Photomagnetic integrated blood coagulation analyzer

Abstract

The invention provides a photomagnetic integrated blood coagulation analyzer which is characterized in that a first coil and a second coil are oppositely arranged at a first mounting position and a third mounting position of a paramagnetic particle method test position, and a light-emitting part and a detection part are oppositely arranged at a second mounting position and a fourth mounting position of the paramagnetic particle method test position; according to the method, the first coil and the second coil are arranged in the sample cup, the light emitting part is arranged in the sample cup, a light signal emitted by the light emitting part is detected through the detection part, then rotation of the magnetic beads in the sample cup driven by the first coil and the second coil is monitored, and then the light signal emitted by the light emitting part is detected through the detection part. According to the present invention, the time for blocking the transmission light through the light through hole in the magnetic bead swinging process is obtained, and the time for the magnetic bead to swing from the swinging state to the static swinging state can be obtained through calculation and analysis, and can be adopted as the solidification time, such that compared with the existing double-magnetic-circuit magnetic bead method, the driving coil does not affect the light emitting detection device so as to provide the light emitting detection device with the light emitting detection device; and the accuracy of a final test result can be effectively ensured.

Description

Technical Field

[0001] The present invention relates to the field of medical instruments, and in particular to an optical-magnetic integrated coagulation analyzer. Background Art

[0002] The coagulation analyzer is a special instrument for thrombosis and hemostasis analysis. It can detect a variety of thrombosis and hemostasis indicators, providing valuable indicators for the diagnosis of bleeding and thrombotic diseases, thrombolytic and anticoagulant therapy monitoring, and efficacy observation. It is an essential in vitro detection equipment in clinical practice.

[0003] Existing coagulation analyzers generally use a dual magnetic circuit test method, that is, four coils are set around the test cup, two relative drive coils and two relative induction coils. Plasma and special demagnetized small steel balls are added to the test cup. First, the two drive coils are alternately energized. The coils generate a magnetic field due to electromagnetic induction, and the magnetic beads are magnetized in the field. The magnetic field causes the magnetic beads to move back and forth periodically at the bottom of the cup (which can fully mix the sample to be tested and the reagent), thereby cutting the magnetic flux lines, causing the magnetic flux in the two relative induction coils next to the test cup to change, and generating an induced current. The faster the cutting movement of the magnetic beads, the greater the intensity of the induced current. After adding the coagulation reagent (the reagent covers the steel balls moving at the bottom of the cup), the number of fibrin clots increases, the plasma viscosity increases, and the magnetic beads are more affected by the fluid resistance, the movement speed slows down, and the current in the induction coil also decreases. Therefore, the change in the induced current can be used to determine whether the blood is coagulated. The coagulation time is the time taken when the amplitude is weakened to 50%, and different magnetic field strengths can be selected according to different test items.

[0004] However, the existing dual magnetic circuit test method will have alternating magnetic field interference, that is, the driving coil affects the induction coil, which in turn affects the final test results. Therefore, there is an urgent need for a coagulation analyzer with a simple structure that can accurately test multiple thrombosis and hemostasis indicators. Summary of the invention

[0005] In view of this, an embodiment of the present invention provides an optical-magnetic integrated coagulation analyzer to solve the problem that the dual magnetic circuit test method of the existing coagulation analyzer may have alternating magnetic field interference, resulting in inaccurate final test results.

[0006] To achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0007] An optical-magnetic integrated coagulation analyzer, comprising: a housing, a magnetic bead detection module, a display module and a processor;

[0008] The shell is provided with a magnetic bead method test position for placing the sample cup, and a first mounting position, a second mounting position, a third mounting position and a fourth mounting position are provided along the circumference of the magnetic bead method test position, wherein the first mounting position is symmetrical with the third mounting position, and the second mounting position is symmetrical with the fourth mounting position;

[0009] The magnetic bead method detection module includes a first coil, a second coil, a light emitting element and a detection element;

[0010] The first coil and the second coil are arranged oppositely at the first installation position and the third installation position of the magnetic bead method test position;

[0011] The light emitting component and the detection component are arranged at the second installation position and the fourth installation position of the magnetic bead method test position opposite to each other, and the detection component is used to detect the light signal emitted by the light emitting component;

[0012] The detection component and the display module are both connected to the processor for communication. The detection component sends the collected signal to the processor for processing, and the processor is used to send the processed information to the display module for display.

