Preparation process and application of instant donkey-hide gelatin granules

Abstract

The invention discloses a preparation process of instant donkey-hide gelatin granules. The preparation process comprises the following steps: preparing donkey-hide gelatin powder; preparing an adhesive from donkey-hide gelatin powder, hydroxypropyl methyl cellulose, sucrose ester-13 and water; putting the rubber powder into a raw material container of a boiling granulator for granulating; drying the granules in a microwave drying oven; and drying the granules in an infrared electric heating drying box, and spraying a coating agent solution for coating to obtain the instant donkey-hide gelatin granules. Through boiling granulation, a solid dispersion technology and a particle coating and microwave drying technology, the problems that instant donkey-hide gelatin particles are prone to caking, poor in dissolubility and poor in taste are solved, meanwhile, the smell of donkey-hide gelatin is reduced and the solubility is improved through selection of a coating agent, and the instant donkey-hide gelatin particles prepared through the technology reduce the dryness of donkey-hide gelatin, so that the quality of the donkey-hide gelatin particles is improved. Internal heat caused by long-term use of colla corii asini is effectively prevented, the content of volatile alkaline substances in the product is reduced, the stability is improved, and the product quality is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medicines, and in particular to a preparation process and application of instant donkey-hide gelatin granules. Background Art

[0002] Donkey-hide gelatin is a block of gelatin made by dehairing the skin of donkeys, an equine animal. It is composed of the hydrolysis products of collagen and other substances, so its main component is protein. Clinically, donkey-hide gelatin is often used to treat blood deficiency and sallow complexion, coughing and hemoptysis due to fatigue, vomiting blood, blood in stool and metrorrhagia, etc. In addition, donkey-hide gelatin can also be used in the food field. It is a very good nourishing product, and it has appeared in various dosage forms such as oral liquid and granules. The traditional dosage form of donkey-hide gelatin is a brown and hard gelatin plate. When taking it, it needs to be smashed and boiled with water or melted in water in a steamer and then taken while hot, which brings great inconvenience to the user. In addition, when traditional donkey-hide gelatin powder is mixed with hot water, it dissolves slowly, is easy to clump, has low dispersibility, poor solubility, and poor sensory quality.

[0003] In clinical applications, donkey-hide gelatin is often melted after processing. The traditional method is frying, and modern methods include baking, vacuum, microwave, etc. In this study, instant donkey-hide gelatin powder was prepared by boiling granulation technology to solve the problems of difficult processing of donkey-hide gelatin and poor solubility of donkey-hide gelatin powder, and overcome the greasy nature of raw donkey-hide gelatin; boiling granulation, microwave pre-drying and infrared drying technology were used to shape it, and a high-efficiency disintegrant was added to make it a kind of instant granules, solving the problems of easy agglomeration, poor solubility and greasy taste of donkey-hide gelatin powder. Summary of the invention

[0004] In order to solve the problems of easy agglomeration, poor solubility and greasy taste of instant donkey-hide gelatin granules, the present invention establishes a preparation process of instant donkey-hide gelatin granules, which adopts boiling granulation, solid dispersion, microwave pre-drying and infrared drying technology in combination, so that the donkey-hide gelatin granules can be instantized, and the taste, stability and product quality can be improved.

[0005] In order to achieve the above object, the technical solution of the present invention is:

[0006] The present invention provides a preparation process of instant donkey-hide gelatin granules, comprising the following steps:

[0007] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0008] 2. Preparation of adhesive: Mix donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water according to 1:

[0009] The adhesive is prepared in a ratio of 1.8-2.2:2.7-3.3:38-42;

[0010] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2-3% of the weight of the glue into the infusion tank, spray pressure 0.25-0.35MPa, auxiliary spray pressure 0.05-0.2Mpa, negative pressure 2000-6000pa, the standard for making granules is that the sum of the particles and powder that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0011] 4. Microwave drying: Place the above particles in a microwave drying oven with a power of 600-800KW and dry for 10-20 minutes;

[0012] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 60℃-80℃ for 1-2 hours;

[0013] 6. Coating: After granulation, place the granules in an automatic coating machine, and spray 70% ethanol solution of 1.5%-1.6% hydroxypropyl methylcellulose and 0.5%-0.6% polyethylene glycol as a coating solution in a mass ratio of 1:0.8-1.2 for donkey-hide gelatin granules to coating solution for coating.

[0014] Furthermore, the donkey-hide gelatin particles also include a flavoring agent. The flavoring agent is monellin. By selecting the flavoring agent, the taste of the donkey-hide gelatin particles can be better improved.

