Long-acting waterproof mosquito-repellent emulsion and preparation method thereof

Abstract

The invention belongs to the field of daily chemical products, and particularly relates to a long-acting waterproof mosquito-repellent emulsion and a preparation method thereof. The mosquito-repelling emulsion comprises a mosquito-repelling active substance, an emulsifier, a humectant, a thickener, a slow-release agent, a waterproof material, a preservative and water. The mosquito-repelling emulsion can achieve a long-acting mosquito-repelling effect, has waterproof and seawater-proof functions, and is particularly suitable for being used in wading and sweating environments such as coastal areas, marshes and rainforests.

Description

Technical Field

[0001] The invention belongs to the field of daily chemical products, and particularly relates to a long-acting waterproof mosquito repellent emulsion and a preparation method thereof. Background Art

[0002] In summer, with high temperature and high humidity, mosquitoes and blood-sucking midges are causing serious harm. Common mosquitoes such as Aedes aegypti, Aedes albopictus, Culex pipiens, etc. are widely distributed in my country and have strong attack power. On the one hand, they bring uncomfortable symptoms such as itching and pain, which seriously disturb people's normal life. On the other hand, they can also spread mosquito-borne infectious diseases such as dengue fever. People's indoor and outdoor activities are inseparable from various mosquito repellent products.

[0003] There are many types of mosquito repellent products on the market, such as mosquito repellent floral water, mosquito repellent ointment, mosquito repellent bracelets, etc., but few of these products are waterproof. Summary of the invention

[0004] The purpose of the present invention is to provide a long-acting waterproof mosquito repellent emulsion and a preparation method thereof, so as to solve the shortcomings of existing mosquito repellent products such as short mosquito repellent time and no waterproof function.

[0005] The long-lasting waterproof mosquito repellent lotion of the present invention can repel mosquitoes for a long time through the slow release effect of the polymer material, and has a waterproof effect. It is found in actual use that it also has a certain antipruritic effect. Moreover, it can be directly washed off with water under artificial mechanical factors, which is very convenient.

[0006] To achieve the above object, the present invention adopts the following technical solution:

[0007] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of weight percentages is 100%, the mosquito repellent emulsion comprises the following components and their contents:

[0008]

[0009] The mosquito repellent active substance is a chemical source substance or a plant source substance;

[0010] The chemical source substance is selected from any one or more of DEET, Imonim, Icaridin, Permethrin, and Eugenol;

[0011] The plant-derived substance is selected from any one or more of citronella oil, cinnamon oil, eucalyptus oil, camphor oil, lemon eucalyptus oil, peppermint oil, citronellol, citronellal, geraniol, linalool, citronellol alcohol, and cinnamaldehyde;

[0012] The emulsifier is selected from any one or more of OP-9, OP-10, OP-50, cetyl phosphate, polyethylene glycol 400, sorbitan monostearate (Span-60), monoglyceride of fatty acid, and Tween-80;

[0013] The moisturizer is selected from any one or more of glycerin, erythritol, sorbitol, xylitol, butylene glycol, vaseline (such as white vaseline), white mineral oil, liquid paraffin, squalane, hyaluronic acid, and jojoba oil;

[0014] The thickener is selected from: any one or more of carboxymethyl cellulose, cellulose ether, PEG-150 distearate, polyacrylamide, carbomer 934, carbomer 941, and carbomer 940;

[0015] The sustained-release agent is selected from natural polymer sustained-release materials or synthetic polymer sustained-release materials;

[0016] The natural polymer sustained-release material is selected from any one or more of xanthan gum, gelatin, gum arabic, and chitosan;

[0017] The synthetic polymer sustained-release material is selected from any one or more of cross-linked polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyacrylic acid resin, acrylic acid resin, and polyacrylate;

[0018] The waterproof material is selected from: any one or more of polyvinyl pyrrolidone, polyvinyl alcohol, hydroxyethyl cellulose, and methyl cellulose;

[0019] The preservative is selected from any one or more of methylisothiazolinone, paraben, methylparaben, benzyl alcohol, sorbic acid, caprylhydroxamic acid, benzoic acid, sodium benzoate, sodium chloride, and disodium EDTA.

