Preparation method, equipment and system of columnar material

Abstract

The invention relates to the field of advanced manufacturing, in particular to a method, equipment and system for preparing a columnar material, digital light beams are projected to the surface of a moving foundation pillar, so that a photosensitive material is rapidly formed on the surface of the foundation pillar, and the novel columnar material is constructed. And performing image segmentation on each layer of slices by combining parameters such as the rotation speed of the foundation pillar, inputting the images into an optical machine according to a time sequence to form dynamic digital light beams, and projecting the dynamic digital light beams onto a photosensitive material on the surface of the foundation pillar so that the dynamic digital light beams are quickly stereoscopically formed on the surface of the foundation pillar. And the optimal historical printing conditions of different materials can be input into the fitting model to obtain the fitting coefficient, so that the optimal and stable printing condition data is obtained. The printing condition data comprises exposure time, light intensity, projection area, base column moving speed and the like; wherein the base column movement comprises rotation and translation. According to the invention, the construction of a multi-material complex curved surface structure, such as intelligent integral forming of a single-layer or multi-layer complex columnar structure, can be realized in a matched manner.

Description

Technical Field

[0001] The present invention relates to the field of advanced manufacturing, and in particular to a method, equipment and system for preparing columnar materials. Background Art

[0002] 3D printing, also known as additive manufacturing, is a technology that can directly manufacture three-dimensional physical objects based on digital models. It can be customized according to individual needs to meet the needs of personalization and small-batch production. It can manufacture complex internal structures, such as lattice structures, hollow structures, etc., which are difficult or impossible to achieve in traditional manufacturing. Some 3D printing technologies can simultaneously use composite materials with multiple hardness, colors or functions and different cells for uniform or gradient printing, and carry out targeted time and space treatment for each disease, slowly or quickly releasing drugs at different times.

[0003] With the development of 3D printing technology, columnar materials, as a type of material with special structure and properties, have become a hot spot for research and application. These technologies can precisely control the microstructure of materials, thereby optimizing their macroscopic properties. Columnar materials refer to hollow or solid columnar structures, which show wide application potential in many fields, including but not limited to aerospace, medical devices, building structure reinforcement, thermal management of electronic devices, etc. For example, in the biomedical field, columnar bone scaffolds can promote cell growth and tissue regeneration; in the aerospace field, lightweight and high-strength columnar structural materials can be used to manufacture aircraft and satellite parts.

[0004] The formation of new three-dimensional structures on the surface of columnar materials through additive manufacturing technology can support the research and development of a variety of innovative products and has a significant market demand. At present, there have been reports of using extrusion 3D printing technology to perform three-dimensional printing on the surface of columnar materials, but the slow speed of extrusion 3D printing seriously limits the application of this technology. The printing technology based on digital light processing 3D has characteristics such as fast speed, but this technology is usually used to print three-dimensional structures on planes, and it is difficult to print complex 3D structures on curved surfaces such as the surface of columnar materials.

[0005] For example, patent application CN113679506A discloses a simple method for preparing a 3D printed inner wall micro-patterned nerve conduit. This method uses a writing-like 3D method to print "ink" on a tungsten steel rod with a micro-pattern structure to prepare a nerve conduit that can induce directional cell migration. However, the extrusion printing speed used in this method is slow and is only suitable for preparing nerve conduits with a single structure and morphology.

[0006] In addition, patent application CN110757799A also discloses a device and manufacturing process suitable for preparing a nerve conduit, which is used to prepare a nerve conduit by coating the ink on the sleeve through the extruder head in the X-axis direction at high speed with the low-speed rotation of the forming shaft. However, the structure and operation of the printing instrument are too complicated, and the fixed rod, fixed seat, hand wheel, etc. need to be manually adjusted for positioning and printing, which is inconvenient to operate.

[0007] For another example, CN116252477A also provides a multi-degree-of-freedom biological 3D printing system for in vitro reconstruction of curved tissues. A six-degree-of-freedom motion device and a variety of extrusion kits, the six-degree-of-freedom motion device includes an X-axis mobile platform and a Z-axis mobile platform fixed to a mounting table, a Y-axis mobile platform slidably mounted on the X-axis mobile platform, an XY rotation axis slidably mounted on the Y-axis mobile platform, a YZ rotation axis rotatably mounted on the XY rotation axis, an XZ rotation axis rotatably mounted on the YZ rotation axis, a cantilever slidably mounted on the Z-axis mobile platform, an extrusion kit mounted on the cantilever, and the extrusion kit can move to the top of the XZ rotation axis to print on the curved surface of the XZ rotation axis.

[0008] However, these traditional photocuring solutions generally have problems such as cumbersome operation, low printing efficiency, and unstable multi-layer printing.

[0009] Therefore, there is an urgent need for a method that can improve the printing efficiency and printing quality for complex columnar materials. Summary of the invention

[0010] The purpose of the present invention is to provide a method, device and system for preparing columnar materials, which partially solve or alleviate the above-mentioned deficiencies in the prior art and can improve printing efficiency and printing quality. In the present invention, by utilizing the innovation and collaboration of technologies such as digital light processing, 3D image processing, automatic control, and photocurable materials, a method, device and system for rapid 3D printing of three-dimensional structures on the surface of columnar materials are developed, which has a good application prospect.

[0011] In view of the problems involved in the background technology, the present application has developed a customized multifunctional columnar material preparation device, which includes: a base column, the outer surface of which can absorb a certain thickness of photocurable liquid; a sample loading element is arranged on the lower side of the base column, and the sample loading element is provided with a sample loading pool, which can accommodate the photocurable liquid, and at least a part of the base column is immersed in the sample loading pool, and the rotation speed of the base column is adjusted to match the curing time of different photocurable liquids. The optical machine projects light (or photos) with a specific pattern onto the base column, and the photocurable liquid will be cured on the base column according to the specific shape of the design, thereby realizing the preparation of columnar materials with multi-layer complex structures that are customizable, efficient, and highly uniform. In other words, the present application proposes a fast rotation 3D printing technology. For example, the fast rotation 3D printing technology proposed in the present application can prepare one to multiple layers of nerve conduits with different components, structures, and morphologies according to actual needs. Different photocurable liquids with photoinitiators are printed in any customizable blue light pattern on the outer surface of a base column with a diameter of 1-3 mm that has been treated differently. These treatments include but are not limited to casting and freeze-drying. Through these treatments, the inner layer of the catheter can have different structures and morphologies customized on demand, promote the growth and migration of nerve cells, improve the mechanical properties of the catheter, and solve the problem that a single hydrogel cannot be sutured.

[0012] The printing technology of the present invention can customize the required pattern through computer software, and the digital light beam can be accurately focused on the printing area, with higher printing accuracy; the entire printing process is controlled by a computer, which can change the light intensity and rotation speed, and print at a fixed time, and the operation is fast and easy.

