Plasma activation gas wound treatment device and method

Abstract

The invention discloses a plasma activation gas wound treatment device and method.The method comprises a plasma generator, a treatment cavity, a high-voltage power module, an air pump and a control module, the treatment cavity comprises an air return channel and an air supply channel, the air return channel is communicated with an air inlet of the plasma generator through the air pump, and the air supply channel is communicated with an air outlet of the plasma generator through the air pump; the air supply passage is communicated with an air outlet of the plasma generator; the high-voltage power supply module is electrically connected with the plasma generator and the control module, the control module controls the plasma generator to be in an intermittent working state or a continuous working state by controlling the on-off of the high-voltage power supply module, and the plasma generator generates a first type of plasma activation gas in the intermittent working state; a second type of plasma activation gas is generated in a continuous working state; the treatment effect of plasma activated gas is enhanced, the utilization rate of active particles is increased, and the requirements for efficient disinfection and wound healing promotion are met.

Description

Technical Field

[0001] The invention belongs to the field of plasma biomedical technology, and in particular relates to a plasma activated gas trauma treatment device and method. Background Art

[0002] Trauma is often caused by traffic accidents, sharp injuries, surgery, etc., posing a serious threat to human health. Trauma treatment generally includes several key functions such as debridement, disinfection, hemostasis, and healing promotion. However, the current main drug therapies have problems such as single function, poor broad-spectrum bactericidal ability, and easy drug resistance, which makes it difficult to fully meet the treatment needs of patients. Therefore, it is particularly important to develop a new multifunctional integrated trauma treatment technology. In recent years, atmospheric pressure cold plasma (referred to as plasma) has shown great application potential in the field of trauma treatment. The active gas generated by plasma excitation (referred to as plasma activated gas) contains a large number of reactive oxygen species (ROS) and reactive nitrogen species (RNS) with biomedical effects, such as O3, NO, N2O5, etc., which can induce tissue regeneration and effectively inactivate a variety of pathogenic microorganisms at appropriate doses, and it is difficult for microorganisms to develop drug resistance. In addition, the temperature of plasma activated gas is close to room temperature, and it can act on complex wound sites in a large range and without dead ends with the help of gas diffusion.

[0003] Existing discharge plasma equipment usually uses rare gases such as He and Ar as working gases, which is not only costly, but also requires the installation of gas cylinders, resulting in a large size of the equipment. Air discharge plasma uses air as the working gas, which can use local materials to achieve economical and efficient production of plasma-activated gas rich in ROS and RNS. However, there are three completely different product modes in air discharge: an ozone mode dominated by O3, a nitrogen oxide mode dominated by NO, and a transition mode in which O3 and NO coexist when the two modes are transformed into each other. High-valent nitrogen oxides such as N2O5 are only generated in the transition mode, which makes the transition mode have a higher microbial inactivation efficiency than the other two modes, while NO in the nitrogen oxide mode plays a vital role in wound healing processes such as cell proliferation, migration, differentiation and apoptosis. However, air plasma is extremely sensitive to discharge conditions, which makes it difficult to maintain the transition mode stably and easily convert to the nitrogen oxide mode, making it difficult to meet the needs of long-term and efficient sterilization. In addition, the leakage of O3 and nitrogen oxides can also cause potential harm to human health and the environment, which may affect the treatment effect and reduce the acceptance of medical workers and patients. Summary of the invention

[0004] (I) Purpose of the invention

[0005] The purpose of the present invention is to provide a plasma activated gas wound treatment device and method, which adjusts the type and concentration of active substances in the internal circulation activated gas by controlling the intermittent or continuous working state of the plasma activated gas generator, thereby enhancing the therapeutic effect of the plasma activated gas, improving the utilization rate of active particles, and meeting the needs of efficient disinfection and promoting wound healing.

