Rapid axial acceleration collision cell, mass spectrometer and control method of collision cell

Abstract

The invention provides a rapid axial acceleration collision cell, a mass spectrometer and a control method of the collision cell, the collision cell comprises four pole rods, the four pole rods are arranged in a rectangular shape, the four pole rods are all bent into semicircles, the bending radius of two pole rods is a first bending radius, and the bending radius of the other two pole rods is a second bending radius; four groups of auxiliary electrodes, each group of auxiliary electrodes being arranged between two adjacent pole rods, each group of auxiliary electrodes being bent in a semi-arc shape; an ion channel is formed in a region enclosed by the four groups of auxiliary electrodes, and the ion channel is provided with a semicircular arc-shaped first bending axis; the radial size of the ion channel gradually changes, and the radial size of the inlet is smaller than that of the outlet, so that the ion channel is in an ox horn shape; a sine wave radio frequency voltage and a direct current bias voltage are applied to the pole rod, and a stepped direct current bias voltage is applied to the auxiliary electrode. The collision pool provided by the invention can eliminate the fringe field effect, avoid quality discrimination, reduce the crosstalk rate and improve the dissociation efficiency.

Description

Technical Field

[0001] The present disclosure generally relates to the technical field of instruments, and particularly relates to a rapid axial acceleration collision cell, a mass spectrometer, and a control method for the collision cell. Background Art

[0002] As a core component of a triple quadrupole mass spectrometer, the design of the collision cell directly affects the ion transmission efficiency, dissociation effect, and detection throughput.

[0003] In the prior art, the collision cell mainly adopts a multipole rod structure or ion funnel technology, but there are still significant defects: the invention patent with the patent number CN116153758A discloses an off-axis linear acceleration collision cell, which combines a segmented quadrupole rod and a bent quadrupole rod to achieve ion acceleration and reduce ion crosstalk. However, the segmented structure of the quadrupole rod has a serious edge field effect, resulting in ion loss; the invention patent with the patent number CN115360076A discloses a collision reaction cell based on an ion funnel, which can better guide ions and reduce ion loss. However, this method has a single control mode and certain mass discrimination, and will filter out ions in a specific mass range, with low versatility. Summary of the Invention

[0004] In view of the above defects or deficiencies in the prior art, it is desired to provide a rapid axial acceleration collision cell, a mass spectrometer, and a control method for the collision cell to solve the above problems.

[0005] The first aspect of the present application provides a rapid axial acceleration collision cell, including: Four pole rods, the four pole rods are arranged in a rectangle, and the four pole rods are all bent into semi-circular arcs. The bending radius of two of the pole rods is the first bending radius, and the bending radius of the other two pole rods is the second bending radius, and the first bending radius is greater than the second bending radius; Four groups of auxiliary electrodes, each group of auxiliary electrodes is placed between two adjacent pole rods, and each group of auxiliary electrodes is bent in a semi-circular arc shape; the region surrounded by the four groups of auxiliary electrodes forms an ion channel, and the ion channel has a first bending axis in a semi-circular arc shape; the radial dimension of the ion channel changes gradually and the radial dimension of the entrance is smaller than the radial dimension of the exit, so that the ion channel is in a horn shape; A sine wave radio frequency voltage and a DC bias voltage are applied to the pole rods, and a stepped DC bias voltage is applied to the auxiliary electrodes.

[0006] According to the technical solution provided by the embodiment of the present application, the distance between two groups of the auxiliary electrodes on opposite sides of the first bending axis is a first distance, and the first distance gradually increases along a first direction, so that the radial dimension of the ion channel changes gradually; the first direction is the extending direction of the first bending axis and points from the inlet of the ion channel to the outlet of the ion channel.

[0007] According to the technical solution provided by the embodiment of the present application, each group of the auxiliary electrodes includes multiple electrode blocks and multiple insulating parts, the electrode blocks and the insulating parts are arranged alternately, and the stepped DC bias voltage is applied to the electrode blocks.

[0008] According to the technical solution provided by the embodiment of the present application, the electrode block includes a first electrode part and a second electrode part, the second electrode part is perpendicular to the first electrode part, and the second electrode part and the first electrode part form a T-shaped electrode; the first electrode part is placed on the side of the pole far from the first bending axis, and the second electrode part extends into the space between two adjacent poles.

