Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof, and relates to the technical field of medicines. The traditional Chinese medicine composition comprises the following raw materials: dandelion, oldenlandia diffusa, bighead atractylodes rhizome, poria cocos, coix seed, fructus amomi, fingered citron, orange peel, endothelium corneum gigeriae galli, hawthorn, fried malt, semen raphani, pig nail, purple cabbage and hericium erinaceus. The product of the formula has the effects of resisting inflammation and repairing gastric mucosa, so that inflammation marks such as hyperemia, edema and erosion of the gastric mucosa are relieved or eliminated, atrophic lesions of the gastric mucosa are improved or reversed, cell regeneration and digestive tract flora balance are facilitated, and the effect of resisting helicobacter pylori is achieved. The traditional Chinese medicine composition has a very good curative effect on chronic atrophic gastritis in clinical application, takes effect quickly and does not relapse.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. Background Art

[0002] Atrophic gastritis, also known as chronic atrophic gastritis, is a chronic digestive disease characterized by atrophy of the gastric mucosal epithelium and glands. In this disease, the gastric mucosa becomes thinner and the mucosal base thickens, which may be accompanied by pyloric metaplasia and intestinal metaplasia, or atypical hyperplasia. The disease usually manifests as upper abdominal pain, fullness, belching, loss of appetite, or weight loss, anemia, etc. The causes are diverse, such as Helicobacter pylori infection, eating habits, immune factors, bile or duodenal fluid reflux, etc. Middle-aged and elderly people or those exposed to heavy metals such as lead, mercury, copper and zinc are more susceptible to the disease.

[0003] Symptoms of chronic atrophic gastritis include fullness and pain in the epigastric region, heartburn and indigestion, abnormal bowel movements and weakness, anemia, etc. In addition, atrophic gastritis is more likely to be complicated by gastric ulcers, gastric bleeding, anemia, etc. Since the symptoms and signs are non-specific, diagnosis mainly relies on gastroscopy and gastric mucosal biopsy pathology.

[0004] Chronic atrophic gastritis can usually be improved through diet therapy, anti-Helicobacter pylori therapy, gastric mucosal protection therapy, improving gastric motility, acid-resistant therapy, etc. At present, there are many Chinese patent medicines on the market for improving chronic atrophic gastritis. These medicines have certain efficacy. After years of clinical application and observation, these medicines have curative effects, but their effects on treating chronic atrophic gastritis, especially killing Helicobacter pylori, are relatively poor. Summary of the invention

[0005] The purpose of the present application is to provide a Chinese medicine composition for treating chronic atrophic gastritis, which has the effects of resisting Helicobacter pylori and treating chronic atrophic gastritis.

[0006] Another object of the present application is to provide a method for preparing a Chinese medicine composition for treating chronic atrophic gastritis, which is simple and can exert a greater effect of the raw materials.

[0007] In order to solve the above technical problems, the technical solution adopted in this application is:

[0008] On the one hand, the present application provides a traditional Chinese medicine composition for treating chronic atrophic gastritis, comprising the following raw materials: dandelion, oldenlandia diffusa, atractylodes, poria, coix seed, amomum, bergamot, tangerine peel, chicken gizzard lining, hawthorn, roasted malt, radish seed, pig's hoof, purple cabbage and Hericium erinaceus.

[0009] On the other hand, the present application provides a method for preparing a Chinese medicine composition for treating chronic atrophic gastritis, comprising the following steps:

[0010] S1. Grind dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof, Hericium erinaceus and roasted malt into Chinese medicinal powder for later use;

[0011] S2, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract;

[0012] S3. Mix the above-mentioned Chinese medicine powder and extract to make granules, pills, tablets or capsules.

