Traditional Chinese medicine massage cream with rapid drug release capability and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine massage cream with rapid drug release capability and a preparation method thereof. The traditional Chinese medicine massage cream comprises a traditional Chinese medicine extract and a matrix, the matrix comprises modified sodium polyacrylate, a thickening agent, a humectant, cetostearyl alcohol and deionized water; the modified sodium polyacrylate is prepared by copolymerizing acrylic acid, acrylamide and cationic lignin; the cationic lignin is prepared from alkali lignin, epoxy chloropropane and 3-chloro-2-hydroxypropyl trimethyl ammonium chloride through a reaction. The medicine carrying capacity and the medicine releasing capacity of a matrix can be effectively improved, the infiltration effect of the massage cream can be improved, and then the absorption effect of a human body on traditional Chinese medicine ingredients in the massage process is promoted; meanwhile, the compounded traditional Chinese medicine components can effectively relieve diseases such as rheumatoid arthritis, scapulohumeral periarthritis, bone tuberculosis, cervical vertebra pain, lumbar disc herniation and limb pain and numbness, and can be widely applied to the field of traditional Chinese medicine massage ointment.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine massage cream with rapid drug release capability and a preparation method thereof. Background Art

[0002] Soft tissue injury refers to pathological damage to human skin, superficial and deep fascia under the skin, tendons, tendon sheaths, ligaments, joint capsules, synovial capsules, intervertebral discs, peripheral nerves and blood vessels caused by various acute trauma or chronic strain, as well as invasion of wind, cold and dampness. Clinical manifestations include local pain, swelling, numbness, tenderness, limb function or activity disorders, etc. Soft tissue injury is a common disease, and its incidence rate is second only to colds.

[0003] Clinically, Western medicine mainly uses anti-inflammatory drugs for analgesia. Commonly used anti-inflammatory drugs include non-steroidal anti-inflammatory drugs, corticosteroids, synthetic steroids, etc. However, these drugs have relatively large toxic side effects. Long-term use can cause damage to the gastrointestinal tract, nerves, liver and kidneys.

[0004] Traditional Chinese medicine mainly uses traditional massage techniques and plasters to treat soft tissue injuries. Massage therapy is the oldest physical therapy for the purpose of curing diseases. In addition to treating surgical diseases (i.e. trauma massage), it can also treat internal diseases (gynecology, internal medicine, pediatrics, etc.), and has a very good effect on chronic diseases, functional diseases, and developmental diseases. Massage, also known as Tuina therapy, is one of the treatment methods of traditional Chinese medicine. It usually refers to the doctor using his own hands to act on the patient's body surface, injured parts, uncomfortable places, specific acupoints, and painful places. Specifically, various techniques such as pushing, holding, pressing, rubbing, kneading, pinching, tapping, and patting are used to achieve the effect of dredging meridians, promoting qi and blood, healing injuries and relieving pain, removing evil and strengthening the body, and harmonizing yin and yang.

[0005] In order to enhance the therapeutic effect and prevent skin damage, massage cream (oil) is usually used as a lubricating medium during massage. Massage cream is a type of ointment specially used in conjunction with massage. It is widely used in traumatology, orthopedics, ENT, dermatology and beauty. It is absorbed through the skin to produce medicinal effects. It can enter the skin through the release and penetration of drugs to achieve local therapeutic effects.

[0006] However, the massage cream in the prior art has limited drug-carrying and drug-releasing capacity for traditional Chinese medicine, and cannot give full play to the body's absorption capacity of traditional Chinese medicine during massage, resulting in the loss of a large amount of effective ingredients.

[0007] Therefore, there is an urgent need for a Chinese medicine massage cream that has excellent drug loading and release capabilities and can promote human absorption. Summary of the invention

[0008] Purpose of the invention: In view of the defects of the prior art, the purpose of the present invention is to provide a Chinese medicine massage cream with excellent drug loading and release capacity and rapid drug release ability that can promote human absorption and a preparation method thereof.

