Fermentation tank

Abstract

The invention relates to a fermentation tank which comprises a tank body and a stirring device, and the stirring device comprises a stirring shaft arranged in the tank body; the rotary starter is connected with the stirring shaft and drives the stirring shaft to rotate in a fixed-axis manner; the stirring blade is arranged on the stirring shaft, more than two through holes are formed in the stirring blade, each through hole is provided with a liquid facing surface and a liquid outlet surface, and the area of the liquid facing surface is larger than or equal to that of the liquid outlet surface. The fermentation tank disclosed by the invention not only facilitates fermentation conversion reaction of microorganisms and improves the mixing and reaction efficiency, but also can effectively save the replacement cost of the device and reduce the energy consumption.

Description

Technical Field

[0001] The invention relates to a fermentation tank and belongs to the field of microbial industry. Background Art

[0002] Compared with the traditional chemical synthesis industry, the reaction objects in the microbial industry are usually more complex. For example, the fermentation system contains aqueous fermentation liquid, oily substrate, protein macromolecules, air, solid impurities, etc. In order to mix or react different media such as liquids, gases, and solid particles more fully, a stirring device is usually set in the container containing the above media. The stirring device will face various resistances from different media during the mixing process, which will then cause problems such as cracking and breaking caused by fatigue, greatly affecting the mixing or reaction efficiency. Harmful resistance will also bring high energy consumption. In industrial scale-up production, the stirring device used to mix raw materials is usually large in size. If the device is replaced due to fatigue damage, it will incur high equipment costs. Therefore, there is an urgent need for a fermentation tank that is suitable for complex mixed media, has a long service life, and can be used in industrial production scale-up. Summary of the invention

[0003] The purpose of the present invention is to solve the problems existing in the fermentation reaction in the existing microbial industry, and to provide a fermentation tank, which can well mix different media such as water phase, oil phase, gas phase, solid phase in the fermentation liquid during the fermentation reaction, which is more conducive to the fermentation conversion reaction of microorganisms, improves the mixing and reaction efficiency, effectively saves the replacement cost of the equipment, and reduces energy consumption.

[0004] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0005] A fermentation tank, comprising a tank body and a stirring device, wherein the stirring device comprises:

[0006] A stirring shaft, the stirring shaft is arranged inside the tank body;

[0007] The rotary starter is connected to the stirring shaft and drives the stirring shaft to rotate in a fixed axis;

[0008] A stirring blade is arranged on the stirring shaft, and the stirring blade is provided with more than two through holes, and the through hole is provided with a liquid-facing surface and a liquid-discharging surface, and the area of ​​the liquid-facing surface is greater than or equal to the area of ​​the liquid-discharging surface, wherein the spacing between any two adjacent through holes is 0.5-10cm, preferably 1-10cm; the maximum diameter of the liquid-discharging surface is 0.2-5cm, preferably 0.5-5cm.

[0009] During use of the fermentation tank of the present invention, the stirring shaft is driven to rotate by the rotary starter, driving the stirring blades to rotate in the tank, and the fermentation liquid passes through the blade body through the liquid-facing surface of the stirring blade and flows out from the liquid outlet surface. By setting a specific through-hole spacing and liquid outlet surface size, not only efficient mixing is achieved and the fermentation reaction efficiency is improved, but also various harmful resistances and the vibration resistance of the blades and the rotating shaft caused by the blades during operation are greatly reduced, the frequency and cost of device replacement are reduced, and the energy consumption is significantly reduced by more than 10%.

[0010] The fermentation liquid of the present invention is a complex reaction system, which contains not only microorganisms, but also aqueous culture medium, aqueous or oily substrates, products required for microbial fermentation reaction, and possible impurities such as solid particles. When the microorganisms are aerobic bacteria, air or oxygen will also be mixed in the fermentation liquid, so the fermentation liquid is a complex system containing multiple different media of liquid phase, solid phase and gas phase.

[0011] Preferably, the spacing between any two adjacent through holes is 1-10 cm, such as 1 cm, 2 cm, 3 cm, 4 cm, 5 cm, 6 cm, 7 cm, 8 cm, 9 cm, 10 cm. The spacing between any two adjacent through holes refers to the straight-line distance between a through hole and the center point of the nearest adjacent through hole.

[0012] Preferably, the through holes are evenly distributed on the stirring blade.

