Preparation method of inosine tablets

Abstract

The invention discloses a preparation method of inosine tablets, and belongs to the technical field of inosine tablet preparation, inosine, a filler, a disintegrating agent and a lubricant are included, the preparation method of the inosine tablets comprises the following steps: raw material preparation: inosine is prepared as a main material, the filler is starch and dextrin, the disintegrating agent is sodium carboxymethyl starch, and the lubricant is magnesium stearate; the preparation method comprises the following steps: adding starch into powdered sugar, then adding purified water, and uniformly mixing and stirring in a water bath environment to obtain gelatinized starch slurry as an adhesive solution for later use; the inosine raw material, starch and dextrin are put into a mixer to be mixed according to the proportion of the inosine raw material to the starch to the dextrin being 7: 2: 1, sodium carboxymethyl starch is adopted as a disintegrating agent, the tablet can rapidly absorb water to swell after encountering water, the tablet is disintegrated, medicine dissolution is promoted, a lubricating agent magnesium stearate is added, and the effect is good. Friction force of tablets in the tabletting process can be reduced, sticking of the tablets is prevented, and smooth surfaces of the tablets are guaranteed.

Description

Technical Field

[0001] The invention relates to the technical field of inosine tablet preparation, in particular to a method for preparing inosine tablets. Background Art

[0002] Inosine tablets are a pharmaceutical preparation with inosine as the main ingredient. Inosine plays an important physiological function in the body. It can directly penetrate the cell membrane into the body cells and activate pyruvate oxidase. Pyruvate oxidase is crucial in the energy metabolism of cells and participates in the tricarboxylic acid cycle, which is a key metabolic pathway for cells to produce energy (ATP). When the body's tissue cells are in a low-energy hypoxic state, such as myocardial cells in myocardial ischemia or liver cells in disease states such as hepatitis, inosine can help these cells better utilize energy, maintain the basic metabolic functions of cells, and promote cell repair and regeneration. From the perspective of the prior art, the common inosine tablets, the dosage form itself may limit the dissolution rate of the drug. Compared with dosage forms such as solution, inosine tablets need to disintegrate first after taking, so that the drug decomposes slowly in the body, resulting in insufficient drug dissolution, affecting the absorption and efficacy of the drug. The few inosine tablets containing disintegrating elements have an inappropriate disintegration rate, either too slow or too fast, causing the drug to fail to reach the effective position for disintegration and release. For this reason, we provide a method for preparing inosine tablets. Summary of the invention

[0003] The purpose of the present invention is to provide a method for preparing inosine tablets in view of the above technical problems, which has the advantages of being able to rapidly absorb water and swell after the tablets come into contact with water, causing the tablets to disintegrate, promoting the dissolution of the drug, reducing the friction of the tablets during the tableting process, preventing the tablets from sticking, and ensuring a smooth tablet surface.

[0004] To achieve this object, the present invention provides a method for preparing an inosine tablet, which adopts the following technical embodiments:

[0005] A method for preparing an inosine tablet comprises inosine, a filler, a disintegrant and a lubricant. The method for preparing the inosine tablet comprises the following steps:

[0006] S1: Raw material preparation, inosine as the main ingredient, starch and dextrin as fillers, sodium carboxymethyl starch as disintegrant, and magnesium stearate as lubricant;

[0007] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for later use;

[0008] S3: Mixing: putting the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material and mixing them;

[0009] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material;

[0010] S5: The soft material is made into wet granules by a swing granulator;

[0011] S6: Place the wet granules in an oven for drying to avoid excessive temperature causing inosine decomposition. During the drying process, pay attention to turning the granules to ensure that the granules are dried evenly and the drying is complete;

[0012] S7: The granules after drying may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting;

[0013] S8: putting the granulated particles, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the particles;

[0014] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0015] Preferably, in step S1, the content of the disintegrant is 2%-6%, the content of the lubricant is 0.25%-1%, the content of the filler is 20%-28%, and the content of inosine is 65%-69%.

[0016] Preferably, in step S2, the concentration of the adhesive solution is 5%-10%.

