Auxiliary injection platform for endothelial reaction test

Abstract

The invention relates to an auxiliary injection platform for an endothelial reaction test, and the auxiliary injection platform comprises a base assembly which comprises a base and an X-direction slide rail arranged on the upper side of the base; the X-direction sliding block is in sliding connection with the X-direction sliding rail; the Y-direction sliding rail assembly comprises a Y-direction supporting frame, the Y-direction supporting frame is fixedly connected with the base, and a Y-direction sliding rail is arranged on the Y-direction supporting frame; the Z-direction sliding rail assembly comprises a Y-direction sliding block and a Z-direction sliding rail arranged on the rear end face of the Y-direction sliding block, and the Y-direction sliding block is in sliding connection with the Y-direction sliding rail; the Z-direction sliding block is in sliding connection with the Z-direction sliding rail; the injector assembly is fixedly connected to the Z-direction sliding block; the driving assembly can drive the X-direction sliding block, the Y-direction sliding block and the Z-direction sliding block to move in the X direction, the Y direction and the Z direction respectively. According to the auxiliary injection device, the continuous and multi-point endothelial injection process of an experimental animal can be fully automatically completed in the endothelial test process, and the labor intensity of operators is reduced.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to an auxiliary injection platform for endothelial reaction. Background Art

[0002] Interventional medical devices, such as vascular stents, occluders or filters, may contain a variety of chemical components after the production process, such as dyes, adhesives, and sterilizer residues produced during the sterilization process. It should be considered whether these components have potential irritation activity. The characteristics of irritation may be inflammation, redness, swelling, fever and pain. Therefore, irritation testing is crucial to evaluate the potential of interventional medical devices to cause irritation reactions after exposure to the human body.

[0003] In order to evaluate the irritation reaction of interventional medical devices to the human body, an irritation test is required. The endothelial reaction test is a conventional irritation test method, which evaluates the possibility of causing irritation by injecting the extract of the medical device into the skin. During the test, multiple injections are required at specific parts of the test animals, such as multiple injections of extract at equal intervals along the longitudinal direction (head to tail) on the left side of the rabbit spine, and multiple injections of control solution at equal intervals along the longitudinal direction on the right side of the rabbit spine, and each injection point on the left side is required to be aligned with the injection point on the right side. Therefore, the endothelial reaction test requires multiple injections of the test animals, and the position of the injection points is required to be high. At present, manual injection is usually used, which has high requirements for operators and high labor intensity. Summary of the invention

[0004] Based on this, in order to solve the above problems, the present invention provides an auxiliary injection platform for endothelial reaction test, which can complete fully automated injection to replace the manual injection process. The auxiliary injection device includes: a base assembly, including a base and an X-axis slide rail arranged on the upper side of the base; an X-axis slider, which is slidably connected to the X-axis slide rail; a Y-axis slide rail assembly, including a Y-axis support frame, the Y-axis support frame is fixedly connected to the base, and a Y-axis slide rail is arranged on the Y-axis support frame; a Z-axis slide rail assembly, including a Y-axis slider and a Z-axis slide rail arranged on the rear end surface of the Y-axis slider, the Y-axis slider is slidably connected to the Y-axis slide rail; a Z-axis slider is slidably connected to the Z-axis slide rail; a syringe assembly, fixedly connected to the Z-axis slider; a drive assembly, which can drive the X-axis slider, the Y-axis slider and the Z-axis slider to move in the X-axis, Y-axis and Z-axis directions respectively.

[0005] Furthermore, it also includes an injection pre-compression piece, the syringe assembly includes an injection needle, the injection pre-compression piece includes a retractable connecting rod assembly and a pre-compression ring, one end of the connecting rod assembly is fixedly connected to the Z-axis slider, and the other end is fixedly connected to the pre-compression ring, and the injection needle can pass through the pre-compression ring.

[0006] Furthermore, the longitudinal axis of the injection needle is substantially parallel to or coincides with the central axis of the pre-compression ring.

[0007] Furthermore, a pressure sensor is provided on the lower end surface of the pre-compression ring.

[0008] Furthermore, a disinfecting element is provided on the lower end surface of the pre-compression ring.

[0009] Furthermore, the connecting rod assembly includes a first connecting rod, a second connecting rod, and a third connecting rod connected in sequence, the free end of the first connecting rod is fixedly connected to the X-axis slider, and the third connecting rod is fixedly connected to the pre-compression ring b.

