Adjusting system and method for cell culture box

Abstract

The invention relates to the technical field of cell culture, and particularly provides an adjusting system and method for a cell incubator, and the system comprises a clean gas supply assembly which comprises a first gas driving assembly and a filtering assembly; a first temperature acquisition assembly; a second temperature acquisition assembly; a first humidity acquisition assembly; the controller is used for controlling the first gas driving assembly to drive external air to flow into the cell culture box when the in-box temperature information is smaller than a preset temperature lower limit value, the environment temperature information is larger than the in-box temperature information and the environment humidity information is smaller than a preset humidity upper limit value; the controller is also used for controlling the first gas driving assembly to drive external air to flow into the cell culture box when the in-box temperature information is greater than a preset temperature upper limit value, the environment temperature information is smaller than the in-box temperature information and the environment humidity information is smaller than a preset humidity upper limit value; according to the system, the energy consumption and the temperature regulation cost of the cell culture box are effectively reduced.

Description

Technical Field

[0001] The present application relates to the field of cell culture technology, and in particular, to a regulation system and method for a cell culture box. Background Art

[0002] In the field of cell culture technology, it is necessary to place the sample to be cultured in a cell culture incubator for culture and proliferation. The relevant cell culture incubator is provided with a temperature control component for raising or lowering the temperature in the cell culture incubator and a gas circulation component for forming a circulating airflow in the cell culture incubator. When the temperature in the cell culture incubator is lower than the preset lower temperature limit or the temperature in the cell culture incubator is higher than the preset upper temperature limit, the relevant technology can only rely on the cooperation of the temperature control component and the gas circulation component to adjust the temperature in the cell culture incubator as a whole, that is, the cold or heat required to adjust the temperature in the cell culture incubator is generated by the temperature control component. Therefore, the relevant technology has the problems of high energy consumption and high temperature adjustment cost of the cell culture incubator.

[0003] There is no effective technical solution to the above problems. It should be noted that the above information disclosed in this section is only used to understand the background of the present invention, and therefore may contain information that does not constitute prior art. Summary of the invention

[0004] The purpose of the present application is to provide a regulation system and method for a cell culture incubator, which can effectively reduce the energy consumption and temperature regulation cost of the cell culture incubator.

[0005] In a first aspect, the present application provides a regulation system for a cell culture incubator, comprising: A clean gas delivery assembly is installed on the cell culture box, comprising a first gas driving assembly and a filter assembly, wherein the first gas driving assembly is used to drive external air to flow into the cell culture box, and the filter assembly is used to filter the air flowing into the cell culture box; A first temperature collection component is used to collect ambient temperature information; The second temperature collection component is used to collect the temperature information in the box; A first humidity collection component is used to collect environmental humidity information; The controller is used to control the first gas driving component to drive the outside air to flow into the cell culture box when the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, so as to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to the first preset temperature threshold. The controller is also used to control the first gas driving component to drive the outside air to flow into the cell culture box when the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, so as to perform external circulation to cool the cell culture box until the temperature information in the box is less than or equal to the preset temperature upper limit or the difference between the temperature information in the box and the ambient temperature information is less than or equal to the second preset temperature threshold.

[0006] The present application provides a regulating system for a cell culture incubator, which can use outside air with a temperature greater than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low, and use outside air with a temperature less than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to adjust the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and the temperature control component together, that is, the present application can effectively reduce the cold or heat required to be generated by the temperature control component when adjusting the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature control cost of the cell culture incubator.

[0007] Optionally, the cell culture incubator also includes a temperature control module, which is used to adjust the temperature inside the cell culture incubator. The controller is also used to control the temperature control module to increase the temperature inside the cell culture incubator when the cell culture incubator is subjected to external circulation to heat up the cell culture incubator, or to control the temperature control module to lower the temperature inside the cell culture incubator when the cell culture incubator is subjected to external circulation to cool down the cell culture incubator.

[0008] Since when the cell culture incubator is heated by external circulation, the technical solution controls the temperature control module to increase the temperature inside the cell culture incubator, and when the cell culture incubator is cooled by external circulation, the technical solution controls the temperature control module to lower the temperature inside the cell culture incubator, that is, when the cell culture incubator is heated or cooled by external circulation, the technical solution can simultaneously use the outside air and the temperature control module to adjust the temperature inside the cell culture incubator. Therefore, the technical solution can effectively shorten the time required to increase the temperature information inside the box to a value greater than or equal to the preset temperature lower limit or to decrease it to a value less than or equal to the preset temperature upper limit, that is, the technical solution can effectively improve the temperature regulation efficiency of the cell culture incubator.

[0009] Optionally, the temperature control module is a semiconductor temperature control component.

