Preparation process of spray composite disinfectant

Abstract

The invention relates to the technical field of disinfection, and particularly discloses a preparation process of a spray composite disinfectant, the composite disinfectant is prepared from the following raw materials: a disinfectant, a wetting agent, a synergist, a moisturizing aid, a solvent and water, and the preparation process comprises the following specific preparation steps: adding the disinfectant and the wetting agent into the solvent, uniformly dispersing, then adding the synergist, the moisturizing aid and the water, uniformly dispersing, adding the wetting agent, the synergist and the moisturizing aid, and uniformly dispersing to obtain the spray composite disinfectant. The wetting agent is poly (alpha alkenyl sulfonate). The spray composite disinfectant provided by the invention is good in formula dispersity, stable in storage and free of layering, is suitable for automatic spray disinfection and artificial spray disinfection, has excellent disinfection and sterilization effects, and does not cause the problem of sharp increase of the content of microorganisms in air within a short disinfection time.

Description

Technical Field

[0001] The present application relates to the field of disinfection technology, and more specifically, to a preparation process of a spray composite disinfectant. Background Art

[0002] With the intensive and large-scale development of livestock and poultry farming, the management of livestock and poultry farming environment has become increasingly important. Among them, disinfection is a key measure to prevent and control livestock and poultry infectious diseases, and its importance is self-evident. Spray disinfection, as a disinfection method, has been widely used in livestock and poultry farming because of its high efficiency, convenience, and ability to quickly reduce the content of pathogenic microorganisms.

[0003] Spray disinfection sprays disinfectants in the form of mist, so that the disinfectants can fully contact every corner of the poultry house, including the air, ground, walls, cages and the surface of livestock and poultry, thereby effectively killing pathogenic microorganisms, reducing their content, and reducing the chance of livestock and poultry contacting pathogens, thereby controlling the spread of diseases. In addition, some acidic disinfectants can also neutralize ammonia in the poultry house, reduce the dust content in the air, and reduce irritation to livestock and poultry. In the hot summer, spray disinfection can also promote evaporative heat dissipation and play a cooling role.

[0004] Spray disinfection is a widely used disinfection method, which is favored because of its simple operation, wide coverage and high disinfection efficiency. However, in actual application, the use of livestock and poultry spray disinfectants also faces a series of challenges, especially the technical problem of "spraying easily leads to a surge in the content of microorganisms in the air", which has become a key point to be solved urgently.

[0005] Traditional livestock and poultry spray disinfectants are mostly chemical preparations, such as sodium hypochlorite, peracetic acid, quaternary ammonium salts, etc. While these disinfectants kill pathogenic microorganisms, they may also cause the content of microorganisms (including bacteria, viruses, fungi, etc.) in the air to rise rapidly in a short period of time due to the droplets and aerosols generated during the spraying process. In addition, some disinfection methods have limitations, such as manual spray disinfection. The water mist droplets sprayed from the nozzle are generally large in particle size and have poor atomization effect. The water mist sprayed from the nozzle hammers the ground, walls, equipment, etc., causing dust and dust to rise, resulting in an increase in the content of air microorganisms after disinfection, even higher than before disinfection. The occurrence of this phenomenon may not only weaken the disinfection effect, but also irritate the respiratory system of livestock and poultry, increase the risk of livestock and poultry diseases, and even pose a threat to the health of human operators.

[0006] In response to this problem, the industry has begun to explore the preparation process and disinfection methods of livestock and poultry spray composite disinfectants that can reduce the content of microorganisms in the air. The research focuses on developing new disinfectant ingredients, optimizing disinfectant formulas, improving spraying devices, and improving spraying technology. For example, in the preparation process, microencapsulation, nano-materialization and other technologies are used to improve the stability and dispersibility of disinfectants, so that they can cover the target area more evenly during the spraying process and reduce the generation of droplets and aerosols; in the disinfection process, the development of intelligent spraying systems, by accurately controlling the spraying time, frequency and amount, and optimizing the spraying path, the precise application of disinfectants is achieved, which is also an effective way to solve the problem of the surge in microbial content in the air.

