Sample analyzer and dispensing unit

Abstract

The invention is applicable to the field of in vitro diagnostic equipment, and discloses a sample analyzer and a dispensing component. The sample analyzer comprises a sample distribution device, a reagent distribution device, an information acquisition part, a sample detection device and a controller. The sample distribution device comprises a first sample dispensing assembly and a second sample dispensing assembly, and the first sample dispensing assembly and the second sample dispensing assembly are two dispensing assemblies of which at least part of components can independently execute sample distribution action. At least part of components of at least one of the first sample dispensing assembly and the second sample dispensing assembly are associated with sample adding correction parameters; the controller is configured to correct a sample distribution amount of the first sample dispensing assembly and / or the second sample dispensing assembly in executing the sample distribution action according to sample adding correction parameters of the first sample dispensing assembly and / or the second sample dispensing assembly. According to the invention, the detection efficiency is improved, and the calibration cost is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of in-vitro diagnostic equipment, in particular to a sample analyzer and a dispensing component applied to the sample analyzer. BACKGROUND

[0002] A sample analyzer provided by the prior art adopts a single-needle pipetting device to dispense liquid, i.e. all the suction and dispensing actions of the same kind of liquid are performed by a single pipetting needle of a single pipetting device, i.e. the dispensing of the same kind of liquid in all detection items in the sample analyzer is performed by the same pipetting needle, for example, the sample dispensing actions of all detection items in the sample analyzer are performed by the same sample needle, and the reagent dispensing actions of all detection items are performed by the same reagent needle. Since the pipetting speed of the single-needle pipetting device has an upper limit, the sample detection speed of the whole machine is also limited, which is not conducive to the improvement of the detection speed of the sample analyzer. In order to improve the detection speed of the sample analyzer, the related art proposes a scheme of using a double-needle pipetting device or a triple-needle pipetting device or even more needle pipetting devices to dispense samples or reagents, i.e. using two sample needles or three sample needles or more sample needles to perform sample dispensing actions respectively, or using two reagent needles or three reagent needles or more reagent needles to perform reagent dispensing actions respectively. When using a double-needle pipetting device or a triple-needle pipetting device or even more needle pipetting devices to dispense samples or reagents, there will be differences in dispensing accuracy when different pipetting needle channels dispense the same kind of liquid, which may result in that the precision of the whole machine does not meet the performance requirements of clinical analysis.

[0003] To solve the problem of precision decline caused by pipetting with different pipetting needles, the solutions proposed by the related art mainly include the following two schemes: (1) Scheme one, each pipetting needle is used to perform pipetting action in different detection items, that is, different pipetting needles are responsible for pipetting action of different specified detection items respectively, and do not interfere with each other. In this scheme, each pipetting needle performs clinical calibration of the corresponding specified item independently; scheme two, each detection item is calibrated for each pipetting needle. Thus, several pipetting needles require several sets of calibration standards and corresponding reagents. However, both of the two schemes have disadvantages in specific application, which are embodied in: (1) In scheme one, since each pipetting needle is used to perform pipetting action in different specified detection items, when there are many samples to perform a certain detection item in a time period, a phenomenon of long queue of many samples waiting for pipetting action under the pipetting needle corresponding to the detection item will occur, while other pipetting needles are in idle state, which causes great waste of resources and leads to speed reduction in a large number of clinical detection scenarios, thereby greatly reducing the actual detection efficiency of the sample analyzer, which is contrary to the speed-up goal of using multiple needles for pipetting. (2) In scheme two, since each detection item needs to be calibrated for each pipetting needle respectively, on the one hand, the use amount of calibration standards and corresponding reagents is increased, thereby increasing the calibration cost; on the other hand, the calibration efficiency is reduced; and on the other hand, since the performance transmission chain of the clinical results and the pipetting accuracy is long, or the accuracy difference of different pipetting needles cannot be reflected by single detection clinical data, therefore, the clinical item calibration may cause more uncontrollable calibration deviation. SUMMARY

[0004] The first object of the present application is to provide a sample analyzer which aims to solve the technical problem that the detection efficiency and calibration cost cannot be considered when a multi-needle pipetting device is used to perform pipetting action of the same liquid in the related art.

[0005] To achieve the above object, the present application provides a solution: a sample analyzer, comprising:

[0006] A sample dispensing device, the sample dispensing device comprising a first sample dispensing assembly and a second sample dispensing assembly, the first sample dispensing assembly and the second sample dispensing assembly are respectively used to perform the following sample dispensing action: sucking sample from a sample container and dispensing at least part of the sucked sample into a reaction container; wherein the first sample dispensing assembly and the second sample dispensing assembly are two dispensing assemblies whose at least part of the components can perform the sample dispensing action independently of each other, and at least part of the components of at least one of the first sample dispensing assembly and the second sample dispensing assembly are associated with a sample addition correction parameter;

[0007] A reagent dispensing device for performing a reagent dispensing action of sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into a reaction container;

[0008] An information acquisition component for acquiring a sample addition correction parameter of the first sample dispensing assembly and / or a sample addition correction parameter of the second sample dispensing assembly;

[0009] A detection device for detecting a sample to be tested made of at least a sample dispensed by the sample dispensing device and a reagent dispensed by the reagent dispensing device;

[0010] A controller configured to acquire a sample addition correction parameter of the first sample dispensing assembly and / or a sample addition correction parameter of the second sample dispensing assembly according to information fed back by the information acquisition component, and correct a sample dispensing amount of the first sample dispensing assembly in performing the sample dispensing action and / or a sample dispensing amount of the second sample dispensing assembly in performing the sample dispensing action according to the sample addition correction parameter of the first sample dispensing assembly and / or the sample addition correction parameter of the second sample dispensing assembly.

[0011] As an embodiment, at least part of components of at least one of the first sample dispensing assembly and the second sample dispensing assembly is configured with an identification code, and the identification code is associated with a sample addition correction parameter of the component;

[0012] The information acquisition component acquires the sample addition correction parameter of the first sample dispensing assembly and / or the sample addition correction parameter of the second sample dispensing assembly by recognizing the identification code.

[0013] As an embodiment, a label paper is pasted on at least part of components of at least one of the first sample dispensing assembly and the second sample dispensing assembly, and the identification code is provided on the label paper.

[0014] As an embodiment, the first sample dispensing assembly includes a first suction component, and the second sample dispensing assembly includes a second suction component, the first suction component and the second suction component are two suction components capable of independently performing the sample dispensing action, and at least one of the first suction component and the second suction component is associated with a sample addition correction parameter.

[0015] As an implementation form, the first suction component is configured with a first identification code, the first identification code is associated with sample loading correction parameters of the first suction component, the information acquisition component is configured to identify the first identification code, and the controller is further configured to: acquire the sample loading correction parameters of the first suction component according to the information fed back by the information acquisition component identifying the first identification code; and correct the sample dispensing amount of the first sample dispensing assembly in performing the sample dispensing action according to at least the sample loading correction parameters of the first suction component, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly and the sample dispensing accuracy of the second sample dispensing assembly is less than or equal to a first preset value; and / or,

[0016] The second suction component is configured with a second identification code, the second identification code is associated with sample loading correction parameters of the second suction component, the information acquisition component is configured to identify the second identification code, and the controller is further configured to: acquire the sample loading correction parameters of the second suction component according to the information fed back by the information acquisition component identifying the second identification code; and correct the sample dispensing amount of the second sample dispensing assembly in performing the sample dispensing action according to at least the sample loading correction parameters of the second suction component, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly and the sample dispensing accuracy of the second sample dispensing assembly is less than or equal to a first preset value.

[0017] As an implementation form, the first suction component is associated with sample loading correction parameters of the first suction component, the second suction component is associated with sample loading correction parameters of the second suction component, and the sample loading correction parameters of the first suction component and the sample loading correction parameters of the second suction component take the same target value as a sample loading correction reference.

[0018] As an implementation form, the first suction component is configured with a first identification code, the first identification code is associated with sample loading correction parameters of the first suction component, and the controller is further configured to: acquire the sample loading correction parameters of the first suction component according to the information fed back by the information acquisition component identifying the first identification code before controlling the first suction component to perform the sample dispensing action on the sample analyzer for the first time; and / or,

[0019] The second suction component is configured with a second identification code, the second identification code is associated with sample loading correction parameters of the second suction component, and the controller is further configured to: acquire the sample loading correction parameters of the second suction component according to the information fed back by the information acquisition component identifying the second identification code before controlling the second suction component to perform the sample dispensing action on the sample analyzer for the first time.

[0020] As an implementation, the first pipetting component is configured with a first identification code, the first identification code is associated with sample addition correction parameters of the first pipetting component, and the controller is further configured to: when the first pipetting component is replaced or first assembled on the sample analyzer, acquire sample addition correction parameters of the first pipetting component according to information fed back by the information acquisition component identifying the first identification code; and / or,

[0021] The second pipetting component is configured with a second identification code, the second identification code is associated with sample addition correction parameters of the second pipetting component, and the controller is further configured to: when the second pipetting component is replaced or first assembled on the sample analyzer, acquire sample addition correction parameters of the second pipetting component according to information fed back by the information acquisition component identifying the second identification code.

[0022] As an implementation, the first pipetting component is a first sample needle, and the second pipetting component is a second sample needle; or,

[0023] The first pipetting component is a first pipetting power component, and the first pipetting power component is used to provide driving force for the first sample needle to perform pipetting action; the second pipetting component is a second pipetting power component, and the second pipetting power component is used to provide driving force for the second sample needle to perform pipetting action.

[0024] As an implementation, the controller is configured to perform the following item calibration process of the first detection item: control the first sample dispensing assembly to suck item calibration samples from a calibration sample container and dispense them into a reaction container, control the reagent dispensing device to suck reagents from a reagent container and dispense them into the reaction container; control the detection device to detect calibration solution at least made of the item calibration samples and reagents in the reaction container, and obtain first calibration data corresponding to the first detection item according to detection information fed back by the detection device;

[0025] The controller is further configured to perform the following second detection process of the first detection item: control the second sample dispensing assembly to perform the sample dispensing action, control the reagent dispensing device to perform the reagent dispensing action, control the sample detection device to detect the to-be-tested solution at least made of the sample dispensed by the second sample dispensing assembly and the reagent dispensed by the reagent dispensing device, obtain second detection data according to detection information fed back by the detection device, and obtain a second detection result according to the second detection data and the first calibration data corresponding to the first detection item.

[0026] As an implementation form, a deviation of a sample dispensing precision of the first sample dispensing assembly and a sample dispensing precision of the second sample dispensing assembly is less than or equal to a first preset value, the first preset value is greater than or equal to zero and less than or equal to 5%; and / or,

[0027] The controller is further configured to control the first sample dispensing assembly and the second sample dispensing assembly to respectively perform the sample dispensing action of the same detection item of the two samples.

[0028] As an implementation form, the sample analyzer further comprises a reaction device, the reaction device is used to carry a reaction container to perform an incubation action of incubating a liquid containing at least a sample and a reagent;

[0029] The controller is further configured to control the first sample dispensing assembly and the second sample dispensing assembly to respectively perform the sample dispensing action of the same detection item of the two samples, control the same reagent dispensing device to respectively perform the reagent dispensing action of the same detection item of the two samples, control the same reaction device to respectively perform the incubation action of the same detection item of the two samples, and control the same detection device to respectively detect the to-be-tested liquid made of the two samples and reagents.

[0030] As an implementation form, the reagent dispensing device performing the reagent dispensing action comprises: sucking a magnetic bead reagent from a first reagent container and dispensing it into a reaction container, and sucking a label reagent from a second reagent container and dispensing it into the reaction container;

[0031] The reaction device is used to carry a reaction container to perform an incubation action of incubating at least the sample, the magnetic bead reagent, and the label reagent to make a first reaction liquid;

[0032] The sample analyzer further comprises a magnetic separation device and a substrate dispensing device, the magnetic separation device is used to perform a magnetic separation and cleaning operation on the first reaction liquid to make a second reaction liquid;

[0033] The substrate dispensing device is used to perform a substrate dispensing action of sucking a luminescent substrate reagent from a substrate reagent container and dispensing at least part of the sucked luminescent substrate reagent into a reaction container loaded with the second reaction liquid, so as to make the second reaction liquid and the luminescent substrate reagent into the to-be-tested liquid;

[0034] The detection device is used to detect the luminescent intensity of the to-be-tested liquid;

[0035] The controller is further configured to control the same magnetic separation device to perform the magnetic separation cleaning operation of the same detection item of two samples respectively; and control the same substrate dispensing device to perform the substrate dispensing action of the same detection item of the two samples respectively.

[0036] As an implementation form, the reagent dispensing device comprises at least two reagent dispensing assemblies which are capable of performing the reagent dispensing action independently at least in part and are associated with correction parameters; and / or,

[0037] The sample analyzer further comprises a reaction device for carrying a reaction container to perform an incubation action of incubating a liquid containing at least a sample and a reagent; the reaction device comprises at least two incubation assemblies which are capable of performing the incubation action independently at least in part and are associated with correction parameters; and / or,

[0038] The detection device comprises at least two detection assemblies which are capable of detecting the to-be-detected liquid independently at least in part and are associated with correction parameters.

[0039] A second object of the present application is to provide a sample analyzer, which comprises:

[0040] A sample dispensing device for performing a sample dispensing action of sucking a sample from a sample container and dispensing at least part of the sucked sample into a reaction container;

[0041] A reagent dispensing device comprising a first reagent dispensing assembly and a second reagent dispensing assembly, the first reagent dispensing assembly and the second reagent dispensing assembly are respectively used to perform a reagent dispensing action of sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into a reaction container; wherein the first reagent dispensing assembly and the second reagent dispensing assembly are two dispensing assemblies which are capable of performing the reagent dispensing action independently at least in part, and at least part of components of at least one of the first reagent dispensing assembly and the second reagent dispensing assembly is associated with a reagent addition correction parameter;

[0042] An information acquisition component for acquiring the reagent addition correction parameter of the first reagent dispensing assembly and / or the reagent addition correction parameter of the second reagent dispensing assembly;

[0043] A detection device for detecting a to-be-detected liquid made of at least a sample dispensed by the sample dispensing device and a reagent dispensed by the reagent dispensing device;

[0044] a controller configured to: acquire the reagent addition correction parameter of the first reagent dispensing assembly and / or the reagent addition correction parameter of the second reagent dispensing assembly according to the information fed back by the information acquisition component; and correct the liquid dispensing amount of the first reagent dispensing assembly in performing the liquid dispensing action and / or the liquid dispensing amount of the second reagent dispensing assembly in performing the liquid dispensing action according to the reagent addition correction parameter of the first reagent dispensing assembly and / or the reagent addition correction parameter of the second reagent dispensing assembly.