[0013] In order to solve the technical problems mentioned above, the present invention specifically adopts the following technical solutions: The first aspect of the present invention is to provide a method for preparing a columnar material, the method comprising: S001, obtaining a three-dimensional digital model of the columnar material; S002, performing layered slicing processing on the three-dimensional digital model along the thickness direction to obtain corresponding multi-layer slices; S003, obtaining a first slice image compatible with a preparation device for the columnar material according to the slices; wherein the preparation device comprises: a base column, and the base column is configured to be able to rotate around its axial direction, the base column has a diameter and a working length, and the outer surface of the base column can absorb a certain thickness of a light-cured liquid layer; an optical machine, used to project a digital light beam onto the outer surface of the base column, and the area where the digital light beam effectively covers the base column is projection working area; correspondingly, the first slice image is a pattern corresponding to the slice after spreading, and the height of the first slice image matches the circumference of the base column, and the width of the first slice image matches the working length; S004, a set segmentation method is adopted to segment and acquire a plurality of second slice images along the width direction of the first slice image, and the set segmentation method requires that the height of the second slice image matches the height of the projection working area, and the second slice image is associated with a corresponding projection order; S005, the base column rotates at a set rotation speed, so that the second slice images are projected onto the outer surface of the base column in sequence according to the projection order, so that the photocurable liquid is sequentially formed according to the pattern on the second slice image under the projection of the corresponding digital light beam.

[0014] In some embodiments, the number of pixel rows of the first slice image satisfies a set slicing rule, and the slicing rule includes: ; ; ; ; ; in, n max is the maximum number of pixel rows in the height direction of the first slice image, N H 、Nw are the maximum number of pixels of the projection working area of ​​the digital light beam in the height direction and the width direction respectively; H p 、W p point are respectively the height and width of the projection working area of ​​the digital light beam; l is the working length, h p is the circumference of the base column, dis the diameter. In some embodiments, the thickness of a layer of the slice is , correspondingly, the pixel height of the first slice image of the first layer projected on the base column is ;No. The maximum pixel height of the first slice image of the layer .

[0015] In some embodiments, the first slice image is a grayscale image or a binary image, and correspondingly, S004 includes: extracting the lines composed of each row of pixels of the first slice image as subsets in sequence, wherein the black pixels are identified as the background of the second slice image, and the non-black pixels are identified as the pattern of the second slice image; and creating multiple second slice images according to the black pixels and the non-black pixels.

[0016] In some embodiments, the total number of the second slice images formed corresponding to the multiple slices is: ; m is the number of slices, is the thickness of one slice, n total is the total number of the second slice images of the three-dimensional digital model, n i For the i The total number of the second slice images of the slice layer.

[0017] In some embodiments, the steps further include: S006, monitoring the light curing efficiency of the light curing liquid; S007, when the light curing efficiency is less than the set light curing efficiency, correcting the second slice image and the projection delay, wherein the projection delay refers to the time a single second slice image stays on the base column; the step of correcting the second slice image and the projection delay includes: merging at least two second slice images of the slice of the layer to be corrected to obtain a corrected slice image; wherein the layer to be corrected is the first i layer, and the corresponding height of the corrected slice image is ; Determine the projection delay according to the corrected slice image, the projection delay is: , n i For the i the total number of the corrected slice images of the slices of the layer to be corrected, is the rotation speed.

[0018] In some embodiments, S005 further includes the step of: selecting printing conditions of the three-dimensional digital model according to the fitting model; wherein the printing conditions include: the thickness of the slice, the printing time of one layer of the slice, the light intensity, and the diameter of the base column; the fitting model includes: ;in, is the thickness, is the fitting coefficient, is the printing time, is the light intensity, is the diameter.

[0019] The present invention correspondingly provides a preparation system for columnar materials, the system comprising: a model acquisition module, used to acquire a three-dimensional digital model of the columnar material; a slicing module, used to perform layered slicing processing on the three-dimensional digital model along the thickness direction, correspondingly obtaining multi-layer slices; a first image acquisition module, used to acquire a first slice image adapted to a preparation device for the columnar material according to the slices; wherein the preparation device comprises: a base column, and the base column is configured to be rotatable around its axial direction, the base column has a diameter and a working length, and the outer surface of the base column can absorb a certain thickness of light-curable liquid; an optical machine, used to project a digital light beam onto the surface of the base column, and the area where the digital light beam effectively covers the base column is the projection working area; correspondingly, the first The slice image is a pattern corresponding to the slice after it is spread, and the height of the first slice image matches the circumference of the base column, and the width of the first slice image matches the working length; the second image acquisition module is used to adopt a set segmentation method to segment and acquire multiple second slice images along the width direction of the first slice image, and the set segmentation method requires that the height of the second slice image matches the projection working area, and the second slice image is associated with a corresponding projection order; the printing module is used to control the base column to rotate at a set rotation speed, so that the second slice images are projected onto the outer surface of the base column in sequence according to the projection order, so that the photocurable liquid is formed in sequence according to the pattern on the second slice image under the projection of the corresponding digital light beam.

[0020] The present invention also provides a preparation device for columnar materials, comprising: a base column, the base column having a diameter and a length, and the base column having a curved outer surface; a sample loading element, the sample loading element being capable of containing a photocurable liquid; wherein the sample loading element has a sample loading pool for containing the photocurable liquid, and the base column is configured so that the outer surface can be at least partially immersed in the photocurable liquid; or, the sample loading element has at least one nozzle, and the nozzle can spray the photocurable liquid on the outer surface; a supporting element, the supporting element being used to support the base column and capable of driving the base column to move in a curved manner. The base column is rotated around its axis at a set speed, and the base column can adsorb and form a photocurable liquid layer with a certain thickness on the outer surface during the rotation; an optical machine is used to project a digital light beam onto the surface of the base column; a first spacing is provided between the projection end of the optical machine and the surface of the base column at the initial moment of printing; a moving element is used to drive the base column to move along the projection direction; wherein, when the base column grows a structural layer with a first thickness, the moving element can drive the base column to move so that the spacing between the projection end and the outer surface is maintained at or approximately the first spacing.

[0021] In some embodiments, it further includes: a heating device, which is used to heat the base column and / or the sample loading pool; and / or the preparation equipment also includes: a photographic device, which is used to collect image information of the base column.

[0022] Beneficial technical effects: In stark contrast to the prior art of segmented printing, the applicant has proposed a technical solution that can perform synchronous printing on a columnar surface. The present invention relatively fixes the photocurable liquid (also known as printing ink) and only rotates the base column to grow a layer of columnar material on the base column. This synchronous printing is not only conducive to improving the strength and uniformity of the formed columnar material, but also can effectively improve the printing efficiency.

[0023] Specifically, based on the comprehensive division of typical parameters with finite properties such as thickness, height, and timing, the present invention proposes a method of converting complex columnar materials (especially columnar objects involving multi-layer structures) into multiple projection images (i.e., slice images) that conform to the base column morphology and projection rules, so that a layer structure can be generated synchronously and continuously thereon with the help of the base column rotation process (specifically, the columnar material can be synchronously generated in the axial direction of the base column and grow continuously in the radial direction).

