Permeation enhancing composition as well as preparation method and application thereof

Abstract

The invention discloses a permeation enhancing composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a penetration enhancing composition which comprises the following components in parts by weight: a component A and a component B. The component A comprises 1-5 parts by weight of Olivem 1000; the component B is prepared from the following components in parts by weight: 0.5 to 3 parts of Oliwax LC and 0.5 to 3 parts of Surfinesse Clean G; the total mass ratio of the component A to the component A and the component B is N, and N is larger than or equal to 0.4. In the actual experiment process, the inventor finds that when the Olivem 1000, the Oliwax LC and the Surfinesse Clease G are cooperatively used, the combination of the Olivem 1000, the Oliwax LC and the Surfinesse Clease G functionally forms multi-dimensional synergy of'emulsification + infiltration promotion + repair '.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, in particular to a penetration-enhancing composition and a preparation method and application thereof. Background Art

[0002] Human skin is the first biological barrier of the body. The unique "brick wall structure" of its stratum corneum makes it difficult for more than 90% of the active ingredients in cosmetics to achieve effective transdermal absorption. The current industry mainly uses four major technical systems: chemical penetration enhancement, nanocarriers, physical introduction and biological penetration enhancement to improve transdermal delivery efficiency, but each technical route has significant application bottlenecks: (1) Chemical penetration enhancement technology: Although traditional penetration enhancers (such as azone, dimethyl sulfoxide, etc.) can improve permeability by changing the lipid arrangement of the stratum corneum, clinical studies have shown that when the added concentration is too high or the continuous use time is too long, the probability of inducing contact dermatitis is significantly increased. Long-term use can destroy the balance of skin microecology, leading to abnormal fluctuations in epidermal pH and downregulation of barrier protein FLG gene expression. (2) Nanocarrier technology: Although nanoemulsions, liposomes and other carriers have been developed (the particle size is mostly distributed in 50-200nm), there are two major technical barriers: first, the stability of nanomaterials in cosmetic matrices is insufficient; second, nanoparticles that are too small can penetrate the epidermis into the dermis, posing a potential risk of bioaccumulation. (3) Physical penetration enhancement technology: Although equipment-dependent technologies such as ion introduction and microneedle can improve skin penetration, they are complex to operate, costly, and invasive, making it difficult to meet the convenience needs of daily skin care scenarios. (4) Biological penetration enhancement technology: Although biomimetic carriers developed based on endogenous skin substances such as ceramide and cholesterol have excellent biocompatibility, current technologies are difficult to balance the stability of amphiphilic structures: when the HLB value is controlled at 7-9, the phase transition temperature of the lipid bilayer will drop below 25°C, causing the carrier to disintegrate prematurely at room temperature; and the addition of stabilizers such as polysorbate will cause skin irritation risks.

[0003] In view of this, this application is filed. Summary of the invention

[0004] Based on this, the purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide a penetration-enhancing composition and a preparation method and application thereof.

[0005] To achieve the above-mentioned purpose, the first aspect of the present application provides a penetration-enhancing composition, comprising the following components in parts by weight: component A and component B; component A comprises 1-5 parts by weight of Olivem 1000; component B comprises: 0.5-3 parts by weight of Oliwax LC and 0.5-3 parts by weight of Surfinesse Cleanse G; the total mass ratio of component A to component A and component B is N, and N≥0.4.

[0006] The inventors found in the actual experimental process that when Olivem 1000, Oliwax LC and Surfinesse Cleanse G are used in conjunction, the combination of the three forms a multi-dimensional synergy of "emulsification + penetration promotion + repair" in terms of function. On the one hand, the combined use of the above three components can reduce the stratification of the system and improve the centrifugal stability through the superposition and complementarity of liquid crystal structures; Olivem 1000 is an olive-derived liquid crystal emulsifier that can form a liquid crystal layered structure similar to the structure of the skin's stratum corneum, and has excellent emulsification ability and stability; Surfinesse Cleanse G exhibits an emulsification effect with small droplets and dense and uniform droplets in the system; Oliwax LC, as an auxiliary emulsifier, can further improve the stability of the system by adjusting the liquid crystal arrangement. On the other hand, the combined use of the above three components can improve the delivery efficiency of active ingredients; the liquid crystal structure of Olivem 1000 is similar to the stratum corneum of the skin, which can promote the sustained release and penetration of active ingredients. Oliwax LC and Surfinesse Cleanse G, as auxiliary ingredients, can further improve the delivery efficiency of active ingredients by adjusting interfacial tension and liquid crystal arrangement. On the other hand, the combined use of the above three components can repair damaged skin barriers and further reduce the irritation response of sensitive skin. Olivem1000 repairs damaged skin barriers by reducing the release of inflammatory factors and enhancing cell vitality, and is combined with the stable emulsification system of Oliwax LC and Surfinesse Cleanse G to further repair damaged skin barriers.