[0007] Whether it is microencapsulation, nano-materialization, or the development of intelligent spraying systems, the formulation of spray compound disinfectants will be complicated and the cost of disinfection equipment will increase. The technical problem of the surge in microbial content in the air when spraying livestock and poultry spray disinfectants still needs to be solved in a simple, effective and reliable way. Summary of the invention

[0008] In order to solve the above-mentioned technical problems, the present application provides a preparation process of a spray composite disinfectant, which has good formula dispersibility, stable storage and no stratification, is suitable for automatic spray disinfection and manual spray disinfection, has excellent disinfection and sterilization effects, and will not cause a surge in the content of microorganisms in the air within a short period of time.

[0009] The present application provides a preparation process of a spray composite disinfectant, which adopts the following technical scheme: A preparation process of a spray composite disinfectant. The raw materials for preparing the composite disinfectant include a disinfectant, a wetting agent, a synergist, a moisturizing aid, a solvent, and water. The specific preparation steps are: adding the disinfectant and the wetting agent into the solvent, dispersing them evenly, then adding the synergist, the moisturizing aid, and water, and dispersing them evenly to obtain the composite disinfectant.

[0010] Wherein, the wetting agent is poly-α-olefin sulfonate, preferably sodium poly-α-olefin sulfonate.

[0011] When a disinfectant with weak wetting ability is sprayed into dust, it is easy to form encapsulated beads, and the dust that is not wetted by the disinfectant is easy to rise, resulting in an increase in the content of microorganisms in the air in a short period of time. The poly-alpha-olefin sodium sulfonate provided in this application has a test contact angle of 32.30° on the surface of the coal block. It has a very strong wetting ability and high surface activity, and can well reduce the interfacial energy, so that the atomized disinfectant can instantly wet the surface of the dust after contacting the ground, walls and equipment, making it less likely to rise; and the poly-alpha-olefin sodium sulfonate has excellent dispersibility and hard water resistance, good compatibility with various raw material components such as disinfectants, and the prepared composite disinfectant is stable and non-stratified during storage.

[0012] Preferably, the raw materials of the composite disinfectant include, by mass percentage, 5-10% disinfectant, 10-15% wetting agent, 5-10% synergist, 5-10% moisturizing aid, 5-10% solvent, and the remainder water.

[0013] Preferably, in terms of mass percentage, the raw materials of the composite disinfectant include: 10% disinfectant, 12% wetting agent, 8% synergist, 8% moisturizing aid, 8% solvent, and 54% water.

[0014] Preferably, the carbon chain length of the poly-α-olefin sulfonate is C 12 -C 20 More preferably, the carbon chain length of the poly-α-olefin sulfonate is C 12 -C 20 The structure of poly-α-olefin sulfonate contains CS connection, which is chemically stable. At the same time, the molecular chain contains -SO 3 H, -OH and other hydrophilic groups, and have certain surface activity and reactivity.

[0015] Furthermore, the preparation method of the sodium poly-α-olefin sulfonate is as follows: sodium α-olefin sulfonate, a chain transfer agent and deionized water are mixed, an initiator is added under heating and stirring conditions, the temperature is increased for the first time and kept warm for a period of time, and then the temperature is increased for the second time and kept warm for a period of time, cooling after the reaction is completed, adjusting the pH to neutral, performing reduced pressure distillation, removing deionized water, and obtaining the sodium poly-α-olefin sulfonate.

[0016] Preferably, based on sodium α-olefin sulfonate, the mass fraction of the chain transfer agent is 0.5-1%, preferably 0.7%.

[0017] Preferably, based on sodium α-olefin sulfonate, the mass fraction of the initiator is 1-5%, preferably 4%.

[0018] Preferably, the chain transfer agent is at least one of phosphite, hypophosphite, dodecyl mercaptan, organic tin compound, mercaptopropionic acid, and sodium methyl propylene sulfonate. Specifically, the chain transfer agent is sodium hypophosphite.

[0019] Preferably, the initiator is at least one of peroxide, azo, n-butyl lithium and Lewis acid. Specifically, the initiator is benzoyl peroxide.