[0013] Preferably, the light emitting element is an infrared light emitter.

[0014] Preferably, it also includes: an optical detection module;

[0015] The optical detection module includes a light shielding cap, a detection light source and a photoelectric receiver;

[0016] The housing is provided with an optical method testing position for placing a sample cup;

[0017] The detection light source and the photoelectric receiver are respectively arranged on both sides of the optical method test position, and the photoelectric receiver is connected to the processor for communication. The photoelectric receiver is used to send the collected signal to the processor for processing, wherein the wavelength of the detection light source is 405nm or 660nm;

[0018] The light shielding cap can be opened and closed and set at the optical method test position.

[0019] Preferably, it also includes: a constant temperature module for preheating samples in the optical detection module and the magnetic bead detection module;

[0020] The constant temperature module is arranged on the shell.

[0021] Preferably, the housing is provided with a plurality of pre-temperature positions for placing samples;

[0022] The constant temperature module is also used to heat the samples in the pre-temperature position.

[0023] Preferably, it also includes: thermal insulation cotton set at the pre-heating position.

[0024] Preferably, the constant temperature module comprises: a temperature sensor, a thermal protector and a heating element;

[0025] The heating element and temperature sensor are both set at the pre-temperature position;

[0026] The heating element is connected to the power supply;

[0027] The thermal protector is arranged between the heating element and the power supply and is communicated with the temperature sensor. The heating element is used to heat the sample at the pre-temperature position. The temperature sensor is used to detect the temperature of the sample at the pre-temperature position in real time. The thermal protector can disconnect the heating element from the power supply when the temperature of the sample at the pre-temperature position reaches a preset value.

[0028] Preferably, it also includes: a magnetic stirrer and an electromagnet;

[0029] The electromagnet is set at the pre-temperature position;

[0030] The magnetic stirring bar is set in the sample cup at the preheated position.

[0031] Preferably, it also includes: a pipette for adding reagents.

[0032] Preferably, it also includes: a magnetic bead adder for adding magnetic beads.

[0033] Preferably, it also includes: a mixing module for mixing the sample;

[0034] The shell is provided with a mixing position for placing the sample;

[0035] The mixing module is arranged at the mixing position.

[0036] Preferably, the mixing module comprises: a base, a motor, a sensor, an eccentric shaft, a cup holder, a bearing and a controller;

[0037] The motor is arranged on the base;

[0038] The eccentric shaft is vertically arranged at the output end of the motor;

[0039] The lower end of the cup seat is movably connected to the upper end of the eccentric shaft through a bearing. The cup seat is used to carry the sample cup, and the rotation of the eccentric shaft is used to drive the cup seat to vibrate.

[0040] The sensor is arranged on one side of the cup holder, and is used to detect whether a sample cup is carried in the cup holder;

[0041] The controller is electrically connected to the sensor and the motor, and is used to control the motor to start, and control the motor to stop after the motor starts for a preset time period.

[0042] Preferably, it also includes: a printing module;

[0043] The printing module is arranged on the shell body, and the printing module is connected with the processor.

[0044] Preferably, it also includes: a communication module for connecting to external communication;

[0045] The communication connection module is communicatively connected with the processor.

[0046] Preferably, the communication module includes: any one or more of a wireless communication module, a wired communication module, a barcode scanner and a card reader module;

[0047] The wireless communication module is used for connecting with external wireless communication;

[0048] The wired communication module is used for communication connection with an external network cable;

[0049] The barcode scanner is used to scan barcodes;

[0050] The card reader module is used to obtain the information of the IC card.

[0051] Preferably, it also includes: a speaker arranged on the shell.

[0052] Preferably, it further comprises: an exhaust fan arranged on the shell.

[0053] Preferably, it also includes: a USB interface for USB insertion arranged on one side of the shell.

