Potassium chloride particle composition particle and industrialization process

Abstract

The invention relates to the technical field of chemical medicine particle preparation preparation processes, in particular to potassium chloride particle composition particles and an industrialization process. The industrialization process specifically comprises the following steps: carrying out swinging granulation treatment on a potassium chloride raw material to obtain potassium chloride square crystals; the potassium chloride square crystals are subjected to water moistening and rounding treatment, and potassium chloride smooth particles are obtained; coating the smooth potassium chloride particles with a coating solution containing a flavoring agent and a coloring agent to obtain modified and colored potassium chloride particles; mixing the modified and colored potassium chloride particles with essence and a flow aid in sequence to obtain a potassium chloride particle finished product. According to the technical scheme, the technical problem that product quality and performance of potassium chloride particles in the prior art are difficult to guarantee under the condition that excessive auxiliary materials are not introduced can be solved, and the potassium chloride particles have ideal popularization and application prospects.

Description

Technical Field

[0001] The invention relates to the technical field of chemical medicine granule preparation technology, and in particular to a potassium chloride granule composition particle and an industrialization process. Background Art

[0002] Hypokalemia is a common electrolyte disorder in clinical practice. Oral potassium supplementation is the safest. Existing oral potassium supplement preparations mainly include oral liquid, sustained-release tablets, sustained-release capsules, granules, powders, etc. Potassium chloride granules are dissolved and then taken orally, mainly used to supplement potassium ions in the body to treat or prevent hypokalemia.

[0003] Chinese patent CN118384114A (a potassium chloride granule and its preparation process) discloses the following content: by weight, the raw materials of the potassium chloride granule include: 14-16 parts of potassium chloride, 0.1-0.2 parts of a regulator, 0.1-0.2 parts of a flow aid, 0.05-0.2 parts of a flavoring agent, 0.3-0.4 parts of a sweetener, 0.02-0.1 parts of a colorant and 0.15-0.25 parts of a fragrance; wherein the regulator is a mixture of mannitol, hydroxypropyl β-cyclodextrin and arginine. The potassium chloride granules prepared by the invention have uniform appearance, good content uniformity and good fluidity. By adding mannitol, hydroxypropyl β-cyclodextrin and arginine as regulators, the problems of unsmooth preparation process and poor content uniformity caused by the hygroscopicity and easy agglomeration of potassium chloride are further overcome. However, adding regulators such as mannitol, hydroxypropyl β-cyclodextrin and arginine to potassium chloride granules increases the raw material cost of the product, and the types of auxiliary materials in the medicine or the amount of addition are too much, which may cause some potential adverse reactions. On the contrary, since potassium chloride granules have a certain hygroscopicity, if similar auxiliary materials are not added to potassium chloride granules, it may cause poor particle fluidity (affecting the process speed and fluency in large-scale production), or cause uneven particle coloring, or cause excessive hygroscopicity of the particles. Therefore, how to improve the product quality of potassium chloride granules without introducing too many auxiliary materials is a problem to be solved in this field. Summary of the invention

[0004] The present invention aims to provide an industrial process for preparing potassium chloride granule composition particles, so as to solve the technical problem that it is difficult to ensure product quality and performance of potassium chloride granules in the prior art without introducing too many auxiliary materials.

[0005] In order to achieve the above object, the present invention adopts the following technical scheme:

[0006] An industrial process for preparing potassium chloride granule composite particles comprises the following steps performed in sequence:

[0007] S1 Preparation of smooth potassium chloride granules: subjecting the potassium chloride raw material to a swing granulation process to obtain potassium chloride prismatic crystals; subjecting the potassium chloride prismatic crystals to a water-spheronization process to obtain smooth potassium chloride granules;

[0008] S2 Potassium chloride granules flavoring and coloring: Use a coating solution containing flavoring agents and coloring agents to coat the smooth potassium chloride granules to obtain flavoring and coloring potassium chloride granules;

[0009] S3 Potassium Chloride Granules Fragrance and Water Sealing: The flavored and colored potassium chloride granules are sequentially mixed with flavoring agents and flow aids to obtain finished potassium chloride granules.

