Traditional Chinese medicine composition for treating diabetes

Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes mellitus, which belongs to the technical field of traditional Chinese medicines and mainly comprises rhizoma anemarrhenae, broussonetia papyrifera leaves, salvia miltiorrhiza, raw leech powder, gypsum powder, sodium alginate powder and water. The rhizoma anemarrhenae, the broussonetia papyrifera leaves and the radix salviae miltiorrhizae used in the traditional Chinese medicine composition provided by the invention can effectively treat diabetes mellitus through a synergistic effect after reasonable compatibility, and the traditional Chinese medicine composition is remarkable in effect, simple in preparation process and low in cost.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating diabetes. Background Art

[0002] Diabetes is a metabolic disease characterized by high blood sugar caused by absolute or relative insufficient secretion of insulin and impaired utilization. The disease is mainly divided into three types: type 1, type 2 and gestational diabetes. The cause is mainly attributed to the combined effects of genetic and environmental factors, including decreased insulin secretion caused by islet cell dysfunction, or the body's insensitivity to insulin, or both, which prevents glucose in the blood from being effectively utilized and stored. Some diabetic patients and families have a clustering phenomenon of the disease. Patients with a long course of diabetes may develop chronic progressive lesions, functional impairment or even failure of tissues and organs such as the eyes, kidneys, nerves, heart, and blood vessels, and may cause acute and severe metabolic disorders. In addition, the incidence and prevalence of diabetes are on the rise nationwide and even globally.

[0003] Anemarrhena, rhizome horizontal, the whole plant is hairless; leaves are clustered at the base, in the shape of grass leaves; racemes, flower stems erect, perianth segments strip-shaped, pink, lavender to white; capsule six-angled long ovoid, seeds black. "Compendium of Materia Medica" records that Anemarrhena is bitter in nature and cold; enters the lung, stomach, and kidney meridians, and has the effects of clearing heat and purging fire, nourishing yin and moistening dryness.

[0004] Paper mulberry leaf, also known as paper mulberry leaf or mulberry leaf, is the leaf of the deciduous tree paper mulberry of the Moraceae family. It is sweet, cool in nature, and non-toxic. It contains chemical components such as flavonoids, phenols, organic acids, and tannins. It has the effects of cooling blood and promoting diuresis.

[0005] Danshen, the root of which is used as medicine, contains tanshinone, which is a strong and emmenagogue, with the effects of removing blood stasis, promoting new blood, activating blood circulation, and regulating menstruation. It is an important gynecological medicine, mainly used to treat uterine bleeding, irregular menstruation, blood stasis, abdominal pain, dysmenorrhea, amenorrhea, and hernia pain. It has a good effect on the treatment of coronary heart disease.

[0006] Anemarrhena asphodeloides, Broussonetia scoparia and Salvia miltiorrhiza each have their own unique pharmacological effects in the field of traditional Chinese medicine, but there are currently few studies and applications on their combination for the treatment of diabetes. Summary of the invention

[0007] The invention provides a traditional Chinese medicine composition for treating diabetes. The formula of the traditional Chinese medicine composition mainly consists of rhizoma anemarrhenae, rhizoma pyrifera leaves, salvia miltiorrhiza, raw leech powder, gypsum powder, sodium alginate powder and water. The rhizoma anemarrhenae, rhizoma pyrifera leaves and salvia miltiorrhiza can effectively treat diabetes through synergistic effect after reasonable compatibility.

[0008] In order to achieve the purpose of the present invention, the technical solution of the present invention is as follows:

[0009] A traditional Chinese medicine composition for treating hypertension is prepared from the following raw materials in parts by weight: 3-20 parts of rhizoma anemarrhenae, 5-20 parts of paper mulberry leaves, 3-20 parts of salvia miltiorrhiza, 2 parts of raw leech powder, 5 parts of raw gypsum powder, 5 parts of sodium alginate powder and 300 parts of water.

[0010] Furthermore, the preparation method comprises the following steps:

[0011] S1: Weighing Rhizoma Anemarrhenae, Rhizoma Broussonetiae and Salvia miltiorrhizae according to the required weight proportions of each raw material, and respectively preparing powders of Rhizoma Anemarrhenae, Rhizoma Broussonetiae and Salvia miltiorrhizae by roasting, crushing, grinding and sieving;

[0012] S2: weighing raw leech powder and raw gypsum powder according to the required weight proportions of each raw material, sieving them to obtain raw leech powder and raw gypsum powder;

[0013] S3: weighing sodium alginate powder and the Anemarrhena asphodeloides, Broussonetia papyrifera leaves, Salvia miltiorrhiza powder and Gypsum foetida powder obtained in S1 and S2 according to the required weight proportions of each raw material, adding water and boiling; after cooling, adding raw leech powder and mixing evenly to obtain a Chinese medicine composition.