[0006] (II) Technical solution

[0007] To solve the above problems, the first aspect of the present invention provides a plasma activated gas trauma treatment device, comprising: a plasma generator, a treatment chamber, a high voltage power supply module, an air pump and a control module, wherein:

[0008] The treatment chamber comprises an air return passage and an air supply passage, the air return passage is connected to the air inlet of the plasma generator through an air pump, the air supply passage is connected to the air outlet of the plasma generator, and the plasma generator and the air pump are both arranged outside the treatment chamber;

[0009] The high-voltage power supply module is electrically connected to the plasma generator and the control module respectively, and the control module controls the plasma generator to be in an intermittent working state or a continuous working state by controlling the on and off of the high-voltage power supply module;

[0010] The plasma generator generates a first type of plasma activated gas in an intermittent working state, wherein the first type of plasma activated gas includes O3 and N2O5, which is used to disinfect the part to be treated in the treatment chamber;

[0011] The plasma generator generates a second type of plasma activated gas in a continuous working state, wherein the second type of plasma activated gas includes NO and is used to promote the healing of the part to be treated in the treatment chamber.

[0012] Furthermore, the intermittent working state includes: in a first time period, discharge and flow of working gas are simultaneously performed in the plasma generator, and in a second time period, discharge is stopped while the working gas is circulated in the plasma generator, and the first time period and the second time period are sequentially connected and circulated.

[0013] Furthermore, the continuous working state includes: discharge and flow of working gas are simultaneously performed in the plasma generator.

[0014] Furthermore, the trauma treatment device also includes a temperature regulating module and a flow rate regulating module, and the control module is electrically connected to the temperature regulating module and the flow rate regulating module respectively.

[0015] Furthermore, the temperature regulating module includes a refrigeration device and a heating device. When the plasma generator switches from an intermittent working state to a continuous working state, the control module starts the heating device to heat up the environment around the plasma generator; when the plasma generator switches from a continuous working state to an intermittent working state, the control module starts the refrigeration device to cool down the environment around the plasma generator.

[0016] Furthermore, when the plasma generator switches from an intermittent working state to a continuous working state, the control module controls the flow rate regulation module to reduce the flow rate of the air pump; when the plasma generator switches from a continuous working state to an intermittent working state, the control module controls the flow rate regulation module to increase the flow rate of the air pump.

[0017] Furthermore, the treatment chamber also includes a three-way valve, and the three-way valve is arranged between the return air passage and the air pump.

[0018] Furthermore, the three-way valve is provided with a suspended end, and the suspended end is introduced into the working gas outside the treatment chamber, including:

[0019] During the treatment process, the plasma generator is turned on, the suspended end is turned on, and the gas pump inhales the working gas while recovering the plasma activation gas. The treatment process includes the intermittent working state and the continuous working state of the plasma generator;

[0020] When the treatment is finished, the plasma generator is turned off, the suspended end is closed, and the gas pump only recycles the plasma activated gas.

[0021] Furthermore, the total content of O3 and N2O5 accounts for more than 55% of the total concentration of active substances in the first type of plasma activated gas, and the content of NO accounts for more than 35% of the total concentration of active substances in the second type of plasma activated gas.

[0022] Another aspect of the present invention further provides a method of treating a wound using a plasma activated gas wound treatment device, wherein the method uses any one of the plasma activated gas wound treatment devices described above for treatment, and the method comprises:

[0023] The plasma generator is set to an intermittent working state, and the suspended end of the three-way valve is opened to generate a first type of plasma activated gas, and the first type of plasma activated gas is input into the treatment chamber through the gas supply passage to disinfect the treatment site, and the plasma activated gas is recovered through the gas return passage at the same time, and the intermittent working state runs for 0-30 minutes, wherein the first type of plasma activated gas includes O3 and N2O5;

[0024] After the intermittent working state is finished, the plasma generator is controlled to switch to the continuous working state, the suspended end of the three-way valve is opened, and the second type of plasma activated gas is generated. The second type of plasma activated gas is input into the treatment chamber through the gas supply passage to promote the healing of the treated part, and the plasma activated gas is recovered through the gas return passage. The continuous working state runs for 0-30 minutes, wherein the second type of plasma activated gas includes NO;

[0025] After the continuous working state is finished, the suspended end of the three-way valve is closed, the plasma generator 300 is turned off, and the treatment is finished.

