A left atrial appendage closure device

Abstract

This invention discloses a left atrial appendage closure device, belonging to the field of medical devices. The left atrial appendage closure device of this invention includes a delivery catheter, a support tube, a support plate, a telescopic support rod, a closure clamp assembly, and a control cable. The closure clamp is inserted into the opening of the left atrial appendage via the delivery catheter and is opened at the opening of the left atrial appendage through the cooperation of the telescopic support rod and the control cable. A puncture hook inside the closure clamp pierces the tissue wall of the left atrial appendage opening to achieve closure. Finally, the closure clamp closes the left atrial appendage opening using a straight "I" closure mechanism. Compared with existing left atrial appendage occluders, the puncture hook on the outer periphery of the closure clamp can radially pierce the tissue, and the closure clamp drives the closure of the left atrial appendage opening, making the connection between the closure clamp and the left atrial appendage more secure and less prone to detachment. It also eliminates the problem of decreased reliability of the left atrial appendage seal due to loosening or movement, ensuring the long-term effectiveness of left atrial appendage closure and reducing complications caused by detachment and unreliable sealing.

Description

Technical Field

[0001] This invention relates to a medical device, and more specifically, to a left atrial appendage closure device, primarily used for closing and occluding the left atrial appendage. Background Technology

[0002] The atrial appendage is a projection of the atria of the human heart, divided into the right and left atrial appendages. The right atrial appendage is adjacent to the ascending aorta, while the left atrial appendage is located next to the pulmonary trunk. The left atrial appendage is a common source of thrombi, which can lead to stroke, especially in patients with atrial fibrillation. To prevent stroke in atrial fibrillation, closure of the left atrial appendage is an effective treatment. Currently, the main techniques for closure of the left atrial appendage are surgical left atrial appendage resection and transcatheter left atrial appendage occlusion. Surgical resection of the left atrial appendage has disadvantages such as large trauma and many complications and is no longer widely used; transcatheter left atrial appendage occlusion is a minimally invasive treatment and has become the main method for closing the left atrial appendage, and has been greatly developed, with many medical devices for left atrial appendage occlusion emerging.

[0003] For example, Chinese Patent Publication No. CN1342056A, entitled "Device for Preventing Embolizing Material from Passing Through the Left Atrial Appendage of a Patient" (publication date: March 27, 2002), has an expandable body with an outer periphery, the size and structure of which are made to engage the surface of the patient's left atrial appendage when expanded, and a barrier layer disposed on the expandable body to prevent embolic material from passing through the left atrial appendage. Similar left atrial appendage occlusion devices include: "Left Atrial Appendage Occlusion Device" disclosed in Chinese Patent Publication No. CN102805654A (publication date: December 5, 2012), "Occlusion Device and Related Deployment Method" disclosed in Chinese Patent Publication No. CN103607962A (publication date: February 26, 2014), "Double Umbrella Type Left Atrial Appendage Closure Device" disclosed in Chinese Patent Publication No. CN104107072A (publication date: October 22, 2014), and "Left Atrial Appendage Occlusion Device" disclosed in Chinese Patent Publication No. CN106923883A (publication date: July 7, 2017), etc. The aforementioned left atrial appendage occlusion devices mainly use sealing elements to block the neck of the left atrial appendage and use barbs and other structures to prevent the sealing elements from falling off. During implantation, they can be inserted percutaneously and delivered to the left atrial appendage opening through a catheter, and then implanted and occluded. They have the advantages of short operation time and high success rate.

[0004] Although the aforementioned left atrial appendage occlusion devices are widely used clinically, occluder dislodgement remains one of the most serious complications. Dislodgement is primarily caused by a mismatch between the occluder's size and the patient's left atrial appendage size, preventing the barbs on the occluder from effectively embedding into the tissue for fixation. Furthermore, it is currently difficult to customize occluders according to the specific left atrial appendage size of each patient. Additionally, the sealing portion of most existing left atrial appendage occluders is essentially a cap or plug at the neck opening of the left atrial appendage. Over time, if the occluder shifts or loosens, the sealing reliability can decrease, affecting the long-term effectiveness of the occluder. Summary of the Invention

[0005] 1. The technical problem that the invention aims to solve

[0006] The purpose of this invention is to overcome the aforementioned shortcomings of existing left atrial appendage occlusion devices and provide a left atrial appendage closure device. Using the technical solution of this invention, a closure clip is used to close the left atrial appendage, replacing previous left atrial appendage occlusion techniques, thus ensuring the reliability and long-term effectiveness of left atrial appendage closure. Specifically, the closure clip is inserted into the opening of the left atrial appendage using a delivery catheter in a closed state. It is then opened at the left atrial appendage opening by the cooperation of a telescopic support rod and a control cable. A puncture hook inside the closure clip pierces the tissue wall of the left atrial appendage opening to achieve contact. Finally, the "I"-shaped closure of the closure clip closes the left atrial appendage opening. Compared with existing left atrial appendage occlusion devices, the puncture hook on the outer periphery of the closure clip can radially pierce the tissue, and the closure of the clip drives the closure of the left atrial appendage opening. This makes the connection between the closure clip and the left atrial appendage more secure and less prone to detachment. It also eliminates the problem of decreased reliability of the left atrial appendage seal due to loosening or movement, ensuring the long-term effectiveness of left atrial appendage closure and reducing complications caused by detachment and unreliable sealing.

[0007] 2. Technical Solution

[0008] To achieve the above objectives, the technical solution provided by this invention is as follows:

[0009] A left atrial appendage closure device of the present invention includes

[0010] A delivery conduit, with a sleeve at its front end;

[0011] A support tube, which is inserted inside the delivery conduit, is used to guide the delivery conduit into the designated position.

[0012] The support plate is installed at the front end of the support tube and has several connecting seats distributed circumferentially.

[0013] The telescopic support rod has one end mounted on the corresponding connecting seat of the support plate via a rotating seat. Each of the telescopic support rods has a retracted state that converges towards the center and an extended state that radiates radially relative to the support plate. The retracted state and the extended state can be switched by rotating the telescopic support rod. Each of the telescopic support rods also has a locking assembly for keeping the telescopic support rod in the stretched state and for triggering unlocking to retract the telescopic support rod.

[0014] The closing clamp assembly includes a tubular closing ring, within which a pullable needle bar is installed. The needle bar has several piercing hooks, and the outer side of the closing ring has several hook extrusion holes corresponding to the positions of the piercing hooks. The closing ring also has an interlocking assembly for maintaining the closing ring in a straight-line closed state. The closed ring in the closed state and the telescopic support rod in the retracted state are housed in the aforementioned sleeve and can be pushed forward by the support tube.

[0015] The control cable includes a closure clamp opening / closing cable, a hook cable, and a locking cable located within the support tube. The front end of the closure clamp opening / closing cable passes through the corresponding telescopic support rod and connects to the closure ring. It is used to tighten the corresponding closure clamp opening / closing cable to align the free end of the corresponding telescopic support rod with the closure ring, and to open the closure ring when the telescopic support rod is in the unfolded state. The closure clamp opening / closing cable can also cooperate with the retraction of the telescopic support rod after the locking assembly is unlocked to control the closure ring to close in an "I"-shaped closed state. The front end of the hook cable passes through the support plate and connects to the needle bar inside the closure ring. It is used to pull the needle bar when the closure ring is in the unfolded state to cause the piercing hook to pierce the corresponding hook extrusion hole. The front end of the locking cable is connected to the interlocking assembly on the closure ring and is used to control the interlocking assembly to engage or disengage via the locking cable.

