Spray freeze drying system

Abstract

The invention provides a spray freeze drying system. The spray freezing and drying system comprises a spray freezing device which is provided with a spray freezing chamber and a material receiving opening, and the material receiving opening is located in the bottom of the spray freezing chamber, communicates with the spray freezing chamber and is used for outputting frozen materials; the vacuum freeze-drying device comprises a freeze-drying bin and a plurality of material bearing pieces, the freeze-drying bin is provided with a freeze-drying cavity used for conducting vacuum freeze-drying on materials, and the material bearing pieces are movably placed in the freeze-drying cavity; and the carrying device is used for carrying the material bearing pieces, so that any one of the multiple material bearing pieces has a first position located below the material receiving opening and a second position located in the freeze-drying cavity, and when the material bearing pieces are located at the first position, the sides, used for bearing the materials, of the material bearing pieces are in sealing fit with the material receiving opening. According to the technical scheme, the problem that in the prior art, a spray freeze-drying system is difficult to produce in a large scale is solved.

Description

Technical Field

[0001] This invention relates to the field of spray freeze-drying technology, and more specifically, to a spray freeze-drying system. Background Technology

[0002] In the pharmaceutical field, freeze-drying is a crucial method for preserving heat-sensitive drugs, biological agents, and vaccines. Drugs treated with freeze-drying retain certain activity and stability, extending their shelf life and expiration date. It plays an irreplaceable role in the production and storage of some high-value-added biopharmaceuticals and vaccines. With the rapid development of the biopharmaceutical industry, the demand for freeze-drying technology continues to grow. Furthermore, researchers frequently utilize freeze-drying technology in areas such as biological sample preservation, microbial strain preservation, and genetic engineering research. This facilitates the long-term preservation and transportation of biological samples while maintaining their activity and integrity, providing vital support for the smooth progress of scientific research.

[0003] However, the freeze-drying industry currently faces many unresolved problems, such as: excessive investment in freeze-drying equipment, including the equipment itself, auxiliary equipment such as vacuum pumps and condensers, and installation costs; high operating and maintenance costs, requiring regular replacement of vacuum pump oil and calibration of sensors; excessively long drying times, ranging from tens of hours to several days or even longer to complete a batch, resulting in relatively low production efficiency. Compared to other drying methods such as spray drying, the extremely slow drying speed becomes a bottleneck for scaling up production; and low integration, as existing freeze dryers on the market require manual operation for loading and unloading, sometimes taking more than ten hours in actual production, indicating excessive manual intervention and low overall equipment integration.

[0004] Spray freeze-drying technology can solve some of the aforementioned pain points and challenges. Spray freeze-drying (SFD) is a technology that combines spray freezing and vacuum freeze-drying, primarily used to process heat-sensitive, easily oxidized, or substances that require the preservation of specific structures (such as porosity or high solubility). Its core principle is to first atomize liquid materials into tiny droplets and then instantly freeze them, followed by sublimation under vacuum conditions to remove ice crystals, ultimately obtaining a dry powder. It can significantly shorten drying time and improve drying efficiency. However, spray freeze-drying has a fatal drawback: low production capacity and difficulty in automation.

[0005] Chinese Patent Publication No. CN115289788B discloses a vacuum spray freeze dryer, including a feeding device and a vacuum drying device. The feeding device includes a feeding pump and a pretreatment mechanism. The pretreatment mechanism is connected to the feeding pump and the vacuum drying device. The pretreatment mechanism is used to pre-cool the material. The vacuum drying device includes a quartz glass cover and several annular infrared heaters. The several annular infrared heaters are sleeved on the outer wall of the quartz glass cover to form a heating sublimation zone inside the quartz glass cover. The material is pre-cooled by a pretreatment mechanism to bring its temperature closer to its freezing point. After entering the vacuum drying unit, it first solidifies into small ice crystals in the heat exchange zone. Then, as it falls and passes through the heating sublimation zone, it is dried and sublimated by a ring-shaped infrared heater, avoiding uneven heating and low heat exchange efficiency. Although the above technology can achieve continuous operation throughout the entire process, it still has many technical drawbacks that restrict practical application and capacity improvement. For example, the heat exchange zone and the heating sublimation zone are in the same vacuum system. Under the action of vacuum suction, the newly atomized droplets will accelerate through the heat exchange zone and the heating sublimation zone. If the flow rate is increased to increase capacity, the residence time of droplets in the freezing and freeze-drying zones will become shorter, leading to freeze-drying defects. Therefore, to achieve a qualified freeze-drying effect, the feed flow rate will be limited, and the capacity will be restricted, making it difficult to scale up production. Summary of the Invention

[0006] The main objective of this invention is to provide a spray freeze-drying system to solve the problem that existing spray freeze-drying systems are difficult to scale up for production.

