Patting type sample shaking-up instrument

Abstract

The invention discloses a slapping type sample shake-up instrument, which comprises a workbench; the swinging table is rotationally or slidably connected with the workbench; the loading frame is mounted on the swinging table, and the loading frame is configured to load a collection tube in which a sample is arranged; the driving unit is arranged on the workbench, and the driving unit is configured to drive the swing table to rotate or slide in a reciprocating mode within a preset range; the slapping frame is installed on the workbench, a slapping part is arranged on the slapping frame, and the slapping part is located in the movement range of the collecting pipe, so that the outer side wall of the collecting pipe can directly or indirectly slap the slapping part. According to the shake-up instrument, a shaking and slapping superposed mixing mode is adopted, the outer side wall of the collecting tube can directly or indirectly slap on the slapping part in the shaking process of the collecting tube, so that the collecting tube is slapped by the slapping part, a sample in the collecting tube is easily scattered after being slapped instantly, and the sample can be uniformly shaken through reciprocating shaking and multiple slapping, so that the sample can be uniformly shaken. The sample can be fully scattered and uniformly mixed.

Description

Technical Field

[0001] The present invention relates to the technical field of sample mixing, and particularly to an automatic sample mixing instrument. Background Art

[0002] Collection tubes are widely used in biochemical and clinical medical tests. At present, a large number of collection tubes are used by testing institutions to collect samples, and then it is necessary to uniformly mix some or all of the samples in the collection tubes and extract some or all of the samples in the collection tubes. Taking the preparation of platelet-rich plasma (Platelet-rich plasma, abbreviated as PRP) as an example, the blood sample is collected into a collection tube pre-filled with separating gel. After the blood sample and the separating gel in the collection tube are centrifuged and stratified, they are mainly divided into a plasma layer, a platelet layer, a separating gel layer, and a red blood cell layer from top to bottom in sequence. First, most of the plasma in the plasma layer is drawn out with a syringe to obtain platelet-poor plasma (Platelet-poor plasma, abbreviated as PPP), and a small part of plasma remains in the collection tube. Then, the collection tube is mixed manually or by an automatic mixing instrument to fully mix the platelets with the remaining small part of plasma and form platelet-rich plasma. The separating gel layer can always isolate the platelet-rich plasma and the red blood cell layer during the mixing process. Finally, the platelet-rich plasma in the collection tube is drawn out with another syringe.

[0003] Among them, the method of manually mixing the collection tube has low efficiency, and the quality of the prepared platelet-rich plasma is uneven; the automatic mixing instrument usually uses an operation method of superimposing shaking and vibration to mix the platelets and the remaining small part of plasma in the collection tube, which can achieve a good mixing effect between the platelets and the plasma. However, the platelets at the bottom of the platelet layer are compacted, agglomerated, and settled into lumps with the separating gel after centrifugal stratification. The mixing method of superimposing shaking and vibration can only disperse some platelets and the separating gel to a certain extent, and cannot completely detach the platelets from the separating gel layer, resulting in a part of platelets still remaining on the separating gel layer. Finally, the proportion of the platelet content in the extractable platelet-rich plasma relative to the total platelet amount in the blood sample is not high, and the extraction rate of platelets needs to be improved. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. For this purpose, the present invention provides a sample shaker that can fully disperse the sample.

[0005] According to an embodiment of the present invention, a slapping - type sample shaker includes: a workbench; a swing table rotatably or slidably connected to the workbench; a loading rack disposed on the swing table, the loading rack configured to load a collection tube with a sample therein; a driving unit disposed on the workbench, the driving unit configured to drive the swing table to reciprocally rotate or slide within a preset range; a slapping rack mounted on the workbench, the slapping rack being provided with a slapping portion, the slapping portion being within the movement range of the collection tube so that the outer sidewall of the collection tube can directly or indirectly slap the slapping portion.

