Sample treatment and incubation system

Abstract

The invention discloses a sample treatment and incubation system which comprises a machine body, a plurality of guide shafts and a loading platform are vertically arranged in the machine body, guide holes allowing the guide shafts to penetrate through are formed in the loading platform, a lifting extraction device is arranged in the machine body, the lifting extraction device is fixedly connected with the lower portion of the loading platform, and an oscillation mixing device is arranged on the loading platform. The lifting extraction device is used for controlling the loading platform to move up and down along the guide shaft, a loading hole for loading a sample bottle is formed in the oscillation mixing device, a top plate is arranged above the loading platform, and the top plate is fixedly connected to the upper end of the guide shaft. The adapters and the sample bottles can be rapidly pressed in batches through the lifting extraction device, and the extraction function of the adapters can be enhanced by utilizing the pressure of the lifting extraction device on the adapters; and the oscillation mixing device is also integrated, so that the oscillation mixing operation on the sample bottle can be automatically realized, the working intensity is reduced, and the working efficiency is greatly improved.

Description

Technical Field

[0001] The invention relates to a laboratory appliance, in particular to a sample processing and incubation system. Background Art

[0002] In the field of analysis, trace amounts of liquid samples are sometimes collected during the sample collection process, such as serum, plasma, urine, saliva, cerebrospinal fluid, tears, digestive fluid, etc. for testing.

[0003] The applicant previously applied for a patent number: CN221412342U, entitled: An invention patent for a filter tip, an adapter and a micro-volume ultrafiltration bottle, which discloses a sample bottle with a filtering function formed by a combination of an adapter and a bottle body. After the liquid sample is collected into the bottle body, the adapter needs to be manually inserted from the bottle mouth to prevent the liquid sample from spilling during transportation; however, when the number of sample bottles is too large, the operator needs to press the adapters into the bottle body one by one, which takes a lot of time and has low work efficiency.

[0004] Patent No.: "CN208135852U" discloses a sample injection bottle capping device, including a sample injection bottle, a fixing frame for fixing the sample injection bottle, and a capping operation table; the capping operation table includes a lower support plate, an upper support plate, a supporting fixing column fixedly connecting the lower support plate and the upper support plate, a pressing handle and a sliding rod, and a gap for accommodating the fixing frame is formed between the lower support plate and the upper support plate; a through hole is provided at a position corresponding to the upper support plate and the sample injection bottle, and accordingly, a columnar protrusion for pressing the bottle cap is provided on one side corresponding to the pressing handle and the upper support plate, and the columnar protrusion is adapted to the through hole; the sliding rod is slidably arranged on the upper end surface of the upper support plate, and the pressing handle is provided with a sliding hole adapted to the diameter of the sliding rod, and the pressing handle is slidably connected to the sliding rod. However, the above solution still requires manual pressing of the pressing handle to press the bottle cap into the injection bottle. However, in this process, it is impossible to ensure that the pressing force is maintained within a safe range each time. Once the pressing force is too large, the injection bottle will be at risk of breaking, and the liquid sample in the bottle will flow out. Resampling is particularly cumbersome or even impossible. In addition, existing fluid sample pretreatment devices are usually difficult to achieve effective sample mixing. To mix the sample evenly, an additional machine is required to achieve the sample mixing operation, which is cumbersome. Therefore, it is urgent to design a sample processing and incubation system to solve the above problems. Summary of the invention

[0005] In view of the deficiencies in the prior art, the object of the present invention is: Solve the problem of low efficiency of manual capping and unguaranteed capping quality in the prior art; The existing technology requires manual replacement of samples and mixing operations, which results in a cumbersome pre-treatment process.