[0045] As an implementation form, at least part of components of at least one of the first reagent dispensing assembly and the second reagent dispensing assembly is configured with an identification code, and the identification code is associated with the reagent addition correction parameter of the component;

[0046] The information acquisition component acquires the reagent addition correction parameter of the first reagent dispensing assembly and / or the reagent addition correction parameter of the second reagent dispensing assembly by identifying the identification code.

[0047] A third object of the present application is to provide a sample analyzer, which comprises:

[0048] a pipetting device configured to perform a liquid dispensing action of: sucking a sample from a sample container and dispensing at least part of the sucked sample into a reaction container; and sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into the reaction container; wherein the pipetting device comprises a first pipetting assembly and a second pipetting assembly, the first pipetting assembly and the second pipetting assembly are two pipetting assemblies of which at least part of components can independently perform the liquid dispensing action, and at least part of components of the first pipetting assembly and / or the second pipetting assembly are associated with pipetting correction parameters;

[0049] an information acquisition component configured to acquire the pipetting correction parameter of the first pipetting assembly and / or the pipetting correction parameter of the second pipetting assembly;

[0050] a detection device configured to detect the to-be-detected liquid;

[0051] a controller configured to: acquire the pipetting correction parameter of the first pipetting assembly and / or the pipetting correction parameter of the second pipetting assembly according to the information fed back by the information acquisition component; and correct the liquid dispensing amount of the first pipetting assembly in performing the liquid dispensing action and / or the liquid dispensing amount of the second pipetting assembly in performing the liquid dispensing action according to the pipetting correction parameter of the first pipetting assembly and / or the pipetting correction parameter of the second pipetting assembly.

[0052] As one embodiment, at least part of components of at least one of the first pipetting assembly and the second pipetting assembly is provided with an identification code, and the identification code is associated with a pipetting correction parameter of the component;

[0053] The information acquisition component acquires the pipetting correction parameter of the first pipetting assembly and / or the pipetting correction parameter of the second pipetting assembly by recognizing the identification code.

[0054] A fourth object of the present application is to provide a dispensing component for dispensing a sample or for dispensing a reagent or for dispensing a sample and a reagent, the dispensing component being provided with an identification code, and the identification code being associated with a pipetting correction parameter of the dispensing component, and the pipetting correction parameter being used to correct a liquid dispensing amount of the dispensing component.

[0055] As one embodiment, the dispensing component is a sample needle for dispensing a sample, or a reagent needle for dispensing a reagent, or a pipetting needle for dispensing a sample and a reagent, or a sample aspirating and dispensing power component for driving the sample needle to perform an aspirating and dispensing action, or a reagent aspirating and dispensing power component for driving the reagent needle to perform an aspirating and dispensing action, or a pipetting power source for driving the pipetting needle to perform a liquid dispensing action; and / or,

[0056] The identification code is formed on a label paper, and the label paper is attached to the dispensing component.

[0057] The sample analyzer provided by the application has the following advantages: the sample dispensing device is provided as a first sample dispensing assembly and a second sample dispensing assembly, the first sample dispensing assembly and the second sample dispensing assembly are provided as dispensing assemblies in which at least part of components can independently perform the sample dispensing action, and at least part of components of at least one of the first sample dispensing assembly and the second sample dispensing assembly is associated with a sample addition correction parameter, that is, at least part of components of at least one of the first sample dispensing assembly and the second sample dispensing assembly is calibrated in advance and obtains the sample addition correction parameter, and the sample addition correction parameter is associated with the corresponding component, so that when the component is loaded into the sample analyzer, the sample dispensing amount of the first sample dispensing assembly in the sample dispensing action and / or the sample dispensing amount of the second sample dispensing assembly in the sample dispensing action can be corrected by directly obtaining the sample addition correction parameter of the component, thereby reducing the accuracy difference of the sample dispensing amount of the first sample dispensing assembly and the second sample dispensing assembly, and further meeting the requirement that the whole machine does not need to perform the sample addition calibration process and can meet the consistency requirement of the sample dispensing amount of the multiple samples, thereby making it possible to meet the accuracy requirement of the sample dispensing amount and the precision requirement of the clinical detection item when the first sample dispensing assembly and the second sample dispensing assembly perform the sample dispensing action of the same detection item of two samples, and further making it possible to improve the detection efficiency of the sample analyzer by fully utilizing the first sample needle and the second sample needle, and effectively avoiding the phenomenon that one sample needle is too busy and the other sample needle is idle. BRIEF DESCRIPTION OF DRAWINGS

[0058] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description only show some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from the structures shown in the drawings without creative labor.

[0059] Figure 1 is a schematic diagram of the sample analyzer provided by the first embodiment of the present application;

[0060] Figure 2 is a structural schematic diagram of the sample analyzer provided by the first embodiment of the present application;

[0061] Figure 3is a liquid path schematic view of the first sample dispensing assembly provided by the embodiment one of the present application;

[0062] Figure 4 is a liquid path schematic view of the second sample dispensing assembly provided by the embodiment one of the present application;

[0063] Figure 5 is an operation flow schematic view of the sample dispensing device after a failure occurs;

[0064] Figure 6 is a liquid path schematic view of the sample dispensing device provided by the embodiment three of the present application.

[0065] BRIEF DESCRIPTION OF DRAWINGS 10, sample analyzer; 100, sample dispensing device; 110, first sample dispensing assembly; 111, first sample needle; 112, first suction and injection power component; 113, first cleaning driving component; 114, third cleaning control valve; 115, first liquid path; 116, first cleaning control valve; 117, first sample adding control valve; 118, third liquid path; 119, fourth liquid path; 120, second sample dispensing assembly; 121, second sample needle; 122, second suction and injection power component; 123, second cleaning driving component; 124, fourth cleaning control valve; 125, second liquid path; 126, second cleaning control valve; 127, second sample adding control valve; 128, fifth liquid path; 129, sixth liquid path; 200, reagent dispensing device; 210, first reagent dispensing assembly; 220, second reagent dispensing assembly; 300, detection device; 400, controller; 500, magnetic separation device; 600, sample management device; 700, sample conveying device; 800, reagent storage device; 900, reaction device; 101, substrate dispensing device; 102, reaction container providing device; 103, reaction container recycling device; 104, transfer device; 105, information acquisition component; 20, first cleaning liquid supply device. DETAILED DESCRIPTION

[0066] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative labor fall within the protection scope of the present application.

[0067] In addition, the technical solutions in each embodiment can be combined with each other, but it must be based on that a person of ordinary skill in the art can realize.

[0068] The embodiment of the present invention is applicable to a sample analyzer that needs to pipette the same target liquid through at least two pipettes. The target liquid includes but is not limited to samples, reagents, etc.

[0069] Example 1:

[0070] like Figures 1 to 5 As shown, a sample analyzer 10 provided in a first embodiment of the present invention includes a sample dispensing device 100 and a detection device 300. The sample dispensing device 100 is configured to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container. The reaction container provides a reaction site for the sample. The detection device 300 is configured to perform the following detection actions: testing a test fluid composed of at least the sample.

[0071] As an embodiment, the sample dispensing device 100 includes a first sample dispensing component 110 and a second sample dispensing component 120. The first sample dispensing component 110 and the second sample dispensing component 120 are respectively used to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container. The first sample dispensing component 110 and the second sample dispensing component 120 are two dispensing components whose at least some components can independently perform the sample dispensing action. The first sample dispensing component 110 and the second sample dispensing component 120 share at least some components and at least some components are not shared. In this embodiment, the first sample dispensing component 110 and the second sample dispensing component 120 can both be used to perform the sample dispensing action. In this way, when a batch of samples need to be detected by the sample analyzer 10, the first sample dispensing component 110 can perform the sample dispensing action for a portion of the samples, and the second sample dispensing component 120 can perform the sample dispensing action for another portion of the samples, thereby improving the distribution efficiency of the batch samples and further improving the detection efficiency of the entire machine.

[0072] As an embodiment, the sample analyzer 10 further includes a controller 400 , which is configured to at least control the operation of the first sample dispensing component 110 , the second sample dispensing component 120 , and the detection device 300 .

[0073] As an implementation, at least part of components of at least one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 is associated with a sample addition correction parameter. The sample analyzer 10 further comprises an information acquisition component 105 configured to acquire the sample addition correction parameter of the first sample dispensing assembly 110 and / or the sample addition correction parameter of the second sample dispensing assembly 120. The controller 400 is configured to: acquire the sample addition correction parameter of the first sample dispensing assembly 110 and / or the sample addition correction parameter of the second sample dispensing assembly 120 according to the information fed back by the information acquisition component 105; and correct the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action and / or the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action according to the sample addition correction parameter of the first sample dispensing assembly 110 and / or the sample addition correction parameter of the second sample dispensing assembly 120. When the component associated with the sample addition correction parameter is applied to the sample analyzer 10, the sample addition correction parameter can be directly acquired for correction without the need of performing the sample addition calibration process on the sample analyzer 10. In the present embodiment, at least part of components of at least one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 is calibrated in advance to obtain the sample addition correction parameter, and the sample addition correction parameter is associated with the corresponding component. Thus, when the component is loaded into the sample analyzer 10, the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action and / or the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action can be corrected by directly acquiring the sample addition correction parameter of the component, thereby facilitating to reduce the accuracy difference of the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, and further meeting the requirement that the whole machine does not need to perform the sample addition calibration process to meet the consistency of the sample dispensing amount of multiple samples, thereby facilitating to meet the accuracy requirement of the sample dispensing amount and the precision requirement of the clinical detection item detection when the first sample dispensing assembly 110 and the second sample dispensing assembly 120 perform the sample dispensing action of the same detection item of two samples, and further facilitating to improve the detection efficiency of the sample analyzer 10 by fully utilizing the first sample needle 111 and the second sample needle 121, and effectively avoiding the undesirable phenomenon that one sample needle is too busy and the other sample needle is idle. In addition, in the present application, the calibration of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 is performed in advance by components rather than the whole machine of the sample analyzer 10, so that the first sample dispensing assembly 110 and the second sample dispensing assembly 120 are exempted from performing the sample addition calibration process again after being loaded into the machine, and do not need to be calibrated respectively for different clinical detection items or be allocated with different detection items, thereby saving the calibration cost and improving the detection efficiency of the sample analyzer 10.

[0074] As an implementation, at least part of components of at least one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 is configured with an identification code, and the identification code is associated with the sample addition correction parameter of the component; the information acquisition component 105 obtains the sample addition correction parameter of the first sample dispensing assembly 110 and / or the sample addition correction parameter of the second sample dispensing assembly 120 by identifying the identification code. The identification code includes at least one of a bar code, a two-dimensional code, and a radio frequency code. In this implementation, the sample addition correction parameters of at least part of components of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 are obtained by scanning the codes, so as to correct the sample dispensing amount of the first sample dispensing assembly 110 and / or the second sample dispensing assembly 120, thereby realizing rapid calibration of the first sample dispensing assembly 110 and / or the second sample dispensing assembly 120, and the method of identifying the sample addition correction parameters greatly simplifies the complexity of manual operation. When the dispensing assembly and the dispensing component are replaced, the sample addition correction parameters can be directly configured by scanning the codes, which greatly increases the replaceability and calibration convenience of the assembly and the component.

[0075] As an implementation, a label paper is pasted on at least part of components of at least one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, and the label paper is provided with an identification code. The identification code is fixed on the component by pasting, which is convenient to operate.

[0076] As an implementation, the first sample dispensing assembly 110 includes a first suction component, and the second sample dispensing assembly 120 includes a second suction component. The first suction component and the second suction component are two suction components capable of independently performing sample dispensing actions. At least one of the first suction component and the second suction component is associated with a sample addition correction parameter. In this implementation, at least one of the first suction component and the second suction component is associated with a sample addition correction parameter. When the suction component associated with the sample addition correction parameter is loaded on the sample analyzer 10, the sample addition correction parameter of the suction component can be obtained by the information acquisition component 105, and the sample dispensing amount of the sample dispensing assembly in the sample dispensing action is corrected according to the sample addition correction parameter of the suction component, without the need to perform a sample calibration process on the whole machine.

[0077] As an implementation, the first pipetting component is associated with first pipetting component sample dispensing correction parameters, the second pipetting component is associated with second pipetting component sample dispensing correction parameters, and the first pipetting component sample dispensing correction parameters and the second pipetting component sample dispensing correction parameters take the same target value as the sample dispensing correction reference. The target value can be the target dispensing amount of sample actually required by the sample dispensing device 100 to dispense to the reaction container in the sample dispensing action of one detection item, or the target value can also have a preset difference with the target dispensing amount of sample actually required by the sample dispensing device 100 to dispense to the reaction container in the sample dispensing action of one detection item. In this embodiment, the first pipetting component and the second pipetting component are respectively corrected in advance based on the same target value, so as to achieve the purpose of reducing the difference in dispensing accuracy between the first pipetting component and the second pipetting component.

[0078] As an implementation, the first pipetting component is configured with a first identification code, the first identification code is associated with first pipetting component sample dispensing correction parameters, the information acquisition component 105 is configured to identify the first identification code, and the controller 400 is further configured to: acquire the first pipetting component sample dispensing correction parameters according to the information fed back by the information acquisition component 105 identifying the first identification code; and correct the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action at least according to the first pipetting component sample dispensing correction parameters, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to the first preset value. In this embodiment, the first pipetting component is provided with a first identification code, and when the first pipetting component is loaded into the sample analyzer 10, the first pipetting component sample dispensing correction parameters can be obtained by scanning the code, and the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action is corrected according to the first pipetting component sample dispensing correction parameters, without the need to perform a sample dispensing calibration process on the whole machine.