[0015] The beneficial effects of the present invention are:

[0016] The invention provides a preparation process of instant donkey-hide gelatin particles. The invention solves the problems of easy agglomeration, poor solubility and poor taste of instant donkey-hide gelatin particles through boiling granulation, solid dispersion technology, particle coating and microwave drying technology. At the same time, the odor of donkey-hide gelatin is reduced and the solubility is improved through the selection of coating agent. The instant donkey-hide gelatin particles prepared by the process have reduced dryness of donkey-hide gelatin itself, effectively preventing internal heat caused by long-term use of donkey-hide gelatin, and at the same time reduce the content of volatile alkaline substances in the product, improve stability and enhance product quality. DETAILED DESCRIPTION

[0017] In order to enable those skilled in the art to more clearly understand the technical solution of the present invention, the technical solution of the present invention will be described in detail below in conjunction with specific embodiments.

[0018] The instant donkey-hide gelatin granules and their preparation method disclose the preparation method of instant donkey-hide gelatin granules (original process):

[0019] (1) Preparation of gelatin powder: Grind the donkey-hide gelatin block into fine powder with a particle size of 80-120 mesh;

[0020] (2) Preparation of adhesive: Prepare adhesive by mixing donkey-hide gelatin powder and water in a ratio of 1:40;

[0021] (3) Boiling granulation: Put the donkey-hide gelatin powder into the raw material container of the boiling granulator, add 2-3% (2% in the experimental example) of the weight of the donkey-hide gelatin as the binder for boiling granulation, the spray pressure is 0.25-0.35Mpa (0.25Mpa in the experimental example), the auxiliary spray pressure is 0.05-0.2Mpa (0.05Mpa in the experimental example), and the negative pressure is 2000-6000pa (2000pa in the experimental example). The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0022] (4) Drying: Place the qualified granules in an oven at 105°C for drying and sterilization until the moisture content does not exceed 5%.

[0023] In order to better judge the quality of the production process of instant donkey-hide gelatin granules, the scoring criteria for instant donkey-hide gelatin granules are determined as follows.

[0024] Table 1 Rating criteria for instant donkey-hide gelatin granules

[0025]

[0026]

[0027] Experimental Example 1: Preparation and Investigation of Adhesive

[0028] In order to ensure the uniform particle size of instant donkey-hide gelatin granules, the adhesive was investigated.

[0029] Table 2 Adhesive Comparison Experiment

[0030]

[0031] Table 3 Properties of donkey-hide gelatin particles prepared in Experimental Example 1

[0032]

[0033]

[0034] The experimental results show that the use of other adhesives can improve the properties of instant donkey-hide gelatin granules, but the content of volatile alkaline substances increases and approaches the limit, which may pose a risk of unqualified products. Therefore, process improvements are needed to avoid unqualified products.

[0035] Experimental Example 2 Investigation of Drying Methods

[0036] The drying method affects the final uniformity of instant donkey-hide gelatin granules and may affect the content of volatile alkaline substances. Therefore, the effects of different drying methods on the preparation were investigated.

[0037] Table 4 Comparison of blast drying, microwave drying and reduced pressure drying

[0038]

[0039]

[0040] Table 5 Comparison of donkey-hide gelatin particles prepared in Experimental Example 2

[0041] Serial number granularity Color Solubility Taste 01 81.2±3.7 59.4±3.9 78.6±5.4 56.6±3.1 02 82.2±4.0 58.4±3.4 79.4±4.7 55.2±3.5 03 85.6±3.9 77.6±4.3 87.6±3.6 55.9±3.3 04 86.7±3.5 76.9±3.5 84.2±2.3 57.8±2.7 05 90.2±2.8 82.9±2.7 90.5±1.7 58.2±1.6

[0042] Experimental Example 3 Screening of flavor correctives

[0043] In the above experimental results, the scores of taste indexes were not high, so the effect of flavoring agents on the final taste of the preparation was examined.

[0044] Table 6 Flavoring agent screening comparison

[0045]

[0046] Table 7 Properties of donkey-hide gelatin particles prepared in Experimental Example 3

[0047] Serial number granularity Color Solubility Taste 01 90.2±2.8 82.9±2.7 90.5±1.7 58.2±1.6 02 89.5±3.4 83.4±3.5 90.1±2.5 70.3±2.9 03 91.3±3.0 81.5±2.2 92.6±3.7 65.4±3.8 04 90.8±2.4 80.9±2.9 91.8±1.1 69.7±5.3 05 91.4±3.3 83.7±2.0 87.5±2.4 81.6±4.2

[0048] The experimental results show that aspartame, sucralose, stevioside and the like do not significantly improve the taste, but monellin significantly improves the taste.