[0006] It has at least the following beneficial effects: This shaker adopts a mixing method of superimposing shaking and slapping. The workbench is rotatably or slidably connected to the swing table, and a loading rack is arranged on the swing table. The collection tube with the sample therein is loaded on the loading rack. The driving unit drives the swing table to reciprocally rotate or slide within a preset range, realizing the operation of reciprocally shaking the sample in the collection tube, fully mixing the sample. There is also a slapping rack mounted on the workbench, and the slapping portion on the slapping rack is exactly within the movement range of the collection tube. During the shaking process of the collection tube, the outer sidewall of the collection tube can directly or indirectly slap on the slapping portion, so that the collection tube is subjected to the slapping action of the slapping portion. After the sample in the collection tube is instantaneously slapped, it is easy to disperse the sample. Through reciprocally shaking and multiple slappings, the sample can be fully dispersed and mixed. Taking the preparation of platelet - rich plasma as an example, the slapping action of the slapping portion on the collection tube disperses the sedimentation agglomerates of platelets and separation gel in the collection tube, causes the platelets to fall off from the separation gel layer, and then mixes with the plasma, effectively reducing the platelets remaining on the separation gel layer, and significantly increasing the platelet content in the extractable platelet - rich plasma.

[0007] According to some embodiments of the present invention, a buffer structure is provided between the slapping rack, the loading rack, or between the loading rack and the swing table, and the buffer structure is configured to buffer the slapping of the slapping portion on the collection tube.

[0008] According to some embodiments of the present invention, the slapping portion includes a slapping plate and a slapping buffer layer, and the slapping buffer layer is coated on the side of the slapping plate facing the collection tube, and the slapping buffer layer is configured to buffer the slapping of the outer sidewall of the collection tube on the slapping plate.

[0009] According to some embodiments of the present invention, the inclination angle of the slapping buffer layer is the same as the inclination angle of the collection tube when it initially contacts the slapping buffer layer, and when the collection tube moves to the extreme position, the slapping buffer layer deforms.

[0010] According to some embodiments of the present invention, the slapping buffer layer is made of silica gel or foam cotton.

[0011] According to some embodiments of the present invention, the loading rack includes a mounting portion and a positioning portion. The mounting portion is mounted on the workbench. The positioning portion is defined with a positioning groove for positioning and placing the collection tube. The positioning portion and the mounting portion are connected by two groups of laterally ribbed plates distributed at intervals. A buffer chamber is jointly defined among the positioning portion, the mounting portion, and the two groups of laterally ribbed plates. The outer wall of the collection tube can directly strike the striking portion. The buffer chamber is configured to buffer the impact of the collection tube on the positioning portion by being squeezed and deformed.

[0012] According to some embodiments of the present invention, an isolation buffer layer is provided on one side of the loading rack facing the striking portion. The outer wall of the collection tube indirectly strikes the striking portion through the isolation buffer layer.

[0013] According to some embodiments of the present invention, the striking rack is provided with the striking portion on each of the two sides of the swing table. At least one loading rack is mounted on each of the two sides of the swing table. At least one collection tube is loaded on each loading rack. The outer walls of all the collection tubes on the same side of the swing table can simultaneously strike the corresponding striking portion on the striking rack.

[0014] According to some embodiments of the present invention, a rotating shaft is provided on the swing table. The rotating shaft is rotatably connected to the workbench about its own axis. The driving unit is configured to drive the swing table to reciprocally swing within a preset angular range with the rotating shaft as the rotation center.

[0015] According to some embodiments of the present invention, the driving unit includes a servo motor and a crank-rocker mechanism. The crank-rocker mechanism includes a crank, a connecting rod, and a rocker that are sequentially hinged. The output shaft of the servo motor is fixedly connected to the end of the crank far from the connecting rod. The end of the rocker far from the connecting rod is fixedly connected to the rotating shaft.

[0016] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. Description of the Drawings

[0017] The present invention will be further described below in conjunction with the drawings and embodiments, where: Figure 1 is a schematic structural diagram of an embodiment of the present invention; Figure 2 is a schematic structural diagram of an embodiment of the present invention when the swing table is in one of the extreme positions; Figure 3 is a schematic structural diagram of an embodiment of the present invention when the swing table is in the other extreme position; Figure 4This is a schematic diagram showing the cooperation between the driving unit and the swing table in an embodiment of the present invention; Figure 5 This is a schematic diagram of the structure of the loading rack in an embodiment of the present invention.

