Production device and production method of Wuzi Yanzong oral liquid preparation

Abstract

The invention discloses a production device and a production method of a Wuzi Yanzong oral liquid preparation, and relates to the technical field of oral liquid preparation.The production device comprises a uniform mixing tank, a cleaning liquid storage tank is fixedly arranged at the bottom of the uniform mixing tank, and a driving transmission mechanism is jointly arranged in the uniform mixing tank and the cleaning liquid storage tank; a suction mechanism, a filtering and discharging mechanism, a bouncing type uniform mixing mechanism and blocking mechanisms are sequentially arranged on the outer side of the driving and conveying mechanism from top to bottom, and the blocking mechanisms are located in the uniform mixing tank and the cleaning liquid storage tank respectively. According to the device, primary microspheres can be directly filtered out after being generated, so that the primary microsphere generation process and the primary microsphere filtering process are synchronously carried out, the primary microspheres can be automatically cleaned after being completely filtered out, the primary microsphere preparation efficiency is effectively improved, in addition, a mixed solution does not need to be cleaned, and the production cost is reduced. Therefore, the dosage of the cleaning liquid is less, and the preparation cost of the primary microspheres is effectively reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of oral liquid preparation, and in particular to a production device and a production method for a Wuzi Yanzong oral liquid preparation. Background Art

[0002] Wu Zi Yan Zong oral liquid can nourish the kidney and replenish essence, and is mainly used to treat symptoms such as low back pain, weak legs, spermatorrhea, premature ejaculation, impotence and infertility. However, since it contains some high-molecular impurities such as starch, protein, gum, mucus, polysaccharides, tannins and pigments, etc., there will be a certain amount of precipitation in the cooled Wu Zi Yan Zong oral liquid preparation.

[0003] The invention patent with authorization announcement number CN 116270850 B discloses a Wuzi Yanzong oral liquid and a preparation method thereof, comprising the following raw materials in parts by weight: 200-400 parts of wolfberry; 200-400 parts of dodder seed (fried); 100-200 parts of raspberry; 30-40 parts of schisandra (steamed with vinegar); 50-90 parts of plantain (fried with salt); the above five flavors are extracted twice with ethanol reflux, each time for 1-3 hours, the extracts are combined, filtered, ethanol is recovered from the filtrate until there is no alcohol taste, concentrated, centrifuged and filtered, sucrose and potassium sorbate are added to the filtrate, stirred to obtain a mixed solution, and then adsorption microspheres are added to the mixed solution, filtered, the total amount is adjusted, stirred, filled, and sterilized to obtain the product.

[0004] After the extraction of various Chinese medicinal raw materials, there may be many tannins in the extract, which are characterized by many phenolic hydroxyl groups and are easy to polymerize with each other, causing the molecules to increase, slowly clump and precipitate. Therefore, this invention adds adsorption microspheres of gelatin and xanthan gum to flocculate and adsorb them, thereby reducing the impact of this substance on the clarity of the oral solution.

[0005] However, after actual application by technicians skilled in the art, it was found that the above preparation method still has some shortcomings. The most obvious one is that in the preparation process of primary microspheres, technicians need to add a solution containing gelatin and xanthan gum to a mixture of paraffin oil and edible oil and mix them evenly, and then wash and filter the mixed solution to obtain primary microspheres. In this process, the forming process and separation process of the primary microspheres occur successively rather than simultaneously, which results in a long time to complete the separation of the primary microspheres after the primary microspheres are formed, which has a great impact on the preparation efficiency of the primary microspheres. In addition, since the mixed solution is directly washed, the required amount of washing liquid is large, which has a great impact on the preparation cost of the primary microspheres.

[0006] Therefore, it is necessary to invent a production device and a production method for Wu Zi Yan Zong oral liquid preparation to solve the above problems. Summary of the invention

[0007] The object of the present invention is to provide a production device and a production method for Wu Zi Yan Zong oral liquid preparation, which are provided with a driving transmission mechanism, a suction mechanism, a filtering and discharging mechanism, a bouncing mixing mechanism and a blocking mechanism, so that when the driving transmission mechanism drives the bouncing mixing mechanism to mix the mixed solution at different heights, the driving transmission mechanism synchronously drives the suction mechanism, so that the suction mechanism sucks the mixed solution at the bottom of the inner cavity of the mixing tank through the driving transmission mechanism and transports it to the top of the filtering and discharging mechanism, and the filtering and discharging mechanism filters out the formed primary microspheres in the mixed solution until all the primary microspheres are filtered out, and then, driven by the driving transmission mechanism, the blocking mechanism triggers the driving transmission mechanism, so that the suction mechanism sucks the cleaning solution through the driving transmission mechanism. The cleaning liquid inside the storage tank is sucked out and transported to the top of the filtering and discharging mechanism to complete the cleaning of the primary microspheres, so as to solve the problem that in the preparation process of the primary microspheres proposed in the above background technology, technicians need to add a solution containing gelatin and xanthan gum to a mixture of paraffin oil and edible oil and mix them evenly, and then clean and filter the mixed solution to obtain primary microspheres. In this process, the forming process and the separation process of the primary microspheres occur successively rather than simultaneously, which results in that it takes a long time to complete the separation of the primary microspheres after the primary microspheres are formed, which has a great impact on the preparation efficiency of the primary microspheres. In addition, since the mixed solution is directly cleaned, the amount of cleaning liquid required is large, which has a great impact on the preparation cost of the primary microspheres.

[0008] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a production device for Wuzi Yanzong oral liquid preparation, comprising a mixing tank, a cleaning liquid storage tank is fixedly arranged at the bottom of the mixing tank, a driving transmission mechanism is arranged inside the mixing tank and the cleaning liquid storage tank, a suction mechanism, a filtering and discharging mechanism, a bouncing mixing mechanism and a blocking mechanism are arranged on the outside of the driving transmission mechanism from top to bottom, and the blocking mechanisms are respectively located inside the mixing tank and the cleaning liquid storage tank; In the process of the driving transmission mechanism driving the bouncing mixing mechanism to mix the mixed solution, the driving transmission mechanism drives the suction mechanism, so that the suction mechanism sucks the mixed solution at the bottom of the inner cavity of the mixing tank through the driving transmission mechanism and transports it to the top of the filtering and discharging mechanism, and the filtering and discharging mechanism filters out the formed primary microspheres in the mixed solution until all the primary microspheres are filtered out. Then, driven by the driving transmission mechanism, the blocking mechanism triggers the driving transmission mechanism, so that the suction mechanism sucks the cleaning liquid inside the cleaning liquid storage tank through the driving transmission mechanism and transports the cleaning liquid to the top of the filtering and discharging mechanism, so as to complete the cleaning of the primary microspheres.

