Treatment formula acting on dizziness and preparation method thereof

Abstract

The invention discloses a treatment formula acting on dizziness and a preparation method thereof, the treatment formula comprises the following raw materials: 50-70 parts of Poria cocos, 60-80 parts of radix bupleuri, 40-50 parts of cassia twig, 10-20 parts of bighead atractylodes rhizome, 20-30 parts of gastrodia elata, 12-21 parts of dried orange peel, 12-25 parts of white peony root, 5-12 parts of licorice, 4-12 parts of dragon bone, 3-8 parts of red sage root, and 3-8 parts of pinellia ternate, and the invention relates to the technical field of medicine preparation. According to the treatment formula acting on dizziness and the preparation method thereof, the dizziness symptom can be relieved, for example, the dizziness symptom is relieved, the balance capacity is improved, the dizziness attack frequency and duration are reduced, cerebral ischemia and cerebral blood supply insufficiency are improved, neural function recovery is facilitated, the memory is enhanced, meanwhile, through cooperation of the medicinal materials, the physique of a patient can be improved, and the curative effect is good. The headache and dizziness symptoms are fundamentally treated, and the effect is good.

Description

Technical Field

[0001] The invention relates to the technical field of drug preparation, in particular to a method for preparing a therapeutic formula for dizziness. Background Art

[0002] In the medical field, dizziness and headache are common symptoms that bother many patients. Dizziness may be caused by a variety of reasons, such as ear diseases, nervous system problems, cardiovascular abnormalities, anemia, etc.; the causes of headaches are even more extensive, including tension headaches, migraines, cluster headaches, etc., as well as factors such as stress, fatigue, and bad living habits. For a long time, people have been seeking effective and safe drugs to relieve and treat these symptoms. With the continuous deepening of medical research, we have a deeper understanding of the pathological mechanisms of dizziness and headaches, which provides a solid foundation for the research and development of new dizziness and headache drugs. Researchers have worked hard to explore new drug targets and mechanisms of action through screening and improvement of natural drug ingredients, chemical synthesis of new compounds, and biotechnology. At the same time, the dosage form design of drugs is also constantly innovating to improve the absorption efficiency and bioavailability of drugs. However, the drug treatments currently available on the market often have certain limitations, the treatment effect is not obvious, there are many side effects, and they cannot regulate the human body, resulting in a situation where the symptoms are treated but not the root cause. Summary of the invention

[0003] To achieve the above purpose, the present invention is implemented by the following technical scheme: a therapeutic formula for dizziness and a preparation method thereof, which is composed of the following raw materials, including: 50-70 parts of Poria, 60-80 parts of Bupleurum, 40-50 parts of cinnamon twig, 10-20 parts of Atractylodes macrocephala, 20-30 parts of Gastrodia elata, 12-21 parts of dried tangerine peel, 12-25 parts of white peony root, 5-12 parts of liquorice, 4-12 parts of dragon bone, 3-8 parts of Salvia miltiorrhiza, and 3-8 parts of Pinellia.

[0004] Preferably, the optimal raw material composition of the therapeutic formula is 58 parts of Poria cocos, 68 parts of Bupleurum chinense, 44 parts of Cinnamon twig, 14 parts of Atractylodes macrocephala, 24 parts of Gastrodia elata, 16 parts of Citrus reticulata, 18 parts of White Peony Root, 8 parts of Licorice, 7 parts of Dragon Bone, 5 parts of Salvia miltiorrhiza, and 5 parts of Pinellia ternata.

[0005] A method for preparing a therapeutic formula for treating dizziness comprises the following steps: Step 1, weigh 50-70 parts of Poria cocos, 60-80 parts of Bupleurum chinense, 40-50 parts of Cinnamon twig, 20-30 parts of Gastrodia elata, 12-21 parts of Tangerine peel, and 12-25 parts of White Peony Root, and soak them in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying; Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 10-20 parts of Atractylodes macrocephala, 5-12 parts of Licorice root, and 4-12 parts of Dragon bone, clean them, and cut them into sections to obtain segmented medicinal materials; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours, collect the cooking extract and filter to obtain a filtrate, apply the filtrate to a D101 macroporous adsorption resin column, and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradient elute in sequence, and collect the 50% ethanol eluate; Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1-1.5 hours, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 3-8 parts of Salvia miltiorrhiza, distill it with 3 times the mass of water for 9-12 hours, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 3-8 portions of Pinellia ternata, add 30%-80% ethanol to the medicinal material and heat to reflux, repeat reflux extraction 1-3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15-1.35, 80-95% by volume of ethanol is added to the clear paste to make the alcohol content reach 20-50% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15-1.45; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. After drying, crush it and pass it through a 60-mesh sieve to obtain a powder.