[0020] Preferably, the mosquito repellent emulsion comprises the following components and their contents:

[0021]

[0022] Preferably, the mosquito repellent active substance is selected from any one or more of DEET, Imonim, Icaridin, eugenol, citronella oil, eucalyptus oil, lemon eucalyptus oil, peppermint oil, citronellol, citronellol alcohol, and cinnamaldehyde;

[0023] The emulsifier is selected from any one or more of cetyl phosphate, polyethylene glycol 400, Span-60, monoglyceride, and Tween-80;

[0024] The moisturizer is selected from any one or more of glycerin, vaseline (such as white vaseline), liquid paraffin, squalane, and hyaluronic acid;

[0025] The thickener is selected from: any one or more of Carbomer 934, Carbomer 941, and Carbomer 940;

[0026] The sustained-release agent is selected from any one or more of xanthan gum, gelatin, gum arabic, and acrylic resin;

[0027] The waterproof material is selected from: any one or more of polyvinyl pyrrolidone, polyvinyl alcohol, and methyl cellulose;

[0028] The preservative is selected from any one or more of benzyl alcohol, sorbic acid, benzoic acid, sodium benzoate, sodium chloride, and disodium EDTA.

[0029] Further preferably, the mosquito repellent emulsion comprises the following components and their contents:

[0030]

[0031]

[0032] Further preferably, the mosquito repellent active substance is selected from any one or more of DEET, Imonim, Icaridin, Eugenol, Citrin, Geraniol;

[0033] The emulsifier is selected from: any one or more of Span-60 and monoglyceride of fatty acid;

[0034] The moisturizer is selected from: any one or more of glycerin and liquid paraffin;

[0035] The thickener is selected from: any one or more of Carbomer 941 and Carbomer 940;

[0036] The sustained-release agent is selected from: gelatin;

[0037] The waterproof material is selected from: polyvinyl pyrrolidone;

[0038] The preservative is selected from any one or more of sodium benzoate, disodium EDTA, and sodium chloride.

[0039] Further preferably, the mosquito repellent emulsion comprises the following components and their contents:

[0040]

[0041] Further preferably, the mosquito repellent active substance is any one or more of DEET, Imonim, Icaridin, and Citral;

[0042] The emulsifier is: Span-60 (for example, the content is 3% to 4%, preferably 3.5%) and monoglyceride of fatty acid (for example, the content is 1.5% to 2.5%, preferably 2%);

[0043] The oil phase moisturizer is glycerin; the water phase moisturizer is liquid paraffin;

[0044] The thickener is: Carbomer 941;

[0045] The sustained-release agent is: gelatin;

[0046] The waterproof material is: polyvinyl pyrrolidone;

[0047] The preservative is sodium benzoate.

[0048] In a specific embodiment, the mosquito repellent emulsion comprises the following components and their contents:

[0049]

[0050] The mosquito repellent emulsion of the present invention has water-proof and / or seawater-proof properties.

[0051] The effective protection time of the mosquito repellent emulsion is greater than 6 hours, preferably greater than 6.5 hours, more preferably greater than 6.7 hours, more preferably greater than 7 hours, more preferably greater than 8 hours, and more preferably greater than 8.5 hours.

[0052] The present invention also provides a method for preparing the long-acting waterproof mosquito repellent emulsion, which comprises the following steps:

[0053] (1) Stirring the sustained-release agent and the thickener in appropriate amount of water respectively and leaving them to stand to form a clear uniform solution of the sustained-release agent and the thickener;

[0054] (2) dissolving the waterproof material in an appropriate amount of water and stirring evenly, adding a moisturizer (aqueous phase), and then adding a preheated uniform solution of a sustained-release agent and a uniform solution of a thickener, stirring evenly at an appropriate temperature to obtain a mixture A;

[0055] (3) heating the emulsifier and moisturizer (oil phase) until they become liquid, adding them to the mixture A, and stirring them evenly to obtain a mixture B;

[0056] (4) adding the preservative and the mosquito repellent active substance to the mixture B at a suitable temperature, adding water to the full amount, and stirring evenly to obtain the long-acting waterproof mosquito repellent emulsion.