[0013] The present application has the innovation of using old medicines in new ways for various medicinal materials: 1. Pig's hoof nails were originally used to treat cough, wheezing, hemorrhoids, white baldness, and frostbite, and they were ground into powder for oral administration. The present application now uses them to treat chronic atrophic gastritis. The preparation method is original. After the pig's hoof nails are fried with heated sand until they swell, they are soaked in a mixture of aloe juice and vinegar, which can produce the effect of promoting blood circulation and removing blood stasis. 40 patients with chronic atrophic gastritis were clinically observed (the patient selection and evaluation criteria are the same as those in the test example), and they were randomly divided into a treatment group (the first prescription of the present application) and a control group (the first prescription of the present application without the pig's hoof nails). The results after one course of treatment showed that the total effective rate of the treatment group was 90%, and the effective rate of the control group was 70%. The treatment group was better than the control group (P < 0.05), indicating that the preparation of pig's hoof nails has a significant effect on the treatment of chronic atrophic gastritis.

[0014] 2. Chicken gizzard lining was originally used to strengthen the stomach and eliminate food accumulation. After being fried with heated sand, it is soaked in a mixture of aloe juice and vinegar. It can not only correct the bad smell and make the texture crispy and easy to break, but also is good at soothing the liver and assisting the spleen. It is suitable for symptoms of liver and spleen disorders, digestive disorders, and abdominal distension. It can also play a role in inhibiting bacteria and killing bacteria.

[0015] 3. There are three benefits of using aloe vera juice and vinegar together: a. Aloe vera can reduce inflammation and kill bacteria, inhibit inflammation, drain secretions, promote local metabolism, and promote cell regeneration. Vinegar has a sterilizing effect. The combination of the two can enhance the anti-inflammatory and sterilization effects, and has a positive effect on controlling local infections and eliminating local inflammation. b. Aloe vera has the effect of promoting food absorption and digestion, and can help improve the symptoms of loss of appetite and indigestion. The organic acid in vinegar can stimulate the secretion of taste acid, promote gastrointestinal peristalsis, and is conducive to the digestion and absorption of food. The combination of the two can further promote digestive function and improve the problems of loss of appetite and indigestion. c. Regulate the digestive tract flora. The combination of the two can regulate the balance of flora in the digestive tract.

[0016] 4. Purple cabbage belongs to the vegetable category. This application uses it as a raw material because it is rich in sulfide and antioxidants, has a certain inhibitory effect on Helicobacter pylori, and also contains anthocyanins, which is beneficial to the balance of digestive tract flora.

[0017] The medication mechanism of this application: Chronic atrophic gastritis has the closest relationship with the liver and spleen, and the liver and stomach are the two elements of wood and earth. If you are worried and angry, qi stagnation hurts the liver, and the liver qi is rebellious, it is bound to overcome the spleen and attack the stomach, causing qi stagnation, and the stomach is out of harmony and pain. Long-term liver qi stagnation can turn fire into blood stasis, which aggravates stomach pain. The spleen and stomach live together in the abdomen and are in charge of ascending and descending, so stomach disease and spleen, spleen disease and stomach. Based on this, the method of soothing the liver, strengthening the spleen and harmonizing the stomach, and clearing away heat and removing blood stasis is set. In the prescription, bergamot, tangerine peel, and processed chicken gizzard soothe the liver, relieve depression and promote qi; white atractylodes, Poria, and coix seed can strengthen the spleen, nourish the stomach and help transportation; Amomum villosum is aromatic and wakes up the spleen, and is used together with white atractylodes to strengthen the spleen without stagnant qi; dandelion, white flower oldenlandia, and purple cabbage can clear heat; processed pig's hoof and hawthorn can promote blood circulation and remove blood stasis; Lai Mengzi, Hericium erinaceus, and fried malt can help digestion, strengthen the stomach and remove bloating. With this combination, the liver, spleen, and stomach are treated at the same time, Qi will naturally flow smoothly, and the rise and fall will be orderly, and heat and blood stasis will be eliminated, so it is effective for chronic atrophic gastritis.

