Atomized liquid and atomizer

Abstract

The invention belongs to the field of atomized liquid, and particularly relates to atomized liquid of an atomization generating device. The atomized liquid comprises nicotine and benzoic acid, and the molar ratio of the benzoic acid to the nicotine in the atomized liquid is (1.5: 1)-(5: 1). The atomized liquid further comprises propylene glycol and glycerol, and the mass ratio of the propylene glycol to the glycerol is 1.1: 1-9: 1. Under the condition that the molar ratio of benzoic acid to nicotine is increased or the mass ratio of propylene glycol to glycerol is adjusted, the release amount of nicotine and the release efficiency of nicotine are increased. In addition, within this range, the molar ratio of benzoic acid to nicotine and the mass ratio of propylene glycol to glycerol have a synergistic effect on the release amount of nicotine and the increase in the release efficiency of nicotine.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of atomized liquid, and in particular to an atomized liquid for an atomizer. Background Art

[0002] As a substitute for traditional cigarettes, electronic cigarettes contain nicotine, a physiologically active substance, in their atomized liquid. Users inhale nicotine by smoking electronic cigarettes, thereby creating a physiological satisfaction similar to that of smoking traditional cigarettes. Current technology mainly uses nicotine salts to enhance users' satisfaction with electronic cigarettes. Nicotine salts are formed by the combination of nicotine and organic acids. The nicotine salts formed by nicotine and organic acids can reduce the volatility of nicotine and improve the transmission efficiency of nicotine to the lungs. However, when the nicotine concentration limit is below 2%, the nicotine in the nicotine salt system cannot be completely released, and the atomization efficiency of the atomized liquid to the aerosol is not high, resulting in a lot of nicotine remaining in the atomized liquid, and the nicotine in the atomized liquid is not effectively utilized. Summary of the invention

[0003] In order to solve the problem of low nicotine release in the nicotine salt system, an embodiment of the present application provides an atomizing liquid, the atomizing liquid includes propylene glycol, glycerol, nicotine, and benzoic acid, and the molar ratio of benzoic acid to nicotine in the atomizing liquid is 1.5:1-5:1.

[0004] In the atomized liquid provided in the embodiment of the present application, the molar ratio of benzoic acid to nicotine is 1.5:1-5:1. The molar ratio of benzoic acid to nicotine is within this range. The greater the molar ratio of benzoic acid to nicotine, the higher the nicotine release efficiency. At the same time, the greater the nicotine release amount, the greater the satisfaction the user gets during the process of inhaling the atomized liquid.

[0005] An embodiment of the present invention provides an atomized liquid, wherein the mass ratio of propylene glycol to glycerol in the atomized liquid is 1.1:1-9:1.

[0006] In the atomizing liquid provided in the embodiment of the present application, the mass ratio of propylene glycol to glycerol is 1.1:1-9:1. Within this range, the mass ratio of propylene glycol to glycerol is greater, the nicotine release efficiency is higher, and the nicotine release amount is greater, and the user's satisfaction in the process of inhaling the atomizing liquid is greater.

[0007] In addition, when the molar ratio of benzoic acid to nicotine is 1.5:1-5:1, and the mass ratio of propylene glycol to glycerol is 1.1:1-9:1, these two ratios have a positive effect on the increase of the release of nicotine. When the molar ratio of benzoic acid to nicotine or the mass ratio of propylene glycol to glycerol are adjusted respectively, after the release of nicotine reaches the maximum value, the molar ratio of benzoic acid to nicotine or the mass ratio of propylene glycol to glycerol are adjusted respectively, and the release of nicotine will not increase. However, when the ratio of one of them is adjusted to the maximum value, the ratio of the other is increased, and the release of nicotine can still be increased. That is, the molar ratio of benzoic acid to nicotine and the mass ratio of propylene glycol to glycerol have a synergistic effect on increasing the release of nicotine.

[0008] In the atomized liquid provided in one embodiment of the present application, the mass ratio of propylene glycol to glycerol in the atomized liquid is 2: 1-4: 1. When the mass ratio of propylene glycol to glycerol is within this range, the nicotine release efficiency is greater than 85%, the nicotine release efficiency is higher, the nicotine release amount is larger, and the user gets a stronger sense of satisfaction when using the atomized liquid for inhalation.