[0024] Furthermore, the applicant noted that printing parameters (such as printing time, light intensity, etc.) will also have a significant impact on the growth of columnar materials and the final forming quality, and the printing parameters need to be adaptively adjusted for different types of customized columnar materials. Therefore, when facing large-scale columnar material production, or whenever a new customized columnar material needs to be prepared, the problem of parameter selection will be faced, and this parameter selection process will also extend the preparation cycle of the columnar material. In order to reduce the workload in the parameter selection process, the present invention proposes a method for quickly screening out recommended fitting parameters. Specifically, the present invention constructs a printing prediction model by comprehensively selecting equipment parameters such as light intensity and time, and product parameters such as diameter, wherein the product parameters can be independently set by the user in combination with customized standards, and then the relative relationship between printing light intensity and time can be predicted and derived by combining the set product parameters with the fitting coefficient, thereby assisting the user to quickly set the light intensity or time that meets the conditions.

[0025] Furthermore, the present invention selects product parameters - thickness, printing liquid characteristics (such as adsorption performance or initiator concentration) as key matching factors, so as to comprehensively select historical printing data that meets the current printing conditions through product parameters and liquid characteristics, and directly combines historical printing data to predict the corresponding fitting coefficient through the printing prediction model, and the final user can first set the printing parameters through the predicted fitting coefficient. The prediction of the fitting coefficient can reduce the testing workload required by the user before formal printing.

[0026] Among them, by reasonably setting the printing light intensity and printing time (the printing time further limits the rotation speed of the base column), it is ensured that the liquid can be evenly coated on the surface of the base column at an appropriate printing time, and the liquid will not be detached due to excessive rotation speed. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, each element or part is not necessarily drawn according to the actual scale. Obviously, the drawings described below are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without paying creative labor.

[0028] Figure 1 is a perspective schematic diagram of a printing device in an exemplary embodiment of the present invention; Figure 2 is a schematic structural diagram of a printing device in an exemplary embodiment of the present invention; Figure 3 is a top view of a printing device in an exemplary embodiment of the present invention; Figure 4 A schematic diagram of the structure of a groove of a printing device in an exemplary embodiment of the present invention; Figure 5 is a schematic structural diagram of a printing device in an exemplary embodiment of the present invention; Figure 6 is a schematic structural diagram of a printing device in another exemplary embodiment of the present invention; Figure 7 It is a schematic structural diagram of an intermediate mechanism of a columnar material preparation device in another exemplary embodiment of the present invention; Figure 8 It is a structural schematic diagram of a columnar material preparation device in another exemplary embodiment of the present invention; Fig. 9 It is a partial structural schematic diagram of a columnar material preparation device in another exemplary embodiment of the present invention; Fig.10 is a schematic flow chart of steps of a printing method in an exemplary embodiment of the present invention; Fig.11a It is a schematic diagram of a process of slicing and cutting a three-dimensional digital model in an exemplary embodiment of the present invention; Fig.11b It is a structural schematic diagram of a three-dimensional digital model in another exemplary embodiment of an exemplary embodiment of the present invention; Fig.11c for Fig.11b A schematic diagram of the process of cutting and combining the second slice image of the slice layer is shown; Fig.12 Schematic diagram of method flow in other embodiments of the present invention; Fig.13 It is a schematic diagram of a photo of a real object prepared based on the printing method shown in the present invention.

[0029] Figure numerals: first base 1, first driving mechanism 2, first bracket 3, second bracket 4, second base 5, first clamping head 6, first supporting portion 7, groove 71, supporting end 7a, liquid supply end 7b, reinforcement 73, bridge bracket 8, second clamping head 9; moving mechanism 10, connecting plate 101, second driving mechanism 102, control module 11, heating mechanism 12, heating element 121, temperature controller 122, projection mechanism 13; three-dimensional digital model 01, spreading model 02, first slice image A021, first slice image B022, second slice image 03. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0031] Herein, the suffixes such as "module", "component" or "unit" used to represent elements are used only to facilitate the description of the present invention and have no specific meaning in themselves. Therefore, "module", "component" or "unit" can be used in a mixed manner. Herein, the orientation or position relationship indicated by the terms "upper", "lower", "inner", "outer", "front", "back", "one end", "the other end" and the like are based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are used only for descriptive purposes and cannot be understood as indicating or implying relative importance. Herein, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected" and the like should be understood in a broad sense, for example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, an indirect connection through an intermediate medium, or a communication between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific circumstances.

[0032] "And / or" herein includes any and all combinations of one or more listed related items. "Multiple" herein means two or more, i.e., it includes two, three, four, five, etc. As used in this specification, the term "approximately" is typically expressed as + / -5% of the value, more typically + / -4% of the value, more typically + / -3% of the value, more typically + / -2% of the value, even more typically + / -1% of the value, even more typically + / -0.5% of the value. In this specification, some embodiments may be disclosed in a format that is in a certain range. It should be understood that this description of "being in a certain range" is only for convenience and brevity, and should not be interpreted as a rigid limitation to the disclosed range. Therefore, the description of the range should be considered to have specifically disclosed all possible sub-ranges and independent numerical values ​​within this range. For example, the description of the range 1-6 should be considered to have specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within this range, such as 1, 2, 3, 4, 5, and 6. The above rules apply regardless of the breadth of the range.

[0033] The prior art adopts a segment-by-segment printing technology route, that is, the extruder (used to extrude printing ink) moves along the axial direction of the forming shaft so that the printing ink is formed one segment after another in the axial direction of the forming shaft (in other words, the solution adopted by the prior art is segmented printing in the length direction). However, the applicant found that the nerve conduit prepared based on the segment-by-segment printing technology route has poor strength and uniformity, and because the extruder needs to continuously move from one end of the forming shaft to the other end to complete the printing of a layer of nerve conduit, the printing time is long and the efficiency is low.

[0034] Different from the existing technology route of printing segment by segment in the length direction, see Figure 1-Figure 10 The present invention proposes a technical solution capable of synchronous printing. Specifically, the present invention grows a layer of columnar material on the base column by relatively fixing the photocurable liquid (also known as printing ink) and rotating only the base column. This synchronous printing is not only conducive to improving the strength and uniformity of the formed columnar material, but also can effectively improve the printing efficiency.

[0035] like Fig.11b As shown in the figure, the "width (W)" of the image refers to the length along the axial direction of the base column. The "height (H)" of the image refers to the direction perpendicular to the width. In order to explain the continuous preparation method of the columnar material of the present invention, the following is a Fig.11a Take the slicing process as an example to describe it: Fig.11aA columnar three-dimensional digital model 01 is provided, and the three-dimensional digital model 01 is spread to obtain a spread model 02, and the spread model 02 is cut into multiple slices along its thickness direction to obtain a set of slice results. Correspondingly, a first slice image A021 and a first slice image B022 are generated according to the slice results (such as a slice A with a rectangular pattern or a slice B with a triangular pattern). The first slice image completely depicts the pattern information in the corresponding slice.

[0036] Furthermore, for the first slice image, the image is further divided along its width direction (eg Fig.11a As shown in the figure, the plurality of second slice images 03 are sequentially cut into a plurality of second slice images 03, and the plurality of second slice images 03 are associated with a corresponding projection order (specifically, it can be a sequential projection order, such as the first image, the second image, etc.; or the projection order can also be set to a set projection time); thus, when the base column rotates one circle, the optical machine just projects the plurality of second slice images 03 under one slice onto the base column in sequence, and causes the pattern in the slice to grow on the base column accordingly.