[0013] Preferably, the maximum diameter of the liquid outlet surface is 0.5-5 cm, such as 1 cm, 2 cm, 3 cm, 4 cm, 5 cm, and further 0.6-3 cm. The spacing of the through holes on the stirring blade and the diameter of the liquid outlet surface have an important influence on achieving efficient mixing and reducing energy consumption.

[0014] Preferably, the cross section of the through hole is circular, elliptical or polygonal.

[0015] Preferably, the polygon is a convex polygon, such as any one of a triangle, a quadrilateral, a pentagon, a hexagon and a heptagon.

[0016] Preferably, the polygon is a convex polygon with rounded corners, that is, the through hole with a convex polygonal cross section is chamfered.

[0017] Preferably, the cross section, the liquid-facing surface and the liquid-discharging surface of the through hole are all circular.

[0018] Preferably, the area of ​​the liquid outlet surface is 0.7-78.5 square centimeters, preferably 0.785-50.24 square centimeters.

[0019] Preferably, the maximum diameter of the liquid-facing surface is 1-30 times, further 1.5-10 times, and further 2-6 times the maximum diameter of the liquid-discharging surface. The maximum diameter refers to the distance between the two farthest points on the edge of the cross section. When the cross section is circular, the maximum diameter is the circular diameter.

[0020] Preferably, the area of ​​the liquid-facing surface is 1-10 times, such as 1 time, 4 times, 9 times, etc., the area of ​​the liquid-discharging surface.

[0021] Preferably, the area of ​​the liquid-facing surface is larger than the area of ​​the liquid-discharging surface, or the maximum diameter of the liquid-facing surface is larger than the maximum diameter of the liquid-discharging surface, which will further increase the dissolved oxygen lifting space required for aerobic microbial fermentation, improve fermentation efficiency, further reduce resistance, and improve energy-saving effects.

[0022] Preferably, the through hole is selected from a cylindrical hole, a truncated cone hole, an inverted bowl-shaped hole or a combination thereof, preferably a truncated cone hole, a truncated cone and cylindrical combination hole, or an inverted bowl-shaped hole.

[0023] Preferably, the interior of the through hole is rounded.

[0024] Preferably, the through hole is a combination of a truncated cone and a cylindrical hole, the diameter of the liquid-facing surface is 2-6 times the diameter of the liquid-discharging surface. The bottom surface of the truncated cone hole is the liquid-facing surface, the upper surface of the truncated cone hole is the lower bottom surface of the cylindrical hole, and the upper surface of the cylindrical hole is the liquid-discharging surface.

[0025] In some specific embodiments, the through hole is Figure 2 As shown, 512 is the flow direction of the fermentation liquid passing through the blades, 513a is the liquid-facing surface, 513b is the liquid-discharging surface, 511a is a cylindrical hole, 511b is a truncated cone hole, 511d is an inverted bowl hole, and 511c is a truncated cone and cylindrical combined hole.

[0026] Preferably, the rotary starter is a driving motor arranged outside the tank body and connected to the stirring shaft through a coupling.

[0027] Preferably, the stirring blade is any one of a flat blade, a pitched blade, a disc turbine blade or a spiral blade, or a combination of several of them. Preferably, the stirring blade at least contains a disc turbine blade.

[0028] Preferably, the disc turbine blades are arranged at the lower part of the stirring shaft.

[0029] Preferably, the flat paddle blades, inclined paddle blades and spiral blades are arranged at the upper part and / or the middle part of the stirring shaft.

[0030] Preferably, the stirring blade is a combination of a disc turbine blade and a spiral blade, and the disc turbine blade and / or the spiral blade are provided with through holes.

[0031] Preferably, the disc turbine blades are V-shaped, arrow-blade-shaped, semicircular-shaped or a combination thereof.

[0032] Preferably, the disc turbine blades have 4-12 blades, preferably 4-8 blades.

[0033] Preferably, the disc turbine blades are provided in more than one group, such as two groups, three groups or more groups, at the lower part of the stirring shaft.

[0034] Preferably, the spiral blade has 2-10 blades, preferably 3-6 blades.

[0035] Preferably, the spiral blades are evenly arranged in 2 or more groups from top to bottom along the stirring shaft, for example, 2, 3, 4 or more groups.

[0036] Preferably, the diameter of the disc turbine blade is greater than or equal to the diameter of the spiral blade. The diameter refers to the diameter of a circle formed by the trajectory of the blade tip when the blade rotates.