[0009] In the atomized liquid provided in one embodiment of the present application, the molar ratio of benzoic acid to nicotine is 1.5: 1-3: 1. When the molar ratio of benzoic acid to nicotine is within this range, the release efficiency of nicotine is higher, the amount of nicotine released is larger, and the user gets a stronger sense of satisfaction when using the atomized liquid for inhalation.

[0010] In the atomized liquid provided in one embodiment of the present application, the mass fraction of nicotine is less than 2%. The mass fraction of nicotine is less than 2%, which is not conducive to the user's addiction during the process of smoking electronic cigarettes and is more beneficial to the user's health than traditional cigarettes.

[0011] In the atomized liquid provided in one embodiment of the present application, the release efficiency of nicotine is greater than 80%. The higher the release efficiency of nicotine, the easier it is for the user to obtain a sense of satisfaction during the process of inhaling the atomized liquid.

[0012] In the atomized liquid provided in one embodiment of the present application, the molar ratio of benzoic acid to nicotine is 2:1-3:1. When the molar ratio of benzoic acid to nicotine is within this range, the release efficiency of nicotine is greater than 90%. The higher the nicotine release efficiency and the larger the nicotine release amount, the greater the satisfaction the user gets during the process of inhaling the atomized liquid.

[0013] In the atomized liquid provided in the embodiments of the present application, the molar ratio of benzoic acid to nicotine is 1.5: 1-5: 1. Within this range, the greater the molar ratio of benzoic acid to nicotine, the higher the release efficiency of nicotine, and the greater the release amount of nicotine, the stronger the satisfaction obtained by the user in the process of using this atomized liquid to draw. The mass ratio of propylene glycol and glycerol in the atomized liquid is 1.1: 1-9: 1. Within this range, the greater the mass ratio of propylene glycol and glycerol, the higher the release efficiency of nicotine, and the greater the release amount of nicotine, the stronger the satisfaction obtained by the user in the process of using this atomized liquid to draw. In addition, when the molar ratio of benzoic acid to nicotine is 1.5: 1-5: 1, and the mass ratio of propylene glycol to glycerol is 1.1: 1-9: 1, these two ratios have a positive effect on the increase in the release amount of nicotine. When the molar ratio of benzoic acid and nicotine or the mass ratio of propylene glycol and glycerol are adjusted respectively, after the release of nicotine reaches the maximum value, the release of nicotine will not increase further if the molar ratio of benzoic acid and nicotine or the mass ratio of propylene glycol and glycerol is adjusted respectively. However, when the ratio of one of them is adjusted to the maximum value, the ratio of the other is increased, and the release of nicotine can still be increased. That is, the molar ratio of benzoic acid and nicotine and the mass ratio of propylene glycol and glycerol have a synergistic effect on increasing the release of nicotine. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] One or more embodiments are exemplarily described by pictures in the corresponding drawings, and these exemplified descriptions do not constitute limitations on the embodiments. Elements with the same reference numerals in the drawings represent similar elements, and unless otherwise stated, the figures in the drawings do not constitute proportional limitations.

[0015] Figure 1 The average nicotine release per puff of the atomized liquid involved in the comparative example and each embodiment.

[0016] Figure 2 The nicotine release efficiency of the atomized liquid in the comparative example and each embodiment during multiple puffs.

[0017] Figure 3 The change in the average nicotine release after increasing the mass ratio of propylene glycol and glycerol alone in some examples is shown.

[0018] Figure 4 The change in the average nicotine release after increasing the molar ratio of benzoic acid and nicotine alone in some examples is shown. DETAILED DESCRIPTION

[0019] In order to facilitate the understanding of the present application, the present application is described in more detail below in conjunction with the accompanying drawings and specific implementation methods.

[0020] Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.

[0021] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0022] Some embodiments of the present application provide an atomizing liquid, which includes propylene glycol, glycerol, nicotine, and benzoic acid, and the molar ratio of benzoic acid to nicotine in the atomizing liquid is 1.5:1-5:1.