[0010] Furthermore, in S1, the sieve for the swing granulation is a 12-16 mesh sieve.

[0011] Further, in S1, the method of using water to moisten and spheronize the potassium chloride prismatic crystals is as follows: the potassium chloride prismatic crystals are added to a sugar coating machine, the air inlet temperature is set to 60-70°C, the coating pan speed is set to 15-20 rpm, and the spray speed is set to 1-2 ml / min, water is sprayed in, and then drying and spheronization are continued to obtain smooth potassium chloride particles.

[0012] Furthermore, in S1, the amount of water used is 30% to 40% by weight of potassium chloride.

[0013] Furthermore, in S1, the drying and spheronization time is 120 to 160 minutes.

[0014] Further, in S2, the coating liquid containing the flavoring agent and the coloring agent is used to coat the potassium chloride smooth granules in the following manner: the sweet flavoring agent is prepared into a solution with a concentration of 30% to 40% (w / v), and then the sour flavoring agent and the coloring agent are added, and the flavoring agent and the coloring agent are obtained after stirring and dissolving; the air inlet temperature is set to 60 to 70° C., the coating pan speed is set to 15 to 20 rpm, and the spraying speed is set to 1 to 2 ml / min, and the flavoring agent and the coloring agent solution is sprayed, and then dried for 20 to 30 minutes.

[0015] Furthermore, in S3, the flavor and the flow aid are both sieved through a 150-200 mesh sieve and then mixed with the flavored and colored potassium chloride granules; the mixing speed is 15-20 rpm and the mixing time is 10-20 minutes.

[0016] The technical solution also provides potassium chloride particles prepared by an industrial process for preparing potassium chloride particle composition particles.

[0017] Furthermore, the potassium chloride granules, in parts by weight, include 1350-1650 parts of potassium chloride, 7-8 parts of a regulator, 3-6 parts of a colorant, 20-40 parts of a sweetener, 5-15 parts of a flow aid, and 5-15 parts of an essence.

[0018] Furthermore, the glidant includes at least one of micro-powdered silica gel, talcum powder, and polyethylene glycol 4000-6000;

[0019] The colorant includes at least one of FD&C Yellow #6 pigment and carmine pigment;

[0020] The sour flavoring agent includes at least one of anhydrous citric acid and fumaric acid;

[0021] The sweet flavoring agent includes at least one sweetener selected from sucralose, steviol glycoside, saccharin sodium and aspartame;

[0022] The flavor includes at least one of orange flavor, strawberry flavor, banana flavor and mint flavor.

[0023] The principle and beneficial effects of this technical solution are:

[0024] This technical solution is different from the conventional production method of potassium chloride granules in the prior art. Under the premise of not adding any adhesive, the potassium chloride granule product is prepared by an appropriate process. The process ensures the uniformity of the size and color of the potassium chloride granules, improves the fluidity of the granules, and reduces the hygroscopicity of the granules. This technical solution first uses a swing granulator to granulate the potassium chloride raw material, and obtains potassium chloride prisms by setting the mesh aperture of the swing granulator to 12 to 16 meshes. Then, the potassium chloride prisms are moistened and rounded with purified water to obtain smooth potassium chloride granules. Among them, during the moistening process, the water spray speed is controlled to be 1 to 2 ml / min, and the amount of water is 30% to 40% of the weight of potassium chloride. After the water spray is completed, the drying and rounding is carried out for 120 to 160 minutes. Next, the flavor correction, coloring and fragrance sealing water treatment are carried out to obtain the finished potassium chloride granules. Through the above process, the product quality defects caused by not adding adhesives can be overcome.