[0018] Modern pharmacological research shows that Poria cocos and coix seed can both resist inflammation and enhance humoral immunity and cellular immunity, and the latter has analgesic and digestive effects; orange peel can promote the secretion of digestive juices, help digestion, and also have antibacterial and anti-inflammatory effects; Atractylodes macrocephala can enhance the phagocytic function of the reticuloendothelial system and increase the lymphocyte transformation rate; dandelion, oldenlandia diffusa, and purple cabbage have a significant inhibitory and killing effect on Helicobacter pylori (HP), and purple cabbage can resist inflammation and is beneficial to the balance of digestive tract flora; sand Ren and bergamot can strengthen the function of the stomach, promote the secretion of digestive juice, and eliminate gas accumulation in the digestive tract; Hericium erinaceus can improve abdominal distension caused by food accumulation, protect the gastric mucosa, and promote its repair; roasted malt, radish seed, hawthorn, and chicken's gizzard lining can promote the digestive function of the stomach, and hawthorn has a blood-activating effect. After being soaked in a mixture of aloe juice and vinegar, the chicken's gizzard lining has an antibacterial and bactericidal effect, and can regulate the balance of digestive tract flora; after being soaked in a mixture of aloe juice and vinegar, pig's hoof can produce a blood-activating effect.

[0019] The above drugs contain a large amount of mucus, vitamins, proteins, etc. Mucus is acidic and can combine with gastric juice; vitamins can combine with intrinsic factors secreted by parietal cells; proteins can combine with binding acids secreted by gastric glands. Therefore, they can combine with mucus on the surface of gastric mucosa and reach a high concentration in the gastric mucosa layer to effectively remove HP in mucus, inhibit inflammatory reactions, promote the absorption of inflammation, repair of gastric mucosa and cell regeneration.

[0020] Compared with the prior art, the embodiments of the present application have at least the following advantages or beneficial effects:

[0021] The formula product of the application has the effects of anti-inflammatory and repairing gastric mucosa, reducing or eliminating inflammatory markers such as congestion, edema, and erosion of the gastric mucosa, improving or reversing atrophic lesions of the gastric mucosa, being beneficial to cell regeneration and digestive tract flora balance, and having the effect of resisting Helicobacter pylori. In clinical application, it has a very good therapeutic effect on chronic atrophic gastritis, and it takes effect quickly and does not recur. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to the conventional conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0023] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to specific embodiments.

[0024] A Chinese medicine composition for treating chronic atrophic gastritis comprises the following raw materials: dandelion, oldenlandia diffusa, atractylodes macrocephala, tuckahoe, coix seed, amomum villosum, bergamot, tangerine peel, chicken gizzard lining, hawthorn, roasted malt, radish seed, pig's hoof, purple cabbage and hericium erinaceus.

[0025] In some embodiments of the present application, the above-mentioned Chinese medicine composition includes the following raw materials, measured by weight: 5-35 parts of dandelion, 5-35 parts of oldenlandia diffusa, 5-10 parts of Atractylodes macrocephala, 5-30 parts of Poria, 5-30 parts of Coix seeds, 5-6 parts of Amomum villosum, 5-10 parts of bergamot, 5-10 parts of tangerine peel, 5-10 parts of chicken gizzard lining, 5-10 parts of hawthorn, 5-10 parts of roasted malt, 5-15 parts of radish seeds, 5-10 parts of pig's hoof, 5-10 parts of purple cabbage and 5-10 parts of Hericium erinaceus.

[0026] In some embodiments of the present application, the above-mentioned Chinese medicine composition includes the following raw materials, measured by weight: 30 parts of dandelion, 30 parts of oldenlandia diffusa, 10 parts of Atractylodes macrocephala, 20 parts of Poria cocos, 30 parts of Coix seeds, 6 parts of Amomum villosum, 10 parts of bergamot, 10 parts of tangerine peel, 10 parts of chicken gizzard lining, 10 parts of hawthorn, 10 parts of roasted malt, 10 parts of radish seeds, 6 parts of pig's hoof, 10 parts of purple cabbage and 10 parts of Hericium erinaceus.

[0027] A method for preparing a Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:

[0028] S1. Grind dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof, Hericium erinaceus and roasted malt into Chinese medicinal powder for later use;

[0029] S2, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract;

[0030] S3. Mix the above-mentioned Chinese medicine powder and extract to make granules, pills, tablets or capsules.