[0057] Wherein, in step (2), the preheating temperature is 65-90°C, the stirring speed is 200-600 r / min, and the stirring time is 20-40 min; in step (3), the heating temperature is 65-85°C, the stirring speed is 800-1500 r / min, and the stirring time is 10-30 min; in step (4), the suitable temperature is 45-55°C, the stirring speed is 2000-3000 r / min, and the stirring time is 20-40 min.

[0058] Preferably, in step (2), the preheating temperature is 70-80°C, the stirring speed is 300-500 r / min, and the stirring time is 25-35 min; in step (3), the heating temperature is 75-80°C, the stirring speed is 1000-1500 r / min, and the stirring time is 15-25 min; in step (4), the suitable temperature is 45-50°C, the stirring speed is 2200-2800 r / min, and the stirring time is 15-30 min.

[0059] More preferably, in step (2), the preheating temperature is 70°C, the stirring speed is 300-400 r / min, and the stirring time is 30 min; in step (3), the heating temperature is 80°C, the stirring speed is 1100-1300 r / min, and the stirring time is 20 min; in step (4), the suitable temperature is 45°C, the stirring speed is 2400-2500 r / min, and the stirring time is 30 min.

[0060] The beneficial effects of the present invention are:

[0061] The long-acting waterproof mosquito repellent emulsion provided by the present invention can obviously achieve a long-acting mosquito repellent effect, and has waterproof and seawater-proof functions, and is suitable for use in wading and sweating environments such as coastal areas, swamps, and rain forests.

[0062] Compared with creams, the present invention prepares mosquito repellent active substances such as DEET, Imonene, Icaridin, eugenol, citronella oil, eucalyptus oil, lemon eucalyptus oil, peppermint oil, citronellol, citronellol, cinnamaldehyde, etc. into emulsions, which have the advantages of easy application, good comfort, and skin moisturizing.

[0063] The long-acting waterproof mosquito repellent emulsion of the invention has simple preparation process, low equipment requirements, low cost and is suitable for industrial large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0064] Figure 1A The waterproof performance test results of the mosquito repellent emulsion prepared in Example 1 of the present invention are shown.

[0065] Figure 1B The following are the test results of the waterproof performance of the mosquito repellent emulsions of the comparative examples.

[0066] Figure 2A The results are as follows: the anti-seawater performance test results of the mosquito repellent emulsion prepared in Example 1 of the present invention.

[0067] Figure 2B The following are the results of the seawater resistance test of the mosquito repellent emulsions of the comparative examples. DETAILED DESCRIPTION

[0068] In order to make the contents of the present invention easier to understand, the technical solutions of the present invention are further described below in conjunction with specific implementation methods.

[0069] Preparation Example 1

[0070] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0071]

[0072] The preparation method of the mosquito repellent emulsion comprises the following steps:

[0073] Take the formula amount of sustained-release gelatin and thickener carbomer 941, add appropriate amount of water and stir evenly, and let stand at room temperature until a transparent uniform solution is formed; take the formula amount of waterproof material polyvinyl pyrrolidone, dissolve it in appropriate amount of water at 70°C, take the formula amount of aqueous phase moisturizing agent glycerin, and add the prepared gelatin uniform solution (preheated at 70°C) and carbomer 941 uniform solution, stir at 70°C and 300r / min for 30min until uniform, to obtain solution A; add the formula amount of emulsifier Span-6 0 and monostearate glyceryl and oil phase moisturizer liquid paraffin are heated at 80°C until they become a clear liquid, and solution A is added, and stirred at 1100r / min at 80°C for 20min until the solution is white and uniform, to obtain solution B; the formula amount of preservative sodium benzoate and mosquito repellent active substance DEET are added to solution B at 45°C (preliminarily left to stand at room temperature to cool to 45°C), water is added to the full amount, and stirred at 2500r / min for 30min until the solution is white and uniform, to obtain the long-acting waterproof mosquito repellent emulsion.