[0006] Preferably, the soaking time in step 1 is 3-5 hours, and during the soaking process, the medicinal materials are squeezed through a filter screen so that the medicinal materials are completely immersed in water.

[0007] Preferably, the moisture content of the dried medicinal material in step 2 is 8%-12%, and the length of the cut medicinal material is maintained at 1-1.5 cm.

[0008] Preferably, the length of the medicinal material after cutting in step 4 is maintained at 0.5-1.2 cm.

[0009] Preferably, in step 5, the column flow rate is 1.3-1.5 BV / h, and the elution flow rate is 1.3-1.5 BV / h.

[0010] Preferably, the heating reflux temperature in step eight is 70-80 degrees Celsius.

[0011] Preferably, the relative densities in step nine and step ten are both measured at a temperature of 80 degrees Celsius.

[0012] Preferably, in the step eleven, the vacuum drying temperature is 45-55° C., the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%-8%.

[0013] The present invention provides a therapeutic formula for dizziness and a preparation method thereof. It has the following beneficial effects: The therapeutic formula for dizziness and the preparation method thereof can relieve dizziness symptoms, such as reducing vertigo, improving balance, reducing the frequency and duration of dizziness attacks, improving cerebral ischemia and cerebral blood supply insufficiency, being beneficial to the recovery of nerve function, and enhancing memory. At the same time, the coordination between medicinal materials can also improve the patient's physical condition, and fundamentally treat the symptoms of headache and dizziness with good results. DETAILED DESCRIPTION

