A surfactant composition and its use

Abstract

The application discloses a surfactant composition and application thereof, and belongs to the technical field of cosmetics.The surfactant composition provided by the application comprises sodium lauroyl glutamate, decyl glucoside, Tween-28, a betaine surfactant, a glycolipid and mucunna pruriens polysaccharide.The surfactant composition provided by the application can greatly reduce the dissolution of intercellular lipids and natural moisturizing factors and the damage to proteins on the basis of good surface activity, does not affect the skin barrier function, has a regulating effect on the skin microecosystem, balances the skin microecosystem, does not reduce the number of beneficial bacteria in the skin microecosystem, but can help reduce the number of harmful bacteria in the skin microecosystem, thereby effectively improving the skin barrier function and keeping the skin healthy.When applied to subsequent washing and protecting products, the washing and protecting products obtained are excellent in safety.

Description

A surfactant composition and its application Technical Field

[0001] This invention belongs to the field of cosmetic technology, and particularly relates to a surfactant composition and its application. Background Technology

[0002] Infants' skin barrier function is not fully developed and is easily affected by external stimuli and damage. Surfactants, a common ingredient in cleansing products, can damage the skin barrier, especially for patients with atopic dermatitis (AD), where improper use of surfactants may worsen skin problems.

[0003] Existing technologies reduce product irritation by compounding surfactants, adding polymers, and other soothing and anti-irritant ingredients. However, there is still a risk of damaging intercellular lipids, natural moisturizing factors, and proteins in the skin, especially affecting the skin barrier function of infants and children with Alzheimer's disease (AD). Furthermore, there is limited research on the impact of existing baby bath products on the skin's microecology; some products may disrupt the microecological balance on the skin surface, affecting skin health. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a surfactant composition and its application that, based on good surface activity, greatly reduces the dissolution of intercellular lipids and natural moisturizing factors in the skin and the damage to proteins, without affecting the skin barrier function; and has a regulatory effect on the skin microecology, balancing the skin microecology, without reducing the number of beneficial bacteria in the skin microecology, but can help reduce the number of harmful bacteria in the skin microecology, thereby improving the skin barrier function and maintaining skin health. Furthermore, when applied to washing and care products, it results in washing and care products with excellent safety.

[0005] To achieve the above objectives, in a first aspect of the present invention, the present invention provides a surfactant composition comprising sodium lauroyl glutamate, decyl glucoside, Tween-28, betaine-type surfactant, glycolipid, and soybean seed polysaccharide.

[0006] This invention has revealed that the composition provided by this invention, through the selection and compounding of the aforementioned six components, exhibits excellent interactions among the components. The resulting surfactant composition, while possessing good surface activity, significantly reduces the dissolution of intercellular lipids and natural moisturizing factors in the skin, as well as the damage to proteins. It does not affect the skin barrier function and has a regulatory effect on the skin microecology, balancing it and not reducing the number of beneficial bacteria. Instead, it helps reduce the number of harmful bacteria in the skin microecology, thereby enhancing the skin barrier function and maintaining skin health. Furthermore, when the prepared surfactant composition is subsequently applied to personal care products, the resulting products demonstrate excellent overall performance and good safety.

[0007] Specifically, sodium lauroyl glutamate (SLA) is an amino acid-based surfactant with excellent cleaning power, effectively removing dirt. This invention also found that SLA can effectively reduce the dissolution of intercellular lipids in skin cells. Decyl glucoside is a nonionic surfactant with a short carbon chain, which can synergistically enhance the cleaning power of the surfactant composition with SLA. It can also work with other components to reduce the irritation of the surfactant composition. Furthermore, decyl glucoside can reduce the risk of dissolution of intercellular lipids and damage to skin proteins, effectively stabilizing the skin barrier. Tween-28 is also a nonionic surfactant that can synergize with SLA and decyl glucoside to achieve excellent overall surface activity of the surfactant composition. It can also work with other components to reduce the irritation of the surfactant composition, improve its mildness, and thus reduce the risk of damage to the skin barrier. Betaine-type surfactants are amphoteric surfactants that can synergistically improve the foaming performance and consistency of the composition, reducing the amount of traditional thickeners needed when applied to washing and care products, and improving the product's mildness. Glycolipids are a type of biological surfactant with excellent microecological friendly properties. They can help maintain the skin's microecological balance, reduce the damage of surfactant compositions to skin proteins, and help improve the skin barrier function. In the system of this invention, soybean seed polysaccharide plays a good role as a polymeric network framework, effectively reducing the contact between surfactants and the skin, thereby reducing surfactant irritation, reducing the dissolution of intercellular lipids and natural moisturizing factors in the stratum corneum, and minimizing damage to the skin barrier. Simultaneously, its excellent moisturizing effect can improve skin barrier function.