[0009] Preferably, the drive transmission mechanism includes a drive shaft and a drive motor; The driving shaft passes through the mixing tank and the cleaning liquid storage tank and is rotatably connected to the mixing tank and the cleaning liquid storage tank through bearings. The outer top and outer bottom of the driving shaft are respectively provided with a first reciprocating thread and a second reciprocating thread. The driving motor is fixedly arranged on the top of the mixing tank and is transmission-connected to the driving shaft.

[0010] Preferably, the drive transmission mechanism further includes a transmission channel, a mounting groove, a liquid outlet, a first liquid inlet and a second liquid inlet; The transmission channel is opened inside the driving shaft, the mounting groove is opened at the top of the side of the driving shaft, the liquid outlet, the first liquid inlet and the second liquid inlet are opened on the side of the driving shaft from top to bottom, and the liquid outlet, the first liquid inlet and the second liquid inlet are all connected to the transmission channel.

[0011] Preferably, the suction mechanism comprises a piston cylinder, a piston plate, a first guide rod, an output tube and a valve; The piston cylinder is rotatably sleeved on the outside of the driving shaft through a bearing and fixedly arranged on the top of the inner cavity of the mixing tank. A pressure relief hole is arranged on the top of the back side of the piston cylinder. The piston plate is sleeved on the outside of the driving shaft and is transmission-connected to the driving shaft through a first reciprocating thread. The piston plate is slidably arranged inside the piston cylinder along a vertical direction. The first guide rod slides through the mixing tank and the piston cylinder and is fixedly connected to the piston plate. The output pipe is fixedly penetrated on the bottom side of the piston cylinder, and the valve is fixedly connected to the bottom end of the output pipe.

[0012] Preferably, the filtering and discharging mechanism comprises a filter screen, a first mounting sleeve and a push plate; The filter is rotatably sleeved on the outside of the drive shaft through a bearing and fixedly connected to the inner wall of the mixing tank. The first mounting sleeve is fixedly sleeved on the outside of the drive shaft. The push plate is fixedly mounted on the outside of the first mounting sleeve and located on the top of the filter.

[0013] Preferably, the bouncing mixing mechanism comprises a fixing ring, a first semicircular projection, a return spring, a second mounting sleeve, a stirring shaft, a column and a second semicircular projection; The fixing ring is fixedly arranged at the bottom of the filter screen, a plurality of the first semicircular protrusions are arranged, and the plurality of the first semicircular protrusions are evenly fixedly arranged at the bottom of the fixing ring, the reset spring is sleeved on the outside of the driving shaft, the second mounting sleeve is slidably nested on the outside of the driving shaft along the vertical direction, the second mounting sleeve is rotatably connected to the bottom of the reset spring through a bearing, the inner side of the second mounting sleeve is fixedly arranged on the slider, a longitudinal groove is provided on the outer side of the driving shaft, the slider is slidably arranged on the inner side of the longitudinal groove along the vertical direction, the stirring shaft is fixedly arranged on the outer side of the second mounting sleeve, the column is fixedly arranged on the top of the stirring shaft, and the second semicircular protrusion is fixedly arranged on the top of the column.

[0014] Preferably, the blocking mechanism comprises a T-shaped shaft, a magnet, a connecting plate and a first blocking tube; The T-shaped shaft slides through the inner wall of the mounting groove and extends to the inside of the transmission channel. Two magnets are provided, one of which is fixed at the top of the T-shaped shaft, and the other is fixed at the top of the inner side of the mounting groove. The connecting plate is fixed at the bottom of the side of the T-shaped shaft and is slidably provided on the inner side of the liquid outlet in the vertical direction. The first blocking tube is slidably sleeved on the outer side of the driving shaft in the vertical direction and is fixedly connected to the connecting plate.

[0015] Preferably, the blocking mechanism further includes an annular gasket, a second blocking tube, a positioning plate and a second guide rod; The annular gasket is sleeved on the outside of the driving shaft and fixedly arranged on the bottom of the inner cavity of the mixing tank. The second sealing tube is sleeved on the bottom of the outside of the driving shaft and is transmission-connected to the driving shaft through a second reciprocating thread. The second sealing tube seals the second liquid inlet and its top end is slidably arranged on the inside of the annular gasket. The positioning plate is fixedly sleeved on the bottom of the outside of the second sealing tube. The second guide rod slides through the bottom of the cleaning liquid storage tank and is fixedly connected to the positioning plate.