[0007] To achieve the above objectives, the present invention provides a spray freeze-drying system, comprising: a spray freezing device having a spray freezing chamber and a material receiving port, the material receiving port being located at the bottom of the spray freezing chamber and communicating with the spray freezing chamber, the material receiving port being used to output frozen material; a vacuum freeze-drying device including a freeze-drying chamber and a plurality of material supports, the freeze-drying chamber having a freeze-drying chamber for vacuum freeze-drying the material, the plurality of material supports being movably placed within the freeze-drying chamber; and a conveying device for conveying the material supports, such that any one of the plurality of material supports has a first position located below the material receiving port and a second position located within the freeze-drying chamber, wherein when the material support is in the first position, the side of the material support used to support the material is sealed to the material receiving port.

[0008] Furthermore, the freeze-drying chamber has a placement opening communicating with the freeze-drying chamber. The handling device includes: a handling mechanism, which is correspondingly arranged to the material receiving opening and is located below the material receiving opening. The handling mechanism has a handling section, which is vertically and vertically arranged relative to the spray freezing device along a first direction so that the handling section can approach or move away from the material receiving opening; a material transfer mechanism, located on the side where the placement opening of the freeze-drying chamber is located, which has a material transfer section, capable of placing and removing any material support in the freeze-drying chamber; and a conveying mechanism, located between the handling mechanism and the material transfer mechanism, which is used to convey the material support. The material support reciprocates between a first position and a second position via the handling mechanism, the conveying mechanism, and the material transfer mechanism, with the first direction forming an angle with the conveying direction of the conveying mechanism.

[0009] Furthermore, the conveying mechanism includes: a first support; a conveying platform forming a conveying section; a first lifting member disposed on the first support, the first lifting member having a first lifting end that is vertically and vertically disposed relative to the first support in a first direction, the conveying platform being connected to the first lifting end; and a first guide member including a first guide member and a first sliding member, the first guide member being disposed on the first support, one end of the first sliding member being connected to the conveying platform, and the other end of the first sliding member being slidably engaged with the first guide member.

[0010] Furthermore, the conveying mechanism also includes two clamping components, which are spaced apart along the second direction. The first direction, the second direction, and the conveying direction of the conveying mechanism are arranged at angles to each other. The clamping components include an mounting component, a screwing component, a screw, and a limiting component. The mounting component is connected to the conveying part. The screw passes through the mounting component and is threadedly engaged with the mounting component. One end of the screw is connected to the screwing component, and the other end of the screw is rotatably connected to the limiting component. The two limiting components are arranged facing each other and form a limiting space for limiting the material support component.

[0011] Furthermore, the conveying mechanism also includes a pushing component, which includes: a mounting base disposed on the conveying section, the mounting base being located on the side of the limiting space opposite to the conveying mechanism; a driving member disposed on the mounting base, the driving member having a driving end movably disposed relative to the mounting base along the conveying direction; and a pushing member connected to the driving end, the pushing member being able to extend into or out of the limiting space.

[0012] Furthermore, the side of the conveying unit facing the material receiving port is provided with a clearance groove, the area of ​​the projection area of ​​the material support on the conveying unit is larger than the area of ​​the clearance groove, and the clearance groove is within the projection area.

[0013] Furthermore, the conveying mechanism includes: a support frame; a first drive unit disposed on the support frame; a plurality of first rolling elements rotatably disposed on the support frame, arranged sequentially along the conveying direction, the first drive unit being used to drive the plurality of first rolling elements to rotate; and a first conveyor belt located on the outer periphery of the plurality of first rolling elements, the first conveyor belt being used to convey material support elements.