[0037] Preferably, the diameter of the disc turbine blade is 1-2 times the diameter of the spiral blade, for example, 1 times, 1.2 times, 1.25 times, 1.5 times, 2 times, etc., preferably 1.2-1.4 times.

[0038] Preferably, the stirring device further comprises a support member arranged at the bottom or middle of the tank body, the support member comprises a sleeve sleeved outside the stirring shaft, a bushing arranged outside the sleeve and rotatable relative to the sleeve, and a support seat sleeved outside the bushing, and the support seat is fixed to the inner wall of the tank body. The support member can be used to radially constrain the swing of the stirring shaft during rotation, especially when the tank body is large in volume, the effect is significant.

[0039] Preferably, a heat exchanger is provided inside and / or outside the tank body for adjusting the temperature of the tank body and the fermentation liquid.

[0040] Preferably, the heat exchanger is selected from a coil heat exchanger, a shell and tube heat exchanger, a spiral tube heat exchanger or an outer wall jacket heat exchanger.

[0041] Preferably, a vent is provided at the lower portion of the tank body, and external gas such as air or oxygen enters the tank body from the outside through the vent, and is radially dispersed into microbubbles inside the tank body by the action of stirring blades.

[0042] Preferably, the vent is provided with a vent pipe, which is a long strip pipe with holes on the surface, a ring pipe, a square frame pipe or a combination thereof, and is most preferably a circular ring or elliptical ring vent pipe.

[0043] Preferably, the diameter of the disc turbine blade is greater than or equal to the outer diameter of the ventilation pipe.

[0044] Preferably, the diameter of the disc turbine blade is 1-2 times the outer diameter of the ventilation pipe, preferably 1.2-1.4 times, such as 1.2, 1.3, 1.4, etc.

[0045] When the mixing device of the present invention is used for microbial fermentation reaction, the gas coming out of the vent is evenly dispersed by the stirring blades with through holes, so as to increase dissolved oxygen, reduce current, and correspondingly reduce metal fatigue damage of the stirring device caused by vibration, such as cracking and breaking, thereby increasing the service life of the equipment.

[0046] Preferably, a feeding port is provided at the lower part of the tank body, and the raw materials required to be added during the fermentation process enter the tank body from the outside of the tank body through the feeding port and are radially dispersed inside the tank body by the action of stirring blades.

[0047] Preferably, the feeding port is provided with a feeding pipe, and the feeding pipe is a long strip tube with holes on the surface, a ring tube, a square frame tube or a combination thereof.

[0048] When the fermentation tank of the present invention has a stirring blade with through holes, it can evenly disperse the raw materials from the feed port, such as some oily liquid raw materials, improve the efficiency of microbial reaction, and correspondingly reduce the fatigue, damage, cracking, and breakage of the stirring device caused by fluid movement vibration, thereby increasing the service life of the equipment.

[0049] Preferably, the stirring blade is connected to the stirring shaft by a detachable connection, such as a screw or bolt connection. Preferably, the stirring components are all made of corrosion-resistant metal.

[0050] Preferably, the volume of the tank is 10-1200 cubic meters.

[0051] The fermenter of the present invention is particularly suitable for the fermentation culture of microorganisms for producing long-chain dibasic acids, amino acids such as lysine, or amino acid derivatives such as pentamethylenediamine.

[0052] The present invention also provides an application of the fermentation tank in fermentation production of long-chain dibasic acids, amino acids or amino acid derivatives.

[0053] As described above, the fermentation tank of the present invention has the following beneficial effects: the fermentation tank is provided with a stirring device, and the main innovation point is that the stirring blade is provided with more than two through holes with a liquid facing surface and a liquid outlet surface, and the spacing and size of the through holes are set. Such a setting helps to change the force condition of the stirring device, and greatly reduces the harmful resistance of the stirring device during operation while maintaining a high mixing efficiency. It is particularly suitable for complex fermentation liquid microbial conversion reaction systems, further improves the effective force of stirring and reaction, reduces resistance and consumption, greatly saves energy and cost, and improves overall efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Figure 1Shown is a schematic diagram of a fermentation tank according to Example 1 of the present invention;

[0055] Figure 2 A cross-sectional view showing different types of through holes on a mixing blade;

[0056] Figure 3 A side view (a) and a top view (b) of a disk turbine blade are shown;