[0054] Based on the optical-magnetic integrated coagulation analyzer provided by the present invention, the first coil and the second coil are relatively arranged on the left and right sides of the magnetic bead method test position, and the light-emitting component and the detection component are relatively arranged on the front and rear sides of the magnetic bead method test position, and the light signal emitted by the light-emitting component is detected by the detection component, and then the first coil and the second coil drive the magnetic beads in the sample cup to rotate, and then the light signal emitted by the light-emitting component is detected by the detection component. Since the magnetic bead method of the present application uses a pair of coils for driving the magnetic beads to swing and a pair of light-emitting detection devices to measure the swinging state of the magnetic beads to monitor the changes in viscosity and fluidity of the reaction system, that is, by obtaining the time when the magnetic beads block the transmitted light through the light-transmitting hole during the swinging process, the time from the swinging of the magnetic beads to the swinging tending to be stationary can be calculated and analyzed, which can be used as the coagulation time. Compared with the existing dual-magnetic circuit magnetic bead method, the present application can effectively ensure the accuracy of the final test result because the driving coil will not affect the light-emitting detection device. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0056] Figure 1 A front view of an optical-magnetic integrated coagulation analyzer provided in an embodiment of the present invention;

[0057] Figure 2 A schematic diagram of one side of an optical-magnetic integrated coagulation analyzer provided in an embodiment of the present invention;

[0058] Figure 3 A schematic diagram of another side of the optical-magnetic integrated coagulation analyzer provided in an embodiment of the present invention;

[0059] Figure 4 A schematic diagram of another side of the optical-magnetic integrated coagulation analyzer provided in an embodiment of the present invention;

[0060] Figure 5 A partial enlarged view of the optical-magnetic integrated coagulation analyzer provided in an embodiment of the present invention;

[0061] Figure 6 A schematic diagram of the structure of a constant temperature module provided in an embodiment of the present invention;

[0062] Figure 7 A schematic diagram of the structure of a mixing module provided in an embodiment of the present invention;

[0063] Figure 8 A schematic diagram of the principle structure of a magnetic bead detection module provided in an embodiment of the present invention.

[0064] Among them, the shell 1, the magnetic bead method test position 1-1, the optical method test position 1-2, the pre-heating position 1-3, the mixing position 1-4, the magnetic bead method detection module 2, the first coil 2-1, the second coil 2-2, the light-emitting component 2-3, the detection component 2-4, the display module 3, the optical method detection module 4, the shading cap 4-1, the detection light source 4-2, the photoelectric receiver 4-3, the pipette 5, the magnetic bead sampler 6, the mixing module 7, the base 7-1, the motor 7-2, the sensor 7-3, the eccentric shaft 7-4, the cup holder 7-5, the printing module 8, the wired communication module 9-1, the barcode scanner 9-2, the card reader module 9-3, the speaker 10, the exhaust fan 11, the USB interface 12, the temperature sensor 13-1, the thermal protector 13-2, and the heating component 13-3. DETAILED DESCRIPTION

[0065] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0066] In this application, the terms "comprises", "comprising" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprising a ..." does not exclude the presence of other identical elements in the process, method, article or device comprising the element.

[0067] The embodiment of the present invention provides an optical-magnetic integrated coagulation analyzer, see Figures 1 to 8 , Figure 1 The structure diagram of the optical-magnetic integrated coagulation analyzer is shown in FIG. 1 , which comprises: a housing 1 , a magnetic bead detection module 2 , a display module 3 and a processor;

[0068] The housing 1 is provided with a magnetic bead method test position 1-1 for placing a sample cup, and a first mounting position, a second mounting position, a third mounting position and a fourth mounting position are provided along the circumference of the magnetic bead method test position, wherein the first mounting position is symmetrical with the third mounting position, and the second mounting position is symmetrical with the fourth mounting position;

[0069] The magnetic bead detection module 2 includes a first coil 2-1, a second coil 2-2, a light emitting element 2-3 and a detection element 2-4;

[0070] The first coil 2-1 and the second coil 2-2 are arranged at the first installation position and the third installation position of the magnetic bead method test position 1-1 relative to each other;

[0071] The light emitting element 2-3 and the detection element 2-4 are arranged at the second installation position and the fourth installation position of the magnetic bead method test position 1-1, and the detection element 2-4 is used to detect the light signal emitted by the light emitting element 2-3;

[0072] The detection element 2 - 4 and the display module 3 are both connected to the processor for communication. The detection element 2 - 4 sends the collected signal to the processor for processing, and the processor is used to send the processed information to the display module 3 for display.

[0073] It should be noted that the magnetic bead detection module 2 of the present application is implemented based on the coagulation method, which mainly simulates the physiological blood coagulation conditions, and starts the blood coagulation reaction by adding the corresponding reagents, so that the fibrinogen in the sample is converted into cross-linked fibrin, and the sample is coagulated. Then, the reaction coagulation time is determined by continuously monitoring the changes in the physical (viscosity and fluidity) characteristics of the reaction system during this process, and is used as the conversion time of fibrinogen. This principle is used to determine the coagulation characteristics or fibrinolytic characteristics of the blood sample.