[0025] The beneficial effects of this technical solution are summarized as follows:

[0026] (1) This process solves the particle size problem of potassium chloride (needle-shaped and columnar crystals with extremely poor fluidity). The particles prepared by this process are smooth and round with particularly good fluidity, solving the problem of poor fluidity in the existing process.

[0027] (2) The problems of poor color uniformity and unqualified properties of potassium chloride particles have been solved.

[0028] (3) The appropriate process method is adopted without destroying the potassium chloride crystal lattice, and the particle structure is sealed with micro-powder silica gel to solve the problem of potassium chloride easily absorbing moisture.

[0029] (4) The various steps of the process are connected, making it easy to realize industrialization. In particular, the potassium chloride particles have good fluidity, which can further improve the process efficiency of industrial production.

[0030] (5) Without adding materials such as binders, it is difficult to prepare potassium chloride granules by conventional wet granulation or dry granulation. This technical solution breaks the convention. In the treatment of potassium chloride raw materials, this process is very advanced and uses simple conventional equipment to solve the long-standing difficulty in controlling the particle size of the raw materials of this product. DETAILED DESCRIPTION

[0031] The following examples are only used to more clearly illustrate the technical solutions of the present invention, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present invention. The specific embodiments listed in the present invention are only examples of the present invention, and the present invention is not limited to the specific embodiments described below. For those skilled in the art, any equivalent modifications and substitutions to the embodiments described below are also within the scope of the present invention. Therefore, equal transformations and modifications made without departing from the spirit and scope of the present invention should be included in the scope of the present invention. In order to better illustrate the present invention, numerous specific details are given in the specific embodiments below. Those skilled in the art should understand that the present invention can also be implemented without certain specific details. In other embodiments, methods, means, equipment and steps well known to those skilled in the art are not described in detail in order to highlight the purport of the present invention.

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those of ordinary skill in the art. Unless otherwise specified, the units used in this specification are international standard units, and the numerical values ​​and numerical ranges appearing in the present invention should be understood to include inevitable systematic errors in industrial production. Unless otherwise specified, the experimental methods used in the following implementations are all conventional methods; the materials, reagents or instruments used without indicating the manufacturer are all reagents and materials available from commercial channels. Those without indicating specific conditions in the examples are all carried out according to conventional conditions or conditions recommended by the manufacturer. At the same time, the present invention does not limit the source of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all common commercial products in the field of this technology.

[0033] It should be noted that the raw material compositions used in the following examples are uniformly described in Table 1:

[0034] Table 1: Raw material composition (potassium chloride granules)

[0035] Name of raw materials and auxiliary materials Weight Potassium chloride 1350~1650 copies Sour flavoring agent 7-8 servings Colorants 3-6 servings Sweet flavoring agent 20~40 servings Glidants 5-15 servings essence 5-15 servings

[0036] In the above formula, the glidant can be selected from at least one of micro-powdered silica gel, talc, and polyethylene glycol 4000-6000; the colorant can be selected from at least one of FD&C Yellow #6 pigment (FD&C Yellow No. 6) and carmine pigment; the sour flavoring agent can be selected from at least one of anhydrous citric acid and fumaric acid; the sweet flavoring agent can be selected from at least one of sucralose, stevioside, saccharin sodium and aspartame; the flavor can be selected from at least one of orange flavor, strawberry flavor, banana flavor and mint flavor.

[0037] The specific preparation process of potassium chloride granules is as follows:

[0038] (1) Preparation of smooth potassium chloride granules: Take potassium chloride raw material and pass it through a swing granulator with a 12-16 mesh screen to granulate the needle-shaped or columnar potassium chloride into relatively large square crystals. The swing granulator is a conventional device in the prior art, and its screen is controlled at 12-16 mesh to obtain the potassium chloride square crystals required for the subsequent operation process.