[0009] According to the technical solution provided by the embodiment of the present application, in each group of the auxiliary electrodes, the sizes of the second electrode parts of multiple electrode blocks gradually decrease along the first direction, so that the first distance gradually increases along the first direction.

[0010] According to the technical solution provided by the embodiment of the present application, the amplitudes of the sine-wave RF voltages applied to the poles on opposite sides of the first bending axis are the same, and the phases differ by 180°.

[0011] According to the technical solution provided by the embodiment of the present application, the voltage form of the stepped DC voltage is as shown in the following formula (1): Formula (1) Where represents the number of segments of the electrode blocks in each group of the auxiliary electrodes, the electrode block closest to the inlet of the ion channel is the first segment, and the electrode block closest to the outlet of the ion channel is the th segment, represents the DC voltage applied to the th segment of the electrode block, represents a monotonic function of

[0012] According to the technical solution provided by the embodiment of the present application, the monotonic function at least includes the following forms: Formula (2) Formula (3) Formula (IV) Formula (V) Formula (VI) Wherein 、 、 represent adjustable adjustment parameters. When the ions in the ion channel are positive ions, the adjustment parameters are adjusted to be greater than or equal to 0. When the ions in the ion channel are negative ions, the adjustment parameters are adjusted to be less than 0.

[0013] The second aspect of the present application provides a mass spectrometer, which includes the rapid axial acceleration collision cell as described above.

[0014] The third aspect of the present application provides a control method for the rapid axial acceleration collision cell as described above, including: Applying a sinusoidal radio frequency voltage and a DC bias voltage on the pole to enable the ions in the ion channel to obtain an initial kinetic energy and move along the direction of the first bending axis; Applying a stepped DC bias voltage on the auxiliary electrode to form a gradient electric field in the ion channel.

[0015] Compared with the prior art, the beneficial effects of the present application are as follows: By using four poles in cooperation with four groups of auxiliary electrodes to form an ion channel, applying a sinusoidal radio frequency voltage and a DC bias voltage on the poles, and applying a stepped DC bias voltage on the auxiliary electrodes, the synergistic effect of the poles and the auxiliary electrodes effectively suppresses the edge field effect of the traditional collision cell, reduces the scattering and loss of ions at the edge of the ion channel, improves the ion transmission efficiency, and forms a uniform and adjustable electric field in the ion channel, avoiding the problem of ion filtering in specific mass segments caused by uneven electric field distribution, enabling ions with different mass-to-charge ratios to be stably transmitted, significantly reducing the mass discrimination phenomenon, and enhancing the adaptability of the collision cell to different types of ions. In addition, the horn-shaped ion channel in cooperation with the stepped DC bias voltage forms a gradient electric field, which can accelerate the ions to move along the direction of the first bending axis and quickly pass through the collision cell, shorten the ion residence time, greatly reduce the crosstalk rate, and improve the detection throughput. Description of the Drawings

[0016] By reading the detailed description of the non-restrictive embodiments with reference to the following drawings, other features, objects, and advantages of the present application will become more obvious: Figure 1 is a schematic structural diagram of the rapid axial acceleration collision cell provided by the present application; Figure 2 is Figure 1 a cross-sectional view of the collision cell shown at the ion channel inlet end; Figure 3 isFigure 1 Cross-sectional view of the shown collision cell in the middle section of the ion channel; Figure 4 is Figure 1 Cross-sectional view of the shown collision cell at the outlet end of the ion channel; Figure 5 is a schematic plan view of the ion channel; Figure 6 is a schematic three-dimensional view of the ion channel.

[0017] Reference numerals in the drawings: 100, pole; 101, first pole; 102, second pole; 200, auxiliary electrode; 210, electrode block; 220, insulating part; 211, first electrode part; 212, second electrode part; 220, insulating part; 300, ion channel. Detailed implementation manners

[0018] The present application will be further described in detail below with reference to the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the related invention, rather than limiting the invention. Additionally, it should be noted that for the sake of description, only the parts related to the invention are shown in the drawings.

[0019] It should be noted that, without conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present application will be described in detail below with reference to the drawings and embodiments.