[0026] (III) Beneficial effects

[0027] The present invention provides a plasma activated gas wound treatment device and method. The device adopts a time-sharing controlled internal circulation mode to recycle the generated plasma activated gas and further activate it as a working gas, which can avoid the harm caused by the leakage of O3 and nitrogen oxides, and at the same time improve the concentration and generation efficiency of active particles. In addition, the continuous operation of the internal circulation will cause the concentration of nitrogen oxides in the activated gas to gradually increase, thereby greatly reducing the yield of high-valent nitrogen oxides, and finally weakening the disinfection and sterilization ability of the plasma activated gas. The present invention controls the plasma activated gas generator to work intermittently or continuously to adjust the concentration of nitrogen oxides in the internal circulation activated gas, and combines the temperature and flow rate adjustment module to adjust the working environment temperature and the working gas flow rate, so as to achieve the stable conversion of the plasma activated gas generator transition mode and nitrogen oxide mode. Among them, the high-valent nitrogen oxides generated in the transition mode can kill the bacteria in the wound, and the NO generated in the nitrogen oxide mode can promote wound healing, thereby developing a method for highly efficient disinfection and wound healing. The specific principle is that the control module in the device controls the plasma generator to be in an intermittent working state or a continuous working state. The plasma generator generates a first type of plasma activated gas containing O3 and N2O5 in the intermittent working state, which is used to disinfect the treated part. The plasma generator generates a second type of plasma activated gas containing NO in the continuous working state, which is used to promote the healing of the treated part. The first type of plasma activated gas and the second type of plasma activated gas enter the gas supply passage of the treatment chamber through the gas outlet of the plasma generator and act on the treated part. During the treatment process, by switching the plasma generator to be in an intermittent working state or a continuous working state, the therapeutic effect of the plasma activated gas can be enhanced, the utilization rate of the active particles can be improved, and the needs of efficient disinfection and promotion of wound healing can be met. The treatment chamber includes a return gas passage, and the internal circulation design gas path recycles the plasma activated gas that has treated the wound in the treatment chamber, which can prevent the gas and active particles from diffusing into the atmosphere in large quantities, and reduce the potential harm to human health and the environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the overall structure of a plasma activated gas trauma treatment device of the present invention;

[0029] Figure 2 It is a schematic diagram of the partial structure of the plasma activated gas wound treatment device of the present invention (a schematic diagram of the circuit and gas path connection between the gas pump, the plasma activated gas generator and the treatment chamber);

[0030] Figure 3 This is a diagram showing the sterilization effect of the plasma activated gas wound treatment method of the present invention on Staphylococcus aureus.

[0031] Reference numerals:

[0032] 100. Air pump; 200. High-voltage power supply module; 300. Plasma generator (plasma activated gas generator); 310. Outer ring electrode; 320. Inner ring electrode; 330. Quartz dielectric layer; 340. Heat sink; 400. Treatment chamber; 410. Air supply passage; 420. Air return passage; 421. Disposable filter structure; 430. Input end; 440. Output end; 450. Three-way valve; 500. Temperature adjustment module; 600. Flow rate adjustment module; 700. Control module. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings. It should be understood that these descriptions are only exemplary and are not intended to limit the scope of the present invention. In addition, in the following description, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0034] like Figure 1 As shown, the present invention provides a plasma activated gas trauma treatment device, comprising: a plasma generator 300, a treatment chamber 400, a high voltage power supply module 200, an air pump 100 and a control module 700, wherein:

[0035] The treatment chamber 400 includes an air supply passage 410 and an air return passage 420. The plasma generator 300 and the air pump 100 are arranged outside the treatment chamber 400. The air return passage 420 is connected to the air inlet of the plasma generator 300 through the air pump 100, and the air supply passage 410 is connected to the air outlet of the plasma generator 300. The treatment chamber 400 has good air tightness. The treatment chamber can be made of an airtight rigid material, such as an acrylic material, or a soft airtight flexible polymer material, such as a plastic bag, preferably a plastic bag. The treatment chamber separates the internal equipment from the external instruments by bagging. The treatment chamber 400 delivers the plasma activated gas generated by the plasma generator 300 to the treatment site through the air supply passage 410, and recovers the plasma activated gas in the treatment chamber 400 through the air return passage 420. The treatment sites include but are not limited to feet, hands, groin, etc. The discharge form of the plasma generator 300 includes but is not limited to corona discharge and dielectric barrier discharge, and the discharge structure includes but is not limited to a needle-tube structure and a dielectric barrier structure. A disposable filter structure 421 is also provided on the return air passage 420 to filter out impurities such as effusion, scab, and skin tissue at the wound site.

[0036] Furthermore, an input end 430 and an output end 440 may be provided in the treatment chamber 400. At this time, one end of the gas supply passage 410 is connected to the gas outlet of the plasma generator 300, and the other end is connected to the input end 430. The generated plasma activated gas may be further transported to act on the treatment site through the input end 430. At this time, one end of the return gas passage 420 is connected to the air pump 100, and the other end is connected to the output end 440, that is, the plasma activated gas in the treatment chamber is recovered through the output end 440 and then enters the return gas passage 420.

[0037] The treatment chamber 400 further includes a three-way valve 450, which is disposed inside the treatment chamber 400 and between the return gas passage 420 and the air pump 100. The common end of the three-way valve 450 is connected to the air inlet of the air pump 100, and one of the other two ends is connected to the return gas passage 420 for recovering the plasma activated gas in the treatment chamber 400, and the other end is a suspended end, which adjusts the gas pressure in the treatment chamber 400 by introducing the working gas outside the treatment chamber 400, including the treatment process and the non-treatment process, as follows:

[0038] During the treatment process, the plasma generator 300 is turned on, the suspended end is turned on, and the gas pump 100 inhales the working gas while recovering the plasma activation gas. The treatment process includes the intermittent working state and the continuous working state of the plasma generator 300;

[0039] When the treatment is finished (non-treatment process), the plasma generator 300 is turned off, the suspended end is closed, and the gas pump 100 only recycles the plasma activated gas.

[0040] like Figure 1As shown, the high-voltage power supply module 200 is electrically connected to the plasma generator 300 and the control module 700 respectively. The control module 700 includes a control panel and an internal control circuit, which is used for selecting and controlling the device working mode and the working state of each part. The types of high-voltage power supply modules 200 include but are not limited to AC sinusoidal high-voltage power supply, pulse high-voltage power supply, DC high-voltage power supply, etc. The control module 700 controls the plasma generator 300 to be in an intermittent working state or a continuous working state by controlling the on and off of the high-voltage power supply module 200; there are 5 buttons on the device panel of the control module: disinfection mode, healing mode, start / stop, +, -, the disinfection mode corresponds to the intermittent working state of the plasma generator 300, the healing mode corresponds to the continuous working state of the plasma generator 300, and + and - are used to set the processing time. Before starting the device, set the working time of the two modes respectively. After the setting is completed, press the "start / stop" button to start the device. By default, the disinfection mode is performed first, and the healing mode is performed later. The plasma generator 300 generates a first type of plasma activated gas in an intermittent working state, and the first type of plasma activated gas is used to disinfect the part to be treated in the treatment chamber 400; the intermittent working state includes: in a first time period, the plasma generator 300 simultaneously discharges and circulates the working gas, and in a second time period, the plasma generator 300 circulates the working gas and stops discharging, and the first time period and the second time period are sequentially connected and circulated back and forth. The principle of setting the intermittent working state of the present device is that when the air discharge cycle works continuously, the concentration of nitrogen oxides in the treatment chamber gradually increases, causing ozone and N2O5 to gradually disappear. Therefore, in the intermittent working state, after discharging for a period of time, when ozone and N2O5 are about to disappear, the discharge is stopped, and the working gas is circulated to reduce the concentration of nitrogen oxides in the treatment chamber, so that it returns to the state before the discharge, and then the discharge is resumed to generate ozone and N2O5. In this intermittent state, the first time period is set to, for example, 45 seconds, and the second time period is set to, for example, 30 seconds. The reason for this setting is that when the gas phase product of the device is measured by a Fourier infrared spectrometer (FTIR), the key gas product N2O5 that realizes the disinfection function disappears when it works up to 45 seconds, and the shortest rest time required to produce the same amount of the gas again is 30 seconds. However, the running time and the time of stopping the discharge will change according to the changes in temperature and humidity. For example, when the temperature is reduced, the running time will be extended and the time of stopping the discharge will be shortened. The first type of plasma activated gas includes O3 and N2O5 with disinfection function. O3 and N2O5 are active substances, and the sum of their contents accounts for more than 55% of the total concentration of active substances in the first type of plasma activated gas, for example, 60%.