[0023] In the atomized liquid provided in the embodiment of the present application, the molar ratio of benzoic acid to nicotine is 1.5:1-5:1. The molar ratio of benzoic acid to nicotine is within this range. The greater the molar ratio of benzoic acid to nicotine, the higher the nicotine release efficiency. At the same time, the greater the nicotine release amount, the greater the satisfaction the user gets during the process of inhaling the atomized liquid.

[0024] An embodiment of the present invention provides an atomized liquid, wherein the mass ratio of propylene glycol to glycerol in the atomized liquid is 1.1:1-9:1.

[0025] In the atomizing liquid provided in the embodiment of the present application, the mass ratio of propylene glycol to glycerol is 1.1:1-9:1. Within this range, the greater the mass ratio of propylene glycol to glycerol, the higher the nicotine release efficiency and the greater the nicotine release amount, and the greater the satisfaction the user gets when using the atomizing liquid for inhalation.

[0026] And within this ratio range, the greater the mass ratio of propylene glycol to glycerol, the greater the molar ratio of benzoic acid to nicotine, and the higher the nicotine release efficiency. By adjusting the size of these two ratios, the release amount and release efficiency of nicotine can be controlled to meet different consumer needs.

[0027] In addition, when the molar ratio of benzoic acid to nicotine is 1.5:1-5:1, and the mass ratio of propylene glycol to glycerol is 1.1:1-9:1, these two ratios have a positive effect on the increase of the release of nicotine. When the molar ratio of benzoic acid to nicotine or the mass ratio of propylene glycol to glycerol are adjusted respectively, after the release of nicotine reaches the maximum value, the molar ratio of benzoic acid to nicotine or the mass ratio of propylene glycol to glycerol are adjusted respectively, and the release of nicotine will not increase. However, when the ratio of one of them is adjusted to the maximum value, the ratio of the other is increased, and the release of nicotine can still be increased. That is, the molar ratio of benzoic acid to nicotine and the mass ratio of propylene glycol to glycerol have a synergistic effect on increasing the release of nicotine.

[0028] The composition of the atomized liquid in the comparative examples and embodiments of the present application is shown in Table 1. In the comparative examples and embodiments, the original proportions of the components of the atomized liquid are expressed in mass fractions. Since the specific mass fractions of each component in the actual situation are affected by other components of the atomized liquid, this patent focuses on protecting the relative proportions of the four basic components in the atomized liquid, namely, the mass ratio of propylene glycol to glycerol, and the molar ratio of benzoic acid to nicotine.

[0029] The comparative example represents a common atomizing liquid composition, wherein the mass ratio of propylene glycol to glycerol is 0.93:1, and the molar ratio of benzoic acid to nicotine is 1:1. This atomizing liquid composition is widely used in commercially available atomizing liquids and is used as a benchmark for comparative reference.

[0030] Examples 1, 2, 3, and 4 are based on Example 1, in which the molar ratio of benzoic acid to nicotine is kept unchanged in the atomized liquid, and only the mass ratio of propylene glycol to glycerol is increased. Examples 5, 6, 7, and 8 are based on Example 3, in which the mass ratio of propylene glycol to glycerol is kept basically unchanged in the atomized liquid, and only the molar ratio of benzoic acid to nicotine is increased. Examples 9, 10, 11, 12, and 13 further increase the mass ratio of propylene glycol to glycerol and the molar ratio of benzoic acid to nicotine in the atomized liquid, so as to achieve a better effect of increasing the release of nicotine.

[0031] Table 1 Composition of the atomized liquid in each embodiment

[0032]

[0033]

[0034] The experiment used a ceramic atomizer as a test device, and the total mass of nicotine in the aerosol of 50 puffs of smoke was collected and tested to obtain the average nicotine release per puff. The nicotine release efficiency is defined as the nicotine release per puff of smoke / (the amount of smoke per puff of smoke*the initial nicotine concentration of the atomized liquid). The nicotine release of each embodiment is shown in Figure 1 As shown, the nicotine release efficiency is Figure 2 shown.

