An ion cloud control method, device, medium and computer device

Abstract

The application provides an ion cloud control method, device, medium and computer equipment, comprising: receiving an induced electric signal generated on a first electrode; performing filtering processing on the induced electric signal; generating an ion cloud control signal based on the filtered induced electric signal; applying the ion cloud control signal on a second electrode to adjust the motion time of an ion cloud in a quadrupole rod system or a multi-pole rod system; by using the method of the application, the flight time of the ion cloud in the quadrupole rod can be controlled, the processed pulse signal is amplified and fed back to the control circuit of the multi-pole rod outlet electrode, and the signal on the second electrode is used to generate an electric field to affect the flight speed of the ions in the quadrupole rod system, so that the flight time of each ion is controlled to be as close to the same length as possible, the number of distinguishable single particles or single cells per unit time is increased while the ion motion is more accurately controlled, and the throughput of single particle or single cell analysis is greatly improved.

Description

Technical Field

[0001] This invention relates to the field of particulate matter analysis technology, and more specifically, to an ion cloud control method, apparatus, medium, and computer equipment. Background Technology

[0002] This invention relates to the fields of analytical chemistry, mass spectrometry, and instrument control, specifically to ion cloud dynamic control and interference suppression techniques in inductively coupled plasma mass spectrometry (ICP-MS). This invention also relates to improving the performance of ICP-MS in rapid transient signal analysis, single-particle / single-cell detection, and coupling with other separation techniques.

[0003] Inductively coupled plasma mass spectrometry (ICP-MS) is a highly sensitive elemental analysis technique, but it faces challenges due to interfering elements and matrix effects in complex samples. Collision / reaction cell techniques and high-resolution mass spectrometry can partially address interference issues, but often at the cost of reduced sensitivity or increased complexity. Existing techniques, such as multi-collector ICP-MS (MC-ICP-MS), have made significant progress in high-precision isotope analysis, but still have limitations in processing fast transient signals. While existing techniques may suppress low-concentration signal interference through more complex structural designs, electrical system designs, and data processing algorithms, they have not yet solved the problem of suppressing the inherent background argon ion peak and its adduct peaks in ICP-MS.

[0004] Furthermore, with the increasing demand for coupling ICP-MS with separation techniques such as chromatography and electrophoresis, especially for transient ion clusters such as single particles and single cells, the requirement for rapid and precise control of ion transport is becoming more urgent. Existing technologies, due to their inability to adjust the duration of ion clouds, limit the number of single particles or single cells that can be resolved and analyzed per unit time, significantly reducing analytical throughput. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of this invention is to provide an ion cloud control method, device, medium and computer equipment to overcome the disadvantages of the existing technology, which is that the inability to adjust the flight time of the ion cloud results in a limited number of single particles or single cells that can be resolved and analyzed per unit time, and a reduction in analytical throughput.

[0006] The above-mentioned technical objective of the present invention is achieved through the following technical solution: an ion cloud control method applied to a bar mass analyzer; the bar mass analyzer includes: a quadrupole system or a multipole system, a first electrode, and a second electrode; the first electrode is disposed at the input end of the quadrupole system or the multipole system; the second electrode is disposed at the output end of the quadrupole system or the multipole system;

[0007] The ion cloud control method includes:

[0008] In response to the input of the ion cloud, the induced electrical signal generated on the first electrode is received;

[0009] The induced electrical signal is filtered.

[0010] Based on the filtered induced electrical signal, an ion cloud control signal is generated.

[0011] The ion cloud control signal is applied to the second electrode to adjust the motion time of the ion cloud in the quadrupole system or the multipole system.

[0012] In one embodiment, the filtering process of the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0013] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out the portion of the induced electrical signal above 2kHz to obtain a filtered induced electrical signal.

[0014] In one embodiment, the ion cloud control signal is specifically a square wave.

[0015] In one embodiment, the ion cloud control signal is specifically a square wave signal with a linearly varying rising edge.