[0041] The plasma generator 300 generates a second type of plasma activated gas in a continuous working state, and the second type of plasma activated gas is used to promote the healing of the part to be treated in the treatment chamber 400. The continuous working state includes: the plasma generator 300 simultaneously discharges and circulates the working gas. The second type of plasma activated gas includes NO with a healing function, which is an active substance, and its content accounts for more than 35% of the total concentration of active substances in the second type of plasma activated gas, for example, 40%.

[0042] Furthermore, the wound treatment device further comprises a temperature regulating module 500 and a flow rate regulating module 600, and the control module 700 is electrically connected to the temperature regulating module 500 and the flow rate regulating module 600, respectively. The plasma activated gas wound treatment device of the present invention adopts a time-sharing control mechanism, so that it can work in an intermittent or continuous mode according to demand, and cooperates with the temperature regulating module 500 and the flow rate regulating module 600 to achieve stable conversion between different working modes. The temperature regulating module 500 comprises a refrigeration device and a heating device, and the refrigeration device comprises a semiconductor refrigeration sheet, a water cooling module and a heat dissipation fan. When the plasma generator 300 switches from the intermittent working state to the continuous working state, the control module 700 starts the heating device to heat up the environment around the plasma generator 300; the design principle here is: if the treatment only requires the disinfection mode (intermittent working state), the low temperature environment is advantageous, but if the healing mode (continuous working state) is required at this time, the temperature is too low to quickly switch modes. At this time, the temperature adjustment module is required to heat up and turn the area around the plasma generator 300 into a local high temperature environment to promote the mode conversion process. Similarly, when the plasma generator 300 switches from the continuous working state to the intermittent working state, the control module 700 starts the refrigeration device to cool down the environment around the plasma generator 300, that is: if the treatment only requires the healing mode, the high temperature environment is advantageous. If the disinfection mode is to be entered, the temperature adjustment module needs to start cooling tools such as cooling fans or cooling sheets to form a local low temperature environment around the plasma generator 300. The temperature adjustment module in the present invention sets an optimal working temperature, for example, 27° C., and adjusts based on the optimal working temperature so that the working temperature inside the device is always maintained near the optimal working temperature.

[0043] Furthermore, when the plasma generator 300 is switched from the intermittent working state to the continuous working state, the control module 700 controls the flow rate regulating module 600 to reduce the flow rate of the air pump 100 to ensure that the output of NO remains unchanged. In this step, the combination of temperature regulation and flow rate regulation can also keep the product type and output stable. Similarly, when the plasma generator 300 is switched from the continuous working state to the intermittent working state, the control module 700 controls the flow rate regulating module 600 to increase the flow rate of the air pump 100 to ensure that the output of N2O5 remains unchanged.