[0074] Preparation Example 2

[0075] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0076]

[0077] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0078] Preparation Example 3

[0079] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0080]

[0081] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0082] Preparation Example 4

[0083] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0084]

[0085]

[0086] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0087] Preparation Example 5

[0088] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0089]

[0090] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0091] Preparation Example 6

[0092] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0093]

[0094] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0095] Preparation Example 7

[0096] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0097]

[0098] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0099] Preparation Example 8

[0100] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0101]

[0102] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0103] Preparation Example 9

[0104] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0105]

[0106]

[0107] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0108] Preparation Example 10

[0109] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0110]

[0111] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0112] Preparation Example 11

[0113] A long-lasting waterproof mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0114]

[0115]

[0116] A mosquito repellent emulsion was prepared in the same manner as in Preparation Example 1 except that the above components were used.

[0117] Comparative Examples

[0118] A mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises:

[0119] DEET 10%, 2800B 5%, Macrogol 400 2%, Xanthan Gum 0.5%, PVPK30 2%, Propylene Glycol 2%, Sodium Benzoate 0.2%, Water balance.

[0120] The preparation method of the mosquito repellent emulsion comprises the following steps:

[0121] Take a formula amount of xanthan gum, add an appropriate amount of water and stir evenly, let it stand at room temperature to fully swell and form a uniform solution; take a formula amount of PVPK30, dissolve it in an appropriate amount of water at 80°C, take a formula amount of propylene glycol, and mix it into the prepared xanthan gum uniform solution (preheated at 80°C), stir at 300r / min at 80°C for 30min until it is uniform, and obtain solution A; heat the formula amount of 2800B and polyethylene glycol 400 at 80°C until they become clear liquids, mix them into solution A, stir at 1100r / min at 80°C for 20min until it is white and uniform, and obtain solution B; take a formula amount of sodium benzoate and DEET, add them to solution B (pre-cooled to 45°C) at 45°C, add water to the full amount, stir at 2500r / min for 30min until it is white and uniform, and obtain the mosquito repellent emulsion.

[0122] Test Example 1: Determination of repellent activity of repellent active substances

[0123] The repellent activity of mosquito repellent active substances on female adults of Aedes albopictus was determined using a "Y" type olfactometer. Each time, the reaction of 20 female mosquitoes to the active substances was measured. A microinjector was used to draw 5 μL of active substances onto a filter paper strip and put it into one chamber. A filter paper strip of the same size without active substances was placed in the other chamber as a control. The timing was started. After 20 seconds, 20 female mosquitoes were put into the insect injection port. The number of mosquitoes in the two-arm tubes at 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 minutes was recorded respectively. Each active substance was repeated 3 times. It has been proven in the early stage that the two-arm tube has no tendency effect on mosquitoes.

[0124] Repellency rate (%) calculation formula: PR% = (Nc-Nt) / (Nc+Nt)×100%

[0125] Where: Nc represents the number of mosquitoes in the control arm, and Nt represents the number of mosquitoes in the treatment group.

[0126] Table 1 Results of determination of repellent activity of repellent active substances

[0127]

[0128] From the repellent activity test results of the repellent active substances in Table 1, it can be seen that the best repellent active substance for female adult Aedes albopictus is Imonin, followed by DEET and Icaridin. The repellent activity of plant-derived repellent active substances is relatively poor overall, but the repellent activity of eucalyptol is relatively good. Therefore, DEET, Imonin, Icaridin and eucalyptol are given priority as active substances in the subsequent preparation of mosquito repellent emulsions.

[0129] Test Example 2: Waterproof Performance Test

[0130] Test drugs: the long-acting waterproof mosquito repellent emulsion prepared in Preparation Example 1 and the mosquito repellent emulsion prepared in Comparative Example.

[0131] (1) Waterproof performance evaluation

[0132] According to the requirements of the "China 2015 Cosmetic Safety Technical Specifications", the waterproof performance was evaluated by cutting a 3MTRANSPOREMT porous film (3 cm × 2 cm) and applying the test sample evenly on the film (1 mg cm -2 ), put the film coated with the sample in a 32℃ oven (simulating the human body surface temperature of 32℃), keep it warm for 15min, then immerse the film in a 32℃ physiological sodium chloride solution at 100r·min -1 Stir at high speed. After soaking for 30 minutes, wash the residual sample on the film with acetonitrile and dilute to a certain volume as the test group. Use the HPLC method established earlier to determine the content of active substances in the test group. In the same way, take the same test sample and operate it according to the above method, but do not immerse it in 32°C physiological sodium chloride solution. Determine the residual amount of active substances on the film that has not been treated with water as the control group. Content ratio (%) = test group / control group × 100%. See the results. Figure 1A and Figure 1B .