[0014] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0015] In the first embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 50-70 parts of Poria cocos, 60-80 parts of Bupleurum chinense, 40-50 parts of Cinnamon twig, 20-30 parts of Gastrodia elata, 12-21 parts of Tangerine peel, and 12-25 parts of White Peony Root, soak them in water for 3-5 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 8%-12%, and the length of the cut medicinal materials is kept at 1-1.5 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 10-20 parts of Atractylodes macrocephala, 5-12 parts of Licorice root, and 4-12 parts of Dragon bone, clean them and cut them into segments to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 0.5-1.2 cm; Step 5: Put the segmented medicinal material in step 4 together with 5 times the weight of water into a cooking device and cook for 2-3 hours, collect the cooking extract and filter to obtain a filtrate, apply the filtrate to a D101 macroporous adsorption resin column, and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence, collect the 50% ethanol eluate, the column flow rate is 1.3-1.5BV / h, and the elution flow rate is 1.3-1.5BV / h; Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1-1.5 hours, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 3-8 parts of Salvia miltiorrhiza, distill it with 3 times the mass of water for 9-12 hours, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 3-8 portions of Pinellia ternata, add 30%-80% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 70-80 degrees Celsius, repeat the reflux extraction 1-3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15-1.35, 80-95% by volume of ethanol is added to the clear paste to make the alcohol content reach 20-50% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15-1.45; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 45-55°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%-8%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0016] In the second embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 53 parts of Poria cocos, 63 parts of Bupleurum chinense, 42 parts of Cinnamon twig, 22 parts of Gastrodia elata, 15 parts of Tangerine peel, and 14 parts of White Peony Root, soak them in water for 3 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 8%, and the length of the cut medicinal materials is kept at 1 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 12 parts of Atractylodes macrocephala, 7 parts of Licorice root, and 6 parts of Dragon bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 0.5 cm; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours. Collect the cooking extract and filter to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.3BV / h and the elution flow rate is 1.3BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1 hour, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 4 parts of Danshen, distill 9 with 3 times the mass of water, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 4 portions of Pinellia ternata, add 30% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 70 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15, 80% by volume of ethanol is added to the clear paste to make the alcohol content reach 20% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 45°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0017] In a third embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 55 parts of Poria cocos, 65 parts of Bupleurum chinense, 44 parts of Cinnamon twig, 24 parts of Gastrodia elata, 17 parts of Tangerine peel, and 18 parts of White Peony Root, soak them in water for 3 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 8%, and the length of the cut medicinal materials is kept at 1 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 14 parts of Atractylodes macrocephala, 9 parts of Licorice root, and 8 parts of Dragon bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 0.5 cm; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours. Collect the cooking extract and filter to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.3BV / h and the elution flow rate is 1.3BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1 hour, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 5 parts of Salvia miltiorrhiza, distill 9 parts with 3 times the mass of water, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 5 parts of Pinellia ternata, add 30% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 70 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter several times, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15, 80% by volume of ethanol is added to the clear paste to make the alcohol content reach 20% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 45°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0018] In a fourth embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 57 parts of Poria cocos, 67 parts of Bupleurum chinense, 46 parts of Cinnamon twig, 26 parts of Gastrodia elata, 19 parts of Tangerine peel, and 20 parts of White Peony Root, soak them in water for 3 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 8%, and the length of the cut medicinal materials is kept at 1 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 16 parts of Atractylodes macrocephala, 10 parts of Licorice root, and 9 parts of Dragon bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 0.5 cm; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours. Collect the cooking extract and filter to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.3BV / h and the elution flow rate is 1.3BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1 hour, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 6 parts of Salvia miltiorrhiza, distill 9 parts with 3 times the mass of water, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 6 portions of Pinellia ternata, add 30% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 70 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15, 80% by volume of ethanol is added to the clear paste to make the alcohol content reach 20% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 45°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0019] In a fifth embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 58 parts of Poria cocos, 58 parts of Bupleurum chinense, 44 parts of Cinnamon twig, 14 parts of Gastrodia elata, 16 parts of Tangerine peel, and 18 parts of White Peony Root, soak them in water for 3 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 8%, and the length of the cut medicinal materials is kept at 1 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 14 parts of Atractylodes macrocephala, 8 parts of Licorice, and 7 parts of Dragon Bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 0.5 cm; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours. Collect the cooking extract and filter to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.3BV / h and the elution flow rate is 1.3BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1 hour, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 5 parts of Salvia miltiorrhiza, distill 9 parts with 3 times the mass of water, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 5 parts of Pinellia ternata, add 30% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 70 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter several times, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15, 80% by volume of ethanol is added to the clear paste to make the alcohol content reach 20% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 45°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0020] In a sixth embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 58 parts of Poria cocos, 68 parts of Bupleurum chinense, 44 parts of Cinnamon twig, 24 parts of Gastrodia elata, 16 parts of Tangerine peel, and 18 parts of White Peony Root, soak them in water for 5 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 12%, and the length of the cut medicinal materials is kept at 1.5 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 14 parts of Atractylodes macrocephala, 8 parts of Licorice, and 7 parts of Dragon Bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 1.2 cm; Step 5: Put the segmented medicinal material in step 4 together with 5 times the weight of water into a cooking device and cook for 3 hours. Collect the cooking extract and filter it to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.5BV / h and the elution flow rate is 1.5BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1.5 hours, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 5 parts of Danshen, distill it with 3 times the mass of water for 12 hours, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 5 parts of Pinellia ternata, add 80% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 80 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.35, 95% by volume of ethanol is added to the clear paste to make the alcohol content reach 50% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.45; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 55°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 8%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0021] In the seventh embodiment, the present invention provides a technical solution: a method for preparing a therapeutic formula for dizziness, comprising the following steps: Step 1, weigh 65 parts of Poria cocos, 75 parts of Bupleurum chinense, 48 parts of Cinnamon twig, 28 parts of Gastrodia elata, 20 parts of Tangerine peel, and 24 parts of White Peony Root, soak them in water for 5 hours, and squeeze the medicinal materials through a filter during the soaking process so that the medicinal materials are completely submerged in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying. The moisture content of the dried medicinal materials is 12%, and the length of the cut medicinal materials is kept at 1.5 cm. Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 18 parts of Atractylodes macrocephala, 11 parts of Licorice root, and 11 parts of Dragon bone, clean them and cut them into sections to obtain segments of medicinal materials. The length of the cut medicinal materials is kept at 1.2 cm; Step 5: Put the segmented medicinal material in step 4 together with 5 times the weight of water into a cooking device and cook for 3 hours. Collect the cooking extract and filter it to obtain a filtrate. Apply the filtrate to a D101 macroporous adsorption resin column and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradiently elute in sequence. Collect the 50% ethanol eluate. The column flow rate is 1.5BV / h and the elution flow rate is 1.5BV / h. Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1.5 hours, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 7 parts of Salvia miltiorrhiza, distill it with 3 times the mass of water for 12 hours, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 7 parts of Pinellia ternata, add 80% ethanol to the medicinal material and heat to reflux, the heating reflux temperature is 80 degrees Celsius, repeat the reflux extraction 3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.35, 95% by volume of ethanol is added to the clear paste to make the alcohol content reach 50% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.45; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. The vacuum drying temperature is 55°C, the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 8%. After drying, the paste is crushed and passed through a 60-mesh sieve to obtain a powder.

[0022] According to the comparison of the drugs prepared in the above embodiments, it is found that the drug prepared in the fifth embodiment has the best effect.

[0023] Therefore, the optimal raw material ratio of the medicine in this case is: 58 parts of Poria cocos, 68 parts of Bupleurum chinense, 44 parts of cinnamon twig, 14 parts of Atractylodes macrocephala, 24 parts of Gastrodia elata, 16 parts of dried tangerine peel, 18 parts of white peony root, 8 parts of licorice, 7 parts of dragon bone, 5 parts of Salvia miltiorrhiza, and 5 parts of Pinellia ternata.