[0010] Furthermore, the second connecting rod includes a first rod unit and a second rod unit that are slidably connected to each other, and an elastic member is further provided between opposite end surfaces of the first rod unit and the second rod unit.

[0011] Furthermore, it includes a first reinforcing rod and a second reinforcing rod, wherein one end of the first reinforcing rod is connected to the first connecting rod and the other end is connected to the first rod unit, and one end of the second reinforcing rod is connected to the third connecting rod and the other end is connected to the second rod unit.

[0012] Furthermore, a longitudinal axis of the second connecting rod is substantially parallel to a central axis of the pre-compression ring.

[0013] Furthermore, a camera is also provided on the injection pre-press.

[0014] The technical solution of the present invention has the following beneficial effects:

[0015] 1. The injection needle of the present invention has three degrees of freedom of X, Y, and Z relative to the X-direction slider on which the test animal is placed, thereby realizing fully automated operation of multi-point injection of the injection needle on the test animal, reducing the requirements for the test operator, reducing the workload of the test operator, and improving the success rate of multiple injections. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is the overall three-dimensional structural diagram of the auxiliary injection device;

[0017] Figure 2 A three-dimensional structural diagram of the auxiliary injection device without the base, etc.;

[0018] Figure 3 is a first partial stereoscopic view of the auxiliary injection device;

[0019] Figure 4 is a second partial stereoscopic view of the auxiliary injection device;

[0020] Figure 5for Figure 1 A in the enlarged view;

[0021] Figure 6 is a partial cross-sectional view of the second connecting rod;

[0022] Figure 7 It is a partial exploded view of the auxiliary injection device; DETAILED DESCRIPTION

[0023] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific implementation disclosed below.

[0024] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be an element centered thereon. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an element centered thereon. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method. The up, down, left and right directions of the present invention are described in detail in the following manner: Figure 1 The X direction (i.e., along the X-axis direction), the Y direction (i.e., along the Y-axis direction), and the Z direction (i.e., along the Z-axis direction) of the present invention are based on Figure 1 The markings in are used as reference.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0026] First embodiment

[0027] See also Figure 1As shown, this embodiment provides an auxiliary injection device 100 for endothelial reaction test, which is used for performing endothelial injection on test animals such as rabbits, mice, etc. in animal tests to perform endothelial reaction tests. Specifically, the device 100 includes a base assembly 10, which includes a base 11 and an X-axis slide rail 13 arranged on the base; a platform assembly 20, which includes an X-axis slider 21, which is slidably arranged on the X-axis slide rail 13; a Y-axis slide rail assembly 30, including a Y-axis support frame 34, the Y-axis support frame 34 is fixed on the base 11, and a Y-axis slide rail 32 is arranged in the Y-axis support frame 34; a Z-axis slide rail assembly 40, including a Y-axis slider 42, the front side surface of the Y-axis slider 42 is slidably connected to the Y-axis slide rail 32, and the rear side surface is provided with a Z-axis slide rail 45; a Z-axis slider assembly 50, which is slidably connected to the Z-axis slide rail 45; and a syringe assembly 60, which is fixedly connected to the Z-axis slider assembly 50. In addition, the auxiliary injection device 100 also has a driving component, which includes an X-axis driving unit XM, a Y-axis driving unit YM, and a Z-axis driving unit ZM, which can drive the X-axis slider 21, the Y-axis slider 42, and the Z-axis slider 51 to move along the X-axis, the Y-axis, and the Z-axis directions respectively.