[0006] The technical solution of the present invention is: the present invention provides a sample processing and incubation system, including a fuselage, a plurality of guide shafts and a loading platform are vertically arranged in the fuselage, a guide hole for the guide shaft to pass through is arranged on the loading platform, a lifting and extraction device is arranged in the fuselage, the lifting and extraction device is fixedly connected to the bottom of the loading platform, an oscillation and mixing device is arranged on the loading platform, the lifting and extraction device is used to control the loading platform to move up and down along the guide shaft, a loading hole for loading a sample bottle is arranged in the oscillation and mixing device, a top plate is arranged above the loading platform, and the top plate is fixedly connected to the upper end of the guide shaft.

[0007] Preferably, the lifting and extraction device includes a lifting motor, a screw shaft and a lifting sleeve, one end of the screw shaft is connected to the output shaft of the lifting motor, a screw nut is sleeved on the screw shaft, the other end of the screw shaft extends into the lifting sleeve, one end of the lifting sleeve close to the lifting motor is fixedly connected to the screw nut, and the other end of the lifting sleeve is fixedly connected to the bottom of the loading platform.

[0008] Preferably, the oscillation and mixing device includes an oscillation motor, an eccentric wheel insert, and a perforated plate base. The oscillation motor is fixedly connected to the device platform. A horizontal slide bar is provided on the loading platform. The perforated plate base is provided with a through hole for the horizontal slide bar to pass through. The loading hole is provided on the perforated plate base. An eccentric wheel is sleeved on the output shaft of the oscillation motor. The eccentric wheel insert is fixedly connected to the bottom surface of the perforated plate base. A vibration groove is provided on the eccentric wheel insert, and the eccentric wheel is placed in the vibration groove.

[0009] Preferably, a well plate adapter is further provided on the well plate base, the well plate adapter is detachably connected to the well plate base, and a large number of auxiliary loading holes for loading sample bottles are provided on the well plate adapter.

[0010] Preferably, the vibration groove is a strip groove, the long side of the vibration groove is perpendicular to the axis of the horizontal slide bar, a radial bearing is sleeved on the eccentric wheel, and the radial bearing is clearance-matched with the vibration groove.

[0011] Preferably, a spring is sleeved on the horizontal sliding rod, one end of the spring abuts against the loading platform, and the other end of the spring abuts against the orifice plate base.

[0012] Preferably, a cover plate is provided on the periphery of the fuselage, and the cover plate encloses the fuselage to form a box. A photoelectric sensor is provided on the inner side of the box. A through groove for the photoelectric sensor to pass through is provided on the loading platform. A positioning pin is provided in the through groove. The photoelectric sensor determines the position of the loading platform by identifying the positioning pin.

[0013] Preferably, a sleeve is provided in the guide hole and the through hole, and the sleeve is interference connected with the loading platform and the orifice plate base.

[0014] Preferably, the lifting motor is coaxially connected to the screw rod through a coupling.

[0015] Preferably, a thrust bearing is provided between the coupling and the lifting motor.

[0016] Preferably, the front of the box is provided with a placement hole for placing the sample bottle, and the front of the box is also provided with a display screen for displaying the working status.

[0017] Compared with the prior art, the advantages of the present invention are: The invention is an automated machine, which improves work efficiency and reduces labor intensity.

[0018] The present invention is equipped with a lifting extraction device, which can apply pressure to multiple sample bottles and their adapters at the same time, further improving the capping efficiency while enhancing the extraction effect of the adapter on liquid-liquid separation and / or solid-liquid separation of the sample liquid.

[0019] The present invention is equipped with an oscillating and mixing device, which can realize the sample processing procedure of oscillating and mixing the sample, improves the integration of the system, and greatly improves the work efficiency.

[0020] The detailed structure of the present invention is further described below in conjunction with the accompanying drawings and specific implementation methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall appearance of the present invention; Figure 2 It is a schematic diagram of the internal structure of the present invention; Figure 3 It is a cross-sectional view of the internal structure of the present invention; Figure 4 It is a schematic diagram of the structure of the oscillating mixing device of the present invention; Figure 5 A top view of the oscillating mixing device of the present invention; Figure 6 It is a schematic structural diagram of the vibrating eccentric wheel insert of the present invention.