[0014] Furthermore, the material transfer mechanism includes: a second support, located below the freeze-drying chamber; a material transfer component having a material transfer section; a second lifting component disposed on the second support, the second lifting component having a second lifting end that is vertically and vertically disposed relative to the second support in a first direction, the material transfer component being connected to the second lifting end; and a second guide component, including a second guide member and a second sliding member, the second guide member being disposed on the second support, one end of the second sliding member being connected to the material transfer component, and the other end of the second sliding member being slidably engaged with the second guide member.

[0015] Furthermore, the material support member is provided with a groove, and the material transfer component includes: a mounting frame connected to the second lifting end; a transfer platform disposed on the mounting frame, the transfer platform having a transfer surface for transferring the material support member along the conveying direction; a telescopic member disposed on the mounting frame, the telescopic member having a telescopic end movable relative to the transfer platform along a second direction; and a material transfer member connected to the telescopic end, the material transfer member cooperating with the groove to be able to pull the material support member from the freeze-drying chamber onto the transfer surface, the material transfer member forming a material transfer section.

[0016] Furthermore, the transfer platform includes: a second drive unit disposed on the mounting frame; a plurality of second rolling elements rotatably disposed on the mounting frame, the plurality of second rolling elements being arranged sequentially along the conveying direction, the second drive unit being used to drive the plurality of second rolling elements to rotate; and a second conveyor belt located on the outer periphery of the plurality of second rolling elements, the upward-facing side of the second conveyor belt forming a transfer surface.

[0017] Furthermore, an annular groove is provided at the end where the material receiving port is located, and a sealing element is provided on the side of the annular groove facing the conveying mechanism. The open end of the material support extends into the annular groove and is sealed with the sealing element.

[0018] Furthermore, the vacuum freeze-drying apparatus also includes: a vacuum pump; a cold trap having a cooling chamber, the outlet of the cooling chamber being connected to the vacuum pump, and the inlet of the cooling chamber being connected to the freeze-drying chamber; and a compressor for supplying the cooling medium to the refrigeration coils of the freeze-drying chamber and the refrigeration coils of the cold trap.

[0019] By applying the technical solution of this invention, compared with the problem of existing spray freeze-drying systems being difficult to scale up due to the limitation of feed flow rate, this application separates the spray freezing device and the vacuum freeze-drying device. That is, the spray freezing device is not in a vacuum environment. In this way, the feed flow rate is not affected by the vacuum force. The material support component, which has been pre-cooled in the freeze-drying chamber, is automatically moved to the material receiving port by the conveying device. The spray freezing device rapidly freezes the liquid atomized material by direct cooling with liquid nitrogen. The frozen material in the spray freezing chamber falls onto the material support component through the material receiving port. Then, the material support component with the frozen material is automatically moved to the freeze-drying chamber of the vacuum freeze-drying device by the conveying device. The above steps are repeated until all material support components in the freeze-drying chamber are filled with material. Then, the material support component in all material support components is vacuum freeze-dried by the freeze-drying chamber. In this way, the spray freezing method can not only improve the freezing efficiency, but also the freeze-drying chamber can freeze-dry multiple batches and layers of material at one time. The degree of automation is high, the drying time can be shortened, and the drying efficiency can be improved. This enables scale-up production and increases the production capacity of the spray freeze-drying system. Attached Figure Description

[0020] The accompanying drawings, which form part of this application, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. In the drawings:

[0021] Figure 1 A schematic diagram of an embodiment of the spray freeze-drying system of the present invention is shown;

[0022] Figure 2 It shows Figure 1 Enlarged view of point A in the spray freeze-drying system;

[0023] Figure 3 It shows Figure 1 A schematic diagram of the conveying mechanism of a spray freeze-drying system;

[0024] Figure 4 It shows Figure 1 Enlarged view of section B of the spray freeze-drying system;

[0025] Figure 5 It shows Figure 1 A schematic diagram of the material transfer component of a spray freeze-drying system;

[0026] Figure 6 It shows Figure 5 A left view of one state of the material transfer component;

[0027] Figure 7 It shows Figure 5 A left view of another state of the material transfer component;

[0028] Figure 8 It shows Figure 1 A schematic diagram of the material support component of a spray freeze-drying system;

[0029] Figure 9 It shows Figure 8 Left view of the material support component;

[0030] Figure 10 It shows Figure 8 A sectional view of the material support component;

[0031] Figure 11 A schematic diagram of the material after experimental testing according to this application is shown.