[0016] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0017]

[0018] Where t1 represents the start time of the rising edge of the square wave signal; t2 represents the end time of the rising edge of the square wave signal; v2 represents the pulse amplitude of the basic square wave; and v1 represents the pulse amplitude of the basic exponential function.

[0019] In one embodiment, the ion cloud is composed of a plurality of ions;

[0020] The motion time is specifically defined as follows: the motion time of each ion in the ion cloud is between 47 μs and 53 μs.

[0021] An ion cloud control device, comprising:

[0022] A receiving unit is used to receive an induced electrical signal generated on the first electrode in response to the input of the ion cloud;

[0023] A filtering unit is used to filter the induced electrical signal;

[0024] The generation unit is used to generate an ion cloud control signal based on the filtered induced electrical signal;

[0025] An adjustment unit is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0026] A computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the method described above.

[0027] A computer device includes a memory and a processor, the memory storing a computer program, and the processor executing the computer program to implement the steps of the method described above.

[0028] In summary, the present invention has the following beneficial effects: an ion cloud control method includes: receiving an induced electrical signal generated on a first electrode in response to an input ion cloud; filtering the induced electrical signal; generating an ion cloud control signal based on the filtered induced electrical signal; applying the ion cloud control signal to a second electrode to adjust the flight time of the ion cloud in the quadrupole system or the multipole system; by using the method of the present invention, the flight time of the ion cloud in the quadrupole can be controlled, the processed pulse signal can be amplified and fed back to the control circuit of the multipole outlet electrode, and the electric field generated by the signal on the second electrode can be used to affect the flight speed of the ions in the quadrupole system, thereby making the flight time of each ion as close to the same length as possible. While controlling the ion movement more precisely, the number of single particles or single cells that can be resolved and analyzed per unit time is increased, thereby significantly improving the throughput of single particle or single cell analysis. Attached Figure Description

[0029] Figure 1 This is a flowchart of an ion cloud control method according to the present invention;

[0030] Figure 2 This is a structural diagram of the ion cloud control device in an embodiment of the present invention;

[0031] Figure 3 This is an internal structural diagram of the computer device in an embodiment of the present invention;

[0032] Figure 4 This is a structural diagram of the quadrupole system and electrode assembly in an embodiment of the present invention;

[0033] Figure 5 This is a schematic diagram of the voltage change curve in an embodiment of the present invention;

[0034] In the figure, 1 is the receiving unit; 2 is the filtering unit; 3 is the generating unit; 4 is the adjustment unit; 101 is the ion source; 102 is the ion cloud; 400 is the quadrupole system; 401 is the inlet electrode; 402 is the quadrupole; and 403 is the outlet electrode. Detailed Implementation

[0035] To make the objectives, features, and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Several embodiments of the present invention are shown in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein.

[0036] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances. The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" or "second" may explicitly or implicitly include one or more of that feature.

[0037] In this invention, unless otherwise expressly specified and limited, "above" or "below" a second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of a second feature includes the first feature being directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" of a second feature includes the first feature being directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature. The terms "vertical," "horizontal," "left," "right," "above," "below," and similar expressions are for illustrative purposes only and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed or operated in a specific orientation, and therefore should not be construed as limiting the invention.

[0038] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. To facilitate understanding of the embodiments, the relevant technology will first be explained. Quadrupole mass spectrometry manipulates the movement of ions by applying an alternating electric field. Only ions meeting a specific mass-to-charge ratio (m / z) range can pass through the quadrupole and reach the detector. Ions of other masses are deflected or become unstable and are thus excluded. This selective ion transport mechanism can achieve high resolution. By precisely adjusting the frequency of the alternating electric field, it is possible to ensure that ions with different mass-to-charge ratios pass through the quadrupole within a set time period. This method of controlling ion flight time can process multiple ion groups simultaneously and ensure that each ion group passes through the detector at a different time window. In single-particle or single-cell analysis, it is often necessary to analyze very small sample amounts with low instantaneous signal intensity. Therefore, precise control of flight time enables rapid analysis of these trace samples, reducing sample loss. Quadrupole mass spectrometry can also achieve simultaneous analysis of ions of multiple masses through flight time optimization, which greatly increases the number of ions that can be processed in a single run. High-throughput analysis requires processing large numbers of samples in a short time, while performing detailed analysis on each sample. By controlling the ion flight time, quadrupoles can analyze multiple ion signals per unit time, reducing the time required for a single analysis. However, when dealing with a large number of ions, simply controlling the ion flight time using a quadrupole is insufficient to meet the high-throughput requirements of rapid, instantaneous signal analysis.