[0079] As an implementation, the second pipetting component is configured with a second identification code, the second identification code is associated with sample loading correction parameters of the second pipetting component, the information acquisition component 105 is configured to identify the second identification code, and the controller 400 is further configured to: according to the information fed back by the information acquisition component 105 identifying the second identification code, acquire the sample loading correction parameters of the second pipetting component, and correct the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action according to at least the sample loading correction parameters of the second pipetting component, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to the first preset value. In the embodiment, the second pipetting component is provided with the second identification code, and when the second pipetting component is loaded on the sample analyzer 10, the sample loading correction parameters of the second pipetting component can be obtained by scanning the code, and the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action is corrected according to the sample loading correction parameters of the second pipetting component, without the need to perform a sample loading calibration process on the whole machine.

[0080] As an implementation, the first pipetting component is configured with a first identification code, the first identification code is associated with sample loading correction parameters of the first pipetting component, and the controller 400 is further configured to: before controlling the first pipetting component to perform a first sample dispensing action on the sample analyzer 10, acquire the sample loading correction parameters of the first pipetting component according to the information fed back by the information acquisition component 105 identifying the first identification code. Before the first pipetting component performs a first sample dispensing action on the sample analyzer 10, it can be that the sample analyzer 10 is first installed in an application scenario and the first pipetting component performs a first sample dispensing action before the first pipetting component is replaced after the sample analyzer 10 is used for a period of time. In specific applications, when the first pipetting component fails or is damaged, a calibrated pipetting component with an identification code can be re-issued as a new first pipetting component to replace the old first pipetting component on the sample analyzer 10. After the first sample dispensing assembly 110 is replaced and the sample dispensing parameters of the first sample dispensing assembly 110 are configured, the multi-sample needle system can continue to jointly dispense samples.

[0081] As an implementation, the first pipetting component is configured with a first identification code, the first identification code is associated with sample addition correction parameters of the first pipetting component, and the controller 400 is further configured to: when the first pipetting component is replaced or when the first pipetting component is first assembled on the sample analyzer 10, obtain the sample addition correction parameters of the first pipetting component according to the information fed back by the information acquisition component 105 identifying the first identification code. When the first pipetting component is first assembled on the sample analyzer 10, i.e., when the sample analyzer 10 is first installed, the sample addition correction parameters of the first pipetting component can be obtained by scanning the code, so as to correct the sample distribution amount of the first sample dispensing assembly 110, so that the first pipetting component can be exempted from performing the sample addition calibration process again after being installed, and additional clinical test item calibration or allocation of different test items to different pipetting components is not required, thereby saving calibration cost, and the method of identifying the sample addition correction parameters greatly simplifies the complexity of manual operation. In specific applications, when the first pipetting component fails or is damaged, a calibrated pipetting component with an identification code can be obtained as a new first pipetting component to replace the old first pipetting component on the sample analyzer 10, and after the sample distribution parameters of the first sample dispensing assembly 110 are configured again after being installed, the multi-sample needle system can continue to be used to jointly distribute samples.

[0082] As an implementation, the second pipetting component is configured with a second identification code, the second identification code is associated with sample addition correction parameters of the second pipetting component, and the controller 400 is further configured to: before controlling the second pipetting component to perform a first sample dispensing action on the sample analyzer 10, obtain the sample addition correction parameters of the second pipetting component according to the information fed back by the information acquisition component 105 identifying the second identification code. Before the second pipetting component performs a first sample dispensing action on the sample analyzer 10, it can be that the sample analyzer 10 is first installed in an application scenario and before the second pipetting component performs a first sample dispensing action, or it can be that the sample analyzer 10 is used for a period of time and the second pipetting component is replaced, and before the replaced second pipetting component performs a first sample dispensing action. In specific applications, when the second pipetting component fails or is damaged, a calibrated pipetting component with an identification code can be obtained as a new second pipetting component to replace the old second pipetting component on the sample analyzer 10, and after the sample distribution parameters of the second sample dispensing assembly 120 are configured again after being installed, the multi-sample needle system can continue to be used to jointly distribute samples.

[0083] As an implementation form, the second pipetting component is configured with a second identification code, the second identification code is associated with the sample addition correction parameter of the second pipetting component, and the controller 400 is further configured to: when the second pipetting component is replaced or when the second pipetting component is first assembled on the sample analyzer 10, obtain the sample addition correction parameter of the second pipetting component according to the information fed back by the information acquisition component 105 identifying the second identification code. When the sample analyzer 10 is first installed, the sample addition correction parameter of the second pipetting component can be obtained through the code scanning mode when the second pipetting component is first assembled on the sample analyzer 10, so as to correct the sample distribution amount of the second sample dispensing assembly 120, so that the second pipetting component can be exempted from performing the sample addition calibration process again after being installed, and additional clinical test item calibration or allocation of different test items to different pipetting components is not required, thereby saving calibration cost, and the method of identifying the sample addition correction parameter greatly simplifies the complexity of manual operation. In specific applications, when the second pipetting component fails or is damaged, a calibrated pipetting component with an identification code can be obtained as a new second pipetting component to replace the old second pipetting component on the sample analyzer 10. After the sample distribution parameter of the second sample dispensing assembly 120 is configured again after the replacement and installation, the multi-sample needle system can continue to jointly distribute samples.

[0084] As an implementation form, the first pipetting component includes a first sample needle 111, and the second pipetting component includes a second sample needle 121, that is, the first sample dispensing assembly 110 includes the first sample needle 111, and the second sample dispensing assembly 120 includes the second sample needle 121. The first sample needle 111 and the second sample needle 121 are two sample needles capable of independently performing sample distribution actions. At least one of the first sample needle 111 and the second sample needle 121 is associated with a sample addition correction parameter. In this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 do not share a sample needle, so that at least two sample needles of the sample distribution device 100 can work at the same time (here, working at the same time can mean that the two sample needles perform the same action at the same time, or one sample needle performs one action and the other sample needle performs another action), thereby facilitating improvement of batch sample distribution efficiency. In addition, since at least one of the first sample needle 111 and the second sample needle 121 is associated with a sample addition correction parameter, at least one of the first sample needle 111 and the second sample needle 121 can be exempted from on-machine correction.

[0085] As an implementation form, the first sample needle 111 and the second sample needle 121 are two different sample needles. Here, different sample needles mainly refer to different needles, rather than different shapes and sizes of the two needles. On the contrary, the shapes and sizes of the two needles can be the same.

[0086] As an implementation, the first sample needle 111 is configured with a first identification code, and the first identification code is associated with the sample loading correction parameter of the first sample needle 111. The information acquisition component 105 is configured to identify the first identification code; the controller 400 is further configured to: acquire the sample loading correction parameter of the first sample needle 111 according to the information fed back by the information acquisition component 105 in identifying the first identification code; and correct the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action according to at least the sample loading correction parameter of the first sample needle 111, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to the first preset value. In the embodiment, the first sample needle 111 is provided with the first identification code, and when the first sample needle 111 is loaded on the sample analyzer 10, the sample loading correction parameter of the first sample needle 111 can be obtained by scanning the code, and the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action is corrected according to the sample loading correction parameter of the first sample needle 111, without the need to perform the sample loading calibration process on the first sample needle 111 in the whole machine.

[0087] As an implementation, the controller 400 is further configured to: before controlling the first sample needle 111 to perform the first sample dispensing action on the sample analyzer 10, acquire the sample loading correction parameter of the first sample needle 111 according to the information fed back by the information acquisition component 105 in identifying the first identification code.

[0088] As an implementation, the second sample needle 121 is configured with a second identification code, and the second identification code is associated with the sample loading correction parameter of the second sample needle 121; the information acquisition component 105 is configured to identify the second identification code; and the controller 400 is further configured to: acquire the sample loading correction parameter of the second sample needle 121 according to the information fed back by the information acquisition component 105 in identifying the second identification code; and correct the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action according to at least the sample loading correction parameter of the second sample needle 121, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to the first preset value. In the embodiment, the second sample needle 121 is provided with the second identification code, and when the second sample needle 121 is loaded on the sample analyzer 10, the sample loading correction parameter of the second sample needle 121 can be obtained by scanning the code, and the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action is corrected according to the sample loading correction parameter of the second sample needle 121, without the need to perform the sample loading calibration process on the second sample needle 121 in the whole machine.

[0089] As an implementation, the controller 400 is further configured to: before controlling the second sample needle 121 to perform the first sample dispensing action on the sample analyzer 10, acquire the sample dispensing correction parameter of the second sample needle 121 according to the information identified by the information acquisition component 105 in response to the feedback of the second identification code.

[0090] As an implementation, the first suction component is a first suction power component 112 configured to provide driving force for the first sample needle 111 to perform the suction action, and the second suction component is a second suction power component 122 configured to provide driving force for the second sample needle 121 to perform the suction action. That is, the first sample dispensing assembly 110 includes the first sample needle 111 and the first suction power component 112, and the second sample dispensing assembly 120 includes the second sample needle 121 and the second suction power component 122. The first suction power component 112 and the second suction power component 122 are two suction power components that can independently perform sample dispensing actions. At least one of the first suction power component 112 and the second suction power component 122 is associated with a sample dispensing correction parameter. In this embodiment, the first sample dispensing assembly 110 and the second sample dispensing assembly 120 do not share a suction power component, and because at least one of the first suction power component 112 and the second suction power component 122 is associated with a sample dispensing correction parameter, at least one of the first suction power component 112 and the second suction power component 122 can be exempted from on-machine correction.

[0091] As an implementation, the first suction power component 112 is configured with an identification code associated with the sample dispensing correction parameter of the first suction power component 112. The information acquisition component 105 is configured to identify the identification code of the first suction power component 112, and the controller 400 is further configured to: acquire the sample dispensing correction parameter of the first suction power component 112 according to the information identified by the information acquisition component 105 in response to the feedback of the identification code of the first suction power component 112; and correct the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action according to the sample dispensing correction parameter of the first suction power component 112, so that the deviation between the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to a first preset value. In this embodiment, the first suction power component 112 is provided with an identification code. When the first suction power component 112 is loaded on the sample analyzer 10, the sample dispensing correction parameter of the first suction power component 112 can be obtained by scanning the code, and the sample dispensing amount of the first sample dispensing assembly 110 in performing the sample dispensing action can be corrected according to the sample dispensing correction parameter of the first suction power component 112, without the need to perform sample dispensing calibration on the whole machine.

[0092] As an implementation, the controller 400 is further configured to, before controlling the first pipetting power component 112 to perform the first sample dispensing action on the sample analyzer 10, acquire the sample dispensing correction parameter of the first pipetting power component 112 according to the information fed back by the information acquisition component 105 identifying the identification code of the first pipetting power component 112.

[0093] As an implementation, the second pipetting power component 122 is configured with an identification code associated with the sample dispensing correction parameter of the second pipetting power component 122. The information acquisition component 105 is configured to identify the identification code of the second pipetting power component 122, and the controller 400 is further configured to acquire the sample dispensing correction parameter of the second pipetting power component 122 according to the information fed back by the information acquisition component 105 identifying the identification code of the second pipetting power component 122, and correct the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action according to the sample dispensing correction parameter of the second pipetting power component 122, so that the deviation of the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to the first preset value. In this embodiment, the second pipetting power component 122 is provided with an identification code, and when the second pipetting power component 122 is loaded on the sample analyzer 10, the sample dispensing correction parameter of the second pipetting power component 122 can be obtained by scanning the code, and the sample dispensing amount of the second sample dispensing assembly 120 in performing the sample dispensing action is corrected according to the sample dispensing correction parameter of the second pipetting power component 122, without the need to perform a sample dispensing calibration process on the whole machine.

[0094] As an implementation, the controller 400 is further configured to, before controlling the second pipetting power component 122 to perform the first sample dispensing action on the sample analyzer 10, acquire the sample dispensing correction parameter of the second pipetting power component 122 according to the information fed back by the information acquisition component 105 identifying the identification code of the second pipetting power component 122.

[0095] As an implementation, the controller 400 is configured to control the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to perform the sample dispensing action of the same detection item of two samples, respectively, so as to avoid the phenomenon that one sample dispensing assembly is too busy and the other sample dispensing assembly is idle, and fully ensure the detection efficiency of batch samples.

[0096] As an implementation form, the deviation of the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is less than or equal to a first preset value, the first preset value is greater than or equal to zero and less than or equal to 5%. In this embodiment, the deviation of the sample dispensing accuracy of the first sample dispensing assembly 110 and the sample dispensing accuracy of the second sample dispensing assembly 120 is reduced mainly by the way that the first sample dispensing assembly 110 shares part of components with the second sample dispensing assembly 120, so that the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action and the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action are basically consistent, thereby facilitating to reduce the influence on the sample detection result when the first sample dispensing assembly 110 and the second sample dispensing assembly 120 respectively perform the sample dispensing action, and further facilitating to ensure the accuracy of the detection result when the first sample needle 111 and the second sample needle 121 perform the sample dispensing action for the same detection item.

[0097] As an implementation form, the first preset value is less than or equal to 2%, so that the difference between the sample dispensing amount of the first sample dispensing assembly 110 in the sample dispensing action and the sample dispensing amount of the second sample dispensing assembly 120 in the sample dispensing action is further reduced, thereby facilitating to ensure the consistency of the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, and further facilitating to further ensure the accuracy of the detection result when the first sample needle 111 and the second sample needle 121 perform the sample dispensing action for the same detection item.

[0098] As an implementation form, the first sample dispensing assembly 110 further comprises a first motion power component, the first motion power component is used to drive the first sample needle 111 to move in space so as to move the first sample needle 111 to different stations, such as standby station, sample suction station, sample dispensing station, cleaning station, etc.