[0020] Preferably, the heating temperature after mixing the sodium α-olefin sulfonate, the chain transfer agent and the deionized water is 65-75°C, preferably 70°C.

[0021] Preferably, the temperature after the first heating is 70-80°C, preferably 75°C; the insulation time is 1-3h, preferably 2h.

[0022] Preferably, the temperature after the second heating is 75-85°C, preferably 80°C; the insulation time is 1-3h, preferably 1.5h.

[0023] Preferably, the CMC of the sodium α-olefin sulfonate monomer is 3.1×10 -2 mol / L, the CMC of the poly-α-olefin sulfonate sodium is 6.2×10 -2 mol / L.

[0024] Preferably, the disinfectant is at least one of quaternary ammonium salt compounds, slightly acidic electrolyzed water, peroxide compounds, and biguanide compounds. More preferably, the disinfectant is quaternary ammonium salt compounds or slightly acidic electrolyzed water.

[0025] Further, the quaternary ammonium salt compound adopts a double-chain quaternary ammonium salt compound, and the double-chain quaternary ammonium salt compound includes but is not limited to at least one of dioctyl quaternary ammonium salt, didecyl quaternary ammonium salt, didodecyl quaternary ammonium salt or octyldecyl quaternary ammonium salt, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, dioctadecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium bromide, and dioctadecyl dimethyl ammonium bromide.

[0026] Furthermore, the slightly acidic electrolyzed water is obtained by electrolysis of 2-6% dilute hydrochloric acid, has a pH of 5.0-6.5, and an effective chlorine concentration of 10-30 ppm.

[0027] Preferably, the synergist is one or a mixture of two or more of propylene glycol, pentylene glycol, decyl glycol and p-hydroxyacetophenone.

[0028] Preferably, the moisturizing aid is at least one of sorbitol, xylitol, urea, 1,2-propylene glycol, polypropylene glycol, and glycerol.

[0029] Preferably, the solvent is at least one of water, ethanol, ethylene glycol, propylene glycol, and glacial acetic acid, wherein the water may be tap water, spring water, underground well water, drinking purified water, deionized water, etc., preferably drinking purified water and deionized water.

[0030] Furthermore, in certain embodiments, the composite disinfectant may also contain common flavors, cosolvents, etc. in the market. The flavor may be artificially synthesized or natural plant extracts, etc., and the cosolvent may be hydrogenated castor oil or flavor cosolvents, etc.

[0031] Preferably, the pH value of the composite disinfectant provided by the present application is 4-10.

[0032] Preferably, the composite disinfectant provided in the present application can be used directly or after being diluted with water, and the dilution ratio V / V when diluted with water is 1:(50-100).

[0033] In summary, the beneficial effects of the present application are as follows: the present application adopts the addition of sodium poly-α-olefin sulfonate as a wetting agent, which not only disperses the raw material components well, but also makes the prepared composite disinfectant stable and not stratified, and has good sterilization and disinfection effects, especially for air microorganisms in livestock and poultry houses. The sterilization rate is high, and the problem of a surge in the content of microorganisms in the air within a short period of time after disinfection will not occur; in addition, the present application has a simple formula, does not require encapsulation or nano-ization, and is suitable for automatic spray disinfection as well as manual spray disinfection. DETAILED DESCRIPTION

[0034] The present application is further described in detail below with reference to the embodiments.

[0035] Preparation Example: Preparation of poly-α-olefin sodium sulfonate: 200 g of sodium α-olefin sulfonate monomer (purchased from Shenyang Yilepux Chemical Co., Ltd., C 14 -C 16 ), 1.4g sodium hypophosphite chain transfer agent and 200mL deionized water were mixed, heated to 70°C and 8g toluyl peroxide initiator was added under stirring, the temperature was raised to 75°C and kept warm for 2h, then raised to 80°C and kept warm for 1.5h. After the reaction was completed, it was cooled to 30°C, and the pH was adjusted to 7.5 with 20% sodium hydroxide aqueous solution. The deionized water was removed by vacuum distillation to obtain poly α-olefin sodium sulfonate. After testing, the CMC value was 6.2×10 -2 mol / L.

