Microbubble control methods, devices, equipment, media and products

Abstract

The application provides a micro-bubble control method, device, equipment, medium and product. The method comprises the following steps: obtaining a preset first mapping relationship, the first mapping relationship comprising a corresponding relationship between an opening direction of a plurality of micro-bubble structures, a plurality of opening sizes, a plurality of ultrasonic frequencies and a plurality of flow field directions, the flow field direction being a flow direction of a fluid, and the ultrasonic frequency being a frequency of an ultrasonic wave applied to the micro-bubble structure; obtaining a preset second mapping relationship, the second mapping relationship comprising a one-to-one corresponding relationship between the opening size of the plurality of micro-bubble structures and the size of a plurality of target substances; obtaining a target size of the target substance and a target delivery position of the target substance; and delivering the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship. The embodiment of the application can improve the delivery effect of the target substance.

Description

Technical Field

[0001] This application relates to the field of ultrasonic control technology, and in particular to a microbubble control method, apparatus, equipment, medium and product. Background Technology

[0002] Malignant tumors are a serious threat to people's lives and health. Traditional cancer treatments lack precision and targeting capabilities, often causing harm to patients during treatment. How to rapidly and controllably deliver drug payloads to the lesion area through extremely small blood vessels has become a major clinical challenge in cancer treatment. Researching and solving this problem has broad medical and economic prospects.

[0003] In existing technologies, magnetic field-driven methods are commonly used to deliver drugs in blood vessels. However, current magnetic field-driven methods have limitations such as large control system devices that cannot be miniaturized, difficulty in integrating with microfluidic chips, and specific requirements for the driven object, resulting in unsatisfactory drug delivery effects. Summary of the Invention

[0004] This application provides a microbubble control method, apparatus, equipment, medium, and product that can improve the delivery effect of target substances.

[0005] In a first aspect, embodiments of this application provide a microbubble control method applied to a microbubble structure. The microbubble structure is disposed within a microcavity structure, and fluid flows within the microcavity structure. The microbubble structure is used to deliver a target substance. The method includes:

[0006] Obtain a preset first mapping relationship, which includes the correspondence between the opening orientation of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions. The flow field direction is the direction of fluid flow, and the ultrasonic frequency is the frequency of the ultrasonic waves applied to the microbubble structure.

[0007] Obtain a preset second mapping relationship, which includes a one-to-one correspondence between the opening sizes of multiple microbubble structures and the sizes of multiple target substances;

[0008] Obtain the target dimensions of the target material and its target delivery location;

[0009] Based on the first matching relationship between the target delivery location and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, the target material is delivered to the target location.

[0010] Secondly, this application provides a microbubble control device applied to a microbubble structure. The microbubble structure is disposed within a microcavity structure, and fluid flows within the microcavity structure. The microbubble structure is used to deliver a target substance. The device includes:

[0011] The first acquisition module is used to acquire a preset first mapping relationship. The first mapping relationship includes the correspondence between the opening orientation of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions. The flow field direction is the direction of fluid flow, and the ultrasonic frequency is the frequency of ultrasonic waves applied to the microbubble structure.

[0012] The second acquisition module is used to acquire a preset second mapping relationship, which includes a one-to-one correspondence between the opening sizes of multiple microbubble structures and the sizes of multiple target substances.

[0013] The third acquisition module is used to acquire the target size of the target material and the target delivery location of the target material;

[0014] The delivery module is used to deliver the target material to the target location based on a first matching relationship between the target delivery location and a first mapping relationship, and a second matching relationship between the target size and a second mapping relationship.

[0015] Thirdly, embodiments of this application provide an electronic device, which includes: a processor and a memory storing computer program instructions;

[0016] When the processor executes computer program instructions, it implements the microbubble control method as described in any of the embodiments of the first aspect.

[0017] Fourthly, embodiments of this application provide a computer storage medium storing computer program instructions, which, when executed by a processor, implement the microbubble control method as described in any of the embodiments of the first aspect.

[0018] Fifthly, embodiments of this application provide a computer program product in which instructions, when executed by a processor of an electronic device, cause the electronic device to perform the microbubble control method as described in any of the embodiments of the first aspect above.

[0019] In a microbubble control method, apparatus, device, medium, and product provided in this application embodiment, a preset first mapping relationship is obtained. This first mapping relationship includes the correspondence between the opening orientation, opening size, ultrasonic frequency, and flow field direction of multiple microbubble structures. The flow field direction is the direction of fluid flow, and the ultrasonic frequency is the frequency of ultrasound applied to the microbubble structure. A preset second mapping relationship is obtained. This second mapping relationship includes a one-to-one correspondence between the opening size of multiple microbubble structures and the size of multiple target substances. The target size of the target substance and its target delivery location are obtained. Based on a first matching relationship between the target delivery location and the first mapping relationship, and a second matching relationship between the target size and the second mapping relationship, the target substance is delivered to the target location. This method, by obtaining the correspondence between the opening orientation, size, and ultrasonic frequency of the microbubble structure and the flow field direction, achieves highly precise control of fluid flow. This ensures accurate drug delivery within the microcavity structure and allows for rapid and intuitive adaptation to the microenvironment. By utilizing the second mapping relationship, the opening size of the microbubble structure is matched one-to-one with the size of different target materials, enabling the matching delivery of target materials of different sizes. This makes it applicable to a variety of target materials of different sizes, improving the flexibility and applicability of delivery, and thus enhancing the delivery effect of target materials. Attached Figure Description

[0020] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly introduced below. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic flowchart of a microbubble control method provided in one embodiment of this application;

[0022] Figure 2 This is a schematic diagram of the flow field distribution under different ultrasonic frequencies, different opening sizes, and different opening orientations, provided by one embodiment of this application;

[0023] Figure 3 This is a schematic diagram illustrating the relationship between the microbubble opening diameter and delivery efficiency according to one embodiment of this application;

[0024] Figure 4 This is a schematic diagram of a micro vortex for screening particles of different sizes, provided in one embodiment of this application;

[0025] Figure 5 This is a schematic diagram of a microbubble structure provided in one embodiment of this application;

[0026] Figure 6 This is a schematic diagram of another microbubble structure provided in one embodiment of this application;

[0027] Figure 7 This is a schematic diagram of another microbubble structure provided in one embodiment of this application;

[0028] Figure 8 This is a schematic diagram of the structure of a microbubble control device provided in an embodiment of this application;

[0029] Figure 9 This is a schematic diagram of the structure of the electronic device provided in the embodiments of this application. Detailed Implementation

[0030] To better understand the above-mentioned objectives, features, and advantages of this disclosure, the solutions disclosed herein will be further described below. It should be noted that, unless otherwise specified, the embodiments and features described herein can be combined with each other.