[0039] Example 1

[0040] To address the above problems, this invention provides an ion cloud control method, such as... Figure 1 As shown, this is applied to a bar-type mass analyzer; the bar-type mass analyzer includes: a quadrupole system or a multipole system, a first electrode, and a second electrode; the first electrode is disposed at the input end of the quadrupole system or the multipole system; the second electrode is disposed at the output end of the quadrupole system or the multipole system;

[0041] The ion cloud control method includes:

[0042] S1. In response to the input of the ion cloud, receive the induced electrical signal generated on the first electrode;

[0043] S2. Filter the induced electrical signal;

[0044] S3. Based on the filtered induced electrical signal, generate the ion cloud control signal;

[0045] S4. Apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0046] In practical applications, such as Figure 4 As shown, a first electrode needs to be set at the input of the quadrupole system. When the ion cloud enters the quadrupole system, an induced electrical signal is generated on the first electrode. The intensity of the induced electrical signal is greater when the number of ions passing through is large, and weaker when the number of ions passing through is small. Therefore, by receiving the induced electrical signal generated on the first electrode, the intensity and time distribution of the ion cloud can be reflected. Due to the inherent time length of the ion cloud in ICP-MS (Inductively Coupled Plasma Mass Spectrometry), the frequency of the generated pulse signal will not exceed 2kHz. Therefore, other common-mode or conducted high-frequency interference must be filtered out. Then, the signal strength is enhanced by an amplification circuit to improve the accuracy of subsequent processing. The control device generates corresponding control signals based on the signal control. First, the analog signal peak shape is identified by the signal acquisition system, and the time length information is analyzed by a fast peak-finding algorithm, such as the 3-point peak-finding algorithm. By using the time length information, a voltage pulse peak with an adjustable rise time can be preset. This voltage pulse peak is then applied to the second electrode. After the voltage pulse peak is applied, the electric field generated by the second electrode can be used to control the flight velocity of the ion cloud in the quadrupole system, thereby maintaining the ion cloud's flight velocity as close to the same time length as possible. By controlling the ion cloud's flight velocity, the number of ions that can be processed in a single run is increased, improving the throughput of single-particle or single-cell analysis in the quadrupole system. This patented method is particularly outstanding in rapid transient signal analysis, meeting the needs of high-throughput analysis.

[0047] In one embodiment, the filtering process of the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0048] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out the portion of the induced electrical signal above 2kHz to obtain a filtered induced electrical signal.

[0049] In practical applications, in ICP-MS (Inductively Coupled Plasma Mass Spectrometry), the sample is atomized and ionized by plasma, generating an "ion cloud" composed of ions. The process of these ions residing in the plasma and transporting to the detector has a certain time limit, called the "intrinsic time length." This time length is determined by the plasma source, the sample atomization process, the ionization efficiency, and the speed at which the ions pass through the mass spectrometer. Due to the inherent delay and physical limitations in the generation and transport of the ion cloud, the frequency of the generated signal (i.e., the ion pulse signal) is not very high, typically below 2 kHz. This means that a maximum of 2000 ion signal peaks can be detected per second. Although the pulse signal generated by the ion cloud has a low frequency, other high-frequency noise or interference signals also exist in the ICP-MS system, including common-mode interference and conducted interference. Common-mode interference is an electrical interference, usually caused by the power supply or external circuitry of the system. The interference signal may appear synchronously in different parts of the system, affecting the entire circuit. Conducted interference is a high-frequency interference conducted through wires or circuits, usually originating from the power supply, motor, or other electrical equipment, affecting the instrument's measurements. The frequencies of these interferences are usually much higher than 2 kHz, even reaching tens of kilohertz or higher. Therefore, although the frequency of the ion cloud signal will not exceed 2kHz, high-frequency common-mode or conducted interference may still affect the measurement accuracy, and these interferences need to be filtered out.