[0009] Technical solution:

[0010] A Chinese medicine massage cream with rapid drug release capability, comprising a Chinese medicine extract and a matrix;

[0011] The matrix includes modified sodium polyacrylate, a thickener, a moisturizer, cetearyl alcohol and deionized water;

[0012] The modified sodium polyacrylate is prepared by copolymerization of acrylic acid, acrylamide and cationic lignin;

[0013] The cationic lignin is prepared by reacting alkali lignin, epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride.

[0014] Furthermore, the modified sodium polyacrylate is prepared by the following steps: adding acrylic acid, acrylamide, cationic lignin and deionized water into a reactor, heating to 40-50°C and stirring to dissolve, adding an initiator and heating to 80-90°C, reacting for 6-8 hours, cooling, filtering and washing to obtain the modified sodium polyacrylate.

[0015] The present invention adds modified sodium polyacrylate to the matrix, and based on the cross-linked network structure of sodium polyacrylate, the Chinese medicine extract can be effectively adsorbed, and its porous and rapidly swellable structure can significantly improve the drug-carrying capacity of the matrix for the Chinese medicine extract, and stably store the Chinese medicine extract under the coating of oil, and release the adsorbed Chinese medicine extract after the oil is broken in the subsequent massage process.

[0016] Furthermore, the initiator is selected from one of ammonium persulfate, potassium persulfate or sodium persulfate; the mass ratio of acrylic acid, acrylamide and cationic lignin is (13-15): (4-6): (7-8);.

[0017] Furthermore, the cationic lignin is prepared by the following steps: adding alkali lignin and sodium hydroxide aqueous solution into a reactor, stirring and dissolving, heating to 70-80°C, adding epichlorohydrin, refluxing for 3-4 hours, adding 3-chloro-2-hydroxypropyltrimethylammonium chloride, heating to 90-95°C, refluxing for 6-8 hours, cooling, filtering, washing and drying to obtain the cationic lignin.

[0018] In the present invention, cationic lignin is grafted onto sodium polyacrylate. On the one hand, lignin, as a natural high molecular compound with a three-dimensional spatial structure, has excellent compatibility and stability for Chinese herbal medicine extracts, and can further improve the drug-carrying capacity of the matrix for the Chinese herbal medicine extracts. On the other hand, lignin has a certain dispersion ability, and can assist in the dispersion of the massage cream on the skin surface during the massage process, and promote the release of the Chinese herbal medicine extracts, thereby improving the drug release capacity of the massage cream.

[0019] Furthermore, the mass ratio of the alkali lignin, epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride is (15-20):(2-3):(4-5); and the mass concentration of the sodium hydroxide aqueous solution is 10-15wt%.

[0020] The present invention modifies alkali lignin by using epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride, so that a cationic quaternary ammonium structure is grafted onto the surface of the alkali lignin. On the one hand, the cationic quaternary ammonium structure has a certain pore-forming effect, which can further enlarge the pore size and quantity of the lignin and improve the drug-carrying capacity of the matrix for the Chinese medicine extract. On the other hand, the cationic quaternary ammonium structure has excellent surface activity, which can further improve the release rate of the matrix for the Chinese medicine extract during the massage process and improve the drug release capacity of the massage cream. In addition, a trace amount of the quaternary ammonium salt structure can improve the absorption effect of the skin pores and promote the absorption effect of the Chinese medicine extract by the human body.

[0021] Furthermore, the thickener is selected from one of xanthan gum and carbomer; and the humectant is selected from one of glycerin, butylene glycol and propylene glycol.

[0022] Furthermore, based on the total mass fraction being 100, the mass percentage of each component in the matrix is:

[0023]

[0024] The balance was deionized water.

[0025] Furthermore, the Chinese medicine extract is made from the following raw materials in parts by weight: 6-8 parts of angelica, 3-4 parts of safflower, 4-6 parts of cassia twig, 3-4 parts of radix polygoni lobatae, 3-4 parts of mulberry twig, 2-3 parts of myrrh, 1-2 parts of frankincense and 4-5 parts of turmeric.

[0026] Furthermore, the mass ratio of the traditional Chinese medicine extract to the matrix is ​​1:1.5-2.5.