[0044] like Figure 2 As shown, the discharge form of the plasma generator 300 is a micro-gap coaxial annular dielectric barrier discharge, which includes: an outer ring electrode 310, an inner ring electrode 320, a quartz dielectric layer 330, a heat sink 340, an air inlet and an air outlet; wherein, a quartz dielectric layer 330 is fixed to the inner wall of the outer ring electrode 310, and the air introduced between the quartz dielectric layer 330 and the inner ring electrode 320 is ionized into plasma; the outer ring electrode 310 is grounded, and the inner ring electrode 320 is connected to a voltage, the voltage is AC13kV; the gap (discharge gap) between the inner ring electrode 320 and the quartz dielectric layer 330 is 0.4mm, the thickness of the quartz dielectric layer 330 is 1.6mm, and the length of the discharge area is 110mm; air is introduced from the air inlet, and the discharge generates a plasma-activated gas with a disinfection or healing function, which is then introduced into the treatment chamber 400 to treat the part to be treated. The air pump 100 uses ambient air, has a rated voltage of 24V, and a maximum gas flow rate of 11.5L / min.

[0045] Another aspect of the present invention provides a method for treating a wound using the plasma activated gas wound treatment device described in any one of the above descriptions, the method comprising the following steps:

[0046] S1, setting the plasma generator 300 to an intermittent working state, opening the suspended end of the three-way valve 450, generating a first type of plasma activated gas, the first type of plasma activated gas is input into the treatment chamber 400 through the gas supply passage 410, and the treatment site is disinfected, and the plasma activated gas is recovered through the gas return passage 420, the intermittent working state operation time is 0-30 minutes (this mode is not operated when the operation time is 0), wherein the first type of plasma activated gas includes O3 and N2O5;

[0047] S2, after the intermittent working state is finished, the plasma generator 300 is controlled to switch to the continuous working state, the suspended end of the three-way valve 450 is opened, and the second type of plasma activated gas is generated, and the second type of plasma activated gas is input into the treatment chamber 400 through the gas supply passage 410 to promote the healing of the treated part, and the plasma activated gas is recovered through the gas return passage 420, and the continuous working state running time is 0-30 minutes (when the running time is 0, this mode is not run, that is, when the two modes are different, the intermittent working state or the continuous working state running time can be selected to be 0), wherein the second type of plasma activated gas includes NO;

[0048] S3. After the continuous working state is finished, the suspended end of the three-way valve 450 is closed, the plasma generator 300 is turned off, and after the air pump runs for 3-5 minutes, the plasma activated gas trauma treatment device stops running and the treatment is finished.

[0049] Repeat steps S1, S2, and S3 to perform the next treatment cycle. During the treatment process, when the plasma generator 300 switches from the intermittent working state to the continuous working state, the control module 700 starts the heating device to heat the environment around the plasma generator 300, and at the same time, the control module 700 controls the flow rate adjustment module 600 to reduce the flow rate of the air pump 100 to ensure that the output of NO remains unchanged; when the plasma generator 300 switches from the continuous working state to the intermittent working state, the control module 700 starts the refrigeration device to cool the environment around the plasma generator 300, and at the same time, the control module 700 controls the flow rate adjustment module 600 to increase the flow rate of the air pump 100 to ensure that the output of N2O5 remains unchanged.

[0050] Combine the following Figure 3 , illustrating the bactericidal effect of the plasma activated gas wound treatment method of the present invention on Staphylococcus aureus, the specific treatment method is:

[0051] The bacterial solution volume was 200 μL and OD 600 A Staphylococcus aureus liquid of about 1 is placed in the treatment chamber 400, and the internal circulation plasma activated gas wound treatment device is turned on to perform air blowing treatment in the disinfection mode (intermittent working state), and the treatment time is 5 minutes, 10 minutes and 20 minutes respectively. By measuring the number of Staphylococcus aureus in the solution, it can be found that when the treatment time is 5 minutes, the device has a sterilization effect of 1 order of magnitude on the bacterial liquid; when the treatment time is 10 minutes, the device has a sterilization effect of 3 orders of magnitude on the bacterial liquid; when the treatment time is 20 minutes, the bacteria can be completely killed.