[0039] Then, add the granulated potassium chloride prismatic crystals into a sugar coating machine, set the inlet air temperature at 60-70°C, the coating pan speed at 15-20 rpm and the spraying speed at 1-2 ml / min, spray 30%-40% of the weight of potassium chloride with purified water, and after spraying, maintain the coating pan speed and continue drying and spheronization for 120-160 minutes to make the potassium chloride prismatic crystals relatively smooth and round dry particles.

[0040] (2) Potassium chloride granules flavoring and coloring: Prepare a sweet flavoring agent into a solution with a concentration of 30% to 40% (w / v), add the sour flavoring agent and coloring agent, stir and dissolve, and obtain a flavoring agent and coloring agent solution. Continue to maintain the inlet air temperature, rotation speed and spraying speed of the coating pan in the previous step, continue to spray the flavoring agent and coloring agent solution, and dry it for 20 to 30 minutes after spraying;

[0041] (3) Fragrance and water sealing of potassium chloride granules: Take essence, sieve through 150-200 mesh, add it to the coating pot, and roll mix it at a speed of 15-20 rpm for 10-20 minutes. Then take micro powder silica gel, sieve through 150-200 mesh, continue to add it to the coating pot, and roll mix it at the same speed for 10-20 minutes to obtain potassium chloride granules.

[0042] (4) Inner packaging: The granules are packed into aluminum-plastic composite bags. Usually, the inner packaging specification of potassium chloride granules is 1.65g / bag.

[0043] Example 1

[0044] The formula composition is shown in Table 2. The potassium chloride granules of this embodiment are prepared according to the aforementioned process, and the specific process is as follows:

[0045] (1) Preparation of smooth potassium chloride granules: Take potassium chloride raw material, pass it through a 16-mesh sieve and granulate the needle-shaped or columnar potassium chloride into relatively large square crystals.

[0046] Then, add the granulated potassium chloride prismatic crystals into a sugar coating machine, set the inlet air temperature to 60°C, the coating pan speed to 15 rpm and the spray speed to 1 ml / min, spray in 30% of the weight of potassium chloride in purified water, and then continue drying and spheronization for 120 minutes to make the potassium chloride prismatic crystals into relatively smooth and round dry granules.

[0047] (2) Potassium chloride granules for flavoring and coloring: Prepare a 30% (w / v) solution of sucralose, add citric acid and FD&C Yellow #6 pigment, stir to dissolve, continue to maintain the inlet temperature, rotation speed and spray speed of the coating pan, continue to spray the sweetener pigment solution, and dry for 20 minutes after spraying;

[0048] (3) Potassium chloride granules: Take orange flavor essence, sieve it through 200 mesh, add it to the coating pot, and roll mix it at a speed of 15 rpm for 10 minutes. Then take micro powder silica gel, sieve it through 200 mesh, continue to add it to the coating pot, and roll mix it at the same speed for 10 minutes to obtain potassium chloride granules.

[0049] (4) Inner packaging: The granules are packed into aluminum-plastic composite bags. Usually, the inner packaging specification of potassium chloride granules is 1.65g / bag.

[0050] Example 2

[0051] The formula composition is shown in Table 2. The potassium chloride granules of this embodiment are prepared according to the aforementioned process, and the specific process is as follows:

[0052] (1) Preparation of smooth potassium chloride granules: Take potassium chloride raw material, pass it through a 12-mesh sieve and granulate the needle-shaped or columnar potassium chloride into relatively large square crystals.

[0053] Then, the granulated potassium chloride prismatic crystals were added into a sugar coating machine, the air inlet temperature was set at 70°C, the coating pan speed was set at 20 rpm and the spray speed was set at 2 ml / min, 40% of the weight of potassium chloride in purified water was sprayed in, and then the drying and spheronization was continued for 160 minutes to make the potassium chloride prismatic crystals into relatively smooth and round dry granules.