[0016] The present invention also discloses a method for producing a Wuzi Yanzong oral liquid preparation, which is implemented using the above-mentioned production device for the Wuzi Yanzong oral liquid preparation. The method specifically comprises the following steps: S1, adding paraffin oil, edible oil and a solution containing gelatin and xanthan gum into the mixing tank in sequence to form a mixed solution, starting the driving motor, and driving the driving shaft to rotate after the driving motor is started. When the driving shaft rotates, the slider and the longitudinal slide groove drive the second installation sleeve to rotate synchronously. When the second installation sleeve rotates, it drives the stirring shaft to stir the mixed solution, thereby continuously generating primary microspheres; S2, during the rotation of the second installation sleeve, the second semicircular protrusion is driven by the column to rotate synchronously with the drive shaft as the axis. During this process, the second semicircular protrusion contacts and separates from the plurality of first semicircular protrusions in succession, and then during the repeated lifting and lowering process driven by the plurality of first semicircular protrusions, the stirring shaft and the second installation sleeve are driven to rise and fall synchronously by the column during the lifting and lowering process of the second semicircular protrusion, thereby completing the stirring of the mixed solution at different heights; S3, during the rotation of the driving shaft, the piston plate is driven to continuously rise inside the piston cylinder, and negative pressure is generated during the rising process of the piston cylinder. The negative pressure is transmitted to the first liquid inlet and the second liquid inlet through the liquid outlet and the transmission channel. Since the second liquid inlet is blocked by the second blocking tube, the mixed solution at the bottom of the inner cavity of the mixing tank enters the piston cylinder through the first liquid inlet, the transmission channel and the liquid outlet under the action of negative pressure; S4, when the piston plate rises to a first threshold, the top of the piston plate contacts the bottom of the T-shaped shaft. As the piston plate continues to rise, the T-shaped shaft drives the first blocking tube to rise synchronously on the outside of the drive shaft through the connecting plate. When the piston plate rises to a second threshold, the two magnets attract each other, and the first blocking tube blocks the liquid outlet. At this time, the piston plate moves to the top of the outside of the first reciprocating thread. As the drive shaft continues to rotate, the piston plate moves down and resets. S5, the mixed solution inside the piston cylinder is pressurized during the downward movement of the piston plate. As the piston plate continues to descend, the mixed solution inside the piston cylinder breaks the valve and falls on the top of the filter screen. The mixed solution passes through the filter screen and falls into the bottom of the inner cavity of the mixing tank to continue to react. The formed primary microspheres are blocked by the filter screen and retained on the top of the filter screen; S6, when the piston plate moves downwards to a third threshold, the bottom of the piston plate contacts the top of the first blocking tube, and as the piston plate continues to move downwards, the piston plate pushes the first blocking tube, thereby separating the two magnets from each other, and then under the action of gravity, the first blocking tube moves downwards and releases the blockage of the liquid outlet, and when the piston plate moves downwards to a fourth threshold, the piston plate moves to the initial position, i.e., the bottom end of the outer side of the first reciprocating thread, and as the drive shaft continues to rotate, the piston plate moves upwards again, thereby repeating the suction operation; S7, the driving shaft drives the piston plate to rise while driving the second plugging tube to rise. During the rising process, the second plugging tube pushes the mixed solution accumulated between the annular pad and the driving shaft. When the rising distance of the second plugging tube reaches the fifth threshold, the second plugging tube blocks the first liquid inlet and releases the blockage of the second liquid inlet. At this time, the mixed solution has reacted completely, and all the primary microspheres are accumulated on the top of the filter screen. S8. As the piston plate continues to rise, the piston plate sucks the cleaning liquid inside the cleaning liquid storage tank through the second liquid inlet, the transmission channel and the liquid outlet. When the piston plate descends, the cleaning liquid inside the piston cylinder is pushed, so that the primary microspheres on the top of the filter are cleaned. When the rising distance of the second plugging tube reaches the sixth threshold, the second plugging tube moves to the top of the outer side of the second reciprocating thread. As the drive shaft continues to rotate, the second plugging tube moves down and resets. S9, when the downward movement distance of the second plugging tube reaches the seventh threshold value, the second plugging tube releases the blockage of the first liquid inlet and blocks the second liquid inlet again. At this time, the primary microspheres are cleaned, and then the driving shaft drives the push plate through the first installation sleeve to push the primary microspheres, so that they are output through the pipeline on the side of the mixing tank. When the downward movement distance of the second plugging tube reaches the eighth threshold value, the second plugging tube arrives at the initial position, that is, the bottom end of the outer side of the second reciprocating thread. At this time, the output of the primary microspheres is completed, and then the driving motor is stopped; S10, placing the primary microspheres in a PBS solution containing EDC and NHS, placing in liquid nitrogen, performing freeze cross-linking at low temperature, thawing, washing with a dehydrating agent, precipitating, and freezing to obtain adsorption microspheres; S11. Add ethanol to a mixture of wolfberry, stir-fried dodder seeds, raspberries, vinegar-steamed schisandra chinensis and salt-fried plantain seeds, extract it twice by reflux, combine the extracts and filter, recover ethanol from the filtrate until there is no alcohol taste, then concentrate and centrifuge, add sucrose and potassium sorbate to the filtrate and stir to obtain a mixed solution, add adsorption microspheres to the mixed solution, adjust the total amount after filtering, and obtain the Wuzi Yanzong oral liquid preparation after stirring, filling and sterilization.

[0017] Technical effects and advantages of the present invention: The present invention is provided with a driving transmission mechanism, a suction mechanism, a filtering and discharging mechanism, a bouncing mixing mechanism and a blocking mechanism, so that when the driving transmission mechanism drives the bouncing mixing mechanism to mix the mixed solution at different heights, the driving transmission mechanism synchronously drives the suction mechanism, and then the suction mechanism sucks the mixed solution at the bottom of the inner cavity of the mixing tank through the driving transmission mechanism and transports it to the top of the filtering and discharging mechanism, and the filtering and discharging mechanism filters out the primary microspheres formed in the mixed solution until all the primary microspheres are filtered out, and then the blocking mechanism drives the driving transmission mechanism under the drive of the driving transmission mechanism. The structure is triggered, and then the suction mechanism drives the transmission mechanism to suck the cleaning liquid in the cleaning liquid storage tank and transports the cleaning liquid to the top of the filtering and discharging mechanism to complete the cleaning of the primary microspheres. Compared with the same type of device in the prior art, the present invention can directly filter out the primary microspheres after they are generated, so that the primary microsphere generation process and the primary microsphere filtration process are carried out simultaneously. After all the primary microspheres are filtered out, they can be automatically cleaned, which effectively improves the efficiency of preparing the primary microspheres. In addition, since there is no need to clean the mixed solution, the amount of cleaning liquid used is less, thereby effectively reducing the preparation cost of the primary microspheres. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0019] Figure 2 It is a schematic diagram of the structures of the driving transmission mechanism, the suction mechanism, the filtering and discharging mechanism, the bouncing mixing mechanism and the blocking mechanism of the present invention.

[0020] Figure 3 It is a schematic diagram of the structure of the driving transmission mechanism and the blocking mechanism of the present invention.

[0021] Figure 4 It is a schematic diagram of the structure of the suction mechanism and the filtering and discharging mechanism of the present invention.