[0022] The names of the components and their corresponding serial numbers are as follows: 1. Body; 2. Top plate; 3. Guide shaft; 4. Loading platform; 5. Lifting extraction device; 6. Oscillation mixing device; 7. Lifting motor; 8. Screw shaft; 9. Screw nut; 10. Lifting sleeve; 11. Coupling; 12. Oscillation motor; 13. Eccentric wheel; 14. Radial bearing; 15. Eccentric wheel insert; 16. Orifice plate base; 17. Sample bottle; 18. Adapter; 19. PCB circuit board; 20. Vibration trough; 21. Horizontal slide bar; 22. Spring; 23. Loading hole; 24. Photoelectric sensor; 25. Positioning pin; 26. Sleeve; 27. Pick-up and drop hole; 28. Display; 29. ​​Guide hole; 30. Orifice plate adapter; 31. Auxiliary loading hole. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. The components of the embodiments of the present invention generally described and shown in the drawings here can be arranged and designed in various different configurations. The following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0024] Unless otherwise defined, the technical or scientific terms used in the present disclosure shall have the usual meanings understood by persons with ordinary skills in the field to which the present disclosure belongs. The words "including" or "comprising" and the like used in the present disclosure mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. The words "connect" or "connected" and the like are not limited to physical or mechanical connections, but may also include electrical connections, whether direct or indirect. "Up", "down", "left", "right", etc. are only used to indicate relative position relationships. When the absolute position of the object being described changes, the relative position relationship may also change accordingly.

[0025] like Figure 1-3As shown: The present invention provides a sample processing and incubation system, including a body 1, in which a plurality of guide shafts 3 and a loading platform 4 are vertically arranged, and a guide hole 29 for the guide shaft 3 to pass through is provided on the loading platform 4, and a lifting and extracting device 5 is provided in the body 1, and the lifting and extracting device 5 is fixedly connected to the bottom of the loading platform 4, and an oscillation mixing device 6 is provided on the loading platform 4, and the lifting and extracting device 5 is used to control the loading platform 4 to move up and down along the guide shaft 3, and a loading hole 23 for loading a sample bottle 17 is provided in the oscillation mixing device 6, and a top plate 2 is provided above the loading platform 4, and the top plate 2 is fixedly connected to the upper end of the guide shaft 3. The lifting extraction device 5 can move the loading platform 4 together with the oscillating and mixing device 6, the sample bottle 17 placed in the loading hole 23, and the adapter 18 simply placed in the sample bottle 17 upward along the guide shaft 3, so that the adapter 18 is finally pressed against the bottle mouth of the sample bottle 17 under the pressure of the top plate 2. At the same time, under the pressure of the top plate 2 and the lifting extraction device 5, the extraction effect of the adapter 18 on the sample liquid is further enhanced; at the same time, when the sample liquid needs to be oscillated and mixed, it is only necessary to control the oscillating and mixing device 6 to start, and the oscillating and mixing device 6 will drive the sample bottle 17 to oscillate, thereby achieving uniform mixing of the sample liquid.

[0026] Specifically, the lifting extraction device 5 includes a lifting motor 7, a screw shaft 8 and a lifting sleeve 10. One end of the screw shaft 8 is connected to the output shaft of the lifting motor 7. A screw nut 9 is sleeved on the screw shaft 8. The other end of the screw shaft 8 extends into the lifting sleeve 10. The end of the lifting sleeve 10 close to the lifting motor 7 is fixedly connected to the screw nut 9. The other end of the lifting sleeve 10 is fixedly connected to the bottom of the loading platform 4. The start and stop, speed and number of revolutions of the lifting motor 7 can be directly controlled. When the lifting motor 7 is started, the lifting motor 7 transmits power to the screw shaft 8 to drive the screw shaft 8 to rotate. Since the screw nut 9 and the lifting sleeve 10 are fixedly connected to the bottom of the loading platform 4, the screw nut 9 will move up and down along the screw shaft 8 when the screw shaft 8 rotates, thereby realizing the up and down lifting of the transfer platform along the guide shaft 3.