[0028] Continue to see Figure 1As shown, the base assembly 10 includes a base 11, which is a square frame structure, and legs 12 are respectively arranged near the four corners of the lower end surface. Optionally, the legs 12 are retractable legs, and elastic damping members are arranged on the lower end surface. By setting the legs 12 in a retractable form, the horizontality of the base 11 can be adjusted by adjusting the heights of different legs 12. By setting the elastic damping members, vibration reduction and buffering of the entire auxiliary injection device can be achieved. X-direction slide rails 13 are fixedly arranged on the left and right sides above the base 11, and the X-direction slide rails 13 extend along the X-direction. In addition, an X-direction drive unit XM is also arranged on the base 11. The X-direction drive unit XM includes a first screw rod 15 and a first motor 14 that is power-connected to the first screw rod 15. Specifically, a first screw 15 is rotatably connected to the base 11, and the first screw 15 is located between the X-direction slide rails 13 distributed on the left and right sides and is arranged parallel to the two X-direction slide rails 13, and the first motor 14 is located at the front end of the first screw 15. In this embodiment, the power connection between the output shaft of the first motor 14 and the front end of the first screw 15 is realized through a coupling, so that the power of the first motor 14 can be output to the first screw 15 to drive the first screw 15 to rotate. The upper end surface of the X-direction slider 21 has a plurality of fixing members 212. In this embodiment, the number of fixing members 212 is 4, which are arranged in two rows in front and back and distributed near the four corners of the X-direction slider 21. A fixing groove 212 is arranged between the front and rear rows of fixing members 212, and the fixing groove 212 extends along the Y direction. In the process of animal testing, the tested animal can be placed in the fixing groove 212, and its four legs are respectively bound to each fixing member 212, so as to fix the small animal during the test, which is convenient for subsequent endothelial reaction tests.

[0029] See also Figure 2 As shown, the platform assembly 20 also includes a plurality of X-direction slide rail connectors 23 fixedly arranged at the lower end of the X-direction slider 21. The plurality of slide rail connectors 23 are slidably matched with the X-direction slide rails 13 on the left and right sides, thereby realizing the sliding connection of the X-direction slider 21 relative to the base 11 along the X-direction. At least one first nut 22 is also fixed to the lower end surface of the X-direction slider 21, and the first screw 15 passes through the first nut 22 and meshes with the first screw 15, thereby forming a thread pair. Through the above-mentioned structural arrangement, the first motor 14 drives the first screw 15 to rotate, and the rotation of the first screw 15 drives the X-direction slider 21 fixedly connected to the first nut 22 to move along the X-direction on the X-direction slide rail 13, so that the X-direction drive unit XM drives the X-direction slider 21 to move along the X-direction relative to the base 11.

[0030] Continue to see Figure 1As shown, the Y-direction slider assembly 30 includes a Y-direction support frame 34, which is a door-shaped frame structure as a whole and extends along the Y direction and is fixed to the upper end surface of the base 11. The Y-direction support frame 34 provides support for other components as a supporting structure. A Y-direction slide rail 32 is fixedly arranged in the Y-direction support frame 34, and the Y-direction slide rails 32 in this embodiment are two and distributed along the upper and lower sides. In addition, a Y-direction drive unit YM is also arranged on the Y-direction support frame 34, including a Y-direction screw rod 33 and a second motor 31 connected to the Y-direction screw rod 33 in a power manner. Specifically, the Y-direction screw rod 33 is rotatably connected to the Y-direction support frame 34, and the Y-direction screw rod 33 is located between the two Y-direction slide rails 32, and the second motor 31 is fixedly connected to the Y-direction support frame 34 and is located at the left end side of the Y-direction screw rod 33. The output shaft of the second motor 31 is connected to the left end of the Y-direction screw rod 33 through a coupling to achieve a power connection between the two. A plurality of Y-direction slide rail connectors 44 are fixedly connected to the front end surface of the Y-direction slide block 42 , and the Y-direction slide rail connectors 44 are slidably connected to the Y-direction slide rail 32 , thereby realizing the movement of the Y-direction slide block 42 along the Y direction relative to the Y-direction slide rail.

[0031] See also Figure 3 As shown, a second nut 46 is also fixedly provided on the front end surface of the Y-direction slider 42, and the second nut 46 is located between the Y-direction slide rails 32 on the upper and lower sides. The Y-direction screw rod 33 passes through the second nut 65 and the two are meshed with each other to form a thread pair. The second motor 31 rotates to drive the second screw rod 33 to rotate, and the rotation of the second screw rod 33 drives the Y-direction slider 42 fixedly connected to the second nut 46 to move along the Y-direction on the Y-direction slide rail 32. Therefore, the Y-direction slider 42 can move along the Y-direction relative to the Y-direction slide rail 32 by driving the Y-direction drive unit YM.