[0057] Figure 4 Shown is a three-dimensional view of a semicircular disc turbine blade according to Embodiment 1 of the present invention;

[0058] Figure 5 Shown is a schematic diagram of a fermentation tank according to Example 2 of the present invention;

[0059] Figure 6 Shown is a schematic diagram of a fermentation tank according to Example 3 of the present invention;

[0060] Figure 7 Shown is a top view of the vent pipe of Example 3 of the present invention;

[0061] Component number description

[0062] 1: Tank

[0063] 2: Stirring shaft

[0064] 3: Turn the starter

[0065] 4: Disc

[0066] 5: Turbine blades

[0067] 511a: Cylindrical hole

[0068] 511b: truncated cone hole

[0069] 511c: Combination of truncated cone and cylindrical holes

[0070] 511d: Inverted bowl-shaped hole

[0071] 512: Fermentation liquid flow direction

[0072] 513a: Liquid surface

[0073] 513b: Liquid surface

[0074] 52: Blade mounting connector

[0075] 6: Spiral blade

[0076] 7: Feeding port

[0077] 8: Discharge port

[0078] 9: Support parts

[0079] 10: Heat exchanger

[0080] 11: Ventilation port

[0081] 12: Ventilation tube

[0082] 121: Ventilation holes

[0083] 13: Intake pipe DETAILED DESCRIPTION

[0084] The following is a description of the implementation of the present invention by means of specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0085] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present invention, so they have no substantial technical significance. Any modification of the structure, change of the proportion relationship or adjustment of the size, without affecting the effects and purposes that can be achieved by the present invention, should still fall within the scope of the technical content disclosed by the present invention. At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" quoted in this specification are only for the convenience of description, and are not used to limit the scope of the implementation of the present invention. The change or adjustment of their relative relationship should also be regarded as the scope of the implementation of the present invention without substantially changing the technical content.

[0086] In order to solve the problems existing in fermentation in the field of microbial industry, the present invention provides a fermentation tank. For a complex fermentation liquid system containing different media such as liquid, gas, solid particles, etc., the fermentation tank of the present invention can not only improve the mixing and fermentation conversion reaction efficiency, but also effectively save the replacement cost of the stirring device.

[0087] Example 1

[0088] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the present invention provides a fermentation tank, comprising a tank body 1 and a stirring device, wherein the stirring device comprises: a stirring shaft 2, the stirring shaft 2 is arranged inside the tank body 1; a rotary starter 3, the rotary starter 3 is connected to the stirring shaft 2, and drives the stirring shaft 2 to rotate in a fixed axis;

[0089] The stirring blade is arranged on the stirring shaft. The stirring blade includes a set of disc turbine blades and three sets of spiral blades 6. The disc turbine blade is composed of a disc 4 and eight semicircular turbine blades 5 evenly arranged along the outer edge of the disc 4. The disc 4 is fixedly arranged at the lower part of the stirring shaft 2. The semicircular turbine blades are fastened to the outer edge of the disc through blade mounting connectors 52 (such as screws and bolts). Figure 3 As shown. The spiral blades 6 are evenly arranged in 3 groups from top to bottom along the stirring shaft, the spiral blades are not provided with through holes, and the number of blades in each group of spiral blades is 6. The diameter of the disc turbine blade is 1.2 times the diameter of the spiral blade.

[0090] Among them, the semicircular turbine blade 5 is as follows Figure 4 As shown, more than two truncated cone-shaped through holes 511b are evenly distributed on the blade, and the cross-section, liquid-facing surface and liquid-discharging surface of the through holes are all circular, and the diameter of the liquid-discharging surface is 0.8 cm, the diameter of the liquid-facing surface is 1.6 cm, and the spacing between any two adjacent through holes is 4 cm.

[0091] The rotary starter is a driving motor arranged outside the tank body and connected to the stirring shaft through a coupling. The driving motor drives the stirring shaft to drive the stirring blades to rotate.

[0092] like Figure 1 As shown, the stirring device further includes a support member 9 arranged at the bottom of the tank body, the support member 9 includes a sleeve sleeved outside the stirring shaft, a bushing arranged outside the sleeve and rotatable relative to the sleeve, and a support seat sleeved outside the sleeve, and the support seat is fixed to the inner wall of the tank body. The support member can be used to radially constrain the swing of the stirring shaft during rotation.