[0010] Optionally, the clean gas supply component also includes a heating module, and the regulation system for the cell culture incubator also includes a third temperature acquisition component, which is used to collect outlet temperature information, and the outlet temperature information is the temperature of the outlet of the clean gas supply component. The controller is also used to control the heating module to heat the air flowing into the cell culture incubator when the cell culture incubator is subjected to external circulation and the outlet temperature information is less than a preset heating temperature, until the outlet temperature information reaches a preset heating temperature, and the preset heating temperature is less than a preset temperature lower limit.

[0011] This technical solution is equivalent to first using the heating module and the temperature control module to quickly increase the temperature in the cell culture incubator to near the preset temperature lower limit, and then using the temperature control module to accurately increase the temperature in the cell culture incubator to a value greater than or equal to the preset temperature lower limit when the temperature in the cell culture incubator is too low and the outlet temperature information is less than the preset heating temperature. Therefore, this technical solution can effectively improve the heating efficiency in the cell culture incubator and effectively avoid the situation where the temperature information in the cell culture incubator is greater than the preset temperature upper limit due to the rapid temperature increase in the cell culture incubator.

[0012] Optionally, the regulation system for the cell culture incubator also includes a humidity regulation module and a second humidity collection component, the humidity regulation module is used to increase or decrease the humidity in the cell culture incubator, the second humidity collection component is used to collect humidity information in the incubator, and the controller is also used to control the humidity regulation module to increase the humidity in the cell culture incubator when the humidity information in the incubator is less than a preset humidity lower limit value, until the humidity information in the incubator is greater than or equal to the preset humidity lower limit value, and the controller is also used to control the humidity regulation module to lower the humidity in the cell culture incubator when the humidity information in the incubator is greater than a preset humidity upper limit value, until the humidity information in the incubator is less than or equal to the preset humidity upper limit value.

[0013] This technical solution is equivalent to making the humidity information in the box greater than or equal to the preset humidity lower limit and less than or equal to the preset humidity upper limit through the cooperation of the humidity adjustment module and the second humidity collection component. Therefore, this technical solution can effectively avoid the situation where the culture and proliferation of the samples to be cultured are affected due to the humidity in the cell culture incubator being too high or too low.

[0014] Optionally, the humidity regulating module includes a humidification module and a condensation module, the humidification module is used to increase the humidity in the cell culture incubator, and the condensation module is used to reduce the humidity in the cell culture incubator by condensing water vapor in the cell culture incubator.

[0015] Optionally, when the temperature information in the box is less than a preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than a preset humidity upper limit, the process of controlling the first gas driving component to drive external air to flow into the cell culture box includes: When the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity lower limit, controlling the first gas driving component to drive the outside air to flow into the cell culture box; When the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, the process of controlling the first gas driving component to drive the outside air to flow into the cell culture box includes: When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity lower limit, the first gas driving component is controlled to drive external air to flow into the cell culture box.

[0016] Since this technical solution is equivalent to using external air to heat up or cool down the cell culture incubator for dehumidification, and the water vapor in the cell culture incubator can be discharged from the cell culture incubator under the action of the first gas driving component, this technical solution can effectively reduce the situation of using the condensation module to dehumidify the cell culture incubator, thereby avoiding as much as possible the situation where the condensed water generated when the condensation module dehumidifies the cell culture incubator breeds bacteria and causes contamination of the samples to be cultured.

[0017] Optionally, the regulation system for the cell culture incubator also includes a second gas drive component, the air inlet and air outlet of the second gas drive component are both connected to the cell culture incubator, the second gas drive component is used to drive the gas circulation flow in the cell culture incubator, and the controller is also used to control the second gas drive component to drive the gas circulation flow in the cell culture incubator when the first gas drive component stops working.

[0018] Since the second gas drive component of the technical solution can drive the gas circulation in the cell culture incubator when the first gas drive component stops working, so as to make the temperature and humidity distribution in the cell culture incubator uniform, the technical solution can effectively avoid the situation where the culture and proliferation of the sample to be cultured is affected due to the uneven temperature and humidity distribution in the cell culture incubator.

[0019] Optionally, the gas outlet end of the second gas driving component is connected to the cell culture box through a flow homogenizing component.

[0020] In a second aspect, the present application further provides a method for regulating a cell culture incubator, which is applied to the regulating system for a cell culture incubator provided in the first aspect above. The method for regulating a cell culture incubator comprises the following steps: S1. When the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, control the first gas driving component to drive the outside air to flow into the cell culture box to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to the first preset temperature threshold; S2. When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity upper limit, control the first gas driving component to drive the outside air to flow into the cell culture box to perform external circulation cooling on the cell culture box until the temperature information inside the box is less than or equal to the preset temperature upper limit or the difference between the temperature information inside the box and the ambient temperature information is less than or equal to the second preset temperature threshold.