[0049] Experimental Example 4: Screening of Packaging Mixtures

[0050] Instant donkey-hide gelatin granules are made from donkey-hide gelatin. Donkey-hide gelatin itself has a bad odor, which leads to the bad odor of instant donkey-hide gelatin granules. This problem is solved by coating the granules, and at the same time the solubility of the donkey-hide gelatin granules is improved.

[0051] Table 8 Screening comparison of inclusion compounds

[0052]

[0053]

[0054] Table 9 Properties of donkey-hide gelatin particles prepared in Experimental Example 4

[0055] Serial number granularity Color Solubility Taste 01 91.4±3.3 83.7±2.0 87.5±2.4 81.6±4.2 02 86.6±3.1 84.9±3.0 86.9±2.9 80.3±1.7 03 76.8±4.2 84.6±2.2 64.3±3.6 80.6±2.7 04 86.9±3.4 86.3±2.7 86.7±2.5 80.8±3.1 05 90.2±2.0 85.3±2.6 85.9±2.9 80.4±3.3

[0056] The above results show that the use of chitosan for coating will lead to a decrease in the solubility of the particles, while the use of hydroxypropyl methylcellulose and polyethylene glycol has little effect on the solubility of donkey-hide gelatin particles. The solubility and taste of the particles prepared by drying + coating and binder + coating alone are not as good as those prepared by the combined action of binder, drying and coating. The above two coating agents were investigated for their anti-hygroscopicity properties.

[0057] The four samples No. 01, 03 to 05 in Experimental Example 4 were placed in a desiccator containing a sulfuric acid solution with a relative humidity of 85% and maintained at 25° C. for 7 days. The samples were then weighed and the moisture absorption percentage was calculated.

[0058] Table 10 Hygroscopicity percentage of donkey-hide gelatin particles prepared in Experimental Example 4

[0059] Serial number 01 03 04 05 Moisture absorption percentage 42％ 10％ 14％ 5％

[0060] The above experimental results show that using 1.5% hydroxypropyl methylcellulose and 0.5% polyethylene glycol as coating agents can reduce the hygroscopicity of instant donkey-hide gelatin particles to the greatest extent.

[0061] Experimental Example 5 Investigation on the reduction of dryness of donkey-hide gelatin

[0062] Long-term consumption of donkey-hide gelatin may cause internal heat. Animal experiments were conducted on the samples in Experimental Example 2 to determine whether the experimental animals had internal heat and the degree of internal heat through changes in the activity of SDH in liver cells.

[0063] Sixty female Wistar rats, weighing 180-220 g and aged 2-3 months, were selected and randomly divided into 6 groups, namely, a normal control group and groups 1-5 of instant donkey-hide gelatin granules, with 10 rats in each group.

[0064] The animals in the normal control group drank normal water and were fed conventionally, and each mouse was gavaged with 4 ml of normal saline daily.

[0065] The instant donkey-hide gelatin granules group was given normal drinking water and conventional feeding, and each mouse was gavaged with 4g of instant donkey-hide gelatin granules daily. After 4 weeks of continuous feeding, the changes in the activity of SDH in liver cells of each group were detected (refer to Chen Qun et al., "Study on the Activity of Succinate Dehydrogenase in Liver Cells of Rats with Excessive Heat Syndrome and Deficiency Heat Syndrome Models").

[0066] Table 11 Results of research on different processing instant donkey-hide gelatin granules causing internal heat in animals

[0067] Group Technology Number of animals SDH (μmol / (min*mg) Normal control group -- 10 4.527±0.352 Instant donkey-hide gelatin granules group 1 No. 01 10 5.935±0.425 Instant donkey-hide gelatin granules group 2 No. 02 10 5.894±0.446 Instant donkey-hide gelatin granules group 3 No. 03 10 5.403±0.452 Instant donkey-hide gelatin granules group 4 No. 04 10 5.444±0.541 Instant donkey-hide gelatin granules group 5 No. 05 10 4.729±0.391

[0068] The experimental results showed that the SDH data of each group taking instant donkey-hide gelatin granules were higher than those of the normal control group, but the increase in process 05 was not obvious, while the increases in the other groups were more obvious, indicating that the use of microwave drying and infrared drying methods in the preparation of granules can reduce the probability of animals getting angry.

[0069] Experimental Example 6 Study on the stability of instant donkey-hide gelatin granules made by different processes

[0070] The stability of instant donkey-hide gelatin granules produced by different processes was investigated according to the standards for instant donkey-hide gelatin granules.