[0093] A vent 11 is also provided at the bottom of the fermentation tank, which is used to allow external gas such as air or oxygen to enter the tank body from the outside of the tank body through the vent 11 and be radially dispersed inside the tank body by the action of stirring blades.

[0094] During use of the fermentation tank of this embodiment, fermentation liquid raw materials or supplementary materials are added through the feed port 7, the drive motor 3 arranged outside the tank body is turned on, the stirring shaft 2 rotates with the stirring blades 5 and 6, the bottom support member 9 provides an auxiliary support for the stirring shaft, and the vent 11 introduces external air or oxygen. During the rotation of the turbine blade 5, the fermentation liquid will enter from the liquid-facing surface of the through hole on the blade, quickly pass through the blade and then flow out from the liquid outlet surface. While achieving efficient mixing of the fermentation liquid, the resistance of the fermentation liquid to the stirring device is reduced, the energy consumption is further reduced, and the service life of the blade is increased. After the fermentation is completed, the drive motor is turned off, the stirring shaft stops rotating, and the fermentation liquid is discharged through the discharge port 8 to complete the fermentation conversion process.

[0095] Example 2

[0096] like Figure 5As shown, this embodiment is basically the same as embodiment 1, except that, on the basis of embodiment 1, through holes are provided on the lower two groups of spiral blades among the three groups of spiral blades, and no through holes are provided on the uppermost group of spiral blades. The through holes of the spiral blades are two or more cylindrical through holes evenly distributed, and the cross-section, liquid-facing surface, and liquid-discharging surface of the through holes are all circular, and the diameters are all 1 cm, and the spacing between any two adjacent through holes is 4 cm. This arrangement further improves the stirring and fermentation reaction efficiency on the one hand, and is also conducive to cost control on the other hand. In addition, a heat exchanger 10 is added to the inner wall of the tank body, which can be used to further adjust the temperature of the fermentation liquid, and the heat exchanger is a spiral tube heat exchanger.

[0097] Example 3

[0098] like Figure 6 As shown, this embodiment is basically the same as the embodiment 1, except that, on the basis of the embodiment 1, a vent pipe 12 and an air inlet pipe 13 are added to the lower part of the tank body, and the vent pipe 12 is a vent pipe with holes on the surface. Figure 7 The circular annular vent pipe shown has ventilation holes 121 evenly distributed on its surface. Air enters the vent pipe 12 through the vent port via the air inlet pipe 13 connected to the tank body, and is discharged from the ventilation holes 121 on the surface into the tank body. The air is evenly radially dispersed inside the tank body by the turbine blades of the stirring shaft, and is fully mixed with the fermentation liquid to increase the dissolved oxygen efficiency. A heat exchanger 10 is additionally provided on the inner wall of the tank body, which can be used to further adjust the temperature of the fermentation liquid. The heat exchanger is a shell-and-tube heat exchanger. Among them, the diameter of the disc turbine blade is 1.2 times the outer diameter of the vent pipe. This arrangement is beneficial for the turbine blades with through holes to evenly disperse the gas coming out of the vent pipe during the microbial fermentation reaction, reduce the current, and correspondingly reduce the metal fatigue damage of the stirring device caused by vibration, cracking, fracture, etc., thereby increasing the service life of the equipment and reducing energy consumption.

[0099] Comparative Example 1: The difference between the fermentation tank in this comparative example and that in Example 1 is that all the stirring blades are not provided with through holes.

[0100] Comparative Example 2: The difference between the fermentation tank in this comparative example and that in Example 1 is that the distance between any two adjacent through holes on the disc turbine blade is 15 cm.

[0101] Comparative Example 3: The difference between the fermentation tank in this comparative example and that in Example 1 is that the area of ​​the liquid-facing surface is smaller than the area of ​​the liquid-discharging surface, the diameter of the liquid-discharging surface is 3 cm, and the diameter of the liquid-facing surface is 1 cm.

[0102] Effect examples and comparative examples:

[0103] Referring to the method disclosed in Example 5 of the invention patent CN121748480B, the fermentation tanks of the above Examples 1-3 and Comparative Examples 1-3 were used to ferment and produce C12 dibasic acid, and the volume of the fermentation tanks was 20L. After the fermentation was completed, the acid production was detected, the energy consumption reduction percentage was calculated, and the replacement cycle of the stirring blades due to damage was calculated. The energy consumption reduction percentage = (actual energy consumption - energy consumption of comparative example 1) / actual energy consumption.