[0035] from Figure 1 It can be seen that, relative to the comparative example, in the examples 1 to 13, the molar ratio of benzoic acid to nicotine was increased from 1.5:1 to 5:1, and under the experimental conditions, the nicotine release amount increased from 0.125 mg / puff to 0.170 mg / puff, the nicotine release amount increased by 36%, and the nicotine release efficiency increased from 85.1% to nearly 100%.

[0036] Compared with the comparative example, increasing the mass ratio of propylene glycol and glycerol alone, or increasing the molar ratio of benzoic acid and nicotine alone, can increase the release of nicotine. In addition, adjusting the mass ratio of propylene glycol and glycerol and the molar ratio of benzoic acid and nicotine at the same time can further increase the release of nicotine, and the release efficiency of nicotine is increased to nearly 100%, or even more than 100%. Therefore, the mass ratio of propylene glycol and glycerol and the molar ratio of benzoic acid and nicotine have a synergistic effect on the release of nicotine and the improvement of the release efficiency of nicotine.

[0037] Figure 3 The changes in the average nicotine release after the mass ratio of propylene glycol and glycerol is increased separately in some examples. Among them, in Example 1, relative to the comparative example, the mass ratio of propylene glycol and glycerol is increased from 0.93:1 to 1.1:1, and the nicotine release is increased from 0.123mg / puff to 0.125mg / puff. In Example 3, relative to the comparative example, the mass ratio of propylene glycol and glycerol is increased from 0.93:1 to 2.22:1, and the nicotine release is increased from 0.123mg / puff to 0.135mg / puff, and the release is increased by about 10%, and the user's satisfaction is enhanced. It can be obtained that, when the molar ratio of benzoic acid and nicotine is constant, as the mass ratio of propylene glycol and glycerol increases, the nicotine release increases. This is because the main components of the atomized liquid in the embodiment of the present application are propylene glycol and glycerol, wherein the boiling point of propylene glycol is 188°C, and the boiling point of glycerol is 292°C, and the boiling point of the atomized liquid is related to the mass ratio of propylene glycol and glycerol. When the mass ratio of propylene glycol is larger, the boiling point of the atomized liquid is lower, so when the atomization temperature provided by the laboratory test equipment is constant, when the mass ratio of propylene glycol and glycerol is larger, the boiling point of the atomized liquid is lower, so the atomized liquid is easier to atomize. In addition, the latent heat of vaporization of propylene glycol is lower, so the more mass that can be atomized per unit energy, that is, the larger the amount of smoke, there is a significant positive correlation between the amount of nicotine released and the amount of smoke, therefore, increasing the proportion of propylene glycol will lead to an increase in nicotine release.

[0038] Figure 4 The changes in the average nicotine release after increasing the molar ratio of benzoic acid and nicotine in some examples are given by Figure 4 It can be seen that in Example 3, Example 5, Example 6, and Example 8, the mass ratio of propylene glycol to glycerol is controlled at about 2.2:1, and the molar ratio of benzoic acid to nicotine is increased from 1:1 to 2.66:1. In this process, the release of nicotine increases from 0.135 mg / puff to 0.152 mg / puff, the release of nicotine is further increased by about 13%, and the release efficiency of nicotine increases from 86.0% to 96.5%. It can be obtained that under the condition of a certain mass ratio of propylene glycol to glycerol, increasing the molar ratio of benzoic acid to nicotine increases the release of nicotine, increases the release efficiency of nicotine, and enhances user satisfaction. This is because, when the molar ratio of benzoic acid to nicotine is less than 1, benzoic acid and nicotine react to generate protonated nicotine. When the molar ratio of benzoic acid to nicotine is greater than 1, benzoic acid will further react with nicotine to generate diprotonated nicotine, which greatly strengthens the molecular binding force between benzoic acid and nicotine. The boiling point of benzoic acid is 249°C, and the boiling point of nicotine is 247°C. The boiling points of benzoic acid and nicotine are very close, and they have consistent atomization characteristics. Therefore, in addition to the heating and atomization of nicotine itself, the excess benzoic acid will also carry out the bound nicotine while atomizing. Therefore, the greater the molar ratio of benzoic acid to nicotine, the greater the amount of nicotine released, and the greater the release efficiency of nicotine.

