mesh and a second mesh arranged circumferentially, The first mesh includes a first support rod, a first arc and a second support rod, a first angle is formed between the first support rod and the second support rod, an end of the first support rod and an end of the second support rod are connected to each other through the first arc, and the first support rod, the first arc and the second support rod form a first end of the first mesh; the second mesh includes a third support rod, a second arc and a fourth support rod, a second angle is formed between the third support rod and the fourth support rod, an end of the third support rod and an end of the fourth support rod are connected to each other through the second arc, and the third support rod, the second arc and the fourth support rod form a first end of the second mesh, Wherein, the first end of the first mesh and the first end of the second mesh are both located at the end of the bracket, the first angle is smaller than the second angle, the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc, and the first end of the first mesh is provided with a connecting piece, and the connecting piece is used to connect a conveyor.

2. The valve prosthesis according to claim 1, characterized in that: The first arc line and the second arc line are circular arcs protruding outward from the end of the bracket.

3. The valve prosthesis according to claim 1, characterized in that: The stent includes a first stent segment and a second stent segment axially connected to each other, the stent has an inflow end and an outflow end arranged opposite to each other, the first stent segment is close to the outflow end, the second stent segment is close to the inflow end, the first mesh and the second mesh are arranged at the end of the first stent segment, and the distance between the first stent segment and the central axis of the stent first increases and then decreases in the direction from the inflow end to the outflow end.

4. The valve prosthesis according to claim 3, characterized in that: The plurality of mesh structures are connected via nodes, the first bracket segment has a plurality of first positions, the first position being a position where the distance between the first bracket segment and the central axis of the bracket is the largest, and the first position is provided with the node.

5. The valve prosthesis according to claim 4, characterized in that: The first stent segment is a layer of the mesh structure, and the layer of the mesh structure is composed of the first meshes and the second meshes arranged circumferentially.

6. The valve prosthesis according to claim 5, characterized in that: The first end of the first mesh is flush with the first end of the second mesh.

7. The valve prosthesis according to claim 4, characterized in that: The plurality of first positions are located on the same circumference of the first stent segment.

8. The valve prosthesis according to claim 3, characterized in that: The second bracket segment includes a multi-layer mesh structure, and the mesh structure of the second bracket segment includes a third mesh. A plurality of the third meshes are circumferentially arranged to form a layer of the mesh structure. The multi-layer mesh structures are axially connected, wherein the number of the third meshes in each layer of the mesh structure is the same, and in two adjacent layers of the mesh structure, two axially adjacent third meshes are connected to each other.

9. The valve prosthesis according to claim 8, characterized in that: The second support segment comprises a straight cylinder type, and the circumferential lengths of the plurality of third meshes located on different layers are all the same. In the multi-layer mesh structure, the axial lengths of the third meshes located at or near the inflow end are longer than the axial lengths of the third meshes located at other layers, and the third meshes located at or near the inflow end comprise a fifth support rod, and the rod width of the fifth support rod is greater than the rod width of the support rods of the third meshes located at other layers.

10. The valve prosthesis according to claim 1, characterized in that: The area connected to the connecting member is a connecting member support area, and the connecting member support area includes the first mesh and multiple supporting meshes. Multiple supporting meshes are arranged on the side of the first mesh away from the connecting member, and the amount of support rods per unit area of ​​the connecting member support area is greater than the amount of support rods per unit area of ​​the second mesh.

11. The valve prosthesis according to claim 1, characterized in that: The valve prosthesis also includes a skirt, which is arranged on the bracket. The skirt includes an inner skirt and an outer skirt that are connected to each other. The inner skirt fits the inner surface of the bracket, and the edge of the outer skirt is provided with an opening. After the outer skirt is turned outward, the opening is sutured to make the outer skirt fit the outer surface of the bracket.

12. The valve prosthesis according to claim 9, characterized in that: The valve prosthesis also includes a skirt, which is arranged on the bracket, and includes an inner skirt and an outer skirt connected to each other, the inner skirt fits the inner surface of the bracket, and the outer skirt at least completely covers the inflow end or the third mesh near the inflow end.

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