[0052] The present invention relates to a plasma activated gas wound treatment device and method. The device adopts an internal circulation design, introduces plasma activated gas from the gas supply passage and the input end into the treatment chamber for treatment, and recovers and reuses the plasma activated gas through the output end and the return gas passage. The three-way valve arranged inside the treatment chamber adjusts the gas pressure of the treatment chamber by opening and closing the suspended end to promote the penetration and absorption of active particles. The present invention also performs time-sharing regulation on the plasma activated gas generator, so that it works in intermittent or continuous mode according to demand, and cooperates with the temperature regulation module and the flow rate regulation module to achieve stable conversion between different working modes: the plasma activated gas generated in the intermittent working mode is rich in O3 and N2O5, which can effectively sterilize and disinfect; while the continuous working mode produces activated gas rich in NO, which helps to promote wound healing. The present invention realizes the integration of efficient disinfection and healing promotion functions, while avoiding the potential harm to human health and the environment caused by the leakage of O3 and nitrogen oxides, and has the following advantages:

[0053] 1. The internal circulation gas circuit design consisting of the gas supply passage and the gas return passage in the treatment chamber will recycle the plasma activated gas that has treated the wound in the treatment chamber, which not only helps to enhance the treatment effect of the plasma activated gas and improve the utilization rate of active particles, but also can effectively prevent the gas and active particles from diffusing into the atmosphere in large quantities, thereby reducing the potential impact on patients, medical workers and the environment.

[0054] 2. By controlling the plasma activated gas generator to work intermittently or continuously, the conversion of the plasma activated gas generator to the disinfection mode (transition mode) and the healing mode (nitrogen oxide mode) is realized. Among them, the intermittent operation of the plasma activated gas generator solves the problem that the continuous operation of the internal circulation causes the transition mode to be quickly converted into the nitrogen oxide mode. When the plasma activated gas generator works continuously, it is in the nitrogen oxide mode.

[0055] 3. The temperature regulation module can adjust the working environment temperature, so that the device can ensure that the healing mode is quickly transformed and stabilized in the nitrogen oxide mode by heating in a low-temperature environment, and can also ensure that the disinfection mode works stably in the transition mode by cooling in a high-temperature environment, offsetting the impact of the ambient temperature on the device and enhancing the working stability and environmental adaptability of the device.

[0056] 4. The present invention uses only a single plasma activated gas generator to achieve free conversion of discharge modes, which reduces the size of the device and reduces production costs. The use of air as the working gas also makes the device portable.

[0057] It should be understood that the above specific embodiments of the present invention are only used to illustrate or explain the principles of the present invention, and do not constitute a limitation of the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. In addition, the appended claims of the present invention are intended to cover all changes and modifications that fall within the scope and boundaries of the appended claims, or the equivalent forms of such scope and boundaries.

Claims

1. A plasma activated gas wound treatment device, characterized in that: include: A plasma generator (300), a treatment chamber (400), a high voltage power supply module (200), an air pump (100) and a control module (700), wherein: The treatment chamber (400) comprises an air supply passage (410) and an air return passage (420); the air return passage (420) is connected to an air inlet of the plasma generator (300) through an air pump (100); the air supply passage (410) is connected to an air outlet of the plasma generator (300); and both the plasma generator (300) and the air pump (100) are arranged outside the treatment chamber (400); The high-voltage power supply module (200) is electrically connected to the plasma generator (300) and the control module (700) respectively, and the control module (700) controls the on and off of the high-voltage power supply module (200) to thereby control the plasma generator (300) to be in an intermittent working state or a continuous working state; The plasma generator (300) generates a first type of plasma activated gas in an intermittent working state, wherein the first type of plasma activated gas includes O3 and N2O5, and is used to disinfect the part to be treated in the treatment chamber (400); The plasma generator (300) generates a second type of plasma activated gas in a continuous working state, wherein the second type of plasma activated gas includes NO and is used to promote the healing of the part to be treated in the treatment chamber (400).