[0054] (2) Potassium chloride granules flavoring and coloring: Prepare a 40% (w / v) solution of sucralose, add citric acid and FD&C Yellow #6 pigment, stir to dissolve, continue to maintain the inlet temperature, rotation speed and spray speed of the coating pan, continue to spray the sweetener pigment solution, and dry for 30 minutes after spraying;

[0055] (3) Fragrance and sealing of potassium chloride granules: Take orange flavor essence, sieve through 150 mesh, add it to the coating pot, and roll mix at a speed of 20 rpm for 20 minutes. Then take micro powder silica gel, sieve through 150 mesh, continue to add it to the coating pot, and roll mix at the same speed for 20 minutes to obtain potassium chloride granules.

[0056] (4) Inner packaging: The granules are packed into aluminum-plastic composite bags. Usually, the inner packaging specification of potassium chloride granules is 1.65g / bag.

[0057] Example 3

[0058] The formula composition is shown in Table 2. The potassium chloride granules of this embodiment are prepared according to the aforementioned process, and the specific process is the same as that of Example 1.

[0059] Table 2: Formula composition of examples and comparative examples

[0060] Name of raw materials and auxiliary materials Example 1 (parts by weight) Example 2 (parts by weight) Example 3 (parts by weight) Potassium chloride 1500 copies 1350 copies 1650 copies Anhydrous citric acid 7.5 servings 7 servings 8 servings FD&C Yellow#6 pigment 4.5 servings 3 servings 6 servings Sucralose 30 servings 20 servings 40 servings Micro powder silica gel 10 servings 5 servings 15 servings Orange flavor 10 servings 5 servings 15 servings

[0061] Comparative Example 1:

[0062] This comparative example adopts the traditional method (but without adding a binder) to prepare potassium chloride particles. The prescription of this comparative example is shown in Example 1. The specific preparation process is as follows:

[0063] The potassium chloride raw material was crushed and passed through a 12-mesh sieve. 1 / 2 of the prescribed amount of potassium chloride, 45% of the prescribed amount of micro-powdered silica gel and the remaining prescribed amount of potassium chloride were added in sequence and mixed for 15 minutes. Then, the remaining prescribed amount of micro-powdered silica gel, anhydrous citric acid, sucralose, orange flavor, and FD&C Yellow #6 pigment were added and mixed for 25 minutes to obtain potassium chloride granules.

[0064] The preparation of potassium chloride granules according to the traditional method, but without the addition of any binder, results in unsatisfactory granule flowability, too wide particle size distribution and unsatisfactory hygroscopicity.

[0065] Comparative Example 2

[0066] This solution prepares potassium chloride granules without adding any adhesive substances (such as sucrose and povidone K30), and pre-treats the potassium chloride material, including swing granulation and water-spheronization. A large number of attempts were made before determining a new feasible technical solution.

[0067] The difference between this comparative example and Example 1 is that step (1) is: taking potassium chloride raw material, passing it through a 16-mesh sieve in an oscillating granulator, granulating the needle-shaped or columnar potassium chloride into relatively large prismatic crystals, and then using the prismatic crystals to carry out the subsequent preparation of steps (2) to (4) (same as Example 1) to obtain potassium chloride granules. In this comparative example, the flavor correction and coloring treatment is directly carried out on the potassium chloride prismatic crystals, and the step of water-moistening and spheronization is not included.

[0068] Comparative Example 3

[0069] The difference between this comparative example and Example 1 is that step (1) is to grind the potassium chloride raw material through a 12-mesh sieve without performing a swing granulation process, and then perform a water-spheronization process on the ground material as in Example 1. Next, potassium chloride granules are prepared in the manner of Example 1 (steps (2) to (4)).

[0070] Comparative Example 4

[0071] The difference between this comparative example and Example 1 is that the water spheronization method in step (1) is different: the spraying speed of purified water is 5 ml / min. The other steps are prepared in the same manner as in Example 1 to obtain potassium chloride particles.