[0016] Furthermore, the delivery conduit also includes a thiocyanate tube, with the sleeve installed at the front end of the thiocyanate tube.

[0017] Furthermore, the support plate is provided with a core rod mounting hole at its center, and a core rod capable of axial movement is provided in the core rod mounting hole. The tail of the core rod is connected to a core rod push-pull rod. The core rod also has a first cable outlet hole and a second cable outlet hole that penetrates its front end face. The hook pull line passes through the first cable outlet hole, and the lock pull line passes through the second cable outlet hole.

[0018] Furthermore, two needle bars are centrally symmetrically arranged within the closed loop. The outer side of the closed loop has two oppositely arranged needle bar mounting holes. The needle bars are installed within the closed loop through the corresponding needle bar mounting holes along the direction of the piercing hook. The inner side of the closed loop also has hook pull holes opposite to the positions of the aforementioned needle bar mounting holes. The hook pull line is connected to one end of the corresponding needle bar through the corresponding hook pull hole, and is used to pull the needle bar to move in the opposite direction of the piercing hook so that the piercing hook punctures the corresponding hook extrusion hole.

[0019] Furthermore, the inner side of the closed loop is also provided with several support rod connection holes. The closing clamp opening and closing pull wires pass through the corresponding telescopic support rods and are connected to the corresponding support rod connection holes. After the closed loop in the closed state and the telescopic support rod in the retracted state are pushed out of the sleeve, the direction of the closed loop is controlled by pulling the two closing clamp opening and closing pull wires located in the middle of the closed loop in the closed state.

[0020] Furthermore, the interlocking assembly includes an upper latch and a lower latch that can interlock with each other. The upper latch and the lower latch are respectively located on the closed loop and at the middle position of the corresponding needle bar. Each of the upper latch and the lower latch is connected to a latch pull line. The latches are engaged or disengaged by pulling the latch pull line to deform them.

[0021] Furthermore, the telescopic support rod has at least two interlocking support tubes, with a locking assembly between adjacent support tubes. The locking assembly includes several circumferentially distributed locking blocks, each locking block being held together by a hoop. The hoop is located at the tail end of the inner support tube. Each locking block has an inner conical surface forming a conical hole on its inner side. The end of each locking block extending beyond the tail end of the support tube has a locking flange extending outward. The inner side of the front end of the outer support tube, away from the wall, has a locking groove that can cooperate with the locking flange. The end of each locking block away from the locking flange is connected by a spring. The rings are connected inwards, so that each locking block has an elastic tendency to expand outwards due to rotation around the ring; when each of the support tubes is in a stretched state, the locking flange is engaged in the corresponding locking groove; the telescopic support rod also has an unlocking trigger rod that can be axially pressed, the tail end of the unlocking trigger rod has a pressing part, and the front end has a trigger part that cooperates with the inner conical surface of each locking block. By axially pressing the unlocking trigger rod, the trigger part is driven to extend into the conical hole formed by each locking block, causing each locking block to rotate around the ring, causing the locking flange to disengage from the locking groove and unlock.

[0022] Furthermore, the unlocking trigger rod is located inside the support tube closest to the support plate in the telescopic support rod. The tail end of the support tube is provided with a tail sleeve and a return spring. The unlocking trigger rod passes through the tail sleeve, and the return spring is sleeved on the unlocking trigger rod. One end of the return spring acts on the tail sleeve, and the other end acts on the pressing part, which is used to drive the unlocking trigger rod to reset after being pressed.

[0023] Furthermore, the support plate is also provided with 90° guide holes corresponding to the positions of each telescopic support rod. The radial opening of each 90° guide hole is opposite to the tail end of the telescopic support rod in the unfolded state. The support tube has an unlocking operation rod, and the front end of the unlocking operation rod has a flexible pressing section. The flexible pressing section passes through the corresponding 90° guide hole. The pressing movement of the unlocking operation rod drives each flexible pressing section to extend out of the radial hole of the 90° guide hole and drive the corresponding unlocking trigger rod to perform the pressing unlocking action.

[0024] Furthermore, the connecting seat has short shafts on both sides, the rotating seat has a rotating shaft hole that rotatably engages with the short shafts, and the connecting seat also has an axial hole that runs vertically through the connecting seat. The axial hole intersects with the 90° guide hole, and the upper side of the connecting seat has a wire groove that connects the axial hole and the corresponding radial hole. When the telescopic support rod switches from the retracted state to the extended state, the closing clamp pull wire passing through the axial hole passes through the wire groove and enters the radial hole.

[0025] 3. Beneficial effects

[0026] Compared with existing known technologies, the technical solution provided by this invention has the following significant advantages:

[0027] (1) The present invention provides a left atrial appendage closure device, which uses a closure clamp to close the left atrial appendage instead of the previous left atrial appendage occlusion technology, thus ensuring the reliability and long-term effectiveness of left atrial appendage closure. Specifically, it includes a delivery catheter, a support tube, a support plate, a telescopic support rod, a closure clamp assembly, and a control cable. The closure clamp can be inserted into the opening of the left atrial appendage in a closed state using the delivery catheter, and then opened at the opening of the left atrial appendage through the cooperation of the telescopic support rod and the control cable. The puncture hook inside the closure clamp is used to pierce the tissue wall of the opening of the left atrial appendage to achieve the connection. Finally, the closure clamp is used to close the opening of the left atrial appendage by closing the "I" shape. Compared with the existing left atrial appendage occlusion device, the puncture hook on the outer periphery of the closure clamp can pierce the tissue radially and use the closure clamp to drive the opening of the left atrial appendage to close, making the connection between the closure clamp and the left atrial appendage more secure and less likely to fall off. At the same time, there is no problem of reduced reliability of the left atrial appendage seal due to loosening or movement, thus ensuring the long-term effectiveness of left atrial appendage closure and reducing complications caused by falling off and unreliable sealing.

[0028] (2) A left atrial appendage closure device of the present invention uses a support tube and a control pull line to operate the entire left atrial appendage closure device. Different operation actions are achieved by using the closure clamp opening and closing pull line, the hook pull line, and the locking pull line, making the left atrial appendage closure operation simple, convenient, flexible and easy to control.

[0029] (3) A left atrial appendage closure device of the present invention has a delivery catheter including a hysterosalpingography tube and a cannula. The cannula is installed at the front end of the hysterosalpingography tube. The closure device can be flexibly and accurately delivered to the designated position using the hysterosalpingography tube. The control precision is high, and the surgical trauma is small, safe and reliable.

[0030] (4) A left atrial appendage closure device of the present invention has a core rod mounting hole at the center of its support plate. A core rod capable of axial movement is provided in the core rod mounting hole. A core rod push-pull rod is connected to the tail end of the core rod. The core rod also has a first wire outlet hole and a second wire outlet hole that penetrates its front end face. The hook pull line is passed through the first wire outlet hole and the lock pull line is passed through the second wire outlet hole. The wire outlet position can be adjusted by using the core rod, which facilitates the control of the force direction of the pull line, thereby ensuring the flexibility and labor-saving operation of the pull line and improving the accuracy of the closure clamp in the left atrial appendage closure operation.