[0036] Example 1: A spray composite disinfectant, the specific preparation steps are: according to the ratio of each group in Table 1, add the disinfectant and wetting agent to the solvent, disperse evenly, then add the synergist, moisturizing aid, and water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0037] In this embodiment, the disinfectant is didecyldimethylammonium chloride, the enhancer is p-hydroxyacetophenone, the moisturizing aid is 1,2-propylene glycol, the solvent is ethanol, the water is drinking purified water, and the wetting agent is the poly-α-olefin sodium sulfonate prepared in the preparation example.

[0038] Example 2: A spray composite disinfectant, the specific preparation steps are: according to the ratio of each group in Table 1, add the disinfectant and wetting agent to the solvent, disperse evenly, then add the synergist, moisturizing aid, and water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0039] In this embodiment, the disinfectant is didecyl dimethyl ammonium chloride, the enhancer is propylene glycol, the moisturizing agent is urea, the solvent is ethylene glycol, the water is drinking purified water, and the wetting agent is the poly α-olefin sodium sulfonate prepared in the preparation example.

[0040] Example 3: A spray composite disinfectant, the specific preparation steps are: according to the ratio of each group in Table 1, add the disinfectant and wetting agent to the solvent, disperse evenly, then add the synergist, moisturizing aid, and water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0041] In this embodiment, the disinfectant is a mixture of didodecyl quaternary ammonium salt and didecyl dimethyl ammonium chloride in a ratio of 1:1, the enhancer is p-hydroxyacetophenone, the moisturizing aid is 1,2-propylene glycol, the solvent is ethanol, the water is drinking purified water, and the wetting agent is the poly alpha olefin sulfonate sodium prepared in the preparation example.

[0042] Example 4: A spray composite disinfectant: The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the amounts of raw materials in the formula are different. For specific amounts, see Table 1.

[0043] Example 5: A spray composite disinfectant: The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the amounts of raw materials in the formula are different. For specific amounts, see Table 1.

[0044] Example 6: A spray composite disinfectant: The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the amounts of raw materials in the formula are different. For specific amounts, see Table 1.

[0045] Example 7: A spray composite disinfectant: The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the amounts of raw materials in the formula are different. For specific amounts, see Table 1.

[0046] Table 1 Comparative Example 1: A spray composite disinfectant, which differs from Example 1 in that sodium α-olefin sulfonate is used to replace the poly sodium α-olefin sulfonate in Example 1.

[0047] Comparative Example 2: A spray composite disinfectant, which differs from Example 1 in that sodium dodecyl sulfate is used to replace the sodium poly-α-olefin sulfonate in Example 1.

[0048] Comparative Example 3: A spray composite disinfectant, which differs from Example 1 in that fatty alcohol polyoxyethylene ether AEO-9 is used to replace the sodium poly-α-olefin sulfonate in Example 1.

[0049] Test 1. Appearance stability test: The composite disinfectants prepared in each embodiment and comparative example were placed in a sealed container, placed in a 54°C constant temperature box, and observed after 14 days. Qualified: No color change, uniform, clear and transparent state, no precipitation or suspension, and good appearance stability.

[0050] Test 2, foaming test: Take 25 mL of the composite disinfectant prepared in each example into a 100 mL stoppered measuring cylinder, vibrate 30 times at a speed of 2 times / S, and then let it stand for 5 minutes, observe the volume V of the foam, and record the results in Table 2 below.

[0051] Test 3, chicken house disinfection test: The chicken house with a length, width and height of 100m×10m×3.3m is used as the disinfection area. The disinfection operation is carried out by artificial spraying. Walk forward along the long road of the chicken house first, with the nozzle facing down to disinfect the ground for 2 minutes, then turn back, swing the nozzle up and down, and disinfect the walls and equipment for 3 minutes. Sampling: The natural sedimentation method is used for sampling. Nutrient agar culture dishes are placed diagonally in the chicken house. The sampling time is 5 minutes. The culture dishes are placed in a 37℃ constant temperature incubator. After 24 hours of incubation, the total number of bacteria is recorded. Calculate the sterilization rate of the disinfectant and record it in Table 2. Sterilization rate (%) = (colony count before disinfection - colony count after disinfection) / colony count before disinfection × 100%. Sterilization rate> 0 indicates that the content of air microorganisms decreases after disinfection; sterilization rate < 0 indicates that the content of air microorganisms increases after disinfection.