[0017] Preferably, in step S3, the mixing time of the mixer is 15-30 minutes and the rotation speed is 10-20 rpm.

[0018] Preferably, in step S4, the ratio of the mixed material to the adhesive solution is 5:1.

[0019] Preferably, in step S5, the mesh size of the granulator is 14-20 meshes.

[0020] Preferably, in step S6, the drying temperature is controlled at 50-60°C, and the drying is completed after the moisture content of the particles is 2%-3%.

[0021] Preferably, in step S7, the mesh size of the granulator can be selected to be 16-20 meshes.

[0022] Preferably, in step S8, the total mixing time is 10-15 minutes, and the rotation speed is 10-15 rpm.

[0023] minute.

[0024] Preferably, in step S9, each tablet contains 0.2g±5% inosine, and the hardness of the inosine tablet is 3-5kg / cm2 .

[0025] The present invention has at least the following beneficial effects:

[0026] In the present invention, inosine can directly penetrate the cell membrane into the body cells and activate pyruvate oxidase. Pyruvate oxidase plays a key role in the energy metabolism of cells and can promote protein synthesis. In the treatment of various acute and chronic hepatitis, inosine tablets can be used as an auxiliary drug. It helps to improve liver function and reduce liver inflammatory response;

[0027] In the present invention, starch and dextrin are used as fillers, which are relatively cheap and have good compressibility and fluidity, and are helpful for tablet molding. Dextrin is a product of starch hydrolysis, which can increase the viscosity of the tablet and make the tablet more compact;

[0028] In the present invention, sodium carboxymethyl starch is used as a disintegrant, which can rapidly absorb water and swell the tablet after it meets water, so that the tablet disintegrates and the dissolution of the drug is promoted. The lubricant magnesium stearate is added to reduce the friction of the tablet during the tableting process, prevent the tablet from sticking, and ensure that the tablet surface is smooth.

[0029] In the present invention, an adhesive solution is added to the inosine tablets to form an adhesive layer on the surface of the material particles, which can fill the gaps between the material particles, connect the particles to each other, and enhance the forming rate of the particles. During the granulation process, the adhesive can increase the strength of the particles. Sufficient adhesive can form a skeleton-like structure inside the particles, so that the particles can remain intact during subsequent drying, granulation and tableting processes.

[0030] Other advantages, objectives and features of the present invention will be embodied in part through the following description, and in part will be understood by those skilled in the art through study and practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 The figure is a relationship diagram between the weight of the inosine tablet and the water dissolution time in Example 1 of the method for preparing the inosine tablet of the present invention;

[0032] Figure 2 This is a graph showing the relationship between the weight of an inosine tablet and the water dissolution time in Example 2 of a method for preparing an inosine tablet of the present invention;

[0033] Figure 3 This is a relationship diagram of the weight of inosine tablets and the water dissolution time in Example 3 of the method for preparing inosine tablets of the present invention;

[0034] Figure 4 This is a graph showing the relationship between the weight of inosine tablets and the water dissolution time in Example 4 of a method for preparing inosine tablets of the present invention;

[0035] Figure 5 This is a graph showing the relationship between the weight of inosine tablets and the water dissolution time in Example 5 of the method for preparing inosine tablets of the present invention. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical embodiments and advantages of the present invention more clear, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0037] The application principle of the present invention is described in detail below in conjunction with the accompanying drawings.

[0038] A method for preparing an inosine tablet comprises inosine, a filler, a disintegrant and a lubricant. The method for preparing the inosine tablet comprises the following steps:

[0039] S1: Raw material preparation, inosine as the main ingredient, starch and dextrin as fillers, sodium carboxymethyl starch as disintegrant, and magnesium stearate as lubricant;

[0040] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix well.

[0041] The obtained gelatinized starch slurry is used as an adhesive solution for later use;

[0042] S3: Mixing: putting the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material and mixing them;

[0043] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material;

[0044] S5: The soft material is made into wet granules by a swing granulator;

[0045] S6: Place the wet granules in an oven for drying to avoid excessive temperature causing inosine decomposition. During the drying process, pay attention to turning the granules to ensure that the granules are dried evenly and the drying is complete;

[0046] S7: The granules after drying may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting;

[0047] S8: putting the granulated particles, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the particles;

[0048] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0049] Wherein, in step S1, the content of disintegrant is 2%-6%, the content of lubricant is 0.25%-1%, the content of filler is 20%-28%, and the content of inosine is 65%-69%.