[0071] Process 1: Batch No. 20220801

[0072] 1. Preparation of gelatin powder: Grind the donkey-hide gelatin block into fine powder with a particle size of 80-120 mesh;

[0073] 2. Preparation of adhesive: Prepare adhesive by mixing donkey-hide gelatin powder and water in a ratio of 1:40;

[0074] 3. Boiling granulation: put the donkey-hide gelatin powder into the raw material container of the boiling granulator, add 2% of the weight of the donkey-hide gelatin adhesive for boiling granulation, the spray pressure is 0.25Mpa, the auxiliary spray pressure is 0.05Mpa, and the negative pressure is 2000pa. The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0075] 4. Drying: Place the qualified particles in an oven at 105°C and dry them to sterilize until the moisture content does not exceed 5%;

[0076] Process 2: Batch No. 20220802

[0077] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0078] 2. Preparation of adhesive: Prepare adhesive by mixing donkey-hide gelatin powder and water in a ratio of 1:40;

[0079] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2% of the weight of donkey-hide gelatin into the infusion tank, spray pressure is 0.25MPa, auxiliary spray pressure is 0.05Mpa, negative pressure is 2000pa. The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0080] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 600KW and dry for 10 minutes;

[0081] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 80°C for 1 hour;

[0082] 6. Coating: After granulation, place the granules in an automatic coating machine and spray 1.5% hydroxypropyl methylcellulose and 0.5% polyethylene glycol in 70% ethanol solution as a coating agent in a ratio of 1:1 for coating.

[0083] Process three: Batch number 20220803

[0084] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0085] 2. Preparation of adhesive: prepare adhesive by mixing donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water in a ratio of 1:2:3:40;

[0086] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2% of the weight of donkey-hide gelatin into the infusion tank, spray pressure is 0.25MPa, auxiliary spray pressure is 0.05Mpa, negative pressure is 2000pa. The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0087] 4. Drying: Place the qualified particles in an oven at 105°C and dry them to sterilize until the moisture content does not exceed 5%;

[0088] 5. Coating: After granulation, place the granules in an automatic coating machine and spray 1.5% hydroxypropyl methylcellulose and 0.5% polyethylene glycol in 70% ethanol solution as a coating agent in a ratio of 1:1 for coating.

[0089] Process 4: Batch No. 20220804

[0090] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0091] 2. Preparation of adhesive: prepare adhesive by mixing donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water in a ratio of 1:2:3:40;

[0092] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2% of the weight of donkey-hide gelatin into the infusion tank, spray pressure is 0.25MPa, auxiliary spray pressure is 0.05Mpa, negative pressure is 2000pa. The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0093] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 600KW and dry for 10 minutes;

[0094] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 80°C for 1 hour;

[0095] Process 5: Batch No. 20220805

[0096] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0097] 2. Preparation of adhesive: prepare adhesive by mixing donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water in a ratio of 1:2:3:40;

[0098] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2% of the weight of donkey-hide gelatin into the infusion tank, spray pressure is 0.25MPa, auxiliary spray pressure is 0.05Mpa, negative pressure is 2000pa. The standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0099] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 600KW and dry for 10 minutes;

[0100] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 80°C for 1 hour;

[0101] 6. Coating: After granulation, place the granules in an automatic coating machine and spray 1.5% hydroxypropyl methylcellulose and 0.5% polyethylene glycol in 70% ethanol solution as a coating agent in a ratio of 1:1 for coating.

[0102] Table 12 Process 1 instant granule stability test results

[0103]

[0104] Table 13 Process 2 instant granule stability test results

[0105]

[0106]

[0107] Table 14 Results of stability study on process three instant granules

[0108]

[0109] Table 15 Results of stability study on process 4 instant granules

[0110]

[0111]

[0112] Table 16 Results of stability study on process 5 instant granules

[0113]

[0114]

[0115] In order to enable those skilled in the art to more clearly understand the technical solution of the present invention, the present invention is further described below in conjunction with specific embodiments. The embodiments of the present invention are only used to illustrate the technical solution of the present invention but are not used to limit the scope of the present invention.

[0116] Example 1: Batch No. 20220901

[0117] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0118] 2. Preparation of adhesive: Mix donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water according to 1:

[0119] The adhesive was prepared in a ratio of 1.8:3.3:40;

[0120] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2.5% of the weight of the glue into the infusion tank, spray pressure 0.3MPa, auxiliary spray pressure 0.1Mpa, negative pressure 4000pa, the standard of granulation is that the sum of the particles and powder that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0121] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 700KW and dry for 15 minutes;

[0122] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 70°C for 2 hours;

[0123] 6. Coating: After granulation, place the granules in an automatic coating machine with a mass ratio of donkey-hide gelatin granules to coating solution of 1:1.2. Spray in 70% ethanol solution of 1.5% hydroxypropyl methylcellulose and 0.4% polyethylene glycol as the coating solution for coating.