[0031] In some embodiments of the present application, the prepared chicken's gizzard lining in the above-mentioned step S1 is prepared by the following method: take the chicken's gizzard lining, remove impurities, wash and dry it in the shade, take sand and put it in a pot, heat it until the sand becomes slippery and easy to turn over, then add the chicken's gizzard lining and stir-fry it. When the chicken's gizzard lining turns dark yellow, take it out, sieve out the sand, put it into a mixture of aloe juice and vinegar for immersion and quenching, and obtain it after drying.

[0032] In some embodiments of the present application, the prepared pig's hoof in the above-mentioned step S1 is prepared by the following method: remove impurities from the pig's hoof, wash and dry it, put it into sand heated with high heat, fry it until the pig's hoof is swollen as a whole and golden yellow, sift the sand out, immerse it in a mixture of aloe juice and vinegar, and obtain it after drying.

[0033] In some embodiments of the present application, the mass ratio of vinegar to aloe vera juice in the above-mentioned mixed solution is 15:1.

[0034] In some embodiments of the present application, the mass ratio of the above-mentioned pig hoof nail to the mixed solution is (3-5): 1; the mass ratio of the above-mentioned chicken gizzard lining to the mixed solution is (4-7): 1. The types of aloe that can be used in the present application include Chinese aloe, arborescent aloe, bella aloe, zebra aloe, Chinese aloe and Kura aloe.

[0035] In some embodiments of the present application, the Chinese medicine powder in S1 is sieved through a 100-mesh sieve.

[0036] The features and performance of the present application are further described in detail below in conjunction with the embodiments.

[0037] Example 1

[0038] A Chinese medicine composition for treating chronic atrophic gastritis, the preparation method of which is:

[0039] S1. Weigh the raw materials, by weight: 30 parts of dandelion, 30 parts of oldenlandia diffusa, 10 parts of atractylodes, 20 parts of Poria, 30 parts of coix seeds, 6 parts of Amomum villosum, 10 parts of bergamot, 10 parts of orange peel, 10 parts of chicken gizzard lining, 10 parts of hawthorn, 10 parts of roasted malt, 10 parts of radish seeds, 6 parts of pig's hoof, 10 parts of purple cabbage and 10 parts of Hericium erinaceus;

[0040] S2, get the chicken's gizzard lining and remove impurities, wash and dry in the shade, separately get sand and place in a pot, heat until sand becomes slippery, easily stir, then add the chicken's gizzard lining and stir and fry, take out when the chicken's gizzard lining swells and curls, is crisp and dark yellow, sieve out the sand, put into the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of chicken's gizzard lining and the mixed solution is 5: 1), and obtain the chicken's gizzard lining processed after drying; Pig's hoof is removed of impurities, cleaned and dried, put into the sand heated with high heat, stir-fried until the pig's hoof as a whole swells and is golden yellow, sieve out the sand and take out, be placed in the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of pig's hoof and the mixed solution is 4: 1), and obtain the pig's hoof processed after drying;

[0041] S3, take dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof nail, Hericium erinaceus and fried malt, grind into Chinese medicine powder, pass through 100 mesh sieve for later use;

[0042] S4, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract;

[0043] S5. Mix the above-mentioned Chinese medicine powder and extract to prepare tablets, thereby obtaining the Chinese medicine composition of this embodiment.