[0008] As a preferred embodiment of the surfactant composition of the present invention, the surfactant composition comprises the following components in parts by weight: 0.5-8 parts sodium lauroyl glutamate, 1-10 parts decyl glucoside, 0.5-8 parts Tween-28, 1-8 parts betaine-type surfactant, 0.05-3 parts glycolipid, and 0.02-0.5 parts soybean seed polysaccharide.

[0009] As a preferred embodiment of the surfactant composition of the present invention, the surfactant composition comprises the following components in parts by weight: 3-6 parts sodium lauroyl glutamate, 4-8 parts decyl glucoside, 2-4 parts Tween-28, 3-6 parts betaine-type surfactant, 0.5-2 parts glycolipid, and 0.2-0.4 parts soybean seed polysaccharide.

[0010] This invention has found that the amount of each component added to a surfactant composition affects the interaction between the components, thereby affecting the surface activity, skin barrier enhancement, and skin microecological regulation of the resulting product after the surfactant composition is applied to a washing and care product. It also affects the irritation of the subsequently prepared washing and care product. When the mass fraction of the components in the surfactant composition is further selected within the above range, the overall performance of the obtained product is better.

[0011] As a preferred embodiment of the surfactant composition of the present invention, the sum of the mass percentages of the sodium lauroyl glutamate and glycolipid is ≥16% based on the total mass of the surfactant composition.

[0012] Preferably, the sum of the mass percentages of sodium lauroyl glutamate and glycolipid is 16-45% based on the total mass of the surfactant composition.

[0013] For example, the mass percentage of sodium lauroyl glutamate and glycolipid, based on the total mass of the surfactant composition, can be any point value or any two-point range between 16% and 45%, such as 16%, 17%, 18%, 20%, 22%, 25%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, 40%, 42%, 44%, 45%, etc.

[0014] More preferably, the sum of the mass percentages of the sodium lauroyl glutamate and glycolipid is 23-37% based on the total mass of the surfactant composition.

[0015] This invention has found that the sum of the mass percentages of sodium lauroyl glutamate and glycolipids in a surfactant composition can affect the cleaning ability and mildness of the surfactant composition to a certain extent. When the sum of the mass percentages of sodium lauroyl glutamate and glycolipids is further selected to be 16-45%, especially 23-37%, the resulting surfactant composition not only has excellent surface activity and high cleaning ability, but also has extremely low dissolution effect on intercellular lipids and natural moisturizing factors in the skin. At the same time, it can also effectively enhance the skin barrier function and keep the skin moisturized for a longer period of time after use.

[0016] In a preferred embodiment of the surfactant composition of the present invention, the mass ratio of the sum of the masses of decyl glucoside and Tween-28 to the mass ratio of soybean seed polysaccharide is ≤185.

[0017] Preferably, the mass ratio of the sum of the masses of decyl glucoside and Tween-28 to the mass ratio of soybean seed polysaccharide is 21-180.

[0018] For example, the mass ratio of the sum of the masses of decyl glucoside and Tween-28 to soybean seed polysaccharide can be any point value or any two points between 21 and 180, such as 21, 25, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, etc.

[0019] More preferably, the mass ratio of the sum of the masses of decyl glucoside and Tween-28 to the mass ratio of soybean seed polysaccharide is 25-40.

[0020] This invention has found that the mass ratio of the sum of decyl glucoside and Tween-28 to soybean seed polysaccharide not only affects the surface activity of the surfactant composition, but also its effect on the skin microecology and its protective ability against the skin barrier. When the mass ratio of the sum of decyl glucoside and Tween-28 to soybean seed polysaccharide is further selected to be 21-180, especially 25-40, the overall performance of the obtained surfactant composition is better.

[0021] As a preferred embodiment of the surfactant composition of the present invention, the betaine-type surfactant includes at least one of cocoyl hydroxysulfonate betaine, cocamidopropyl hydroxysulfonate betaine, cocamidopropyl betaine, lauryl hydroxysulfonate betaine, lauridopropyl hydroxysulfonate betaine, and lauridopropyl betaine.