[0020] Embodiment 1 Please refer to Figures 1-6 , this embodiment provides a fast axial acceleration collision cell, including: Four poles 100, the four poles 100 are arranged in a rectangle, and the four poles 100 are all bent into semi-circular arcs. The bending radii of two of the poles 100 are the first bending radius, and the bending radii of the other two poles 100 are the second bending radius. The first bending radius is greater than the second bending radius; Four groups of auxiliary electrodes 200, each group of the auxiliary electrodes 200 is disposed between two adjacent poles 100, and each group of the auxiliary electrodes 200 is bent in a semi-circular arc shape; the region surrounded by the four groups of the auxiliary electrodes 200 forms an ion channel 300, and the ion channel 300 has a first bending axis in a semi-circular arc shape; the radial dimension of the ion channel 300 changes gradually and the radial dimension of the inlet is smaller than that of the outlet, so that the ion channel 300 is in a horn shape; A sine wave radio frequency voltage and a DC bias voltage are applied to the poles 100, and a stepped DC bias voltage is applied to the auxiliary electrodes 200.

[0021] Specifically, as Figure 1As shown in the figure, the collision cell provided in this embodiment includes at least four poles 100 and four groups of auxiliary electrodes 200. The four poles 100 and the four groups of auxiliary electrodes 200 are both bent into semi-circular arc shapes. The four poles 100 are all cylindrical and have the same diameter. The four poles 100 are divided into two groups according to the bending radius. Two of them in one group are the first poles 101, and the radius of the first pole 101 is the first bending radius. The other two in the other group are the second poles 102, and the bending radius of the second pole 102 is the second bending radius. The second bending radius is smaller than the first bending radius. The two first poles 101 and the two second poles 102 are coaxially arranged and arranged in a square array to form a semi-circular arc-shaped channel with a square cross-section. The two second poles 102 are used as the inner side of the channel, and the two first poles 101 are used as the outer side of the channel. The four groups of auxiliary electrodes 200 are respectively distributed between the first poles 101, between the first pole 101 and the second pole 102, and between the second poles 102. The four groups of auxiliary electrodes 200 also extend into semi-circular arc shapes corresponding to the first poles 101 and the second poles 102. The bending radius of the auxiliary electrode 200 is determined according to the bending radii of the two adjacent poles 100 on its two sides, ensuring that each auxiliary electrode 200 is placed in the middle position between two adjacent poles 100. Therefore, the four auxiliary electrodes 200 are also arranged in a rectangular array. The area surrounded by the four auxiliary electrodes 200 also forms a channel, which is used as the ion channel 300. The ion channel 300 is also semi-circular arc-shaped. The ion channel 300 has an inlet and an outlet for ions. The central axis of the ion channel 300 is the first bending axis. Before the collision reaction, the parent ions enter the ion channel 300 through the inlet and undergo a collision reaction in the ion channel 300. The daughter ions after the collision reaction leave the ion channel 300 through the outlet; as Figure 5 and Figure 6 shown, the ion channel 300 is a variable-diameter channel, and the radial dimension of the ion channel 300 gradually increases from the inlet of the ion channel 300 to the outlet of the ion channel 300, so that the ion channel 300 forms a structure similar to a horn shape.

[0022] Specifically, when the collision cell works, a sine-wave radio frequency voltage and a DC bias voltage are applied to the poles 100, and a stepped DC bias voltage is applied to the auxiliary electrodes 200. The main functions of the sine radio frequency voltage and the DC bias voltage are to confine and guide ions. The main function of the stepped DC bias voltage is to allow ions to undergo sufficient induced dissociation while quickly passing through the ion channel 300, accelerating the ion refresh rate and reducing the crosstalk between ions.

[0023] The collision cell provided in this embodiment, through the synergistic effect of the pole 100 and the auxiliary electrode 200, effectively suppresses the edge field effect of the traditional collision cell, reduces the scattering and loss of ions at the edge of the ion channel, and improves the ion transmission efficiency; by setting the ion channel in a horn shape and combining with the voltages applied on the pole 100 and the auxiliary electrode 200, a uniform and adjustable electric field is formed in the ion channel, avoiding the problem of ion filtering in specific mass segments caused by uneven electric field distribution, enabling the stable transmission of ions with different mass-to-charge ratios, significantly reducing the mass discrimination phenomenon, enhancing the adaptability of the collision cell to different types of ions, and the horn-shaped ion channel cooperates with the stepped DC bias voltage to form a gradient electric field, which can accelerate the movement of ions along the first bending axis direction and quickly pass through the collision cell, shortening the ion residence time, greatly reducing the crosstalk rate, and improving the detection throughput.