[0018] Reference numerals in the drawings: workbench 1, swing table 2, rotating shaft 21, loading rack 3, mounting part 31, positioning part 32, positioning groove 321, side rib plate 33, buffer chamber 34, collection tube 4, driving unit 5, servo motor 51, crank-rocker mechanism 52, crank 521, connecting rod 522, rocker 523, slapping frame 6, slapping part 61, slapping plate 611, slapping buffer layer 612. Detailed implementation manners

[0019] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installation, rotation, sliding, movement, connection, slapping, buffering, and deformation should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above terms in the present invention in combination with the specific content of the technical solution.

[0020] Referring to Figures 1 to 5 , the present invention discloses a slapping-type sample shaker, which includes a workbench 1, a swing table 2, a loading rack 3, a driving unit 5, and a slapping frame 6.

[0021] Among them, in an embodiment of the present invention, the workbench 1 is used as a motion reference system, and the workbench 1 remains stationary in any state. The swing table 2 is rotationally or slidably connected to the workbench 1, and the driving unit 5 is arranged on the workbench 1. The driving unit 5 is configured to drive the swing table 2 to reciprocally rotate or slide within a preset range. Referring to Figures 1 to 3 , the swing table 2 can be rotationally connected to the workbench 1, and the driving unit 5 can be a rotational driving unit, which can drive the swing table 2 to reciprocally rotate relative to the workbench 1 within a preset range; the swing table 2 can also be slidably connected to the workbench 1, and the driving unit 5 can be a linear driving unit, which can drive the swing table 2 to reciprocally slide relative to the workbench 1 within a preset range.

[0022] Referring to Figure 1 , the loading rack 3 is arranged on the swing table 2, and the loading rack 3 is configured to load the collection tube 4, and a sample is placed inside the collection tube 4. Referring to Figure 2 and Figure 3 , when the swing table 2 reciprocally rotates or slides within a preset range, the collection tube 4 also follows the swing table 2 to reciprocally rotate or slide within a preset range.

[0023] Referring to Figures 1 to 3, The slapping frame 6 is installed on the workbench 1. A slapping part 61 is provided on the slapping frame 6. The slapping part 61 is within the movement range of the collection tube 4, so that the outer wall of the collection tube 4 can directly or indirectly slap the slapping part 61. It can be understood that the outer wall of the collection tube 4 can directly slap the slapping part 61, or an isolation object can be provided on the loading rack 3 so that the outer wall of the collection tube 4 can indirectly slap the slapping part 61 through the isolation object.

[0024] This shaker adopts a mixing method that combines shaking and slapping. The collection tube 4 containing the sample is loaded on the loading rack 3. The driving unit 5 drives the swing table 2 to reciprocate within a preset range, either rotating or sliding, to realize the operation of reciprocatingly shaking the sample in the collection tube 4 and fully mixing the sample; the slapping part 61 on the slapping frame 6 is exactly within the movement range of the collection tube 4. During the shaking process of the collection tube 4, the outer wall of the collection tube 4 can directly or indirectly slap on the slapping part 61, so that the collection tube 4 is subjected to the slapping action of the slapping part 61. After the sample in the collection tube 4 is instantaneously slapped, it is easy to break up the sample. Through reciprocating shaking and multiple slappings, the sample can be fully broken up and mixed.

[0025] Taking the preparation of platelet-rich plasma as an example, the slapping action of the slapping part 61 on the collection tube 4 breaks up the sedimentation lumps of platelets and separating gel in the collection tube 4, makes the platelets fall off from the separating gel layer, and then mixes with the plasma, effectively reducing the platelets remaining on the separating gel layer, and significantly increasing the platelet content in the extractable platelet-rich plasma.