[0072] Comparative Example 5

[0073] The difference between this comparative example and Example 1 is that the water spheronization method in step (1) is different: the amount of purified water used is 25% of the weight of potassium chloride. The other steps are prepared in the same manner as in Example 1 to obtain potassium chloride particles.

[0074] Comparative Example 6

[0075] The difference between this comparative example and Example 1 is that the water spheronization method in step (1) is different: the amount of purified water used is 45% of the weight of potassium chloride. The other steps are prepared in the same manner as in Example 1 to obtain potassium chloride particles.

[0076] Comparative Example 7

[0077] The difference between this comparative example and Example 1 is that the water-spheronization method in step (1) is different: after the purified water is sprayed, the drying and spheronization time is continued for 100 minutes. The other steps are prepared in the same manner as in Example 1 to obtain potassium chloride particles.

[0078] Comparative Example 8

[0079] The difference between this comparative example and Example 1 is that the water-spheronization method in step (1) is different: after the purified water is sprayed, the drying and spheronization time is continued for 180 minutes. The other steps are prepared in the same manner as in Example 1 to obtain potassium chloride particles.

[0080] Comparative Example 9

[0081] The difference between this comparative example and Example 1 is that no silica gel powder is added in step (3). The other steps are carried out in the same manner as in Example 1 to prepare potassium chloride particles.

[0082] Experimental Example 1

[0083] The potassium chloride particles obtained in the examples and comparative examples were subjected to performance tests, including: particle size distribution range, angle of repose (fluidity), color, moisture absorption rate, etc. The experimental results are detailed in Table 3. The angle of repose refers to the maximum angle of the natural slope that can be formed by freely stacked granular material without interference from external forces. The size of the angle of repose reflects the friction and adhesion between particles, and it is an important indicator for evaluating the fluidity of granular materials. A small angle of repose means that the friction between particles is small and the fluidity is good. A large angle of repose means that the friction between particles is large and the fluidity is poor. Materials with an angle of repose between 30° and 40° have good fluidity. Materials with an angle of repose greater than 40° have poor fluidity.

[0084] Table 3: Test results of potassium chloride particles prepared according to the examples and comparative examples

[0085]

[0086]

[0087] In the production process of granules, if a granular material with poor fluidity is used, the material flow is likely to be poor during the packaging process, and material accumulation occurs, resulting in too little loading in some small packages, too much loading in some small packages, and not meeting product requirements. In addition, materials with poor fluidity may cause blockage inside the production equipment or increase friction, which will aggravate the wear of machine parts over a long period of time, and increase maintenance frequency and cost. According to the experimental data of Table 1, the potassium chloride particles obtained according to the preparation method of Examples 1 to 3 have a narrow particle size distribution range, most of which are 12 mesh to 20 mesh, and the particle uniformity is relatively ideal. And the potassium chloride particles are all light yellow particles in appearance, with uniform color and luster, which meets the requirements. The repose angle of the particles is small, indicating that the fluidity of the potassium chloride particles is relatively good, and the transmission fluency is relatively ideal on the production line. In the process of potassium chloride particle packaging, good particle fluidity can not only ensure the packaging speed, but also ensure that it is not easy to produce dosage deviations during the packaging process.

[0088] Excessive humidity may cause the particles to clump or harden, affecting their solubility and ease of administration. Some active ingredients may undergo hydrolysis and other reactions in a humid environment, resulting in reduced efficacy or even failure. High humidity is conducive to the growth of bacteria and mold, increasing the risk of drug contamination. The above experimental results show that the potassium chloride particles obtained according to the preparation method of Examples 1 to 3 also have the advantage of low moisture absorption. The new preparation process provided in this scheme can avoid the negative impact caused by the excessive hygroscopicity of the particles.