[0133] Figure 1A The film of the sample of Preparation Example 1 was applied, and all the samples adhered to the 3M sealing film, and there was no white flocculent in the water; Figure 1B The film of the comparative example sample was coated, and most of the sample did not adhere to the 3M sealing film, and there were obvious white floccules in the water. The results show that the mosquito repellent emulsion of the present invention has better waterproof performance.

[0134] (2) Evaluation of seawater resistance

[0135] According to the requirements of the "China 2015 Cosmetic Safety Technical Specifications", the waterproof performance was evaluated by cutting a 3MTRANSPOREMT porous film (3 cm × 2 cm) and applying the test sample evenly on the film (1 mg cm -2 ), the film coated with the sample was placed in a 32°C oven (simulating the human body surface temperature of 32°C), kept warm for 15 minutes, and then immersed in a 32°C simulated seawater solution at 100 r·min -1 Stir at high speed. After soaking for 30 minutes, wash the residual sample on the film with acetonitrile and dilute to a certain volume as the test group. Use the HPLC method established earlier to determine the content of active substances in the test group. In the same way, take the same test sample and operate it according to the above method, but do not immerse it in a 32°C simulated seawater solution. Determine the residual amount of active substances on the film that has not been treated with water as the control group. Content ratio (%) = test group / control group × 100%. See the results. Figure 2A and Figure 2B .

[0136] Figure 2AThe film of the sample of Preparation Example 1 was applied, and all the samples adhered to the 3M sealing film, and there was no white flocculent in the water; Figure 2B The film of the comparative example sample was coated, and most of the sample did not adhere to the 3M sealing film, and there were obvious white floccules in the water. The results show that the mosquito repellent emulsion of the present invention has better seawater resistance.

[0137] Test Example 3: Stability Test

[0138] According to the national new drug stability evaluation index, the mosquito repellent emulsion prepared in Example 1-11 was subjected to stability test. The centrifugal test included: taking a sample and centrifuging it at 2500 r / min. -1 Centrifuge for 30 minutes and observe whether there is oil-water separation or other property changes. High (low) temperature resistance test: Take a sample and place it at -20°C or 32°C for 72 hours to observe whether there is oil-water separation or other property changes. The results show that the mosquito repellent emulsions prepared in Preparation Examples 1-11 of the present invention are stable in nature.

[0139] Test Example 4: Determination of repellent activity against Aedes albopictus

[0140] According to the requirements of Part 9 of "Indoor Efficacy Test and Evaluation of Public Health Insecticides for Pesticide Registration": Repellent GB / T13917.9-2009, the indoor efficacy test method and evaluation standard of repellent shall be carried out.

[0141] Select 4 or more testers with qualified attack power (half male and half female, and should not drink alcohol, tea or coffee before and during the test, and should not use products containing fragrances) and draw a 50mm×50mm skin area on the back of each hand. Press 15mg / cm on one hand. 2 Evenly apply the repellent to be tested with a dose of (paste repellent), exposing 40mm×40mm of the skin, and tightly covering the rest. The other hand is a blank control. Apply the repellent for 2 hours, put the hand into a mosquito cage with qualified attack power for 2 minutes, and observe whether there are mosquitoes coming to land and suck blood. After that, test once every 1 hour. As long as there is one mosquito coming to suck blood, the repellent is considered ineffective. Record the effective protection time (h) of the repellent. Each time, a control test is performed on the control hand first. Test insects with qualified attack power can continue to be tested. If the attack power of the test insects is unqualified, qualified test insects must be replaced for testing. The control substances are commercially available mosquito repellent milk containing 20% ​​icaridin and commercially available mosquito repellent liquid containing 9% DEET.

[0142] The effective protection time of the drug for more than 4 subjects is added up, and the average (retain one decimal place) is taken as the effective protection time (h) of the drug.