[0074] In the present application, the first coil 2-1 and the second coil 2-2 are relatively arranged at the first installation position and the third installation position of the magnetic bead method test position 1-1, and the light-emitting component 2-3 and the detection component 2-4 are relatively arranged at the second installation position and the fourth installation position of the magnetic bead method test position 1-1, and the light signal emitted by the light-emitting component 2-3 is detected by the detection component 2-4, and then the magnetic beads in the sample cup are driven to rotate by the first coil 2-1 and the second coil 2-2, and then the light signal emitted by the light-emitting component 2-3 is detected by the detection component 2-4. Since the magnetic bead method of the present application uses a pair of coils for driving the magnetic beads to swing and a pair of light-emitting detection devices to measure the swinging state of the magnetic beads to monitor the changes in the viscosity and fluidity of the reaction system, that is, by obtaining the time when the magnetic beads block the transmitted light through the light-transmitting hole during the swinging process, the time from the swinging to the stationary swinging of the magnetic beads can be obtained by calculation and analysis, which can be used as the solidification time. Compared with the existing dual-magnetic circuit magnetic bead method, the present application can effectively ensure the accuracy of the final test result because the driving coil will not affect the light-emitting detection device.

[0075] Specifically, the light emitting element 2 - 3 is an infrared light emitter.

[0076] It should be noted that the light emitting element 2 - 3 may be an infrared light emitting device or other types of light emitting devices, and those skilled in the art may select the light emitting device according to their needs.

[0077] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: an optical detection module 4;

[0078] The optical detection module 4 includes a light shielding cap 4-1, a detection light source 4-2 and a photoelectric receiver 4-3;

[0079] The housing 1 is provided with optical method test positions 1-2 for placing sample cups;

[0080] The detection light source 4-2 and the photoelectric receiver 4-3 are respectively arranged on both sides of the optical method test position 1-2, and the photoelectric receiver 4-3 is connected to the processor for communication. The photoelectric receiver 4-3 is used to send the collected signal to the processor for processing, wherein the wavelength of the detection light source 4-2 is 405nm or 660nm;

[0081] The light shielding cap 4 - 1 can be opened and closed and is disposed at the optical method testing position 1 - 2 .

[0082] It should be noted that, by setting up an optical detection module 4, and setting up an optical test position 1-2 for placing a sample cup on the shell 1, the detection light source 4-2 and the photoelectric receiver 4-3 of the optical detection module 4 are respectively set on both sides of the magnetic bead test position, and the wavelength of the detection light source 4-2 is set to 405nm or 660nm, and the light-shielding cap 4-1 is openably set on the shell 1 of the optical test position 1-2, it is possible to effectively prevent external light from interfering with the detection of the optical detection module 4.

[0083] The detection light source 4-2 with a wavelength of 405 nm in the present application is mainly used for the detection of chromogenic substrate method items, while the detection light source 4-2 with a wavelength of 660 nm is mainly used for the detection of coagulation method items and immunoturbidimetry item detection.

[0084] It should also be noted that since the optical detection module 4 detects the sample coagulation process, the optical detection module 4 has large measurement errors or is unable to detect samples of lipemia, jaundice, and hemolysis. Since the present application is provided with a magnetic bead detection module 2, when detecting samples of lipemia, jaundice, and hemolysis, the magnetic bead detection module 2 of the present application can be used for detection.

[0085] It is worth noting that the photoelectric receiver 4-3 of the optical detection module 4 of the present application generates a corresponding electrical signal through the light intensity of the received detection light source 4-2. The processor processes the signal sent by the photoelectric receiver 4-3 to obtain the required detection result, which is finally displayed through the display module 3.

[0086] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a constant temperature module for preheating samples in the optical detection module 4 and the magnetic bead detection module 2;

[0087] The constant temperature module is arranged on the housing 1 .

[0088] It should be noted that by providing a constant temperature module for preheating the samples in the optical detection module 4 and the magnetic bead detection module 2, not only can the temperature of the samples be kept constant during the test, but the samples can also be preheated before the sample detection.

[0089] Specifically, the housing 1 is provided with a plurality of pre-temperature positions 1-3 for placing samples;

[0090] The constant temperature module is also used to heat the samples in pre-temperature positions 1-3.