[0007] As an embodiment of the present application, the component A includes 3-4 parts by weight of Olivem 1000; the component B includes 1-2 parts by weight of Oliwax LC and 1-2 parts by weight of Surfinesse Cleanse G.

[0008] As an implementation scheme of the present application, N satisfies 0.6≤N≤0.7.

[0009] The inventors found in the actual experimental process that when Olivem 1000, Oliwax LC and Surfinesse CleanseG are used in conjunction, the weight proportions of the three will further affect the emulsification, penetration and repair effects. When the weight proportions of the three are within the above range, while ensuring the stability of the system, the penetration and repair effects are better.

[0010] As an embodiment of the present application, the weight ratio of Oliwax LC to Surfinesse Cleanse G in component B is 1:1.

[0011] The inventors found in actual experiments that the weight ratio of Oliwax LC and Surfinesse Cleanse G in component B further affects the emulsification, penetration and repair effects. When the weight ratio of Oliwax LC and SurfinesseCleanse G in component B is 1:1, while ensuring the stability of the system, the penetration and repair effects are better.

[0012] As an embodiment of the present application, the penetration-enhancing composition further includes 1-3 parts by weight of ergothioneine; and / or, the penetration-enhancing composition further includes 1-3 parts by weight of acetyl hexapeptide-8.

[0013] The inventors found in the actual experimental process that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the penetration-promoting and repairing effects of the system are better.

[0014] As an embodiment of the present application, the penetration-enhancing composition further includes 1.5-2.5 parts by weight of ergothioneine; and / or, the penetration-enhancing composition further includes 1.5-2.5 parts by weight of acetyl hexapeptide-8.

[0015] The inventors found in the actual experimental process that the weight portions of ergothioneine and acetyl hexapeptide-8 in the penetration-promoting composition further affect the effects of penetration promotion and repair. Under the above-mentioned weight portion selection, the effects of penetration promotion and repair are better.

[0016] In one embodiment, the penetration enhancing composition comprises ergothioneine and acetyl hexapeptide-8.

[0017] As an embodiment of the present application, the weight ratio of ergothioneine to acetyl hexapeptide-8 is 1:1.

[0018] The inventors found in the actual experimental process that when the penetration-promoting composition contains both ergothioneine and acetyl hexapeptide-8, the penetration-promoting and repairing effects can be better reflected in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0019] In the second aspect of the present application, the present application provides use of the penetration-enhancing composition in the preparation of skin products.

[0020] In the third aspect of the present application, the present application provides a skin product, which comprises the penetration-enhancing composition.

[0021] As an embodiment of the present application, the dosage form of the skin product is a water solution, emulsion, cream, gel, mask or essence.

[0022] As an embodiment of the present application, the skin product includes the following components in percentage by mass: 1-5% of the penetration enhancing composition, 2-30% of the cosmetic base, and the balance of water; the cosmetic base includes at least one of a moisturizer, a thickener, a skin conditioner, an antioxidant, and an emollient.

[0023] In one embodiment, the present application provides a skin product comprising the following components in percentage by weight: 1-5% penetration enhancing composition, 1-10% moisturizer, 0.1-0.5% thickener, 0.05-1% skin conditioner, 0.5-1% antioxidant, 2-12% emollient, and the balance deionized water.