[0089] In Comparative Example 1, the traditional method for preparing potassium chloride granules was adopted, except that no binder was introduced into the traditional method. The results showed that the uniformity of the particles of the product was not ideal, with only about 65% of the particles having a size of 12 to 20 mesh, and the rest being particles that were too large or too small. Although a micropowdered silica gel flow aid was added to Comparative Example 1, the fluidity of the particles was still not ideal, with an angle of repose of up to 41.2°, and there were differences in color between the particles, with uneven distribution of the colorant. Furthermore, since no binder or other materials were added, the hygroscopicity of the particles was relatively high. It can be seen that the technical solution overcomes the shortcomings of the traditional method due to the lack of a binder by means of granulation by a swing granulator and water-spheronization.

[0090] In Comparative Example 2, only the swing granulator was used to process the potassium chloride raw material, and the water-spheronization step using water was not performed. As a result, it was found that the uniformity of the product particles was not ideal, the fluidity was not ideal, the particles had color differences, and the particles had high hygroscopicity. This shows that the water-spheronization step plays a relatively important role in improving the quality of the finished product of potassium chloride particles.

[0091] In Comparative Example 3, before the water-spheronization treatment, no swing granulation treatment was performed and potassium chloride prismatic crystals were not formed. As a result, it was found that the uniformity of the product particles was not ideal, the fluidity was not ideal, the particles had color differences, and the particles had high hygroscopicity. This shows that the swing finishing treatment step plays a relatively important role in improving the quality of the finished product of potassium chloride particles. The swing finishing treatment step and the water-spheronization treatment step need to be performed successively to overcome the defects in the particle uniformity, hygroscopicity and fluidity of the product caused by the lack of an adhesive.

[0092] In Comparative Example 4, in the water spheronization step, the spraying speed of purified water was increased to 5 ml / min, which had a certain effect on the uniformity of the particles compared with Example 1, but it was not very significant. It had a greater impact on the fluidity of the particles, resulting in less than ideal fluidity of the particles and uneven color of the particles, but did not have a significant impact on the hygroscopicity of the particles.

[0093] In Comparative Example 5, in the water-spheronization step, the amount of purified water used is 25% of the weight of potassium chloride, which is relatively small, and has a certain negative impact on the uniformity and fluidity of the particles, but has no significant negative impact on the color distribution and hygroscopicity.

[0094] In Comparative Example 6, in the water-spheronization step, the amount of purified water used was 45% of the weight of potassium chloride, which was relatively large and had no significant negative impact on the uniformity, fluidity, color distribution and hygroscopicity of the particles.

[0095] In comparative example 7, after the purified water was sprayed, the drying and spheronization was continued for 100 minutes, and the treatment time was relatively short. This treatment method would reduce the uniformity of the particle size to a certain extent, and the particles were easy to agglomerate.

[0096] In Comparative Example 8, after the purified water was sprayed, the drying and spheronization was continued for 180 minutes, and the treatment time was relatively long. This treatment method would reduce the uniformity of particle size to a certain extent, and the particle fluidity would be relatively poor.

[0097] In Comparative Example 9, micro-powder silica gel was not added, which affected the fluidity of the particles. The potassium chloride particles obtained were relatively large, with particles between 12 mesh and 20 mesh accounting for only about 65%, and the particle size distribution was uneven. In addition, the absence of micro-powder silica gel resulted in strong hygroscopicity of the particles.

[0098] In summary, the technical solution achieves the purpose of increasing the fluidity, uniformity of size and color of the particles, reducing hygroscopicity, further improving product quality, and avoiding the introduction of too many auxiliary materials without adding adhesives. The optimal process conditions of this solution are: first use a swing granulator with a 12-16 mesh sieve to process the potassium chloride raw material to obtain potassium chloride prisms; then, water-moistened and spheronized to obtain smooth potassium chloride particles; during the water-moistened and spheronized process, the liquid spray rate is 1-2 ml / min, 30%-40% of the weight of potassium chloride is sprayed with water, and then the drying and spheronization is continued for 120-160 minutes to obtain smooth potassium chloride particles. This technical solution uses an existing coating machine to replace the coating liquid with purified water, and water-moistened and spheronized potassium chloride to improve the fluidity and particle uniformity of potassium chloride particles and reduce the hygroscopicity of the particles.