[0050] In one embodiment, the ion cloud control signal is specifically a square wave.

[0051] In practical applications, the explicit on / off state of a square wave signal allows for precise control of the ion cloud's flight time. In a quadrupole system, adjusting the frequency and duty cycle of the square wave signal accurately modulates the ion cloud's flight time, enabling the system to better adapt to different ion characteristics and thus improve analytical accuracy and sensitivity. The modulation capability of the square wave signal allows for dynamic voltage control, including square wave generation, modulation, and pulse width adjustment. This enhances the system's dynamic control capabilities, allowing for flexible adjustments under varying operating conditions to meet the demands of rapid, instantaneous signal analysis.

[0052] In one embodiment, the ion cloud control signal is specifically a square wave signal with a linearly varying rising edge.

[0053] In practical applications, the sharp rising edge of a square wave generates strong electromagnetic interference (EMI). Replacing the rising edge with a linear rise can significantly reduce EMI because the linear transition of the signal is smoother, reducing the generation of high-frequency noise. The abrupt transition of a square wave can lead to switching noise; a linear rise makes the switching process smoother, thereby reducing the amplitude of noise and improving the signal quality and stability of the system. A linear rising edge makes the signal transition smoother, avoiding the instability caused by abrupt changes. Furthermore, a smooth transition helps reduce overshoot and ringing in analog and digital circuits, improving signal reliability and consistency. Signals with linear rising edges are more compatible with other circuits and systems, reducing sensitivity to high-frequency interference and improving system adaptability and stability.

[0054] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0055]

[0056] Where t1 represents the start time of the rising edge of the square wave signal; t2 represents the end time of the rising edge of the square wave signal; v2 represents the pulse amplitude of the basic square wave; and v1 represents the pulse amplitude of the basic exponential function.

[0057] In practical applications, particulate matter (the analyte) is ionized by laser at the center of the extraction region. The resulting positive and negative ions are then accelerated in opposite directions in the acceleration region. Ions of different masses are accelerated to different velocities under the influence of the electric field. After acceleration, they are detected by two mass analyzers. Therefore, the charge-to-mass ratio of the ions can be calculated based on their time of flight. During the ionization of the analyte, an explosion often occurs, resulting in both positive and negative ions having relatively large initial velocities. Ions of the same mass often have different velocities, thus affecting the resolution of the online aerosol mass spectrometer. A prior Chinese patent application (application number: CN201810149729.3) proposed a method to improve mass spectrometry resolution by changing the voltage parameters on the extraction electrode, such as... Figure 5As shown, changing the voltage parameter of the extraction region from a traditional DC voltage to a pulse voltage can effectively reduce the impact of the initial velocity of the analyte on the detection accuracy. Specifically, the DC voltage on the extraction electrode is modified to a pulse voltage. The low-level duration of the pulse voltage is the waiting time after the particle ionizes. This waiting time means waiting for the kinetic energy generated by the ions after the explosion to be completely consumed, allowing the movement of ions of different masses to stabilize. Then, the pulse voltage is adjusted to a high level, enabling the ions in the extraction region to be drawn into the acceleration region by the electric field of the extraction region when their motion states are similar. This ensures that ions of the same mass reach the detector in approximately the same time after entering the acceleration region, effectively improving the resolution of the mass spectrometer. This application also discloses using the following incremental extraction electrode voltage adjustment function to calculate the target voltage value that continuously varies within a preset ion flight time range:

[0058]

[0059] Where V represents the target voltage value, V1 is the pulse amplitude of the square wave function, V2(t) represents the exponential function, t represents the variable of ion flight time, t1 represents the waiting time after laser ionization, t2 represents the rise time of the exponential pulse, t3 represents the time after the pulse stabilizes, and v2 represents the pulse amplitude of the exponential function. Therefore, based on this patent, the rising edge of the square wave signal used to control the ion cloud in this application can also be adjusted based on this control signal. That is, the rising edge of the square wave signal is adjusted according to the following equation:

[0060]

[0061] Where t1 represents the start time of the rising edge of the square wave signal; t2 represents the end time of the rising edge of the square wave signal; v2 represents the pulse amplitude of the basic square wave; and v1 represents the pulse amplitude of the basic exponential function.