[0031] (5) A left atrial appendage closure device of the present invention has two needle rods arranged symmetrically in the center of the closure ring. The outer side of the closure ring has two oppositely arranged needle rod mounting holes. The needle rods are installed in the closure ring along the direction of the puncture hook through the corresponding needle rod mounting holes. With the above design, on the one hand, it is convenient to assemble the needle rods. On the other hand, the needle rods can be used to improve the strength of both sides of the closure ring, so that the closure ring can bend and close naturally at the weak area where the needle rod mounting holes are located when closing, thereby improving the closure tightness of the closure clamp. In addition, the inner side of the closure ring also has a hook pull line hole opposite to the position of the needle rod mounting holes. The hook pull line is connected to one end of the corresponding needle rod through the corresponding hook pull line hole, and is used to pull the needle rod to move in the opposite direction of the puncture hook so that the puncture hook pierces the corresponding hook extrusion hole. This makes the pulling operation of the needle rod simple and convenient, and can stably realize the extension of the puncture hook and firmly pierce the tissue, ensuring the firmness of the combination between the closure ring and the left atrial appendage tissue wall.

[0032] (6) A left atrial appendage closure device of the present invention has several support rod connection holes distributed on the inner side of the closure ring. The closure clamp opening and closing pull wires pass through the corresponding telescopic support rods and are connected to the corresponding support rod connection holes, so that the free end of the telescopic support rod is stably connected with the closure ring, and the closure ring is stably opened. Furthermore, after the closure ring in the closed state and the telescopic support rod in the retracted state are pushed out of the cannula, the direction of the closure ring is controlled by pulling the two closure clamp opening and closing pull wires located in the middle of the closure ring in the closed state. This makes it easy to adjust the relative position of the closure ring with the left atrial appendage opening by controlling the direction of the closure ring, and ensure the implantation accuracy of the closure ring.

[0033] (7) A left atrial appendage closure device of the present invention includes an interlocking assembly comprising an upper locking buckle and a lower locking buckle that can be interlocked with each other. The upper locking buckle and the lower locking buckle are respectively disposed on the closure ring and located in the middle of the corresponding needle bar. The upper locking buckle and the lower locking buckle are each connected to a locking buckle pull line. The upper locking buckle and the lower locking buckle are deformed by pulling the locking buckle pull line to lock or disengage. The interlocking assembly with mechanical interlocking structure has a locking direction that is the closing deformation direction of the closure ring, so that the closure ring is locked firmly and reliably when closed and is not easy to loosen. Moreover, the pulling direction of the locking buckle pull line on the upper and lower locking buckles is the vertical direction of the closure ring, which can easily realize the locking or disengagement control of the upper and lower locking buckles.

[0034] (8) A left atrial appendage closure device of the present invention has a telescopic support rod having at least two interlocking support tubes, and a locking assembly between adjacent support tubes, which can ensure the stability of the telescopic support rod in the stretched state, and facilitate the use of the telescopic support rod to support the closure ring to keep it in a circular and open state; at the same time, the locking assembly can be unlocked by pressing to retract the telescopic support rod, which facilitates the closure ring to close into a "I" shape, and has good operational stability; in addition, the above-mentioned locking assembly has a simple and compact structure design, which can be installed in a small-diameter telescopic support rod; and the structure is ingeniously designed, and the multi-level locking assembly can be unlocked by pressing the unlocking trigger rod, which is convenient to operate;

[0035] (9) A left atrial appendage closure device of the present invention has an unlocking trigger rod located in the support tube closest to the support plate in the telescopic support rod. The tail end of the support tube is provided with a tail sleeve and a return spring. The unlocking trigger rod passes through the tail sleeve, and the return spring is sleeved on the unlocking trigger rod. One end of the return spring acts on the tail sleeve, and the other end acts on the pressing part, which is used to drive the unlocking trigger rod to reset after pressing. The unlocking trigger rod has good pressing feedback performance, which further improves the convenience of surgical operation.

[0036] (10) A left atrial appendage closure device of the present invention has a support plate with 90° guide holes corresponding to the positions of each telescopic support rod. The radial opening of each 90° guide hole is opposite to the tail end of the telescopic support rod in the unfolded state. The support tube has an unlocking operation rod. The front end of the unlocking operation rod has a flexible pressing section. The flexible pressing section passes through the corresponding 90° guide hole. The pressing movement of the unlocking operation rod drives each flexible pressing section to extend out from the radial hole of the 90° guide hole and drive the corresponding unlocking trigger rod to perform the pressing unlocking action. The unlocking operation rod is used to facilitate the unlocking operation of the telescopic support rod from the outside. It has the advantages of simple structure and convenient operation. Attached Figure Description

[0037] Figure 1 This is a schematic diagram of the overall assembly of a left atrial appendage closure device according to the present invention;

[0038] Figure 2 This is a schematic diagram of the combined state of a left atrial appendage closure device according to the present invention (delivery catheter omitted);

[0039] Figure 3 This is a schematic diagram of the anterior component of a left atrial appendage closure device according to the present invention;

[0040] Figure 4 This is a schematic diagram of the assembly structure of the support plate and each telescopic support rod in this invention;

[0041] Figure 5 This is a cross-sectional view of the telescopic support rod in the retracted state on the support plate in this invention.

[0042] Figure 6 This is a three-dimensional structural diagram of the support disk in this invention;

[0043] Figure 7 This is a schematic diagram of the telescopic support rod in the tensile state of the present invention;

[0044] Figure 8 for Figure 7 Schematic diagram of the cross-sectional structure along the AA direction;

[0045] Figure 9 for Figure 8 A magnified schematic diagram of the local structure at point K;

[0046] Figure 10 This is a schematic diagram of the retracted state structure of the telescopic support rod in this invention;

[0047] Figure 11 for Figure 10 Schematic diagram of the cross-sectional structure in the middle BB direction;

[0048] Figure 12 This is a schematic diagram (top view) showing the disassembled structure of the locking assembly and the adjacent support tube in this invention;

[0049] Figure 13 This is a schematic diagram of the disassembled structure of the locking assembly and the adjacent support tube in this invention (view from below);

[0050] Figure 14 This is a schematic diagram of the closing clamp assembly in its initial closed state in this invention;

[0051] Figure 15 This is a schematic diagram of the closed clamp assembly in the closed state of the present invention (the piercing hook needle is protruding);

[0052] Figure 16 This is a schematic diagram of the needle shaft and the puncture hook on it in this invention;

[0053] Figure 17This is a schematic diagram of the closed clamp assembly in the open state in this invention;

[0054] Figure 18 This is a cross-sectional view of the telescopic support rod in the extended state on the support plate in this invention.

[0055] Figure 19 This is a schematic diagram of the operation of a left atrial appendage closure device of the present invention in the closed clamp open state.