[0021] The present application provides a regulation method for a cell culture incubator, which can use outside air with a temperature greater than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low, and use outside air with a temperature less than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to regulate the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and a temperature control component. That is, the present application can effectively reduce the cold or heat required to be generated by the temperature control component when regulating the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature regulation cost of the cell culture incubator.

[0022] From the above, it can be seen that the present application provides a regulation system and method for a cell culture incubator, which can use the outside air whose temperature is greater than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low, and use the outside air whose temperature is less than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to adjust the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and the temperature control component together, that is, the present application can effectively reduce the cold or heat that the temperature control component needs to generate when adjusting the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature control cost of the cell culture incubator. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 A control relationship diagram of a regulating system for a cell culture incubator is provided for an embodiment of the present application.

[0024] Figure 2A flow chart of a method for adjusting a cell culture incubator provided in an embodiment of the present application.

[0025] Figure numerals: 1. Temperature control module; 2. Clean gas supply component; 3. First temperature collection component; 4. Second temperature collection component; 5. First humidity collection component; 6. Controller; 7. Heating module; 8. Humidity adjustment module; 9. Second humidity collection component; 10. Second gas drive component. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the application claimed for protection, but merely represents the selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application.

[0027] It should be noted that similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings. At the same time, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0028] First, as Figure 1 As shown, the present application provides a regulation system for a cell culture incubator, comprising: A clean gas delivery assembly 2 is installed on the cell culture box, and includes a first gas driving assembly and a filtering assembly. The first gas driving assembly is used to drive the outside air to flow into the cell culture box, and the filtering assembly is used to filter the air flowing into the cell culture box. The first temperature collection component 3 is used to collect ambient temperature information; The second temperature collection component 4 is used to collect the temperature information in the box; A first humidity collection component 5, used for collecting environmental humidity information; Controller 6 is used to control the first gas driving component to drive outside air to flow into the cell culture box when the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, so as to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to the first preset temperature threshold. It is also used to control the first gas driving component to drive outside air to flow into the cell culture box when the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, so as to perform external circulation to cool the cell culture box until the temperature information in the box is less than or equal to the preset temperature upper limit or the difference between the temperature information in the box and the ambient temperature information is less than or equal to the second preset temperature threshold.

[0029] Among them, this embodiment provides a regulation system for a cell culture incubator, which is used in a cell culture incubator. The cell culture incubator is provided with a culture chamber and a chamber door for placing samples to be cultured (samples that need to be cultured and proliferated). The system can adjust the temperature in the cell culture incubator (equivalent to adjusting the temperature in the culture chamber). This embodiment can connect the culture chamber with the outside world by opening the chamber door and isolate the culture chamber from the outside world by closing the chamber door. Specifically, when the chamber door is opened, this embodiment can place the sample to be cultured into the culture chamber or take the cultured sample (the sample that has completed culture and proliferation) out of the culture chamber. During the culture and proliferation process, the chamber door remains closed. Preferably, this embodiment can monitor the switch status of the chamber door by setting a micro switch or a Hall sensor at the chamber door. The clean gas supply component 2 of this embodiment includes a first gas drive component and a filter component. The first gas drive component is preferably a fan. The air inlet end of the first gas drive component is connected to the outside world, and the air outlet end of the first gas drive component is connected to the cell culture box. The filter component filters and sterilizes the air flowing into the cell culture box. It should be understood that the airway of the clean gas supply component 2 of this embodiment can be independent of the airway of the existing gas circulation component, and the clean gas supply component 2 of this embodiment can also share an airway with the existing gas circulation component. The first temperature acquisition component 3 and the second temperature acquisition component 4 of this embodiment are preferably temperature sensors. The first temperature acquisition component 3 is used to collect environmental temperature information, which is equivalent to the temperature of the outside air. The second temperature acquisition component 4 is used to collect the temperature information in the box, which is the temperature in the cell culture box. The first humidity acquisition component 5 of this embodiment is preferably a humidity sensor. The first humidity acquisition component 5 is used to collect environmental humidity information, which is equivalent to the humidity of the outside air. It should be understood that since the air pressure in the cell culture incubator continues to rise when the first gas driving component drives the outside air to flow into the cell culture incubator, in order to avoid damage to the samples to be cultured or even safety accidents caused by excessive air pressure in the cell culture incubator, this embodiment is provided with a pressure relief valve in the cell culture incubator, which can discharge the gas in the cell culture incubator when the air pressure in the cell culture incubator is too high.