[0062] In one embodiment, the ion cloud is composed of a number of ions; the motion time is specifically: the motion time of each ion in the ion cloud is between 47 μs and 53 μs.

[0063] In one embodiment, the power-up method of the quadrupole radio frequency system conforms to the following equation:

[0064]

[0065] Where U represents DC voltage; V represents the amplitude of the main AC voltage; ω represents the angular frequency of the main AC voltage; V aux Indicates the amplitude of the auxiliary AC voltage; ω aux It is the angular frequency of the auxiliary AC voltage.

[0066] The relationship between the auxiliary angular frequency and the main frequency satisfies:

[0067] ω auxt =β×ω;

[0068] β is a coefficient that satisfies the following equation:

[0069]

[0070] Here, 'a' represents a stability parameter related to the DC voltage in the quadrupole system, used to describe the stability range of ions in the quadrupole electric field; in the stability plot of quadrupole mass spectrometry, parameter 'a' determines the effect of the DC electric field on the ions. According to the quadrupole equation, parameter 'a' is usually proportional to the DC voltage U applied to the quadrupole. Parameter 'q' is usually a stability parameter related to the AC voltage in the quadrupole system, used to describe the stability range of ions in an AC electric field (radio frequency field). Parameter 'q' is usually related to the AC voltage V applied to the quadrupole and the AC frequency ω. The value of parameter 'q' determines the stability of ions of different masses in the electric field and their ability to pass through the quadrupole.

[0071] Example 2

[0072] Please see Figure 2 An ion cloud control device, the ion cloud control device comprising:

[0073] The receiving unit 1 is used to receive the induced electrical signal generated on the first electrode in response to the input of the ion cloud;

[0074] Filtering unit 2 is used to filter the induced electrical signal;

[0075] Generation unit 3 is used to generate ion cloud control signals based on the filtered induced electrical signals;

[0076] The adjustment unit 4 is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0077] Specific limitations regarding the ion cloud control device can be found in the limitations of the ion cloud control method described above, and will not be repeated here. Each module in the aforementioned ion cloud control device can be implemented entirely or partially through software, hardware, or a combination thereof. These modules can be embedded in or independent of the processor in a computer device in hardware form, or stored in the memory of a computer device in software form, so that the processor can call and execute the operations corresponding to each module.

[0078] Those skilled in the art will understand that Figure 2The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the present application. Specific ion cloud control devices may include more or fewer components than those shown in the figures, or may combine certain components, or may have different component arrangements.

[0079] Example 3

[0080] A computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the ion cloud control method as described in Example 1.

[0081] Example 4

[0082] In one embodiment, a computer device is provided, which may be a server, and its internal structure diagram may be as follows: Figure 3 As shown, the computer device includes a processor, memory, network interface, and database connected via a system bus. The processor provides computing and control capabilities. The memory includes a non-volatile storage medium and internal memory. The non-volatile storage medium stores the operating system, computer programs, and database. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage medium. When executed by the processor, the computer program implements an ion cloud control method.

[0083] Those skilled in the art will understand that Figure 3 The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the computer device to which the present application is applied. Specific computer devices may include more or fewer components than those shown in the figure, or combine certain components, or have different component arrangements.

[0084] In one embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor executes the computer program to perform the following steps: applied to a bar mass analyzer; the bar mass analyzer includes: a quadrupole system or a multipole system, a first electrode, and a second electrode; the first electrode is disposed at the input end of the quadrupole system or the multipole system; the second electrode is disposed at the output end of the quadrupole system or the multipole system.