[0091] It should be noted that by setting the pre-temperature positions 1-3 in the housing 1, the constant temperature module can pre-heat the sample through the pre-temperature positions 1-3 when testing at the magnetic bead test position and the optical method test position 1-2.

[0092] Furthermore, the optical-magnetic integrated coagulation analyzer also includes: thermal insulation cotton arranged at pre-temperature positions 1-3.

[0093] It should be noted that by arranging thermal insulation cotton at the pre-heating positions 1-3, the heat loss at the pre-heating positions 1-3 can be reduced, the sample temperature can be ensured and a certain energy-saving effect can be achieved.

[0094] Specifically, the constant temperature module includes: a temperature sensor 13-1, a thermal protector 13-2 and a heating element 13-3;

[0095] The heating element 13-3 and the temperature sensor 13-1 are both arranged at the pre-temperature position 1-3;

[0096] The heating element 13-3 is connected to a power source;

[0097] The thermal protector 13-2 is arranged between the heating element 13-3 and the power supply, and is communicated with the temperature sensor 13-1. The heating element 13-3 is used to heat the sample at the pre-heating position 1-3, and the temperature sensor 13-1 is used to detect the temperature of the sample at the pre-heating position 1-3 in real time. The thermal protector 13-2 can disconnect the heating element 13-3 from the power supply when the temperature of the sample at the pre-heating position 1-3 reaches a preset value.

[0098] It should be noted that the heating element 13-3 and the temperature sensor 13-1 are both set at the pre-heating position 1-3, the heating element 13-3 is connected to the power supply, the thermal protector 13-2 is set between the heating element 13-3 and the power supply, and is communicated with the temperature sensor 13-1, the heating element 13-3 is used to heat the sample at the pre-heating position 1-3, the temperature sensor 13-1 detects the temperature of the sample at the pre-heating position 1-3 in real time, and the thermal protector 13-2 can disconnect the heating element 13-3 from the power supply when the temperature of the sample at the pre-heating position 1-3 reaches a preset value, thereby being able to accurately control the temperature of the sample to be constant (such as 37.0℃±1℃), effectively avoiding damage to the sample due to excessive temperature.

[0099] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a magnetic stirrer and an electromagnet;

[0100] The electromagnet is set at pre-temperature position 1-3;

[0101] The magnetic stirring bar is set in the sample cup at the preheating position 1-3.

[0102] It should be noted that by setting up a magnetic stirrer and an electromagnet, according to the principle that like charges repel and opposite charges attract, the electromagnet generates a changing magnetic field. Since the magnetic field in the sample cup is changing, the magnetic stirrer in the sample cup will rotate in the changing magnetic field, and the rotation of the magnetic stirrer can stir the reagent in the sample cup.

[0103] It should also be noted that the above-mentioned sample cup can be a sample cup, a reaction cup, or a blood coagulation cup. Those skilled in the art can select the corresponding sample cup according to their needs.

[0104] Preferably, the magnetic stirrer is usually a small rod or blade made of stainless steel, NdFeB permanent magnet material or other magnetic materials.

[0105] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a pipette 5 for adding reagents.

[0106] It should be noted that by providing a pipette 5 for adding reagents, it is convenient for the staff to add samples and reagents.

[0107] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a magnetic bead adder 6 for adding magnetic beads.

[0108] It should be noted that, by providing a magnetic bead adder 6 for adding magnetic beads, it is convenient for the staff to add magnetic beads during the test process.

[0109] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a mixing module 7 for mixing the sample;

[0110] The housing 1 is provided with mixing positions 1-4 for placing samples;

[0111] The mixing module 7 is arranged at the mixing positions 1-4.

[0112] It should be noted that, by providing a mixing module 7 for mixing the sample, after adding the reagent to the sample, the sample can be mixed by the mixing module 7, thereby greatly improving the sample detection efficiency.

[0113] Specifically, the mixing module 7 includes: a base 7-1, a motor 7-2, a sensor 7-3, an eccentric shaft 7-4, a cup holder 7-5, a bearing and a controller;

[0114] The motor 7-2 is arranged on the base 7-1;

[0115] The eccentric shaft 7-4 is vertically arranged at the output end of the motor 7-2;

[0116] The lower end of the cup seat 7-5 is movably connected to the upper end of the eccentric shaft 7-4 through a bearing. The cup seat 7-5 is used to carry the sample cup, and the rotation of the eccentric shaft 7-4 is used to drive the cup seat 7-5 to vibrate;

[0117] The sensor 7-3 is disposed on one side of the cup holder 7-5 and is used to detect whether a sample cup is carried in the cup holder 7-5;

[0118] The controller is electrically connected to the sensor 7-3 and the motor 7-2, and is used to control the motor 7-2 to start, and to control the motor 7-2 to stop after the motor 7-2 starts for a preset time period.