[0032] The above figures include the following reference numerals:

[0033] 11. Spray freezing chamber; 12. Material receiving port; 121. Annular groove; 122. Sealing element; 21. Freeze-drying chamber; 22. Material support element; 221. Groove; 31. Vacuum pump; 32. Cold trap; 33. Compressor; 50. Handling device; 51. Handling mechanism; 511. First support; 512. Handling section; 513. First lifting component; 514. First guide; 515. First sliding component; 516. Mounting component; 517. Tightening component; 518. Screw; 519. Limiting component; 52. Transfer mechanism; 521. Second support; 522. Second lifting component; 523. Second guide; 524. Second sliding component; 53. Conveying element; 531. Feeding mechanism; 532. Support frame; 533. First drive unit; 533. First rolling element; 534. First conveyor belt; 54. Mounting base; 55. Drive element; 56. Pushing element; 57. Clearance groove; 581. Mounting frame; 582. Transfer surface; 583. Telescopic element; 584. Transfer unit; 585. Second drive unit; 586. Second rolling element; 587. Second conveyor belt; 71. Downward liquid nitrogen inlet; 72. Opposite liquid nitrogen inlet; 73. Lower cavity temperature sensor; 74. Upper cavity temperature sensor; 75. Feed peristaltic pump; 76. Two-fluid needle nozzle; 77. Atomized liquid airflow inlet; 78. Needle airflow inlet; 79. Baffle. Detailed Implementation

[0034] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0035] like Figures 1 to 10As shown, an embodiment of the present invention provides a spray freeze-drying system, comprising: a spray freezing device having a spray freezing chamber 11 and a material receiving port 12, the material receiving port 12 being located at the bottom of the spray freezing chamber 11 and communicating with the spray freezing chamber 11, the material receiving port 12 being used to output frozen material; a vacuum freeze-drying device including a freeze-drying chamber 21 and a plurality of material supports 22, the freeze-drying chamber 21 having a freeze-drying chamber for vacuum freeze-drying the material, the plurality of material supports 22 being movably placed in the freeze-drying chamber; and a conveying device 50 for conveying the material supports 22, such that any one of the plurality of material supports 22 has a first position located below the material receiving port 12 and a second position located in the freeze-drying chamber, the material support 22 being in the first position, the side of the material support 22 used for supporting the material being sealed to the material receiving port 12.

[0036] In the above technical solution, compared with the problem of existing spray freeze-drying systems being difficult to scale up due to the limited feed flow rate, in this application, the spray freezing device and the vacuum freeze-drying device are set up separately, that is, the spray freezing device is not in a vacuum environment. In this way, the feed flow rate is not affected by the vacuum force, and the material support 22, which has been pre-cooled by the freeze-drying chamber 21, is automatically moved to the material receiving port 12 by the conveying device 50. The spray freezing device rapidly freezes the liquid atomized material by direct cooling with liquid nitrogen. The material frozen in the spray freezing chamber 11 falls onto the material support 22 through the material receiving port 12. Then, the material support 22 containing the frozen material is automatically moved to the freeze-drying chamber 21 of the vacuum freeze-drying device by the conveying device 50. The above steps are repeated until all the material support 22 in the freeze-drying chamber 21 contains material. Then, the material in all the material support 22 is vacuum freeze-dried by the freeze-drying chamber 21. In this way, the spray freezing method can not only improve the freezing efficiency, but also the freeze-drying chamber 21 can freeze-dry multiple batches and layers of material at one time. The degree of automation is high, the drying time can be shortened, and the drying efficiency can be improved. This enables scale-up production and increases the production capacity of the spray freeze-drying system.

[0037] Furthermore, this application completes the process through atomization, freezing, transfer, and multi-layer vacuum freeze-drying. This system can combine the two processes of spray freezing and vacuum freeze-drying to achieve complete continuity and intelligence in the transfer, loading and unloading, and drying processes. It can expand the overall capacity and output of spray freeze-drying equipment while shortening the drying time and improving the drying efficiency, thus solving the problem that the existing spray freeze-drying system is always in the pilot stage and has low capacity.