[0024] Exemplarily, the moisturizer includes at least one of glycerin, butylene glycol, low molecular weight sodium hyaluronate, and 1,2-hexanediol; the thickener includes at least one of xanthan gum, carbomer 980, high molecular weight cellulose, and polyacrylate cross-linked polymer-6; the skin conditioner includes at least one of trehalose, allantoin, and hyaluronic acid; the antioxidant includes at least one of tocopheryl acetate, parahydroxyacetophenone, and ascorbic acid; the emollient includes at least one of polydimethylsiloxane, avocado tree (BUTYROSPERMUM PARKII) fruit butter, caprylic / capric triglyceride, petrolatum, and stearyl alcohol.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows: when Olivem 1000, Oliwax LC and SurfinesseCleanse G are used in synergy, the combination of the three forms a multi-dimensional synergy of "emulsification + penetration promotion + repair" in terms of function. On the one hand, the combined use of the above three components can reduce the stratification of the system and improve the centrifugal stability through the superposition and complementarity of the liquid crystal structure; Olivem 1000 is an olive-derived liquid crystal emulsifier, which can form a liquid crystal layered structure similar to the structure of the skin stratum corneum, and has excellent emulsification ability and stability; Surfinesse Cleanse G exhibits an emulsification effect with small droplets, dense and uniform in the system; Oliwax LC, as an auxiliary emulsifier, can further improve the stability of the system by adjusting the liquid crystal arrangement. On the other hand, the combined use of the above three components can improve the delivery efficiency of active ingredients; the liquid crystal structure of Olivem 1000 is similar to the stratum corneum of the skin, which can promote the sustained release and penetration of active ingredients. Oliwax LC and Surfinesse Cleanse G, as auxiliary ingredients, can further improve the delivery efficiency of active ingredients by adjusting interfacial tension and liquid crystal arrangement. On the other hand, the combined use of the above three components can repair damaged skin barriers and further reduce the irritation response of sensitive skin. Olivem 1000 repairs damaged skin barriers by reducing the release of inflammatory factors and enhancing cell vitality, and is combined with the stable emulsification system of Oliwax LC and Surfinesse Cleanse G to further repair damaged skin barriers. DETAILED DESCRIPTION

[0026] In order to better illustrate the purpose, technical scheme and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. Its purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Unless otherwise specified, the experimental reagents and instruments designed for the implementation and comparative examples of the present invention are all commonly used ordinary reagents and instruments, which can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are conventional methods unless otherwise specified; and unless otherwise specified, the raw materials used in parallel experiments are the same batch of raw materials.

[0027] The raw materials used in the present invention are described as follows, but are not limited to the following raw materials:

[0028] Olivem 1000: purchased from HALLSTAR BEAUTY, INCI: cetearyl olivate, sorbitan olivate;

[0029] Oliwax LC: available from HALLSTAR BEAUTY, INCI: cetyl palmitate, sorbitan palmitate and sorbitan olivate;

[0030] Surfinesse Cleanse G: HALLSTAR BEAUTY, INCI: Polyglyceryl-4 Oleate (and) Ethyl Olivate;

[0031] Ergothioneine, acetyl hexapeptide-8, etc. are all conventional commercially available products.

[0032] Olivem 2020G: purchased from HALLSTAR BEAUTY, INCI: Ethylhexyl olivetate, sodium acrylates copolymer, polyglyceryl-4 oleate;

[0033] Olivem 700: purchased from HALLSTAR BEAUTY, INCI: PEG-4 olive oil ester;

[0034] Montanov 202: Seppic, France, INCI: Arachidyl alcohol, Behenyl alcohol, Arachidyl glucoside.

[0035] Examples and Comparative Examples

[0036] The present application provides a penetration-enhancing composition. The components and weight portions of the penetration-enhancing composition of the embodiment and comparative example are selected as shown in Tables 1-2 below. The preparation method of the penetration-enhancing composition is: all the components are mixed evenly to obtain the composition. When preparing the comparative example composition, if there is no relevant component, then it is not added. If there are other components, they are also added together and mixed evenly.

[0037] Table 1

[0038]

[0039] Table 2

[0040]

[0041]

[0042] Application Examples

[0043] Application Examples 1-13 and Comparative Application Examples 1-7 of the present invention provide an emulsion, the components (mass percentage) of the emulsion are shown in Table 3; wherein the penetration-enhancing compositions in Application Examples 1-12 are the penetration-enhancing compositions prepared in Examples 1-12, and the penetration-enhancing compositions in Comparative Application Examples 1-7 are the penetration-enhancing compositions prepared in Comparative Examples 1-7; for example, the penetration-enhancing composition used in Application Example 1 is the penetration-enhancing composition prepared in Example 1, the penetration-enhancing composition used in Application Example 2 is the penetration-enhancing composition prepared in Example 2, the penetration-enhancing composition used in Comparative Application Example 1 is the penetration-enhancing composition prepared in Comparative Example 1, and the like. The penetration-enhancing composition used in Application Example 13 is the penetration-enhancing composition prepared in Example 6.