[0024] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field and related fields without creative work should fall within the scope of protection of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention are implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A therapeutic formula for dizziness, characterized in that: It is composed of the following raw materials: 50-70 parts of Poria, 60-80 parts of Bupleurum, 40-50 parts of cinnamon twig, 10-20 parts of Atractylodes macrocephala, 20-30 parts of Gastrodia elata, 12-21 parts of dried tangerine peel, 12-25 parts of white peony root, 5-12 parts of liquorice, 4-12 parts of dragon bone, 3-8 parts of Salvia miltiorrhiza, and 3-8 parts of Pinellia.

2. A therapeutic formula for treating dizziness according to claim 1, characterized in that: The optimal raw material composition of the therapeutic formula is 58 parts of Poria cocos, 68 parts of Bupleurum chinense, 44 parts of Cinnamon twig, 14 parts of Atractylodes macrocephala, 24 parts of Gastrodia elata, 16 parts of Tangerine peel, 18 parts of White Peony Root, 8 parts of Licorice, 7 parts of Dragon Bone, 5 parts of Salvia miltiorrhiza, and 5 parts of Pinellia ternata.

3. The method for preparing a therapeutic formula for dizziness according to claim 1, characterized in that: The following steps are involved: Step 1, weigh 50-70 parts of Poria cocos, 60-80 parts of Bupleurum chinense, 40-50 parts of Cinnamon twig, 20-30 parts of Gastrodia elata, 12-21 parts of Tangerine peel, and 12-25 parts of White Peony Root, and soak them in water; Step 2: Take out the soaked medicinal materials in step 1, cut them into sections and put them into the drying equipment for drying; Step 3: Put the dried medicinal materials in step 2 into the grinding equipment for grinding, and pass the ground medicinal material powder through a 15-mesh sieve to obtain medicinal material powder for standby use; Step 4: Weigh 10-20 parts of Atractylodes macrocephala, 5-12 parts of Licorice root, and 4-12 parts of Dragon bone, clean them, and cut them into sections to obtain segmented medicinal materials; Step 5: Put the segmented medicinal material in step 4 and 5 times the weight of water into a cooking device and cook for 2-3 hours, collect the cooking extract and filter to obtain a filtrate, apply the filtrate to a D101 macroporous adsorption resin column, and use 4BV of water, 2BV of 50% ethanol, and 1BV of 95% ethanol to gradient elute in sequence, and collect the 50% ethanol eluate; Step 6: Evenly mix the medicinal material powder in step 3 and the eluent in step 5, and then put them into a cooking device for cooking for 1-1.5 hours, collect the cooking extract and filter to obtain a filtrate; Step 7, weigh 3-8 parts of Salvia miltiorrhiza, distill it with 3 times the mass of water for 9-12 hours, collect the distillate, add 1.5 mol / L hydrochloric acid to the distillate, let it stand for 15 minutes, and then filter to obtain a filtrate; Step 8, weigh 3-8 portions of Pinellia ternata, add 30%-80% ethanol to the medicinal material and heat to reflux, repeat reflux extraction 1-3 times, the amount of ethanol added is 5 times the amount of the medicinal material, the extraction time is 3 hours, filter in batches, and combine the filtrate; Step 9, the filtrates in step 6, step 7 and step 8 are mixed evenly to obtain a final filtrate, the final filtrate is concentrated to a clear paste with a relative density of 1.15-1.35, 80-95% by volume of ethanol is added to the clear paste to make the alcohol content reach 20-50% by volume; and the mixture is allowed to stand for 10 hours; Step 10, taking the supernatant to recover ethanol until it is exhausted, and concentrating it into a thick paste with a relative density of 1.15-1.45; Step 11: Place the thick paste in step 10 into a vacuum drying device for drying. After drying, crush it and pass it through a 60-mesh sieve to obtain a powder.

4. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The soaking time in step 1 is 3-5 hours. During the soaking process, the medicinal materials are squeezed through the filter screen so that the medicinal materials are completely immersed in the water.

5. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The moisture content of the dried medicinal material in step 2 is 8%-12%, and the length of the cut medicinal material is maintained at 1-1.5 cm.

6. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The length of the medicinal material after being cut in step 4 is maintained at 0.5-1.2 cm.

7. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: In the step 5, the column flow rate is 1.3-1.5 BV / h, and the elution flow rate is 1.3-1.5 BV / h.

8. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The temperature of heating reflux in step eight is 70-80 degrees Celsius.

9. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The relative densities in step nine and step ten are both measured at a temperature of 80 degrees Celsius.

10. The method for preparing a therapeutic formula for dizziness according to claim 3, characterized in that: The vacuum drying temperature in the step 11 is 45-55° C., the vacuum drying time is 15 hours, and the moisture content after vacuum drying is 3%-8%.