[0119] It should be noted that the motor 7-2 is arranged on the base 7-1, the eccentric shaft 7-4 is vertically arranged on the output end of the motor 7-2, the lower end of the cup holder 7-5 for carrying the sample cup is movably connected to the upper end of the eccentric shaft 7-4 through a bearing, and the sensor 7-3 for detecting whether the cup holder 7-5 carries the sample cup is arranged on one side of the cup holder 7-5, and the controller for controlling the start and stop of the motor 7-2 is electrically connected to the sensor 7-3 and the motor 7-2. Through the above-disclosed mixing module 7, when the sample cup is placed in the cup holder 7-5, the sample cup can be quickly detected by the sensor 7-3, and the motor 7-2 can be quickly controlled to start through the controller, and the motor 7-2 drives the cup holder 7-5 to vibrate through the eccentric shaft 7-4, thereby realizing fast and automatic shaking, which greatly improves the mixing efficiency.

[0120] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a printing module 8;

[0121] The printing module 8 is disposed in the housing 1 , and the printing module 8 is connected to the processor.

[0122] It should be noted that, by providing the printing module 8 and connecting the printing module 8 to the processor, the final result obtained by the detection can be printed through the printing module 8.

[0123] It should also be noted that the printing module 8 of the present application is mainly composed of a thermal printer, which is based on thermal printing technology, which uses heat energy to convert ink into images. Specifically, a semiconductor heating element is installed on the print head of the thermal printer. When the print head is heated and contacts the thermal printing paper, the required pattern can be printed. The image is generated by heating to produce a chemical reaction in the film of the paper. During use, click on the information to be printed on the display module 3, the information is transmitted to the processor, and the processor sends the information to the thermal printing printing module 8 to execute printing.

[0124] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a communication module for connecting to external communication;

[0125] The communication connection module is communicatively connected with the processor.

[0126] It should be noted that by setting up a communication module connected to the external communication, and connecting the communication connection module to the processor, the information processed by the processor can be uploaded to other locations (such as a server) for storage through the communication module, and the test results can be uploaded in real time.

[0127] Specifically, the communication module includes: any one or more of a wireless communication module, a wired communication module 9-1, a barcode scanner 9-2, and a card reader module 9-3;

[0128] The wireless communication module is used for connecting with external wireless communication;

[0129] The wired communication module 9-1 is used for communication connection with an external network cable;

[0130] The barcode scanner 9-2 is used to scan barcodes;

[0131] The card reading module 9-3 is used to obtain the information of the IC card.

[0132] It should be noted that the wireless communication module can be implemented through technologies such as Bluetooth and 5G technology. Technical personnel in this field can specifically select one or more of them according to their needs, and the wired communication module 9-1 can be connected to the external communication through the network port or RS-232 interface. The scanner 9-2 can obtain the information of the person corresponding to the sample by scanning the QR code or barcode carried on the sample, and the sample information (including the name, gender, age, test items, etc. of the sampled person) can also be quickly entered through the scanner 9-2, effectively improving the detection efficiency of the sample.

[0133] The present application realizes the traceability and management of reagent information by setting up a card reader module 9-3 for obtaining IC card information and identifying the information in the IC card of the reagent used (including reagent type, capacity, production date, etc.) through RFID (Radio Frequency Identification) module.

[0134] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a speaker 10 disposed on the housing 1 .

[0135] It should be noted that by setting up the speaker 10, a preset prompt sound can be played through the speaker 10, such as a prompt sound when the sample detection is completed and a prompt sound when the sample detection is started. The above prompt sound can be a voice broadcast or a regular beep sound.

[0136] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: an exhaust fan 11 disposed on the housing 1 .

[0137] It should be noted that, by providing the exhaust fan 11 , the heat inside the housing 1 can be dissipated in time, thereby preventing the internal temperature of the housing 1 from being too high, thereby preventing the electronic components inside the housing 1 from being damaged.

[0138] Furthermore, the optical-magnetic integrated coagulation analyzer further includes: a USB interface 12 for USB insertion, which is arranged on one side of the housing 1 .