[0026] In some embodiments of the present invention, the shaker can be provided with a buffer structure. The buffer structure can specifically be provided on the slapping frame 6, or on the loading rack 3, or between the loading rack 3 and the swing table 2. The buffer structure can buffer the slapping of the slapping part 61 on the collection tube 4, prevent the collection tube 4 from cracking due to hard contact, and delay and lengthen the slapping action time of the slapping part 61 on the collection tube 4.

[0027] In some embodiments of the present invention, refer to Figures 1 to 3 , The slapping part 61 includes a slapping plate 611 and a slapping buffer layer 612. The slapping buffer layer 612 is coated on the side of the slapping plate 611 facing the collection tube 4. The slapping buffer layer 612 can be made of an elastic buffer material. The slapping buffer layer 612 is configured to buffer the slapping of the outer wall of the collection tube 4 on the slapping plate 611. That is to say, the slapping buffer layer 612 can slow down the slapping force of the slapping plate 611 on the outer wall of the collection tube 4, which can not only delay and lengthen the slapping action time of the slapping plate 611 on the outer wall of the collection tube 4, but also prevent the collection tube 4 from cracking due to hard contact and protect the collection tube 4.

[0028] The slapping buffer layer 612 can be a cuboid structure with a certain thickness. Refer to Figure 2 and Figure 3, in some embodiments of the present invention, the inclination angle of the slapping buffer layer 612 is the same as the inclination angle of the collection tube 4 when the collection tube 4 initially contacts the slapping buffer layer 612, so that when the collection tube 4 initially contacts the slapping buffer layer 612, the outer wall of the collection tube 4 is tangent to the slapping buffer layer 612 and the two are in line contact. Since the slapping buffer layer 612 is made of an elastic buffer material and can deform, by reasonably setting the movement range of the swing table 2 driven by the driving unit 5, the collection tube 4 can continue to rotate or slide slightly in the current direction after the initial contact. When the collection tube 4 moves to the limit position, the slapping buffer layer 612 generates the maximum deformation, so that the outer wall of the collection tube 4 forms a curved surface contact with the slapping buffer layer 612, further delaying and lengthening the slapping action time of the slapping plate 611 on the outer wall of the collection tube 4, and further preventing the collection tube 4 from breaking.

[0029] Among them, the slapping buffer layer 612 can specifically be made of silica gel or foamed cotton. Both silica gel and foamed cotton are good elastic buffer materials.

[0030] Referring to Figure 2 , Figure 3 and Figure 5 , in some embodiments of the present invention, the loading rack 3 includes a mounting portion 31 and a positioning portion 32. The mounting portion 31 is mounted on the workbench 1. The positioning portion 32 is defined with a positioning groove 321 for positioning and placing the collection tube 4. The collection tube 4 can also be conveniently taken out from the positioning groove 321. The positioning portion 32 and the mounting portion 31 are connected by two groups of laterally spaced side rib plates 33. A buffer chamber 34 is jointly defined among the positioning portion 32, the mounting portion 31 and the two groups of side rib plates 33.

[0031] When the positioning portion 32 is subjected to an impact force towards the mounting portion 31, the positioning portion 32 can be moderately deformed and approach the mounting portion 31, and the two groups of side rib plates 33 can also be adaptively deformed and bent, so that the buffer chamber 34 is squeezed and compressed. The buffer chamber 34 is configured to buffer the impact of the collection tube 4 on the positioning portion 32 by being squeezed and deformed. That is to say, when the outer wall of the collection tube 4 on the side facing the slapping portion 61 slaps the slapping portion 61, through the squeezing deformation of the buffer chamber 34, the impact of the positioning portion 32 on the outer wall of the collection tube 4 on the side away from the slapping portion 61 can be buffered, the slapping action time of the slapping portion 61 on the outer wall of the collection tube 4 can be delayed and lengthened, and the collection tube 4 can be prevented from hard contact and breaking, protecting the collection tube 4.