[0056] Explanation of the labels in the diagram:

[0057] 1. Delivery conduit; 1a. Hypophthalmic tube; 1b. Sleeve; 2. Support tube; 3. Support plate; 3-1. Connecting seat; 3-1a. Short shaft; 3-1b. Axial hole; 3-1c. Radial hole; 3-1d. Wire groove; 3-2. Pull wire hole; 3-3. Core rod mounting hole; 3-4. 90° guide hole; 4. Telescopic support rod; 4a. Rotating seat; 4a-1. Rotating shaft hole; 4-1. First support tube; 4-2. Second support tube; 4-3. Third support tube; 4-4. Unlocking trigger rod; 4-4a. Pressing part; 4-4b. Trigger part; 4-5. Tail sleeve; 4-6. Return spring; 4-7. Locking assembly; 4-7-1. Locking block; 4-7-1a. 4-7-1b, Locking flange; 4-7-2, Hoop ring; 4-7-3, Elastic ring; 4-8, Locking groove; 4-9, Ring groove; 5, Core rod; 5a, First cable outlet hole; 5b, Second cable outlet hole; 6, Closing clamp assembly; 6-1, Closing ring; 6-1a, Needle bar mounting hole; 6-1b, Hook needle pull hole; 6-1c, Hook needle extrusion hole; 6-1d, Support rod connecting hole; 6-2, Needle bar; 6-2a, Puncture hook; 6-3, Upper locking buckle; 6-4, Lower locking buckle; 7, Control pull line; 7a, Closing clamp opening and closing pull line; 7b, Hook needle pull line; 7c, Locking buckle pull line; 8, Core rod push-pull rod; 9, Unlocking operation rod; 9-1, Flexible pressing section. Detailed Implementation

[0058] To further understand the content of this invention, a detailed description of the invention will be provided in conjunction with the accompanying drawings and embodiments.

[0059] [Example]

[0060] This embodiment provides a left atrial appendage closure device, primarily used to close the opening of the left atrial appendage to eliminate the source of thrombus formation. Combined with... Figure 1 , Figure 2 and Figure 3 As shown, the left atrial appendage closure device mainly includes a delivery catheter 1, a support tube 2, a support plate 3, a telescopic support rod 4, a closure clamp assembly 6, and a control cable 7, wherein:

[0061] The delivery catheter 1 is used to penetrate the tissue via a trocar to establish a channel for delivering other instruments to a designated location (left atrial appendage). Its distal end has a cannula 1b for receiving the anterior component of the left atrial appendage closure device (see reference). Figure 1 (as shown);

[0062] The support tube 2 is inserted into the delivery catheter 1 and is used to guide the delivery catheter 1 to the designated position; the support tube 2 can control the forward and backward movement of the front component and adjust the implantation position.

[0063] The support plate 3 is installed at the front end of the support tube 2, and several connecting seats 3-1 are distributed around it; the connecting seats 3-1 are preferably evenly distributed on the support plate 3, with 8 to 12 being more preferred.

[0064] One end of the telescopic support rod 4 is mounted on the corresponding connecting seat 3-1 of the support plate 3 via a rotating seat 4a. Each telescopic support rod 4 has a retracted state (converging towards the center) and an extended state (radiating outwards) relative to the support plate 3. The retracted and extended states can be switched by rotating the telescopic support rod 4. In the retracted state, the telescopic support rods 4 are gathered together and can be stored in the sleeve 1b. In the extended state, the telescopic support rods 4 are approximately perpendicular to the support tube 2. Each telescopic support rod 4 can be extended to form a radial structure to open the closing clamp assembly 6. In addition, each telescopic support rod 4 also has a locking assembly 4-7 for keeping the telescopic support rod 4 in the stretched state and for triggering unlocking to retract the telescopic support rod 4. When the locking assembly 4-7 is locked, the telescopic support rod 4 is kept in the stretched state and cannot retract. Only after the locking assembly 4-7 is unlocked can the telescopic support rod 4 retract. Figures 1 to 3 As shown, in the initial state, each telescopic support rod 4 is kept in a stretched state under the action of the locking assembly 4-7;

[0065] The closure clamp assembly 6 is used to close the left atrial appendage orifice. It includes a tubular closure ring 6-1, within which a pullable needle bar 6-2 is installed. The needle bar 6-2 has several puncture hooks 6-2a. The outer side of the closure ring 6-1 has several hook extrusion holes 6-1c corresponding to the positions of the puncture hooks 6-2a. After the puncture hooks 6-2a pass through the closure ring 6-1, they form a hook structure (e.g., ...). Figure 15 (As shown), thus connecting the closing ring 6-1 to the tissue wall of the left atrial appendage; the closing ring 6-1 also has an interlocking component for keeping the closing ring 6-1 in a "I"-shaped closed state, so that the originally open neck of the left atrial appendage can be closed into a "I"-shaped slit under the action of the closing ring 6-1, thereby realizing the closure of the left atrial appendage; the closed ring 6-1 in the closed state and the telescopic support rod 4 in the retracted state are housed in the aforementioned sleeve 1b (as shown). Figure 1As shown), and can push the sleeve 1b forward under the action of the support tube 2; after the closed loop 6-1 in the closed state and the telescopic support rod 4 in the retracted state are pushed out from the sleeve 1b, the closed loop 6-1 and the telescopic support rod 4, which are no longer constrained by the sleeve 1b, can be unfolded by controlling the pull wire 7.

[0066] The control cable 7 includes a closure clamp opening / closing cable 7a, a hook cable 7b, and a locking cable 7c located within the support tube 2. The front end of the closure clamp opening / closing cable 7a passes through the corresponding telescopic support rod 4 and connects to the closing ring 6-1. It is used to tighten the corresponding closure clamp opening / closing cable 7a to align the free end of the corresponding telescopic support rod 4 with the closing ring 6-1, and to open the closing ring 6-1 when the telescopic support rod 4 is in the unfolded state. The closure clamp opening / closing cable 7a can also be used in the aforementioned locking assembly 4- 7. After unlocking, the retraction of the telescopic support rod 4 is used to control the closure ring 6-1 to close in an "I"-shaped closed state; the front end of the hook pull line 7b passes through the support plate 3 and is connected to the needle bar 6-2 inside the closure ring 6-1, which is used to pull the needle bar 6-2 when the closure ring 6-1 is in an open state so that the piercing hook 6-2a pierces the corresponding hook extrusion hole 6-1c; the front end of the locking pull line 7c is connected to the interlocking component on the closure ring 6-1, which is used to control the interlocking component to engage or disengage through the locking pull line 7c.

[0067] Based on the aforementioned left atrial appendage closure device, the closure clamp can replace previous left atrial appendage occlusion techniques, ensuring the reliability and long-term effectiveness of left atrial appendage closure. Specifically, the closure clamp is inserted into the opening of the left atrial appendage using the delivery catheter 1 in a closed state. It is then opened at the left atrial appendage opening by the cooperation of the telescopic support rod 4 and the control cable 7. The puncture hook 6-2a inside the closure clamp pierces the tissue wall of the left atrial appendage opening to achieve contact. Finally, the closure clamp's "I"-shaped closure achieves closure of the left atrial appendage opening. Compared to existing left atrial appendage occlusion devices, the puncture hook 6-2a on the outer periphery of the closure clamp can radially pierce the tissue, and the closure clamp's closure drives the left atrial appendage opening to close. This makes the connection between the closure clamp and the left atrial appendage more secure and less prone to dislodgement. It also eliminates the problem of decreased left atrial appendage sealing reliability due to loosening or movement, ensuring the long-term effectiveness of left atrial appendage closure and reducing complications caused by dislodgement and unreliable sealing. In addition, the entire left atrial appendage closure device is operated using the support tube 2 and the control pull line 7. Different operating actions are achieved by using the closure clamp opening and closing pull line 7a, the hook pull line 7b, and the locking pull line 7c, making the left atrial appendage closure operation simple, convenient, flexible, and easy to control.

[0068] like Figure 1As shown, in this embodiment, the delivery catheter 1 also includes a hypotube 1a, and a cannula 1b is installed at the front end of the hypotube 1a. The hypotube 1a is an existing product that can shuttle within blood vessels and has excellent controllability. The direction control of the hypotube 1a can also be achieved by using a pull wire. Using the hypotube 1a, the closure device can be flexibly and accurately delivered to the designated position, with high control precision, minimal surgical trauma, and safety and reliability.