[0143] The efficacy of the repellent is evaluated based on the effective protection (h) of the test personnel. The efficacy results are divided into two levels, A and B. Products that do not meet the B level standard are unqualified products.

[0144] Grade A: effective protection time ≥ 6.0h, Grade B: effective protection time ≥ 4.0h. The results are shown in Table 2.

[0145] Table 2 Test results of the repellent activity of mosquito repellent emulsion against Aedes albopictus

[0146]

[0147] The results of the determination of the repellent activity of the mosquito repellent emulsions on Aedes albopictus in Table 2 show that the effective repellent time of the mosquito repellent emulsions prepared in the preparation examples of the present invention on Aedes albopictus is greater than 6 hours, which is Class A. This is consistent with the results of Test Example 1. It can be seen that the effective protection time of the mosquito repellent emulsions prepared in the preparation examples of the present invention is significantly longer than that of the commercially available mosquito repellent emulsions with the same content of active ingredients. In particular, the mosquito repellent emulsion prepared in Preparation Example 3 is significantly longer than the commercially available mosquito repellent emulsions when the type and content of the mosquito repellent active substance are the same.

[0148] In summary, it can be seen that the mosquito repellent emulsion of the present invention has a sustained-release effect and can repel mosquitoes for a long time. In addition, the mosquito repellent emulsion of the present invention has excellent waterproof performance and better practicality.

[0149] The above contents are specific implementation methods with better effects of the present invention. The protection scope of the present invention should also cover the technical solutions and inventive concepts of the present invention.

Claims

1. A mosquito repellent emulsion, wherein the sum of the weight percentages is 100%, the mosquito repellent emulsion comprises the following components and their contents: The mosquito repellent active substance is selected from any one or more of DEET, immonin, icaridin, permethrin, eugenol, citronella oil, cinnamon oil, eucalyptus oil, camphor oil, lemon eucalyptus oil, peppermint oil, citronellol, citronellal, geraniol, linalool, citronellol alcohol, and cinnamaldehyde; The emulsifier is selected from any one or more of OP-9, OP-10, OP-50, cetyl phosphate, polyethylene glycol 400, Span-60, monoglyceride, and Tween-80; The moisturizer is selected from any one or more of glycerin, erythritol, sorbitol, xylitol, butylene glycol, (white) vaseline, white mineral oil, liquid paraffin, squalane, hyaluronic acid, and jojoba oil; The thickener is selected from: any one or more of carboxymethyl cellulose, cellulose ether, PEG-150 distearate, polyacrylamide, carbomer 934, carbomer 941, and carbomer 940; The sustained-release agent is selected from any one or more of xanthan gum, gelatin, gum arabic, chitosan, cross-linked polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyacrylic acid resin, acrylic acid resin, and polyacrylate; The waterproof material is selected from: any one or more of polyvinyl pyrrolidone, polyvinyl alcohol, hydroxyethyl cellulose, and methyl cellulose; The preservative is selected from any one or more of methylisothiazolinone, paraben, methylparaben, benzyl alcohol, sorbic acid, caprylhydroxamic acid, benzoic acid, sodium benzoate, sodium chloride, and disodium EDTA.

2. The mosquito repellent emulsion according to claim 1, wherein The mosquito repellent emulsion comprises the following components and their contents:

3. The mosquito repellent emulsion according to claim 1 or 2, wherein: The mosquito repellent active substance is selected from any one or more of DEET, immonin, icaridin, eugenol, citronella oil, eucalyptus oil, lemon eucalyptus oil, peppermint oil, citronellol, citronellol alcohol, and cinnamaldehyde; The emulsifier is selected from any one or more of cetyl phosphate, polyethylene glycol 400, Span-60, monoglyceride, and Tween-80; The moisturizer is selected from any one or more of glycerin, (white) vaseline, liquid paraffin, squalane, and hyaluronic acid; The thickener is selected from: any one or more of Carbomer 934, Carbomer 941, and Carbomer 940; The sustained-release agent is selected from any one or more of xanthan gum, gelatin, gum arabic, and acrylic resin; The waterproof material is selected from: any one or more of polyvinyl pyrrolidone, polyvinyl alcohol, and methyl cellulose; The preservative is selected from any one or more of benzyl alcohol, sorbic acid, benzoic acid, sodium benzoate, sodium chloride, and disodium EDTA.