[0022] Figure 5 It is a schematic diagram of the structure of the bouncing mixing mechanism of the present invention.

[0023] In the figure: 1, mixing tank; 2, cleaning liquid storage tank; 3, drive transmission mechanism; 31, drive shaft; 32, drive motor; 33, transmission channel; 34, mounting groove; 35, liquid outlet; 36, first liquid inlet; 37, second liquid inlet; 4, suction mechanism; 41, piston cylinder; 42, piston plate; 43, first guide rod; 44, output pipe; 45, valve; 5, filter discharging mechanism; 51, filter screen; 52, first installation Sleeve; 53, push plate; 6, bouncing mixing mechanism; 61, fixing ring; 62, first semicircular protrusion; 63, return spring; 64, second mounting sleeve; 65, stirring shaft; 66, column; 67, second semicircular protrusion; 7, blocking mechanism; 71, T-shaped shaft; 72, magnet; 73, connecting plate; 74, first blocking tube; 75, annular gasket; 76, second blocking tube; 77, positioning plate; 78, second guide rod. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example 1

[0026] The present invention provides Figure 1-5 The production device of a Wuzi Yanzong oral liquid preparation shown in the figure comprises a mixing tank 1, a cleaning liquid storage tank 2 is fixedly arranged at the bottom of the mixing tank 1, a driving transmission mechanism 3 is arranged inside the mixing tank 1 and the cleaning liquid storage tank 2, a suction mechanism 4, a filtering and discharging mechanism 5, a bouncing mixing mechanism 6 and a blocking mechanism 7 are arranged on the outside of the driving transmission mechanism 3 in order from top to bottom, and the blocking mechanism 7 is respectively located inside the mixing tank 1 and the cleaning liquid storage tank 2; In the process of the driving transmission mechanism 3 driving the bouncing mixing mechanism 6 to mix the mixed solution, the driving transmission mechanism 3 drives the suction mechanism 4, so that the suction mechanism 4 sucks the mixed solution at the bottom of the inner cavity of the mixing tank 1 through the driving transmission mechanism 3 and transports it to the top of the filtering and discharging mechanism 5, and the filtering and discharging mechanism 5 filters out the formed primary microspheres in the mixed solution until all the primary microspheres are filtered out. Then, driven by the driving transmission mechanism 3, the blocking mechanism 7 triggers the driving transmission mechanism 3, so that the suction mechanism 4 sucks the cleaning liquid inside the cleaning liquid storage tank 2 through the driving transmission mechanism 3 and transports the cleaning liquid to the top of the filtering and discharging mechanism 5, so as to complete the cleaning of the primary microspheres.

[0027] like Figure 3 As shown, the drive transmission mechanism 3 includes a drive shaft 31, a drive motor 32, a transmission channel 33, a mounting groove 34, a liquid outlet 35, a first liquid inlet 36 and a second liquid inlet 37, wherein the drive shaft 31 passes through the mixing tank 1 and the cleaning liquid storage tank 2 and is rotatably connected to the mixing tank 1 and the cleaning liquid storage tank 2 through bearings, and the outer top and outer bottom of the drive shaft 31 are respectively provided with a first reciprocating thread and a second reciprocating thread, the drive motor 32 is fixedly arranged on the top of the mixing tank 1 and is transmission-connected to the drive shaft 31, the transmission channel 33 is opened inside the drive shaft 31, the mounting groove 34 is opened on the top of the side of the drive shaft 31, the liquid outlet 35, the first liquid inlet 36 and the second liquid inlet 37 are sequentially opened on the side of the drive shaft 31 from top to bottom, and the liquid outlet 35, the first liquid inlet 36 and the second liquid inlet 37 are all connected to the transmission channel 33.

[0028] like Figure 4 As shown, the suction mechanism 4 includes a piston cylinder 41, a piston plate 42, a first guide rod 43, an output pipe 44 and a valve 45, wherein the piston cylinder 41 is rotatably sleeved on the outside of the drive shaft 31 through a bearing and fixedly arranged on the top of the inner cavity of the mixing tank 1, and a pressure relief hole is arranged on the top of the back side of the piston cylinder 41, the piston plate 42 is sleeved on the outside of the drive shaft 31 and is transmission connected to the drive shaft 31 through a first reciprocating thread, the piston plate 42 is slidably arranged inside the piston cylinder 41 along the vertical direction, the first guide rod 43 slides through the mixing tank 1 and the piston cylinder 41 and is fixedly connected to the piston plate 42, the output pipe 44 is fixedly penetrated and arranged on the bottom side of the piston cylinder 41, and the valve 45 is fixedly connected to the bottom end of the output pipe 44.

[0029] By setting the above-mentioned driving transmission mechanism 3 and suction mechanism 4, the driving motor 32 can drive the driving shaft 31 to rotate after being started. During the rotation of the driving shaft 31, the piston plate 42 is driven to continuously rise inside the piston cylinder 41. Negative pressure is generated during the rising process of the piston cylinder 41. The negative pressure is transmitted to the first liquid inlet 36 and the second liquid inlet 37 through the liquid outlet 35 and the transmission channel 33. Since the second liquid inlet 37 is blocked by the second blocking tube 76, the mixed solution at the bottom of the inner cavity of the mixing tank 1 enters the piston cylinder 41 through the first liquid inlet 36, the transmission channel 33 and the liquid outlet 35 under the action of negative pressure.

[0030] like Figure 4 As shown, the filtering and discharging mechanism 5 includes a filter screen 51, a first mounting sleeve 52 and a push plate 53, wherein the filter screen 51 is rotatably sleeved on the outside of the driving shaft 31 through a bearing and is fixedly connected to the inner wall of the mixing tank 1, the first mounting sleeve 52 is fixedly sleeved on the outside of the driving shaft 31, and the push plate 53 is fixedly disposed on the outside of the first mounting sleeve 52 and is located on the top of the filter screen 51.

[0031] By setting the above structure, when the mixed solution falls on the top of the filter 51, the mixed solution passes through the filter 51 and falls into the bottom of the inner cavity of the mixing tank 1 to continue reacting, and the formed primary microspheres are blocked by the filter 51 and retained on the top of the filter 51. After the subsequent cleaning of the primary microspheres is completed, the driving shaft 31 drives the pushing plate 53 through the first mounting sleeve 52 to push the primary microspheres, and then the primary microspheres are output through the pipe on the side of the mixing tank 1.