[0027] Specifically, see Figure 4-6The oscillation mixing device 6 includes an oscillation motor 12, an eccentric wheel insert 15, and a perforated plate base 16. The oscillation motor 12 is fixedly connected to the device platform. A horizontal slide bar 21 is provided on the loading platform 4. The perforated plate base 16 is provided with a through hole for the horizontal slide bar 21 to pass through. The loading hole 23 is provided on the perforated plate base 16. An eccentric wheel 13 is sleeved on the output shaft of the oscillation motor 12. The eccentric wheel insert 15 is fixedly connected to the bottom surface of the perforated plate base 16. A vibration groove 20 is provided on the eccentric wheel insert 15. The eccentric wheel 13 is placed in the vibration groove 20. The start and stop and running time of the oscillation motor 12 can be controlled. When the oscillation motor 12 is started, the oscillation motor 12 will drive the eccentric wheel 13 to rotate in the vibration groove 20, thereby driving the eccentric wheel insert 15 and the perforated plate base 16 to reciprocate on the horizontal slide bar 21 to achieve the effect of oscillation mixing.

[0028] Furthermore, a well plate adapter 30 is provided on the well plate base 16, and the well plate adapter 30 is detachably connected to the well plate base 16, and a large number of auxiliary loading holes 31 for loading sample bottles are provided on the well plate adapter 30. The number of the loading holes 23 is relatively small (10 in this embodiment), and the purpose is to process the situation where a single batch is less than or equal to 10 sample bottles; and the number of the auxiliary loading holes 31 is much larger than the number of the loading holes 23, and the purpose is to process the situation where a single batch has a large number of sample bottles that need to be processed.

[0029] Specifically, the vibration groove 20 is a strip groove, the long side of which is perpendicular to the axis of the horizontal slide bar 21, and a radial bearing 14 is sleeved on the eccentric wheel 13, and the radial bearing 14 is clearance-matched with the vibration groove 20, specifically: the groove width of the vibration groove 20 is greater than or equal to the diameter of the radial bearing 14, and the groove width is less than or equal to 2 times the radius of the radial bearing 14 + 2 times the eccentricity.

[0030] Specifically, a spring 22 is sleeved on the horizontal slide bar 21, one end of the spring 22 abuts against the loading platform 4, and the other end of the spring 22 abuts against the orifice plate base 16, so as to buffer the loading platform 4 when it makes a reciprocating motion.

[0031] Specifically, a cover plate is provided on the periphery of the body 1, and the cover plate encloses the body 1 to form a box, and a photoelectric sensor 24 is provided on the inner side of the box, and a through slot for the photoelectric sensor 24 to pass through is provided on the loading platform 4, and a positioning pin 25 is provided in the through slot, and the photoelectric sensor 24 determines the position of the loading platform 4 by identifying the positioning pin 25. When the photoelectric sensor 24 identifies the positioning pin 25, that is, the loading platform 4 moves to the zero position, the system will complete the work task, and the operator can take the processed sample bottles 17 and load a new batch of newly collected sample bottles 17 that have not been processed.

[0032] Specifically, the guide hole 29 and the through hole are provided with a sleeve 26, and the sleeve 26 is interference-connected with the loading platform 4 and the orifice plate base 16. The sleeve 26 replaces the loading platform 4 and the orifice plate base 16 to directly contact the guide shaft 3 and the horizontal slide bar 21 to avoid wear.

[0033] In this embodiment, the output shaft of the lifting motor 7 and the screw shaft 8 are coaxially connected through a coupling 11, but the present invention is not limited to this connection method. Any transmission connection between the output shaft of the lifting motor 7 and the screw shaft 8, such as gear transmission, pulley transmission, sprocket transmission, installation of a reducer, etc., are all within the protection scope of the present invention.

[0034] Specifically, a thrust bearing is provided between the coupling 11 and the lifting motor 7 to improve the axial bearing capacity of the coupling 11 and the screw shaft 8, and to prevent the axial bearing pressure of the coupling from being too large and contacting with the housing of the lifting motor 7 to cause friction.