[0037] In summary, based on the comprehensive classification of thickness, height and timing, the present invention provides a printing technology capable of continuously printing columnar materials. Figure 10-12 As shown, the present invention provides a method for preparing a columnar material, the method comprising: S001, obtaining a three-dimensional digital model of the columnar material; S002, performing layered slicing processing on the three-dimensional digital model along the thickness direction to obtain corresponding multi-layer slices; S003, acquiring a first slice image adapted to the preparation device of the columnar material according to the slice; wherein the preparation device comprises: a base column, and the base column is configured to be rotatable around its axial direction, the base column has a diameter and a working length, and the outer surface of the base column can absorb a photocurable liquid layer of a certain thickness; an optical machine, used to project a digital light beam onto the outer surface of the base column, and the area of ​​the base column effectively covered by the digital light beam is the projection working area; correspondingly, the first slice image is a pattern corresponding to the slice after spreading, and the height of the first slice image matches the circumference of the base column, and the width of the first slice image matches the working length; S004, using a set segmentation method to segment and acquire a plurality of second slice images along the width direction of the first slice image, wherein the set segmentation method requires that the height of the second slice image matches the height of the projection work area, and the second slice images are associated with a corresponding projection order; S005, the base column rotates at a set rotation speed, so that the second slice image is sequentially projected onto the outer surface of the base column according to the projection order, so that the light-curable liquid is sequentially formed according to the pattern on the second slice image under the projection of the corresponding digital light beam. That is, the corresponding 3D columnar material is prepared on the base column by digital light beam projection.

[0038] In some embodiments, the number of pixel rows of the first slice image satisfies a set slicing rule, and the slicing rule includes: ; ; ; ; ; in, n max is the maximum number of pixel rows in the height direction of the first slice image, N H 、Nw are the maximum number of pixels of the projection working area of ​​the digital light beam in the height direction and the width direction respectively; H p 、W p point are respectively the height and width of the projection working area of ​​the digital light beam; l is the working length, h p is the circumference of the base column, d is the diameter.

[0039] In this embodiment, it is preferred to ensure that the first slice image just covers and fits the outer surface of the base column, so that after the first slice image is projected, a structure corresponding to the corresponding slice layer can be generated on the base column.

[0040] In some embodiments, the thickness of a layer of the slice is , correspondingly, the pixel height of the first slice image of the first layer projected on the base column is ;No. The maximum pixel height of the first slice image of the layer is .

[0041] In this embodiment, it is preferred to ensure that the thickness of each layer of slices is relatively uniform, so as to ensure that the dosage of the photocurable liquid of each layer of slices is close, so that the finally formed 3D columnar material has better uniformity.

[0042] In some embodiments, the first slice image is a grayscale image or a binary image, and correspondingly, S004 includes: extracting the lines composed of each row of pixels of the first slice image as subsets in sequence, wherein the black pixels are identified as the background of the second slice image, and the non-black pixels are identified as the pattern of the second slice image; and creating multiple second slice images according to the black pixels and the non-black pixels.

[0043] In some embodiments, the total number of the second slice images formed corresponding to the multiple slices is: ; m is the number of slices, is the thickness of one slice, n total is the total number of the second slice images of the three-dimensional digital model, n i For the i The total number of the second slice images of the slice layer.

[0044] Specifically, along the rotation direction of the column base, the lines composed of each row of pixels in the first slice image (grayscale image or binary image) of each layer are extracted as subsets in sequence (black pixels correspond to the background of the projection image, and non-black pixels are actually exposed pixels, such as Fig.11a As shown in the figure, the line pattern sequence is obtained by processing each slice layer. (That is, the total number of second slice images generated by one slice).

[0045] In some embodiments, the method further includes the following steps: S006, monitoring the light curing efficiency of the light curing liquid; S007, when the light curing efficiency is less than the set light curing efficiency, correcting the second slice image and the projection delay, wherein the projection delay refers to the time a single second slice image stays on the base column; the step of correcting the second slice image and the projection delay includes: At least two of the second slice images of the slice of the layer to be corrected are merged to obtain a corrected slice image; wherein the layer to be corrected is the first i layer, and the corresponding height of the corrected slice image is ; The projection delay is determined according to the modified slice image, and the projection delay is: , n i For the ithe total number of the corrected slice images of the slices of the layer to be corrected, is the rotation speed.

[0046] This embodiment also proposes a correction mechanism for correcting the cutting result. By comprehensively correcting the height and projection delay of the second slice image, the strength and uniformity of the columnar material can be further improved.

[0047] For example, in some embodiments, see Fig.11c As shown, two adjacent line patterns (equivalent to the second slice image with a height H of only 1 pixel) can be appropriately merged into pixel widths of 2, 3, ..., ( ), that is, it is assumed that each layer is merged with the same line width (that is, the height of the second slice image), but the line merging widths of different layers are allowed to be different. Correspondingly, the number of patterns formed by the layer after correction is: .

[0048] Also, see Fig.13 As shown in the figure, after printing tests, the printing scheme proposed by the present invention can still maintain good printing quality when preparing complex columnar materials. Fig.13 It can be seen that the columnar material has a smooth surface and a clear morphology. Specifically, Fig.13 The main components of the photocurable raw materials used are: 15% PEGDA and 0.1% LAP photoinitiator.

[0049] In some embodiments, S005 further includes the step of: selecting printing conditions of the three-dimensional digital model according to the fitting model; wherein the printing conditions include: the thickness of the slice, the printing time of one layer of the slice, the light intensity, and the diameter of the base column; the fitting model includes: ;in, is the thickness, is the fitting coefficient, is the printing time, is the light intensity, is the diameter.

[0050] In order to more clearly illustrate the technical solution adopted by the present invention, Figure 1-Figure 9 As shown, several exemplary preparation devices provided by the present invention are explained: Specifically, the present invention provides a preparation device for columnar materials (or a rotary printing device), comprising: A base column, wherein the base column has a diameter and a length, and the base column has a curved outer surface; A sample adding element, wherein the sample adding element can contain a photocurable liquid; wherein the sample adding element has a sample adding pool for containing the photocurable liquid, and the base column is configured so that the outer surface can be at least partially immersed in the photocurable liquid; preferably, baffles can be provided at both ends of the sample adding pool, so that an accommodating cavity is formed between the inner wall of the sample adding pool and the baffles, so that a certain amount of photocurable liquid can be contained in the cavity; or, the sample adding element has at least one nozzle, and the nozzle can spray the photocurable liquid on the outer surface, so that a layer of photocurable liquid can be uniformly adsorbed on the base column; A supporting element, the supporting element is used to support the base column, and can drive the base column to rotate around its axial direction at a set speed, and the base column can adsorb and form a photocurable liquid layer with a certain thickness on the outer surface during the rotation process; An optical machine, used for projecting a digital light beam onto the surface of the base column; a first distance exists between the projection end of the optical machine and the surface of the base column at the initial printing moment; A moving element, wherein the moving element is used to drive the base column to move along the projection direction; wherein, when the base column grows a structural layer having a first thickness, the moving element can drive the base column to move so that the distance between the projection end and the outer surface is maintained at or approximately the first distance.