[0022] In a preferred embodiment of the surfactant composition of the present invention, the betaine-type surfactant is cocamidopropyl betaine.

[0023] As a preferred embodiment of the surfactant composition of the present invention, the glycolipid includes at least one of sophorolipid, mannoerythritol lipolipid, and trehalolipid.

[0024] In a preferred embodiment of the surfactant composition of the present invention, the glycolipid is a lactone-type sophorolipid.

[0025] The present invention has found that different glycolipids have different effects and different interactions with other components in the surfactant composition. When glycolipids of the above types are selected, especially lactone-type sophorolipids, the overall performance of the obtained surfactant composition is better.

[0026] In a second aspect, the present invention provides the use of the surfactant composition in the preparation of personal care products.

[0027] The surfactant composition provided by this invention has good surface activity and excellent foaming performance; at the same time, it also has excellent mildness, which is reflected in greatly reducing the dissolution of intercellular lipids and natural moisturizing factors in the skin, greatly reducing the damage to skin proteins, and enhancing the skin barrier function; in addition, it also has the effect of maintaining the skin microecological balance and improving the skin health status; thus, it can be widely used in washing and care products, especially suitable for infant washing and care products and washing and care products for AD patients; and the resulting washing and care products have excellent safety.

[0028] As a preferred embodiment of the application described in this invention, the personal care product includes any one of shower gel, 2-in-1 shampoo and body wash, shampoo, and facial cleanser.

[0029] In a third aspect, the present invention provides a shower gel comprising the surfactant composition described herein.

[0030] As a preferred embodiment of the shower gel of the present invention, the shower gel comprises the following components by weight percentage: 25-50% of the surfactant composition of the present invention, 0.5-2% of the emulsifier, 0.3-1.5% of the preservative, 0.05-2% of the thickener, 0.05-0.6% of the pH adjuster, 0.01-0.05% of the chelating agent, and the balance being water.

[0031] This invention has found that by adding a surfactant composition within the above-mentioned mass percentage range to a shower gel, it is possible to achieve both good cleansing and skin care capabilities; specifically, it can maintain the skin barrier function and provide long-lasting moisturization; furthermore, the resulting shower gel exhibits excellent safety.

[0032] Preferably, the fat-adhesive includes at least one of glyceryl oleate and PEG-7 glyceryl cocoate.

[0033] Preferably, the preservative includes at least one of phenoxyethanol and sodium benzoate.

[0034] Preferably, the thickener includes at least one of PEG-150 distearate, PEG-120 methyl glucoside, hydroxypropyl methylcellulose, sodium chloride, and carbomer.

[0035] Preferably, the pH adjuster includes at least one of citric acid and lactic acid.

[0036] Preferably, the chelating agent includes at least one of disodium EDTA and tetrasodium EDTA.

[0037] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0038] This invention utilizes a compound of sodium lauroyl glutamate, decyl glucoside, Tween-28, betaine-type surfactants, glycolipids, and soybean seed polysaccharides. These components exhibit excellent interactions, significantly reducing the dissolution of intercellular lipids and natural moisturizing factors, as well as protein damage, while maintaining good surface activity, without affecting the skin barrier function. Furthermore, it regulates and balances the skin microecology, preventing a decrease in beneficial bacteria and instead helping to reduce harmful bacteria, thereby improving skin health. When applied to subsequent hair care products, the resulting products demonstrate excellent safety and provide a superior user experience. Attached Figure Description

[0039] Figure 1 shows the results of the stimulus test in Example 1 in Effect Example 2;

[0040] Figure 2 shows the results of the stimulation test in Example 10 compared to the effect example 2. Detailed Implementation

[0041] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0042] Unless otherwise specified, the reagents, methods and equipment used in this invention are all conventional reagents, methods and equipment in the field; and unless otherwise specified, the raw materials used in parallel experiments are from the same batch.

[0043] Glycolipid 1: Lactone-type sophorolipid, brand name Ecolife SL-02, purchased from Shanghai Boku Biotechnology Co., Ltd.;

[0044] Glycolipid 2: Acidic sophorolipid, brand name Ecolife SL-03, purchased from Shanghai Boku Biotechnology Co., Ltd.;

[0045] Tamarind seed polysaccharide: brand name XILOGEL T, purchased from Givaudan International SA.