[0027] The method for preparing any one of the above-mentioned Chinese medicine massage creams comprises the following steps:

[0028] (1) In a reactor, angelica, safflower, cinnamon twig, herba scutellariae, mulberry twig, myrrh, frankincense and turmeric are added in proportion, ground and crushed, extracted with 15-60% ethanol solution, filtered, and concentrated to a relative density of 1.05-1.10 to obtain a Chinese medicine extract;

[0029] (2) In a reactor, add modified sodium polyacrylate, a thickener, a moisturizer, cetearyl alcohol and deionized water, heat to 40-50°C, stir evenly, then raise the temperature to 55-60°C, slowly add the Chinese medicine extract obtained in step (1) under stirring conditions of 200-250 rpm, stir until the solution becomes viscous, and then cool to obtain the Chinese medicine massage cream.

[0030] Beneficial effects:

[0031] (1) The Chinese medicine massage cream with rapid drug release provided by the present invention can effectively improve the drug loading capacity and drug release capacity of the matrix by adding modified sodium polyacrylate and supplemented with thickener, moisturizer and cetearyl alcohol in the matrix, and can also improve the infiltration effect of the massage cream, thereby promoting the absorption effect of the Chinese medicine ingredients by the human body during the massage process. At the same time, the compounded Chinese medicine ingredients can effectively relieve rheumatoid arthritis, scapulohumeral periarthritis, bone tuberculosis, cervical pain, lumbar disc herniation, and limb pain and numbness, and can be widely used in the field of Chinese medicine massage cream.

[0032] (2) The Chinese medicine massage cream with rapid drug release provided by the present invention has modified sodium polyacrylate added to the matrix. The cross-linked network structure of sodium polyacrylate can effectively adsorb the Chinese medicine extract, and its porous and rapidly swellable structure can significantly improve the drug loading capacity of the matrix for the Chinese medicine extract, and stably store the Chinese medicine extract under the coating of oil. After the oil breaks down during the subsequent massage process, the adsorbed Chinese medicine extract is released.

[0033] (3) The Chinese medicine massage cream with rapid drug release provided by the present invention comprises cationic lignin grafted onto sodium polyacrylate. On the one hand, lignin, as a natural polymer compound with a three-dimensional spatial structure, has excellent compatibility and stability with Chinese medicine extracts, and can further improve the drug-carrying capacity of the matrix for Chinese medicine extracts. On the other hand, lignin has a certain dispersion ability, and can assist in the dispersion of the massage cream on the skin surface during the massage process, and promote the release of the Chinese medicine extract, thereby improving the drug release capacity of the massage cream.

[0034] (4) The Chinese medicine massage cream with rapid drug release provided by the present invention is modified by epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride to graft a cationic quaternary ammonium structure on its surface. On the one hand, the cationic quaternary ammonium structure has a certain pore-forming effect, which can further expand the pore size and number of lignin and improve the drug-carrying capacity of the matrix for Chinese medicine extracts; on the other hand, the cationic quaternary ammonium structure has excellent surface activity, which can further increase the release rate of the matrix for Chinese medicine extracts during massage and improve the drug release capacity of the massage cream. In addition, a trace amount of quaternary ammonium salt structure can increase the absorption effect of skin pores and promote the absorption effect of Chinese medicine extracts by the human body. DETAILED DESCRIPTION

[0035] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0036] Sodium polyacrylate and alkali lignin were purchased from Aladdin Reagents; the remaining reagents and equipment were conventional reagents and equipment in the technical field.

[0037] Preparation of cationic lignin

[0038] Cationic lignin was prepared by the following steps:

[0039] In a reactor, 1.5 g of alkali lignin and 100 mL of a 15 wt% sodium hydroxide aqueous solution were added, stirred and dissolved, and then heated to 75° C., 0.2 g of epichlorohydrin was added and refluxed for 3 hours, and then 0.5 g of 3-chloro-2-hydroxypropyltrimethylammonium chloride was added, and the temperature was raised to 90° C. and refluxed for 8 hours, and then cooled, filtered, washed, and dried to obtain the cationic lignin.