[0104] The results are shown in Table 1 below:

[0105] Table 1

[0106]

[0107] As can be seen from Table 1, the present invention provides more than two through holes with liquid-facing surfaces and liquid-discharging surfaces on the stirring blades, and sets specific through-hole spacing and sizes. When fermenting and producing C12 dibasic acid, energy consumption is greatly reduced on the premise of obtaining a higher acid production. A reduction of more than 10% in energy consumption is equivalent to achieving an unexpected technical effect, and the replacement cycle of the stirring device is significantly extended. The fermenter of the present invention has a very important application prospect in the actual industrial production process.

[0108] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A fermentation tank, comprising a tank body and a stirring device, wherein the stirring device comprises: A stirring shaft, the stirring shaft is arranged inside the tank body; The rotary starter is connected to the stirring shaft and drives the stirring shaft to rotate in a fixed axis; A stirring blade is arranged on the stirring shaft, and the stirring blade is provided with more than two through holes, the through holes are provided with a liquid-facing surface and a liquid-discharging surface, and the area of ​​the liquid-facing surface is greater than or equal to the area of ​​the liquid-discharging surface, wherein the spacing between any two adjacent through holes is 0.5-10 cm, and the maximum diameter of the liquid-discharging surface is 0.2-5 cm.

2. The fermentation tank according to claim 1, characterized in that The cross section of the through hole is circular, elliptical or polygonal; Preferably, the polygon is a convex polygon; Preferably, the polygon is a convex polygon with rounded corners.

3. The fermentation tank according to claim 1, characterized in that The area of ​​the liquid outlet surface is 0.7-78.5 square centimeters, preferably 0.785-50.24 square centimeters.

4. The fermentation tank according to claim 1, characterized in that The maximum diameter of the liquid-facing surface is 1-30 times, further 1.5-10 times, and further 2-6 times the maximum diameter of the liquid-discharging surface.

5. The fermentation tank according to claim 1, characterized in that The through hole is selected from a cylindrical hole, a truncated cone hole, an inverted bowl hole or a combination thereof.

6. The fermentation tank according to claim 1, characterized in that: The stirring blade is any one or a combination of flat blades, inclined blades, disc turbine blades or spiral blades; Preferably, the stirring blades include at least disc turbine blades.

7. The fermentation tank according to claim 6, characterized in that The disc turbine blades are arranged at the lower part of the stirring shaft, and / or the flat-paddle blades, inclined-paddle blades or spiral blades are arranged at the upper part or / and the middle part of the stirring shaft.

8. The fermentation tank according to claim 6, characterized in that The stirring blade is a combination of a disc turbine blade and a spiral blade, and a through hole is provided on the disc turbine blade or / and the spiral blade; Preferably, the disc turbine blades are V-shaped, arrow-blade-shaped, semicircular-shaped or a combination thereof; Preferably, the number of blades of the disc turbine blade is 4-12; Preferably, the number of blades of the spiral blade is 2-10; Preferably, the spiral blades are evenly arranged in 2 groups or more from top to bottom along the stirring shaft; Preferably, the diameter of the disc turbine blade is greater than or equal to the diameter of the spiral blade.

9. The fermentation tank according to claim 1, characterized in that: The stirring device also includes a support member arranged at the bottom or middle of the tank body, the support member includes a sleeve mounted outside the stirring shaft, a bushing mounted outside the sleeve and rotatable relative to the sleeve, and a support seat mounted outside the bushing, and the support seat is fixed to the inner wall of the tank body.

10. The fermenter according to claim 1, characterized in that: A heat exchanger is provided inside and / or outside the tank body; preferably, the heat exchanger is selected from a coil heat exchanger, a shell and tube heat exchanger, a spiral tube heat exchanger or an outer wall jacket heat exchanger.

11. The fermentation tank according to claim 1, characterized in that: The lower part of the tank body is provided with a vent and / or a feed port; Preferably, the vent is provided with a vent pipe, and the vent pipe is a long strip pipe with holes on the surface, a ring pipe, a square frame pipe or a combination thereof; Preferably, the feeding port is provided with a feeding pipe, and the feeding pipe is a long strip tube with holes on the surface, a ring tube, a square frame tube or a combination thereof.

12. Use of the fermenter according to any one of claims 1 to 11 in the fermentation production of long-chain dibasic acids, amino acids or amino acid derivatives.

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