[0085] The ion cloud control method includes:

[0086] In response to the input of the ion cloud, the induced electrical signal generated on the first electrode is received;

[0087] The induced electrical signal is filtered.

[0088] Based on the filtered induced electrical signal, an ion cloud control signal is generated.

[0089] The ion cloud control signal is applied to the second electrode to adjust the motion time of the ion cloud in the quadrupole system or the multipole system.

[0090] In one embodiment, the filtering process of the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0091] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out the portion of the induced electrical signal above 2kHz to obtain a filtered induced electrical signal.

[0092] In one embodiment, the ion cloud control signal is specifically a square wave.

[0093] In one embodiment, the ion cloud control signal is specifically a square wave signal with a linearly varying rising edge.

[0094] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0095]

[0096] Where t1 represents the start time of the rising edge of the square wave signal; t2 represents the end time of the rising edge of the square wave signal; v2 represents the pulse amplitude of the basic square wave; and v1 represents the pulse amplitude of the basic exponential function.

[0097] In one embodiment, applying the ion cloud control signal to the second electrode to adjust the motion time of the ion cloud in the quadrupole system or the multipole system specifically includes: the motion time of each ion in the ion cloud is between 47 μs and 53 μs.

[0098] Those skilled in the art will understand that all or part of the processes in the methods of the above embodiments can be implemented by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer-readable storage medium, and when executed, it can include the processes of the embodiments of the above methods. Any references to memory, storage, databases, or other media used in the embodiments provided in this application can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), dual data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link DRAM (SLDRAM), Rambus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0099] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The above description is merely a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principles of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. A method for controlling ion clouds, characterized in that, This technology is applied to a bar-type mass analyzer; the bar-type mass analyzer includes: a multipole system, a first electrode, and a second electrode; the first electrode is disposed at the input end of the multipole system; the second electrode is disposed at the output end of the multipole system. The ion cloud control method includes: In response to the input of the ion cloud, the induced electrical signal generated on the first electrode is received; The induced electrical signal is filtered. Based on the filtered induced electrical signal, an ion cloud control signal is generated; specifically, the ion cloud control signal is a square wave signal whose rising edge satisfies the following equation: ； in, Indicates the start time of the rising edge of the square wave signal; This indicates the termination time of the rising edge of the square wave signal; This represents the pulse amplitude of the fundamental square wave; Indicates the pulse amplitude of the fundamental exponential function; The ion cloud control signal is applied to the second electrode to adjust the motion time of the ion cloud in the multipole system.

2. The ion cloud control method according to claim 1, characterized in that, The filtering process for the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

3. The ion cloud control method according to claim 2, characterized in that, The low-pass filtering process for the induced electrical signal specifically includes: filtering out the portion of the induced electrical signal above 2KHz to obtain the filtered induced electrical signal.

4. The ion cloud control method according to claim 1, characterized in that, The ion cloud is composed of several ions; The motion time specifically refers to the fact that the motion time of each ion in the ion cloud is between 47 and 100 seconds. ~53 .

5. The ion cloud control method according to claim 1, characterized in that, The multipole system includes: a quadrupole system.

6. An ion cloud control device applied to a bar mass analyzer; The bar-type mass analyzer includes: A multipole system, a first electrode, and a second electrode; the first electrode is disposed at the input end of the multipole system. The second electrode is disposed at the output end of the multipole system; The ion cloud control device is characterized in that it comprises: A receiving unit is used to receive an induced electrical signal generated on the first electrode in response to the input of the ion cloud; A filtering unit is used to filter the induced electrical signal; The generation unit is used to generate an ion cloud control signal based on the filtered induced electrical signal; the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation: ； in, Indicates the start time of the rising edge of the square wave signal; This indicates the termination time of the rising edge of the square wave signal; This represents the pulse amplitude of the fundamental square wave; Indicates the pulse amplitude of the fundamental exponential function; An adjustment unit is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the multipole system.

7. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by the processor, it implements the ion cloud control method as described in any one of claims 1-5.

8. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that, When the processor executes the computer program, it implements the ion cloud control method as described in any one of claims 1-5.

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