2. The plasma activated gas wound treatment device according to claim 1, characterized in that: The intermittent working state comprises: in a first time period, discharge and flow of working gas are simultaneously performed in the plasma generator (300); in a second time period, the flow of working gas in the plasma generator (300) stops discharge, and the first time period and the second time period are sequentially connected and circulated.

3. The plasma activated gas wound treatment device according to claim 1, characterized in that: The continuous working state includes: discharge and flow of working gas simultaneously in the plasma generator (300).

4. The plasma activated gas wound treatment device according to claim 1, characterized in that: The wound treatment device further comprises a temperature regulating module (500) and a flow rate regulating module (600), and the control module (700) is electrically connected to the temperature regulating module (500) and the flow rate regulating module (600), respectively.

5. The plasma activated gas wound treatment device according to claim 4, characterized in that: The temperature regulating module (500) comprises a refrigeration device and a heating device. When the plasma generator (300) switches from an intermittent working state to a continuous working state, the control module (700) starts the heating device to heat the environment around the plasma generator (300); when the plasma generator (300) switches from a continuous working state to an intermittent working state, the control module (700) starts the refrigeration device to cool the environment around the plasma generator (300).

6. The plasma activated gas wound treatment device according to claim 4, characterized in that: When the plasma generator (300) switches from an intermittent working state to a continuous working state, the control module (700) controls the flow rate regulating module (600) to reduce the flow rate of the air pump (100); and when the plasma generator (300) switches from a continuous working state to an intermittent working state, the control module (700) controls the flow rate regulating module (600) to increase the flow rate of the air pump (100).

7. The plasma activated gas wound treatment device according to claim 1, characterized in that: The treatment chamber (400) further includes a three-way valve (450), and the three-way valve (450) is arranged between the return air passage (420) and the air pump (100).

8. The plasma activated gas wound treatment device according to claim 7, characterized in that: The three-way valve (450) is provided with a suspended end, and the suspended end adjusts the gas pressure in the treatment chamber (400) by introducing working gas outside the treatment chamber (400), including: During the treatment process, the plasma generator (300) is turned on, the suspended end is turned on, and the gas pump (100) inhales the working gas while recovering the plasma activated gas. The treatment process includes an intermittent working state and a continuous working state of the plasma generator (300); When the treatment is finished, the plasma generator (300) is turned off, the suspended end is closed, and the gas pump (100) only recycles the plasma activated gas.

9. The plasma activated gas wound treatment device according to claim 1, characterized in that: The total content of O3 and N2O5 accounts for more than 55% of the total concentration of active substances in the first type of plasma activated gas, and the content of NO accounts for more than 35% of the total concentration of active substances in the second type of plasma activated gas.

10. A method for treating a wound using the plasma activated gas wound treatment device according to any one of claims 1 to 9, characterized in that: The method comprises: The plasma generator (300) is set to an intermittent working state, and the suspended end of the three-way valve (450) is opened to generate a first type of plasma activated gas, the first type of plasma activated gas is input into the treatment chamber (400) through the gas supply passage (410) to disinfect the treatment site, and the plasma activated gas is recovered through the gas return passage (420), the intermittent working state operation time is 0-30 minutes, wherein the first type of plasma activated gas includes O3 and N2O5; After the intermittent working state is finished, the plasma generator (300) is controlled to switch to the continuous working state, the suspended end of the three-way valve (450) is opened to generate a second type of plasma activated gas, the second type of plasma activated gas is input into the treatment chamber (400) through the gas supply passage (410) to promote the healing of the treated part, and the plasma activated gas is recovered through the gas return passage (420), the continuous working state running time is 0-30 minutes, wherein the second type of plasma activated gas includes NO; After the continuous working state is finished, the suspended end of the three-way valve (450) is closed, the plasma generator (300) is turned off, and the treatment is finished.

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