[0046] Examples 1-7 and Comparative Examples 1-7

[0047] The present invention provides a surfactant composition in the embodiments and comparative examples, wherein the components (parts by mass) of the surfactant composition are shown in Table 1; wherein W1 represents the sum of the mass percentages of sodium lauroyl glutamate and glycolipid based on the total mass of the surfactant composition, and W2 represents the mass ratio of the sum of the mass of decyl glucoside and Tween-28 to the mass of soybean seed polysaccharide.

[0048] Table 1

[0049]

[0050] The method for preparing the surfactant composition provided in Example 1 is as follows: the components are mixed evenly to obtain the surfactant composition.

[0051] The preparation methods of the surfactant compositions provided in Examples 2-7 and Comparative Examples 1-7 are consistent with those in Example 1; if the relevant components are not available, they can be omitted.

[0052] Example 8

[0053] This invention provides a surfactant composition, the only difference between the surfactant composition and that of Example 1 is that glycolipid 2 is used instead of glycolipid 1.

[0054] Example 9

[0055] This invention provides a surfactant composition, the only difference between the surfactant composition and Example 1 is that mannoerythritol ester is used instead of glycolipid 1.

[0056] Example 10

[0057] This invention provides a surfactant composition, the only difference between the surfactant composition and that of Example 1 is that lauryl hydroxysulfonate betaine is used instead of cocamidopropyl betaine.

[0058] Comparative Example 8

[0059] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being that disodium cocoyl glutamate is used instead of sodium lauroyl glutamate.

[0060] Comparative Example 9

[0061] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being lauryl glucoside instead of decyl glucoside.

[0062] Comparative Example 10

[0063] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being the use of Tween-20 instead of Tween-28.

[0064] Comparative Example 11

[0065] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being that sodium subtilisin lipopeptide is used instead of glycolipid 1.

[0066] Comparative Example 12

[0067] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being the use of β-glucan instead of soybean seed polysaccharide.

[0068] Comparative Example 13

[0069] The present invention provides a surfactant composition in a comparative example, the only difference between the surfactant composition and Example 1 being that sodium lauroamphoacetate is used instead of cocamidopropyl betaine.

[0070] Application Example 1-12, Comparison of Application Example 1-13 and Blank Application Example

[0071] The present invention provides a shower gel in application examples, comparative application examples, and blank application examples. The components (mass percentage) of the shower gel are shown in Table 2. In application examples 1-10, the surfactant compositions used are the surfactant compositions prepared in examples 1-10, for example, application example 1 uses the surfactant composition from example 1, application example 2 uses the surfactant composition from example 2, and so on. In comparative application examples 1-13, the surfactant compositions used are the surfactant compositions prepared in comparative examples 1-13. In application examples 11-12, the surfactant compositions used are the surfactant compositions prepared in example 1.

[0072] Table 2

[0073]

[0074] The method for preparing the shower gel provided in Example 1 includes the following steps:

[0075] (1) Add water and chelating agent to the main pot, heat to 80°C while stirring, until completely dissolved;

[0076] (2) Add sodium lauroyl glutamate, decyl glucoside, Tween-28, cocamidopropyl betaine, glycolipid 1 and thickener into the main pot in sequence and stir until uniform;

[0077] (3) Cool down to 40℃, add the remaining material, adjust the pH to 5.5, stir evenly, take a sample and send it for testing. Once it passes the test, the product can be discharged to obtain the shower gel.

[0078] The preparation methods of the shower gels provided in Application Examples 2-12, Comparative Application Examples 1-13, and Blank Application Examples are consistent with those in Application Example 1; if the relevant components are not available, they can be omitted.

[0079] Example 1

[0080] The effects of this invention are investigated by testing the dissolution of the shower gel prepared by the application examples, comparative application examples, and blank application examples on intercellular lipids and natural moisturizing factors (NMF) of the skin, its influence on the skin barrier, its role in maintaining the skin microecology, and its surface activity.

[0081] 1. Intercellular lipids and natural moisturizing factors are key indicators affecting the skin barrier function. Therefore, by testing the dissolution rate of shower gel on intercellular lipids and natural moisturizing factors, the effect of shower gel on the skin barrier can be reflected. Cholesterol is used as the representative component of intercellular lipids, and pyrrolidone carboxylic acid (PCA) is used as the representative component of natural moisturizing factors.