[0031] Numerous specific details are set forth in the following description in order to provide a full understanding of this disclosure, but this disclosure may also be implemented in other ways different from those described herein; obviously, the embodiments in the specification are only some, and not all, of the embodiments of this disclosure.

[0032] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the term "comprising" or any other variations thereof is intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0033] Malignant tumors are a serious threat to people's lives and health. Traditional cancer treatments lack precision and targeting capabilities, often causing harm to patients during treatment. How to rapidly and controllably deliver drug loads to the lesion area through extremely small blood vessels has become a major clinical challenge in cancer treatment, and researching and solving this problem has broad medical and economic prospects. At the microscale, due to the low Reynolds number effect, microfluidics exhibit significant viscosity, and traditional convection and diffusion methods cannot achieve satisfactory net flow effects. Currently, methods for generating net driving force at the microscale include external magnetic fields and acoustic field control. External magnetic field control methods can combine structures such as helices to generate directionally and velocously controllable motion in microfluidics. External acoustic field control is an effective, rapid, and high-intensity driving method; microbubbles and sharp-edge structures are used to generate high-intensity microvortices at the microscale. Microbubbles, under the influence of an acoustic field, can generate a pair of symmetrical microvortices at the gas-liquid interface; sharp-edge structures, driven by an acoustic field, can also produce good microfluidic effects due to micro-perturbations.

[0034] Currently, magnetic field-driven methods are limited by factors such as the large size of the control system, the inability to miniaturize it, the difficulty in integrating it with microfluidic chips, and the specific requirements for the driven object. Compared to magnetic field-driven methods, microscale ultrasonic actuation has gained favor in academia and business due to its greater portability, high energy intensity, on-chip integration, and ease of miniaturization. Ultrasonic frequency, amplitude, and phase are the main ultrasonic actuation techniques; however, the sharp-edge structures currently used in ultrasonic actuation lack frequency specificity in microfluidics, exhibiting only a monotonically negative correlation between vortex intensity and frequency, resulting in relatively limited acoustic actuation methods at the microscale. Microbubbles are an excellent acoustic actuation carrier with frequency specificity, but their frequency difference responsiveness requires significant differences in bubble size. Furthermore, the control of microbubbles mainly focuses on intensity control for microscale mixing, aggregation, and screening, resulting in symmetrical microvortices that cannot generate net flow. Therefore, there is a lack of methods for generating asymmetric acoustic flow at the microscale, a lack of frequency-specific actuation methods for microbubble arrays of similar sizes, and a lack of selective delivery and screening applications based on frequency-specific actuation methods. By enriching the driving and control methods of microscale acoustics, it has potential applications in microfluidic actuation, microfluidic orientation selection, and selective screening under specific microfluidic orientations.

[0035] To address the problems existing in the prior art, embodiments of this application provide a microbubble control method, apparatus, device, medium, and product.

[0036] This application provides a microbubble control method, apparatus, device, medium, and product. The microbubble control method provided in this application will be described first. For example... Figure 1As shown, this method is applied to a microbubble structure, where the microbubble structure is set within a microcavity structure, and fluid flows through the microcavity structure. The microbubble structure is used to deliver target substances, and the method specifically includes the following steps:

[0037] S100, obtain a preset first mapping relationship. The first mapping relationship includes the correspondence between the opening orientation of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions. The flow field direction is the direction of fluid flow, and the ultrasonic frequency is the frequency of the ultrasonic waves applied to the microbubble structure.

[0038] Optionally, in the embodiments of this application, a microbubble structure refers to a structure formed by small gas-encapsulated bubbles at the microscopic scale. These tiny bubbles can be embedded in liquids or other media and have dimensions ranging from micrometers to millimeters. Microbubble structures can generate microfluidic effects in ultrasonic fields for drug delivery, mixing, or other microscale operations.

[0039] Microcavity structures refer to channels or tubes formed at the microscale, typically in the micrometer range. These microcavities can be constructed from microfluidic chips, microfluidic devices, or other microsystem components. The design of microcavity structures enables precise manipulation and analysis of minute amounts of liquids. The fluid flowing within the microcavity can be a liquid, including solutions, suspensions, or other forms of fluid media. The fluid within the microcavity can be subjected to external stimuli, such as ultrasound, to achieve precise flow control and drug delivery.

[0040] Optionally, in the embodiments of this application, the target substance refers to the main object or substance of interest that is studied or processed in a specific application scenario. That is, the target substance refers to the substance that needs to be delivered through a microbubble structure, which may involve fields such as medicine, drug delivery, and biology. The target substance can be a variety of substances, depending on the needs of the research or application. For example, the target substance can be various drugs used to treat diseases or achieve therapeutic effects; the target substance can also be a marker in a biological body used to detect, label, or study biological processes; the target substance may also be cells used for specific cell therapy or research; the target substance can be nanoparticles used for delivery, loading, or research at the nanoscale; the target substance may include various living molecules, such as proteins and nucleic acids, used for biomedical research or treatment; the target substance can also be a fluorescent marker used to achieve bioimaging or track specific molecules.