[0050] Wherein, in step S2, the concentration of the adhesive solution is 5%-10%.

[0051] In step S3, the mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm.

[0052] minute.

[0053] Wherein, in step S4, the ratio of the mixed material to the adhesive solution is 5:1.

[0054] Wherein, in step S5, the mesh size of the granulator is 14-20 meshes.

[0055] In step S6, the drying temperature is controlled at 50-60°C and the moisture content of the particles is controlled at 2%-3%.

[0056] After that, the drying is completed.

[0057] Wherein, in step S7, the mesh size of the granulator can be selected to be 16-20 meshes.

[0058] Wherein, in step S8, the total mixing time is 10-15 minutes, and the rotation speed is 10-15 rpm.

[0059] Wherein, in step S9, each tablet contains 0.2g±5% inosine, and the hardness of the inosine tablet is 3-5kg / cm 2 .

[0060] Example 1

[0061] The preparation method of inosine tablets in this embodiment is as follows:

[0062] S1: Raw material preparation, preparing inosine as the main material, the content of disintegrant is 6%, the content of lubricant is 1%, the content of filler is 25%, and the content of inosine is 68%;

[0063] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for standby use, and the concentration of the adhesive solution is 5%-10%;

[0064] S3: Mixing: Put the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material, and mix them. The mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm;

[0065] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material, wherein the ratio of the mixed material to the adhesive solution is 5:1;

[0066] S5: The soft material is made into wet granules by a swing granulator, and the mesh number of the granulator is 14-20 mesh;

[0067] S6: Put the wet granules into the oven for drying to avoid excessive temperature causing decomposition of inosine. During the drying process, pay attention to turning the granules to make the granules dry evenly. After the drying is completed, the drying temperature is controlled at 50-60°C. After the moisture content of the granules is 2%-3%, the drying is completed;

[0068] S7: The dried granules may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting. In step S7, the mesh size of the granulator can be selected to be 16-20 meshes;

[0069] S8: putting the granules after granulation, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the granules, the total mixing time is 10-15 minutes, and the speed is 10-15 rpm;

[0070] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0071] The inosine tablets prepared in this example and the water solubility curve are as follows: Figure 1 shown.

[0072] Example 2

[0073] The preparation method of inosine tablets in this embodiment is as follows:

[0074] S1: Raw material preparation, preparing inosine as the main material, the content of lubricant is 1%, the content of filler is 25%, and the content of inosine is 74%;

[0075] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for standby use, and the concentration of the adhesive solution is 5%-10%;

[0076] S3: Mixing: Put the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material, and mix them. The mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm;

[0077] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material, wherein the ratio of the mixed material to the adhesive solution is 5:1;

[0078] S5: The soft material is made into wet granules by a swing granulator, and the mesh number of the granulator is 14-20 mesh;

[0079] S6: Put the wet granules into the oven for drying to avoid excessive temperature causing decomposition of inosine. During the drying process, pay attention to turning the granules to make the granules dry evenly. After the drying is completed, the drying temperature is controlled at 50-60°C. After the moisture content of the granules is 2%-3%, the drying is completed;

[0080] S7: The dried granules may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting. In step S7, the mesh size of the granulator can be selected to be 16-20 meshes;

[0081] S8: Put the granulated particles and lubricant into a mixer for total mixing, ensuring that the lubricant is evenly distributed on the surface of the particles. The total mixing time is 10-15 minutes and the speed is 10-15 rpm;

[0082] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0083] The dissolution of the inosine tablets prepared in this example was compared with that of the inosine tablets prepared in Example 1. Figure 2 shown.