[0038] Chinese patent CN214172702U discloses a spray freeze-drying system, including a freeze-drying chamber, a first cold trap, a second cold trap, a first isolation valve, a second isolation valve, and an atomizing feed device. The first cold trap is installed on one side of the freeze-drying chamber via the first isolation valve, and the second cold trap is installed on the other side of the freeze-drying chamber via the second isolation valve. The atomizing feed device is located at the top of the freeze-drying chamber, and a discharge port with a discharge valve is located at the bottom of the freeze-drying chamber. This spray freeze-drying system has advantages such as the ability to quickly and stably switch between cold traps, which is conducive to achieving uninterrupted drying. However, its overall application is still quite difficult. For example, the freezing chamber freezes the atomized droplets through heat exchange via the jacket wall temperature, and indirect heat exchange restricts the increase in production capacity. Switching to vacuum in the transition chamber can easily cause ice particles to collide and squeeze, damaging the ice-shaped skeleton and affecting freeze-drying efficiency. Furthermore, it is difficult to monitor the freezing effect of the material during the freezing process. This application uses liquid nitrogen direct injection to freeze atomized droplets, which has high freezing efficiency. In addition, the spray freezing device and the vacuum freeze drying device are set up separately, and the material after spray freezing falls onto the material support 22 and is transported by the conveying device 50. During this process, the freezing state of the material can be effectively observed, and the operation is simple.

[0039] In existing technologies, due to limitations in the drying principle, the production capacity of spray freeze drying is relatively low. Furthermore, spray freeze drying is difficult to achieve in a continuous, automated, and integrated manner, requiring manual intervention during loading and unloading, which significantly leads to unnecessary labor waste and further increases costs. In contrast, in this application, the spray-frozen material falls onto the material support 22 and is conveyed by the handling device 50, eliminating the need for manual intervention. This allows for continuous, automated, and integrated operation, greatly reducing unnecessary labor waste and further lowering costs.

[0040] In some embodiments, the material support 22 is a pallet.

[0041] like Figures 1 to 7As shown, in an embodiment of the present invention, the freeze-drying chamber 21 has a placement opening communicating with the freeze-drying chamber. The conveying device 50 includes: a conveying mechanism 51, which is correspondingly arranged with the material receiving port 12 and is located below the material receiving port 12. The conveying mechanism 51 has a conveying part 512, which is vertically and vertically arranged relative to the spray freezing device along a first direction so that the conveying part 512 can approach or move away from the material receiving port 12; a material transfer mechanism 52, located on the side where the placement opening of the freeze-drying chamber 21 is located, which has a material transfer part 584, which can put back and take out any material support 22 in the freeze-drying chamber; and a conveying mechanism 53, located between the conveying mechanism 51 and the material transfer mechanism 52. The conveying mechanism 53 is used to convey the material support 22. The material support 22 reciprocates between a first position and a second position via the conveying mechanism 51, the conveying mechanism 53, and the material transfer mechanism 52. The first direction is set at an angle to the conveying direction of the conveying mechanism 53.

[0042] In the above technical solution, after the material is frozen in the spray freezing chamber 11, it falls into the material support 22. The conveying mechanism 51 lifts the material support 22 from the first position below the spray freezing chamber 11 to the position where it docks with the conveying mechanism 53. Then, the material support 22 is conveyed by the conveying mechanism 53 to the position of the transfer mechanism 52. The transfer mechanism 52 puts the material support 22 into the freeze-drying chamber of the freeze-drying chamber 21 for vacuum freeze-drying. In this way, through the lifting of the conveying part 512 of the conveying mechanism 51 and the transfer part 584 of the transfer mechanism 52, the material support 22 can be automatically transferred between the two stages of spray freezing and vacuum freeze-drying. The conveying mechanism 53 ensures the smooth transport of the material support 22 between the conveying mechanism 51 and the transfer mechanism 52, thereby improving the continuity and automation level of material handling, enabling scale-up production, and reducing manual intervention to lower production costs.