[0044] Example 2

[0045] A Chinese medicine composition for treating chronic atrophic gastritis, the preparation method of which is:

[0046] S1. Weigh the raw materials, by weight: 25 parts of dandelion, 20 parts of oldenlandia diffusa, 8 parts of atractylodes, 30 parts of Poria, 25 parts of coix seeds, 5 parts of Amomum villosum, 10 parts of bergamot, 5 parts of tangerine peel, 6 parts of chicken gizzard lining, 5 parts of hawthorn, 5 parts of roasted malt, 15 parts of radish seeds, 8 parts of pig's hoof, 5 parts of purple cabbage and 10 parts of Hericium erinaceus;

[0047] S2, get the chicken's gizzard lining and remove impurities, wash and dry in the shade, separately get sand and place in a pot, heat until sand becomes slippery, easily stir, then add the chicken's gizzard lining and stir and fry, take out when the chicken's gizzard lining swells and curls, is crisp and dark yellow, sieve out the sand, put into the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of chicken's gizzard lining and the mixed solution is 6: 1), and obtain the chicken's gizzard lining processed after drying; Pig's hoof is removed of impurities, cleaned and dried, put into the sand heated with high heat, stir-fried until the pig's hoof as a whole swells and is golden yellow, sieve out the sand and take out, be placed in the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of pig's hoof and the mixed solution is 3: 1), and obtain the pig's hoof processed after drying;

[0048] S3, take dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof nail, Hericium erinaceus and fried malt, grind into Chinese medicine powder, pass through 100 mesh sieve for later use;

[0049] S4, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract;

[0050] S5. Mix the above-mentioned Chinese medicine powder and extract to prepare granules, thereby obtaining the Chinese medicine composition of this embodiment.

[0051] Example 3

[0052] A Chinese medicine composition for treating chronic atrophic gastritis, the preparation method of which is:

[0053] S1. Weigh the raw materials, by weight: 15 parts of dandelion, 35 parts of oldenlandia diffusa, 10 parts of atractylodes, 20 parts of Poria, 20 parts of coix seeds, 6 parts of Amomum villosum, 5 parts of bergamot, 10 parts of tangerine peel, 5 parts of chicken gizzard lining, 10 parts of hawthorn, 10 parts of roasted malt, 5 parts of radish seeds, 10 parts of pig's hoof, 8 parts of purple cabbage and 8 parts of Hericium erinaceus;

[0054] S2, get the chicken's gizzard lining and remove impurities, wash and dry in the shade, separately get sand and place in a pot, heat until sand becomes slippery, easily stir, then add the chicken's gizzard lining and stir and fry, take out when the chicken's gizzard lining swells and curls, is crisp and dark yellow, sieve out the sand, put into the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of chicken's gizzard lining and the mixed solution is 7: 1), and obtain the chicken's gizzard lining processed after drying; Pig's hoof is removed of impurities, cleaned and dried, put into the sand heated with high heat, stir-fried until the pig's hoof as a whole swells and is golden yellow, sieve out the sand and take out, be placed in the mixed solution of aloe juice and vinegar and quench (the mass ratio of vinegar to aloe juice in the mixed solution is 15: 1, and the mass ratio of pig's hoof and the mixed solution is 4: 1), and obtain the pig's hoof processed after drying;

[0055] S3, take dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof nail, Hericium erinaceus and fried malt, grind into Chinese medicine powder, pass through 100 mesh sieve for later use;

[0056] S4, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract;

[0057] S5. Mix the above-mentioned Chinese medicine powder and extract to prepare granules, thereby obtaining the Chinese medicine composition of this embodiment.

[0058] Test example

[0059] Chronic atrophic gastritis (CAG), the pathogenic factor of which is Helicobacter pylori (HP) infection, has a detection rate of up to 70-95%. In the treatment of CAG, if HP is killed, its effective rate can be increased and the recurrence rate can be reduced. This test case selected 100 CAG patients, all of whom were HP-positive patients, as the efficacy observation before and after treatment, and the summary is as follows:

[0060] 1. General data: 100 patients with HP-positive CAG (identified by TCM as liver-spleen disharmony, stomach disharmony, and long-term depression causing blood stasis and heat) were selected, including 52 males and 48 females, aged 36-71 years old. All patients were examined by gastroscopy and urea[ 14 C] The diagnosis is confirmed by breath test. The clinical symptoms are mostly epigastric pain involving the ribs, abdominal distension, belching, etc.