[0041] Optionally, in one feasible implementation of this application, a series of experiments can be conducted first to obtain data by observing the behavior of the microbubble structure under different conditions. For example, the motion of microbubbles in an ultrasonic field can be observed using a microscope, and the behavior under different ultrasonic frequencies, opening sizes, and flow field directions can be recorded. Alternatively, computational fluid dynamics or other numerical simulation methods can be used to simulate the behavior of microbubbles under different conditions in a computer. By adjusting parameters such as ultrasonic frequency, opening size, and flow field direction, a series of simulation data can be generated. Finally, after obtaining these experimental or simulation data, the relationship between the opening orientation, opening size, ultrasonic frequency, and flow field direction of the microbubble structure can be determined through statistical analysis or by establishing a mathematical model, forming a first mapping relationship. This relationship will provide a basis for subsequent applications to better control the behavior of the microbubble structure under specific conditions.

[0042] S200, obtain a preset second mapping relationship, which includes a one-to-one correspondence between the opening sizes of multiple microbubble structures and the sizes of multiple target substances.

[0043] Alternatively, in one feasible implementation of this application, a series of experiments can be conducted first to obtain data by measuring the opening size of the microbubble structure and the size of the target material. Tools such as microscopes can be used to measure the specific characteristics of the microbubbles, while simultaneously obtaining the size information of the target material through experimental methods.

[0044] Alternatively, image processing and analysis techniques can be used to process images of the microbubble structure and the target material. This allows for the quantification of the microbubble opening size and the size of the target material, establishing the relationship between them. Alternatively, computational methods can be employed, using numerical simulation tools to simulate the behavior of the microbubble structure and the target material in a computer. By adjusting parameters such as the opening size, a series of simulation data can be generated, and the correlations between them can be analyzed.

[0045] The above methods can be used to collect data on the relationship between the opening size of the microbubble structure and the size of the target material. This data can be used to establish a second mapping relationship, providing a basis for subsequent applications to better control the effectiveness of the microbubble structure in delivering the target material.

[0046] S300: Obtain the target dimensions of the target material and the target delivery location of the target material.

[0047] Optionally, in one specific implementation of this application, assuming the target substance is a drug, medical imaging techniques, such as magnetic resonance imaging and computed tomography, can be used to obtain detailed information such as the morphology and size of the lesion or target tissue. This information can be used as a basis for determining the target size and delivery location of the target substance. Pathological examination of the patient can also be performed, and detailed information about the target tissue, including cell structure and size, can be obtained through histological analysis, which also helps determine the delivery location and size of the target substance. Alternatively, the clinical diagnosis of a clinician, combined with the patient's medical history and symptoms, can preliminarily determine the location and size of the lesion, serving as the basis for target substance delivery.

[0048] In other implementations, in medical imaging, contrast agents or markers can be used to highlight lesions, thereby allowing for clearer observation of the location and size of the target tissue. Alternatively, based on individualized patient data, including physiological parameters and pathological features, computational models or algorithms can be used to predict the target size and delivery location of the target substance. These methods allow for the acquisition of information on the target size and delivery location of the target substance to varying degrees, guiding drug delivery strategies.

[0049] Alternatively, in another implementation of this application, for living cells, live cell microscopy and fluorescence imaging techniques can be used to monitor the distribution of markers within the cells, allowing observation of cell morphology and marker location. For fluorescent markers, the markers can be associated with spatial markers within cells or tissues, such as organelles or cell membranes. By observing the position of the markers relative to these structures, the delivery location of the markers can be indirectly determined.

[0050] S400, based on a first matching relationship between the target delivery location and a first mapping relationship, and a second matching relationship between the target size and a second mapping relationship, the target material is delivered to the target location.

[0051] Optionally, in one specific implementation of this application, the actual size of the target material, such as particle size or cell diameter, can first be obtained using appropriate measurement methods. Then, based on specific needs and treatment goals, the ideal delivery location of the target material within the microcavity structure is determined; this could be the lesion area or other specific locations requiring treatment. Subsequently, through experiments or literature review, the relationship between the target delivery location and the opening orientation, opening size, ultrasonic frequency, and flow field direction of the microbubble structure can be established. This can be an empirical matching relationship, derived through multiple experiments. Then, based on the first matching relationship, appropriate ultrasonic frequency, microbubble opening orientation, size, and flow field direction can be selected to generate a flow field effect suitable for the target delivery location. Finally, through the action of ultrasound, the microbubble structure generates a fluid flow field within the microcavity structure, delivering the target material along a predetermined path to the target location. Through this process, the target material can be precisely delivered to the target location by using ultrasound-driven microbubble structures, based on its size and delivery location, thereby improving the delivery effect.

[0052] In a microbubble control method provided in this application embodiment, a preset first mapping relationship is obtained. This first mapping relationship includes the correspondence between the opening orientation, opening size, ultrasonic frequency, and flow field direction of multiple microbubble structures. The flow field direction is the direction of fluid flow, and the ultrasonic frequency is the frequency of ultrasound applied to the microbubble structure. A preset second mapping relationship is obtained. This second mapping relationship includes a one-to-one correspondence between the opening size of multiple microbubble structures and the size of multiple target substances. The target size of the target substance and the target delivery position of the target substance are obtained. Based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, the target substance is delivered to the target position. This method, by obtaining the correspondence between the opening orientation, size, and ultrasonic frequency of the microbubble structure and the flow field direction, achieves highly precise control of fluid flow. This ensures accurate drug delivery within the microcavity structure and allows for rapid and intuitive adaptation to the microenvironment. By utilizing the second mapping relationship, the opening size of the microbubble structure is matched one-to-one with the size of different target materials, enabling the matching delivery of target materials of different sizes. This makes it applicable to a variety of target materials of different sizes, improving the flexibility and applicability of delivery, and thus enhancing the delivery effect of target materials.

[0053] In one embodiment, step 400 above may specifically be performed as follows:

[0054] S401, Based on the target size, obtain the target opening of the microbubble structure that matches the target size from the second mapping relationship;

[0055] S402, Based on the target delivery location, determine the first delivery path of the target material in the microcavity structure;

[0056] S403, based on the first delivery path, determine the first flow field direction of the fluid;

[0057] S404, based on the first flow field direction and the target opening, obtain the first ultrasonic frequency that matches the first flow field direction from the first mapping relationship, and the first orientation of the target bubble structure, wherein the opening size of the target bubble structure is the target opening;

[0058] S405, the target bubble structure is arranged in the microcavity structure according to the first orientation, and an ultrasonic wave of the first ultrasonic frequency is applied to the target bubble structure to deliver the target substance to the target delivery location according to the first delivery path.