[0099] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. An industrial process for producing potassium chloride granule composition particles, characterized in that: The method includes the following steps in sequence: S1 Preparation of smooth potassium chloride granules: subjecting the potassium chloride raw material to a swing granulation process to obtain potassium chloride prismatic crystals; subjecting the potassium chloride prismatic crystals to a water-spheronization process to obtain smooth potassium chloride granules; S2 Potassium chloride granules flavoring and coloring: Use a coating solution containing flavoring agents and coloring agents to coat the smooth potassium chloride granules to obtain flavoring and coloring potassium chloride granules; S3 Potassium Chloride Granules Fragrance and Water Sealing: The flavored and colored potassium chloride granules are sequentially mixed with flavoring agents and flow aids to obtain finished potassium chloride granules.

2. The industrialization process of a potassium chloride granule composition particle according to claim 1, characterized in that: In S1, the sieve for swing granulation uses a 12-16 mesh sieve.

3. The industrialization process of a potassium chloride granule composition particle according to claim 2, characterized in that: In S1, the method of using water to moisten and spheronize potassium chloride prismatic crystals is as follows: adding potassium chloride prismatic crystals into a sugar coating machine, setting the air inlet temperature to 60-70°C, the coating pan speed to 15-20 rpm, and the spraying speed to 1-2 ml / min, spraying water, and then continuing to dry and spheronize to obtain smooth potassium chloride particles.

4. The industrialization process of a potassium chloride granule composition granule according to claim 3, characterized in that: In S1, the amount of water used is 30% to 40% of the weight of potassium chloride.

5. The industrialization process of a potassium chloride granule composition granule according to claim 4, characterized in that: In S1, the drying and spheronization time is 120 to 160 minutes.

6. The industrialization process of a potassium chloride granule composition granule according to claim 1, characterized in that: In S2, the coating solution containing a flavoring agent and a coloring agent is used to coat the potassium chloride smooth granules in the following manner: a sweet flavoring agent is prepared into a solution with a concentration of 30% to 40% (w / v), and then a sour flavoring agent and a coloring agent are added, and the flavoring agent and coloring agent are obtained after stirring and dissolving; Set the air inlet temperature to 60-70°C, the coating pan speed to 15-20 rpm and the liquid spraying speed to 1-2 ml / min, spray the flavoring agent and pigment solution, and then dry for 20-30 minutes.

7. The industrialization process of a potassium chloride granule composition granule according to claim 1, characterized in that: In S3, the flavor and the flow aid are passed through a 150-200 mesh sieve and then mixed with the flavored and colored potassium chloride granules; The mixing speed is 15 to 20 rpm, and the mixing time is 10 to 20 minutes.

8. Potassium chloride granules prepared by the industrialization process of a potassium chloride granule composition granule according to any one of claims 1 to 7.

9. The potassium chloride granules prepared by the industrialization process of the potassium chloride granule composition granules according to claim 8, characterized in that: Calculated by weight, the raw materials include 1350-1650 parts of potassium chloride, 7-8 parts of sour flavoring agent, 3-6 parts of coloring agent, 20-40 parts of sweet flavoring agent, 5-15 parts of flow aid and 5-15 parts of flavor.

10. The potassium chloride granules prepared by the industrialization process of the potassium chloride granule composition granules according to claim 9, characterized in that: The glidant includes at least one of micro powder silica gel, talcum powder, and polyethylene glycol 4000-6000; The colorant includes at least one of FD&C Yellow #6 pigment and carmine pigment; The sour flavoring agent includes at least one of anhydrous citric acid and fumaric acid; The sweet flavoring agent includes at least one sweetener selected from sucralose, steviol glycoside, saccharin sodium and aspartame; The flavor includes at least one of orange flavor, strawberry flavor, banana flavor and mint flavor.

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