[0051] For example, the moving element can move up and down in the vertical direction to adjust the size of the area of ​​the base column immersed in the photocurable liquid.

[0052] See also Figure 1As shown, a specific configuration scheme of the preparation equipment is as follows: the supporting element may include: a first base 1, on which a first driving mechanism 2 is arranged; a first bracket 3 arranged on the first base 1; a first clamping head 6, the first clamping head 6 is arranged on the first bracket 3 to be fixed through the first bracket 3, and the first end of the first clamping head 6 is connected to the output end of the first driving mechanism 2, and the second end of the first clamping head 6 is used to fix the first end of the base column; the base column has a columnar outer surface, and the columnar outer surface is used to provide a molding platform for the photocurable liquid (or raw material, printing ink, biological ink, etc.) to guide the photocurable liquid to grow a columnar material (preferably a nerve conduit) on the base column; the supporting element may also include: a second bracket 4, a second clamping head 9, the second clamping head 9 is arranged on the second bracket 4, and the The second clamping head 9 is used to fix the second end of the base column; the loading element may include: a second base 5, a first supporting portion 7 is provided on the second base 5, and a groove 71 (equivalent to the loading pool) adapted to the shape of the base column is provided at the upper end of the first supporting portion 7, the groove is used to accommodate liquid, and the first supporting portion is preferably made of flexible material; the moving element may include: a moving mechanism 10, the moving mechanism 10 is used to drive the base column to reciprocate along the height direction; the moving mechanism includes: a connecting plate 101, the connecting plate 101 is connected to the second base 5; a second driving mechanism 102, the second driving mechanism 102 is connected to the second base to drive the second base 5 to move along the height direction; the preparation equipment may further include: a heating device, such as a heating mechanism 12, the heating mechanism is used to heat the liquid.

[0053] In some embodiments, the first and second clamping heads can be disposed on the same base. In some embodiments, the cross-sectional structure of the groove is semicircular. Figure 7 As shown, the heating mechanism comprises: a heating element 121 having a certain length, the heating element 121 being arranged at the lower end of the first supporting portion 7; a temperature controller 122 (see Fig. 9 As shown in FIG. 1 ), the temperature controller 122 is used to control the heating temperature of the heating element. In addition, the setting of the heating element with a certain length can meet the uniform heating requirement of the liquid on the one hand, and can support the flexible material on the other hand. This dual function can further control the overall weight of the intermediate mechanism to reduce the moving load of the moving mechanism.

[0054] The process of using the printing device in this embodiment to complete multi-layer printing is as follows: The first support portion is positioned at a first height, at which time the base column can be partially immersed in the liquid in the groove; the base column is controlled to rotate one circle so that a layer of nerve conduits grows on the base column; the first support portion is raised to a second height, so that the base column can continue to be partially immersed in the liquid in the groove; the base column is controlled to rotate one circle again so that a second layer of nerve conduits grows on the base column; this cycle is repeated multiple times, so that multiple layers of nerve conduits can be quickly grown on the base column.

[0055] For example, the moving distance in the height direction (and the distance has both positive and negative directions) is input into the control module 11 (such as a computer connected to the second driving mechanism), where the positive value represents the rising distance (mm) of the base column and the negative value represents the descending distance (mm) of the base column. The second driving mechanism will drive the movement of the intermediate mechanism to change the height of the groove, thereby realizing customizable coating of single or multiple layers of different materials on the base column.

[0056] That is to say, in this embodiment, the height of the base column is relatively fixed, and customized multi-layer printing of columnar materials can be completed by moving only the lightweight first support part. Among them, the surface of the first support part made of flexible material also has flexible characteristics, so that when the base column accidentally touches its surface, its surface will not cause damage to the material grown on the base column, and the lighter flexible material can also reduce the load of the moving mechanism 10. In addition, the heating element 121 is preferably arranged at the bottom end of the first support part, which can not only uniformly heat the liquid in the first support part as a whole, but also support the flexible first support part to avoid the problem of the middle area of ​​the first support part being concave downward (that is, it can maintain stable contact between the liquid and the base column).

[0057] From another perspective, the present invention adopts multiple technical means such as directly arranging liquid raw materials along the length direction of the base column, a first support part made of flexible material for supplying liquid, and a heating element arranged at the lower end of the first support part along the length direction, which coordinates to provide a safe (avoiding damage to the grown material) and lightweight mobile system as a whole. Therefore, when growing and preparing multi-layer nerve conduits, this mobile system can reduce the difficulty of controlling the movement displacement accuracy through a lightweight intermediate mechanism, and at the same time, the flexible characteristics of the groove can reduce the damage to the existing nerve conduits on the base column during the contact process when the base column has accidental errors such as movement deviation.

[0058] Furthermore, the liquid surface supply method adopted by the mobile system enables the liquid to uniformly contact various positions of the base column at the same time, thereby facilitating the improvement of the uniformity of the formed columnar material and greatly reducing the growth time of the columnar material.

[0059] In other words, the present invention provides a method for preparing columnar materials by synchronously printing (or overall printing and integral molding) the structural layers.

[0060] In some embodiments, it also includes: a projection mechanism 13, the projection mechanism includes: an optical projector (also referred to as an optical machine), the optical projector is arranged above the base column to provide optical projection to the base column. For example, in some embodiments, the optical projector can be a projector based on CAL (Computed Axial Lithography). In some embodiments, the optical projector can also adopt a combined system with a 405nm laser, a scanning field mirror, and an xy scanning galvanometer. For another example, the optical projector can also be an optical machine based on DLP (Digital Light Processing), or an SLM (Selective laser melting) optical machine. In some embodiments, the raw material can be a photocurable solution.

[0061] In some embodiments, see Figure 7 As shown, the first support portion 7 includes: a liquid supply end 7b, on which the groove is arranged; both sides of the liquid supply end 7b are connected to the second base through support ends 7a respectively; wherein the height of the upper end surface of the support end 7a is lower than the height of the lateral opening of the groove, so that a certain operating space is reserved between the base column located outside the two ends of the groove, the lateral opening and the upper end surface of the support end 7a, so that the user can add liquid into the groove through the lateral operating space.

[0062] Especially during the printing process, adding liquid from the side can avoid affecting the nerve conduit that has been formed on the base column.

[0063] Furthermore, in some embodiments, the heating element 121 can be a plate with a certain length (such as a rectangular plate, on which a heating element, such as a heating wire, etc., is arranged), and its length is the same or similar to the length of the liquid supply end, so that the heating element 121 is arranged at the lower end of the liquid supply end 7b to uniformly heat the liquid at its upper end.

[0064] Alternatively, in some embodiments, the heating element may be a column having a certain length, on which a heating element such as a heating wire is disposed.

[0065] In some embodiments, at least a portion of the first support portion is made of a flexible material. For example, in some embodiments, at least the liquid supply end is made of a flexible material. For example, in some embodiments, at least the surface of the groove in the liquid supply end is made of a flexible material. In some embodiments, a heating plate can also be arranged on the side of the first support portion to heat the liquid in the first support portion and to support the first support portion. In some embodiments, the flexible material refers to a polymer material with a certain bending plasticity, for example, it can be a flexible plastic material, a flexible nano material, a flexible electronic material or a flexible capsule material, etc.