[0035] Specifically, the front of the box is provided with a retrieval hole 27 for placing the sample bottle 17, and the front of the box is also provided with a display screen 28 for displaying the working status, wherein the display screen 28 is a touch screen, and the display screen 28 can be set to control the parameters of the oscillation mixing intensity and the lifting and lowering extraction, that is, to adjust the motor speed and acceleration to achieve free configuration; it is convenient for the operator to observe the working status of the present application and its work progress.

[0036] Specifically, a PCB circuit board 19 is provided in the body 1 , and the lifting motor 7 , the oscillation motor 12 , the photoelectric sensor 24 and the display 28 are all electrically connected to the PCB circuit board 19 .

[0037] Working process and principle: The loading platform 4 is initially at zero position, and the staff can load the sample bottle 17 and its adapter 18 through the access hole 27. After loading, the staff can operate and start the device of the present invention, the lifting motor 7 rotates forward, the lifting motor 7 drives the screw shaft 8 to rotate, and the screw nut 9 supports the lifting sleeve 10, the loading platform 4, the oscillation mixing device 6 and the sample bottle 17 to move upward along the screw shaft 8 until the adapter 18 in the sample bottle 17 gradually presses the bottle mouth of the sample bottle 17 under the mutual compression of the screw nut 9 and the top plate 2, completing the capping operation; then the lifting motor 7 is reversed, the screw nut 9 drives the sample bottle 17 to move downward along the screw shaft 8 for a distance, the lifting motor 7 stops, and then the oscillation motor 12 is started, and the oscillation motor 12 drives the eccentric wheel 13 to rotate in the vibration groove 20, so that the eccentric wheel insert 15 The orifice plate base 16 is pushed to reciprocate along the axial direction of the horizontal slide bar 21 to achieve the oscillation and mixing effect of the sample bottle 17; then the lifting motor 7 rotates forward again, so that the sample bottle 17 is again squeezed by the screw nut 9 and the top plate 2, and lasts for a period of time. During this process, since the adapter 18 is continuously pressurized, the extraction effect of the tail end of the adapter 18 on the sample liquid is enhanced; after the extraction is completed, the lifting motor 7 is reversed, and the screw nut 9 drives the sample bottle 17 to move downward along the screw shaft 8 again until the photoelectric sensor 24 recognizes the positioning pin 25 on the loading platform 4, proving that the transfer platform has returned to the zero position, and the staff can take the sample bottle 17 that has completed the sample processing and reload the sample bottle 17 that has not been processed through the access hole 27; the above work processes can be displayed on the display screen on the front of the box.

[0038] An example of workflow control parameters in the embodiment: 1. Capping: The lifting motor 7 rotates forward at a speed of 0.2r / s to push the sample bottle to height 1 (the lifting motor 7 runs 4.5 circles) and then stands for 4 seconds; 2. Oscillation: The lifting motor 7 reverses and pushes the sample bottle at a speed of 0.2 r / s, and stops after running to height 2 (the lifting motor 7 runs 2 circles), and then the vibration motor 12 runs at a speed of 10 r / s, and stops after continuing for 30 seconds.

[0039] 3. Extraction: The lifting motor 3 pushes the sample bottle at a speed of 4r / s to a height of 3 (the motor 3 runs 4 circles) and then stands still for 8 seconds; 3. Return to position: Motor 3 pushes the sample bottle at a speed of 4r / s to return to the zero position (the photoelectric sensor recognizes the positioning pin).

[0040] The above is a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, can make equivalent replacements or changes according to the technical solutions and concepts of the present invention, which should be covered by the protection scope of the claims of the present invention.