4. The mosquito repellent emulsion according to any one of claims 1 to 3, wherein The mosquito repellent emulsion comprises the following components and their contents:

5. The mosquito repellent emulsion according to any one of claims 1 to 4, wherein The mosquito repellent active substance is selected from any one or more of DEET, imipenem, icaridin, eugenol, citric acid, and geraniol; The emulsifier is selected from: any one or more of Span-60 and monoglyceride of fatty acid; The moisturizer is selected from: any one or more of glycerin and liquid paraffin; The thickener is selected from: any one or more of Carbomer 941 and Carbomer 940; The sustained-release agent is selected from: gelatin; The waterproof material is selected from: polyvinyl pyrrolidone; The preservative is selected from any one or more of sodium benzoate, disodium EDTA, and sodium chloride.

6. The mosquito repellent emulsion according to any one of claims 1 to 5, wherein The mosquito repellent emulsion comprises the following components and their contents:

7. The mosquito repellent emulsion according to any one of claims 1 to 6, wherein The mosquito repellent active substance is any one or more of DEET, Imonene, Icaridin, and Citrin; The emulsifiers are: Span-60 and monoglyceride of fatty acid; The oil phase moisturizer is glycerin; the water phase moisturizer is liquid paraffin; The thickener is: Carbomer 941; The sustained-release agent is: gelatin; The waterproof material is: polyvinyl pyrrolidone; The preservative is sodium benzoate.

8. The mosquito repellent emulsion according to any one of claims 1 to 7, wherein The mosquito repellent emulsion comprises the following components and their contents:

9. The mosquito repellent emulsion according to any one of claims 1 to 8, wherein The mosquito repellent emulsion has water-proof and / or seawater-proof properties; and / or The effective protection time of the mosquito repellent emulsion is greater than 6 hours, preferably greater than 6.5 hours, more preferably greater than 6.7 hours, more preferably greater than 7 hours, more preferably greater than 8 hours, and more preferably greater than 8.5 hours.

10. A method for preparing the mosquito repellent emulsion according to any one of claims 1 to 9, comprising the following steps: (1) Stirring the sustained-release agent and the thickener in appropriate amounts of water to form a clear uniform solution of the sustained-release agent and the thickener; (2) dissolving the waterproof material in an appropriate amount of water and stirring evenly, adding a moisturizer (aqueous phase), and then adding a preheated uniform solution of a sustained-release agent and a uniform solution of a thickener, stirring evenly at an appropriate temperature to obtain a mixture A; (3) heating the emulsifier and moisturizer (oil phase) until they become liquid, adding them to the mixture A, and stirring them evenly to obtain a mixture B; (4) adding the preservative and the mosquito repellent active substance to the mixture B at a suitable temperature, adding water to the full amount, and stirring evenly to obtain the long-lasting waterproof mosquito repellent emulsion; Preferably, in step (2), the preheating temperature is 65-90°C, the stirring speed is 200-600 r / min, and the stirring time is 20-40 min; in step (3), the heating temperature is 65-85°C, the stirring speed is 800-1500 r / min, and the stirring time is 10-30 min; in step (4), the suitable temperature is 45-55°C, the stirring speed is 2000-3000 r / min, and the stirring time is 20-40 min; More preferably, in step (2), the preheating temperature is 70-80°C, the stirring speed is 300-500 r / min, and the stirring time is 25-35 min; in step (3), the heating temperature is 75-80°C, the stirring speed is 1000-1500 r / min, and the stirring time is 15-25 min; in step (4), the appropriate temperature is 45-50°C, the stirring speed is 2200-2800 r / min, and the stirring time is 15-30 min; Further preferably, in step (2), the preheating temperature is 70°C, the stirring speed is 300-400 r / min, and the stirring time is 30 min; in step (3), the heating temperature is 80°C, the stirring speed is 1100-1300 r / min, and the stirring time is 20 min; in step (4), the suitable temperature is 45°C, the stirring speed is 2400-2500 r / min, and the stirring time is 30 min.

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