[0082] The specific testing includes the following steps: For sensitive skin (TEWL ≥ 20g / hm) 2 Three subjects per group underwent dissolution tests for cholesterol and PCA. Subjects 1-3 used the sample from Application Example 1 on the inner side of their left forearm and the control sample from Application Example 1 on their right side; subjects 4-6 used the sample from Application Example 2 on the inner side of their left forearm and the control sample from Application Example 2 on their right side; and so on. Subjects 37-39 used the blank application sample on the inner side of their left forearm and the control sample from Application Example 13 on their right side. The dissolution of cholesterol and PCA by the shower gel was determined using high-performance liquid chromatography combined with a shaking cup method.

[0083] The specific operation of the vibrating cup method is as follows: cholesterol and PCA are extracted using the vibrating cup method. A 3cm*3cm area on the inside of the subject's forearm is fixed. A cylinder (vibrating cup, inner diameter 2.5cm) is placed tightly against the fixed area. 10mL of shower gel sample is added to the cylinder and the sample is extracted by shaking for 10min to obtain the test solution.

[0084] The content of cholesterol and PCA dissolved in the test solution was quantitatively determined using a Waters 1525 high-performance liquid chromatograph with external standard method. The final dissolved amount was the average of the three values. Cholesterol dissolution test: Cholesterol standard (chromatographic grade, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) was prepared with methanol to a concentration of 5 mg / L, 25 mg / L, 50 mg / L, 100 mg / L, and 200 mg / L to plot a standard curve; methanol-isopropanol was used as the mobile phase, and the detection wavelength was 205 nm. PCA dissolution test: PCA standard (chromatographic grade, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) was prepared with PCA to a concentration of 50 mg / L, 75 mg / L, 100 mg / L, 125 mg / L, and 150 mg / L to plot a standard curve; acetonitrile-0.05 mol / L potassium dihydrogen phosphate was used as the mobile phase, and the detection wavelength was 205 nm.

[0085] The dissolution results of the corresponding shower gels for cholesterol and natural moisturizing factors are shown in Table 3.

[0086] 2. Surfactants in shower gels can bind to keratin in the stratum corneum, causing keratin denaturation and leading to skin irritation, dryness, and swelling of the stratum corneum. In an in vitro protein model, the zein test was used to simulate and evaluate the irritant effect of shower gels on keratin.

[0087] The specific testing includes the following steps: Prepare a 10% aqueous solution of the shower gel sample, add a certain amount of Zein until it no longer dissolves, stir at 330 rpm for 1 hour, let stand, and take 20 μL of the supernatant to dilute to 200 μL to obtain the test solution; dilute 20 mg / mL bovine serum albumin (BSA) with purified water to prepare concentrations of 1.5 mg / mL, 1 mg / mL, 0.75 mg / mL, 0.5 mg / mL, 0.25 mg / mL, 0.125 mg / mL, and 0 mg / mL to plot a standard curve. Add 10 μL each of the protein standard (bovine serum albumin) and the test solution to a 96-well plate, in triplicate, add 300 μL of Coomassie Brilliant Blue G250 staining solution (detergent compatible), react at room temperature for 20 min, and measure the absorbance at an A595 nm wavelength. Calculate the protein concentration in each test sample using the standard curve plotted with the protein standard. The greater the degree of solubility, the stronger the interaction between the sample and Zein, and the stronger the irritant effect. The results are shown in Table 3.

[0088] 3. Surfactants can affect the skin barrier function. Testing the effect of shower gel on the skin barrier can reflect its impact on the skin barrier.

[0089] The specific testing includes the following steps: For sensitive skin (TEWL ≥ 20g / hm) 2Six subjects per group underwent a transdermal water loss test. Subjects 40-45 used the sample from Application Example 1 on the inner side of their left forearm and the control sample from Application Example 1 on their right side; subjects 46-51 used the sample from Application Example 2 on the inner side of their left forearm and the control sample from Application Example 2 on their right side; and so on. Subjects 112-117 used the blank application sample on the inner side of their left forearm and the control sample from Application Example 13 on their right side. On the day of the test, no product was applied to the test area. After washing, subjects sat quietly for 20 minutes in a constant temperature and humidity room at 21±1℃ and 50±10%. The transdermal water loss probe was used. The TM Hex (Courage+Khazaka) measured the initial TEWL value for each volunteer and averaged the six results. Subjects washed the inside of their forearms twice daily (morning and evening) with the sample of shower gel for 28 consecutive days, and then measured the TEWL value of the tested area again after use; subsequently, the rate of change was calculated; TEWL value change rate (%) = (initial TEWL value - post-use TEWL value) / initial TEWL value × 100%;

[0090] A larger and positive TEWL value change rate indicates that the sample is friendly to the skin barrier and has a certain repair ability; a negative TEWL value change rate indicates that the sample damages the skin barrier and further aggravates skin problems. The results are shown in Table 3.