[0084] Example 3

[0085] The preparation method of inosine tablets in this embodiment is as follows:

[0086] S1: Raw material preparation, preparing inosine as the main material, the content of disintegrant is 1%, the content of lubricant is 1%, the content of filler is 25%, and the content of inosine is 68%;

[0087] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for standby use, and the concentration of the adhesive solution is 5%-10%;

[0088] S3: Mixing: Put the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material, and mix them. The mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm;

[0089] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material, wherein the ratio of the mixed material to the adhesive solution is 5:1;

[0090] S5: The soft material is made into wet granules by a swing granulator, and the mesh number of the granulator is 14-20 mesh;

[0091] S6: Put the wet granules into the oven for drying to avoid excessive temperature causing decomposition of inosine. During the drying process, pay attention to turning the granules to make the granules dry evenly. After the drying is completed, the drying temperature is controlled at 50-60°C. After the moisture content of the granules is 2%-3%, the drying is completed;

[0092] S7: The dried granules may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting. In step S7, the mesh size of the granulator can be selected to be 16-20 meshes;

[0093] S8: putting the granules after granulation, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the granules, the total mixing time is 10-15 minutes, and the speed is 10-15 rpm;

[0094] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0095] The battery was subjected to gram capacity and cycle tests at a test temperature of 25°C and a test voltage range of 2.8 to 4.4V. Example 1, Example 2 and Example 3 were connected to a charging cabinet, first charged to 4.4V with a 0.1C constant current, then charged to full charge at a constant voltage, and the gram capacity data was recorded. After standing for 5 minutes, the battery was charged to 4.4V with a 0.2C constant current, then charged at a constant voltage, and discharged at 0.5C after standing for 5 minutes until the cycle capacity retention rate of the cycled battery was less than 80%. The battery cycle test was completed. The test results are as follows: Figure 3 shown.

[0096] The dissolution of the inosine tablets prepared in this example is compared with that of the inosine tablets prepared in Example 1 and Example 2. Figure 3 shown.

[0097] Example 4

[0098] The preparation method of inosine tablets in this embodiment is as follows:

[0099] S1: Raw material preparation, preparing inosine as the main material, the content of disintegrant is 3%, the content of lubricant is 1%, the content of filler is 25%, and the content of inosine is 66%;

[0100] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for standby use, and the concentration of the adhesive solution is 5%-10%;

[0101] S3: Mixing: Put the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material, and mix them. The mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm;

[0102] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material, wherein the ratio of the mixed material to the adhesive solution is 5:1;

[0103] S5: The soft material is made into wet granules by a swing granulator, and the mesh number of the granulator is 14-20 mesh;

[0104] S6: Put the wet granules into the oven for drying to avoid excessive temperature causing decomposition of inosine. During the drying process, pay attention to turning the granules to make the granules dry evenly. After the drying is completed, the drying temperature is controlled at 50-60°C. After the moisture content of the granules is 2%-3%, the drying is completed;

[0105] S7: The dried granules may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting. In step S7, the mesh size of the granulator can be selected to be 16-20 meshes;

[0106] S8: putting the granules after granulation, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the granules, the total mixing time is 10-15 minutes, and the speed is 10-15 rpm;

[0107] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0108] The dissolution of the inosine tablets prepared in this example is compared with that of the inosine tablets prepared in Example 1, Example 2, and Example 3. Figure 4 shown.

[0109] Example 5

[0110] The preparation method of inosine tablets in this embodiment is as follows:

[0111] S1: Raw material preparation, preparing inosine as the main material, the content of disintegrant is 7%, the content of lubricant is 1%, the content of filler is 25%, and the content of inosine is 65%;

[0112] S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for standby use, and the concentration of the adhesive solution is 5%-10%;

[0113] S3: Mixing: Put the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material, and mix them. The mixing time of the mixer is 15-30 minutes, and the speed is 10-20 rpm;

[0114] S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material, wherein the ratio of the mixed material to the adhesive solution is 5:1;

[0115] S5: The soft material is made into wet granules by a swing granulator, and the mesh number of the granulator is 14-20 mesh;

[0116] S6: Put the wet granules into the oven for drying to avoid excessive temperature causing decomposition of inosine. During the drying process, pay attention to turning the granules to make the granules dry evenly. After the drying is completed, the drying temperature is controlled at 50-60°C. After the moisture content of the granules is 2%-3%, the drying is completed;

[0117] S7: The dried granules may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting. In step S7, the mesh size of the granulator can be selected to be 16-20 meshes;

[0118] S8: putting the granules after granulation, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the granules, the total mixing time is 10-15 minutes, and the speed is 10-15 rpm;

[0119] S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

[0120] The dissolution of the inosine tablets prepared in this example is compared with that of the inosine tablets prepared in Examples 1, 2, 3, and 4. Figure 5 shown.