[0099] As an implementation form, the second sample dispensing assembly 120 further comprises a second motion power component, the second motion power component is used to drive the second sample needle 121 to move in space so as to move the second sample needle 121 to different stations, such as standby station, sample suction station, sample dispensing station, cleaning station, etc.

[0100] As an implementation form, the first sample dispensing assembly 110 further comprises a first cleaning driving component 113, the first cleaning driving component 113 is used to at least drive the cleaning liquid from the first cleaning liquid supply device 20 to flush the first sample needle 111; the second sample dispensing assembly 120 further comprises a second cleaning driving component 123, the second cleaning driving component 123 is used to at least drive the cleaning liquid from the first cleaning liquid supply device 20 to flush the second sample needle 121.

[0101] As an implementation, the first sample dispensing assembly 110 further comprises a first washing control valve 116 and a first sample adding control valve 117, the first washing control valve 116 is arranged between the first washing driving component 113 and the first sample needle 111 to control the opening and closing of the liquid path between the first washing driving component 113 and the first sample needle 111, and the first sample adding control valve 117 is arranged between the first suction driving component 112 and the first sample needle 111 to control the opening and closing of the liquid path between the first suction driving component 112 and the first sample needle 111.

[0102] As an implementation, the first sample dispensing assembly 110 further comprises a third liquid path 118 and a fourth liquid path 119, the third liquid path 118 is connected between the first washing driving component 113 and the first sample needle 111, and the fourth liquid path 119 is connected between the first suction driving component 112 and the first sample needle 111, the first washing control valve 116 is arranged on the third liquid path 118 to control the opening and closing of the third liquid path 118, and the first sample adding control valve 117 is arranged on the fourth liquid path 119 to control the opening and closing of the fourth liquid path 119.

[0103] As an implementation, the second sample dispensing assembly 120 further comprises a second washing control valve 126 and a second sample adding control valve 127, the second washing control valve 126 is arranged between the second washing driving component 123 and the second sample needle 121 to control the opening and closing of the liquid path between the second washing driving component 123 and the second sample needle 121, and the second sample adding control valve 127 is arranged between the first suction driving component 112 and the second sample needle 121 to control the opening and closing of the liquid path between the first suction driving component 112 and the second sample needle 121.

[0104] As an implementation, the second sample dispensing assembly 120 further comprises a fifth liquid path 128 and a sixth liquid path 129, the fifth liquid path 128 is connected between the second washing driving component 123 and the second sample needle 121, and the sixth liquid path 129 is connected between the first suction driving component 112 and the second sample needle 121, the second washing control valve 126 is arranged on the fifth liquid path 128 to control the opening and closing of the fifth liquid path 128, and the second sample adding control valve 127 is arranged on the sixth liquid path 129 to control the opening and closing of the sixth liquid path 129.

[0105] As an implementation, the first washing driving component 113 and the second washing driving component 123 can be the same component or two different components, that is, the first sample needle 111 and the second sample needle 121 can share the washing power source or can not share the washing power source.

[0106] As an implementation, the first sample dispensing assembly 110 further comprises a third cleaning control valve 114 and a first liquid path 115 connected between the first cleaning driving component 113 and the first suction and dispensing power component 112, the first cleaning driving component 113 being used at least for driving the cleaning liquid from the first cleaning liquid supply device 20 to flow towards the first liquid path 115, and the third cleaning control valve 114 being arranged on the first liquid path 115 for controlling the opening and closing of the first liquid path 115; the second sample dispensing assembly 120 further comprises a fourth cleaning control valve 124 and a second liquid path 125 connected between the second cleaning driving component 123 and the first suction and dispensing power component 112, the second cleaning driving component 123 being used at least for driving the cleaning liquid from the first cleaning liquid supply device 20 to flow towards the second liquid path 125, and the fourth cleaning control valve 124 being arranged on the second liquid path 125 for controlling the opening and closing of the second liquid path 125. The third cleaning control valve 114 and the fourth cleaning control valve 124 can be the same component, or can be two components for independently controlling the opening and closing of the liquid paths. The first liquid path 115 and the second liquid path 125 can be the same liquid path, or can be two parallel liquid paths.

[0107] After analysis, in the multi-sample needle system, the main factors affecting the accuracy difference of the multi-sample needle system are the suction and dispensing power component and the sample needle, in which the suction and dispensing power component accounts for more than 70%, and the sample needle accounts for more than 25%. In order to reduce the sample dispensing amount difference caused by the difference between the suction and dispensing power component and the sample needle, the embodiment designs a method of correcting the suction and dispensing power component and the sample needle in advance, so that they can reach the target sample dispensing amount, and can scan and configure the sample dispensing parameters, so that the first sample dispensing assembly 110 and the second sample dispensing assembly 120 and their components can be exempted from the sample calibration process after being put on the machine. The method of calibrating the suction and dispensing power component and the sample needle can reduce the accuracy difference of the multi-sample needle system by more than 95%, and after calculation, it can directly meet the precision requirements of sample dispensing and clinical detection projects, and does not need to be calibrated separately or allocated to different detection projects for different sample needles, which can save calibration cost and improve the detection efficiency of the sample analyzer 10. Of course, in specific applications, it is not limited to the pre-calibration of the identification code of the suction and dispensing power component and the sample needle, and other components of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 can also be pre-corrected, such as the first movement power component, the second movement power component, the first cleaning driving component 113, the second cleaning driving component 123, the first cleaning control valve 116, the first sample control valve 117, the second cleaning control valve 126, the second sample control valve 127, the third cleaning control valve 114, and the fourth cleaning control valve 124.

[0108] As an implementation, the sample analyzer 10 further comprises a reaction device 900 for carrying the reaction container to incubate a sample and a reagent in the reaction container.

[0109] As an implementation, the sample analyzer 10 further comprises a reagent dispensing device 200 for performing a reagent dispensing action of aspirating a reagent from a reagent container and dispensing at least part of the aspirated reagent into a reaction container. The reaction device 900 is for carrying the reaction container to perform an incubation action of incubating a liquid containing at least a sample and a reagent. The detection device 300 is for performing a detection action on a to-be-detected liquid made of at least a sample dispensed by the sample dispensing device 100 and a reagent dispensed by the reagent dispensing device 200. The sample analyzer 10 of the present implementation is suitable for a scenario where the reagent is dispensed by the reagent dispensing device 200 into the reaction container; of course, as an alternative implementation, the sample analyzer 10 can also be configured without the reagent dispensing device 200, which is suitable for a scenario where the reagent is pre-stored in the reaction container.

[0110] As an implementation, the reagent dispensing device 200 comprises a first reagent dispensing assembly 210, which comprises a first reagent needle and a reagent dispensing power component (i.e., a third dispensing power component) for driving the first reagent needle to aspirate a reagent from a reagent container and to dispense at least part of the aspirated reagent into a reaction container.

[0111] As an implementation, the sample analyzer 10 further comprises a reagent storage device 800 for storing a reagent container, and the reagent dispensing device 200 is configured to aspirate a reagent from the reagent container at the reagent aspiration position in the reagent storage device 800. Of course, as an alternative implementation, the reagent storage device 800 can also be configured not to be arranged in the sample analyzer 10, for example, by placing the reagent container at the reagent aspiration position by an operator.

[0112] As an implementation, the controller 400 is configured to perform a first detection procedure as follows: control the first sample dispensing assembly 110 to perform a sample dispensing action, control the reagent dispensing device 200 to perform a reagent dispensing action, control the detection device 300 to detect a to-be-tested liquid made of at least a sample dispensed by the first sample dispensing assembly 110 and a reagent dispensed by the reagent dispensing device 200, obtain first detection data according to detection information fed back by the detection device 300, and obtain a first detection result according to the first detection data and first calibration data. The controller 400 is also configured to perform a second detection procedure as follows: control the second sample dispensing assembly 120 to perform a sample dispensing action, control the reagent dispensing device 200 to perform a reagent dispensing action, control the detection device 300 to detect a to-be-tested liquid made of at least a sample dispensed by the second sample dispensing assembly 120 and a reagent dispensed by the reagent dispensing device 200, obtain second detection data according to detection information fed back by the detection device 300, and obtain a second detection result according to the second detection data and second calibration data. The difference between the first detection procedure and the second detection procedure mainly lies in the sample dispensing assembly used to perform the sample dispensing action, specifically embodied in that the sample dispensing action of the first detection procedure is performed by the first sample dispensing assembly 110, and the sample dispensing action of the second detection procedure is performed by the second sample dispensing assembly 120.

[0113] As an implementation, the controller 400 is also configured to: control the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to respectively perform sample dispensing actions of the same detection item of two samples, control the same reagent dispensing device 200 to respectively perform reagent dispensing actions of the same detection item of the two samples, control the same reaction device 900 to respectively perform incubation actions of the same detection item of the two samples, and control the same detection device 300 to respectively detect to-be-tested liquids made of the two samples and reagents. In this implementation, the first detection procedure and the second detection procedure share the reagent dispensing device 200, the reaction device 900, and the detection device 300, which helps to ensure the consistency of the reagent system, the reaction system, and the detection system in the first detection procedure and the second detection procedure. In this way, as long as the sample amount dispensing difference of the sample dispensing system (i.e., the first sample dispensing assembly 110 and the second sample dispensing assembly 120) is reduced, the consistency of the detection result can be ensured.

[0114] As an implementation, the reaction device 900 comprises a first reaction disc for carrying the reaction container to incubate the sample and reagent. The detection device 300 comprises a first light receiving component for optical detection of the to-be-tested liquid in the reaction container. The controller 400 is further configured to: control the same reagent suction power component (i.e., the third suction power component) to drive the same first reagent needle to perform the reagent dispensing action of the first detection process and the reagent dispensing action of the second detection process, respectively; control the same first reaction disc to incubate the sample and reagent in the first detection process and the sample and reagent in the second detection process; and control the same first light receiving component to perform optical detection of the first detection process and optical detection of the second detection process, respectively. In this implementation, the first detection process and the second detection process share the reagent needle, the reagent suction power component, the first reaction disc, and the first light receiving component, which helps to ensure the consistency of the reagent system, the reaction system, and the detection system in the first detection process and the second detection process.

[0115] As an implementation, the sample analyzer 10 further comprises a magnetic separation device 500 and a substrate dispensing device 101. The reagent dispensing device 200 performs a reagent dispensing action, which includes: sucking the magnetic bead reagent from the first reagent container and dispensing it into the reaction container, and sucking the marker reagent from the second reagent container and dispensing it into the reaction container. The reaction device 900 is used to carry the reaction container to perform an incubation action, which includes: incubating at least the sample, the magnetic bead reagent, and the marker reagent to prepare a first reaction liquid. The magnetic separation device 500 is used to perform a magnetic separation and washing operation on the first reaction liquid to prepare a second reaction liquid. The substrate dispensing device 101 is used to perform a substrate dispensing action, which includes: sucking the luminescent substrate reagent from the substrate reagent container, and dispensing at least part of the sucked luminescent substrate reagent into the reaction container loaded with the second reaction liquid to prepare the to-be-tested liquid from the second reaction liquid and the luminescent substrate reagent. The detection device 300 is used to detect the luminescent intensity of the to-be-tested liquid. The magnetic bead reagent is a reagent containing magnetic beads. The marker reagent is an antibody reagent with a luminescent marker or an antigen reagent with a luminescent marker. Before the magnetic separation and washing operation is performed, the sample and the reagent first perform an antigen and antibody binding reaction. During the magnetic separation and washing process, operations such as magnetic adsorption, liquid suction, addition of separation liquid, mixing, and incubation are performed. The magnetic separation and washing operation is mainly used to wash away the impurities in the first reaction liquid, while retaining part of the to-be-tested liquid to obtain a purified second reaction liquid. The liquid processed by the magnetic separation device 500 includes a clear liquid and a magnetic bead liquid. In an implementation, the clear liquid is treated as waste liquid, and the magnetic bead liquid forms the second reaction liquid. In this implementation, the magnetic bead reagent and the marker reagent are two reagents separately packaged in two reagent containers. Of course, in specific applications, as an alternative implementation, the magnetic bead reagent and the marker reagent can be integrated into a reagent packaged in the same reagent container.

[0116] As an implementation, the substrate dispensing device 101 is used to perform the substrate dispensing action on the reaction container located in the magnetic separation device 500, and the substrate dispensing device 101 and the reagent dispensing device 200 are two different dispensing devices. Of course, in specific applications, as an alternative implementation, the reagent dispensing device 200 can also be used to perform the substrate dispensing action on the reaction container located in the reaction device 900, that is, the substrate dispensing device 101 and the reagent dispensing device 200 can also be the same dispensing device.

[0117] As an implementation, the controller 400 is further configured to control the same magnetic separation device 500 to perform the magnetic separation cleaning operation of the same detection item of the two samples respectively, and control the same substrate dispensing device 101 to perform the substrate dispensing action of the same detection item of the two samples respectively. In this implementation, the first detection process and the second detection process share the magnetic separation device 500 and the substrate dispensing device 101 in addition to the reagent dispensing device 200, the reaction device 900 and the sample detection device 300, which helps to ensure the consistency of the reagent system, the reaction system, the magnetic separation system, the substrate system and the detection system in the first detection process and the second detection process, effectively avoiding the influence of the reagent system, the reaction system, the magnetic separation system, the substrate system and the detection system on the detection result. In this way, as long as the sample dispensing system is consistent, the consistency of the detection result can be ensured.