[0030] The controller 6 of this embodiment is electrically connected to the temperature control module 1, the first gas drive component, the first temperature acquisition component 3, the second temperature acquisition component 4 and the first humidity acquisition component 5. If the temperature information in the box is less than the preset temperature lower limit, it is considered that the temperature in the cell culture box is too low, and the temperature in the cell culture box needs to be increased. If the temperature information in the box is greater than the preset temperature upper limit, it is considered that the temperature in the cell culture box is too high, and the temperature in the cell culture box needs to be lowered. The preset humidity upper limit of this embodiment is a value converted based on the target humidity upper limit of the cell culture box (the maximum value of the relative humidity in the cell culture box). Since the humidity of the outside air flowing into the cell culture box is less than the preset humidity upper limit, this embodiment can effectively avoid the situation where the humidity in the cell culture box is too high (the relative humidity in the cell culture box is greater than the target humidity upper limit) due to the excessive humidity of the outside air flowing into the cell culture box. It should be understood that, since the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, this embodiment controls the first gas drive component to drive the outside air to flow into the cell culture box. Therefore, this embodiment is equivalent to using the outside air with a temperature greater than the temperature information in the box and a humidity less than the preset humidity upper limit to heat the cell culture box by external circulation when the temperature in the cell culture box is too low. Since the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, this embodiment controls the first gas drive component to drive the outside air to flow into the cell culture box. Therefore, this embodiment is equivalent to using the outside air with a temperature less than the temperature information in the box and a humidity less than the preset humidity upper limit to cool the cell culture box by external circulation when the temperature in the cell culture box is too high. It should also be understood that the cell culture incubator of this embodiment further includes a temperature control module 1 and a gas circulation component, and the temperature control module 1 is equivalent to the existing temperature control component. When the temperature information in the incubator is less than the preset temperature lower limit, if the ambient temperature information is less than or equal to the temperature information in the incubator or the ambient humidity information is greater than or equal to the preset humidity upper limit, then this embodiment needs to increase the temperature of the cell culture incubator as a whole through the cooperation of the temperature control module 1 and the gas circulation component. When the temperature information in the incubator is greater than the preset temperature upper limit, if the ambient temperature information is greater than or equal to the temperature information in the incubator or the ambient humidity information is greater than or equal to the preset humidity upper limit, then this embodiment needs to lower the temperature of the cell culture incubator as a whole through the cooperation of the temperature control module 1 and the gas circulation component.

[0031] The present application provides a regulating system for a cell culture incubator, which can use outside air with a temperature greater than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low, and use outside air with a temperature less than the temperature information in the incubator and a humidity less than a preset humidity upper limit to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to adjust the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and the temperature control component together, that is, the present application can effectively reduce the cold or heat required to be generated by the temperature control component when adjusting the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature control cost of the cell culture incubator.