[0052] Table 2 It can be seen from the test results in Table 2 that the selection of wetting agent has a significant impact on the air disinfection effect. It can be seen from the test results of Comparative Examples 1-3 that for the manual disinfection method in livestock and poultry houses, the general disinfectant-surfactant system will cause the content of air microorganisms to increase instead of decrease in a short period of time. The embodiment of the present application uses sodium poly-α-olefin sulfonate as a wetting agent, which has good dispersibility and good dust wetting effect, thereby solving this problem. It can be seen from the test results of Examples 1-3 that although sodium poly-α-olefin sulfonate can solve the problem of the increase of air microorganisms in a short period of time after disinfection, the selection of different disinfectants determines the final bactericidal effect of the spray composite disinfectant, because a more appropriate choice can be made based on the cost of the disinfectant and the effect of the disinfectant on the human body and livestock and poultry.

[0053] Comparing the test results of Examples 1, 4-7, it can be seen that the dosage of the wetting agent is preferably controlled at 10-15%, and the optimal dosage is 12%. This is because when the dosage is low, the wetting and dispersibility of sodium poly-α-olefin sulfonate plays a limited role, making it difficult for the composite disinfectant to quickly wet the dust when sprayed; and as the dosage increases, the foaming phenomenon of sodium poly-α-olefin sulfonate becomes stronger and stronger, and for spray composite disinfection, the strong foaming property will instead affect the sterilization and disinfection effect in the air, because stirring is required during on-site preparation, and the foam cannot dissipate in a short time. When the spray disinfection is working, droplets will be generated, resulting in poor disinfection effect, and the content of microorganisms in the air is still on the rise.

[0054] The above is only the preferred implementation of the present application. The protection scope of the present application is not limited to the above embodiments. All technical solutions under the concept of the present application belong to the protection scope of the present application. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present application should also be regarded as the protection scope of the present application.

Claims

1. A preparation process of a spray composite disinfectant, characterized in that: Measured in mass percentage, the raw materials for preparing the composite disinfectant include 5-10% disinfectant, 10-15% wetting agent, 5-10% synergist, 5-10% moisturizing aid, 5-10% solvent, and the remainder water. The specific preparation steps are: add the disinfectant and the wetting agent to the solvent, disperse them evenly, then add the synergist, moisturizing aid, and water, and disperse them evenly. The wetting agent is poly α-olefin sulfonate.

2. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The poly-α-olefin sulfonate is sodium poly-α-olefin sulfonate, and the carbon chain length of the sodium poly-α-olefin sulfonate is C 12 -C 20 .

3. The preparation process of the spray composite disinfectant according to claim 2, characterized in that: The carbon chain length of the poly-α-olefin sulfonate sodium is C 14 -C 16 .

4. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: Calculated in percentage by mass, the raw materials of the composite disinfectant include: 10% disinfectant, 12% wetting agent, 8% synergist, 8% moisturizing aid, 8% solvent, and 54% water.

5. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The disinfectant is at least one of quaternary ammonium salt compounds, slightly acidic electrolyzed water, peroxide compounds, and biguanide compounds.

6. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The synergist is one or a mixture of two or more of propylene glycol, pentylene glycol, decyl glycol and p-hydroxyacetophenone.

7. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The moisturizing auxiliary agent is at least one of sorbitol, xylitol, urea, 1,2-propylene glycol, polypropylene glycol and glycerol.

8. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The solvent is at least one of water, ethanol, ethylene glycol, propylene glycol and glacial acetic acid.

9. The preparation process of the spray composite disinfectant according to claim 1, characterized in that: The spray composite disinfectant can be used directly or after being diluted with water. When diluted with water, the dilution ratio V / V is 1: (50-100).

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