[0118] As an implementation, the reagent suction and injection power component (i.e., the third reagent suction and injection power component) is configured to drive the first reagent needle to suction the magnetic bead reagent containing magnetic beads from the first reagent container and dispense the magnetic bead reagent into the reaction container, and to drive the first reagent needle to suction the label reagent containing enzyme from the second reagent container and dispense the label reagent into the reaction container. The first reaction disc is configured to incubate the sample, the magnetic bead reagent, and the label reagent. The magnetic separation device 500 is configured to perform a magnetic separation and washing action on the liquid in the reaction container after at least the sample, the magnetic bead reagent, and the label reagent are incubated. The substrate dispensing device 101 includes a substrate needle and a substrate suction and injection power component configured to drive the substrate needle to perform a substrate dispensing action of suctioning the luminescent substrate reagent from the substrate container and dispensing at least part of the suctioned luminescent substrate reagent into the reaction container to prepare the to-be-tested liquid. The controller 400 is further configured to: control the same reagent suction and injection power component to drive the same first reagent needle to perform the reagent dispensing action of the magnetic bead reagent in the first detection process and the reagent dispensing action of the magnetic bead reagent in the second detection process, respectively; control the same reagent suction and injection power component to drive the same first reagent needle to perform the reagent dispensing action of the label reagent in the first detection process and the reagent dispensing action of the label reagent in the second detection process, respectively; control the same first reaction disc to incubate the sample, the magnetic bead reagent, and the label reagent in the first detection process and the sample, the magnetic bead reagent, and the label reagent in the second detection process; control the same magnetic separation device 500 to perform a magnetic separation and washing action on the liquid in the reaction container after at least the sample, the magnetic bead reagent, and the label reagent are incubated in the first detection process and the second detection process; control the same substrate suction and injection power component to drive the same substrate needle to perform the substrate dispensing action in the first detection process and the substrate dispensing action in the second detection process, respectively; and control the same first light receiving component to perform optical detection in the first detection process and optical detection in the second detection process, respectively.

[0119] As an implementation, the sample analyzer 10 further includes a sample management device 600 configured to place the sample container to at least implement sample loading, and a sample conveying device 700 configured to convey the sample container output by the sample management device 600 to the sample suction position for sample dispensing by the sample dispensing device 100. The sample management device 600 can implement batch loading of sample containers, specifically, an operator or an operating robot can place a sample container loaded with a sample to the sample management device 600, and the sample management device 600 is configured to store the sample container and dispatch the sample container loaded with the sample to the sample conveying device 700. Of course, in specific applications, the sample analyzer 10 can also not be provided with the sample management device 600 and the sample conveying device 700, for example, as an alternative implementation, the sample container loaded with the sample is placed by the operator to the sample suction position for sample suction by the sample dispensing device 100.

[0120] As an implementation, the sample analyzer 10 further comprises a transfer device 104 for transferring the reaction vessels. The transfer device 104 is configured to perform at least one of the following transfer operations: transferring the sample-added reaction vessels to the reaction device 900, transferring the incubation-completed reaction vessels from the reaction device 900 to the magnetic separation device 500; transferring the magnetic separation-washed reaction vessels from the magnetic separation device 500 to the detection position for detection; transferring the detection-completed reaction vessels to the ejection position for ejection and recycling.

[0121] As an implementation, the sample analyzer 10 further comprises a reaction vessel providing device 102 and a reaction vessel recycling device 103, the reaction vessel providing device 102 is configured to provide the reaction vessels, and the reaction vessel recycling device 103 is configured to recycle the reaction vessels. The sample analyzer 10 further forms a recycling position, and the reaction vessel recycling device 103 is located below the recycling position. The transfer device 104 is configured to at least transfer the reaction vessels from the detection position to the recycling position for recycling. In this implementation, the reaction vessels are disposable vessels, i.e., a reaction vessel is recycled after completing a detection item. Of course, in specific applications, the reaction vessels can also be recycled vessels, i.e., a reaction vessel can be cleaned and reused for other detection items after completing a detection item in the sample analyzer 10.

[0122] As an implementation, the controller 400 is further configured to perform an item calibration process, including: controlling one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to draw an item calibration sample from a calibration sample container and dispense it into a reaction vessel, controlling the reagent dispensing device 200 to draw a reagent from a reagent container and dispense it into the reaction vessel; controlling the detection device 300 to detect a calibration solution at least made of the item calibration sample and the reagent in the reaction vessel, and obtaining calibration data corresponding to the sample detection item according to the detection information fed back by the detection device 300. The item calibration process is mainly used to obtain calibration data corresponding to the sample detection item, which is used to calibrate the detection information obtained in the first detection process and the second detection process to obtain the detection result. The sample analyzer 10 can be used to perform multiple different detection items, and each detection item corresponds to a calibration data. In this implementation, since the first sample dispensing assembly 110 and the second sample dispensing assembly 120 perform the same detection item and share the same calibration data, the calibration data of each sample detection item can be executed only once by one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120, without the need for the first sample dispensing assembly 110 and the second sample dispensing assembly 120 to be executed, and without the need for each clinical item to be calibrated for the first sample dispensing assembly 110 and the second sample dispensing assembly 120 respectively, effectively reducing the calibration cost of the sample analyzer 10.

[0123] As an implementation, the controller 400 is configured to perform a project calibration process of the first detection item, including: controlling the first sample dispensing assembly 110 to aspirate the project calibration sample from the calibration sample container and dispense into the reaction container, controlling the reagent dispensing device 200 to aspirate the reagent from the reagent container and dispense into the reaction container; controlling the detection device 300 to detect the calibration solution made at least from the project calibration sample and the reagent in the reaction container, and obtaining the first calibration data corresponding to the first detection item according to the detection information fed back by the detection device 300. The controller 400 is also configured to perform a second detection process of the first detection item, including: controlling the second sample dispensing assembly 120 to perform a sample dispensing action, controlling the reagent dispensing device 200 to perform a reagent dispensing action, and controlling the sample detection device 300 to detect the to-be-detected solution made at least from the sample dispensed by the second sample dispensing assembly 120 and the reagent dispensed by the reagent dispensing device 200, obtaining the second detection data according to the detection information fed back by the detection device 300, and obtaining the second detection result according to the second detection data and the first calibration data corresponding to the first detection item. In this embodiment, the second sample dispensing assembly 120 can use the calibration data obtained by the first sample dispensing assembly 110 performing the project calibration process when performing the second detection process, so that one sample detection item does not need to perform the project calibration process for both the first sample dispensing assembly 110 and the second sample dispensing assembly 120, but only needs to perform the project calibration process for one of the first sample dispensing assembly 110 and the second sample dispensing assembly 120.

[0124] As an implementation, the sample analyzer 10 pre-stores preset conditions, which at least include one of the following: a preset time length since the last execution of the item calibration process; a preset time point of a preset maintenance period; information of a newly loaded reagent container; information of a failed quality control detection result; and the controller 400 is further configured to execute the item calibration process when the preset conditions are met. When the sample analyzer 10 pre-stores at least two of the above preset conditions, the item calibration process is executed as long as any one of the preset conditions is met. The preset time length since the last execution of the item calibration process specifically refers to that after the completion of the execution of the item calibration process, the execution of the item calibration process is performed every preset time length. The preset time point of the preset maintenance period specifically refers to that the execution of the item calibration process is performed at a fixed time point, which is not associated with the interval time length of the last execution of the item calibration process. The information of the newly loaded reagent container can be obtained after the sample analyzer 10 completes the first installation in a specific application scenario, or after the sample analyzer 10 uses for a period of time and then replaces the reagent container. In this embodiment, the item calibration process is not performed during the execution of the sample detection item, which does not occupy the normal sample detection time of the sample analyzer 10, and is automatically executed according to the set program when the preset conditions are met, which is beneficial to make the operation personnel basically unaware of the execution of the item calibration process, and greatly reduces the interference of the item calibration process on the operation personnel.

[0125] As an implementation, the execution period of the item calibration process is 28 days, that is, the preset maintenance period or the preset time length is 28 days. When the reagent of a certain detection item is replaced, the item calibration process of the detection item is executed. When the quality control result of a certain detection item is wrong, the item calibration process of the detection item is executed.

[0126] As an implementation, the calibration data (including but not limited to the first calibration data) contains a plurality of sets of corresponding relationships between different known detection information and different calibration parameters. The calibration data can be a parameter of a linear function, or a calibration curve of a linear function, or a calibration database or table formed by a plurality of sets of known detection information and calibration parameters.

[0127] As an implementation, the controller 400 is further configured to execute a quality control process. The quality control process can be executed once a day, for example, once before sample detection in the morning every day. Alternatively, the quality control process can be executed twice a day, for example, once before sample detection in the morning and once before sample detection in the afternoon every day.

[0128] As an implementation, the sample analyzer 10 described above is an immunoassay analyzer. The immunoassay analyzer is used to detect immune-related parameters of a blood sample. Prior to the present application, the related art immunoassay analyzer either uses a single needle system to perform sample dispensing of all samples of the immunoassay analyzer, or uses a multi-needle system to perform sample dispensing of different detection items respectively, or uses a multi-needle system to perform sample dispensing of different samples respectively, which requires separate clinical item calibration. These solutions cannot meet the design requirements of the immunoassay analyzer for high detection efficiency, low calibration cost, and high calibration efficiency. In the immunoassay analyzer provided in the present embodiment, the first sample needle 111 and the second sample needle 121 can be used to detect the same detection item and do not need to be calibrated for the same detection item. In this way, on the one hand, the parallel work of the first sample needle 111 and the second sample needle 121 can improve the efficiency of immune detection. On the other hand, since the first sample needle 111 and the second sample needle 121 do not need to be calibrated for the same detection item, the multi-needle calibration cost of the immunoassay analyzer is reduced, and the calibration efficiency is improved. Of course, in specific applications, the type of the sample analyzer 10 is not limited to this. For example, as an alternative implementation, the sample analyzer 10 can also be a biochemical analyzer or a routine blood cell analyzer or a coagulation analyzer, etc. That is, the high-efficiency, low-cost multi-needle system of the present embodiment can be used not only in the immunoassay analyzer, but also in the biochemical analyzer or the routine blood cell analyzer or the coagulation analyzer and other analyzers.

[0129] As an implementation, the detection items performed by the immunoassay analyzer include at least an immunoassay luminescence detection item. The goal of the immunoassay luminescence detection is to detect the content of a certain specific antigen or antibody in the sample. The reaction container is used to carry out the antigen and antibody binding reaction of the sample and the reagent. The detection device 300 is used to detect the light signal of the to-be-detected liquid. Since there are various impurities in the sample, some impurities, such as endogenous enzymes contained in the blood sample, will affect the final detection system (i.e., the to-be-detected liquid to be finally detected), thereby affecting the accuracy of the detection result. Therefore, the execution process of the immunoassay luminescence detection needs to be purified for the target antigen or the target antibody, and then the level (i.e., the content) of the target antigen or the target antibody in the sample is obtained through the luminescence detection of the marker. In order to detect the level of the target antigen or the target antibody in the sample, the present embodiment converts the concentration of the target antigen or the target antibody into a physical quantity of luminescence. Since the antigen or the antibody itself does not have the ability to emit light, the conversion of light emission can be performed through the antibody with a luminescent marker or the antibody with a luminescent marker.

[0130] As an embodiment, the reaction container is used at least to provide a reaction site for the sample and the reagent, so that the target antigen in the sample and the antibody in the reagent or the target antibody in the sample and the antigen in the reagent are combined to form a first reaction solution containing at least a first antigen-antibody complex by generating an antigen-antibody binding reaction. In this embodiment, the target of at least one sample detection item is to detect the content of the target antigen (a certain specific antigen) or the target antibody (a certain specific antibody) in the sample. When the target of one sample detection item is to detect the target antigen in the sample, the sample contains the target antigen and the reagent contains the antibody, and the first antigen-antibody complex is formed by the target antigen in the sample and the antibody in the reagent through the antigen-antibody binding reaction. When the target of one sample detection item is to detect the target antibody in the sample, the sample contains the target antibody and the reagent contains the antibody, and the first antigen-antibody complex is formed by the target antibody in the sample and the antigen in the reagent through the antigen-antibody binding reaction.

[0131] In the fully automatic immune analyzer, the sample needle is responsible for completing the dispensing work of the sample to be tested. For a fully automatic immune analyzer containing two sample needles, consistent sample adding performance is required between the two sample needles. The measurement and evaluation of the difference in sample adding performance of the double sample needles is the basis for the consistency control of the double sample needles. In the double sample needle system, the consistency of the double sample needles is controlled, that is, when the double sample needles dispense the same volume of liquid, the difference between the actual volumes of the two sample needles is as small as possible.

[0132] As an embodiment, the first antigen-antibody complex contained in the first reaction solution is formed by sandwiching the antigen and the antibody. For example, if the content of the target antigen in the sample is to be detected, the magnetic bead reagent distributed by the reagent distribution device 200 carries the antibody, the marker reagent is an antibody reagent carrying a luminescent marker, and the target antigen in the sample is sandwiched between the antibody of the magnetic bead reagent and the antibody of the marker reagent. In this scheme, the cell surface of the sample has an antigen, the surface of the magnetic bead has an antibody, and the marker reagent has an antibody. The target antigen in the sample can be specifically combined with the magnetic bead carrying a specific antibody and the antibody carrying a luminescent marker, thereby forming a first antigen-antibody complex of magnetic bead-target antigen-luminescent marker antibody. If the content of the target antibody in the sample is to be detected, the magnetic bead reagent distributed by the reagent distribution device 200 carries the antigen, and the marker reagent is an antigen reagent carrying a luminescent marker.

[0133] As an embodiment, when it is necessary to detect the target antigen in the sample, the sandwich immunoluminescence detection process includes: in the initial mixing process of the sample and the reagent, the target antigen is first combined with the magnetic beads with a specific antibody, and then the target antigen is specifically bound to the antibody with a luminescent marker in the reagent, and a system of magnetic bead antibody-target antigen-luminescent marker antibody (i.e., the above-mentioned first antigen-antibody conjugate) is generated. After the system of magnetic bead antibody-target antigen-luminescent marker antibody is generated, it enters the magnetic separation and cleaning operation step. Before the magnetic separation and cleaning operation step, the reaction system contains impurities, and the magnetic separation and cleaning operation will clean out these impurities by changing the liquid and re-dispersing, while retaining the target antigen to be tested in the reaction vessel, thereby achieving the purification of the reaction solution. Finally, the second reaction solution after purification is mixed with a luminescent substrate reagent. Under the catalytic action of the luminescent marker, the luminescent substrate reagent emits light and is collected and counted by the sample detection device 300 (e.g., a photometer, etc.). The controller 400 calculates the concentration value of the corresponding target antigen based on the data fed back by the sample detection device 300, thereby obtaining the target antigen level of the corresponding sample to help make a clinical judgment.