[0032] In some preferred embodiments, the cell culture incubator further comprises a temperature control module 1, which is used to adjust the temperature in the cell culture incubator, and the controller 6 is further used to control the temperature control module 1 to increase the temperature in the cell culture incubator when the cell culture incubator is subjected to external circulation heating, or to control the temperature control module 1 to reduce the temperature in the cell culture incubator when the cell culture incubator is subjected to external circulation cooling. The temperature control module 1 of this embodiment may be composed of an existing heating component (e.g., a heating wire) and a cooling component (e.g., a water cooling system), wherein the heating component is used to increase the temperature in the cell culture incubator, and the cooling component is used to reduce the temperature in the cell culture incubator. When the cell culture incubator is heated by external circulation, this embodiment controls the temperature control module 1 to increase the temperature inside the cell culture incubator, and when the cell culture incubator is cooled by external circulation, this embodiment controls the temperature control module 1 to reduce the temperature inside the cell culture incubator, that is, when the cell culture incubator is heated or cooled by external circulation, this embodiment can simultaneously use the outside air and the temperature control module 1 to adjust the temperature inside the cell culture incubator. Therefore, this embodiment can effectively shorten the time required to increase the temperature information inside the incubator to a value greater than or equal to the preset temperature lower limit or to decrease it to a value less than or equal to the preset temperature upper limit, that is, this embodiment can effectively improve the temperature regulation efficiency of the cell culture incubator. It should be understood that when the cell culture incubator is heated by external circulation, even if the ambient temperature information is less than the preset temperature lower limit, the embodiment can still use the temperature control module 1 to increase the temperature information in the incubator to a value greater than or equal to the preset temperature lower limit. When the ambient temperature information is less than the preset temperature lower limit, if the temperature information in the incubator is increased to the ambient temperature information, the outside air cannot continue to provide heat for the heating of the cell culture incubator, and as the temperature information in the incubator continues to increase, the outside air will provide cooling for the cell culture incubator. Therefore, when the temperature information in the incubator is greater than or equal to the ambient temperature information (the difference between the ambient temperature information and the temperature information in the incubator is less than or equal to 0), the embodiment needs to stop controlling the first gas driving component to drive the outside air to flow into the cell culture incubator, that is, the first preset temperature threshold of the above embodiment is 0 or Negative value, and when the cell culture incubator is cooled by external circulation, even if the ambient temperature information is greater than the preset temperature upper limit, this embodiment can still use the temperature control module 1 to reduce the temperature information in the box to less than or equal to the preset temperature upper limit. When the ambient temperature information is greater than the preset temperature lower limit, if the temperature information in the box is reduced to the ambient temperature information, the outside air cannot continue to provide cooling for the cell culture incubator, and as the temperature information in the box continues to decrease, the outside air will provide heat for the cell culture incubator. Therefore, when the temperature information in the box is less than or equal to the ambient temperature information (the difference between the temperature information in the box and the ambient temperature information is less than or equal to 0), this embodiment needs to stop controlling the first gas driving component to drive the outside air to flow into the cell culture incubator, that is, the second preset temperature threshold of the above embodiment is 0 or a negative value.Preferably, the start judgment condition of the temperature control module 1 of this embodiment is: the cell culture incubator is heated by external circulation and the ambient temperature information is less than the preset temperature lower limit value, or the cell culture incubator is cooled by external circulation and the ambient temperature information is greater than the preset temperature upper limit value. This embodiment is equivalent to controlling the temperature control module 1 to increase the temperature in the cell culture incubator only when the temperature in the cell culture incubator is too low and the temperature information in the incubator cannot be increased to a value greater than or equal to the preset temperature lower limit value (the ambient temperature information is less than the preset temperature lower limit value) by using only the outside air, and controlling the temperature control module 1 to decrease the temperature in the cell culture incubator only when the temperature in the cell culture incubator is too high and the temperature information in the incubator cannot be decreased to a value less than or equal to the preset temperature lower limit value (the ambient temperature information is greater than the preset temperature upper limit value) by using only the outside air. Therefore, this embodiment can effectively avoid the situation in which the temperature control module 1 is used to increase the temperature in the cell culture incubator when the cell culture incubator is heated by external circulation and the ambient temperature information is greater than or equal to the preset temperature lower limit value, or the temperature control module 1 is used to decrease the temperature in the cell culture incubator when the cell culture incubator is cooled by external circulation and the ambient temperature information is less than or equal to the preset temperature upper limit value, thereby further reducing the energy consumption and temperature regulation cost of the cell culture incubator.

[0033] In some preferred embodiments, the temperature control module 1 is a semiconductor temperature control component. Specifically, the semiconductor temperature control component of this embodiment has two working surfaces. When the semiconductor temperature control component is working, one of the working surfaces generates heat and the other working surface generates cold. Under the action of the Peltier effect, this embodiment can make the working surface that originally generates cold generate heat and the working surface that originally generates heat generate cold by changing the direction of the current. Therefore, this embodiment can increase or decrease the temperature in the cell culture incubator by making one working surface of the semiconductor temperature control component perform heat exchange with the cell culture incubator. Since this embodiment selects a semiconductor temperature control component as the temperature control module 1, and the semiconductor temperature control component has the advantage of high temperature control accuracy, this embodiment can effectively improve the temperature control accuracy of the cell culture incubator.

[0034] In some preferred embodiments, the clean gas supply assembly 2 further includes a heating module 7, and the regulating system for the cell culture incubator further includes a third temperature acquisition assembly, which is used to collect the outlet temperature information, and the outlet temperature information is the temperature of the outlet of the clean gas supply assembly 2. The controller 6 is also used to control the heating module 7 to heat the air flowing into the cell culture incubator when the cell culture incubator is subjected to external circulation and the outlet temperature information is less than the preset heating temperature, until the outlet temperature information reaches the preset heating temperature, and the preset heating temperature is less than the preset temperature lower limit. The heating module 7 of this embodiment can be a device that can provide heat, such as an electric heater, and the third temperature acquisition assembly of this embodiment is preferably a temperature sensor. This embodiment is equivalent to first using the heating module 7 and the temperature control module 1 to quickly raise the temperature in the cell culture box to near the preset temperature lower limit when the temperature in the cell culture box is too low and the outlet temperature information is less than the preset heating temperature, and then using the temperature control module 1 to accurately raise the temperature in the cell culture box to greater than or equal to the preset temperature lower limit. Therefore, this embodiment can effectively improve the heating efficiency in the cell culture box and effectively avoid the situation where the temperature information in the box is greater than the preset temperature upper limit due to the excessively fast temperature increase in the cell culture box. It should be understood that since this embodiment can use the heating module 7 to heat the air flowing into the cell culture box, even if the ambient temperature information is less than or equal to the box temperature information before the box temperature information rises to greater than or equal to the preset temperature lower limit, this embodiment can continue to control the first gas drive component to drive the outside air to flow into the cell culture box until the outlet temperature information reaches the preset heating temperature. It should also be understood that this embodiment controls the heating module 7 to heat the air flowing into the cell culture incubator only when the cell culture incubator is subjected to external circulation heating and the air outlet temperature information is less than the preset heating temperature, and one of the conditions for this embodiment to perform external circulation heating on the cell culture incubator is that the temperature information inside the incubator is less than the ambient temperature information. Therefore, when the temperature change is the same, even if this embodiment simultaneously utilizes the outside air, the heating module 7 and the temperature control module 1 to heat the cell culture incubator, the total heat generated by the heating module 7 and the temperature control module 1 is still less than the heat generated by the existing temperature control components.