[0069] Reference Figures 4 to 6 As shown, in this embodiment, the support plate 3 is further provided with a core rod mounting hole 3-3 at its center, and a core rod 5 capable of axial movement (e.g., ...) is provided in the core rod mounting hole 3-3. Figures 1 to 3 The tail of the core rod 5 is connected to a core rod push-pull rod 8. The core rod 5 also has a first outlet hole 5a and a second outlet hole 5b extending through its front end. The hook pull line 7b passes through the first outlet hole 5a, and the locking pull line 7c passes through the second outlet hole 5b. The core rod 5 allows adjustment of the pull line's exit position, facilitating control of the pull line's force direction, thus ensuring operational flexibility and ease of use, and improving the accuracy of the closure clamp's left atrial appendage closure operation. The movement of the core rod 5 is controlled by the core rod push-pull rod 8. It should be understood that both the support tube 2 and the core rod push-pull rod 8 are made of flexible material, allowing for bending along with the thiophanate-methyl tube 1a, facilitating guidance and operation within the patient's body.

[0070] like Figures 14 to 16As shown, in this embodiment, preferably, two needle bars 6-2 are centrally symmetrically arranged within the closed ring 6-1. The outer side of the closed ring 6-1 has two oppositely arranged needle bar mounting holes 6-1a. The needle bars 6-2 are installed within the closed ring 6-1 through the corresponding needle bar mounting holes 6-1a along the direction of the piercing hook 6-2a. With the above design, on the one hand, it is convenient to assemble the needle bars 6-2, and on the other hand, the needle bars 6-2 can be used to improve the strength of both sides of the closed ring 6-1, so that the closed ring 6-1 can naturally bend and close at the weak area where the needle bar mounting holes 6-1a are located when closing, thereby improving the tightness of the closure clamp. The inner side of the closed loop 6-1 also has a hook pull hole 6-1b corresponding to the position of the aforementioned needle bar mounting hole 6-1a. The hook pull line 7b is connected to one end of the corresponding needle bar 6-2 through the corresponding hook pull hole 6-1b, and is used to pull the needle bar 6-2 to move in the opposite direction to the puncture hook 6-2a so that the puncture hook 6-2a pierces the corresponding hook extrusion hole 6-1c. In the initial state, the tip of the puncture hook 6-2a is located in the hook extrusion hole 6-1c. By pulling the needle bar 6-2, the tip of the puncture hook 6-2a extends out along the hook extrusion hole 6-1c, thereby allowing it to adhere to the tissue wall. Two hook-and-drawn lines 7b are also provided, each controlling one needle bar 6-2. This makes the pulling operation of the needle bar 6-2 simple and convenient, and can stably extend the puncture hook 6-2a and firmly insert it into the tissue, ensuring the strong adhesion between the closure ring 6-1 and the left atrial appendage tissue wall. The aforementioned closure ring 6-1, needle bar 6-2, and puncture hook 6-2a are all made of metal materials, such as stainless steel, nickel-titanium alloy, and cobalt-chromium alloy. In this embodiment, nickel-titanium alloy is preferred, as it is a shape-memory metal that can stably maintain the set shape after implantation, thereby further ensuring the closure stability and reliability of the left atrial appendage; of course, biocompatible cobalt-chromium alloy, etc., can also be used.

[0071] catch Figure 14 and Figure 15 As shown, in this embodiment, several support rod connecting holes 6-1d are distributed on the inner side of the closed ring 6-1. The closing clamp opening and closing pull wire 7a passes through the corresponding telescopic support rod 4 and connects to the corresponding support rod connecting hole 6-1d. When the closing clamp opening and closing pull wire 7a is tightened, the end of the telescopic support rod 4 can be inserted into the support rod connecting hole 6-1d, so that the free end of the telescopic support rod 4 is stably connected with the closed ring 6-1, realizing the stable opening of the closed ring 6-1. After the closed ring 6-1 in the closed state and the telescopic support rod 4 in the retracted state are pushed out from the sleeve 1b, the direction of the closed ring 6-1 is controlled by pulling the two closing clamp opening and closing pull wires 7a located in the middle of the closed ring 6-1. See the specific reference. Figure 3As shown, the end of the telescopic support rod 4 in the retracted state is located in the middle of the closed loop 6-1 in the closed state. At this time, the two closing clamp opening and closing pull wires 7a in the middle of the closed loop 6-1 are the shortest. By pulling these two closing clamp opening and closing pull wires 7a, the closed loop 6-1 can be flipped outward, thereby controlling the direction of the closed loop 6-1. It is convenient to adjust its relative position with the left atrial appendage by controlling the direction of the closed loop 6-1, so as to ensure the implantation accuracy of the closed loop 6-1.

[0072] like Figure 14 and Figure 15 As shown, the interlocking assembly includes an upper locking buckle 6-3 and a lower locking buckle 6-4 that can be interlocked. The upper locking buckle 6-3 and the lower locking buckle 6-4 adopt a mechanical interlocking structure. The upper locking buckle 6-3 has a locking hook facing the lower locking buckle 6-4. The upper locking buckle 6-3 and the lower locking buckle 6-4 are respectively located on the closed loop 6-1 and are located in the middle of the corresponding needle bar 6-2. The upper locking buckle 6-3 and the lower locking buckle 6-4 are each connected to a locking pull wire 7c. The locking buckle 6-3 and the lower locking buckle 6-4 are deformed by pulling the locking pull wire 7c to lock or disengage. When the locking cable 7c is pulled, the upper locking buckle 6-3 and the lower locking buckle 6-4 deform to different degrees on the closed ring 6-1, causing the locking hook on the upper locking buckle 6-3 to separate from the lower locking buckle 6-4. In the initial state, the upper locking buckle 6-3 and the lower locking buckle 6-4 can be in a disengaged state. When the closed ring 6-1 changes from an open state to a closed state, pulling the locking cable 7c deforms the upper locking buckle 6-3 and the lower locking buckle 6-4, causing the locking hook on the upper locking buckle 6-3 to pass over the lower locking buckle 6-4. After releasing the locking cable 7c, the upper locking buckle 6-3 and the lower locking buckle 6-4 reset and lock together. The interlocking assembly with the above-mentioned mechanical interlocking structure has a locking direction that is the closing deformation direction of the closed ring 6-1, making the closed ring 6-1 securely and reliably locked when closed, and not easy to loosen. Furthermore, the pulling direction of the locking cable 7c on the upper and lower locking buckles is perpendicular to the closed ring, which can easily achieve the locking or disengagement control of the upper and lower locking buckles.