[0040] Preparation of Modified Sodium Polyacrylate-1

[0041] Modified sodium polyacrylate-1 was prepared by the following steps:

[0042] In a reactor, 1.5 g of acrylic acid, 0.5 g of acrylamide, 0.8 g of cationic lignin and 100 mL of deionized water were added, heated to 40° C. and stirred to dissolve, then 0.1 g of ammonium persulfate was added and the temperature was raised to 90° C. After reacting for 8 hours, the modified sodium polyacrylate-1 was obtained after cooling, filtering and washing.

[0043] Preparation of Modified Sodium Polyacrylate-2

[0044] The preparation method is basically the same as modified sodium polyacrylate-1, except that the cationic lignin is replaced by an equal amount of alkali lignin.

[0045] Example 1

[0046] The Chinese medicine massage ointment with rapid drug release capability is prepared by the following steps:

[0047] (1) In a reactor, angelica, safflower, cinnamon twig, herba scutellariae, mulberry twig, myrrh, frankincense and turmeric are added in proportion, ground and crushed, extracted with 45% ethanol solution, filtered and concentrated to a relative density of 1.10 to obtain a traditional Chinese medicine extract;

[0048] (2) Add modified sodium polyacrylate-1, xanthan gum, glycerin, cetearyl alcohol and deionized water to a reactor, heat to 50° C., stir evenly, then heat to 60° C., slowly add the Chinese medicine extract obtained in step (1) under stirring at 250 rpm, stir until the solution becomes viscous, and then cool to obtain the Chinese medicine massage cream;

[0049] The Chinese medicine extract is prepared from the following raw materials in parts by weight: 8 parts of angelica, 3 parts of safflower, 5 parts of cassia twig, 3 parts of radix spatholobi, 4 parts of mulberry twig, 2 parts of myrrh, 1 part of frankincense and 5 parts of turmeric;

[0050] Taking the total mass fraction as 100, the mass percentage of each component in the matrix is:

[0051]

[0052] The balance was deionized water.

[0053] The mass ratio of the traditional Chinese medicine extract to the matrix is ​​1:2.

[0054] Example 2

[0055] Basically the same as Example 1, except that the mass percentage of each component in the matrix is ​​calculated based on the total mass fraction as 100:

[0056]

[0057] The balance is deionized water;

[0058] The mass ratio of the traditional Chinese medicine extract to the matrix was changed to 1:1.5.

[0059] Example 3

[0060] Basically the same as Example 1, except that the mass percentage of each component in the matrix is ​​calculated based on the total mass fraction as 100:

[0061]

[0062] The balance is deionized water;

[0063] The mass ratio of the traditional Chinese medicine extract to the matrix was changed to 1:2.5.

[0064] Comparative Example 1

[0065] The method is basically the same as Example 1, except that the modified sodium polyacrylate-1 is replaced by an equal amount of cetearyl alcohol.

[0066] Comparative Example 2

[0067] The method is basically the same as Example 1, except that the modified sodium polyacrylate-1 is replaced by an equal amount of sodium polyacrylate.

[0068] Comparative Example 3

[0069] The method is basically the same as Example 1, except that the modified sodium polyacrylate-1 is replaced by an equal amount of modified sodium polyacrylate-2.

[0070] Performance Testing

[0071] 50 patients were treated with the products of Examples 1-3 and Comparative Examples 1-3, respectively, and the treated disease was rheumatoid arthritis. The treatment method was: the affected area was massaged with the products of Examples 1-3 and Comparative Examples 1-3, the affected area was disinfected with 75% alcohol before treatment, and then a hot towel was used to apply heat to the patient for 5-10 minutes, and then an appropriate amount of the product was taken to massage the affected area for 10-15 minutes, 3-4 times a week, and the treatment time was 3 months. During the treatment, depending on the patient's recovery, the treatment can be stopped when the patient reaches the cure standard.

[0072] The number of cases that were cured, improved, and ineffective was recorded. The results are shown in the following table:

[0073]

[0074]

[0075] According to the test results of Examples 1-3, the Chinese medicine massage cream with rapid drug release provided by the present invention has excellent therapeutic effects, can effectively alleviate symptoms such as rheumatoid arthritis, and can be widely used in the field of Chinese medicine massage cream.