[0035] In some preferred embodiments, the regulation system for the cell culture incubator further includes a humidity regulation module 8 and a second humidity collection component 9, the humidity regulation module 8 is used to increase or decrease the humidity in the cell culture incubator, the second humidity collection component 9 is used to collect humidity information in the incubator, and the controller 6 is also used to control the humidity regulation module 8 to increase the humidity in the cell culture incubator when the humidity information in the incubator is less than the preset humidity lower limit value, until the humidity information in the incubator is greater than or equal to the preset humidity lower limit value, and the controller 6 is also used to control the humidity regulation module 8 to reduce the humidity in the cell culture incubator when the humidity information in the incubator is greater than the preset humidity upper limit value, until the humidity information in the incubator is less than or equal to the preset humidity upper limit value. The second humidity collection component 9 of this embodiment is preferably a humidity sensor, and the second humidity collection component 9 is used to collect humidity information in the incubator, and the humidity information in the incubator is the humidity in the cell culture incubator. This embodiment is equivalent to making the humidity information in the box greater than or equal to the preset humidity lower limit and less than or equal to the preset humidity upper limit through the cooperation of the humidity adjustment module 8 and the second humidity collection component 9. Therefore, after completing the temperature adjustment of the cell culture incubator, if the humidity information in the box is less than the preset humidity lower limit, the humidity adjustment module 8 is controlled to increase the humidity in the cell culture incubator, that is, this embodiment is equivalent to first adjusting the temperature of the cell culture incubator and then adjusting the humidity of the cell culture incubator. This embodiment can also control the humidity adjustment module 8 to increase the humidity in the cell culture incubator when the temperature of the cell culture incubator is adjusted and the humidity information in the box is less than the preset humidity lower limit.

[0036] In some preferred embodiments, the humidity regulating module 8 includes a humidification module and a condensation module, wherein the humidification module is used to increase the humidity in the cell culture box, and the condensation module is used to reduce the humidity in the cell culture box by condensing the water vapor in the cell culture box. The humidification module of this embodiment can be a water tray with a heating component inside, and this embodiment can increase the evaporation rate of the water in the water tray by controlling the heating component to heat the water in the water tray, so as to increase the humidity in the cell culture box. Since the water vapor will condense when the temperature in the cell culture box is reduced, the water vapor and humidity in the cell culture box will both decrease. Therefore, the condensation module of this embodiment can condense the water vapor in the cell culture box by cooling the inside of the cell culture box, so as to reduce the humidity in the cell culture box.

[0037] In some preferred embodiments, when the temperature information in the box is less than a preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than a preset humidity upper limit, the process of controlling the first gas driving component to drive the outside air to flow into the cell culture box includes: When the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity lower limit, controlling the first gas driving component to drive the outside air to flow into the cell culture box; When the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, the process of controlling the first gas driving component to drive the outside air to flow into the cell culture box includes: When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity lower limit, the first gas driving component is controlled to drive external air to flow into the cell culture box.

[0038] Because when the humidity change is the same, the time required to dehumidify the cell culture incubator using the condensation module is greater than the time required to humidify the cell culture incubator using the humidification module, the condensed water generated when the condensation module dehumidifies the cell culture incubator has the risk of breeding bacteria, and the first gas drive component of this embodiment drives the outside air whose environmental humidity information is less than the preset humidity lower limit to flow into the cell culture incubator, that is, this embodiment is equivalent to heating or cooling the cell culture incubator with outside air, and the water vapor in the cell culture incubator can be discharged from the cell culture incubator under the action of the first gas drive component. Therefore, this embodiment can effectively reduce the situation of dehumidifying the cell culture incubator using the condensation module, thereby avoiding as much as possible the situation where the condensed water generated when the condensation module dehumidifies the cell culture incubator breeds bacteria and causes contamination of the samples to be cultured. It should be understood that since the first gas driving component of this embodiment drives the outside air whose environmental humidity information is less than the preset humidity lower limit value to flow into the cell culture incubator, the outside air will cause the humidity in the cell culture incubator to drop, while the humidity in the cell culture incubator needs to be greater than or equal to the preset humidity lower limit value and less than or equal to the preset humidity upper limit value. Therefore, during the process of the first gas driving component driving the outside air to flow into the cell culture incubator, the humidification module may need to work to ensure that the humidity in the cell culture incubator needs to be greater than or equal to the preset humidity lower limit value.