[0032] In some embodiments, referring to Figures 1 to 3The technical solution of combining the design of the buffer chamber 34 on the loading rack 3 with the design of the slapping buffer layer 612 on the slapping part 61 can make the side of the collection tube 4 close to the slapping part 61 and the side away from the slapping part 61 both be subjected to soft contact force, thereby achieving a two-way buffering effect, further preventing the collection tube 4 from being broken by hard contact, and further delaying and lengthening the slapping action time of the slapping part 61 on the outer wall of the collection tube 4.

[0033] The outer wall of the collection tube 4 can also indirectly hit the hitting part 61. In some embodiments, an isolation buffer layer is provided on the side of the loading frame 3 facing the hitting part 61. The isolation buffer layer isolates the outer wall of the collection tube 4 from the hitting part 61. The outer wall of the collection tube 4 indirectly hits the hitting part 61 through the isolation buffer layer. The isolation buffer layer can be made of elastic buffer material, specifically, can be made of silicone or foam cotton.

[0034] In some embodiments, the slapping frame 6 is provided with a slapping part 61 on both sides of the swing platform 2, and at least one loading frame 3 is installed on both sides of the swing platform 2, and each loading frame 3 is loaded with at least one collection tube 4, Figure 1 Two loading racks 3 are installed on both sides of the swing platform 2. Each loading rack 3 on one side of the swing platform 2 is loaded with a collection tube 4, and each loading rack 3 on the other side of the swing platform 2 is loaded with two collection tubes 4. The outer walls of all the collection tubes 4 on the same side of the swing platform 2 can simultaneously clap the clap part 61 on the corresponding side of the clap rack 6.

[0035] The present shaker can also adapt to the mixing operation of collection tubes 4 with different outer diameters at the same time. By reasonably setting the inner diameter and position of each positioning groove 321, after the collection tube 4 is placed in the matching positioning groove 321, it is only necessary to ensure that the maximum distance between the outer side walls of the oscillating table 2 and each collection tube 4 on the same side of the oscillating table 2 is consistent, so that the outer side walls of all the collection tubes 4 on the same side of the oscillating table 2 can simultaneously hit the hitting part 61 on the corresponding side of the hitting frame 6.

[0036] In some embodiments of the present invention, reference Figure 4 A rotating shaft 21 is provided on the swing table 2, and the rotating shaft 21 can rotate around its own axis to connect to the workbench 1. The driving unit 5 is configured to drive the swing table 2 to swing back and forth within a preset angle range with the rotating shaft 21 as the rotation center. The driving unit 5 can be connected to the rotating shaft 21 in a transmission manner, and the rotating shaft 21 drives the swing table 2 to rotate; the driving unit 5 can also be directly connected to the swing table 2 in a transmission manner, so that the swing table 2 rotates around the rotating shaft 21 as the rotation center.

[0037] Reference Figure 4, in some embodiments, the driving unit 5 includes a servo motor 51 and a crank-rocker mechanism 52. The crank-rocker mechanism 52 includes a crank 521, a connecting rod 522, and a rocker 523 that are sequentially hinged. The output shaft of the servo motor 51 is fixedly connected to one end of the crank 521 that is far from the connecting rod 522. One end of the rocker 523 that is far from the connecting rod 522 is fixedly connected to the rotating shaft 21. The output shaft of the servo motor 51 drives the swing table 2 to reciprocate within a preset angle range through the crank-rocker mechanism 52. Among them, during each rotation of the crank 521, the crank 521 is collinear with the connecting rod 522 twice. At this time, the rocker 523 is respectively in two extreme positions, so that the swing table 2 has two extreme positions. Correspondingly, the position and inclination angle of the slapping buffer layer 612 can be reasonably set, and the inclination angle of the slapping buffer layer 612 can be set to 10° - 30°.

[0038] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0039] Certainly, the present invention is not limited to the above-described embodiments. Those skilled in the art can make equivalent deformations or substitutions without departing from the spirit of the present invention. These equivalent variations or substitutions are all included in the scope defined by the claims of this application.