[0044] Table 3

[0045]

[0046]

[0047] The preparation method of the emulsion comprises the following steps:

[0048] (1) Component A and water are mixed and stirred, heated to 80° C., homogenized at a speed of 1200 rpm for 5 minutes, and kept warm for later use to obtain prefabricated component A;

[0049] (2) Mixing component B, heating to 80° C., homogenizing at 1200 rpm for 5 min, and keeping warm for later use to obtain prefabricated component B;

[0050] (3) mixing the C components and heating them to 60° C. to melt them to obtain a prefabricated C component;

[0051] (4) The preformed component A is heated to 80°C, and the preformed component B is added at a rotation speed of 300 rpm, and stirred and mixed. Then, the temperature is lowered to 60°C, and the preformed component C is added at a rotation speed of 300 rpm, and stirred and mixed. Then, the temperature is lowered, and the material is discharged to obtain an emulsion.

[0052] Performance Test-1Stability Test

[0053] The emulsions prepared in the application examples and comparative application examples were subjected to stability tests. The heat resistance test was to stand at 48°C for three months and observe its appearance, color and odor; the cold resistance test was to stand at -18°C for three months and observe its appearance, color and odor; the normal temperature test was to stand at 25°C for three months and observe its appearance, color and odor; the hot and cold cycle test was to store at 45°C, normal temperature and -18°C for 24 hours each, cycle 10 times, and observe its appearance, color and odor. The test results are shown in Table 4.

[0054] Table 4

[0055]

[0056]

[0057] It can be seen from the above table that the emulsions prepared in the application examples of the present invention and the comparative application examples have excellent stability.

[0058] Performance Test-2 Penetration Test

[0059] Taking retinol as the target active ingredient, the compositions prepared in Examples 1-12 and Comparative Examples 1-7 were diluted with deionized water to a mass percentage of 3%, and then prepared with retinol at a ratio of 95:5 to prepare the test substance, so as to examine the penetration-enhancing effect of the penetration-enhancing compositions of the Examples and Comparative Examples.

[0060] The pigskin-Franzcell permeation diffusion cell test was used (the instrument was a TK-type transdermal absorption tester, and the instrument operation method can be referred to), with reference to the national standard GBT27818-2011.

[0061] The specific method is as follows: remove hair and subcutaneous tissue from fresh pig back skin, clean it, dry it and cut it into suitable sizes for standby use. The pig back skin comes from a slaughterhouse. Fix the pig back skin between the supply chamber and the receiving chamber of the TK transdermal absorption tester. The receiving liquid is an isotonic PBS buffer solution. The test liquid is the composition of the embodiment and the comparative example. Five groups of samples are tested in parallel, and the average value is taken. The transdermal test is carried out in a 37°C circulating water bath. Take 0.5mL of sample at 4h and 12h after the start of the test, and add 0.5mL of PBS after sampling. The sample is filtered through a 0.22μm filter membrane and used as a test sample. The diffusion percentage of retinol in the 4h and 12h samples is detected and calculated respectively.

[0062] Among them, the content of retinol was tested using the determination method of "Guangdong Cosmetics Association Group Standard T / GDCA 005-2021 Retinol, Retinol Acetate, Retinol Palmitate, and Hydroxypinacolone Retinoate in Cosmetics".

[0063] The test results are shown in Table 5.

[0064] Table 5

[0065] Case 4h Retinol diffusion percentage / % 12h Retinol diffusion percentage / % Example 1 22.78 32.19 Example 2 22.47 32.00 Example 3 20.05 30.21 Example 4 20.56 30.38 Example 5 20.64 30.55 Example 6 26.65 36.76 Example 7 24.12 33.82 Example 8 27.37 38.21 Example 9 27.45 38.19 Example 10 30.85 42.78 Embodiment 11 29.35 41.05 Example 12 29.32 41.28 Comparative Example 1 5.33 5.65 Comparative Example 2 7.53 8.65 Comparative Example 3 8.42 8.72 Comparative Example 4 5.36 5.84 Comparative Example 5 5.33 5.81 Comparative Example 6 8.21 8.96 Comparative Example 7 7.83 8.20

[0066] It can be seen from the above table that the penetration-enhancing composition prepared in the examples of the present invention has an excellent penetration-enhancing effect and can effectively promote the penetration of active ingredients.