[0059] Optionally, in one feasible implementation of this application, firstly, using a second mapping relationship, the size of the target material is matched with the opening size of the microbubble structure to determine the target opening of the microbubble structure required for the target material. Then, through experiments or simulations, the ideal delivery path of the target material in the microcavity structure, i.e., the first delivery path, is determined. Subsequently, based on the first delivery path, the flow direction of the fluid in the microcavity structure, i.e., the first flow field direction, is determined. Using the first mapping relationship, the first flow field direction is matched with the target opening size to obtain the corresponding ultrasonic frequency and the orientation of the target bubble structure. Finally, based on the obtained first ultrasonic frequency and orientation, the target bubble structure is arranged in the microcavity structure, and then, by applying corresponding ultrasonic waves, the target material is delivered to the target delivery location along the first delivery path. This process can be achieved by controlling the parameters of the ultrasonic waves to adjust the movement of the target bubble structure, thereby achieving precise delivery of the target material.

[0060] Optionally, in one specific implementation of this application, such as Figure 2 As shown, (a) is the flow field distribution driven by ultrasonic frequency f1; (b) is the flow field distribution driven by ultrasonic frequency f2. Multiple microbubble structures are arranged in the microstructured cavity, where microbubbles 1-1, 1-2, etc., have different opening sizes, and the microbubbles with different opening sizes have different orientations within the microstructured cavity. Under ultrasonic frequency f1, a flow field is generated in the cavity that is aligned with the orientation of microbubble 1-1, such as... Figure 2 As shown in (a), a flow field is generated under ultrasonic frequency f2, oriented in the same direction as microbubbles 1-2, as shown in [a]. Figure 2 As shown in (b).

[0061] like Figure 3As shown, the opening size is related to the microbubble vortex intensity and exhibits a correlation with the ultrasonic excitation frequency. Ultrasonic delivery methods can deliver micro / nano payloads of different materials and sizes, such as magnetic and non-magnetic materials, and even deliver living cells and micro / nano robots, and can achieve long-distance delivery. Figure 4 As shown, for micro-nano payloads of different sizes, larger particles are more likely to escape the vortex, while smaller particles can escape from the vortex, thus enabling the screening of particles of different sizes (i.e., constructing a second mapping relationship).

[0062] In these alternative embodiments, precise delivery of the target substance is achieved by obtaining the corresponding microbubble structure and ultrasound parameters based on the size and delivery location of the target substance. This helps improve the delivery efficiency of therapeutic drugs, living cells, and the like at the microscale. By determining a first delivery path, the flow path of the target substance within the microcavity structure can be flexibly controlled, ensuring it reaches the target delivery location in a predetermined direction. This helps avoid complex vascular structures and improves delivery accuracy.

[0063] Utilizing ultrasound as a driving force offers advantages such as high frequency, high intensity, and high controllability, facilitating the generation of a fine flow field effect within microbubble structures and thereby promoting the net flow of the target substance. This ultrasound-driven method offers greater portability and applicability compared to traditional magnetic field-driven methods. By dynamically adjusting the ultrasound frequency and the arrangement of the bubble structure, real-time monitoring and control of the delivery process can be achieved, ensuring the immediacy and flexibility of the delivery effect. Overall, this application can improve the accuracy, speed, and controllability of target substance delivery at the microscale, providing new possibilities for the treatment of diseases such as cancer and possessing significant medical and clinical application prospects.

[0064] In one embodiment, the microbubble structure includes a plurality of first sub-bubbles, and the microchannel includes a plurality of first sub-channels; step 400 above may further perform the following steps:

[0065] S406, Based on the target size, obtain the first size range that matches the target size from the second mapping relationship;

[0066] S407, Based on the target delivery location, determine the second delivery path of the target material in each first sub-cavity;

[0067] S408, For any one of the multiple first sub-cavities to be transported, the second flow field direction of the fluid in the cavity to be transported is determined based on the second delivery path corresponding to the cavity to be transported;

[0068] S409, based on the second flow field direction and the first size range, obtain the second ultrasonic frequency that matches the second flow field direction from the first mapping relationship, and the second orientation corresponding to the multiple first target sub-bubbles, the multiple first sub-bubbles including multiple first target sub-bubbles, the opening size of each first target sub-bubble within the first size range;

[0069] S410, each first target sub-bubble is arranged in the transport cavity according to the second orientation corresponding to each first target sub-bubble, and an ultrasonic wave of the second ultrasonic frequency is applied to each first target sub-bubble so that the target material flows in the transport cavity according to the second delivery path.

[0070] Optionally, in one feasible implementation of this application, the dimensions of the target microbubble structure can first be obtained using a microscope, imaging equipment, or image processing method. A first size range matching the target size is then found within a second mapping relationship. Subsequently, fluid dynamics simulations or experimental data are used to determine the movement path of the target material in each first sub-cavity. Combining the target delivery location and cavity geometry, a second delivery path for the target material in each first sub-cavity is determined. For each cavity to be transported, a second flow field direction of the fluid within that cavity is determined based on its corresponding second delivery path. Then, according to the first mapping relationship, a second ultrasonic frequency and a second orientation matching the second flow field direction and the first size range are found.

[0071] Optionally, in the embodiments of this application, such as Figure 5 As shown, by setting multiple combinations of bubbles of different sizes, 4-1, 4-2, 4-3, and 4-4 represent microbubbles with different openings. Under the control of ultrasonic signals of different frequencies, the microstructure can move controllably on a plane.

[0072] In these alternative embodiments, the size range of the microbubble structure and the delivery path of the target material in each cavity are determined based on the target size and delivery location. This enables precise control and manipulation of the target material at the microscale. By matching the parameters of the second delivery path, flow field direction, ultrasonic frequency, and bubble structure, a flow field with a specific direction is generated in the cavity to be transported. This facilitates the orderly and directional transport of fluids in a microfluidic environment. By arranging bubbles in the cavity to be transported according to the second orientation corresponding to each first target sub-bubble and applying ultrasound at the second ultrasonic frequency, efficient energy transfer of the target material is achieved. This improves delivery efficiency and reduces additional impact on the target material.