[0024] Further, the distance between two sets of the auxiliary electrodes 200 on opposite sides of the first bending axis is a first distance, and the first distance gradually increases along a first direction, so that the radial dimension of the ion channel 300 gradually changes; the first direction is the extending direction of the first bending axis and points from the entrance of the ion channel 300 to the exit of the ion channel 300.

[0025] Specifically, the diameter change of the ion channel 300 is realized by adjusting the distance between the opposite auxiliary electrodes 200. Among the four sets of auxiliary electrodes 200 arranged in a square array, the distance between two auxiliary electrodes located on opposite sides of the first bending axis is used as the first distance. Further, the four sets of auxiliary electrodes 200 are divided into two groups in pairs. From one end of the ion channel 300 at the entrance to the other end of the ion channel 300 at the exit, that is, along the first direction, by gradually increasing the first distance between the two groups of auxiliary electrodes 200, the radial dimension of the ion channel 300 is gradually increased.

[0026] Further, each set of the auxiliary electrodes 200 includes multiple electrode blocks 210 and multiple insulating parts 220, the electrode blocks 210 and the insulating parts 220 are arranged alternately, and the stepped DC bias voltage is applied on the electrode blocks 210.

[0027] Specifically, the semi-circular arc-shaped auxiliary electrode 200 is composed of multiple electrode blocks 210 and multiple insulating parts 220 arranged alternately. The electrode blocks 210 are made of conductive materials, the insulating parts 220 are made of insulating materials, the length of the electrode blocks 210 is much greater than the length of the insulating parts 220, and the stepped DC bias voltage is applied on the multiple electrode blocks 210. Through the stepped DC bias voltage applied on the multiple electrode blocks 210, on the one hand, the dissociation efficiency of ions can be improved, and on the other hand, the daughter ions after the collision reaction in the ion channel 300 can leave the collision cell faster, accelerating the ion refresh rate and reducing the crosstalk between ions.

[0028] Further, the electrode block 210 includes a first electrode portion 211 and a second electrode portion 212. The second electrode portion 212 is perpendicular to the first electrode portion 211, and the second electrode portion 212 and the first electrode portion form a T-shaped electrode. The first electrode portion 211 is disposed on a side of the pole rod 100 away from the first bending axis, and the second electrode portion 212 extends between two adjacent pole rods 100.

[0029] Specifically, as Figures 2-4 shown, the cross-section of the electrode block 210 is T-shaped. The first electrode portion 211 and the second electrode portion 212 are of an integral structure. The first electrode portion 211 and the second electrode portion 212 are perpendicular to each other. The second electrode portion 212 extends between two adjacent pole rods 100. The first electrode portion 211 is disposed on a side of the two side pole rods 100 away from the first bending axis, and the width of the first electrode portion 211 is similar to the distance between two adjacent pole rods 100.

[0030] Further, in each group of the auxiliary electrodes 200, the sizes of the second electrode portions 212 of multiple electrode blocks 210 gradually decrease along the first direction, so that the first distance gradually increases along the first direction.

[0031] Specifically, the gradual increase of the first distance is not achieved by moving the electrode blocks 210 at corresponding positions on the opposite auxiliary electrodes 200 away from each other, but by reducing the sizes of the first electrode portions 211 of the electrode blocks 210 at two opposite positions. The sizes of the first electrode portions 211 of multiple electrode blocks 210 on each group of auxiliary electrodes 200 gradually decrease along the first direction, so that the first distance gradually increases along the first direction, and further the radial size of the ion channel 300 gradually increases along the first direction. Such a setting only changes the radial size of the ion channel 300 and ensures that the radial size of the collision cell remains unchanged.

[0032] Further, the voltage form of the stepped DC voltage applied is as shown in the following formula (1): Formula (1) Where represents the number of segments of the electrode blocks 210 in each group of the auxiliary electrodes 200. The electrode block 210 closest to the inlet of the ion channel 300 is the first segment, and the electrode block 210 closest to the outlet of the ion channel 300 is the segment. represents the DC voltage applied to the segment of the electrode block 210, represents a monotonic function of

[0033] Specifically, in this embodiment, the voltage signals applied to each electrode block 210 in the same group of auxiliary electrodes 200 are different, but the voltage signals applied to each electrode block 210 change in a stepped manner. The purpose is to allow the ions to be fully induced and dissociated while quickly passing through the collision cell to avoid ion crosstalk.