[0067] From the comparison of Examples 1-7, it can be seen that when Olivem 1000, Oliwax LC and SurfinesseCleanse G are used in conjunction in the penetration enhancing composition, the weight parts of the three will affect the final penetration enhancing effect. When the component A includes the following ingredients in weight parts: Olivem 1000 3-4 parts; the component B includes the following ingredients in weight parts: Oliwax LC 1-2 parts and Surfinesse Cleanse G 1-2 parts, the penetration enhancing effect is better.

[0068] From the comparison of Examples 1-7, it can be seen that when the ratio of the weight of component A to the total weight of component A and component B in the penetration-enhancing composition is ≥0.6, the penetration-enhancing effect is better.

[0069] From the comparison of Examples 1-7, it can be seen that when the weight ratio of Oliwax LC to SurfinesseCleanse G in component B of the penetration enhancing composition is 1:1, the penetration enhancing effect is better.

[0070] By comparing Example 6 and Examples 8-12, it can be seen that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the penetration-promoting effect of the system is better.

[0071] By comparing Examples 8-9 and Examples 10-12, it can be seen that when the penetration-enhancing composition contains both ergothioneine and acetyl hexapeptide-8, the penetration-enhancing effect can be better reflected in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0072] Compared with Example 6, Comparative Examples 1-3 lack one of Olivem 1000, Oliwax LC and Surfinesse Cleanse G. As a result, it is found that the penetration-enhancing effect is extremely poor. In the penetration-enhancing composition of the present invention, Olivem 1000, Oliwax LC and Surfinesse Cleanse G are indispensable. Compared with Example 6, Comparative Examples 4-6 use other raw materials to replace one of Olivem 1000, Oliwax LC and Surfinesse Cleanse G. As a result, it is found that the penetration-enhancing effect is extremely poor. In the penetration-enhancing composition of the present invention, Olivem 1000, Oliwax LC and Surfinesse Cleanse G are irreplaceable. Compared with Example 6, Comparative Example 7 has a total mass ratio of component A to component A and component B <0.4. As a result, it is found that the penetration-enhancing effect is extremely poor. The weight portions of Olivem 1000, Oliwax LC and Surfinesse Cleanse G in the penetration-enhancing composition of the present invention need to be within a specific range to achieve a good penetration-enhancing effect.

[0073] Performance Test-3

[0074] The effect examples of the present invention verify the safety performance of the products prepared by application examples 1-13 and comparative application examples 1-7.

[0075] 30 volunteers were recruited, 15 males and 15 females, aged 20-50 years old. The closed patch test method was used. An equal amount (0.020mL-0.025mL) of the test sample was placed in a specific patch tester, which was applied to the volunteer's arm with a low-allergenic tape, and gently pressed to evenly apply it on the skin for 24 hours. The blank control group was distilled water. After 24 hours, the patch tester was removed, and the skin reaction was observed after 0.5h, 24h, and 48h, and the results were recorded. The level of adverse reactions to the skin is shown in Table 6 below.

[0076] Table 6

[0077]

[0078]

[0079] After testing, the emulsions provided in the application examples of the present invention and the comparative application examples all showed negative reactions after human patch tests, and they are safe and non-irritating to human skin.

[0080] Performance Test-4

[0081] The effect examples of the present invention verify the repair performance of the products prepared by the application examples and comparative application examples.

[0082] The test process is as follows: Volunteers aged 18-45 are selected. No skin care products are applied on the day of the visit. After washing their faces, the subjects sit quietly in a constant temperature and humidity room at 21±1℃ and 50±10% for 30 minutes. TM Hex (Courage+Khazaka) tests the initial facial TEWL value. The subjects were randomly divided into 20 groups, 5 in each group, and the application example and comparison application example products were randomly used on the whole face. TEWL tests and Visia-7 photography were performed on the 7th and 14th days, and the TEWL improvement of each volunteer on the 0th, 7th, and 14th days was analyzed. The improvement is represented by the improvement rate of each value, and the calculation method is as follows:

[0083] Improvement rate relative to initial value = (X 使用前 -X 使用后 ) / X 使用前 ×100%;

[0084] The transepidermal water loss TEWL value is a commonly used indicator reflecting the barrier function of the stratum corneum. The lower the TEWL value, the better the skin barrier function and the better the repair effect of the product.

[0085] The test results are shown in Table 7;

[0086] Table 7

[0087]

[0088]

[0089] It can be seen from the above table that the penetration-enhancing composition prepared in the embodiment of the present invention, when applied to the emulsion formula, can repair the damaged skin barrier and further reduce the irritation reaction of sensitive skin.