[0039] In some preferred embodiments, the regulating system for the cell culture incubator further includes a second gas drive assembly 10, the air inlet and air outlet of the second gas drive assembly 10 are both connected to the cell culture incubator, the second gas drive assembly 10 is used to drive the gas in the cell culture incubator to circulate, and the controller 6 is also used to control the second gas drive assembly 10 to drive the gas in the cell culture incubator to circulate when the first gas drive assembly stops working. The second gas drive assembly 10 of this embodiment is preferably a fan, because the second gas drive assembly 10 of this embodiment can drive the gas in the cell culture incubator to circulate when the first gas drive assembly stops working, so that the temperature and humidity in the cell culture incubator are evenly distributed, so this embodiment can effectively avoid the situation where the culture and proliferation of the sample to be cultured are affected due to the uneven distribution of temperature and humidity in the cell culture incubator.

[0040] In some preferred embodiments, the gas outlet of the second gas drive assembly 10 is connected to the cell culture box through a flow equalizer assembly. The flow equalizer assembly of this embodiment is preferably a flow equalizer plate. Since the gas outlet of the second gas drive assembly 10 of this embodiment is connected to the cell culture box through a flow equalizer assembly, this embodiment can effectively avoid the situation where the gas flowing out of the second gas drive assembly 10 forms turbulence in the cell culture box. Preferably, the gas outlet of the first gas drive assembly of this embodiment is also connected to the cell culture box through a flow equalizer assembly.

[0041] From the above, it can be seen that the regulation system for a cell culture incubator provided by the present application can use the outside air whose temperature is greater than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low; and use the outside air whose temperature is less than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to adjust the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and the temperature control component together. That is, the present application can effectively reduce the cold or heat that the temperature control component needs to generate when adjusting the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature control cost of the cell culture incubator.

[0042] Second, as Figure 2 As shown, the present application also provides a method for regulating a cell culture incubator, which is applied to the regulating system for a cell culture incubator provided in the first aspect above. The method for regulating a cell culture incubator comprises the following steps: S1. When the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, control the first gas driving component to drive the outside air to flow into the cell culture box to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to the first preset temperature threshold; S2. When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity upper limit, control the first gas driving component to drive the outside air to flow into the cell culture box to perform external circulation cooling on the cell culture box until the temperature information inside the box is less than or equal to the preset temperature upper limit or the difference between the temperature information inside the box and the ambient temperature information is less than or equal to the second preset temperature threshold.

[0043] An embodiment of the present application provides an adjustment method for a cell culture incubator, and the adjustment method for a cell culture incubator is applied to the adjustment system for a cell culture incubator provided in the first aspect. The principle of the adjustment method for a cell culture incubator provided in this embodiment is the same as the principle of the adjustment system for a cell culture incubator provided in the first aspect, and will not be discussed in detail here.

[0044] From the above, it can be seen that the present application provides a regulation system and method for a cell culture incubator, which can use the outside air whose temperature is greater than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to heat the cell culture incubator when the temperature in the cell culture incubator is too low, and use the outside air whose temperature is less than the temperature information in the box and whose humidity is less than the preset humidity upper limit value to perform external circulation to cool the cell culture incubator when the temperature in the cell culture incubator is too high. Therefore, the cold or heat required to adjust the temperature in the cell culture incubator can be provided by the outside air alone or by the outside air and the temperature control component together, that is, the present application can effectively reduce the cold or heat that the temperature control component needs to generate when adjusting the temperature in the cell culture incubator, thereby effectively reducing the energy consumption and temperature control cost of the cell culture incubator.

[0045] In the embodiments provided in the present application, it should be understood that, herein, relational terms such as first and second, etc. are merely used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0046] The above description is only an embodiment of the present application and is not intended to limit the protection scope of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A regulation system for a cell culture incubator, characterized in that: The regulating system for the cell culture incubator comprises: A clean gas supply assembly is installed on the cell culture box, comprising a first gas driving assembly and a filter assembly, wherein the first gas driving assembly is used to drive external air to flow into the cell culture box, and the filter assembly is used to filter the air flowing into the cell culture box; A first temperature collection component is used to collect ambient temperature information; The second temperature collection component is used to collect the temperature information in the box; A first humidity collection component is used to collect environmental humidity information; The controller is used to control the first gas driving component to drive outside air to flow into the cell culture box when the temperature information in the box is less than a preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than a preset humidity upper limit, so as to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to a first preset temperature threshold; and is also used to control the first gas driving component to drive outside air to flow into the cell culture box when the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, so as to perform external circulation to cool the cell culture box until the temperature information in the box is less than or equal to the preset temperature upper limit or the difference between the temperature information in the box and the ambient temperature information is less than or equal to a second preset temperature threshold.