[0073] Furthermore, because this application includes multiple first sub-cavities and corresponding microbubble structures, it enables the parallel processing of multiple target materials. This multi-channel design helps improve delivery efficiency and speed. Overall, this technical solution achieves directional and precise delivery of target materials at the microscale through acoustic means, exhibiting strong controllability and applicability. It is suitable for fields such as microfluidics and micro / nano payload delivery, providing new ideas and solutions for the precise operation of microfluidic systems.

[0074] In one embodiment, the microbubble structure includes multiple bubble groups, each bubble group includes multiple second sub-bubbles, and the microchannel includes multiple second sub-channels; step 400 above may further perform the following steps:

[0075] S411, Obtain the preset third mapping relationship, which includes a one-to-one correspondence between multiple bubble groups, multiple ultrasonic frequencies, and multiple flow field directions;

[0076] S412, based on the target delivery location and the arrangement of the multiple second sub-cavities, determine the shortest delivery path of the target material in the multiple second sub-cavities, the shortest delivery path includes at least one target cavity, the target cavity is a flow cavity of the target material, and the multiple second sub-cavities include at least one target cavity.

[0077] S413, For any target sub-cavity in at least one target cavity, determine the third flow field direction of the target sub-cavity based on the sub-path corresponding to the target sub-cavity;

[0078] S414, based on the third flow field direction, obtain the target bubble group that matches the third flow field direction from the third mapping relationship, as well as the third ultrasonic frequency;

[0079] S415, the target bubble group is arranged in the target sub-cavity, and ultrasound of the third ultrasonic frequency is applied to the target bubble group to make the target material flow in the target sub-cavity according to the sub-path.

[0080] Optionally, in one feasible implementation of this application, a series of experiments or simulations can be conducted first to determine the relationship between different bubble groups, ultrasonic frequencies, and flow field directions. Through systematic testing of different parameters, the behavior of the bubble groups under different ultrasonic frequencies and flow field directions is recorded. Then, using a path planning algorithm, based on the delivery location of the target material and the arrangement of multiple second sub-cavities, the shortest delivery path is calculated. The algorithm needs to consider the spatial layout of the cavities and any physical obstacles. Subsequently, according to a preset mapping relationship, the sub-paths corresponding to the target sub-cavities are mapped to the corresponding flow field directions. It may be necessary to establish a table or mapping function to map the sub-paths to numerical values ​​of the flow field directions.

[0081] Finally, based on the direction of the third flow field, a target bubble group and a third ultrasonic frequency matching the preset mapping relationship are obtained. The obtained target bubble group is then arranged in the target sub-cavity, and ultrasonic waves at the third ultrasonic frequency are applied to these bubble groups through an ultrasonic system. This can be achieved through precise control of the ultrasonic generator and sensors.

[0082] Optionally, in one specific implementation of this application, such as Figure 6 As shown, bubble groups 6-3 with different flow directions can be generated by arranging them in four different cavities 6-4, 6-5, 6-6, and 6-7. The bubble groups are composed of microbubbles 6-1 and 6-2 with different orientations. Driven by different ultrasonic frequencies, flow in any direction can be achieved in the microcavities.

[0083] In these alternative embodiments, flow in any direction can be achieved within microcavities by designing the layout of the bubble array and adjusting the ultrasonic frequency. This provides more flexible flow control for microfluidic systems, adapting to different practical needs. Microbubbles with different orientations can generate different flow directions, and combined with ultrasonic frequency control, highly directional microfluidic flow can be achieved. This is crucial for applications requiring precise control at the microscale. By adjusting the ultrasonic frequency and the layout of the microbubble array, real-time, flexible, and controllable adjustments to the fluid flow direction can be achieved to meet the needs of different experimental or application scenarios. Compared to other microfluidic control methods, this design may reduce system complexity, making experiments or applications easier to implement and maintain. Overall, this method of achieving flow in any direction through different combinations of ultrasonic frequencies and microbubbles brings greater flexibility and adjustability to the field of microfluidic control, contributing to improved efficiency and accuracy of microfluidic systems.

[0084] In one embodiment, the microbubble structure is formed by multiple surfaces;

[0085] At least one sub-bubble is arranged on each surface, and the sub-bubbles located on the same surface have the same opening size.

[0086] Optionally, in the embodiments of this application, such as Figure 5 As shown, by setting multiple combinations of bubbles of different sizes, 4-1, 4-2, 4-3, and 4-4 represent microbubbles with different openings. Under the control of ultrasonic signals of different frequencies, the microstructure can move controllably on a plane.

[0087] In one embodiment, the microbubble structure includes a plurality of extensions arranged circumferentially on the main body of the microbubble structure;

[0088] An extension is configured with a sub-bubble.

[0089] Optionally, in the embodiments of this application, such as Figure 7As shown, rotational motion of microstructures can be achieved by arranging microbubbles 5-1 and 5-2 with different opening sizes around the circumference and applying ultrasonic excitation signals of different frequencies.

[0090] In these alternative embodiments, rotational motion of microstructures can be achieved by employing microbubbles with different opening sizes and ultrasonic excitation frequencies. This provides an effective means for precise manipulation at the microscale. Applying ultrasonic excitation signals is a non-contact manipulation method that does not require direct contact with the microstructure, reducing interference and enabling precise control at the microscale. By changing the arrangement and excitation parameters, various motion modes of microstructures can be designed, expanding the possibilities for microstructure motion in microfluidic and micromechanical systems.

[0091] Optionally, in the embodiments of this application, three control methods are developed based on acoustically driven microbubbles. The first method generates asymmetric vortices through the interaction between microbubbles and boundaries, inducing streamline escape and generating net flow of microfluidics. The second method achieves controllable flow of microfluidics in microcavities through ultrasonic frequency control. The third method utilizes the different ratios of microcavity velocity to microvortex velocity under microfluidics generated at different ultrasonic frequencies to achieve the screening and delivery of different microloads.