[0014] Furthermore, the sieving in S1 and S2 uses a sieve of 80-120 mesh.

[0015] Furthermore, when S3 is added with water for decocting, it is boiled and then simmered over low heat for 50-70 minutes.

[0016] Furthermore, the Chinese medicine composition described in the present invention is a decoction.

[0017] Compared with the prior art, the beneficial effects of the present invention are mainly reflected in that the Chinese medicine composition provided by the present invention can treat diabetes through the synergistic effect of Anemarrhena asphodeloides, Broussonetia scoparia and Salvia miltiorrhiza after reasonable compatibility, and has significant effect, simple preparation process and low cost. DETAILED DESCRIPTION

[0018] The present method is further described below in conjunction with specific embodiments, but the following content should not be interpreted as limiting the scope of protection of the invention to any extent.

[0019] Example 1

[0020] Weigh 4 grams of Anemarrhena asphodeloides, 6 grams of Broussonetia mulberry leaves, 18 grams of Salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of gypsum powder, 5 grams of sodium alginate powder and 300 grams of water; bake the Anemarrhena asphodeloides, Broussonetia mulberry leaves and Salvia miltiorrhiza at 70°C, crush, grind and pass through a 100-mesh sieve; pass the raw leech powder and gypsum powder through a 100-mesh sieve; add the sodium alginate powder and the obtained powders of Anemarrhena asphodeloides, Broussonetia mulberry leaves, Salvia miltiorrhiza and gypsum powder into water and boil for 60 minutes; after cooling, add the raw leech powder and mix well to obtain a traditional Chinese medicine composition.

[0021] Example 2

[0022] Weigh 4 grams of Anemarrhena asphodeloides, 18 grams of Broussonetia papyrifera leaves, 6 grams of Salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder, and 300 grams of water to prepare a Chinese medicine composition. The preparation method is the same as that in Example 1.

[0023] Example 3

[0024] Weigh 8 grams of Anemarrhena asphodeloides, 12 grams of Broussonetia papyrifera leaves, 8 grams of Salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder, and 300 grams of water to prepare a Chinese medicine composition. The preparation method is the same as that in Example 1.

[0025] Example 4

[0026] Weigh 18 grams of Anemarrhena asphodeloides, 6 grams of Broussonetia papyrifera leaves, 4 grams of Salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder, and 300 grams of water to prepare a Chinese medicine composition. The preparation method is the same as that in Example 1.

[0027] Comparative Example 1

[0028] Weigh 28 grams of Anemarrhena asphodeloides, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder and 300 grams of water; bake the Anemarrhena asphodeloides at 70°C, crush, grind and pass through a 100-mesh sieve; pass the raw leech powder and raw gypsum powder through a 100-mesh sieve; add the sodium alginate powder and the obtained powders of Anemarrhena asphodeloides and raw gypsum powder into water and boil for 60 minutes; after cooling, add the raw leech powder and mix well to obtain a traditional Chinese medicine composition.

[0029] Comparative Example 2

[0030] Weigh 28 grams of paper mulberry leaves, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder and 300 grams of water; bake the paper mulberry leaves at 70°C, crush, grind and pass through a 100-mesh sieve; pass the raw leech powder and raw gypsum powder through a 100-mesh sieve; add the sodium alginate powder and the obtained paper mulberry leaves and raw gypsum powder into water and boil for 60 minutes; after cooling, add the raw leech powder and mix well to obtain a traditional Chinese medicine composition.

[0031] Comparative Example 3

[0032] Weigh 28 grams of salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of raw gypsum powder, 5 grams of sodium alginate powder and 300 grams of water; bake the salvia miltiorrhiza at 70°C, crush, grind and pass through a 100-mesh sieve; pass the raw leech powder and raw gypsum powder through a 100-mesh sieve; add the sodium alginate powder and the obtained powders of salvia miltiorrhiza and raw gypsum powder into water and boil for 60 minutes; after cooling, add the raw leech powder and mix well to obtain a traditional Chinese medicine composition.

[0033] Drug trials

[0034] The following experiments further verify the efficacy of the Chinese medicine composition of the present invention on diabetes, and the use of a mixture of anemarrhena, mulberry leaves, and salvia miltiorrhiza powder with raw leech powder, gypsum powder, sodium alginate powder, and water in the present invention can have a better therapeutic effect for treating diabetes through a synergistic effect compared to a mixture of anemarrhena, mulberry leaves, and salvia miltiorrhiza powder alone with raw leech powder, gypsum powder, sodium alginate powder, and water.