[0124] Example 2: Batch No. 20220902

[0125] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0126] 2. Preparation of adhesive: Mix donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water according to 1:

[0127] The adhesive was prepared in a ratio of 2.2:2.7:42;

[0128] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 2% of the weight of donkey-hide gelatin into the infusion tank, spray pressure 0.25MPa, auxiliary spray pressure 0.2Mpa, negative pressure 6000pa, the standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0129] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 800KW and dry for 10 minutes;

[0130] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 60°C for 2 hours;

[0131] 6. Coating: After granulation, place the granules in an automatic coating machine with a mass ratio of donkey-hide gelatin granules to coating solution of 1:0.8. Spray 1.6% hydroxypropyl methylcellulose and 0.5% polyethylene glycol in 70% ethanol as the coating solution for coating.

[0132] Example 3: Batch No. 20220903

[0133] 1. Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh;

[0134] 2. Preparation of adhesive: prepare adhesive by mixing donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water in a ratio of 1:2:3:38;

[0135] 3. Boiling granulation: put the glue powder into the raw material container of the boiling granulator, pour 3% of the weight of donkey-hide gelatin into the infusion tank, spray pressure 0.25MPa, auxiliary spray pressure 0.05Mpa, negative pressure 2000pa, the standard for making granules is that the sum of particles and powders that cannot pass through the No. 1 sieve and can pass through the No. 4 sieve shall not exceed 8%;

[0136] 4. Microwave drying: Place the above particles in a microwave drying oven at a power of 800KW and dry for 10 minutes;

[0137] 5. Infrared drying: Place the above particles in an infrared electric drying oven at 80°C for 1 hour;

[0138] 6. Coating: After granulation, place the granules in an automatic coating machine with a mass ratio of 1:1 between donkey-hide gelatin granules and coating solution. Spray in 70% ethanol solution of 1.5% hydroxypropyl methylcellulose and 0.6% polyethylene glycol as coating solution for coating.

[0139] Table 17 Results of stability study on process 5 instant granules

[0140]

[0141]

[0142] Table 18 Results of stability study on process 5 instant granules

[0143]

[0144] Table 19 Results of stability study on process 5 instant granules

[0145]

[0146]

Claims

1. A preparation process of instant donkey-hide gelatin granules, characterized in that: The steps include: (1) Preparation of rubber powder: crush the rubber block into fine powder with a particle size of 80-120 mesh; (2) Preparation of adhesive: preparing an adhesive by mixing donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water; (3) Boiling granulation: Put the rubber powder into the raw material container of the boiling granulator for granulation; (4) Microwave drying: drying the above particles in a microwave drying oven; (5) Infrared drying: drying the above particles in an infrared electric drying oven; (6) Coating: After granulation, coating is performed to obtain instant donkey-hide gelatin granules.

2. The preparation process of the instant donkey-hide gelatin granules according to claim 1, characterized in that: The adhesive is prepared by using donkey-hide gelatin powder, hydroxypropyl methylcellulose, sucrose ester-13 and water in a ratio of 1:1.8-2.2:2.7-3.3:38-42.

3. The preparation process of the instant donkey-hide gelatin granules according to claim 1, characterized in that: During boiling granulation in step (3), the gelatin powder and 2-3% of the weight of the adhesive of donkey-hide gelatin are poured into the infusion tank, the spray pressure is 0.25-0.35MPa, the auxiliary spray pressure is 0.05-0.2Mpa, and the negative pressure is 2000-6000pa.

4. The preparation process of the instant donkey-hide gelatin granules according to claim 1, characterized in that: The power of microwave drying is 600-800KW, and the drying time is 10-20 minutes.

5. The preparation process of the instant donkey-hide gelatin granules according to claim 1, characterized in that: The infrared drying temperature is 60℃-80℃, and the drying time is 1-2 hours.

6. The process for preparing instant donkey-hide gelatin granules according to claim 1, characterized in that: The donkey-hide gelatin granules also include flavoring agents.

7. The process for preparing instant donkey-hide gelatin granules according to claim 6, characterized in that: The flavoring agent is monellin.

8. The process for preparing instant donkey-hide gelatin granules according to claim 1, characterized in that: In step (6), the mass ratio of the coating solution to the donkey-hide gelatin particles during coating is 1:0.8-1.2, the coating solution is a 70% ethanol solution of 1.5%-1.6% hydroxypropyl methylcellulose and 0.5%-0.6% polyethylene glycol, and the coating process is: spraying the coating solution for coating.

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