Claims

1. Slapping-type sample shaker, characterized in that, Comprising: A workbench (1); A swing table (2), rotatably or slidably connected to the workbench (1); A loading rack (3), arranged on the swing table (2), and the loading rack (3) is configured to load a collection tube (4) with a sample therein; A driving unit (5), arranged on the workbench (1), and the driving unit (5) is configured to drive the swing table (2) to reciprocally rotate or slide within a preset range; A slapping rack (6), mounted on the workbench (1), and a slapping portion (61) is arranged on the slapping rack (6), and the slapping portion (61) is within the movement range of the collection tube (4) so that the outer sidewall of the collection tube (4) can directly or indirectly slap the slapping portion (61).

2. The slapping type sample shaker according to claim 1, wherein, A buffer structure is provided between the slapping rack (6), the loading rack (3), or between the loading rack (3) and the swing table (2), and the buffer structure is configured to buffer the slapping of the slapping portion (61) on the collection tube (4).

3. The slapping type sample shaker according to claim 2, characterized in that, The slapping portion (61) includes a slapping plate (611) and a slapping buffer layer (612), and the slapping buffer layer (612) covers the side of the slapping plate (611) facing the collection tube (4), and the slapping buffer layer (612) is configured to buffer the slapping of the outer sidewall of the collection tube (4) on the slapping plate (611).

4. The slapping type sample shaker according to claim 3, characterized in that, The inclination angle of the slapping buffer layer (612) is the same as the inclination angle of the collection tube (4) when initially contacting the slapping buffer layer (612), and when the collection tube (4) moves to the extreme position, the slapping buffer layer (612) deforms.

5. The slapping type sample shaker according to claim 4, wherein, The slapping buffer layer (612) is made of silica gel or foamed cotton.

6. The slapping type sample shaker according to any one of claims 2 to 5, characterized in that, The loading rack (3) includes a mounting portion (31) and a positioning portion (32), the mounting portion (31) is mounted on the workbench (1), the positioning portion (32) is defined with a positioning groove (321) for positioning and placing the collection tube (4), the positioning portion (32) is connected to the mounting portion (31) by two groups of laterally spaced rib plates (33), and a buffer chamber (34) is jointly defined among the positioning portion (32), the mounting portion (31), and the two groups of rib plates (33). The outer sidewall of the collection tube (4) can directly slap the slapping portion (61), and the buffer chamber (34) is configured to buffer the impact of the collection tube (4) on the positioning portion (32) by being squeezed and deformed.

7. The slapping type sample shaker according to any one of claims 2 to 5, characterized in that, An isolation buffer layer is provided on the side of the loading rack (3) facing the slapping portion (61), and the outer sidewall of the collection tube (4) indirectly slaps the slapping portion (61) through the isolation buffer layer.

8. The slapping type sample shaker according to claim 1, wherein, The slapping rack (6) is provided with the slapping portion (61) on both sides of the swing table (2), at least one loading rack (3) is mounted on both sides of the swing table (2), each loading rack (3) loads at least one collection tube (4), and the outer sidewalls of all the collection tubes (4) on the same side of the swing table (2) can simultaneously slap the slapping portion (61) on the corresponding side of the slapping rack (6).

9. The slapping type sample shaker according to claim 1, 2, 3, 4, 5 or 8, characterized in that, A rotating shaft (21) is provided on the swing table (2). The rotating shaft (21) is rotatably connected to the workbench (1) about its own axis. The driving unit (5) is configured to drive the swing table (2) to reciprocally swing within a preset angle range with the rotating shaft (21) as the rotation center.

10. The slapping type sample shaker according to claim 9, characterized in that, The driving unit (5) includes a servo motor (51) and a crank-rocker mechanism (52). The crank-rocker mechanism (52) includes a crank (521), a connecting rod (522), and a rocker (523) that are sequentially hinged. The output shaft of the servo motor (51) is fixedly connected to one end of the crank (521) that is far from the connecting rod (522). One end of the rocker (523) that is far from the connecting rod (522) is fixedly connected to the rotating shaft (21).

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