[0073] like Figures 7 to 13As shown, in this embodiment, a left atrial appendage closure device has a telescopic support rod 4 with at least two interlocking support tubes. A locking assembly 4-7 is provided between adjacent support tubes. The locking assembly 4-7 includes several locking blocks 4-7-1 distributed circumferentially. Each locking block 4-7-1 is held together by a hoop 4-7-2 to form an integral rotating structure. Each locking block 4-7-1 can rotate around the hoop 4-7-2. The hoop 4-7-2 is located on the inner side of the support tube. At the tail end, specifically, an annular groove 4-9 can be provided on the inner wall of the tail end of the inner support tube. The hoop 4-7-2 can be engaged in the annular groove 4-9, thus restricting the locking assembly 4-7 on the inner support tube. The inner side of each locking block 4-7-1 has an inner conical surface 4-7-1a that forms a conical hole. The end of the locking block 4-7-1 extending outward from the tail end of the support tube has a locking flange 4-7-1b extending outward. The inner side of the front end of the outer support tube, away from the wall, is provided with a locking flange... A locking groove 4-8 is provided to mate with the locking flange 4-7-1b. The ends of each locking block 4-7-1 furthest from the locking flange 4-7-1b are connected together by an elastic ring 4-7-3, allowing each locking block 4-7-1 to have an elastic tendency to expand outwards due to rotation around the hoop 4-7-2. When each support tube is in a stretched state, the locking flange 4-7-1b engages in the corresponding locking groove 4-8. The telescopic support rod 4 also has... There is an unlocking trigger rod 4-4 capable of axial pressing movement. The tail end of the unlocking trigger rod 4-4 has a pressing part 4-4a, and the front end has a trigger part 4-4b that mates with the inner conical surface 4-7-1a of each locking block 4-7-1. By axially pressing the unlocking trigger rod 4-4, the trigger part 4-4b is driven to extend into the conical hole formed by each locking block 4-7-1, causing each locking block 4-7-1 to rotate around the hoop 4-7-2, thereby disengaging the locking flange 4-7-1b from the locking groove 4-8 and unlocking it. Furthermore, as... Figure 11 As shown, after each locking block 4-7-1 is unlocked, the unlocking trigger rod 4-4 can pass through the conical hole formed by each locking block 4-7-1, thereby allowing adjacent support tubes to retract freely. To improve the telescopic ratio, this embodiment preferably adopts a three-section telescopic support rod 4, specifically including a first support tube 4-1, a second support tube 4-2, and a third support tube 4-3. The second support tube 4-2 is sleeved inside the first support tube 4-1, and the third support tube 4-3 is sleeved inside the second support tube 4-2. The tail ends of both the second support tube 4-2 and the third support tube 4-3 have a set of locking components 4-7. Figure 8As shown, when the telescopic support rod 4 is in the stretched state, the trigger part 4-4b of the unlocking trigger rod 4-4 extends to the locking assembly 4-7 at the tail of the second support tube 4-2. When the pressing part 4-4a is pressed, causing the unlocking trigger rod 4-4 to move upward, its trigger part 4-4b extends into the conical hole formed by the locking blocks 4-7-1, thereby unlocking the first support tube 4-1 and the second support tube 4-2, causing the second support tube 4-2 and the third support tube 4-3 to retract together. When the second support tube 4-2 retracts to its shortest length, the locking assembly 4-7 at the tail of the third support tube 4-3 moves to a position close to the trigger part 4-4b of the unlocking trigger rod 4-4. Pressing the unlocking trigger rod 4-4 again will unlock the second support tube 4-2 and the third support tube 4-3, and the retraction of the third support tube 4-3 will continue. The extension, locking, unlocking, and retraction of the telescopic support rod 4 are key to enabling the closed loop 6-1 to transition from its initial closed state to its open state and then to its straight closed state. Locking the telescopic support rod 4 in its extended state via the latch assembly 4-7 ensures the stability of the telescopic support rod 4 in its extended state, facilitating the support of the closed loop 6-1 to maintain its circular open state. Simultaneously, the latch assembly 4-7 can be unlocked by pressing, allowing the telescopic support rod 4 to retract, facilitating the closure of the closed loop 6-1 into a straight shape, resulting in good operational stability. Furthermore, the latch assembly 4-7 has a simple and compact design, allowing it to be installed within a small-diameter telescopic support rod 4. Its ingenious design allows for multi-level unlocking of the latch assembly via the pressing action of the unlocking trigger rod 4-4, making operation convenient.

[0074] like Figure 8 and Figure 11 As shown, in this embodiment, the unlocking trigger rod 4-4 is located inside the support tube closest to the support plate 3 in the telescopic support rod 4, i.e., the first support tube 4-1. The tail end of this support tube is provided with a tail sleeve 4-5 and a return spring 4-6. The unlocking trigger rod 4-4 passes through the tail sleeve 4-5, and the return spring 4-6 is sleeved on the unlocking trigger rod 4-4. One end of the return spring 4-6 acts on the tail sleeve 4-5, and the other end acts on the pressing part 4-4a, which is used to drive the unlocking trigger rod 4-4 to reset after being pressed. The unlocking trigger rod 4-4 has good pressing feedback performance, further improving the convenience of surgical operation.

[0075] To facilitate the unlocking operation of the telescopic support rod 4, combined with Figure 4 , Figure 5 and Figure 18As shown, the support plate 3 is also provided with 90° guide holes 3-4 corresponding to the positions of each telescopic support rod 4. The radial opening of each 90° guide hole 3-4 on the support plate 3 is opposite to the tail end of the telescopic support rod 4 in the unfolded state. The support tube 2 has an unlocking operation rod 9. The front end of the unlocking operation rod 9 has a flexible pressing section 9-1. The flexible pressing section 9-1 passes through the corresponding 90° guide hole 3-4. The pressing movement of the unlocking operation rod 9 drives each flexible pressing section 9-1 to extend out from the radial hole 3-1c of the 90° guide hole 3-4 and drive the corresponding unlocking trigger rod 4-4 to perform the pressing unlocking action. The flexible pressing section 9-1 can move within the 90° guide hole 3-4, so that its end extends out from the radial hole 3-1c of the 90° guide hole 3-4. When the telescopic support rod 4 switches from the retracted state to the extended state, the radial hole 3-1c is opposite to the pressing part 4-4a at the tail of the telescopic support rod 4. By pressing the unlocking operation rod 9, the pressing part 4-4a is triggered by the flexible pressing section 9-1, thereby realizing the unlocking and retraction of the telescopic support rod 4. This makes it convenient to unlock the telescopic support rod 4 from the outside. It has the advantages of simple structure and convenient operation.

[0076] Reference Figure 6 As shown, the connecting seat 3-1 has short shafts 3-1a on both sides, and the rotating seat 4a has a rotating shaft hole 4a-1 that rotates with the short shafts 3-1a. The connecting seat 3-1 also has an axial hole 3-1b that runs vertically through the rod. When the telescopic support rod 4 is in the retracted state, the closing clamp opening and closing cable 7a passes through the axial hole 3-1b and enters the corresponding telescopic support rod 4. The axial hole 3-1b intersects with the 90° guide hole 3-4, and there is a wire groove 3-1d on the upper side of the connecting seat 3-1 that connects the axial hole 3-1b and the corresponding radial hole 3-1c. When the telescopic support rod 4 switches from the retracted state to the extended state, the closing clamp opening and closing cable 7a passing through the axial hole 3-1b passes through the wire groove 3-1d and enters the radial hole 3-1c. To prevent the closing clamp opening / closing cable 7a from interfering with the extension of the flexible pressing section 9-1, a clearance groove can be provided at the end of the flexible pressing section 9-1. When the flexible pressing section 9-1 extends along the radial hole 3-1c, the closing clamp opening / closing cable 7a can enter the clearance groove, thereby avoiding obstruction of the flexible pressing section 9-1. In addition, the outer periphery of the support plate 3 also has a cable hole 3-2 opposite to the aforementioned axial hole 3-1b, through which the closing clamp opening / closing cable 7a passes.