Claims

1. A sample processing and incubation system, characterized in that: The invention comprises a body (1), wherein a plurality of guide shafts (3) and a loading platform (4) are vertically arranged in the body (1), wherein the loading platform (4) is provided with guide holes (29) for the guide shafts (3) to pass through, wherein a lifting and extracting device (5) is arranged in the body (1), wherein the lifting and extracting device (5) is fixedly connected to the lower part of the loading platform (4), wherein an oscillating and mixing device (6) is arranged on the loading platform (4), wherein the lifting and extracting device (5) is used to control the loading platform (4) to move up and down along the guide shafts (3), wherein a loading hole (23) for loading a sample bottle (17) is arranged in the oscillating and mixing device (6), and wherein a top plate (2) is fixedly connected to the upper end of the guide shafts (3).

2. A sample processing and incubation system according to claim 1, characterized in that: The lifting extraction device (5) comprises a lifting motor (7), a screw shaft (8) and a lifting sleeve (10), one end of the screw shaft (8) is connected to the output shaft of the lifting motor (7), a screw nut (9) is sleeved on the screw shaft (8), the other end of the screw shaft (8) extends into the lifting sleeve (10), one end of the lifting sleeve (10) close to the lifting motor (7) is fixedly connected to the screw nut (9), and the other end of the lifting sleeve (10) is fixedly connected to the bottom of the loading platform (4).

3. A sample processing and incubation system according to claim 1, characterized in that: The oscillating mixing device (6) comprises an oscillating motor (12), an eccentric wheel insert (15), and a perforated plate base (16); the oscillating motor (12) is fixedly connected to the device platform; a horizontal slide bar (21) is provided on the loading platform (4); the perforated plate base (16) is provided with a through hole for the horizontal slide bar (21) to pass through; the loading hole (23) is provided on the perforated plate base (16); an eccentric wheel (13) is sleeved on the output shaft of the oscillating motor (12); the eccentric wheel insert (15) is fixedly connected to the bottom surface of the perforated plate base (16); a vibration groove (20) is provided on the eccentric wheel insert (15); and the eccentric wheel (13) is placed in the vibration groove (20).

4. A sample processing and incubation system according to claim 3, characterized in that: The orifice plate base (16) is also provided with an orifice plate adapter platform (30), the orifice plate adapter platform (30) is detachably connected to the orifice plate base (16), and the orifice plate adapter platform (30) is provided with a large number of auxiliary loading holes (31) for loading sample bottles.

5. A sample processing and incubation system according to claim 3, characterized in that: The vibration groove (20) is a strip-shaped groove, the long side of which is perpendicular to the axis of the horizontal slide bar (21), and a radial bearing (14) is sleeved on the eccentric wheel (13), the radial bearing (14) being clearance-matched with the vibration groove (20).

6. A sample processing and incubation system according to claim 3, characterized in that: A spring (22) is also sleeved on the horizontal sliding rod (21), one end of the spring (22) abuts against the loading platform (4), and the other end of the spring (22) abuts against the orifice plate base (16).

7. A sample processing and incubation system according to any one of claims 1 to 6, characterized in that: A cover plate is provided on the periphery of the fuselage (1), the cover plate enclosing the fuselage (1) to form a box body, a photoelectric sensor (24) is provided on the inner side of the box body, a through slot for the photoelectric sensor (24) to pass through is provided on the loading platform (4), a positioning pin (25) is provided in the through slot, and the photoelectric sensor (24) determines the position of the loading platform (4) by identifying the positioning pin (25).

8. A sample processing and incubation system according to any one of claims 1 to 6, characterized in that: A sleeve (26) is provided in the guide hole (29) and the through hole, and the sleeve (26) is interference-connected with the loading platform (4) and the orifice plate base (16).

9. A sample processing and incubation system according to any one of claims 1 to 6, characterized in that: The lifting motor (7) is coaxially connected to the screw rod via a coupling (11); a thrust bearing is provided between the coupling (11) and the lifting motor (7).

10. A sample processing and incubation system according to any one of claims 1 to 6, characterized in that: The front of the box is provided with a placement hole (27) for placing a sample bottle (17) for use, and the front of the box is also provided with a display screen for displaying the working status.

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