2. The regulating system for a cell culture incubator according to claim 1, characterized in that: The cell culture incubator also includes a temperature control module, which is used to adjust the temperature inside the cell culture incubator. The controller is also used to control the temperature control module to increase the temperature inside the cell culture incubator when the cell culture incubator is subjected to external circulation to increase the temperature, or to control the temperature control module to reduce the temperature inside the cell culture incubator when the cell culture incubator is subjected to external circulation to reduce the temperature.

3. The regulating system for a cell culture incubator according to claim 2, characterized in that: The temperature control module is a semiconductor temperature control component.

4. The regulating system for a cell culture incubator according to claim 3, characterized in that: The clean gas supply component also includes a heating module, and the regulation system for the cell culture incubator also includes a third temperature acquisition component, and the third temperature acquisition component is used to collect air outlet temperature information, and the air outlet temperature information is the temperature of the air outlet of the clean gas supply component. The controller is also used to control the heating module to heat the air flowing into the cell culture incubator when the cell culture incubator is subjected to external circulation and the air outlet temperature information is less than a preset heating temperature, until the air outlet temperature information reaches the preset heating temperature, and the preset heating temperature is less than the preset temperature lower limit.

5. The regulating system for a cell culture incubator according to claim 1, characterized in that: The regulation system for the cell culture incubator also includes a humidity regulation module and a second humidity collection component, wherein the humidity regulation module is used to increase or decrease the humidity in the cell culture incubator, and the second humidity collection component is used to collect humidity information in the incubator. The controller is also used to control the humidity regulation module to increase the humidity in the cell culture incubator when the humidity information in the incubator is less than the preset humidity lower limit value until the humidity information in the incubator is greater than or equal to the preset humidity lower limit value. The controller is also used to control the humidity regulation module to decrease the humidity in the cell culture incubator when the humidity information in the incubator is greater than the preset humidity upper limit value until the humidity information in the incubator is less than or equal to the preset humidity upper limit value.

6. The regulating system for a cell culture incubator according to claim 5, characterized in that: The humidity regulating module includes a humidification module and a condensation module. The humidification module is used to increase the humidity in the cell culture box, and the condensation module is used to reduce the humidity in the cell culture box by condensing water vapor in the cell culture box.

7. The regulating system for a cell culture incubator according to claim 6, characterized in that: When the temperature information in the box is less than the preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, the process of controlling the first gas driving component to drive the outside air to flow into the cell culture box includes: When the temperature information in the box is less than a preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than a preset humidity lower limit, controlling the first gas driving component to drive external air to flow into the cell culture box; When the temperature information in the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information in the box, and the ambient humidity information is less than the preset humidity upper limit, the process of controlling the first gas driving component to drive the outside air to flow into the cell culture box includes: When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity lower limit, the first gas driving component is controlled to drive external air to flow into the cell culture box.

8. The regulating system for a cell culture incubator according to claim 1, characterized in that: The regulation system for the cell culture incubator also includes a second gas drive component, the air inlet and air outlet of the second gas drive component are both connected to the cell culture incubator, the second gas drive component is used to drive the gas circulation in the cell culture incubator, and the controller is also used to control the second gas drive component to drive the gas circulation in the cell culture incubator when the first gas drive component stops working.

9. The regulating system for a cell culture incubator according to claim 8, characterized in that: The gas outlet end of the second gas driving component is connected to the cell culture box through a flow-uniforming component.

10. A method for regulating a cell culture incubator, characterized in that: Applied in the regulating system for a cell culture incubator according to any one of claims 1 to 9, the regulating method for a cell culture incubator comprises the following steps: S1, when the temperature information in the box is less than a preset temperature lower limit, the ambient temperature information is greater than the temperature information in the box, and the ambient humidity information is less than a preset humidity upper limit, controlling the first gas driving component to drive outside air to flow into the cell culture box to perform external circulation to heat the cell culture box until the temperature information in the box is greater than or equal to the preset temperature lower limit or the difference between the ambient temperature information and the temperature information in the box is less than or equal to a first preset temperature threshold; S2. When the temperature information inside the box is greater than the preset temperature upper limit, the ambient temperature information is less than the temperature information inside the box, and the ambient humidity information is less than the preset humidity upper limit, control the first gas drive component to drive outside air to flow into the cell culture box to perform external circulation cooling on the cell culture box until the temperature information inside the box is less than or equal to the preset temperature upper limit or the difference between the temperature information inside the box and the ambient temperature information is less than or equal to a second preset temperature threshold.

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