[0043] like Figure 2 As shown, in an embodiment of the present invention, the conveying mechanism 51 includes: a first support 511; a conveying platform forming a conveying section 512; a first lifting member 513 disposed on the first support 511, the first lifting member 513 having a first lifting end that is vertically and vertically disposed relative to the first support 511 along a first direction, the conveying platform being connected to the first lifting end; and a first guide member including a first guide member 514 and a first sliding member 515, the first guide member 514 being disposed on the first support 511, one end of the first sliding member 515 being connected to the conveying platform, and the other end of the first sliding member 515 being slidably engaged with the first guide member 514.

[0044] In the above technical solution, the first lifting component 513 drives the conveying part 512 to rise or fall, and the first guiding component can ensure that the conveying part 512 moves smoothly along the first direction so that the conveying part 512 can rise to the position of the material receiving port 12, or the conveying part 512 can fall to the position of docking with the conveying mechanism 53, so as to realize the transfer of the material support 22 between the conveying mechanism 53 and the material receiving port 12.

[0045] In some embodiments, the first lifting member 513 is a cylinder.

[0046] like Figure 3 As shown in the embodiment of the present invention, the conveying mechanism 51 further includes two clamping members. The two clamping members are arranged at intervals along the second direction. The first direction, the second direction and the conveying direction of the conveying mechanism 53 are arranged at angles to each other. The clamping members include a mounting member 516, a screwing member 517, a screw 518 and a limiting member 519. The mounting member 516 is connected to the conveying part 512. The screw 518 passes through the mounting member 516 and is threadedly engaged with the mounting member 516. One end of the screw 518 is connected to the screwing member 517, and the other end of the screw 518 is rotatably connected to the limiting member 519. The two limiting members 519 are arranged facing each other and form a limiting space for limiting the material support member 22.

[0047] In the above technical solution, the material support 22 moves onto the conveying part 512. By adjusting the screw 518 through the screwing part 517, the two limiting parts 519 move towards each other, forming a limiting space that matches the outer edge of the material support 22. This effectively limits the material support 22 during the conveying process, ensuring its stability. In this way, through the limiting effect of the clamping components, it is ensured that the material support 22 will not shift or shake during the conveying process, which not only improves the safety and efficiency of the conveying process, but also reduces material loss.

[0048] It should be noted that, as Figure 1 As shown, the first direction, the second direction, and the conveying direction of the conveying mechanism 53 are arranged perpendicularly to each other, with the second direction perpendicular to the direction of the conveying mechanism 53. Figure 1 The paper in question.

[0049] like Figure 1 and Figure 3 As shown, in an embodiment of the present invention, the conveying mechanism 51 further includes a pushing member, which includes: a mounting base 54 disposed on the conveying part 512, the mounting base 54 being located on the side of the limiting space away from the conveying mechanism 53; a driving member 55 disposed on the mounting base 54, the driving member 55 having a driving end movably disposed relative to the mounting base 54 in the conveying direction; and a pushing member 56 connected to the driving end, the pushing member 56 being able to extend into or out of the limiting space.

[0050] In the above technical solution, the limiting member 519 limits the material support member 22, and the driving member 55 can drive the pushing member 56 to extend into the limiting space, so as to smoothly push the material support member 22 onto the conveying mechanism 53, thereby completing the automated transfer of the material support member 22. In this way, the pushing action of the pushing member can be used to smoothly push the material support member 22 out of the limiting space onto the conveying mechanism 53, ensuring the accurate transfer of the material support member 22, improving the transfer efficiency and accuracy of the material support member 22, reducing manual operation, and lowering production costs.

[0051] In some implementations, the drive component 55 is a cylinder.

[0052] like Figure 2 and Figure 3 As shown in the embodiment of the present invention, a clearance groove 57 is provided on the side of the conveying part 512 facing the material receiving port 12. The area of ​​the projection area of ​​the material support member 22 on the conveying part 512 is larger than the area of ​​the clearance groove 57, and the clearance groove 57 is within the projection area. In this way, after the pallet rises to the position abutting against the material receiving port 12, the force is transmitted from the outer edge of the pallet to prevent the bottom surface of the pallet from being deformed by the force.

[0053] In some implementations, the depth of the vent groove 57 is 3 mm.