[0134] Of course, in specific applications, the antigen-antibody binding body contained in the first reaction liquid is not limited to being formed by the combination of antigen and antibody through a sandwich method. In an alternative embodiment, the antigen-antibody binding body contained in the first reaction liquid can also be formed by the combination of antigen and antibody through a competitive method. In this alternative, the antigen-antibody binding body contained in the first reaction liquid includes: a first antigen-antibody binding body formed by the combination of the target antigen in the sample and the antibody on the surface of the magnetic beads in the magnetic bead reagent, and a second antigen-antibody binding body formed by the combination of the antigen in the marker reagent and the antibody on the surface of the magnetic beads in the magnetic bead reagent. Due to the limited number of antibodies on the magnetic beads, the target antigen in the sample and the antigen in the marker reagent form a competitive relationship, that is, the luminescence value is inversely proportional to the concentration of the target in the sample. The concentration of the target antigen in the sample can be reversely calculated through the measured luminescence value.

[0135] As an embodiment, the execution process of a detection item in the immunoassay analyzer includes: adding a sample, adding a magnetic bead reagent and a marker reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a first reaction liquid, magnetically separating and cleaning the first reaction liquid to obtain a second reaction liquid, adding a luminescent substrate reagent to the second reaction liquid to obtain a second mixed liquid, mixing and incubating the second mixed liquid to obtain a liquid to be tested, and optically measuring the liquid to be tested to obtain a detection result.

[0136] As an embodiment, the marker reagent is an alkaline phosphatase solution. In the enzyme emission system, the final emission is the chemiluminescence generated by the alkaline phosphatase-labeled antigen or antibody and the magnetic bead coating catalyzing the luminescent substrate reagent. The essence is that the alkaline phosphatase catalyzes the luminescent substrate reagent to emit light. Therefore, the alkaline phosphatase is mixed with an excess of luminescent substrate reagent to react, and the final emission intensity is positively correlated with the amount of alkaline phosphatase added. When a certain concentration of alkaline phosphatase solution is used, the final emission intensity is positively correlated with the volume of the alkaline phosphatase solution.

[0137] As an embodiment, the implementation of evaluating the volume difference of the liquid dispensed by the double-sample needle is as follows: in the immunoassay instrument, the two sample needles are controlled to dispense the same volume of alkaline phosphatase solution into the same amount of excess luminescent substrate reagent under the same working conditions. After a certain time of incubation (to ensure that the alkaline phosphatase solution and the luminescent substrate reagent are fully reacted), the photometer of the immunoassay instrument is used to measure the light of the two reaction liquids, and the emission intensity of the two reaction liquids obtained by the reaction of the alkaline phosphatase solution and the luminescent substrate reagent dispensed by the two sample needles is obtained. Then, combined with the quantitative relationship between the liquid volume dispensed by the sample needle and the emission value in the enzyme+substrate emission system, the difference in the actual liquid volume dispensed by the two sample needles is calculated. The quantitative relationship between the liquid volume dispensed by the sample needle and the emission value is the key to this method. In the enzyme+substrate reaction system, the sample delivery coefficient can be defined to reflect the quantitative relationship between the deviation of the liquid volume dispensed by the sample needle and the deviation of the final emission value: sample delivery coefficient = relative deviation of emission value / relative deviation of liquid volume dispensed by sample needle, wherein the relative deviation of the liquid volume dispensed by the sample needle is the difference in the liquid dispensing amount of the same volume of liquid dispensed by the two sample needles (i.e., the first sample needle 111 and the second sample needle 121), and the relative deviation of the emission value is the difference in the emission intensity of the two reaction liquids obtained by the reaction of the liquid dispensed by the two sample needles with the luminescent substrate reagent. The sample delivery coefficient is an inherent attribute of the quantitative relationship between the liquid volume dispensed by the sample needle and the emission value. Within a certain range of dispensing liquid volume, the sample delivery coefficient can be regarded as a constant, and the relative deviation of the liquid volume dispensed by the sample needle can be calculated as follows: relative deviation of liquid volume dispensed by sample needle = relative deviation of emission value / sample delivery coefficient.

[0138] As an embodiment, the sample dispensing device 100 is a double-sample needle system, that is, the sample needle of the sample dispensing device 100 is only the first sample needle 111 and the second sample needle 121, which can avoid the phenomenon of too complex structure and too high cost of the sample dispensing device 100 due to too many sample needles while ensuring efficiency. Of course, in specific applications, the sample dispensing device 100 is not limited to a double-sample needle system. For example, in addition to the first sample dispensing assembly 110 and the second sample dispensing assembly 120 described above, the sample dispensing device 100 can also include a third sample dispensing assembly, and the third sample dispensing assembly includes a third sample needle. The first sample needle 111, the second sample needle 121, and the third sample needle are three sample needles that can independently perform sample dispensing actions.

[0139] As an embodiment, the method for pre-correcting the first sample dispensing assembly 110 and the second sample dispensing assembly 120 and their components to eliminate the sample calibration after the machine is started includes the following steps: (1) preparing each component and part of the multi-sample needle system, such as the dispensing power component and the sample needle; (2) applying the precision measurement platform and the corresponding algorithm to the dispensing power component to correct each dispensing power component to the same target sample dispensing amount, recording the sample calibration parameters related to each dispensing power component, coding the sample calibration parameters, and pasting the coded sample calibration parameters on the corresponding dispensing power component; (3) applying the structure measurement platform and the corresponding algorithm to the sample needle to correct each sample needle to the same target sample dispensing amount, recording the sample calibration parameters related to each sample needle, coding the sample calibration parameters, and pasting the coded sample calibration parameters on the corresponding sample needle; (4) after the dispensing power component and the sample needle are assembled on the machine, the corresponding sample calibration parameters are configured by scanning the code, and after the configuration is successful, the accuracy difference of the multi-sample needle system can be basically eliminated, and the multi-sample needle joint detection can be directly performed, thereby eliminating the sample calibration process after the machine is started. The method for calibrating the dispensing power component and the sample needle can reduce the accuracy difference of the multi-sample needle system by more than 95%, and after calculation, it can directly meet the precision requirements of sample dispensing and clinical detection projects.

[0140] In this embodiment, the sample calibration parameters of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 are coded, and the parameters can be directly configured by scanning the code. When the components or parts of the multi-sample needle system fail or are damaged, especially when the dispensing power component and / or the sample needle fail or are damaged, the dispensing power component and / or the sample needle with the coded calibration parameters can be re-obtained, and after the machine is assembled and the sample dispensing parameters are re-configured by scanning the code, the multi-sample needle joint can continue to perform the sample dispensing action.

[0141] The embodiment also provides a dispensing component for dispensing a sample, the dispensing component being configured with an identification code, the identification code being associated with a pipetting correction parameter of the dispensing component, the pipetting correction parameter being used to correct a liquid dispensing amount of the dispensing component. Since the calibration of the dispensing component is performed in advance by the component, rather than by the whole machine of the sample analyzer 10, the dispensing component is exempted from performing the pipetting calibration process again after being put on the machine, and there is no need to perform separate calibration for different clinical detection items or to assign different detection items to different dispensing components, so that the calibration cost can be saved and the detection efficiency of the sample analyzer 10 can be improved.

[0142] As an implementation manner, the dispensing component is a sample needle for dispensing a sample, or a sample pipetting power component for driving the sample needle to perform a pipetting action; and / or the identification code is formed on a label paper, and the label paper is attached to the dispensing component.

[0143] The embodiment directly ensures the consistency of the sample dispensing amount from the root of the sample amount difference of the multi-sample needle system by adopting the scheme of separately calibrating the dispensing power component and the sample needle, and there is no need to separately perform a sample adding calibration process or a clinical item calibration operation, so that the precision requirement of the clinical item detection can be directly met, and the identification coding method of the sample adding correction parameter greatly simplifies the complexity of human operation. When the sample dispensing assembly and the component are replaced, the sample adding correction parameter can be directly configured by scanning the code, so that the replaceability and the replacement convenience of the multi-sample needle system are greatly increased.

[0144] Embodiment two:

[0145] The sample analyzer 10 and the dispensing component provided in the embodiment are mainly different from the embodiment one in that the setting manners of the reagent system, the reaction system and the detection system are different, and the difference is embodied in that, in the embodiment one, the reagent system, the reaction system and the detection system are shared by the first detection process and the second detection process; and in the embodiment, at least one of the reagent system, the reaction system and the detection system is not shared by the first detection process and the second detection process.

[0146] Specifically, in the embodiment, the following at least one device used in the first detection process and the second detection process is a device whose at least part of components can work independently of each other: the reagent dispensing device 200, the reaction device 900 and the detection device 300. In the embodiment, in the first detection process and the second detection process, in addition to the sample system, at least part of components are not shared, at least part of components of the reagent system, the reaction system and the detection system can also be not shared, as long as the deviation of the final detection result is within an acceptable range.

[0147] As an implementation, at least one of the devices used in the first detection process and the second detection process is two devices that can at least partially work independently and are associated with correction parameters: the reagent dispensing device 200, the reaction device 900, and the detection device 300. In this implementation, for inconsistent components in the reagent system, the reaction system, and the detection system, the correction parameter identification code can be used to make the performance of the inconsistent components consistent, for example, a component has an identification code, when the component is loaded into the sample analyzer 10, the correction parameter of the component can be obtained by scanning the code, and the component is corrected according to the correction parameter of the component, without the need to perform the calibration process on the whole machine. In this implementation, the sample system and the reagent system, the reaction system, and the detection system are corrected separately to meet the consistency requirements; of course, in specific applications, as an alternative implementation, the sample dispensing amount of the first sample dispensing assembly 110 and the second sample dispensing assembly 120 can be inconsistent, but the detection result can be consistent by correcting at least one of the reagent system, the reaction system, the detection system, for example, by synchronously correcting the reagent system and / or the reaction system to correct the detection result deviation caused by the inconsistent sample dispensing amount, to ensure the consistency of the detection result.

[0148] As an implementation, the reagent dispensing device 200 includes at least two reagent dispensing assemblies that can at least partially perform reagent dispensing actions independently and are associated with correction parameters; and / or, the sample analyzer 10 further includes a reaction device 900, which is used to carry a reaction container to perform the following incubation action: incubating a liquid containing at least a sample and a reagent; the reaction device 900 includes at least two incubation assemblies that can at least partially perform incubation actions independently and are associated with correction parameters; and / or, the detection device 300 includes at least two detection assemblies that can at least partially perform detection on the to-be-detected liquid independently and are associated with correction parameters.

[0149] As an implementation, the reagent dispensing device 200 comprises a first reagent dispensing assembly 210 and a second reagent dispensing assembly 220, the first reagent dispensing assembly 210 comprises a first reagent needle and a first reagent dispensing power component, the first reagent dispensing power component is used to drive the first reagent needle to suck reagent from a reagent container and drive the first reagent needle to dispense at least part of the sucked reagent into a reaction container, the second reagent dispensing assembly 220 comprises a second reagent needle and a second reagent dispensing power component, the second reagent dispensing power component is used to drive the second reagent needle to suck reagent from a reagent container and drive the second reagent needle to dispense at least part of the sucked reagent into a reaction container; the reaction device 900 comprises a first reaction disc and a second reaction disc, the first reaction disc and the second reaction disc are respectively used to carry a reaction container for incubating a sample and a reagent. The detection device 300 comprises a first light receiving component and a second light receiving component, the first light receiving component is used to perform optical detection on the to-be-detected liquid in the reaction container after incubation by the first reaction disc, and the second light receiving component is used to perform optical detection on the to-be-detected liquid in the reaction container after incubation by the second reaction disc. The deviation of the reagent dispensing accuracy of the first reagent dispensing assembly 210 and the reagent dispensing accuracy of the second reagent dispensing assembly 220 is less than or equal to a second preset value; the deviation of the incubation accuracy of the first reaction disc and the incubation accuracy of the second reaction disc is less than or equal to a third preset value; and the deviation of the light measurement accuracy of the first light receiving component and the light measurement accuracy of the second light receiving component is less than or equal to a fourth preset value. In this implementation, the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 can work in parallel, the first reaction disc and the second reaction disc can work in parallel, and the first light receiving component and the second light receiving component can work in parallel.

[0150] As an implementation, at least one of the following devices used in the first detection process and the second detection process is two devices that can work independently at least in part and are associated with correction parameters: the magnetic separation device 500 and the substrate dispensing device 101, that is, the first detection process and the second detection process can also not share the magnetic separation system and / or the substrate dispensing system.

[0151] As an implementation, for inconsistent components in the magnetic separation system and the substrate dispensing system, a correction parameter correction method (for example, a method similar to the partial component correction parameter identification code) can be used to make the performance of the shared parts of the magnetic separation system and the substrate dispensing system consistent.

[0152] In addition to the above differences, other parts of the sample analyzer 10 and the dispensing component provided by the present embodiment can refer to Embodiment One, which will not be described in detail here.

[0153] Embodiment Three:

[0154] Reference Figure 1 , Figure 2 andFigure 6 As shown, the sample analyzer 10 provided by the embodiment is mainly different from the sample analyzer of the first embodiment in that the multi-needle system is used for dispensing target liquid, specifically embodied in that in the first embodiment, the multi-needle system is used for dispensing sample; while in the embodiment, the multi-needle system is used for dispensing reagent.