[0077] In this embodiment, the aforementioned closing clamp opening and closing pull line 7a, hook pull line 7b, and locking pull line 7c, as well as the core rod push-pull rod 8 and unlocking operation rod 9, all extend out of the tail end of the support tube 2. Correspondingly, a pull line handle can be provided at the tail end of each closing clamp opening and closing pull line 7a, hook pull line 7b, and locking pull line 7c, and a corresponding push-pull handle can be provided at the tail end of the core rod push-pull rod 8 and unlocking operation rod 9. Each pull line handle and push-pull handle can be set to different colors and / or shapes to facilitate the differentiation of the corresponding pull line and operation rod during operation.

[0078] Figure 17 and Figure 19 The diagram shows the structure of the closure clip assembly in the open state. To facilitate a further understanding of the structural principle of the left atrial appendage closure device of the present invention, the following description, in conjunction with the accompanying drawings, further illustrates the usage process of the invention:

[0079] Figure 1 This is the initial state of the left atrial appendage closure device. At this time, the telescopic support rod 4 is in the retracted state, the closure clamp assembly 6 is in the initial closed state (the interlocking assembly is not engaged), and both the telescopic support rod 4 and the closure clamp assembly 6 are housed in the cannula 1b, while the support tube 2 is located in the hypotube 1a. During operation, the delivery catheter 1 follows the puncture device and enters the designated position, that is, through the blood vessel into the left atrial appendage orifice.

[0080] Then, by pushing forward using the support tube 2, the telescopic support rod 4 and the closing clamp assembly 6 are pushed out of the sleeve 1b. At this time, the two shortest closing clamp opening and closing pull lines 7a in the middle of the closing ring 6-1 tightly connect the two telescopic support rods 4 to the closing ring 6-1, pushing the core rod push-pull rod 8 to move the core rod 5 forward. Under the pushing action at the end of the core rod 5, the closing clamp assembly 6 can change its overall direction, so that the closing clamp assembly 6 and the core rod 5 are basically perpendicular. When the core rod 5 is not set, the direction of the closing clamp assembly 6 can be adjusted by pulling the two shortest closing clamp opening and closing pull lines 7a.

[0081] Pulling the opening and closing cables 7a of the closing clamps (except for the shortest one) connects the ends of each telescopic support rod 4 to the closing ring 6-1. Under the tension of the opening and closing cables 7a, each telescopic support rod 4 unfolds outward, thus expanding the closing ring 6-1. Figure 17 The shape shown is circular or nearly circular.

[0082] Adjust the opened closed loop 6-1 to the position of the opening of the left atrial appendage, so that it fits against the tissue wall of the neck of the left atrial appendage; then pull the two hook lines 7b so that the tip of the puncture hook 6-2a extends out along the hook extrusion hole 6-1c and pierces into the tissue wall to form a barb. Under the action of the barb of the puncture hook 6-2a, the closed loop 6-1 is connected to the tissue wall.

[0083] Next, push the unlocking lever 9 to unlock and retract each telescopic support rod 4, and pull and adjust the corresponding closing clamp opening and closing cable 7a and locking cable 7c, causing the telescopic support rod 4 to begin retracting. The closing ring 6-1 then begins to close along with the left atrial appendage. When the closing ring 6-1 is closed... Figure 15 When in the "I" shaped position, adjust the locking cable 7c to make the upper and lower locking buckles interlock. When setting the core rod 5, after the telescopic support rod 4 is retracted and closed, the telescopic support rod 4 can be removed through the support tube 2. Then, using the core rod push-pull rod 8 and the core rod 5 to maintain the closed loop 6-1, pull the locking cable 7c to complete the final closure and interlocking of the closed loop 6-1.

[0084] Finally, release all the pull lines and retract the other components along the delivery guide tube 1. Cut the closing clamp opening and closing pull line 7a, the hook pull line 7b, and the locking pull line 7c, leaving only the closing clamp assembly 6. The two hook pull lines 7b can be knotted and then cut. Use the knotted hook pull lines 7b to maintain a certain tension on the needle bar 6-2 to prevent the puncture hook 6-2a from retracting.

[0085] After the left atrial appendage is closed using the closure clamp assembly 6, the blood supply to the left atrial appendage remains intact, and it will not cause atrophy of the left atrial appendage. On the one hand, the fixation of the puncture hook 6-2a will not be reduced due to atrophy of the left atrial appendage, and on the other hand, it can ensure that other functions of the left atrial appendage are not affected.

[0086] This invention discloses a left atrial appendage closure device that utilizes a closure clip to close the left atrial appendage, replacing previous left atrial appendage occlusion techniques. This ensures the reliability and long-term effectiveness of left atrial appendage closure. Specifically, the closure clip is inserted into the opening of the left atrial appendage using a delivery catheter while in a closed state. It is then opened at the left atrial appendage opening by the cooperation of a telescopic support rod and a control cable. A puncture hook inside the closure clip pierces the tissue wall of the left atrial appendage opening to achieve contact. Finally, the closure clip's "I"-shaped closure achieves closure of the left atrial appendage opening. Compared to existing left atrial appendage occlusion devices, the puncture hook on the outer periphery of the closure clip can radially pierce the tissue, and the closure of the clip drives the closure of the left atrial appendage opening. This makes the connection between the closure clip and the left atrial appendage more secure and less prone to detachment. It also eliminates the problem of decreased reliability of the left atrial appendage seal due to loosening or movement, ensuring the long-term effectiveness of left atrial appendage closure and reducing complications caused by detachment and unreliable sealing.

[0087] The present invention and its embodiments have been described above illustratively. This description is not restrictive, and the figures shown are only one embodiment of the present invention; the actual structure is not limited thereto. Therefore, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the present invention, such designs should fall within the protection scope of the present invention.

Claims

1. A left atrial appendage closure device, characterized in that: include Delivery conduit (1), with a sleeve (1b) at its front end; Support tube (2), which is inserted into delivery conduit (1) and is used to be delivered to a designated position under the guidance of delivery conduit (1); The support plate (3) is installed at the front end of the support tube (2) and has several connecting seats (3-1) distributed circumferentially. Telescopic support rods (4) are mounted at one end on the corresponding connecting seat (3-1) of the support plate (3) via a rotating seat (4a). Each telescopic support rod (4) has a retracted state that converges towards the center and an extended state that radiates radially relative to the support plate (3). The retracted state and the extended state can be switched by rotating the telescopic support rod (4). Each telescopic support rod (4) also has a locking assembly (4-7) for keeping the telescopic support rod (4) in a stretched state and for triggering unlocking to retract the telescopic support rod (4). The closing clamp assembly (6) includes a tubular closing ring (6-1), in which a pullable needle bar (6-2) is installed, the needle bar (6-2) having a plurality of piercing hooks (6-2a), the outer side of the closing ring (6-1) having a plurality of hook extrusion holes (6-1c) corresponding to the positions of the piercing hooks (6-2a), and the closing ring (6-1) also having an interlocking assembly for keeping the closing ring (6-1) in a "I" closed state; The closed loop (6-1) in the closed state and the telescopic support rod (4) in the retracted state are housed in the sleeve (1b) mentioned above, and can be pushed forward out of the sleeve (1b) under the action of the support tube (2); The control cable (7) includes a closure clamp opening and closing cable (7a), a hook cable (7b), and a locking cable (7c) located inside the support tube (2). The front end of the closure clamp opening and closing cable (7a) passes through the corresponding telescopic support rod (4) and connects to the closing ring (6-1). It is used to tighten the corresponding closure clamp opening and closing cable (7a) to make the free end of the corresponding telescopic support rod (4) connect with the closing ring (6-1), and to open the closing ring (6-1) when the telescopic support rod (4) is converted to the unfolded state. The closure clamp opening and closing cable (7a) can also be used in the above-mentioned locking assembly. (4-7) After unlocking, the retraction of the telescopic support rod (4) is used to control the closure ring (6-1) to close in an "I"-shaped closed state; the front end of the hook pull line (7b) passes through the support plate (3) and is connected to the needle bar (6-2) inside the closure ring (6-1), which is used to pull the needle bar (6-2) when the closure ring (6-1) is in an open state so that the piercing hook (6-2a) pierces the corresponding hook extrusion hole (6-1c); the front end of the locking pull line (7c) is connected to the interlocking component on the closure ring (6-1), which is used to control the interlocking component to engage or disengage through the locking pull line (7c).