[0090] From the comparison of Examples 1-7, it can be seen that when Olivem 1000, Oliwax LC and SurfinesseCleanse G are used in conjunction in the penetration enhancing composition, the weight parts of the three will affect the final repair effect. When the component A includes the following ingredients in weight parts: Olivem 1000 3-4 parts; the component B includes the following ingredients in weight parts: Oliwax LC 1-2 parts and Surfinesse Cleanse G 1-2 parts, the repair effect is better.

[0091] From the comparison of Examples 1-7, it can be seen that when the ratio of the weight of component A to the total weight of component A and component B in the penetration enhancing composition is ≥0.6, the repair effect is better.

[0092] From the comparison of Examples 1-7, it can be seen that when the weight ratio of Oliwax LC to SurfinesseCleanse G in component B of the penetration enhancing composition is 1:1, the repairing effect is better.

[0093] From the comparison of Example 6 and Examples 8-12, it can be seen that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the repair effect of the system is better.

[0094] By comparing Examples 8-9 and Examples 10-12, it can be seen that when the penetration-enhancing composition contains both ergothioneine and acetyl hexapeptide-8, the repair effect can be better reflected in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0095] Compared with Example 6, Comparative Examples 1-3 lack one of Olivem 1000, Oliwax LC and Surfinesse Cleanse G. As a result, it is found that the repair effect is extremely poor. Olivem 1000, Oliwax LC and Surfinesse Cleanse G are indispensable in the penetration-enhancing composition of the present invention. Compared with Example 6, Comparative Examples 4-6 use other raw materials to replace one of Olivem 1000, Oliwax LC and Surfinesse Cleanse G. As a result, it is found that the repair effect is extremely poor. Olivem 1000, Oliwax LC and Surfinesse Cleanse G in the penetration-enhancing composition of the present invention cannot be replaced. Compared with Example 6, Comparative Example 7 has a total mass ratio of component A to component A and component B <0.4. As a result, it is found that the penetration-enhancing effect is extremely poor. The weight parts of Olivem 1000, Oliwax LC and Surfinesse Cleanse G in the penetration-enhancing composition of the present invention need to be in a specific range to achieve a good repair effect.

[0096] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A penetration-enhancing composition, characterized in that The invention comprises the following components in parts by weight: component A and component B; The component A comprises 1-5 parts by weight of Olivem 1000; The component B comprises: 0.5-3 parts by weight of Oliwax LC and 0.5-3 parts by weight of Surfinesse Cleanse G; The total mass ratio of component A to component A and component B is N, and N≥0.

4.

2. The penetration-enhancing composition according to claim 1, wherein The component A comprises 3-4 parts by weight of Olivem 1000; The component B includes 1-2 parts by weight of Oliwax LC and 1-2 parts by weight of Surfinesse Cleanse G.

3. The penetration-enhancing composition according to claim 1, wherein The N satisfies 0.6≤N≤0.

7.

4. The penetration-enhancing composition according to claim 1, wherein The weight ratio of Oliwax LC to SurfinesseCleanse G in component B is 1:

1.

5. The penetration-enhancing composition according to claim 1, wherein Also comprising 1-3 parts by weight of ergothioneine; And / or, the penetration enhancing composition further comprises 1-3 parts by weight of acetyl hexapeptide-8.

6. The penetration-enhancing composition according to claim 5, wherein Also comprising 1.5-2.5 parts by weight of ergothioneine; And / or, the penetration enhancing composition further comprises 1.5-2.5 parts by weight of acetyl hexapeptide-8.

7. The penetration-enhancing composition according to claim 5 or 6, wherein The weight ratio of ergothioneine to acetyl hexapeptide-8 is 1:

1.

8. Use of the penetration-enhancing composition according to any one of claims 1 to 7 in the preparation of skin products.

9. A skin care product, characterized in that: The skin product comprises the penetration-enhancing composition according to any one of claims 1 to 7.

10. The skin care product according to claim 9, wherein: The skin care product comprises the following components in percentage by weight: 1-5% of the penetration-enhancing composition according to any one of claims 1 to 7, 2-30% of a cosmetic base, and the balance being water; the cosmetic base comprising at least one of a moisturizer, a thickener, a skin conditioner, an antioxidant, and an emollient.

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