[0155] Specifically, the sample analyzer 10 provided by the embodiment includes a sample dispensing device 100, a reagent dispensing device 200, an information acquisition component 105, a detection device 300, and a controller 400. The sample dispensing device 100 is used to perform a sample dispensing action of: sucking sample from a sample container, and dispensing at least part of the sucked sample into a reaction container. The reagent dispensing device 200 includes a first reagent dispensing assembly 210 and a second reagent dispensing assembly 220, and the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 are respectively used to perform a reagent dispensing action of: sucking reagent from a reagent container, and dispensing at least part of the sucked reagent into a reaction container; wherein the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 are two reagent dispensing assemblies whose at least part of components can independently perform the reagent dispensing action, and at least part of components of at least one of the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 is associated with a reagent addition correction parameter. The information acquisition component 105 is used to acquire the reagent addition correction parameter of the first reagent dispensing assembly 210 and / or the reagent addition correction parameter of the second reagent dispensing assembly 220. The detection device 300 is used to detect a to-be-tested liquid made of at least sample dispensed by the sample dispensing device 100 and reagent dispensed by the reagent dispensing device 200. The controller 400 is configured to: acquire the reagent addition correction parameter of the first reagent dispensing assembly 210 and / or the reagent addition correction parameter of the second reagent dispensing assembly 220 according to the information fed back by the information acquisition component 105; and correct the reagent dispensing amount of the first reagent dispensing assembly 210 in performing the reagent dispensing action and / or the reagent dispensing amount of the second reagent dispensing assembly 220 in performing the reagent dispensing action according to the reagent addition correction parameter of the first reagent dispensing assembly 210 and / or the reagent addition correction parameter of the second reagent dispensing assembly 220. In the embodiment, the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 can be used to perform reagent dispensing actions of the same detection item, and when batch detection of a certain detection item is needed, the first reagent dispensing assembly 210 can be controlled to perform reagent dispensing actions of a part of detection items, and the second reagent dispensing assembly 220 can be controlled to perform reagent dispensing actions of another part of detection items, so that the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 can be fully utilized to achieve the purpose of improving the detection efficiency of the sample analyzer 10. In addition, since the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 are associated with the reagent addition correction parameter in advance, the calibration process can be exempted from being performed on the machine, and the replaceability and the replacement simplicity of the multi-reagent needle system are greatly increased.

[0156] As an embodiment, at least part of the components of at least one of the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 is configured with an identification code, and the identification code is associated with the reagent addition correction parameter of the component; the information acquisition component 105 acquires the reagent addition correction parameter of the first reagent dispensing assembly 210 and / or the reagent addition correction parameter of the second reagent dispensing assembly 220 by identifying the identification code. In this embodiment, the reagent addition correction parameter is identified by a code, which greatly simplifies the complexity of manual operation. When the reagent dispensing assembly and the dispensing component are replaced, the reagent addition correction parameter can be directly configured by scanning the code.

[0157] As an embodiment, the first reagent dispensing assembly 210 includes a first reagent needle, and the second reagent dispensing assembly 220 includes a second reagent needle, and the first reagent needle and the second reagent needle are two reagent needles capable of independently performing reagent dispensing actions. The first reagent needle and the second reagent needle are both configured with an identification code, and the identification code is associated with the reagent addition correction parameter of the reagent needle.

[0158] As an embodiment, the first reagent dispensing assembly 210 further includes a third suction power component for providing driving force for the first reagent needle to perform suction action; the second reagent dispensing assembly 220 further includes a fourth suction power component for providing driving force for the second reagent needle to perform suction action, the first reagent needle and the second reagent needle are two reagent needles capable of independently performing reagent dispensing actions, and the third suction power component and the fourth suction power component are two suction power components capable of independently performing reagent dispensing actions. The third suction power component and the fourth suction power component are both configured with an identification code, and the identification code is associated with the reagent addition correction parameter of the suction power component.

[0159] As an embodiment, the controller 400 is configured to control the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 to respectively perform reagent dispensing actions of the same detection item of two samples.

[0160] As an implementation, the sample analyzer 10 further comprises a reaction device 900, a magnetic separation device 500, a substrate dispensing device 101, and a controller 400; the reagent dispensing device 200 performs a reagent dispensing action, which comprises: aspirating the magnetic bead reagent from the first reagent container and dispensing it into the reaction container, and aspirating the label reagent from the second reagent container and dispensing it into the reaction container; the reaction device 900 is used to carry the reaction container to perform an incubation action, which comprises: incubating a liquid containing at least the sample, the magnetic bead reagent, and the label reagent to prepare a first reaction liquid; the magnetic separation device 500 is used to perform a magnetic separation and washing operation on the first reaction liquid to prepare a second reaction liquid; the substrate dispensing device 101 is used to perform a substrate dispensing action, which comprises: aspirating the luminescent substrate reagent from the substrate reagent container, and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid to prepare a fourth reaction liquid with the luminescent substrate reagent; the detection device 300 is used to perform a detection action, which comprises: detecting the luminescent intensity of the fourth reaction liquid; and the controller 400 is configured to: control the same sample dispensing device 100 to perform a sample dispensing action of the same detection item of two samples, respectively, control the first reagent dispensing assembly 210 and the second reagent dispensing assembly 220 to perform a reagent dispensing action of the same detection item of the two samples, respectively, control the same reaction device 900 to perform an incubation action of the same detection item of the two samples, respectively, control the same magnetic separation device 500 to perform a magnetic separation and washing operation of the same detection item of the two samples, respectively, control the same substrate dispensing device 101 to perform a substrate dispensing action of the same detection item of the two samples, respectively, and control the same detection device 300 to perform a detection action of the same detection item of the two samples, respectively.

[0161] As an implementation, the first reagent dispensing assembly 210 further comprises a third washing driving component, which is used to drive the washing liquid from the second washing liquid supply device to flush the first reagent needle; the second reagent dispensing assembly 220 further comprises a fourth washing driving component, which is used to drive the washing liquid from the second washing liquid supply device to flush the second reagent needle; and the sample analyzer 10 further comprises a controller 400, which is configured to: when the third suction and injection power component is controlled to drive the first reagent needle to perform a reagent dispensing action, the fourth washing driving component is controlled to drive the washing liquid to flush the second reagent needle; and / or when the fourth suction and injection power component is controlled to drive the second reagent needle to perform a reagent dispensing action, the fourth washing driving component is controlled to drive the washing liquid to flush the first reagent needle.

[0162] The dispensing component provided by the embodiment is used to dispense reagents, and the dispensing component is configured with an identification code, the identification code is associated with a pipetting correction parameter (i.e., a reagent dispensing correction parameter) of the dispensing component, and the pipetting correction parameter is used to correct the liquid dispensing amount (i.e., the reagent dispensing amount) of the dispensing component.

[0163] As an embodiment, the dispensing component is a reagent needle for dispensing reagent, or a reagent suction power component for driving the reagent needle to perform a suction action.

[0164] As an embodiment, the identification code is formed on a label paper, and the label paper is attached to the dispensing component.

[0165] In addition to the above, other parts of the sample analyzer 10 and the dispensing component provided by the present embodiment can refer to Embodiment One and Embodiment Two, which will not be described in detail here.

[0166] Embodiment Four:

[0167] The sample analyzer 10 provided by the present embodiment is mainly different from Embodiment One in that the target liquid distributed by the multi-needle system is different, which is embodied in that in Embodiment One, the multi-needle system is used to distribute samples; while in the present embodiment, the multi-needle system is used to distribute samples and reagents.

[0168] Specifically, the sample analyzer 10 provided by the embodiment includes a pipetting device, an information acquisition component 105, a detection device 300, and a controller 400. The pipetting device is configured to perform liquid dispensing actions of: sucking a sample from a sample container and dispensing at least part of the sucked sample into a reaction container; and sucking a reagent from a reagent container and dispensing at least part of the sucked reagent into the reaction container. The pipetting device includes a first pipetting assembly and a second pipetting assembly, the first pipetting assembly and the second pipetting assembly are two pipetting assemblies of which at least part of components can independently perform liquid dispensing actions, and at least part of components of the first pipetting assembly and / or the second pipetting assembly are associated with pipetting correction parameters. The information acquisition component 105 is configured to acquire the pipetting correction parameters of the first pipetting assembly and / or the pipetting correction parameters of the second pipetting assembly. The detection device 300 is configured to detect a to-be-detected liquid. The controller 400 is configured to: acquire the pipetting correction parameters of the first pipetting assembly and / or the pipetting correction parameters of the second pipetting assembly according to information fed back by the information acquisition component 105; and correct the liquid dispensing amount of the first pipetting assembly in performing the liquid dispensing action and / or the liquid dispensing amount of the second pipetting assembly in performing the liquid dispensing action according to the pipetting correction parameters of the first pipetting assembly and / or the pipetting correction parameters of the second pipetting assembly. In the embodiment, the first pipetting assembly is configured to dispense both the sample and the reagent, and the second pipetting assembly is also configured to dispense both the sample and the reagent. The first pipetting assembly and the second pipetting assembly can be configured to perform sample dispensing actions and reagent dispensing actions of the same detection item. When batch detection of a certain detection item is required, the first pipetting assembly can be controlled to perform sample dispensing actions and reagent dispensing actions of a part of the detection items, and the second pipetting assembly can be controlled to perform sample dispensing actions and reagent dispensing actions of another part of the detection items. Therefore, the first pipetting assembly and the second pipetting assembly can be fully utilized to improve the detection efficiency of the sample analyzer 10. In addition, since the first pipetting assembly and the second pipetting assembly are associated with the pipetting correction parameters in advance, the calibration process can be omitted, and the replaceability and the replaceability of the multi-needle pipetting system are greatly improved.

[0169] As an implementation manner, at least part of components of at least one of the first pipetting assembly and the second pipetting assembly are configured with an identification code, and the identification code is associated with the pipetting correction parameters of the components. The information acquisition component 105 acquires the pipetting correction parameters of the first pipetting assembly and / or the pipetting correction parameters of the second pipetting assembly by identifying the identification code. In the embodiment, the pipetting correction parameters are identified by codes, which greatly simplifies the complexity of manual operation. When the pipetting assembly and the dispensing component are replaced, the pipetting correction parameters can be directly configured by scanning the code.

[0170] As an implementation, the first pipetting assembly includes a first pipetting needle, and the second pipetting assembly includes a second pipetting needle. The first pipetting needle and the second pipetting needle are two pipetting needles capable of independently performing sample dispensing actions and reagent dispensing actions. The first pipetting needle and the second pipetting needle are both configured with an identification code, and the identification code is associated with the reagent addition correction parameter of the reagent needle. The first pipetting needle is used for dispensing samples and reagents, and the second pipetting needle is also used for dispensing samples and reagents. The first pipetting needle and the second pipetting needle can be used to perform sample dispensing actions and reagent dispensing actions of the same detection item. When batch detection of a certain detection item is required, the first pipetting needle can be controlled to perform sample dispensing actions and reagent dispensing actions of a part of detection items, and the second pipetting needle can be controlled to perform sample dispensing actions and reagent dispensing actions of another part of detection items. Thus, the first pipetting needle and the second pipetting needle can be fully utilized to improve the detection efficiency of the sample analyzer 10.

[0171] As an implementation, the first pipetting assembly further includes a fifth pipetting power component for providing driving force for the first pipetting needle to perform pipetting actions, and the second pipetting assembly further includes a sixth pipetting power component for providing driving force for the second pipetting needle to perform pipetting actions. The fifth pipetting power component and the sixth pipetting power component are two pipetting power components capable of independently performing sample dispensing actions and reagent dispensing actions. The fifth pipetting power component and the sixth pipetting power component are both configured with an identification code, and the identification code is associated with the pipetting correction parameter of the pipetting power component.

[0172] As an implementation, the controller 400 is configured to control the first pipetting assembly and the second pipetting assembly to respectively perform sample dispensing actions and reagent dispensing actions of the same detection item of two samples, that is, the first pipetting assembly performs sample dispensing actions and reagent dispensing actions of the same detection item of one sample, and the second pipetting assembly performs sample dispensing actions and reagent dispensing actions of the same detection item of another sample.

[0173] As an implementation, the sample analyzer 10 further comprises a reaction device 900, a magnetic separation device 500, a substrate dispensing device 101, and a controller 400; the pipetting device aspirates reagents from reagent containers and dispenses at least part of the aspirated reagents into the reaction container, including: aspirating magnetic bead reagents from a first reagent container and dispensing into the reaction container, aspirating marker reagents from a second reagent container and dispensing into the reaction container; the reaction device 900 is used to carry the reaction container to perform the following incubation actions: incubating a liquid containing at least the sample, the magnetic bead reagent, and the marker reagent to produce a first reaction liquid; the magnetic separation device 500 is used to perform a magnetic separation and washing operation on the first reaction liquid to produce a second reaction liquid; the substrate dispensing device 101 is used to perform the following substrate dispensing action: aspirating a luminescent substrate reagent from a substrate reagent container and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid to produce a fourth reaction liquid with the luminescent substrate reagent; the detection device 300 is used to perform the following detection action: detecting the luminescent intensity of the test liquid; the controller 400 is configured to: control the first pipetting assembly and the second pipetting assembly to respectively perform liquid dispensing actions of the same detection item of the two samples, control the same reaction device 900 to respectively perform incubation actions of the same detection item of the two samples, control the same magnetic separation device 500 to respectively perform magnetic separation and washing operations of the same detection item of the two samples, control the same substrate dispensing device 101 to respectively perform substrate dispensing actions of the same detection item of the two samples, and control the same detection device 300 to respectively perform detection actions of the same detection item of the two samples.

[0174] As an implementation, the first pipetting assembly further comprises a fifth cleaning driving component, the fifth cleaning driving component is used to at least drive the cleaning liquid from the third cleaning liquid supply device to flush the first pipetting needle; the second pipetting assembly further comprises a sixth cleaning driving component, the sixth cleaning driving component is used to at least drive the cleaning liquid from the third cleaning liquid supply device to flush the second pipetting needle; the sample analyzer 10 further comprises a controller 400, the controller 400 is configured to: when controlling the first pipetting power source to drive the first pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive the cleaning liquid to flush the second pipetting needle; and / or, when controlling the second pipetting power source to drive the second pipetting needle to perform the liquid dispensing action, control the sixth cleaning driving component to drive the cleaning liquid to flush the first pipetting needle.

[0175] The dispensing component provided by the embodiment is used to dispense samples and reagents, the dispensing component is configured with an identification code, the identification code is associated with pipetting correction parameters of the dispensing component, and the pipetting correction parameters are used to correct the liquid dispensing amount of the dispensing component.

[0176] As an embodiment, the dispensing component is a pipette needle for dispensing the sample and the reagent, or a pipetting power source for driving the pipette needle to perform a liquid dispensing action.