[0066] Flexible materials generally have the following properties: High elasticity: able to withstand large deformations without permanent damage. Softness: the material is soft to the touch and easy to bend and fold. Plasticity: can change shape by heating, pressure, etc., and maintain the new shape after cooling or pressure release. Durability: can maintain performance after repeated deformation. Adaptability: can adapt to different environmental conditions and usage requirements. For example, the flexible material selected in the present invention can be one or more of the following: rubber: natural rubber and synthetic rubber; silicone: has good high temperature resistance, low temperature resistance and biocompatibility; polyurethane; polyvinyl chloride (PVC). In some embodiments, the hardness of the flexible material ranges from 60A to 90A.

[0067] Preferably, in some embodiments, if the number of layers of columnar material is relatively small, it is possible to use Figure 1-Figure 6 A rotary printing device is shown. The rotary printing device includes: A first base 1, on which a first driving mechanism 2, such as a motor, is disposed; a first bracket 3; and a first clamping head 6, the first clamping head 6 is arranged on the first bracket 3 to be fixed by the first bracket 3, and the first end of the first clamping head 6 is connected to the output end of the first driving mechanism 2, and the second end of the first clamping head 6 is used to fix / lead out the base column (or the first clamping head is used to fix the first end of the base column); the base column has a columnar surface, and the columnar surface is used to provide a molding platform for the liquid; A second bracket 4, and a second clamping head 9, wherein the second clamping head 9 is arranged on the second bracket 4, and the second clamping head 9 is used to fix the second end of the base column; The second base 5 is provided with a first supporting portion 7 , and the first supporting portion 7 is provided with a groove 71 matched with the shape of the base column.

[0068] For example, in some embodiments, the cross-sectional structure of the groove is semicircular.

[0069] In some embodiments, the first supporting portion is preferably made of a flexible material, and correspondingly, the intermediate mechanism further includes: a second supporting portion, and the second supporting portion is used to support the first supporting portion.

[0070] For example, in some embodiments, see Figure 1-Figure 2 As shown, the second supporting portion is a bridge-shaped bracket 8 arranged at the lower side of the first supporting portion, and the bridge-shaped bracket 8 is arranged in a direction perpendicular to or intersecting with the axial direction of the first supporting portion.

[0071] For example, in some embodiments, see Figure 6 As shown, the second support portion can also be a reinforcement member 73 arranged on the lower side of both ends of the first support portion 7, and the two reinforcement members 73 are connected to form an arched area on the lower side of the first support portion 7 (or, it is arranged in an "arch bridge shape").

[0072] Preferably, in some embodiments, the shape or size of the tank can be flexibly set according to the preparation requirements of the columnar material. Taking the nerve catheter as an example, it is customized according to clinical needs. The height, weight, age, gender and injury site of different patients will affect the thickness and length of the nerve, so it needs to be measured and customized every time. Therefore, the diameter range of the tank can be designed according to the inner diameter of the nerve and the thickness of the catheter, and the thickness of the catheter can be determined by comprehensive consideration of mechanics and degradation.

[0073] Preferably, the diameter of the base column is customized according to clinical needs, requiring it to be made of stainless steel, conductive, straight and stiff, with smooth tube walls, etc.

[0074] Preferably, the surface of the groove 71 is made of an elastic material to reduce the friction of the contact surface. The present invention preferably uses TPU material with a hardness range of 60~90A and a printing temperature of 195~205°C. The groove setting has the advantages of wear resistance, corrosion resistance, strong elasticity, and low production cost. The "arch bridge" structure designed by the present invention can strengthen the base while maintaining the advantages of TPU material.

[0075] The following is an explanation of the workflow of the above printing device using an exemplary printing process (the picture in this embodiment is equivalent to the above second slice image): First, design the structural layer (such as slice layer) to be formed by rotating the base column once (360°) and the corresponding image sequence (or directly create the sequence without the model). The sequence contains n images. The rotation speed of the column is v (° / s). The projection time of a single projection image on the column is t. s =360 / (n×v)(s).

[0076] The next step is to evenly adsorb an appropriate amount of photocurable liquid on the outer surface of the base column. At the same time, for composite printing materials, heating treatment can also be performed to maintain the activity of the composite printing materials.

[0077] After a period of uniform rotation and constant light intensity exposure (e.g., the time for one rotation is set to T), the thickness of the structure layer formed after the outer layer of the cylinder with a diameter of d is exposed by rotation is related to the total projection time T (s) and the light intensity I (mW / cm²). For a single light machine that exposes one layer of the cylinder and the cylinder itself is opaque, only one side is irradiated at any time, so the final dose received is approximately Δ =1 / 2×T×I, because the layer thickness is usually thin, at the millimeter level.

[0078] The applicant comprehensively considers the attenuation of light before and after the above-mentioned materials are cured, and believes that there is an approximate relationship between the formed outer layer cross-sectional area (regarded as a ring) S and the dose Δ: .

[0079] Furthermore, in order to reduce the amount of preparation work and quickly complete the printing preparation of new products (such as columnar materials of different raw materials or different sizes), the present invention also provides a preparation method applicable to the above-mentioned rotary printing device as follows: S100 provides a columnar material preparation device for printing a columnar material, the columnar material preparation device comprising: a base column for guiding a raw material to grow the columnar material thereon, the base column having a diameter; at least one optical machine (or projector) arranged toward the base column; S101 acquires printing condition data, wherein the printing condition data includes first type data; the first type data includes one or more of the following: thickness, adsorption performance (ie, adsorption), and initiator concentration; Among them, thickness refers to the thickness of the slice to be printed, adsorption performance refers to the adsorption capacity of the base column to the liquid (or ink), and initiator concentration refers to the concentration of the initiator in the liquid; For example, in some embodiments, when a new nerve conduit product needs to be printed, the user can comprehensively determine the current printing parameters (such as printing time, light intensity, or applicable base column) based on the customization requirements of the nerve conduit (i.e., thickness) and the characteristics of the existing raw materials (i.e., adsorption performance, initiator concentration).

[0080] S102: querying the matching historical printing data from the historical database through the printing condition data, wherein the historical database includes multiple groups of the historical printing data, wherein one group of the historical printing data includes: the first type of data, and the second type of data, wherein the second type of data includes: time (i.e., the time required for the base column to rotate one circle), light intensity (i.e., the light intensity of the projector), and diameter (i.e., the diameter of the base column); For example, in some embodiments, each time the printing of a nerve conduit is completed, relevant data in the printing process will be collected to obtain a set of historical printing data.

[0081] For example, in some embodiments, the relevant data in the printing process is continuously collected, and the historical database can be continuously updated to enhance the reference application value of the historical database.

[0082] Wherein, S102 comprises the steps of: using a first query rule to query from the history database to obtain at least one corresponding set of the history printing data; the first query rule requires that the printing condition data and at least two items of the first type of data in the history printing data meet a preset matching rule, and the matching rule requires that the difference between the corresponding two values ​​belongs to a corresponding set first threshold range; For example, in some embodiments, when the difference between the thickness in the printing condition data and the thickness in the historical printing data belongs to the first sub-range, the two are considered to match; for example, in some embodiments, when the difference between the adsorption performance in the printing condition data and the adsorption performance in the historical printing data belongs to the second sub-range, the two are considered to match. For example, in some embodiments, when the difference between the initiator concentration in the printing condition data and the initiator concentration in the historical printing data belongs to the third sub-range, the two are considered to match.