[0039] In Examples 5 to 11, the molar ratio of benzoic acid to nicotine is 2:1, and the mass ratio of propylene glycol to glycerol is 2.19:1 to 3.70:1. Within this range, the release of nicotine is 0.136 mg / puff-0.155 mg / puff, and the release efficiency of nicotine is 88.5%-99%, which is a high release efficiency of nicotine. In actual operation, the mass ratio of propylene glycol to glycerol in the atomized liquid is often 2:1-4:1. According to the suction test of professionals, within this range, the user gets a stronger sense of satisfaction in the process of using this atomized liquid.

[0040] In Examples 5 to 8, the mass ratios of propylene glycol and glycerol are 2.19:1 and 2.13:1, respectively, which are approximately the same. The molar ratio of benzoic acid and nicotine increases from 1.5:1 to 2.66:1. Within this range, the release amount of nicotine is 0.136 mg / puff-0.152 mg / puff, and the release efficiency of nicotine is 88.5%-96.5%. In actual operation, the molar ratio of benzoic acid and nicotine in the atomized liquid is often taken as 1.5:1-3:1. According to the suction test by professionals, within this range, the user gets a stronger sense of satisfaction when using the atomized liquid.

[0041] In Example 6 and Example 8, the mass ratio of propylene glycol to glycerol is 2.17:1 and 2.13:1 respectively, and the molar ratio of benzoic acid to nicotine is increased from 2:1 to 2.66:1. Within this range, the release amount of nicotine is 0.145mg / puff-0.152mg / puff, and the release efficiency of nicotine is 90.6%-96.5%. In actual operation, the molar ratio of benzoic acid to nicotine in the atomized liquid is often 2:1-3:1. According to the suction test of professionals, within this range, the user gets a stronger sense of satisfaction in the process of using this atomized liquid. The molar ratio of benzoic acid to nicotine is 2:1-3:1, which is a better choice for nicotine release and user satisfaction.

[0042] In addition, in Example 6, relative to the comparative example, the mass ratio of propylene glycol and glycerol was increased from 0.93:1 to 2.17:1, the molar ratio of benzoic acid and nicotine was increased from 1:1 to 2:1, the release of nicotine was increased from 0.123 mg / puff to 1.145 mg / puff, and the release efficiency of nicotine was increased from 85.1% to 90.6%. It can be obtained that the release of nicotine was increased by about 20% by increasing the mass ratio of propylene glycol and glycerol and the molar ratio of benzoic acid and nicotine respectively. In Example 10, relative to the comparative example, the mass ratio of propylene glycol and glycerol was increased from 0.93:1 to 2.76:1, the molar ratio of benzoic acid was increased from 1:1 to 2.66:1, the release of nicotine was increased from 0.123 mg / puff to 0.156 mg / puff, and the release efficiency of nicotine was increased from 85.1% to 101.7%. (The reason why the release efficiency of nicotine is greater than 100% is that the volatilization rates of the various components in the atomized liquid are different. In the early stage of inhalation, the volatilization rate of nicotine is relatively large, which greatly increases the release amount of nicotine in the atomized liquid in the early stage of inhalation. In the later stage, due to the decrease in the nicotine concentration in the atomized liquid, the release amount of nicotine in the atomized liquid in the later stage of inhalation is relatively small.) Example 6 and Example 10 show that when the mass ratio of propylene glycol and glycerol and the molar ratio of benzoic acid and nicotine are increased at the same time, the release amount of nicotine and the release efficiency of nicotine can be significantly improved. Therefore, the mass ratio of propylene glycol and glycerol and the molar ratio of benzoic acid and nicotine have a synergistic effect in improving the release amount of nicotine and the release efficiency of nicotine.

[0043] Professionals inhaled the atomized liquids of the comparative example and Examples 6 to 10, and the results showed that the atomized liquids of Examples 6 to 10 had a significantly improved sense of satisfaction compared with Example 1 when the mass fraction of nicotine remained the same. Therefore, when the mass ratio of propylene glycol to glycerol was within the range of 2:1-3:1, and the molar ratio of benzoic acid to nicotine was within the range of 2:1-3:1, the nicotine release amount was within the range of 0.145 mg / puff-0.156 mg / puff, and the nicotine release efficiency was within the range of 90.6%-101.7%, and the user's sense of satisfaction was relatively strong.