[0177] As an embodiment, the identification code is formed on a label paper, which is attached to the dispensing component.

[0178] In addition to the above, other parts of the sample analyzer 10 and the dispensing component provided by the present embodiment can refer to Embodiment One and Embodiment Two, which will not be described in detail here.

[0179] The above is only the preferred embodiment of the present application, and does not limit the patent scope of the present application. Any equivalent structural transformation made under the inventive concept of the present application, using the contents of the present application specification and drawings, or directly / indirectly applied to other related technical fields is included in the patent protection scope of the present application.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, comprising a first sample dispensing assembly and a second sample dispensing assembly, wherein the first sample dispensing assembly and the second sample dispensing assembly are respectively configured to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; wherein the first sample dispensing assembly and the second sample dispensing assembly are two dispensing assemblies, at least some of whose components can independently perform the sample dispensing action, and at least some of the components of at least one of the first sample dispensing assembly and the second sample dispensing assembly are associated with sample loading calibration parameters; A reagent dispensing device, the reagent dispensing device is used to perform the following reagent dispensing action: sucking the reagent from the reagent container and dispensing at least part of the sucked reagent into the reaction container; an information acquisition component, configured to acquire a sample loading calibration parameter of the first sample dispensing component and / or a sample loading calibration parameter of the second sample dispensing component; a detection device for detecting a test solution made of at least the sample dispensed by the sample dispensing device and the reagent dispensed by the reagent dispensing device; A controller configured to: obtain a sample loading correction parameter of the first sample dispensing component and / or a sample loading correction parameter of the second sample dispensing component based on information fed back by the information acquisition component; and calibrate a sample dispensing amount of the first sample dispensing component in executing the sample dispensing action and / or a sample dispensing amount of the second sample dispensing component in executing the sample dispensing action based on the sample loading correction parameter of the first sample dispensing component and / or the sample loading correction parameter of the second sample dispensing component.

2. The sample analyzer according to claim 1, wherein: At least some components of at least one of the first sample dispensing component and the second sample dispensing component are configured with an identification code, wherein the identification code is associated with a sample loading calibration parameter of the component; The information acquisition component obtains the sample loading calibration parameters of the first sample dispensing component and / or the sample loading calibration parameters of the second sample dispensing component by identifying the identification code.

3. The sample analyzer according to claim 2, wherein: At least part of at least one of the first sample dispensing component and the second sample dispensing component is pasted with a label paper, and the identification code is provided on the label paper.

4. The sample analyzer according to claim 1, wherein: The first sample dispensing component includes a first suction component, and the second sample dispensing component includes a second suction component. The first suction component and the second suction component are two suction components that can perform the sample dispensing action independently of each other. At least one of the first suction component and the second suction component is associated with a sample addition correction parameter.

5. The sample analyzer according to claim 4, wherein: The first aspirating component is configured with a first identification code, the first identification code is associated with a sample addition correction parameter of the first aspirating component, the information acquisition component is used to identify the first identification code, and the controller is further configured to: obtain the sample addition correction parameter of the first aspirating component based on information fed back by the information acquisition component when identifying the first identification code; correct the sample distribution amount of the first sample dispensing component when performing the sample distribution action according to at least the sample addition correction parameter of the first aspirating component, so that the deviation between the sample distribution accuracy of the first sample dispensing component and the sample distribution accuracy of the second sample dispensing component is less than or equal to a first preset value; and / or, The second aspiration component is configured with a second identification code, and the second identification code is associated with the sample addition correction parameters of the second aspiration component. The information acquisition component is used to identify the second identification code. The controller is also configured to: obtain the sample addition correction parameters of the second aspiration component based on the information feedback by the information acquisition component when identifying the second identification code, and at least correct the sample distribution amount of the second sample dispensing component when performing the sample distribution action based on the sample addition correction parameters of the second aspiration component, so that the deviation between the sample distribution accuracy of the first sample dispensing component and the sample distribution accuracy of the second sample dispensing component is less than or equal to a first preset value.

6. The sample analyzer according to claim 4, wherein: The first aspiration component is associated with the sample addition correction parameters of the first aspiration component, and the second aspiration component is associated with the sample addition correction parameters of the second aspiration component. The sample addition correction parameters of the first aspiration component and the sample addition correction parameters of the second aspiration component use the same target value as the sample addition correction reference.

7. The sample analyzer according to claim 4, wherein: The first aspirating component is configured with a first identification code, and the first identification code is associated with a sample loading calibration parameter of the first aspirating component. The controller is further configured to: before controlling the first aspirating component to perform the first sample dispensing action on the sample analyzer, obtain the sample loading calibration parameter of the first aspirating component based on information fed back by the information acquisition component when identifying the first identification code; and / or, The second aspiration component is configured with a second identification code, and the second identification code is associated with the sample addition correction parameters of the second aspiration component. The controller is also configured to: before controlling the second aspiration component to perform the first sample distribution action on the sample analyzer, obtain the sample addition correction parameters of the second aspiration component based on the information feedback of the second identification code identified by the information acquisition component.

8. The sample analyzer according to claim 4, wherein: The first aspirating component is configured with a first identification code, and the first identification code is associated with a sample addition calibration parameter of the first aspirating component. The controller is further configured to: when the first aspirating component is replaced or when the first aspirating component is first assembled on the sample analyzer, obtain the sample addition calibration parameter of the first aspirating component based on information fed back by the information acquisition component when the first identification code is identified; and / or, The second suction and injection component is configured with a second identification code, and the second identification code is associated with the sample addition correction parameters of the second suction and injection component. The controller is also configured to: when the second suction and injection component is replaced or when the second suction and injection component is first assembled on the sample analyzer, obtain the sample addition correction parameters of the second suction and injection component based on the information feedback by the information acquisition component identifying the second identification code.

9. The sample analyzer according to any one of claims 4 to 8, wherein: The first aspiration component is a first sample needle, and the second aspiration component is a second sample needle; or The first suction component is a first suction power component, which is used to provide driving force for the first sample needle to perform the suction action. The second suction component is a second suction power component, which is used to provide driving force for the second sample needle to perform the suction action.

10. The sample analyzer according to any one of claims 1 to 9, wherein: The controller is configured to execute the following project calibration process for a first test project: controlling the first sample dispensing assembly to draw a project calibrator from a calibrator container and dispense it into a reaction container, controlling the reagent dispensing device to draw a reagent from a reagent container and dispense it into the reaction container; controlling the detection device to detect a calibration solution in the reaction container made of at least the project calibrator and the reagent, and obtaining first calibration data corresponding to the first test project based on detection information fed back by the detection device; The controller is also configured to execute the following second detection process for the first detection item: control the second sample dispensing component to perform the sample dispensing action, control the reagent dispensing device to perform the reagent dispensing action, control the sample detection device to detect the test liquid made of at least the sample dispensed by the second sample dispensing component and the reagent dispensed by the reagent dispensing device, obtain second detection data based on the detection information fed back by the detection device, and obtain a second detection result based on the second detection data and the first calibration data corresponding to the first detection item.

11. The sample analyzer according to any one of claims 1 to 9, wherein: The deviation between the sample dispensing accuracy of the first sample dispensing component and the sample dispensing accuracy of the second sample dispensing component is less than or equal to a first preset value, and the first preset value is greater than or equal to zero and less than or equal to 5%; and / or, The controller is further configured to control the first sample dispensing component and the second sample dispensing component to respectively perform the sample dispensing action of the same detection item of two samples.

12. The sample analyzer according to any one of claims 1 to 9, wherein: The sample analyzer further comprises a reaction device, which is used to carry the reaction container and perform the following incubation actions: incubating a liquid containing at least a sample and a reagent; The controller is also configured to: control the first sample dispensing component and the second sample dispensing component to respectively perform the sample dispensing action of the same detection item of the two samples, control the same reagent dispensing device to respectively perform the reagent dispensing action of the same detection item of the two samples; control the same reaction device to respectively perform the incubation action of the same detection item of the two samples; and control the same detection device to respectively detect the test liquid made of the two samples and the reagent.

13. The sample analyzer according to claim 12, wherein: The reagent dispensing device performs the reagent dispensing action including: drawing a magnetic bead reagent from a first reagent container and dispensing it into a reaction container, and drawing a marker reagent from a second reagent container and dispensing it into a reaction container; The reaction device is used to carry the reaction container to perform the following incubation action: incubating at least the sample, the magnetic bead reagent, and the marker reagent to produce a first reaction solution; The sample analyzer further includes a magnetic separation device and a substrate dispensing device, wherein the magnetic separation device is used to perform a magnetic separation and cleaning operation on the first reaction liquid to produce a second reaction liquid; The substrate dispensing device is used to perform the following substrate dispensing action: aspirating the luminescent substrate reagent from the substrate reagent container, and dispensing at least part of the aspirated luminescent substrate reagent into the reaction container loaded with the second reaction liquid, so that the second reaction liquid and the luminescent substrate reagent are combined to form the test liquid; The detection device is used to detect the luminescence intensity of the liquid to be tested; The controller is further configured to: control the same magnetic separation device to respectively perform the magnetic separation and washing operations for the same detection item of two samples; and control the same substrate dispensing device to respectively perform the substrate dispensing operations for the same detection item of the two samples.

14. The sample analyzer according to any one of claims 1 to 9, wherein: The reagent dispensing device comprises at least two reagent dispensing components which are at least partially capable of performing the reagent dispensing action independently of each other and are associated with calibration parameters; and / or, The sample analyzer further comprises a reaction device, the reaction device being used to carry a reaction container and perform the following incubation action: incubating a liquid containing at least a sample and a reagent; the reaction device comprising at least two incubation components at least partially capable of performing the incubation action independently of each other and associated with calibration parameters; and / or, The detection device comprises at least two detection components which are at least partially capable of detecting the liquid to be tested independently of each other and are associated with calibration parameters.

15. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to perform the following sample dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; A reagent dispensing device, comprising a first reagent dispensing assembly and a second reagent dispensing assembly, wherein the first reagent dispensing assembly and the second reagent dispensing assembly are respectively configured to perform the following reagent dispensing actions: aspirating a reagent from a reagent container and dispensing at least a portion of the aspirated reagent into a reaction container; wherein the first reagent dispensing assembly and the second reagent dispensing assembly are two dispensing assemblies, at least some of whose components can independently perform the reagent dispensing action, and at least some of the components of at least one of the first reagent dispensing assembly and the second reagent dispensing assembly are associated with reagent addition calibration parameters; an information acquisition component, the information acquisition component being used to acquire a reagent addition calibration parameter of the first reagent dispensing component and / or a reagent addition calibration parameter of the second reagent dispensing component; a detection device for detecting a test solution made of at least the sample dispensed by the sample dispensing device and the reagent dispensed by the reagent dispensing device; A controller, wherein the controller is configured to: obtain the reagent addition correction parameters of the first reagent dispensing component and / or the reagent addition correction parameters of the second reagent dispensing component based on the information fed back by the information acquisition component; and calibrate the reagent dispensing amount of the first reagent dispensing component in executing the reagent dispensing action and / or the reagent dispensing amount of the second reagent dispensing component in executing the reagent dispensing action based on the reagent addition correction parameters of the first reagent dispensing component and / or the reagent addition correction parameters of the second reagent dispensing component.

16. The sample analyzer according to claim 15, wherein: At least some components of at least one of the first reagent dispensing assembly and the second reagent dispensing assembly are configured with an identification code, wherein the identification code is associated with a reagent addition calibration parameter of the component; The information acquisition component acquires the reagent addition calibration parameters of the first reagent dispensing component and / or the reagent addition calibration parameters of the second reagent dispensing component by identifying the identification code.

17. A sample analyzer, characterized in that: include: A pipetting device, the pipetting device being configured to perform the following liquid dispensing actions: aspirating a sample from a sample container and dispensing at least a portion of the aspirated sample into a reaction container; and aspirating a reagent from a reagent container and dispensing at least a portion of the aspirated reagent into the reaction container; wherein the pipetting device comprises a first pipetting assembly and a second pipetting assembly, the first pipetting assembly and the second pipetting assembly being two pipetting assemblies at least partially capable of independently performing the liquid dispensing actions, and at least partially associated with the first pipetting assembly and / or the second pipetting assembly are pipetting calibration parameters; an information acquisition component, configured to acquire a pipetting calibration parameter of the first pipetting component and / or a pipetting calibration parameter of the second pipetting component; A detection device, the detection device is used to detect the liquid to be tested; A controller configured to: obtain the pipetting correction parameters of the first pipetting component and / or the pipetting correction parameters of the second pipetting component based on the information fed back by the information acquisition component; and correct the liquid distribution volume of the first pipetting component in performing the liquid distribution action and / or the liquid distribution volume of the second pipetting component in performing the liquid distribution action based on the pipetting correction parameters of the first pipetting component and / or the pipetting correction parameters of the second pipetting component.

18. The sample analyzer according to claim 17, wherein: At least some components of at least one of the first pipetting assembly and the second pipetting assembly are configured with an identification code, wherein the identification code is associated with a pipetting calibration parameter of the component; The information acquisition component acquires the pipetting calibration parameters of the first pipetting component and / or the pipetting calibration parameters of the second pipetting component by identifying the identification code.

19. A dispensing component for dispensing a sample, a reagent, or both a sample and a reagent, characterized in that: The dispensing component is configured with an identification code, and the identification code is associated with a pipetting correction parameter of the dispensing component, and the pipetting correction parameter is used to calibrate the liquid dispensing amount of the dispensing component.

20. The dispensing component according to claim 19, wherein: The dispensing component is: a sample needle for dispensing a sample, or a reagent needle for dispensing a reagent, or a pipetting needle for dispensing a sample and a reagent, or a sample aspirating power component for driving the sample needle to perform an aspirating action, or a reagent aspirating power component for driving the reagent needle to perform an aspirating action, or a pipetting power source for driving the pipetting needle to perform a liquid dispensing action; and / or, The identification code is formed on a label paper, and the label paper is pasted on the dispensing component.

Images