[0032] like Figure 5 As shown, the bouncing mixing mechanism 6 includes a fixing ring 61, a first semicircular protrusion 62, a return spring 63, a second mounting sleeve 64, a stirring shaft 65, a column 66 and a second semicircular protrusion 67, wherein the fixing ring 61 is fixedly arranged at the bottom of the filter screen 51, a plurality of first semicircular protrusions 62 are provided, and a plurality of first semicircular protrusions 62 are evenly fixedly arranged at the bottom of the fixing ring 61, the return spring 63 is sleeved on the outside of the driving shaft 31, the second mounting sleeve 64 is slidably nested on the outside of the driving shaft 31 in the vertical direction, the second mounting sleeve 64 is rotatably connected to the bottom of the return spring 63 through a bearing, the inner side of the second mounting sleeve 64 is fixedly arranged on the slider, a longitudinal slide groove is provided on the outer side of the driving shaft 31, the slider is slidably arranged on the inner side of the longitudinal slide groove in the vertical direction, the stirring shaft 65 is fixedly arranged on the outer side of the second mounting sleeve 64, the column 66 is fixedly arranged on the top of the stirring shaft 65, and the second semicircular protrusion 67 is fixedly arranged on the top of the column 66.

[0033] By setting the above structure, when the driving shaft 31 rotates, the second mounting sleeve 64 is driven to rotate synchronously through the slider and the longitudinal slide groove. When the second mounting sleeve 64 rotates, it drives the stirring shaft 65 to stir the mixed solution, thereby continuously generating primary microspheres. During the rotation of the second mounting sleeve 64, the second semicircular protrusion 67 is driven by the column 66 to rotate synchronously with the driving shaft 31 as the axis. During this process, the second semicircular protrusion 67 successively contacts and separates from multiple first semicircular protrusions 62, and then in the process of repeated lifting and lowering driven by multiple first semicircular protrusions 62, the second semicircular protrusion 67 is lifted and lowered by the column 66, thereby completing the stirring of the mixed solution at different heights.

[0034] like Figure 3As shown, the blocking mechanism 7 includes a T-shaped shaft 71, a magnet 72, a connecting plate 73, a first blocking tube 74, an annular gasket 75, a second blocking tube 76, a positioning plate 77 and a second guide rod 78, wherein the T-shaped shaft 71 slides through the inner wall of the mounting groove 34 and extends to the inside of the transmission channel 33, and two magnets 72 are provided, one of which is fixedly provided at the top of the T-shaped shaft 71, and the other is fixedly provided at the top of the inner side of the mounting groove 34, and the connecting plate 73 is fixedly provided at the bottom of the side of the T-shaped shaft 71 and is slidably provided at the inner side of the liquid outlet 35 in the vertical direction, and the first blocking tube 74 is provided. It is slidably sleeved along the vertical direction on the outside of the driving shaft 31 and fixedly connected to the connecting plate 73. The annular gasket 75 is sleeved on the outside of the driving shaft 31 and fixedly arranged at the bottom of the inner cavity of the mixing tank 1. The second sealing tube 76 is sleeved on the bottom of the outside of the driving shaft 31 and is transmission-connected to the driving shaft 31 through a second reciprocating thread. The second sealing tube 76 seals the second liquid inlet 37 and its top end is slidably arranged on the inside of the annular gasket 75. The positioning plate 77 is fixedly sleeved on the bottom of the outside of the second sealing tube 76. The second guide rod 78 slides through the bottom of the cleaning liquid storage tank 2 and is fixedly connected to the positioning plate 77.

[0035] By setting the above structure, after the top of the piston plate 42 contacts the bottom of the T-shaped shaft 71, as the piston plate 42 continues to rise, the T-shaped shaft 71 drives the first blocking tube 74 to rise synchronously on the outside of the driving shaft 31 through the connecting plate 73 until the two magnets 72 are attracted to each other, at which time the first blocking tube 74 blocks the liquid outlet 35; In the process of the driving shaft 31 driving the piston plate 42 to rise, the second sealing tube 76 is simultaneously driven to rise. In the process of the second sealing tube 76 rising, the mixed solution accumulated between the annular gasket 75 and the driving shaft 31 is pushed. As the second sealing tube 76 continues to rise, the second sealing tube 76 blocks the first liquid inlet 36 and releases the blockage of the second liquid inlet 37, so that the cleaning liquid storage tank 2 no longer sucks the mixed solution at the bottom of the inner cavity of the mixing tank 1, but starts to suck the cleaning liquid inside the cleaning liquid storage tank 2.