[0092] Furthermore, this application can be used for the rapid, large-scale, and controllable delivery of micro- and nano-loads in microcavities; it can also be used for controllable transport in both forward and reverse directions in the field of microfluidics; it can also be used for screening loads of different particle sizes in microfluidic environments; it can also be used for delivering and maintaining the activity of active substances such as cells; it can also be used for the controllable movement of microstructures in low Reynolds number environments; and it can also be used to achieve controllable selection of different cavities in microfluidic channels.

[0093] Figure 8 A schematic diagram of a microbubble control device according to another embodiment of this application is shown. For ease of explanation, only the parts related to the embodiment of this application are shown.

[0094] Reference Figure 8 The microbubble control device is applied to a microbubble structure, which is set within a microcavity structure. Fluid flows through the microcavity structure, which is used to deliver target substances. The microbubble control device may include:

[0095] The first acquisition module 801 is used to acquire a preset first mapping relationship. The first mapping relationship includes the opening orientation of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and the correspondence between multiple flow field directions. The flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic waves applied to the microbubble structure.

[0096] The second acquisition module 802 is used to acquire a preset second mapping relationship, which includes a one-to-one correspondence between the opening sizes of multiple microbubble structures and the sizes of multiple target substances.

[0097] The third acquisition module 803 is used to acquire the target size of the target material and the target delivery location of the target material;

[0098] The delivery module 804 is used to deliver the target material to the target delivery location based on a first matching relationship between the target delivery location and a first mapping relationship, and a second matching relationship between the target size and a second mapping relationship.

[0099] In one embodiment, the delivery module 804 may include:

[0100] The first acquisition submodule is used to acquire the target opening of the microbubble structure that matches the target size from the second mapping relationship based on the target size;

[0101] The first determining submodule is used to determine the first delivery path of the target material in the microcavity structure based on the target delivery location;

[0102] The second determining submodule is used to determine the first flow field direction of the fluid based on the first delivery path;

[0103] The second acquisition submodule is used to acquire, based on the first flow field direction and the target opening, a first ultrasonic frequency that matches the first flow field direction and the first orientation of the target bubble structure from the first mapping relationship, wherein the opening size of the target bubble structure is the target opening.

[0104] The first arrangement submodule is used to arrange the target bubble structure in the microcavity structure according to a first orientation and apply ultrasonic waves of a first ultrasonic frequency to the target bubble structure to deliver the target substance to the target delivery location according to the first delivery path.

[0105] In one embodiment, the microbubble structure includes a plurality of first sub-bubbles, and the microchannel includes a plurality of first sub-channels; the delivery module 804 may further include:

[0106] The third acquisition submodule is used to obtain a first size range that matches the target size from the second mapping relationship based on the target size;

[0107] The third determining submodule is used to determine the second delivery path of the target material in each first subcavity based on the target delivery location;

[0108] The fourth determination submodule is used to determine the second flow field direction of the fluid in any one of the multiple first sub-cavities, based on the second delivery path corresponding to the cavity to be transported.

[0109] The fourth acquisition submodule is used to acquire, based on the second flow field direction and the first size range, a second ultrasonic frequency that matches the second flow field direction from the first mapping relationship, and a second orientation corresponding to multiple first target sub-bubbles, wherein the multiple first sub-bubbles include multiple first target sub-bubbles, and the opening size of each first target sub-bubble is within the first size range;

[0110] The second arrangement submodule is used to arrange each first target sub-bubble in the transport cavity according to the second orientation corresponding to each first target sub-bubble, and to apply ultrasonic waves of the second ultrasonic frequency to each first target sub-bubble so that the target material flows in the transport cavity according to the second delivery path.

[0111] In one embodiment, the microbubble structure includes multiple bubble groups, each bubble group includes multiple second sub-bubbles, and the microcavity includes multiple second sub-cavities; the delivery module 804 may further include:

[0112] The fifth acquisition submodule is used to acquire the preset third mapping relationship, which includes a one-to-one correspondence between multiple bubble groups, multiple ultrasonic frequencies, and multiple flow field directions.

[0113] The fifth determination submodule is used to determine the shortest delivery path of the target material in the multiple second sub-cavities based on the target delivery location and the arrangement positions of the multiple second sub-cavities. The shortest delivery path includes at least one target cavity, which is a flow cavity for the target material. The multiple second sub-cavities include at least one target cavity.

[0114] The sixth determination submodule is used to determine the third flow field direction of any target sub-cavity in at least one target cavity based on the sub-path corresponding to the target sub-cavity.

[0115] The sixth acquisition submodule is used to acquire, based on the third flow field direction, the target bubble group that matches the third flow field direction from the third mapping relationship, as well as the third ultrasonic frequency;

[0116] The third arrangement submodule is used to arrange the target bubble group in the target sub-cavity and apply ultrasound at a third ultrasonic frequency to the target bubble group so that the target substance flows in the target sub-cavity according to the sub-path.

[0117] In one embodiment, the microbubble structure is formed by multiple surfaces;

[0118] At least one sub-bubble is arranged on each surface, and the sub-bubbles located on the same surface have the same opening size.

[0119] In one embodiment, the microbubble structure includes a plurality of extensions arranged circumferentially on the main body of the microbubble structure;

[0120] An extension is configured with a sub-bubble.

[0121] It should be noted that the information interaction and execution process between the above-mentioned devices / units are based on the same concept as the method embodiments of this application. They are devices corresponding to the above-mentioned battery thermal runaway early warning method. All implementation methods in the above-mentioned method embodiments are applicable to the embodiments of this device. For details on its specific functions and the technical effects it brings, please refer to the method embodiment section. It will not be repeated here.

[0122] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the above-described division of functional units and modules is merely an example. In practical applications, the above functions can be assigned to different functional units and modules as needed, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above. The functional units and modules in the embodiments can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit. Furthermore, the specific names of the functional units and modules are only for easy differentiation and are not intended to limit the scope of protection of this application. The specific working process of the units and modules in the above system can be referred to the corresponding process in the foregoing method embodiments, and will not be repeated here.