[0035] 80 SPF KM mice were prepared, 8 weeks old, and randomly divided into 8 groups, namely, a blank control group, Example 1-4 groups, and Comparative Example 1-3 groups. After being fed with a high-calorie diet for 1 month, 30 mg / kg body weight of streptozotocin was intraperitoneally injected for 2 to 4 consecutive days; blood was collected from the tip of the tail to detect the fasting blood glucose value and record it. After recording the initial blood glucose value, the Chinese medicine composition decoction prepared by the Example group and the Comparative Example group of the present invention was gavaged to the mice at a dosage of 5 ml per day from the first week, and the blank control group was gavaged with an equal volume of distilled water, twice a day, for five consecutive weeks. During this period, the fasting blood glucose value of the mice was measured every day, and the mean blood glucose value of each group of mice for five weeks was counted, and the results are shown in the following table.

[0036]

[0037] It can be seen from the above test results that the mixed Chinese medicine composition of Anemarrhena asphodeloides, Broussonetia mulberry leaves, Salvia miltiorrhiza, raw leech powder, gypsum powder, sodium alginate powder and water in Examples 1-4 is more effective in treating diabetes than the Chinese medicine composition of Anemarrhena asphodeloides, Broussonetia mulberry leaves, Salvia miltiorrhiza, raw leech powder, gypsum powder, sodium alginate powder and water used alone in Comparative Examples 1-3, wherein the therapeutic effect of the Chinese medicine composition prepared with 8 grams of Anemarrhena asphodeloides, 12 grams of Broussonetia mulberry leaves, 8 grams of Salvia miltiorrhiza, 2 grams of raw leech powder, 5 grams of gypsum powder, 5 grams of sodium alginate powder and 300 grams of water as raw materials is the best; the Chinese medicine composition of Anemarrhena asphodeloides, Broussonetia mulberry leaves, Salvia miltiorrhiza, raw leech powder, gypsum powder, sodium alginate powder and water used alone in the comparative example is effective but not significant compared with the blank control group.

[0038] Performance Testing

[0039] Patient analysis: A total of 70 diabetic patients were selected, including 35 males and 35 females, aged between 45 and 66 years old.

[0040] The patients were divided into 7 groups and treated with the Chinese medicine compositions prepared in Examples 1-4 and Comparative Examples 1-3, respectively. The treatment was carried out by taking 200 ml each time, 3 times a day, 1 hour before meals, for a course of 10 days. The efficacy was evaluated according to the "Standards for Diagnosis and Efficacy of Chinese Medicine Diseases". The results are shown in the following table:

[0041] Improvement / person Invalid / person Example 1 Group 7 3 Example 2 Group 7 3 Example 3 Group 8 2 Example 4 Group 7 3 Comparative Example 1 2 8 Comparative Example 2 2 8 Comparative Example 3 1 9

[0042] In summary, among the raw materials of the Chinese medicine composition of the present invention, using Anemarrhena asphodeloides, Broussonetia scoparia and Salvia miltiorrhiza together can enhance the effect of treating diabetes through a synergistic effect, can more effectively treat diabetes, and has better effects than using them alone.

[0043] The above only lists the preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any changes made by those skilled in the art within the scope of the claims of the present invention shall fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating diabetes, characterized in that: The composition is prepared from the following raw materials in parts by weight: 3-20 parts of rhizoma anemarrhenae, 5-20 parts of paper mulberry leaves, 3-20 parts of salvia miltiorrhiza, 2 parts of raw leech powder, 5 parts of raw gypsum powder, 5 parts of sodium alginate powder and 300 parts of water.

2. A Chinese medicine composition for treating diabetes as claimed in claim 1, characterized in that: The preparation method of the composition comprises the following steps: S1: Weigh the weight proportions of the raw materials according to claim 1, and prepare the powders of Anemarrhena asphodeloides, Broussonetia melanocarpa and Salvia miltiorrhiza respectively by roasting, crushing, grinding and sieving; S2: weighing raw leech powder and raw gypsum powder according to the weight proportions of the raw materials described in claim 1, and sieving them to obtain raw leech powder and raw gypsum powder; S3: according to the weight proportions of the raw materials described in claim 1, weigh sodium alginate powder and the Anemarrhena asphodeloides, Broussonetia papyrifera, Salvia miltiorrhiza powder and Gypsum foetida powder obtained in S1 and S2, add water and boil; after cooling, add raw leech powder and mix well to obtain a Chinese medicine composition.

3. The method for preparing a Chinese medicine composition for treating diabetes according to claim 2, characterized in that: The sieving in S1 and S2 uses a 80-120 mesh sieve.

4. The method for preparing a Chinese medicine composition for treating diabetes as claimed in claim 2, characterized in that: When S3 is added to water and boiled, turn to low heat and simmer for 50-70 minutes.

5. The method for preparing a Chinese medicine composition for treating diabetes as claimed in claim 2, characterized in that: The Chinese medicine composition is a decoction.

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