Traditional Chinese medicine composition and medicament for dispelling effects of alcohol, stopping vomiting, nourishing liver and protecting stomach and preparation method of traditional Chinese medicine composition and medicament

Abstract

The invention relates to the field of traditional Chinese medicine anti-alcoholism compositions, and discloses a traditional Chinese medicine composition for relieving alcoholism, stopping vomiting and nourishing liver and protecting stomach, a medicament and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 4-8 parts of radix puerariae, 2-5 parts of hovenia dulcis thunb, 2-4 parts of pericarpium citri reticulatae, 2-5 parts of mulberry, 2-4 parts of liquorice, 2-3 parts of emblic leafflower fruit, 1-3 parts of flos puerariae and 1-2 parts of inula flower. Compared with the prior art, the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition of the radix puerariae, the semen hoveniae, the pericarpium citri reticulatae, the mulberries, the licorice roots, the emblic leafflower fruits, the pueraria flowers and the inula flowers is proportionally combined, the synergistic effect is achieved, the effects of dispelling the effects of alcohol and nourishing the liver are remarkable, the effects of dispelling the effects of alcohol and nourishing the liver are achieved, vomiting can be further stopped, the stomach can be further nourished, and the adverse reaction after drinking is greatly relieved.

Description

Technical Field

[0001] The invention relates to a Chinese medicinal composition for sobering up, and in particular to a Chinese medicinal composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach, a medicament and a preparation method thereof. Background Art

[0002] The liver is the largest solid organ in the abdominal cavity and is responsible for important physiological functions of the human body. Liver cells have poor tolerance to hypoxia, so the hepatic artery and portal vein provide abundant blood supply, and large and small bile ducts and blood vessels transport bile. Currently, bad living habits such as staying up late, alcoholism, and irritability can easily cause liver damage and affect the liver's detoxification ability. Among them, alcohol-induced liver damage is the most common.

[0003] According to traditional Chinese medicine, alcohol is of a damp-heat nature. Damp-heat toxic evil invades the spleen and stomach in the middle burner, causing the spleen to lose its function and damp-heat to stagnate inside the body, resulting in abdominal distension and fullness. Heat evil burns body fluids, causing dry mouth and throat. Damp-heat blocks the middle burnt qi, causing the stomach to lose its harmony and descend, and stomach qi to rise, resulting in nausea and vomiting. Damp-heat burns the liver and kidneys, causing liver and kidney yin damage, dizziness, fatigue and shortness of breath. Internal accumulation of damp-heat results in red urine, yellow and greasy tongue coating, and a weak and rapid pulse.

[0004] The existing alcohol-relieving and liver-nourishing drugs mainly function to relieve alcohol and nourish the liver, but people still suffer from adverse reactions such as vomiting after being drunk, which are difficult to resolve. Summary of the invention

[0005] In order to solve the problems raised in the above background technology, the purpose of the present invention is to provide a Chinese medicine composition and medicament for sobering up, stopping vomiting, nourishing the liver and protecting the stomach.

[0006] To solve the above technical problems, the technical solution provided by the present invention is: a traditional Chinese medicine composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach, wherein the traditional Chinese medicine composition is made of the following raw materials in proportions by weight: 4-8 parts of Pueraria root, 2-5 parts of Hovenia dulcis, 2-4 parts of dried tangerine peel, 2-5 parts of mulberry, 2-4 parts of liquorice, 2-3 parts of emblica fruit, 1-3 parts of Pueraria flower, and 1-2 parts of Inula flower.

[0007] As an improvement, 8 parts of Pueraria root, 5 parts of Hovenia dulcis, 4 parts of dried orange peel, 4 parts of mulberry, 4 parts of liquorice, 3 parts of emblica, 2 parts of Pueraria flower and 1 part of Inula flower are used to obtain a traditional Chinese medicine composition.

[0008] As an improvement, the Chinese medicine preparation is composed of the above-mentioned Chinese medicine composition and a liquid beverage.

[0009] As an improvement, the liquid of the Chinese medicine composition is steamed and boiled according to a weight ratio to make it into a dry powder, and then mixed with concentrated fruit juice or purified water.