[0034] Further, the monotonic function includes at least the following several forms: Formula (II) Formula (III) Formula (IV) Formula (V) Formula (VI) where , , represent adjustable adjustment parameters. When the ions in the ion channel 300 are positive ions, the adjustment parameters are adjusted to be greater than or equal to 0. When the ions in the ion channel 300 are negative ions, the adjustment parameters are adjusted to be less than 0.

[0035] The above gives several functional forms of the applied stepped DC bias voltage. The functions include linear relationships and non-linear relationships. Specifically, different forms of stepped DC bias voltages form different types of axial electric fields to adapt to the passing time of ions with different collision cross-sections under different collision conditions, meet the needs of various types of ions, and are more flexible to use. The selection of the functional form of the stepped DC bias voltage and the value of the adjustment parameter are set by the experimenter according to the needs. The specific setting refers to the experimental requirements. It should be noted that the setting of the adjustment parameter value needs to consider the electric property of the ions. For positive ions, the selected adjustment parameter should be a positive value, and for negative ions, the selected adjustment parameter should be a negative value.

[0036] The several forms of the monotonic function given above are not all. The experimenter can also design other forms of to meet more requirements.

[0037] Further, the amplitudes of the sine-wave RF voltages applied to the pole rods 100 on opposite sides of the first bending axis are the same, and the phases differ by 180°.

[0038] Specifically, the DC bias voltages applied to the four poles 100 are the same, and the sine-wave RF voltages applied to the four poles 100 are different. In this embodiment, the four poles 100 are divided into two groups. Two poles 100 located on opposite sides of the first bending axis form a group, and the two groups of poles 100 are denoted as group A and group B respectively. The DC bias voltages applied to the poles 100 in group A and group B are the same, and the sine-wave RF voltages applied to the poles 100 in group A and group B are represented by the following formula (VII) and formula (VIII): Formula (VII) Formula (VIII) Wherein, represents the voltage signal applied to the poles 100 in group A, represents the voltage signal applied to the poles 100 in group B, represents the amplitude of the sine wave, represents the mass-to-charge ratio of the ions, represents the RF frequency applied to the poles 100, represents the time, represents the amplitude of the DC bias voltage applied to the poles 100.

[0039] According to formula (VII) and formula (VIII), at the same moment, the amplitudes of the sine-wave RF voltages applied to the poles 100 in the same group are the same and the phases are also the same; the amplitudes of the sine-wave RF voltages applied to the poles 100 in different groups are the same, and the phases differ by 180°.

[0040] The sine-wave RF voltage has a binding effect on the ions, while the DC bias voltage can enable the ions to obtain an initial kinetic energy before entering the collision cell and can move along the axis, so as to smoothly enter the ion channel 300.

[0041] Embodiment 2 This embodiment provides a mass spectrometer, which includes the rapid axial acceleration collision cell as described in Embodiment 1.

[0042] Specifically, the mass spectrometer provided in this embodiment uses the rapid axial acceleration collision cell provided in Embodiment 1 as the collision cell of the mass spectrometer, so that when the mass spectrometer is working, it can effectively bind and guide the ions, and can allow the ions to undergo sufficient induced dissociation while quickly passing through the ion channel 300 to avoid ion crosstalk. In addition, the horn-shaped ion channel 300 cooperates with the applied voltage to generate an axial electric field, so that the ions entering the collision cell can be accelerated to leave, thereby improving the refresh efficiency.

[0043] Embodiment 3 This embodiment provides a control method for the rapid axial acceleration collision cell as described in the embodiment, including: S1: Apply a sinusoidal radio frequency voltage and a DC bias voltage to the pole rod 100, so that the ions in the ion channel 300 obtain an initial kinetic energy and move along the direction of the first bending axis; S2: Apply a stepped DC bias voltage to the auxiliary electrode 200, so as to form a gradient electric field in the ion channel 300.

[0044] Through the control method provided by this embodiment, on the one hand, ions can be effectively confined and guided, allowing the ions to undergo sufficient induced dissociation while quickly passing through the ion channel 300, avoiding ion crosstalk and improving the refresh efficiency. On the other hand, it can adapt to different ions and more precisely control the passing time and dissociation process of ions, improving the versatility of the collision cell.