[0121] By comparing Examples 1-5, it can be seen that the inosine tablets containing disintegrants have a high dissolution rate, and in the process of comparing Examples 1-4, it is found that the greater the content of disintegrants, the faster the dissolution rate, and there are no other adverse reactions, and the efficacy is not affected. The content of 6% of disintegrant in Example 1 is most suitable; compared with Example 1 and Example 5, the dissolution rate of Example 5 is higher than that of Example 1, but the inosine tablets dissolve too quickly, and a large amount of release begins in the oral cavity and esophagus. On the one hand, it may cause excessive local drug concentration, produce a bad taste, and excessive bitterness, which will irritate the oral and esophageal mucosa and cause discomfort; on the other hand, too fast disintegration causes the drug to be unable to be effectively absorbed at the best absorption site. In comparison, the scheme of Example 1 is the most reasonable.

[0122] The above embodiments are only used to illustrate rather than limit the technical embodiments of the present invention. Relevant technical personnel in the field may make reasonable modifications or equivalent substitutions to the present invention, but any modifications and partial substitutions that do not depart from the spirit and scope of the present invention should be included in the scope of the claims of the present invention.

[0123] The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in this field.

Claims

1. A method for preparing inosine tablets, comprising inosine, a filler, a disintegrant and a lubricant, characterized in that: The preparation method of the inosine tablet comprises the following steps: S1: Raw material preparation, inosine as the main ingredient, starch and dextrin as fillers, sodium carboxymethyl starch as disintegrant, and magnesium stearate as lubricant; S2: Add starch to powdered sugar and then to purified water, place in a water bath and mix and stir evenly to obtain gelatinized starch slurry as an adhesive solution for later use; S3: Mixing: putting the inosine raw material, starch and dextrin into a mixer in a ratio of 7:2:1 of the inosine raw material and mixing them; S4: adding the adhesive solution in step S2 to the uniformly mixed material, stirring while adding, to prepare a soft material; S5: The soft material is made into wet granules by a swing granulator; S6: Place the wet granules in an oven for drying to avoid excessive temperature causing inosine decomposition. During the drying process, pay attention to turning the granules to ensure that the granules are dried evenly and the drying is complete; S7: The granules after drying may be partially agglomerated and need to be granulated by a granulator to make the granules more uniform in size for tableting; S8: putting the granulated particles, disintegrant and lubricant into a mixer for total mixing, ensuring that the disintegrant and lubricant are evenly distributed on the surface of the particles; S9: Use a rotary tablet press or a single punch tablet press to compress the tablets, adjusting the pressure and punch size according to the weight.

2. The method for preparing an inosine tablet according to claim 1, characterized in that: In the step S1, the content of the disintegrant is 2%-6%, the content of the lubricant is 0.25%-1%, the content of the filler is 20%-28%, and the content of inosine is 65%-69%.

3. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S2, the concentration of the adhesive solution is 5%-10%.

4. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S3, the mixing time of the mixer is 15-30 minutes, and the rotation speed is 10-20 rpm.

5. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S4, the ratio of the mixed material to the adhesive solution is 5:

1.

6. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S5, the mesh size of the granulator is 14-20 meshes.

7. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S6, the drying temperature is controlled at 50-60°C, and the drying is completed after the moisture content of the particles is 2%-3%.

8. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S7, the mesh size of the granulator can be selected to be 16-20 meshes.

9. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S8, the total mixing time is 10-15 minutes, and the rotation speed is 10-15 rpm.

10. The method for preparing an inosine tablet according to claim 1, characterized in that: In step S9, each tablet contains 0.2g±5% of inosine, and the hardness of the inosine tablet is 3-5kg / cm 2 .

Images