[0139] It should be noted that, by providing a USB interface 12 on one side of the housing 1 , it is convenient for users to copy the test data of their own samples.

[0140] Each of the above modules that have data transmission with external devices is connected to the processor for communication, and the processor controls data sending and receiving.

[0141] Preferably, the optical-magnetic integrated coagulation analyzer is also provided with a power interface connected to an external power source.

[0142] It should be noted that the optical-magnetic integrated coagulation analyzer can be connected to an external power source through a power interface, and various components of the optical-magnetic integrated coagulation analyzer can also be powered by a built-in battery module.

[0143] In order to facilitate the understanding of the optical-magnetic integrated coagulation analyzer provided above, Figures 1 to 5 , for further introduction.

[0144] The optical-magnetic integrated coagulation analyzer comprises four magnetic bead method test positions 1-1 and two optical method test positions 1-2, wherein the wavelength of the detection light source 4-2 of one channel is 405nm and 660nm, and the wavelength of the other detection light source 4-2 is 660nm.

[0145] The optical-magnetic coagulation analyzer also includes 16 sample pre-heating positions 1-3 and 6 reagent positions (such as Figure 1 1-3-1), where the 12 sample preheating positions 1-3 are the magnetic bead reaction cup placement positions (as shown in Figure 1 1-3-2), the four sample pre-heating positions 1-3 are the optical reaction cup placement positions (as shown in Figure 1 1-3-3), the 4 reagent positions are reagent pre-heating positions 1-3 (as shown in Figure 1 3 to 6 normal temperature reagent positions in the reagent), 2 reagent positions are normal temperature reagent positions (such as Figure 1 1 and 2 reagent positions in the sample), and 2 reagent positions can hold 10ml reagent bottles (compatible with 7ml reagent bottles with an adapter), and the 2 reagent pre-temperature positions 1-3 have magnetic stirring function (magnetic stirring bar and electromagnet are used to achieve stirring).

[0146] The optical-magnetic coagulation analyzer also includes a pipette 5 for adding reagents and samples. When adding reagents, by pressing a sample adding button on the pipette 5 , the reagent adding status can be automatically confirmed, and stirring or other test steps can be achieved.

[0147] The optical-magnetic integrated coagulation analyzer also includes a magnetic bead sampler 6 for adding magnetic beads, which includes a magnetic bead pen, a built-in spring, a bead storage pen barrel, and a magnetic bead button, wherein the main body of the magnetic bead pen is made of aluminum alloy, and when the button is pressed once, a magnetic bead will flow out from the bead outlet of the magnetic bead pen. It is arranged on one side of the analyzer.

[0148] The optical-magnetic coagulation analyzer also includes a mixing module 7 for mixing the sample. The mixing module 7 of the present application uses the principle of eccentric rotation and drives the motor 7-2 to cause the liquid in the reaction cup to generate a strong vortex motion, thereby promoting the mixing of the sample and the reagent.

[0149] The display module 3 of the optical-magnetic coagulation analyzer is realized by an 8-inch serial port screen. The serial port screen is an intelligent display terminal based on serial port communication, mainly composed of a touch screen, a TFT liquid crystal display and a control mainboard. The control mainboard is the core of the serial port screen. It consists of MCU, FLASH, interface circuit, power supply and other parts. It is mainly responsible for detecting touch and controlling TFT display, and communicating with the main control circuit board through the serial port.

[0150] The printing module 8 of the optical-magnetic integrated coagulation analyzer is mainly composed of a thermal printer based on thermal printing technology, which uses thermal energy to convert ink into images.

[0151] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can refer to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system or system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can refer to the partial description of the method embodiment. The system and system embodiments described above are merely schematic, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Ordinary technicians in this field can understand and implement it without creative work.

[0152] Professionals may further appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, computer software, or a combination of the two. In order to clearly illustrate the interchangeability of hardware and software, the composition and steps of each example have been generally described in the above description according to function. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professionals and technicians may use different methods to implement the described functions for each specific application, but such implementation should not be considered to be beyond the scope of the present invention.