[0032] Continue to see Figure 1 As shown, the Z-direction slide rail assembly 40 includes a Y-direction slider 42, and a Z-direction slide rail 45 extending along the Z-direction is fixedly arranged on the rear end surface of the Y-direction slider 42. There are two Z-direction slide rails 45 in this embodiment and they are arranged on the left and right sides of the Y-direction slider 42. In addition, a Z-direction drive unit ZM is also arranged on the Y-direction slider 42, and the Z-direction drive unit ZM includes a Z-direction screw rod 43 and a third motor 41 connected to the Z-direction screw rod 43 by power. Specifically, the third screw rod 43 extends along the Z-axis and is rotatably connected to the rear end surface of the Y-direction slider, and is located between the two Z-direction slide rails 45 arranged in the left and right directions. The third motor 41 is arranged on the upper end side of the third screw rod 43 and is connected to the third screw rod 43 to realize power transmission.

[0033] See also Figure 4As shown, the Z-direction slider assembly 50 includes a Z-direction slider 51, the front end surface of which is provided with a Z-direction slide rail connector 54, which is arranged in two rows on the left and right sides of the Z-direction slider 51 and is slidably connected to the Z-direction slide rail 45, so that the Z-direction slider 51 can slide along the Z-direction slide rail 45 in the Z direction. A Z-direction nut 55 is fixedly connected to the rear end surface of the Y-direction slider 42 and located between the Z-direction slide rail connectors 54 arranged in two rows. The upper end side of the third screw rod 43 is connected to the power of the third motor 41, and the lower end side passes through the Z-direction nut 55 and meshes with it, so that the third nut 43 and the Z-direction nut 55 form a thread pair. The rotation of the third motor 41 will drive the third screw rod 43 to rotate, and the rotation of the third screw rod 43 will cause the Z-direction slider 51 fixedly connected to the Z-direction nut 55 to slide along the Z direction on the Z-direction slide rail 45.

[0034] Therefore, in this embodiment, the X-direction slider 21 can be driven to move along the X-direction on the X-direction slide rail 13 by the X-direction driving unit XM, the Y-direction slider 42 can be driven to move along the Y-direction on the Y-direction slide rail 32 by the Y-direction driving unit YM, and the Z-direction slider 51 can be driven to move along the Z-direction on the Z-direction slide rail 45 by the Z-direction driving unit ZM. Therefore, when the syringe assembly 60 is fixedly connected to the Z-direction slider 51 and the test animal is fixed to the X-direction slider, the syringe assembly 60 can move along the X-direction and Y-direction relative to the X-direction slider to reach a specific injection point, and at the same time, the syringe assembly 60 can move along the Z-direction relative to the X-direction slider to complete the subsequent injection action.

[0035] See also Figure 5 As shown, the syringe assembly 60 includes a syringe housing 61, and the conveyor housing 61 in this embodiment is L-shaped as a whole. A syringe 64 is fixedly arranged in the syringe housing 61, and one end of the syringe 64 is connected to an injection needle 65. A piston (not shown in the figure) is arranged in the syringe 64, and the piston is connected to a drive screw 63, and a gear nut (not shown in the figure) is screwed on the outer circumference of the drive screw 63. A motor (not shown in the figure) is arranged in the conveyor housing 61, and the output shaft of the motor is connected to a gear 62, and the gear 62 is meshed with the gear nut. When the motor drives the gear 62 to rotate, the gear 62 will drive the gear nut to rotate, thereby driving the drive screw 63 to move axially, so as to push the piston to slide along the syringe 64 to complete the injection or suction action. The Z-direction slider assembly 50 also includes a fixed seat 52, which is fixedly arranged on the rear end surface of the Z-direction slider 51, and the syringe housing 61 can be embedded in the fixed seat 52 to realize the fixed connection between the conveyor assembly 60 and the Z-phase slider 51.