[0083] Preferably, in some embodiments, when the difference between the corresponding two numerical values ​​belongs to the corresponding set first threshold range, the two numerical values ​​refer to thickness and adsorption performance, or the two numerical values ​​refer to thickness and initiator concentration.

[0084] S103 uses the at least one set of historical printing data found to predict corresponding fitting coefficients through a set printing prediction model (or fitting model); the printing prediction model is: ;in, is the thickness, is the fitting coefficient, For the time, is the light intensity, is the diameter; For example, in some embodiments, multiple fitting coefficients can be selected through multiple groups of historical printing data, and the final predicted fitting coefficient can be an average value of the multiple fitting coefficients.

[0085] For another example, in some embodiments, multiple groups of historical printing data may be fitted by means of function fitting, so as to determine the final value of the fitting coefficient by means of the fitting function.

[0086] S104: using the printing condition data and the fitting coefficient to predict the second type of data that meets the current printing condition data through the printing prediction model.

[0087] The applicant noted that printing parameters (such as printing time, light intensity, etc.) will have a significant impact on the growth and final quality of the nerve conduit, and that the printing parameters need to be adaptively adjusted for different types of customized nerve conduits. Therefore, when faced with large-scale production of nerve conduits, or whenever a new customized nerve conduit needs to be prepared, the problem of parameter selection will be faced, and this parameter selection process will also extend the preparation cycle of the nerve conduit.

[0088] In order to reduce the workload in the parameter selection process, the present invention proposes a method for quickly screening out recommended fitting parameters. Specifically, the present invention constructs a printing prediction model by comprehensively selecting equipment parameters such as light intensity and time, and product parameters such as diameter, wherein the product parameters can be independently set by the user in combination with customized standards, and then the relative relationship between printing light intensity and time can be predicted and derived by combining the set product parameters with the fitting coefficient, thereby assisting the user to quickly set the light intensity or time that meets the conditions.

[0089] Furthermore, the present invention selects product parameters - thickness, printing liquid characteristics (such as adsorption performance or initiator concentration) as key matching factors, so as to comprehensively select historical printing data that meets the current printing conditions through product parameters and liquid characteristics, and directly combine the historical printing data to predict the corresponding fitting coefficients through the printing prediction model. The final user can first set the printing parameters through the predicted fitting coefficients. The prediction of the fitting coefficients can reduce the testing workload that the user needs to do before formal printing. Among them, by reasonably setting the printing light intensity and printing time (printing time further limits the rotation speed of the base column), it is ensured that at the appropriate printing time, the liquid can be evenly coated on the surface of the base column, and at the same time, the liquid will not be separated due to excessive rotation speed.

[0090] In some embodiments, the steps are also included: S105 using the second type of data predicted in S104 to perform at least one test; S106 recording the test printing data during the test, the test printing data including: the thickness, the time, the light intensity, and the diameter; S107 obtaining the fitting coefficient by fitting the printing prediction model according to the test printing data; S108 determining whether the difference between the fitting coefficient in S107 and the fitting coefficient in S103 belongs to the set second threshold range; if so, using the fitting coefficient in S107 and / or the fitting coefficient in S103 as the recommended fitting coefficient.

[0091] In this embodiment, during actual production (especially before mass production), a comprehensive evaluation can be conducted between at least one test printing result and the predicted fitting coefficient to verify the selected fitting coefficient again. If the two results are similar, the recommended result is considered to be more reliable and suitable for promotion to formal production.

[0092] Furthermore, in some embodiments, the user can select a better fitting coefficient from the fitting coefficient in S107 and the fitting coefficient in S103 based on the actual comparison results and work experience. Therefore, the fitting coefficient recommendation method in this embodiment can reduce the number of tests that the user needs to perform in the process of exploring parameters to a certain extent, and reduce the workload in the process of parameter wear.

[0093] In some embodiments, the printing condition data further includes: time or light intensity.

[0094] The columnar material preparation method provided by the present invention is particularly suitable for printing columnar objects with multiple structural layers. Specifically, the preparation process is: first, identify multiple structural layers of the columnar object; for each structural layer, create a corresponding printing model, and cut out multiple images to be projected according to the printing model; rotate the base column so that the projector projects the images onto the base column according to the set time and order, so as to form a multi-layer columnar object with a specific pattern structure.

[0095] Embodiment 2 Correspondingly, the present invention also provides a columnar material preparation system (or a rotary printing system), comprising: A printing condition acquisition module, used to acquire printing condition data, wherein the printing condition data includes first type data; the first type data includes one or more of the following: thickness, adsorption performance, initiator concentration; A query module, used for querying matching historical printing data from a historical database through the printing condition data, wherein the historical database includes a plurality of groups of the historical printing data, wherein one group of the historical printing data includes: the first type of data, and the second type of data, wherein the second type of data includes: time, light intensity, and diameter; wherein the query module is used for querying and obtaining corresponding at least one group of the historical printing data from the historical database using a first query rule; the first query rule requires that the printing condition data and at least two items of the first type of data in the historical printing data meet a preset matching rule, and the matching rule requires that the difference between the corresponding two values ​​belongs to a corresponding set first threshold range; The first prediction module is used to predict the corresponding fitting coefficient by using at least one set of the historical printing data obtained through the set printing prediction model; the printing prediction model is: ;in, is the thickness, is the fitting coefficient, For the time, is the light intensity, is the diameter; The second prediction module uses the printing condition data and the fitting coefficient to predict the second type of data that meets the current printing condition data through the printing prediction model.

[0096] Furthermore, the system further comprises: A test input module, used for recording test printing data in the test process when at least one test is performed using the second type of data predicted by the first prediction module, the test printing data including: the thickness, the time, the light intensity, and the diameter; A second prediction module, configured to obtain the fitting coefficient by fitting the print prediction model according to the test print data; A judgment module is used to judge whether the difference between the fitting coefficient in the second prediction module and the fitting coefficient in the first prediction module belongs to a set second threshold range; if so, the fitting coefficient in the second prediction module and / or the fitting coefficient in the first prediction module are used as recommended fitting coefficients.

[0097] The rotary printing system in the present invention can implement the method steps in any of the above embodiments, which will not be described in detail here.

[0098] Further, in some embodiments, the first data type may also include one or more of the following: the number of images n to be projected by the projector when printing a layer of nerve conduit: affecting the printing accuracy of the angular distribution of the cylinder. The resolution of the projector: affecting the printing accuracy of the axial distribution of the base column; the material ratio of the liquid: such as the physical and chemical properties of electrospinning, the components of the gel material (such as colorants, initiators); the base column and the groove: the light transmittance, roughness, rigidity, toughness, etc. of the base column, the shape, depth and width of the groove used for filling materials, etc.

[0099] It should be noted that the columnar object (or columnar material) prepared in the present invention refers to a columnar structure with a certain length, and the columnar structure can be solid or hollow. For example, various columnar objects such as nerve conduits, pipes (such as plastic pipes) can be prepared according to different types of raw materials.