[0010] The beneficial effect of the present invention is that the present invention exerts a synergistic effect through the combination of the proportions of the Chinese medicine composition of kudzu root, durian fruit, tangerine peel, mulberry, liquorice, emblica fruit, kudzu flower and inula flower, and can sober up and nourish the liver with significant therapeutic effects. The present invention not only has the effects of sobering up and nourishing the liver, but can further stop vomiting and nourish the stomach, thereby greatly reducing adverse reactions after drinking.

[0011] Pueraria root is sweet, spicy and cool in nature, and enters the spleen and stomach meridians. It has the effects of relieving muscle and fever, promoting body fluid and quenching thirst, and detoxifying alcohol. The isoflavone compounds in Pueraria root can accelerate the metabolism of alcohol in the body, reduce the toxic effects of alcohol on the liver, and protect liver cells from damage.

[0012] Hovenia dulcis is sweet in taste, neutral in nature, and belongs to the stomach meridian. It has the effects of promoting diuresis and reducing swelling, detoxifying alcohol, and stopping vomiting. It can promote urine excretion, help the body excrete excess alcohol and its metabolites, thereby reducing the harm of alcohol to the body.

[0013] Tangerine peel is bitter, pungent, and warm in nature, and enters the lung and spleen meridians. Its main effects are regulating qi and strengthening the spleen, and drying dampness and resolving phlegm. In the prescription for alcohol detoxification and liver protection, tangerine peel can harmonize the spleen and stomach, and relieve discomfort such as nausea and vomiting caused by drinking. Mulberries are sweet, sour, and cold in nature, and enter the heart, liver, and kidney meridians. They have the effects of nourishing yin and blood, promoting body fluid and moistening dryness. Although its main function is not to directly detoxify alcohol, it can nourish the liver and kidneys and indirectly help the body recover health.

[0014] Phyllanthus emblica is sweet, sour, astringent and cool in nature, and belongs to the lung and stomach meridians. It has the effects of clearing heat and cooling blood, promoting digestion and strengthening the stomach, promoting body fluid and relieving cough. It can relieve symptoms such as dry mouth and stomach discomfort caused by drinking.

[0015] Kudzu flower is sweet and flat in nature, and has the effects of sobering up, invigorating the spleen, nourishing the stomach and stopping vomiting. Similar to kudzu root, kudzu flower can also promote the metabolism and excretion of alcohol, and reduce the damage of alcohol to the liver.

[0016] The nature of Inula flower is bitter, pungent, salty and slightly warm. It enters the lung, spleen, stomach and large intestine meridians. It has the effects of lowering qi, eliminating phlegm, promoting water circulation and stopping vomiting. In the prescription for alcohol detoxification and liver protection, Inula flower can relieve vomiting caused by drinking.

[0017] Licorice is sweet and mild in nature, and enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, and harmonizing various medicines. In the alcohol-relieving and liver-protecting prescription, licorice can harmonize various herbs, enhance the overall therapeutic effect, and at the same time reduce the stimulation of alcohol to the body. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a comparison chart of experimental results of a traditional Chinese medicine composition and medicament for sobering up, stopping vomiting, nourishing the liver and protecting the stomach and a preparation method thereof according to the present invention. DETAILED DESCRIPTION

[0019] The present invention is described below with specific embodiments, but is not intended to be limiting of the present invention.

[0020] Embodiment 1

[0021] A traditional Chinese medicine composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach is prepared from the following raw materials in proportion by weight: 4-8 parts of kudzu root, 2 parts of Hovenia dulcis, 2 parts of dried orange peel, 2 parts of mulberry, 2 parts of liquorice, 2 parts of emblica fruit, 1 part of kudzu flower, and 1 part of inula flower. The liquid of the traditional Chinese medicine composition is steamed and made into dry powder according to the proportion by weight, and then the powder is mixed with concentrated juice or purified water.

[0022] Embodiment 2

[0023] A traditional Chinese medicine composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach is prepared from the following raw materials in proportion by weight: 6 parts of kudzu root, 3 parts of Hovenia dulcis, 3 parts of dried orange peel, 3 parts of mulberry, 3 parts of liquorice, 3 parts of emblica fruit, 2 parts of kudzu flower, and 2 parts of inula flower. The liquid of the traditional Chinese medicine composition is steamed and made into dry powder according to the proportion by weight, and then the powder is mixed with concentrated juice or purified water.