[0036] Continue to see Figure 5As shown, an injection pre-compression member 53 is also fixedly connected to the Z-direction slider 51. The injection pre-compression member 53 includes a connecting rod assembly 53a and a pre-compression ring 53b fixedly connected to the end of the connecting rod assembly 53a. The connecting rod assembly 53a includes a first connecting rod 531 extending along the X direction (or substantially parallel to the X direction), a second connecting rod 533 extending along the Z axis (or substantially parallel to the Y axis), and a third connecting rod 535 extending along the X direction (or substantially parallel to the X direction). Among them, the two ends of the second connecting rod 533 are fixedly connected to the first connecting rod 531 and the third connecting rod 535 respectively, so that the first connecting rod 531, the second connecting rod 533, and the third connecting rod 535 form a Z-shaped structure. One end of the first connecting rod 531 away from the second connecting rod 533 is fixedly connected to the Z-direction slider 51, so as to realize the fixed connection between the pre-compression member 53 and the Z-direction slider 51. The free end side of the third connecting rod 535 is fixedly connected with a pre-load ring 53b, and the central axis of the pre-load ring 53b is substantially parallel to or coincides with the longitudinal axis of the injection needle 65. The injection needle 65 can pass through the pre-load ring 534 from top to bottom and thus penetrate into the skin of the test animal. In the present invention, substantially parallel means that the two are parallel or the angle between the two is within plus or minus 5 degrees. Optionally, the longitudinal axis or central axis of the first connecting rod 531, the second connecting rod 533, the third connecting rod 535 and the pre-load ring 53b can also extend in other directions, as long as the injection needle 65 can pass through the pre-load ring 53b. For example, see Figure 5 As shown, when the injection needle 65 is extended along the Z axis and arranged vertically, the preload ring 53b is arranged horizontally as a whole, and its central axis is also arranged in the vertical direction, and at this time, the longitudinal axis of the second connecting rod 533 is also basically arranged in the vertical direction, that is, it is basically parallel to the central axis of the preload ring 53b. In this embodiment, the needle tip of the injection needle 64 is located above the bottom wall of the preload ring 53b, that is, the height h from the needle tip to the bottom wall of the preload ring 53b is greater than 0. Through the above arrangement, it can be ensured that when the preload ring 53b just starts to contact the skin of the test animal, the injection needle 64 does not penetrate into the animal skin. In addition, the second connecting rod 533 includes a first rod unit 5331 and a second rod unit 5332, the first rod unit 5331 is fixed or integrally arranged with the first connecting rod 531, and the second rod unit 5332 is fixed or integrally arranged with the third connecting rod 535.

[0037] See also Figure 6As shown, the end of the first rod unit 5331 is provided with a sliding groove 5331A, and the end of the second rod unit 5332 is slidably inserted into the sliding groove 5331A, so that the second connecting rod 533 constitutes a telescopic rod. One end of the elastic member 5333 is connected to the end face of the second rod unit 5332, and the other end is connected to the bottom wall of the sliding groove 5331A. The bottom wall and the upper end face of the second rod unit 5332 constitute the opposite end faces of the two, and the elastic member 5333 is arranged on the opposite end face. The second rod unit 5332 can overcome the elastic force of the spring and slide in the sliding groove 5331A, thereby realizing the telescopic movement of the second connecting rod 533.

[0038] Continue to see Figure 5 As shown, the injection pre-press 53 is further provided with a first reinforcing rod 532 and a second reinforcing rod 534. One end of the first reinforcing rod 532 is fixedly connected to the first connecting rod 531, and the other end is fixedly connected to the first rod unit 5331. One end of the second reinforcing rod 534 is fixedly connected to the second rod unit 5332, and the other end is fixedly connected to the third connecting rod 535. The first reinforcing rod 532 is used to enhance the connection strength between the first connecting rod 531 and the first rod unit 5331, and reduce the deformation amount caused by the force at the connection between the two; similarly, the second reinforcing rod 534 is used to enhance the connection strength between the third connecting rod 535 and the second rod unit 5332, and reduce the deformation amount caused by the force at the connection between the two. By providing the first reinforcing rod 532 and the second reinforcing rod 534, the amount of rotation of the first connecting rod 531 and the third connecting rod 535 around the Y-axis when the injection pre-compression member 53 is subjected to force at the pre-compression ring 534 can be reduced, thereby reducing the amount of deflection of the pre-compression ring 53b during the extrusion process, preventing the pre-compression ring 53b from causing uneven extrusion of the skin of the test animal due to deflection, and more evenly extruding the skin of the test animal near the injection point.