[0061] The diagnostic criteria were based on the relevant contents of Internal Medicine (Third Edition) edited by Liu Shisheng and Traditional Chinese Medicine Internal Medicine edited by Pan Tao and Dai Aiguo.

[0062] 2. Treatment method: During the treatment period, the patient stops taking all gastric drugs and takes the tablets prepared in Example 1, 6-8 tablets each time, twice a day, and one month is one course of treatment.

[0063] 3. Treatment effect

[0064] Efficacy evaluation criteria:

[0065] Markedly effective: After treatment, the score value is reduced by more than 70%, the clinical symptoms disappear completely or basically disappear, and gastroscopy and pathological histological examination show that the gastric mucosal lesions basically return to normal;

[0066] Effective: After treatment, the score value is reduced by 30-70%, the clinical symptoms are significantly alleviated, and gastroscopy and pathological histological examinations show that the gastric mucosal lesions are alleviated or the lesion range is reduced;

[0067] Ineffective: The treatment score did not decrease, the clinical symptoms did not improve significantly, and gastroscopy and pathological histological examinations showed no significant changes or aggravation of gastric mucosal lesions.

[0068] Clinical efficacy: 63 cases were markedly effective, 29 cases were effective, 8 cases were ineffective, and the total effective rate was 92%. The symptom incidence rates before and after treatment are shown in Table 1, where the incidence rate before treatment = number of cases before treatment / 100; the incidence rate after treatment = number of cases after treatment / number of cases before treatment.

[0069] Table 1

[0070]

[0071] HP negative conversion rate: Among 100 HP-positive patients, 91 turned negative after treatment, with a negative conversion rate of 91%.

[0072] The gastroscopic changes before and after treatment are shown in Table 2.

[0073] Table 2

[0074]

[0075]

[0076] Pathological histological changes: After treatment, the degree of atrophy of gastric mucosal glands was alleviated in 92 out of 100 patients; intestinal metaplasia and atypical hyperplasia were improved; pathological changes such as inflammatory cell infiltration were controlled or reversed.

[0077] Case 1: Patient Ding, female, 54 years old, retired employee. Due to long-term emotional distress and irregular diet, she suffered from upper abdominal pain involving the ribs, accompanied by bitter taste in the mouth, belching, poor appetite, and abdominal distension. The tongue was red with petechiae and ecchymoses, thin yellow fur, and deep and stringy pulse. She had been treated in a hospital for more than two years, with varying degrees of severity. Gastroscopy showed: chronic atrophic gastritis; pathological histological examination: atrophy of gastric mucosal glands and intestinal metaplasia, inflammatory cell infiltration; urea[ 14 C] Breath test: HP positive. TCM syndrome differentiation is stomach pain (liver and spleen disharmony, stomach disharmony, blood stasis and heat), treatment should be soothing the liver, strengthening the spleen and stomach, clearing away heat and removing blood stasis. Tablets of Example 1, 8 tablets each time, 2 times a day. After taking the medicine for 1 month, the clinical symptoms disappeared, and the gastroscopy was reviewed: from chronic atrophic gastritis to chronic superficial gastritis. Pathological review: gastric mucosal gland atrophy reversed, intestinal metaplasia disappeared, and inflammatory cell infiltration was alleviated. Re-examination of breath test: HP negative. Advise to continue taking the above medicine to consolidate the therapeutic effect.

[0078] Case 2: Patient Li, male, 65 years old, retired teacher. Due to depression and long-term social activities, he suffered from upper abdominal distension and pain, involving the ribs, accompanied by bitter taste in the mouth, belching, and poor appetite. The tongue was red, the veins under the tongue were purple and swollen, the fur was thin and yellow, and the pulse was deep and stringy. Gastroscopy showed: chronic atrophic gastritis; pathological examination: atrophy of gastric mucosal epithelium and glands, decreased number, intestinal metaplasia, inflammatory cell infiltration; urea [ 14 C] Breath test: HP positive. TCM syndrome differentiation is epigastric pain (liver and spleen disharmony, stomach disharmony, blood stasis and heat), treatment should be soothing the liver, strengthening the spleen and stomach, clearing away heat and removing blood stasis. Tablets of Example 1, 8 tablets each time, 2 times a day. After taking the medicine for 1 month, the clinical symptoms basically disappeared. Gastroscopy review, from chronic atrophic gastritis to chronic superficial gastritis. Pathological review: gastric mucosal gland atrophy reversed, intestinal metaplasia disappeared, inflammatory cell infiltration alleviated. Breath test review: HP negative. Advise to continue taking the above medicine to consolidate the therapeutic effect.