[0076] According to the comparison of the test results of Examples 1-3 and Comparative Examples 1-3, it can be seen that by adding modified sodium polyacrylate to the Chinese medicine massage cream with rapid drug release ability provided by the present invention, the drug loading capacity and drug release capacity of the matrix can be effectively improved, and the human body's absorption effect of the drug can be improved, thereby significantly improving the therapeutic effect of the Chinese medicine massage cream.

[0077] The above implementation modes are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine massage cream with rapid drug release capability, characterized in that: Including Chinese herbal medicine extracts and matrices; The matrix includes modified sodium polyacrylate, a thickener, a moisturizer, cetearyl alcohol and deionized water; The modified sodium polyacrylate is prepared by copolymerization of acrylic acid, acrylamide and cationic lignin; The cationic lignin is prepared by reacting alkali lignin, epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride.

2. The Chinese medicine massage cream with rapid drug release capability according to claim 1, characterized in that: The modified sodium polyacrylate is prepared by the following steps: adding acrylic acid, acrylamide, cationic lignin and deionized water into a reactor, heating to 40-50° C. and stirring to dissolve, adding an initiator and heating to 80-90° C., reacting for 6-8 hours, cooling, filtering and washing to obtain the modified sodium polyacrylate.

3. The Chinese medicine massage cream with rapid drug release capability according to claim 2, characterized in that: The initiator is selected from one of ammonium persulfate, potassium persulfate or sodium persulfate; the mass ratio of acrylic acid, acrylamide and cationic lignin is (13-15): (4-6): (7-8).

4. The Chinese medicine massage cream with rapid drug release capability according to claim 2, characterized in that: The cationic lignin is prepared by the following steps: adding alkali lignin and sodium hydroxide aqueous solution into a reactor, stirring and dissolving, heating to 70-80° C., adding epichlorohydrin, refluxing for 3-4 hours, adding 3-chloro-2-hydroxypropyltrimethylammonium chloride, heating to 90-95° C., refluxing for 6-8 hours, cooling, filtering, washing and drying to obtain the cationic lignin.

5. The Chinese medicine massage cream with rapid drug release capability according to claim 4, characterized in that: The mass ratio of the alkali lignin, epichlorohydrin and 3-chloro-2-hydroxypropyltrimethylammonium chloride is (15-20):(2-3):(4-5); and the mass concentration of the sodium hydroxide aqueous solution is 10-15wt%.

6. The Chinese medicine massage cream with rapid drug release capability according to claim 1, characterized in that: The thickener is selected from one of xanthan gum and carbomer; the moisturizer is selected from one of glycerin, butylene glycol and propylene glycol.

7. The Chinese medicine massage cream with rapid drug release capability according to claim 1, characterized in that: Taking the total mass fraction as 100, the mass percentage of each component in the matrix is: The balance was deionized water.

8. The Chinese medicine massage cream with rapid drug release capability according to claim 1, characterized in that: The Chinese medicine extract is prepared from the following raw materials in parts by weight: 6-8 parts of angelica sinensis, 3-4 parts of safflower, 4-6 parts of cassia twig, 3-4 parts of radix spatholobi, 3-4 parts of mulberry twig, 2-3 parts of myrrh, 1-2 parts of frankincense and 4-5 parts of turmeric.

9. The Chinese medicine massage cream with rapid drug release capability according to claim 1, characterized in that: The mass ratio of the traditional Chinese medicine extract to the matrix is ​​1:1.5-2.

5.

10. The method for preparing the Chinese medicine massage cream according to any one of claims 1 to 9, characterized in that: The following steps are involved: (1) In a reactor, angelica, safflower, cinnamon twig, herba scutellariae, mulberry twig, myrrh, frankincense and turmeric are added in proportion, ground and crushed, extracted with 15-60% ethanol solution, filtered, and concentrated to a relative density of 1.05-1.10 to obtain a Chinese medicine extract; (2) In a reactor, add modified sodium polyacrylate, a thickener, a moisturizer, cetearyl alcohol and deionized water, heat to 40-50°C, stir evenly, then raise the temperature to 55-60°C, slowly add the Chinese medicine extract obtained in step (1) under stirring conditions of 200-250 rpm, stir until the solution becomes viscous, and then cool to obtain the Chinese medicine massage cream.

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