[0123] Figure 9 A schematic diagram of the hardware structure of the electronic device provided in an embodiment of this application is shown.

[0124] The device may include a processor 901 and a memory 902 storing program instructions.

[0125] When processor 901 executes the program, it implements the steps in any of the above method embodiments.

[0126] For example, the program can be divided into one or more modules / units, one or more of which are stored in memory 902 and executed by processor 901 to complete this application. One or more modules / units can be a series of program instruction segments capable of performing a specific function, which describe the program's execution process in the device.

[0127] Specifically, the processor 901 may include a central processing unit (CPU), an application-specific integrated circuit (ASIC), or one or more integrated circuits that can be configured to implement the embodiments of this application.

[0128] Memory 902 may include mass storage for data or instructions. For example, and not limitingly, memory 902 may include a hard disk drive (HDD), floppy disk drive, flash memory, optical disk, magneto-optical disk, magnetic tape, or Universal Serial Bus (USB) drive, or a combination of two or more of these. Where appropriate, memory 902 may include removable or non-removable (or fixed) media. Where appropriate, memory 902 may be internal or external to the integrated gateway disaster recovery device. In a particular embodiment, memory 902 is non-volatile solid-state memory.

[0129] Memory may include read-only memory (ROM), random access memory (RAM), disk storage media devices, optical storage media devices, flash memory devices, and electrical, optical, or other physical / tangible memory storage devices. Therefore, typically, memory includes one or more tangible (non-transitory) readable storage media (e.g., memory devices) encoded with software including computer-executable instructions, and when the software is executed (e.g., by one or more processors), it is operable to perform the operations described with reference to the methods according to one aspect of this disclosure.

[0130] The processor 901 implements any of the methods described in the above embodiments by reading and executing program instructions stored in the memory 902.

[0131] In one example, the electronic device may also include a communication interface 903 and a bus 910. The processor 901, memory 902, and communication interface 903 are connected via the bus 910 and communicate with each other.

[0132] The communication interface 903 is mainly used to realize communication between various modules, devices, units and / or equipment in the embodiments of this application.

[0133] Bus 910 includes hardware, software, or both, that couples components of an online data traffic metering device together. For example, and not limitingly, the bus may include an Accelerated Graphics Port (AGP) or other graphics bus, an Enhanced Industry Standard Architecture (EISA) bus, a Front Side Bus (FSB), HyperTransport (HT) interconnect, an Industry Standard Architecture (ISA) bus, an Infinite Bandwidth Interconnect, a Low Pin Count (LPC) bus, a memory bus, a Microchannel Architecture (MCA) bus, a Peripheral Component Interconnect (PCI) bus, a PCI-Express (PCI-X) bus, a Serial Advanced Technology Attachment (SATA) bus, a Video Electronics Standards Association Local (VLB) bus, or other suitable buses, or combinations of two or more of these. Where appropriate, bus 910 may include one or more buses. Although specific buses are described and illustrated in embodiments of this application, this application contemplates any suitable bus or interconnect.

[0134] Furthermore, in conjunction with the methods in the above embodiments, this application embodiment can provide a storage medium for implementation. This storage medium stores program instructions; when these program instructions are executed by a processor, they implement any of the methods in the above embodiments.

[0135] This application also provides a chip, which includes a processor and a communication interface. The communication interface and the processor are coupled. The processor is used to run programs or instructions to implement the various processes of the above method embodiments and achieve the same technical effect. To avoid repetition, it will not be described again here.

[0136] It should be understood that the chip mentioned in the embodiments of this application may also be referred to as a system-on-a-chip, system chip, chip system, or system-on-a-chip, etc.

[0137] This application provides a computer program product, which is stored in a storage medium and executed by at least one processor to implement the various processes of the above method embodiments and achieve the same technical effects. To avoid repetition, it will not be described again here.

[0138] It should be clarified that this application is not limited to the specific configurations and processes described above and shown in the figures. For the sake of brevity, detailed descriptions of known methods are omitted here. In the above embodiments, several specific steps are described and shown as examples. However, the method process of this application is not limited to the specific steps described and shown. Those skilled in the art can make various changes, modifications, and additions, or change the order of steps, after understanding the spirit of this application.

[0139] The functional modules shown in the above block diagram can be implemented as hardware, software, firmware, or a combination thereof. When implemented in hardware, they can be, for example, electronic circuits, application-specific integrated circuits (ASICs), appropriate firmware, plug-ins, function cards, etc. When implemented in software, the elements of this application are programs or code segments used to perform the required tasks. Programs or code segments can be stored on machine-readable media or transmitted over a transmission medium or communication link via data signals carried on a carrier wave. "Machine-readable media" can include any medium capable of storing or transmitting information. Examples of machine-readable media include electronic circuits, semiconductor memory devices, ROM, flash memory, erasable ROM (EROM), floppy disks, CD-ROMs, optical disks, hard disks, fiber optic media, radio frequency (RF) links, etc. Code segments can be downloaded via computer grids such as the Internet, intranets, etc.

[0140] It should also be noted that the exemplary embodiments mentioned in this application describe methods or systems based on a series of steps or apparatus. However, this application is not limited to the order of the above steps; that is, the steps can be performed in the order mentioned in the embodiments, or in a different order, or several steps can be performed simultaneously.

[0141] The aspects of this disclosure have been described above with reference to flowchart illustrations and / or block diagrams of methods, apparatus (systems), and program products according to embodiments of this disclosure. It should be understood that each block in the flowchart illustrations and / or block diagrams, and combinations of blocks in the flowchart illustrations and / or block diagrams, can be implemented by computer program instructions. These program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to create a machine such that these instructions, executable via the processor of the computer or other programmable data processing apparatus, enable the implementation of the functions / actions specified in one or more blocks of the flowchart illustrations and / or block diagrams. Such a processor can be, but is not limited to, a general-purpose processor, a special-purpose processor, a special application processor, or a field-programmable logic circuit. It is also understood that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can also be implemented by special-purpose hardware performing the specified functions or actions, or can be implemented by a combination of special-purpose hardware and computer instructions.