[0036] Example 2

[0037] The present invention also discloses a method for producing a Wuzi Yanzong oral liquid preparation, which is implemented using the above-mentioned production device for the Wuzi Yanzong oral liquid preparation. The method specifically comprises the following steps: S1, adding paraffin oil, edible oil and a solution containing gelatin and xanthan gum into the mixing tank 1 in sequence to form a mixed solution, starting the drive motor 32, and driving the drive shaft 31 to rotate after the drive motor 32 is started. When the drive shaft 31 rotates, it drives the second mounting sleeve 64 to rotate synchronously through the slider and the longitudinal slide groove. When the second mounting sleeve 64 rotates, it drives the stirring shaft 65 to stir the mixed solution, thereby continuously generating primary microspheres; S2, during the rotation of the second installation sleeve 64, the second semicircular protrusion 67 is driven by the column 66 to rotate synchronously with the drive shaft 31 as the axis. During this process, the second semicircular protrusion 67 successively contacts and separates from the plurality of first semicircular protrusions 62, and then during the repeated lifting process driven by the plurality of first semicircular protrusions 62, the second semicircular protrusion 67 is lifted and lowered, and the stirring shaft 65 and the second installation sleeve 64 are driven by the column 66 to lift and lower synchronously, thereby completing the stirring of the mixed solution at different heights; S3, during the rotation of the driving shaft 31, the piston plate 42 is driven to continuously rise inside the piston cylinder 41, and negative pressure is generated during the rising process of the piston cylinder 41. The negative pressure is transmitted to the first liquid inlet 36 and the second liquid inlet 37 through the liquid outlet 35 and the transmission channel 33. Since the second liquid inlet 37 is blocked by the second blocking tube 76, the mixed solution at the bottom of the inner cavity of the mixing tank 1 enters the piston cylinder 41 through the first liquid inlet 36, the transmission channel 33 and the liquid outlet 35 under the action of negative pressure; S4, when the rising distance of the piston plate 42 reaches the first threshold, the top of the piston plate 42 contacts the bottom of the T-shaped shaft 71, and as the piston plate 42 continues to rise, the T-shaped shaft 71 drives the first blocking tube 74 to rise synchronously on the outside of the drive shaft 31 through the connecting plate 73. When the rising distance of the piston plate 42 reaches the second threshold, the two magnets 72 are attracted to each other, and the first blocking tube 74 blocks the liquid outlet 35. At this time, the piston plate 42 moves to the top of the outside of the first reciprocating thread, and as the drive shaft 31 continues to rotate, the piston plate 42 moves down and resets. S5, during the downward movement of the piston plate 42, the mixed solution inside the piston cylinder 41 is pressurized. As the piston plate 42 continues to descend, the mixed solution inside the piston cylinder 41 breaks through the valve 45 and falls on the top of the filter 51. The mixed solution passes through the filter 51 and falls into the bottom of the inner cavity of the mixing tank 1 to continue reacting. The formed primary microspheres are blocked by the filter 51 and retained on the top of the filter 51. S6, when the piston plate 42 moves downward to a third threshold, the bottom of the piston plate 42 contacts the top of the first blocking tube 74, and as the piston plate 42 continues to move downward, the piston plate 42 pushes the first blocking tube 74, thereby separating the two magnets 72 from each other, and then under the action of gravity, the first blocking tube 74 moves downward and releases the blockage of the liquid outlet 35, and when the piston plate 42 moves downward to a fourth threshold, the piston plate 42 moves to the initial position, i.e., the bottom end of the outer side of the first reciprocating thread, and as the drive shaft 31 continues to rotate, the piston plate 42 moves upward again, thereby repeating the suction operation; S7, the driving shaft 31 drives the piston plate 42 to rise while driving the second blocking tube 76 to rise. During the rising process, the second blocking tube 76 pushes the mixed solution accumulated between the annular pad 75 and the driving shaft 31. When the rising distance of the second blocking tube 76 reaches the fifth threshold, the second blocking tube 76 blocks the first liquid inlet 36 and releases the blockage of the second liquid inlet 37. At this time, the mixed solution has reacted completely, and the primary microspheres are all accumulated on the top of the filter screen 51. S8. As the piston plate 42 continues to rise, the piston plate 42 sucks the cleaning liquid inside the cleaning liquid storage tank 2 through the second liquid inlet 37, the transmission channel 33 and the liquid outlet 35. When the piston plate 42 descends, the cleaning liquid inside the piston cylinder 41 is pushed, so that the primary microspheres on the top of the filter screen 51 are cleaned. When the rising distance of the second blocking tube 76 reaches the sixth threshold, the second blocking tube 76 moves to the top of the outer side of the second reciprocating thread. As the drive shaft 31 continues to rotate, the second blocking tube 76 moves down and resets. S9, when the downward movement distance of the second plugging tube 76 reaches the seventh threshold value, the second plugging tube 76 releases the blockage of the first liquid inlet 36, and blocks the second liquid inlet 37 again. At this time, the primary microspheres are cleaned, and then the driving shaft 31 drives the push plate 53 through the first installation sleeve 52 to push the primary microspheres, so that they are output through the pipeline on the side of the mixing tank 1. When the downward movement distance of the second plugging tube 76 reaches the eighth threshold value, the second plugging tube 76 arrives at the initial position, that is, the bottom end of the outer side of the second reciprocating thread. At this time, the output of the primary microspheres is completed, and then the driving motor 32 is stopped; S10, placing the primary microspheres in a PBS solution containing EDC and NHS, placing in liquid nitrogen, performing freeze cross-linking at low temperature, thawing, washing with a dehydrating agent, precipitating, and freezing to obtain adsorption microspheres; S11. Add ethanol to a mixture of wolfberry, stir-fried dodder seeds, raspberries, vinegar-steamed schisandra chinensis and salt-fried plantain seeds, extract it twice by reflux, combine the extracts and filter, recover ethanol from the filtrate until there is no alcohol taste, then concentrate and centrifuge, add sucrose and potassium sorbate to the filtrate and stir to obtain a mixed solution, add adsorption microspheres to the mixed solution, adjust the total amount after filtering, and obtain the Wuzi Yanzong oral liquid preparation after stirring, filling and sterilization.

[0038] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A production device for Wuzi Yanzong oral liquid preparation, characterized in that: The invention comprises a mixing tank (1), a cleaning liquid storage tank (2) being fixedly arranged at the bottom of the mixing tank (1), a driving transmission mechanism (3) being arranged inside the mixing tank (1) and the cleaning liquid storage tank (2), a suction mechanism (4), a filtering and discharging mechanism (5), a bouncing mixing mechanism (6) and a blocking mechanism (7) being arranged on the outside of the driving transmission mechanism (3) in order from top to bottom, and the blocking mechanism (7) being located inside the mixing tank (1) and the cleaning liquid storage tank (2) respectively; In the process of the driving transmission mechanism (3) driving the bouncing mixing mechanism (6) to mix the mixed solution, the driving transmission mechanism (3) drives the suction mechanism (4), thereby causing the suction mechanism (4) to suck the mixed solution at the bottom of the inner cavity of the mixing tank (1) through the driving transmission mechanism (3) and transport it to the top of the filtering and discharging mechanism (5), and the filtering and discharging mechanism (5) filters out the primary microspheres that have been formed in the mixed solution until all the primary microspheres are filtered out. Subsequently, driven by the driving transmission mechanism (3), the blocking mechanism (7) triggers the driving transmission mechanism (3), thereby causing the suction mechanism (4) to suck the cleaning liquid in the cleaning liquid storage tank (2) through the driving transmission mechanism (3) and transport the cleaning liquid to the top of the filtering and discharging mechanism (5), so as to complete the cleaning of the primary microspheres.