[0039] Combine the following Figure 1-5The use process of the auxiliary injection device 100 for the endothelial reaction test of this embodiment is described. The test animal is fixed on the X-direction slider 21, and relevant parameters such as the injection starting position coordinates, the number of injection points, the injection point arrangement direction (such as arranged along the X direction or arranged along the Y direction) and the injection point spacing distance are input into the control system (not shown in the figure). The control system automatically calculates the coordinate position of each injection point based on the above input. The control system controls the drive component to drive the X-direction slider 21 and the Y-direction slider 42 to move relative to each other so that the injection needle 65 reaches the injection starting coordinate position. The drive component drives the Z-direction slider 51 to move downward, so that the injection needle 61 and the injection pre-pressing member 53 gradually approach the skin of the test animal until the bottom wall of the pre-pressing ring 53b contacts the skin of the test animal for the first time. Since the needle tip is above the bottom wall of the pre-pressing ring 53b and the distance between the two is h, when the bottom wall of the pre-pressing ring 53b contacts the skin of the test animal for the first time, the height between the needle tip and the animal skin is also h. As the Z-direction slider 51 continues to move downward, the pre-compression ring 53b will squeeze the animal skin, and the reaction force of the squeezing force will cause the second connecting rod unit 5332 to overcome the elastic force of the elastic member 5333 and slide upward relative to the first rod unit 5331, thereby causing the second connecting rod 533 to shrink. When the shrinkage amount of the second connecting rod 533 is h, it indicates that the distance that the needle tip moves downward relative to the pre-compression ring 53b is h, and at this time, the needle tip first contacts and begins to penetrate the skin of the test animal. When the Z-direction slider 51 continues to move downward by ΔH, the depth to which the injection needle 61 penetrates the skin of the test animal is also ΔH. When ΔH reaches a predetermined value, the needle tip remains at this position, and the controller controls the motor in the syringe assembly 60 to rotate and push the piston to achieve quantitative injection. After the injection is completed, the controller controls the Z-direction slider 51 to move upward so that the needle tip is withdrawn from the body of the test animal, and then the controller controls the injection needle 61 to reach the next injection coordinate position, repeating the above injection process to complete the injection of the next injection point. In this embodiment, by setting the injection pre-compression piece 53, the skin around the injection point is squeezed before the injection needle 61 pierces the skin of the test animal, so that the skin around the injection point can be made smoother and more compact, thereby facilitating subsequent injection operations, improving the success rate of injection, and preventing injection failure due to uneven or excessively loose skin at the injection point.

[0040] In other embodiments, a pressure sensor may be provided on the lower end surface of the pre-compression ring 53b to measure the moving distance of the first rod unit 5331 relative to the second rod unit 5332. Assume that the reaction force applied by the skin to the pre-compression ring is F, the stiffness of the elastic member 5333 is K and it is in an uncompressed natural state in the initial state. When the force F detected by the pressure sensor is K*(H+ΔH), it indicates that the moving distance of the first rod unit 5331 relative to the second rod unit 5332 is H+ΔH, that is, the injection needle 61 penetrates the skin of the test animal to a depth of ΔH. At this time, the control unit may stop driving the Z-direction slider 51, thereby completing the control of the injection needle 61 penetrating the predetermined depth of the test animal's skin.

[0041] In other embodiments, a disinfectant may be provided on the lower end surface of the pre-compression ring 53b, and the disinfectant may be medical cotton soaked in alcohol, iodine or other disinfectants. Since the pre-compression ring 53b contacts the animal skin before the injection needle 61, the pre-compression ring 53b with the disinfectant may be made to perform circular or linear reciprocating motion near the injection point before injection, thereby disinfecting the injection point, so as to reduce the possibility of infection at the injection point of the test animal.

[0042] In other embodiments, a camera may be provided on the lower end surface of the third connecting rod 535 or the pre-compression ring 53b. Before the experiment begins, the operator marks the starting injection point. The camera takes a picture of the experimental animal and transmits the picture to the control system, which recognizes the image based on the captured image (convolutional neural network and deep neural network methods may be used) and calculates the coordinates of the marked point, so that the auxiliary injection device 100 can automatically realize the initial injection point alignment of the injection needle 65 according to the manual marking point, eliminating the operation process of manual initial injection point alignment.

[0043] See also Figure 7As shown, the connection mode of the syringe assembly 60 and the fixed seat 52 is described. The fixed seat 52 is provided with a fixed groove 521, one end of which has a bottom wall 5211, and the other end extends to the upper end surface of the fixed seat 52 to form a through groove. A limiting groove 522 is provided on at least one side wall of the fixed groove 521, and the limiting groove 522 is arranged parallel to the fixed groove 521. The housing 61 of the syringe assembly 60 is provided with a limiting protrusion 611 that cooperates with the limiting groove 522. Among them, the limiting protrusion 611 is composed of an elastic body and has an interference fit with the limiting groove 522. When the syringe assembly 60 needs to be installed in the fixed seat 52, after aligning the limiting protrusion 611 with the limiting groove 522, the housing 61 is slid from top to bottom along the fixed groove 521 until the bottom 612 of the housing 61 abuts against the bottom wall 5211 of the fixed groove 521. Since the limiting protrusion 611 and the limiting groove 522 are in interference fit, the injection assembly 60 can be fixedly connected to the fixing seat 52. When the injection assembly 60 needs to be disassembled, it is only necessary to overcome the friction resistance between the limiting protrusion 611 and the limiting groove 522 and slide the injection assembly 60 upward to separate it from the fixing seat 52.