[0091] 4. The skin microecological barrier plays an important role in maintaining skin stability. Beneficial bacteria (Staphylococcus epidermidis) can secrete exogenous antimicrobial peptides to strengthen the skin's immune defense, while harmful bacteria (Staphylococcus aureus) can cause skin papules or pustules. By observing and recording the effects of shower gel on beneficial and harmful bacteria, we can demonstrate its regulatory role on the microecology.

[0092] The specific testing included the following steps: Staphylococcus aureus (ATCC6538) and Staphylococcus epidermidis (CMCC(B)26069) were purchased from Ningbo Taisto Biotechnology Co., Ltd. The Oxford cup method was used for the inhibition zone test. The test bacteria were prepared into a bacterial suspension with PBS at a concentration of 5 × 10⁻⁶. 6 CFU / mL. 100 μL of bacterial suspension was pipetted onto the surface of solidified agar medium (purchased from Guangdong Huankai Microbial Technology Co., Ltd.), spread evenly with a sterile spreader, covered the petri dish, and incubated at 20℃ for 10 min. Finally, a sterile Oxford cup was gently inverted on the surface of the medium, and shower gel sample was added until the liquid level was parallel to the surface of the Oxford cup. The dish was then incubated at 37℃ for 18 h. Criteria for determining the inhibition zone: >20 mm diameter indicates extremely sensitive (++++); 15-20 mm indicates highly sensitive (+++); 10-15 mm indicates moderately sensitive (++); <10 mm indicates low sensitivity (+); 0 mm indicates no inhibitory effect (-). The results are shown in Table 3.

[0093] 5. The foaming ability of a shower gel can be reflected by testing its foam height. The specific test includes the following steps: The foaming performance of the shower gel sample is tested using a Roche foam meter. The sample is prepared into a 400mL 1% test solution using 150ppm hard water. Under room temperature conditions, two 200mL portions of the 400mL solution are drawn off and allowed to flow from a height of 80cm to the bottom of the graduated cylinder. The measured foam height is used as the evaluation index of the sample's foaming power. The results are shown in Table 3.

[0094] Table 3

[0095]

[0096]

[0097] As can be seen from Table 3, when the technical solution provided by this invention is adopted, the resulting shower gel has excellent effects in maintaining skin stability, enhancing skin barrier function, and promoting skin health, while also having good foaming properties. Specifically, the obtained shower gel has a cholesterol dissolution rate of less than 0.025 nmol / L, a PCA dissolution rate of less than 0.019 nmol / L, a protein concentration of less than 1.79 mg / mL, and a TEWL value improvement rate of more than 11.6%. It has no antibacterial effect against Staphylococcus epidermidis, but has an inhibition zone of 15-20 mm or more against Staphylococcus aureus. The foam height is more than 24 cm.

[0098] As can be seen from Application Examples 1-7 and Comparative Application Examples 1-7, the mass fraction of the components and whether or not a certain component is added have a significant impact on product performance. When the mass fraction of the components is further selected within the range of this invention, the overall effect of the obtained product is better. Specifically, the obtained shower gel has a cholesterol dissolution rate of less than 0.018 nmol / L, a PCA dissolution rate of less than 0.008 nmol / L, a protein concentration of less than 1.35 mg / mL, a TEWL value improvement rate of more than 13.2%, and a foam height of more than 32 cm. As can be seen from Application Example 1 and Comparative Application Examples 1-5, when none of the components of this invention are added, the obtained product... After use, the dissolution rates of cholesterol and PCA increased significantly, and the protein concentration also showed a significant increasing trend. The TEWL value improvement rate was negative, indicating damage to the skin barrier function. Simultaneously, it showed an antibacterial effect against Staphylococcus epidermidis, but the antibacterial effect against Staphylococcus aureus decreased, and the foam height also showed a certain degree of reduction. As can be seen from Application Example 1 and Comparative Application Examples 6-7, the effects of this invention cannot be achieved when a certain component is not added and other components are used to make up the proportions. As can be seen from Application Example 1 and Comparative Application Examples 8-13, the effects of this invention cannot be achieved when other components are used to replace the components in this invention.