[0045] The above description is only a preferred embodiment of the present application and an explanation of the applied technical principles. Those skilled in the art should understand that the scope of the invention involved in the present application is not limited to the technical solution formed by the specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the inventive concept. For example, the technical solutions formed by mutually replacing the above features with the technical features (but not limited to) having similar functions disclosed in the present application.

Claims

1. A rapid axial acceleration collision cell, characterized in that: include: Four poles (100), the four poles (100) being arranged in a rectangular shape, the four poles (100) being bent into semicircular arcs, wherein the bending radii of two of the poles (100) are first bending radii, and the bending radii of the other two of the poles (100) are second bending radii, and the first bending radius is greater than the second bending radius; Four groups of auxiliary electrodes (200), each group of the auxiliary electrodes (200) being disposed between two adjacent poles (100), and each group of the auxiliary electrodes (200) being bent in a semicircular arc shape; an area surrounded by the four groups of auxiliary electrodes (200) forming an ion channel (300), the ion channel (300) having a first bending axis in a semicircular arc shape; the radial dimension of the ion channel (300) gradually changes, and the radial dimension of the inlet is smaller than the radial dimension of the outlet, so that the ion channel (300) is in a bull horn shape; A sinusoidal radio frequency voltage and a direct current bias voltage are applied to the pole (100), and a stepped direct current bias voltage is applied to the auxiliary electrode (200).

2. The rapid axial acceleration collision cell according to claim 1, characterized in that: The distance between the two groups of auxiliary electrodes (200) on opposite sides of the first bending axis is a first distance, and the first distance gradually increases along a first direction so that the radial size of the ion channel (300) gradually changes; the first direction is the extension direction of the first bending axis, and points from the entrance of the ion channel (300) to the exit of the ion channel (300).

3. The rapid axial acceleration collision cell according to claim 2, characterized in that: Each group of auxiliary electrodes (200) comprises a plurality of sections of electrode blocks (210) and a plurality of sections of insulating parts (220); the electrode blocks (210) and the insulating parts (220) are arranged alternately, and the stepped DC bias voltage is applied to the electrode blocks (210).

4. The rapid axial acceleration collision cell according to claim 3, characterized in that: The electrode block (210) comprises a first electrode portion (211) and a second electrode portion (212), the second electrode portion (212) being perpendicular to the first electrode portion (211), and the second electrode portion (212) and the first motor portion forming a T-shaped electrode; the first electrode portion (211) is disposed on a side of the pole (100) away from the first bending axis, and the second electrode portion (212) extends between two adjacent poles (100).

5. The rapid axial acceleration collision cell according to claim 4, characterized in that: In each group of the auxiliary electrodes (200), the sizes of the second electrode parts (212) of the multiple segments of the electrode blocks (210) gradually decrease along the first direction, so that the first distance gradually increases along the first direction.

6. The rapid axial acceleration collision cell according to claim 5, characterized in that: The amplitude of the sinusoidal radio frequency voltage applied to the poles (100) on opposite sides of the first bending axis is the same, and the phase difference is 180 degrees.

7. The rapid axial acceleration collision cell according to claim 6, characterized in that: The voltage form of the step DC voltage is shown in the following formula (I): Formula (I) in represents the number of segments of the electrode block (210) in each group of the auxiliary electrodes (200), the electrode block (210) closest to the entrance of the ion channel (300) is the first segment, and the electrode block (210) closest to the exit of the ion channel (300) is the second segment. part, Indicates The DC voltage applied by the electrode block (210) is express A monotonic function of .

8. The rapid axial acceleration collision cell according to claim 7, characterized in that: Monotonic function At least the following forms are included: Formula (II) Formula (III) Formula (IV) Formula (V) Formula (VI) in , , represents an adjustable adjustment parameter. When the ions in the ion channel (300) are positive ions, the adjustment parameter is adjusted to be greater than or equal to 0. When the ions in the ion channel (300) are negative ions, the adjustment parameter is adjusted to be less than 0.

9. A mass spectrometer, characterized in that The mass spectrometer comprises the rapid axial acceleration collision cell according to any one of claims 1 to 8.

10. A method for controlling a rapid axial acceleration collision cell according to any one of claims 1 to 8, characterized in that: include: Applying a sinusoidal radio frequency voltage and a direct current bias voltage to the pole (100) so that the ions in the ion channel (300) acquire initial kinetic energy and move along the first bending axis direction; A stepwise DC bias voltage is applied to the auxiliary electrode (200) to form a gradient electric field in the ion channel (300).

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