[0142] The above are merely specific embodiments of this application. Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the specific working processes of the systems, modules, and units described above can be referred to the corresponding processes in the foregoing method embodiments, and will not be repeated here. It should be understood that the protection scope of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the protection scope of this application.

Claims

1. A microbubble control method characterized by, The method is applied to a micro-bubble structure, the micro-bubble structure is arranged in a micro-canal structure, a fluid flows in the micro-canal structure, and the micro-bubble structure is used for delivering a target substance, and the method comprises the following steps: obtaining a preset first mapping relationship, the first mapping relationship comprising a corresponding relationship between a plurality of opening orientations of the micro-bubble structure, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions, the flow field direction being a flow direction of the fluid, and the ultrasonic frequency being a frequency of ultrasonic waves applied to the micro-bubble structure; obtaining a preset second mapping relationship, the second mapping relationship comprising a one-to-one corresponding relationship between a plurality of opening sizes of the micro-bubble structure and a plurality of size sizes of the target substance; obtaining a target size of the target substance and a target delivery position of the target substance; delivering the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship.

2. The method of claim 1, wherein, The delivering of the target substance to the target delivery position based on the first matching relationship between the target delivery position and the first mapping relationship and the second matching relationship between the target size and the second mapping relationship comprises: obtaining a target opening of the micro-bubble structure matched with the target size from the second mapping relationship based on the target size; determining a first delivery path of the target substance in the micro-canal structure based on the target delivery position; determining a first flow field direction of the fluid based on the first delivery path; obtaining a first ultrasonic frequency matched with the first flow field direction and a first orientation of a target bubble structure from the first mapping relationship based on the first flow field direction and the target opening, the opening size of the target bubble structure being the target opening; arranging the target bubble structure in the first orientation in the micro-canal structure and applying ultrasonic waves of the first ultrasonic frequency to the target bubble structure to deliver the target substance to the target delivery position along the first delivery path.

3. The method of claim 1, wherein, The micro-bubble structure comprises a plurality of first sub-bubbles, and the micro-canal comprises a plurality of first sub-canals. The delivering of the target substance to the target delivery position based on the first matching relationship between the target delivery position and the first mapping relationship and the second matching relationship between the target size and the second mapping relationship further comprises: obtaining a first size range matched with the target size from the second mapping relationship based on the target size; determining a second delivery path of the target substance in each first sub-canal based on the target delivery position; determining a second flow field direction of the fluid in any one of the plurality of first sub-canals to be transported based on the corresponding second delivery path of the to-be-transported canal. obtain, based on the second flow field direction and the first size range, a second ultrasonic frequency matched with the second flow field direction and a second orientation corresponding to a plurality of first target sub-bubbles from the first mapping relationship, the plurality of first sub-bubbles including the plurality of first target sub-bubbles, and an opening size of each first target sub-bubble being within the first size range; arrange each first target sub-bubble in the to-be-transported cavity according to the second orientation corresponding to each first target sub-bubble, and apply an ultrasonic wave of the second ultrasonic frequency to each first target sub-bubble, so that the target substance flows in the to-be-transported cavity according to the second delivery path.

4. The method of claim 1, wherein, The micro-bubble structure includes a plurality of bubble groups, each bubble group including a plurality of second sub-bubbles, and the micro-cavity includes a plurality of second sub-cavities; The method further includes: obtain a preset third mapping relationship, the third mapping relationship including a one-to-one correspondence relationship between the plurality of bubble groups, a plurality of ultrasonic frequencies, and a plurality of flow field directions; determine, based on the target delivery position and arrangement positions of the plurality of second sub-cavities, a shortest delivery path of the target substance in the plurality of second sub-cavities, the shortest delivery path including at least one target cavity, the target cavity being a flow cavity of the target substance, and the plurality of second sub-cavities including the at least one target cavity; for any one target sub-cavity in the at least one target cavity, determine a third flow field direction of the target sub-cavity based on a sub-path corresponding to the target sub-cavity; obtain, based on the third flow field direction, a target bubble group matched with the third flow field direction and a third ultrasonic frequency from the third mapping relationship; arrange the target bubble group in the target sub-cavity, and apply an ultrasonic wave of the third ultrasonic frequency to the target bubble group, so that the target substance flows in the target sub-cavity according to the sub-path.

5. The method of claim 3, wherein, The micro-bubble structure is enclosed by a plurality of surfaces; each surface is arranged with at least one sub-bubble, and sub-bubbles located on the same surface have the same opening size.

6. The method of claim 3, wherein, The micro-bubble structure includes a plurality of extensions arranged circumferentially on a main body of the micro-bubble structure; one extension is provided with one sub-bubble.

7. A microbubble control device, characterized by, The device is applied to a micro-bubble structure arranged in a micro-cavity structure, a fluid flows in the micro-cavity structure, and the micro-bubble structure is used to deliver a target substance, and the device includes: a first obtaining module configured to obtain a preset first mapping relationship, the first mapping relationship including a correspondence relationship between a plurality of opening orientations of the micro-bubble structure, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions, the flow field direction being a flow direction of the fluid, and the ultrasonic frequency being a frequency of an ultrasonic wave applied to the micro-bubble structure; The second obtaining module is configured to obtain a preset second mapping relationship, the second mapping relationship comprising a one-to-one correspondence between opening sizes of a plurality of microbubble structures and size sizes of a plurality of target substances; The third obtaining module is configured to obtain a target size of the target substance and a target delivery position of the target substance; The delivery module is configured to deliver the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship.

8. An electronic device, comprising: The device comprises a processor and a memory storing computer program instructions; The processor executes the computer program instructions to implement the microbubble control method according to any one of claims 1-6.

9. A computer-readable storage medium, characterized in that, The computer readable storage medium stores computer program instructions, and the computer program instructions are executed by the processor to implement the microbubble control method according to any one of claims 1-6.

10. A computer program product, characterised in that, The instructions in the computer program product are executed by the processor of the electronic device to enable the electronic device to perform the microbubble control method according to any one of claims 1-6.

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