[0044] The above-mentioned embodiments only express several implementation methods of the present invention, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the invention patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. The protection scope of the patent of the present invention shall be based on the attached claims.

Claims

1. An auxiliary injection device for endothelial reaction test, characterized in that: include: A base assembly (10) comprises a base (11) and an X-direction slide rail (13) arranged on the upper side of the base (11); An X-direction sliding block (21) which is slidably connected to the X-direction sliding rail (13); A Y-direction slide rail assembly (30) comprises a Y-direction support frame (34), wherein the Y-direction support frame (34) is fixedly connected to the base, and a Y-direction slide rail (32) is arranged on the Y-direction support frame (34); A Z-direction slide rail assembly (40) comprises a Y-direction slider (42) and a Z-direction slide rail (45) arranged on the rear end surface of the Y-direction slider, wherein the Y-direction slider (42) is slidably connected to the Y-direction slide rail (32); A Z-direction sliding block (51) which is slidably connected to the Z-direction sliding rail (45); A syringe assembly (60) fixedly connected to the Z-direction slider (51); A driving assembly can drive the X-direction slider (21), the Y-direction slider (42) and the Z-direction slider (51) to move in the X-direction, the Y-direction and the Z-direction respectively.

2. An auxiliary injection device for endothelial reaction test according to claim 1, characterized in that: It also includes an injection pre-compression piece (53), the syringe assembly (60) includes an injection needle (65), the injection pre-compression piece (53) includes a retractable connecting rod assembly (53a) and a pre-compression ring (53b), one end of the connecting rod assembly (53a) is fixedly connected to the Z-axis slider (51), and the other end is fixedly connected to the pre-compression ring (53b), and the injection needle (65) can pass through the pre-compression ring (53b).

3. An auxiliary injection device for endothelial reaction test according to claim 2, characterized in that: The longitudinal axis of the injection needle (65) is substantially parallel to or coincides with the central axis of the pre-compression ring (53b).

4. The auxiliary injection device for endothelial reaction test according to claim 2, characterized in that: A pressure sensor is provided on the lower end surface of the pre-compression ring (53b).

5. The auxiliary injection device for endothelial reaction test according to claim 2, characterized in that: The lower end surface of the pre-compression ring (534) is provided with a disinfection element.

6. The auxiliary injection device for endothelial reaction test according to claim 2, characterized in that: The connecting rod assembly (53a) comprises a first connecting rod (531), a second connecting rod (533), and a third connecting rod (535) which are connected in sequence, wherein the free end of the first connecting rod (531) is fixedly connected to the X-axis slider (51), and the third connecting rod (535) is fixedly connected to the pre-compression ring (53b).

7. An auxiliary injection device for endothelial reaction test according to claim 6, characterized in that: The second connecting rod (533) includes a first rod unit (5331) and a second rod unit (5332) which are slidably connected to each other, and an elastic member (5333) is also arranged between the opposite end surfaces of the first rod unit (5331) and the second rod unit (5332).

8. An auxiliary injection device for endothelial reaction test according to claim 7, characterized in that: It also includes a first reinforcing rod (532) and a second reinforcing rod (534), wherein one end of the first reinforcing rod (532) is connected to the first connecting rod (531), and the other end is connected to the first rod unit (5331), and one end of the second reinforcing rod (534) is connected to the third connecting rod (535), and the other end is connected to the second rod unit (5332).

9. The auxiliary injection device for endothelial reaction test according to claim 6, characterized in that: The longitudinal axis of the second connecting rod (533) is substantially parallel to the central axis of the pre-compression ring (53b).

10. An auxiliary injection device for endothelial reaction test according to claim 2, characterized in that: The injection pre-pressing member (53) is also provided with a camera.

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