[0024] Embodiment 3

[0025] A traditional Chinese medicine composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach is prepared from the following raw materials in proportion by weight: 8 parts of kudzu root, 5 parts of Hovenia dulcis, 4 parts of dried orange peel, 5 parts of mulberry, 4 parts of liquorice, 3 parts of emblica fruit, 3 parts of kudzu flower and 2 parts of inula flower. The liquid of the traditional Chinese medicine composition is steamed and boiled according to the proportion by weight to make it into dry powder, and then the powder is mixed with concentrated juice or purified water.

[0026] Animal experiments

[0027] 2. Pharmacodynamics Test

[0028] 1. Test materials: the samples of Examples 1-3 prepared above; alcohol, liquid alcohol feed (containing 5% alcohol) was selected.

[0029] 2. Animals: 50 healthy male mice, 6-8 weeks old, weighing 30±2g, fed with normal feed, with free access to water and food.

[0030] 3. Animal grouping: The mice were randomly divided into 5 groups (10 mice in each group), namely, blank control group, model control group, Example 1 group, Example 2 group, and Example 3 group.

[0031] The blank group was fed with saline; the model group was fed with liquid alcohol feed (1.45 g / kg); the Example 1-3 groups were first fed with the Example 1-3 samples (6 g / kg), and then fed with liquid alcohol feed (1.45 g / kg) 1 hour later.

[0032] 4. Detection method: After 4 weeks of feeding, blood is collected from the eyeballs, and the serum is separated and stored at low temperature for testing.

[0033] 5. Test results:

[0034] (1) General observation: The blank control group had shiny hair, lively body, good sensitivity, normal appetite and stool, and a weight increase of 5g; the Example 1-3 groups had shiny hair, lively body, good sensitivity, normal appetite and stool, and a weight increase of 3g; the model control group had poor hair gloss, sluggish body, poor sensitivity, small appetite, loose stool, and a weight increase of 1g.

[0035] (2) Comparison of serum ALT, AST, and GGT: see Figure 1 The serum ALT, AST and GGT in the model control group and the embodiment group were significantly higher than those in the blank control group (P﹤0.01); compared with the model control group, the embodiment group could significantly reduce the serum ALT, AST and GGT levels (P﹤0.01).

[0036] (3) ALT, AST, and GGT are enzymes released after liver cells are destroyed. This test can reflect the inflammation or necrotic lesions of the liver system by measuring the representative enzymes ALT, AST, and GGT in mouse serum. Through the above test, the results show that the present invention can effectively reduce ALT, AST, and GGT in mouse serum; indicating that the present invention can improve the tissue hypoxia environment, reduce the generation of oxidative free radicals and lipid peroxidation reactions in the body, enhance the body's anti-endotoxin and antioxidant capabilities, improve cell membrane stability, protect liver cells, and have a protective effect on alcoholic liver damage without causing toxic reactions.

[0037] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese medicine composition for sobering up, stopping vomiting, nourishing the liver and protecting the stomach, characterized in that: The Chinese medicine composition is prepared from the following raw materials in proportions by weight: 4-8 parts of kudzu root, 2-5 parts of durian fruit, 2-4 parts of tangerine peel, 2-5 parts of mulberry, 2-4 parts of liquorice, 2-3 parts of emblica fruit, 1-3 parts of kudzu flower, and 1-2 parts of inula flower.

2. A Chinese medicine composition for sobering up, relieving vomiting, nourishing the liver and protecting the stomach according to claim 1, characterized in that: The Chinese medicine composition is obtained by taking 8 parts of Pueraria root, 5 parts of Hovenia dulcis, 4 parts of dried orange peel, 4 parts of mulberry, 4 parts of liquorice, 3 parts of emblica fruit, 2 parts of Pueraria flower and 1 part of Inula flower.

3. A Chinese medicinal preparation for sobering up, stopping vomiting, nourishing the liver and protecting the stomach according to claim 2, characterized in that: The traditional Chinese medicine preparation is composed of the above-mentioned traditional Chinese medicine composition and a liquid beverage.

4. The method for preparing a traditional Chinese medicine for sobering up, stopping vomiting, nourishing the liver and protecting the stomach according to claim 3, characterized in that: The liquid of the Chinese medicinal composition is steamed and boiled according to a weight ratio to make it into a dry powder, and then the powder is mixed with concentrated fruit juice or purified water.

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