2. The production device of a Wuzi Yanzong oral liquid preparation according to claim 1, characterized in that: The drive transmission mechanism (3) comprises a drive shaft (31) and a drive motor (32); The drive shaft (31) passes through the mixing tank (1) and the cleaning liquid storage tank (2) and is rotatably connected to the mixing tank (1) and the cleaning liquid storage tank (2) via bearings; a first reciprocating thread and a second reciprocating thread are respectively provided at the outer top and the outer bottom of the drive shaft (31); the drive motor (32) is fixedly provided at the top of the mixing tank (1) and is drivingly connected to the drive shaft (31).

3. The production device of a Wuzi Yanzong oral liquid preparation according to claim 2, characterized in that: The drive transmission mechanism (3) further comprises a transmission channel (33), a mounting groove (34), a liquid outlet (35), a first liquid inlet (36) and a second liquid inlet (37); The transmission channel (33) is opened inside the driving shaft (31), the mounting groove (34) is opened at the top of the side of the driving shaft (31), the liquid outlet (35), the first liquid inlet (36) and the second liquid inlet (37) are opened in sequence from top to bottom on the side of the driving shaft (31), and the liquid outlet (35), the first liquid inlet (36) and the second liquid inlet (37) are all connected to the transmission channel (33).

4. The production device of the Wuzi Yanzong oral liquid preparation according to claim 3, characterized in that: The suction mechanism (4) comprises a piston cylinder (41), a piston plate (42), a first guide rod (43), an output tube (44) and a valve (45); The piston cylinder (41) is rotatably sleeved on the outside of the drive shaft (31) via a bearing and is fixedly arranged on the top of the inner cavity of the mixing tank (1). A pressure relief hole is arranged on the top of the back side of the piston cylinder (41). The piston plate (42) is sleeved on the outside of the drive shaft (31) and is transmission-connected to the drive shaft (31) via a first reciprocating thread. The piston plate (42) is slidably arranged inside the piston cylinder (41) along a vertical direction. The first guide rod (43) slides through the mixing tank (1) and the piston cylinder (41) and is fixedly connected to the piston plate (42). The output pipe (44) is fixedly penetrated on the bottom side of the piston cylinder (41). The valve (45) is fixedly connected to the bottom end of the output pipe (44).

5. The production device of the Wuzi Yanzong oral liquid preparation according to claim 4, characterized in that: The filtering and discharging mechanism (5) comprises a filter screen (51), a first mounting sleeve (52) and a pushing plate (53); The filter screen (51) is rotatably sleeved on the outside of the drive shaft (31) via a bearing and is fixedly connected to the inner wall of the mixing tank (1); the first mounting sleeve (52) is fixedly sleeved on the outside of the drive shaft (31); and the push plate (53) is fixedly disposed on the outside of the first mounting sleeve (52) and is located on the top of the filter screen (51).

6. The production device of the Wuzi Yanzong oral liquid preparation according to claim 5, characterized in that: The bouncing mixing mechanism (6) comprises a fixing ring (61), a first semicircular protrusion (62), a return spring (63), a second mounting sleeve (64), a stirring shaft (65), a column (66) and a second semicircular protrusion (67); The fixing ring (61) is fixedly arranged at the bottom of the filter screen (51); a plurality of first semicircular protrusions (62) are provided, and the plurality of first semicircular protrusions (62) are evenly fixedly arranged at the bottom of the fixing ring (61); the return spring (63) is sleeved and arranged on the outside of the drive shaft (31); the second mounting sleeve (64) is slidably nested and arranged on the outside of the drive shaft (31) in a vertical direction; the second mounting sleeve (64) is rotatably connected to the bottom end of the return spring (63) through a bearing; the inner side of the second mounting sleeve (64) is fixedly arranged on a slider; a longitudinal slide groove is provided on the outer side of the drive shaft (31); the slider is slidably arranged on the inner side of the longitudinal slide groove in a vertical direction; the stirring shaft (65) is fixedly arranged on the outer side of the second mounting sleeve (64); the column (66) is fixedly arranged on the top of the stirring shaft (65); and the second semicircular protrusion (67) is fixedly arranged on the top of the column (66).

7. The production device of the Wuzi Yanzong oral liquid preparation according to claim 6, characterized in that: The blocking mechanism (7) comprises a T-shaped shaft (71), a magnet (72), a connecting plate (73) and a first blocking tube (74); The T-shaped shaft (71) slides through the inner wall of the installation groove (34) and extends into the interior of the transmission channel (33); two magnets (72) are provided, one of the magnets (72) is fixedly provided at the top of the T-shaped shaft (71), and the other of the magnets (72) is fixedly provided at the top of the inner side of the installation groove (34); the connecting plate (73) is fixedly provided at the bottom of the side of the T-shaped shaft (71) and is slidably provided at the inner side of the liquid outlet (35) in the vertical direction; the first blocking tube (74) is slidably sleeved at the outer side of the driving shaft (31) in the vertical direction and is fixedly connected to the connecting plate (73).

8. The production device of the Wuzi Yanzong oral liquid preparation according to claim 7, characterized in that: The blocking mechanism (7) further comprises an annular gasket (75), a second blocking tube (76), a positioning plate (77) and a second guide rod (78); The annular gasket (75) is sleeved on the outside of the drive shaft (31) and fixedly arranged on the bottom of the inner cavity of the mixing tank (1); the second blocking tube (76) is sleeved on the bottom of the outside of the drive shaft (31) and is transmission-connected to the drive shaft (31) via a second reciprocating thread; the second blocking tube (76) blocks the second liquid inlet (37) and its top end is slidably arranged on the inside of the annular gasket (75); the positioning plate (77) is fixedly sleeved on the bottom of the outside of the second blocking tube (76); the second guide rod (78) slides through the bottom of the cleaning liquid storage tank (2) and is fixedly connected to the positioning plate (77).