[0079] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents the selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present application.

Claims

1. A Chinese medicine composition for treating chronic atrophic gastritis, characterized in that: The ingredients include: dandelion, oldenlandia diffusa, atractylodes, poria, coix seed, amomum villosum, bergamot, tangerine peel, chicken gizzard lining, hawthorn, roasted malt, radish seed, pig's hoof, purple cabbage and Hericium erinaceus.

2. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 5-35 parts of dandelion, 5-35 parts of oldenlandia diffusa, 5-10 parts of atractylodes, 5-30 parts of tuckahoe, 5-30 parts of coix seed, 5-6 parts of amomum villosum, 5-10 parts of citrus hand, 5-10 parts of tangerine peel, 5-10 parts of chicken gizzard lining, 5-10 parts of hawthorn, 5-10 parts of roasted malt, 5-15 parts of radish seed, 5-10 parts of pig's hoof, 5-10 parts of purple cabbage and 5-10 parts of Hericium erinaceus.

3. A Chinese medicine composition for treating chronic atrophic gastritis according to claim 2, characterized in that: The invention comprises the following raw materials in parts by weight: 30 parts of dandelion, 30 parts of oldenlandia diffusa, 10 parts of atractylodes, 20 parts of tuckahoe, 30 parts of coix seeds, 6 parts of amomum, 10 parts of bergamot, 10 parts of tangerine peel, 10 parts of chicken gizzard lining, 10 parts of hawthorn, 10 parts of roasted malt, 10 parts of radish seeds, 6 parts of pig's hoof, 10 parts of purple cabbage and 10 parts of Hericium erinaceus.

4. A method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Grind dandelion, Amomum villosum, processed chicken gizzard lining, processed pig hoof, Hericium erinaceus and roasted malt into Chinese medicinal powder for later use; S2, washing and mixing Hedyotis diffusa, Atractylodes macrocephala, Poria cocos, Citrus citron, Coix seeds, orange peel, Hawthorn, Radish seeds and purple cabbage, and then extracting them by ethanol extraction to prepare an extract; S3. Mix the above-mentioned Chinese medicine powder and extract to make granules, pills, tablets or capsules.

5. The method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to claim 4, characterized in that: The prepared chicken's gizzard lining in step S1 is prepared by the following method: remove impurities from the chicken's gizzard lining, wash and dry in the shade, take sand and put it in a pot, heat it, then add the chicken's gizzard lining and stir-fry until the chicken's gizzard lining turns dark yellow, take it out, sieve out the sand, put it into a mixture of aloe juice and vinegar for immersion and quenching, and dry it to obtain the prepared chicken's gizzard lining.

6. The method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to claim 4, characterized in that: The prepared pig's hoof in step S1 is prepared by the following method: remove impurities from the pig's hoof, wash and dry it, put it into sand heated by high heat, fry it until the pig's hoof is swollen and golden yellow, sieve the sand out, immerse it in a mixture of aloe juice and vinegar, and dry it.

7. A method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to claim 5 or 6, characterized in that: The mass ratio of vinegar to aloe juice in the mixed solution is 15:

1.

8. The method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to claim 7, characterized in that: The mass ratio of the pig's hoof to the mixed liquid is (3-5):1; the mass ratio of the chicken's gizzard lining to the mixed liquid is (4-7):

1.

9. The method for preparing a Chinese medicine composition for treating chronic atrophic gastritis according to claim 4, characterized in that: The Chinese medicine powder in S1 is sieved through a 100-mesh sieve.

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