[0100] It should be noted that, in this article, the term "includes", "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "includes a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element. Through the description of the above implementation mode, a person skilled in the art can clearly understand that the above-mentioned embodiment method can be implemented by means of software plus a necessary general hardware platform, and of course, it can also be implemented by hardware, but in many cases the former is a better implementation mode. Based on such an understanding, the technical solution of the present invention is essentially or the part that contributes to the prior art can be embodied in the form of a software product, which is stored in a storage medium (such as ROM / RAM, disk, CD), and includes several instructions to enable a computer terminal (which can be a mobile phone, computer, server, or network equipment, etc.) to execute the methods described in each embodiment of the present invention. The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A method for preparing a columnar material, characterized in that: The method comprises: S001, obtaining a three-dimensional digital model of the columnar material; S002, performing layered slicing processing on the three-dimensional digital model along the thickness direction to obtain corresponding multi-layer slices; S003, acquiring a first slice image adapted to the preparation device of the columnar material according to the slice; wherein the preparation device comprises: a base column, and the base column is configured to be rotatable around its axial direction, the base column has a diameter and a working length, and the outer surface of the base column can absorb a photocurable liquid layer of a certain thickness; an optical machine, used to project a digital light beam onto the outer surface of the base column, and the area of ​​the base column effectively covered by the digital light beam is the projection working area; correspondingly, the first slice image is a pattern corresponding to the slice after spreading, and the height of the first slice image matches the circumference of the base column, and the width of the first slice image matches the working length; S004, using a set segmentation method to segment and acquire a plurality of second slice images along the width direction of the first slice image, wherein the set segmentation method requires that the height of the second slice image matches the height of the projection work area, and the second slice images are associated with a corresponding projection order; S005, the base column rotates at a set rotation speed, so that the second slice image is projected onto the outer surface of the base column in sequence according to the projection order, so that the photocurable liquid is formed in sequence according to the pattern on the second slice image under the projection of the corresponding digital light beam.

2. The method for preparing a columnar material according to claim 1, characterized in that: The number of pixel rows of the first slice image satisfies a set slicing rule, and the slicing rule includes: ； ； ； ； ； in, n max is the maximum number of pixel rows in the height direction of the first slice image, N H 、Nw are the maximum number of pixels of the projection working area of ​​the digital light beam in the height direction and the width direction respectively; H p 、W p point are respectively the height and width of the projection working area of ​​the digital light beam; l is the working length, h p is the circumference of the base column, d is the diameter.

3. The method for preparing a columnar material according to claim 2, characterized in that: The thickness of a slice is , correspondingly, the pixel height of the first slice image of the first layer projected on the base column is ;No. The maximum pixel height of the first slice image of the layer is .

4. The method for preparing a columnar material according to claim 2, characterized in that: The first slice image is a grayscale image or a binary image. Correspondingly, the S004 includes: Extracting the lines composed of each row of pixels of the first slice image as subsets in sequence, wherein the black pixels are identified as the background of the second slice image, and the non-black pixels are identified as the pattern of the second slice image; A plurality of second slice images are created respectively according to the black pixels and the non-black pixels.

5. The method for preparing a columnar material according to claim 4, characterized in that: The total number of the second slice images formed corresponding to the multiple slices is: ； m is the number of slices, is the thickness of one slice, n total is the total number of the second slice images of the three-dimensional digital model, n i For the i The total number of the second slice images of the slice layer.

6. The method for preparing a columnar material according to claim 1, characterized in that: Also includes the steps: S006, monitoring the photocuring efficiency of the photocurable liquid; S007, when the light curing efficiency is less than the set light curing efficiency, the second slice image and the projection delay are corrected, wherein the projection delay refers to the time that a single second slice image stays on the base column, and the step of correcting the second slice image and the projection delay includes: At least two of the second slice images of the slice of the layer to be corrected are merged to obtain a corrected slice image; wherein the layer to be corrected is the first i layer, and the corresponding height of the corrected slice image is ; The projection delay is determined according to the modified slice image, and the projection delay is: , n i For the i the total number of the corrected slice images of the slices of the layer to be corrected, is the rotation speed.

7. The method for preparing a columnar material according to claim 5, characterized in that: S005 also includes the steps of: The printing conditions of the three-dimensional digital model are selected according to the fitting model; wherein the printing conditions include: the thickness of the slice, the printing time of one layer of the slice, the light intensity, and the diameter of the base column; the fitting model includes: ;in, is the thickness, is the fitting coefficient, is the printing time, is the light intensity, is the diameter.

8. A system for preparing columnar materials, characterized in that: The system comprises: A model acquisition module, used to acquire a three-dimensional digital model of the columnar material; A slicing module, used for performing layered slicing processing on the three-dimensional digital model along the thickness direction to obtain multi-layer slices; A first image acquisition module is used to acquire a first slice image adapted to the preparation device of the columnar material according to the slice; wherein the preparation device comprises: a base column, and the base column is configured to be rotatable around its axial direction, the base column has a diameter and a working length, and the outer surface of the base column can absorb a certain thickness of photocurable liquid; an optical machine is used to project a digital light beam onto the surface of the base column, and the area of ​​the base column effectively covered by the digital light beam is the projection working area; correspondingly, the first slice image is a pattern corresponding to the slice after spreading, and the height of the first slice image matches the circumference of the base column, and the width of the first slice image matches the working length; A second image acquisition module, used to segment and acquire a plurality of second slice images along the width direction of the first slice image using a set segmentation method, wherein the set segmentation method requires that the height of the second slice image matches the projection work area, and the second slice image is associated with a corresponding projection order; The printing module is used to control the base column to rotate at a set rotation speed, so that the second slice image is projected onto the outer surface of the base column in sequence according to the projection order, so that the photocurable liquid is formed in sequence according to the pattern on the second slice image under the projection of the corresponding digital light beam.

9. A preparation device for columnar materials, characterized in that: include: A base column, wherein the base column has a diameter and a length, and the base column has a curved outer surface; A sample loading element, the sample loading element being capable of containing a light-curable liquid; Wherein, the sample adding element has a sample adding pool for containing the photocurable liquid, and the base column is arranged so that the outer surface can be at least partially immersed in the photocurable liquid; or, the sample adding element has at least one nozzle, and the nozzle can spray the photocurable liquid on the outer surface; A supporting element, the supporting element is used to support the base column, and can drive the base column to rotate around its axial direction at a set speed, and the base column can adsorb and form a photocurable liquid layer with a certain thickness on the outer surface during the rotation process; An optical machine, used for projecting a digital light beam onto the surface of the base column; a first distance exists between the projection end of the optical machine and the surface of the base column at the initial printing moment; A moving element, wherein the moving element is used to drive the base column to move along the projection direction; wherein, when the base column grows a structural layer having a first thickness, the moving element can drive the base column to move so that the distance between the projection end and the outer surface is maintained at or approximately equal to the first distance.

10. The preparation device of columnar material according to claim 9, characterized in that: Also includes: A heating device, the heating device is used to heat the base column and / or the sample loading pool; And / or, the preparation equipment further includes: a photographing device, wherein the photographing device is used to collect image information of the base column.

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