9. A method for producing a Wuzi Yanzong oral liquid preparation, which is realized using the above-mentioned production device for the Wuzi Yanzong oral liquid preparation, characterized in that: The method specifically comprises the following steps: S1, adding paraffin oil, edible oil and a solution containing gelatin and xanthan gum into the mixing tank (1) in sequence to form a mixed solution, starting the driving motor (32), and after the driving motor (32) is started, driving the driving shaft (31) to rotate, and when the driving shaft (31) rotates, the second mounting sleeve (64) is driven to rotate synchronously through the slider and the longitudinal slide groove, and when the second mounting sleeve (64) rotates, it drives the stirring shaft (65) to stir the mixed solution, thereby continuously generating primary microspheres; S2, during the rotation of the second installation sleeve (64), the second semicircular protrusion (67) is driven by the column (66) to rotate synchronously with the drive shaft (31) as the axis. During this process, the second semicircular protrusion (67) successively contacts and separates from the plurality of first semicircular protrusions (62). Then, during the repeated lifting and lowering process driven by the plurality of first semicircular protrusions (62), the second semicircular protrusion (67) is driven by the column (66) to lift and lower the stirring shaft (65) and the second installation sleeve (64) synchronously, thereby completing the stirring of the mixed solution at different heights; S3, during the rotation of the driving shaft (31), the piston plate (42) is driven to continuously rise inside the piston cylinder (41), and negative pressure is generated during the rising process of the piston cylinder (41). The negative pressure is transmitted to the first liquid inlet (36) and the second liquid inlet (37) through the liquid outlet (35) and the transmission channel (33). Since the second liquid inlet (37) is blocked by the second blocking tube (76), the mixed solution at the bottom of the inner cavity of the mixing tank (1) enters the interior of the piston cylinder (41) through the first liquid inlet (36), the transmission channel (33) and the liquid outlet (35) under the action of negative pressure; S4, when the rising distance of the piston plate (42) reaches a first threshold value, the top of the piston plate (42) contacts the bottom of the T-shaped shaft (71), and as the piston plate (42) continues to rise, the T-shaped shaft (71) drives the first blocking tube (74) to rise synchronously on the outside of the drive shaft (31) through the connecting plate (73). When the rising distance of the piston plate (42) reaches a second threshold value, the two magnets (72) attract each other, and at the same time, the first blocking tube (74) blocks the liquid outlet (35). At this time, the piston plate (42) moves to the top of the outside of the first reciprocating thread, and as the drive shaft (31) continues to rotate, the piston plate (42) moves downward and resets; S5, during the downward movement of the piston plate (42), the mixed solution inside the piston cylinder (41) is pressurized. As the piston plate (42) continues to descend, the mixed solution inside the piston cylinder (41) breaks through the valve (45) and falls on the top of the filter screen (51). The mixed solution passes through the filter screen (51) and falls into the bottom of the inner cavity of the mixing tank (1) to continue to react. The formed primary microspheres are blocked by the filter screen (51) and retained on the top of the filter screen (51); S6, when the piston plate (42) moves downward a distance that reaches a third threshold, the bottom of the piston plate (42) contacts the top of the first blocking tube (74), and as the piston plate (42) continues to move downward, the piston plate (42) pushes the first blocking tube (74), thereby separating the two magnets (72) from each other, and then under the action of gravity, the first blocking tube (74) moves downward and releases the blockage of the liquid outlet (35). When the piston plate (42) moves downward a distance that reaches a fourth threshold, the piston plate (42) moves to the initial position, i.e., the bottommost end of the outer side of the first reciprocating thread, and as the drive shaft (31) continues to rotate, the piston plate (42) moves upward again, thereby repeating the suction operation; S7, the driving shaft (31) drives the piston plate (42) to rise while simultaneously driving the second blocking tube (76) to rise. During the rising process, the second blocking tube (76) pushes the mixed solution accumulated between the annular gasket (75) and the driving shaft (31). When the rising distance of the second blocking tube (76) reaches a fifth threshold, the second blocking tube (76) blocks the first liquid inlet (36) and releases the blockage of the second liquid inlet (37). At this time, the mixed solution has reacted completely and all the primary microspheres are accumulated on the top of the filter screen (51); S8. As the piston plate (42) continues to rise, the piston plate (42) sucks the cleaning liquid in the cleaning liquid storage tank (2) through the second liquid inlet (37), the transmission channel (33) and the liquid outlet (35). When the piston plate (42) subsequently descends, the cleaning liquid in the piston cylinder (41) is pushed, thereby cleaning the primary microspheres on the top of the filter screen (51). When the rising distance of the second blocking tube (76) reaches the sixth threshold, the second blocking tube (76) moves to the top of the outer side of the second reciprocating thread. Subsequently, as the drive shaft (31) continues to rotate, the second blocking tube (76) moves downward and resets. S9, when the downward movement distance of the second plugging tube (76) reaches the seventh threshold value, the second plugging tube (76) releases the blockage of the first liquid inlet (36) and blocks the second liquid inlet (37) again. At this time, the cleaning of the primary microspheres is completed. Then, the driving shaft (31) drives the push plate (53) through the first installation sleeve (52) to push the primary microspheres, thereby causing them to be output through the pipeline on the side of the mixing tank (1). When the downward movement distance of the second plugging tube (76) reaches the eighth threshold value, the second plugging tube (76) arrives at the initial position, that is, the bottom end of the outer side of the second reciprocating thread. At this time, the output of the primary microspheres is completed, and then the driving motor (32) is stopped; S10, placing the primary microspheres in a PBS solution containing EDC and NHS, placing in liquid nitrogen, performing freeze cross-linking at low temperature, thawing, washing with a dehydrating agent, precipitating, and freezing to obtain adsorption microspheres; S11. Add ethanol to a mixture of wolfberry, stir-fried dodder seeds, raspberries, vinegar-steamed schisandra chinensis and salt-fried plantain seeds, extract it twice by reflux, combine the extracts and filter, recover ethanol from the filtrate until there is no alcohol taste, then concentrate and centrifuge, add sucrose and potassium sorbate to the filtrate and stir to obtain a mixed solution, add adsorption microspheres to the mixed solution, adjust the total amount after filtering, and obtain the Wuzi Yanzong oral liquid preparation after stirring, filling and sterilization.

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