[0153] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An optical-magnetic integrated coagulation analyzer, characterized in that: include: Housing, magnetic bead detection module, display module and processor; The shell is provided with a magnetic bead method test position for placing a sample cup, and a first mounting position, a second mounting position, a third mounting position and a fourth mounting position are provided along the circumference of the magnetic bead method test position, wherein the first mounting position is symmetrical with the third mounting position, and the second mounting position is symmetrical with the fourth mounting position; The magnetic bead detection module includes a first coil, a second coil, a light emitting element and a detection element; The first coil and the second coil are arranged oppositely at the first installation position and the third installation position of the magnetic bead method testing position; The light emitting component and the detection component are arranged at the second installation position and the fourth installation position of the magnetic bead method test position opposite to each other, and the detection component is used to detect the light signal emitted by the light emitting component; The detection component and the display module are both connected to the processor for communication. The detection component sends the collected signal to the processor for processing, and the processor is used to send the processed information to the display module for display.

2. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: The light emitting element is an infrared light emitting device.

3. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: Optical detection module; The optical detection module includes a light shielding cap, a detection light source and a photoelectric receiver; The housing is provided with an optical method testing position for placing a sample cup; The detection light source and the photoelectric receiver are respectively arranged on both sides of the optical method test position, and the photoelectric receiver is connected to the processor for communication, and the photoelectric receiver is used to send the collected signal to the processor for processing, wherein the wavelength of the detection light source is 405nm or 660nm; The light shielding cap can be opened and closed and is disposed at the optical method testing position.

4. The optical-magnetic integrated coagulation analyzer according to claim 3, characterized in that: Also includes: A constant temperature module for preheating samples in the optical detection module and the magnetic bead detection module; The constant temperature module is arranged on the shell.

5. The optical-magnetic integrated coagulation analyzer according to claim 4, characterized in that: The housing is provided with a plurality of pre-temperature positions for placing samples; The constant temperature module is also used to heat the sample at the pre-temperature position.

6. The optical-magnetic integrated coagulation analyzer according to claim 5, characterized in that: Also includes: The heat preservation cotton is arranged at the said pre-heating position.

7. The optical-magnetic integrated coagulation analyzer according to claim 5, characterized in that: The constant temperature module includes: a temperature sensor, a thermal protector and a heating element; The heating element and the temperature sensor are both arranged at the pre-temperature position; The heating element is connected to a power source; The thermal protector is arranged between the heating element and the power supply and is communicatively connected with the temperature sensor. The heating element is used to heat the sample at the pre-temperature position. The temperature sensor is used to detect the temperature of the sample at the pre-temperature position in real time. The thermal protector can disconnect the heating element from the power supply when the temperature of the sample at the pre-temperature position reaches a preset value.

8. The optical-magnetic integrated coagulation analyzer according to claim 5, characterized in that: Also included: a magnetic stirrer and an electromagnet; The electromagnet is arranged at the pre-temperature position; The magnetic stirrer is arranged in the sample cup at the pre-heating position.

9. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: Pipette for adding reagents.

10. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: Magnetic bead pipette for adding magnetic beads.

11. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: A mixing module for mixing the sample; The housing is provided with a mixing position for placing the sample; The mixing module is arranged at the mixing position.

12. The optical-magnetic integrated coagulation analyzer according to claim 11, characterized in that: The mixing module includes: a base, a motor, a sensor, an eccentric shaft, a cup holder, a bearing and a controller; The motor is arranged on the base; The eccentric shaft is vertically arranged at the output end of the motor; The lower end of the cup seat is movably connected to the upper end of the eccentric shaft through the bearing, the cup seat is used to carry the sample cup, and the rotation of the eccentric shaft is used to drive the cup seat to vibrate; The sensor is arranged at one side of the cup holder, and is used to detect whether a sample cup is carried in the cup holder; The controller is electrically connected to the sensor and the motor, and is used to control the motor to start, and control the motor to stop after the motor starts for a preset time period.

13. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: Print module; The printing module is arranged on the housing, and the printing module is connected to the processor.

14. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: A communication module for connecting to external communication; The communication connection module is communicatively connected to the processor.

15. The optical-magnetic integrated coagulation analyzer according to claim 14, characterized in that: The communication module includes: any one or more of a wireless communication module, a wired communication module, a barcode scanner and a card reader module; The wireless communication module is used for connecting with external wireless communication; The wired communication module is used to communicate with an external network cable; The barcode scanner is used to scan barcodes; The card reading module is used to obtain the information of the IC card.

16. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: A speaker is arranged on the housing.

17. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: An exhaust fan is arranged on the housing.

18. The optical-magnetic integrated coagulation analyzer according to claim 1, characterized in that: Also includes: A USB interface for USB insertion is arranged on one side of the housing.

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