2. The left atrial appendage closure device according to claim 1, characterized in that: The delivery conduit (1) also includes a thiopancreatic tube (1a), and the sleeve (1b) is installed at the front end of the thiopancreatic tube (1a).

3. The left atrial appendage closure device according to claim 1, characterized in that: The support plate (3) is also provided with a core rod mounting hole (3-3) at its center. A core rod (5) capable of axial movement is provided in the core rod mounting hole (3-3). A core rod push-pull rod (8) is connected to the tail of the core rod (5). The core rod (5) also has a first wire outlet hole (5a) and a second wire outlet hole (5b) that penetrate its front end face. The hook pull line (7b) is inserted in the first wire outlet hole (5a), and the lock pull line (7c) is inserted in the second wire outlet hole (5b).

4. The left atrial appendage closure device according to claim 1, characterized in that: Two needle bars (6-2) are centrally symmetrically arranged within the closed loop (6-1). The outer side of the closed loop (6-1) has two oppositely arranged needle bar mounting holes (6-1a). The needle bars (6-2) are installed within the closed loop (6-1) through the corresponding needle bar mounting holes (6-1a) in the direction of the piercing hook (6-2a). The inner side of the closed loop (6-1) also has a hook pull line hole (6-1b) opposite to the position of the aforementioned needle bar mounting holes (6-1a). The hook pull line (7b) is connected to one end of the corresponding needle bar (6-2) through the corresponding hook pull line hole (6-1b) and is used to pull the needle bar (6-2) to move in the opposite direction of the piercing hook (6-2a) so that the piercing hook (6-2a) pierces out of the corresponding hook extrusion hole (6-1c).

5. The left atrial appendage closure device according to claim 4, characterized in that: The inner side of the closed loop (6-1) is also provided with several support rod connection holes (6-1d). The closing clamp opening and closing pull wire (7a) passes through the corresponding telescopic support rod (4) and is connected to the corresponding support rod connection hole (6-1d). After the closed loop (6-1) in the closed state and the telescopic support rod (4) in the retracted state are pushed out from the sleeve (1b), the direction of the closed loop (6-1) is controlled by pulling the two closing clamp opening and closing pull wires (7a) located in the middle of the closed loop (6-1) in the closed state.

6. The left atrial appendage closure device according to claim 4, characterized in that: The interlocking assembly includes an upper locking buckle (6-3) and a lower locking buckle (6-4) that can interlock with each other. The upper locking buckle (6-3) and the lower locking buckle (6-4) are respectively located on the closed loop (6-1) and are located in the middle of the corresponding needle bar (6-2). The upper locking buckle (6-3) and the lower locking buckle (6-4) are each connected to a locking pull wire (7c). The upper locking buckle (6-3) and the lower locking buckle (6-4) are deformed by pulling the locking pull wire (7c) to lock or unlock.

7. The left atrial appendage closure device according to any one of claims 1 to 6, characterized in that: The telescopic support rod (4) has at least two interlocking support tubes. A locking assembly (4-7) is provided between two adjacent support tubes. The locking assembly (4-7) includes a plurality of locking blocks (4-7-1) distributed circumferentially. Each locking block (4-7-1) is held together by a hoop (4-7-2). The hoop (4-7-2) is located at the tail end of the support tube on the inner side. The inner side of each locking block (4-7-1) has a surrounding structure. The inner conical surface (4-7-1a) of the conical hole; the end of the locking block (4-7-1) extending outward from the tail end of the support tube has a locking flange (4-7-1b); the inner side of the front end of the outer support tube, away from the wall, is provided with a locking groove (4-8) that can cooperate with the locking flange (4-7-1b); the end of each locking block (4-7-1) away from the locking flange (4-7-1b) is connected inwardly by an elastic ring (4-7-3). This allows each locking block (4-7-1) to rotate around the hoop (4-7-2), causing the locking flange (4-7-1b) to expand outwards with an elastic tendency; when each of the support tubes is in a stretched state, the locking flange (4-7-1b) engages in the corresponding locking groove (4-8); the telescopic support rod (4) also has an unlocking trigger rod (4-4) capable of axial pressing movement, the tail end of the unlocking trigger rod (4-4) having a pressing... Part (4-4a) has a trigger part (4-4b) at the front end that engages with the inner conical surface (4-7-1a) of each of the locking blocks (4-7-1). By axially pressing the unlocking trigger rod (4-4), the trigger part (4-4b) is driven to extend into the conical hole formed by each of the locking blocks (4-7-1), causing each of the locking blocks (4-7-1) to rotate around the hoop (4-7-2), thereby causing the locking flange (4-7-1b) to disengage from the locking groove (4-8) and unlock.

8. The left atrial appendage closure device according to claim 7, characterized in that: The unlocking trigger rod (4-4) is located in the support tube closest to the support plate (3) in the telescopic support rod (4). The tail end of the support tube is provided with a tail sleeve (4-5) and a return spring (4-6). The unlocking trigger rod (4-4) passes through the tail sleeve (4-5). The return spring (4-6) is sleeved on the unlocking trigger rod (4-4). One end of the return spring (4-6) acts on the tail sleeve (4-5), and the other end acts on the pressing part (4-4a) to drive the unlocking trigger rod (4-4) to reset after being pressed.

9. The left atrial appendage closure device according to claim 8, characterized in that: The support plate (3) is also provided with 90° guide holes (3-4) corresponding to the positions of each telescopic support rod (4). The radial opening of each 90° guide hole (3-4) on the support plate (3) is opposite to the tail end of the telescopic support rod (4) in the unfolded state. The support tube (2) has an unlocking operation rod (9). The front end of the unlocking operation rod (9) has a flexible pressing section (9-1). The flexible pressing section (9-1) passes through the corresponding 90° guide hole (3-4). The pressing movement of the unlocking operation rod (9) drives each flexible pressing section (9-1) to extend out from the radial hole (3-1c) of the 90° guide hole (3-4) and drive the corresponding unlocking trigger rod (4-4) to perform the pressing unlocking action.

10. The left atrial appendage closure device according to claim 9, characterized in that: The connecting seat (3-1) has short shafts (3-1a) on both sides. The rotating seat (4a) has a rotating shaft hole (4a-1) that rotates with the short shafts (3-1a). The connecting seat (3-1) also has an axial hole (3-1b) that runs vertically through the connecting seat. The axial hole (3-1b) intersects with the 90° guide hole (3-4). The connecting seat (3-1) has a wire groove (3-1d) on its upper side that connects the axial hole (3-1b) and the corresponding radial hole (3-1c). When the telescopic support rod (4) switches from the retracted state to the extended state, the closing clamp pull wire (7a) that passes through the axial hole (3-1b) enters the radial hole (3-1c) through the wire groove (3-1d).

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