[0044] Since the current international standard stipulates that the concentration of nicotine in the atomized liquid is not higher than 2%, the mass fraction of nicotine in the embodiments of the present application is less than 2%. Compared with the case where the mass fraction of nicotine is greater than 2%, the nicotine in the embodiments of the present application is less harmful to the user.

[0045] The atomized liquid provided by the embodiment of the present application can be obtained, and the molar ratio of benzoic acid and nicotine is 1.5: 1-5: 1. Within this range, the greater the molar ratio of benzoic acid and nicotine, the higher the release efficiency of nicotine, and the greater the release amount of nicotine, and the stronger the satisfaction obtained by the user in the process of using this atomized liquid to draw. The mass ratio of propylene glycol and glycerol in the atomized liquid is 1.1: 1-9: 1. Within this range, the greater the mass ratio of propylene glycol and glycerol, the higher the release efficiency of nicotine, and the greater the release amount of nicotine, and the stronger the satisfaction obtained by the user in the process of using this atomized liquid to draw. In addition, when the molar ratio of benzoic acid and nicotine is 1.5: 1-5: 1, and the mass ratio of propylene glycol and glycerol is 1.1-9: 1, these two ratios have a positive effect on the increase of the release amount of nicotine. When the molar ratio of benzoic acid and nicotine or the mass ratio of propylene glycol and glycerol are adjusted respectively, after the release of nicotine reaches the maximum value, the release of nicotine will not increase further if the molar ratio of benzoic acid and nicotine or the mass ratio of propylene glycol and glycerol is adjusted respectively. However, when the ratio of one of them is adjusted to the maximum value, the ratio of the other is increased, and the release of nicotine can still be increased. That is, the molar ratio of benzoic acid and nicotine and the mass ratio of propylene glycol and glycerol have a synergistic effect on increasing the release of nicotine.

[0046] In addition, the atomized liquid in the embodiment of the present application can also include other ingredients, such as flavors, additives, etc. Wherein, the flavor can be a combination of ethyl butyrate, ethyl 2-methylbutyrate, leaf alcohol, isoamyl acetate, ethyl acetate, ethyl caproate, hexyl acetate, isoamyl butyrate, allyl caproate, isoamyl isovalerate, butyl butyrolactate, vanillin, propyl decalactone, triethyl citrate, and vanillin propylene glycol acetal. The additive can be cinnamaldehyde, menthol, benzyl alcohol, vanillin, eugenol, p-anisaldehyde, ethyl cinnamate, maltol, ethyl maltol, triacetin, benzaldehyde and menthone, etc. The ingredients of flavors and additives in the atomized liquid can be selected according to the different tastes of users.

Claims

1. An atomized liquid comprising propylene glycol, glycerol, nicotine and benzoic acid, characterized in that: The molar ratio of the benzoic acid to the nicotine in the atomized liquid is 1.5:1-5:

1.

2. The atomized liquid according to claim 1, characterized in that: The mass ratio of the propylene glycol to the glycerol is 1.1:1-9:

1.

3. The atomized liquid according to claim 2, characterized in that: The mass ratio of the propylene glycol to the glycerol is 2:1-4:

1.

4. The atomized liquid according to claim 1, characterized in that: The molar ratio of the benzoic acid to the nicotine is 1.5:1-3:

1.

5. The atomized liquid according to claim 1, characterized in that: The mass fraction of the nicotine is not higher than 2%.

6. The atomized liquid according to claim 1, characterized in that: The nicotine release efficiency is greater than 80%.

7. The atomized liquid according to claim 1, characterized in that: The molar ratio of the benzoic acid to the nicotine is 2:1-3:

1.

8. The atomized liquid according to claim 7, characterized in that: The nicotine release efficiency is greater than 90%.

9. The atomized liquid according to claim 3, characterized in that: The nicotine release efficiency is greater than 85%.

10. An atomizer, characterized in that: The atomizer comprises the atomized liquid according to any one of claims 1-9.

Images