[0099] As can be seen from Application Examples 1 and 8-9, the type of glycolipid also affects the overall performance of the shower gel. When the glycolipid is further selected as sophorolipid, especially lactone-type sophorolipid, the overall performance of the shower gel is even better.

[0100] Example 2

[0101] This invention investigates the safety of shower gels prepared using application examples, comparative application examples, and blank application examples. The testing method includes the following steps: A chicken embryo chorioallantoic membrane assay is performed, including the following steps: SPF-grade chicken embryos are incubated for 9 days in an incubator at 37.5℃±0.5℃, humidity 70%±5%, and a turntable frequency of 5 times / h. After incubation, the air cell position is marked, the eggshell is removed, and the egg membrane is moistened with 1 mL of physiological saline and then removed to avoid damage to the vascular membrane. A Teflon ring is placed in the yolk position of the chicken embryo. The chicken embryo is placed under a stereomicroscope, and a photograph is recorded before sample loading. 40 μL of sample is added to the Teflon ring, and a photograph is recorded at 30 seconds. Six chicken embryos are prepared in parallel for each sample.

[0102] Results evaluation: The irritancy of the sample was scored based on the bleeding, coagulation and vascular dissolution phenomena. No bleeding, mild bleeding, moderate bleeding and severe bleeding were scored as 0, 1, 2 and 3 points respectively; no coagulation, mild coagulation, moderate coagulation and severe coagulation were scored as 0, 1, 2 and 3 points respectively; no vascular dissolution, mild vascular dissolution, moderate vascular dissolution and severe vascular dissolution were scored as 0, 1, 2 and 3 points respectively.

[0103] Final evaluation score ES calculation formula: ES = total degree of bleeding, blood coagulation, and vascular lysis observed in 6 chicken embryos / 3;

[0104] The scoring table is shown in Table 4, and the obtained results are shown in Table 5.

[0105] Table 4

[0106] Final evaluation score irritation classification ES ≤ 12 no / mild irritation 12 < ES < 16 moderate irritation ES ≥ 16 severe irritation Table

[0107] Table 5

[0108]

[0109] <着

[0110] As can be seen from Table 5, the body wash obtained by the present invention has good safety; among them, the photos of one chicken embryo in Application Example 1 and Comparative Application Example 10 are shown in Figures 1-2 respectively.

[0111] Finally, it should be noted that the above embodiments are used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A surfactant composition, characterized in that, The surfactant composition comprises the following components in parts by weight: 0.5-8 parts sodium lauroyl glutamate, 1-10 parts decyl glucoside, 0.5-8 parts Tween-28, 1-8 parts betaine-type surfactant, 0.1-3 parts glycolipid and 0.05-0.5 parts soybean seed polysaccharide; the mass ratio of the sum of the decyl glucoside and Tween-28 to the soybean seed polysaccharide is 21-180; the total mass percentage of sodium lauroyl glutamate and glycolipid is 16-45% based on the total mass of the surfactant composition; the glycolipid is selected from at least one of sophorolipid and mannoerythritol lipolipid.

2. The surfactant composition according to claim 1, characterized in that, The surfactant composition comprises the following components in parts by weight: 3-6 parts sodium lauroyl glutamate, 4-8 parts decyl glucoside, 2-4 parts Tween-28, 3-6 parts betaine-type surfactant, 0.5-2 parts glycolipid and 0.2-0.4 parts soybean seed polysaccharide.

3. The surfactant composition according to claim 1, characterized in that... The betaine-type surfactant includes at least one of cocoyl hydroxysulfonate betaine, cocamidopropyl hydroxysulfonate betaine, cocamidopropyl betaine, lauryl hydroxysulfonate betaine, lauridopropyl hydroxysulfonate betaine, and lauridopropyl betaine.

4. The surfactant composition according to claim 3, characterized in that, The glycolipid is a lactone-type sophorolipid.

5. The use of the surfactant composition according to any one of claims 1-4 in the preparation of personal care products.

6. A shower gel, characterized in that, The shower gel comprises a surfactant composition as described in any one of claims 1-4.

7. The shower gel according to claim 6, characterized in that, The shower gel comprises the following components by weight percentage: 25-50% surfactant composition as described in any one of claims 1-4, 0.5-2% emulsifier, 0.3-1.5% preservative, 0.05-2% thickener, 0.05-0.6% pH adjuster, 0.01-0.05% chelating agent, and the balance being water.

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