[0054] It should be noted that the lifting platform is equipped with limit and transportation functions and can prevent pallet deformation. The lifting of the platform is achieved by cylinders and guide columns. The platform is equipped with manually operable and adjustable clamping components. A cylinder is located on the left side of the platform. After the material is received, the pallet is transported to the conveying mechanism 53 by controlling the cylinder. In addition, an anti-gap groove 57 is provided in the center of the platform. This anti-gap groove 57 can prevent the bottom of the pallet from deforming when the pallet is in interference contact with the material receiving port 12, which would eventually lead to unevenness of the bottom of the pallet and affect drying.

[0055] like Figure 1 As shown, in an embodiment of the present invention, the conveying mechanism 53 includes: a support frame 531; a first driving part 532 disposed on the support frame 531; a plurality of first rolling elements 533 rotatably disposed on the support frame 531, and arranged sequentially along the conveying direction, the first driving part 532 being used to drive the plurality of first rolling elements 533 to rotate; and a first conveyor belt 534 located on the outer periphery of the plurality of first rolling elements 533, the first conveyor belt 534 being used to convey the material support member 22.

[0056] In the above technical solution, the conveying unit 512 or the transfer unit 584 smoothly places the material support 22 on the first conveyor belt 534, causing the first drive unit 532 to rotate in both directions, driving multiple first rolling elements 533 to rotate, and driving the first conveyor belt 534 to transport the material support 22 between the transfer mechanism 52 and the conveying mechanism 51, thus completing the automated transfer of the material support 22. In this way, continuous and automated transfer of materials between different processing stages can be ensured, improving the efficiency and automation level of material transfer, reducing manual operation, and lowering production costs.

[0057] In some embodiments, the first rolling element 533 is a pulley, the first conveyor belt 534 is a belt, and the first drive unit 532 includes a plurality of motors, the output shafts of the plurality of motors being drivenly connected to the plurality of first rolling elements 533 respectively; or, the first drive unit 532 is a single motor, the output shaft of the single motor being drivenly connected to one of the plurality of first rolling elements 533, and the remaining first rolling elements 533 among the plurality of first rolling elements 533 are all driven wheels.

[0058] like Figure 1 , Figure 4 and Figure 5 As shown, in an embodiment of the present invention, the material transfer mechanism 52 includes: a second support 521 located below the freeze-drying chamber 21; a material transfer component having a material transfer portion 584; a second lifting component 522 disposed on the second support 521, the second lifting component 522 having a second lifting end that is vertically and vertically disposed relative to the second support 521 along a first direction, the material transfer component being connected to the second lifting end; and a second guide component including a second guide member 523 and a second sliding member 524, the second guide member 523 being disposed on the second support 521, one end of the second sliding member 524 being connected to the material transfer component, and the other end of the second sliding member 524 being slidably engaged with the second guide member 523.

[0059] In the above technical solution, the second lifting component 522 of the transfer mechanism 52 can drive the transfer part 584 to move until it is aligned with the material support 22 on the first conveyor belt 534. After the first conveyor belt 534 uses inertia to transport the material support 22 onto the transfer component, the second lifting component 522 can drive the transfer component to rise. Subsequently, the transfer part 584 accurately moves the material support 22 into the freeze-drying chamber of the freeze-drying chamber 21. The second guide component can ensure that the transfer component moves smoothly along the first direction. In this way, the lifting function of the second lifting component 522 and the guiding function of the second guide component can be used to ensure that the transfer component can accurately move the material support 22 to the second position while maintaining the stability of the material. This improves the accuracy and automation level of material transfer, reduces manual operation, and lowers production costs.

[0060] In some embodiments, the second lifting member 522 is a cylinder.

[0061] It should be noted that the first conveyor belt 534 can use inertia to transport the material support 22 to the material transfer component or the handling unit 512.

[0062] like Figure 1 , Figure 4 as well as Figures 5 to 9 As shown, in an embodiment of the present invention, the material support member 22 is provided with a groove 221, and the material transfer component includes: a mounting frame 581 connected to the second lifting end; a transfer platform disposed on the mounting frame 581, the transfer platform having a transfer surface 582 for transferring the material support member 22 along the conveying direction; a telescopic member 583 disposed on the mounting frame 581, the telescopic member 583 having a telescopic end movably disposed relative to the transfer platform along a second direction; and a material transfer member connected to the telescopic end, the material transfer member cooperating with the groove 221 to be able to pull the material support member 22 from the freeze-drying chamber onto the transfer surface 582, the material transfer member forming a material transfer part 584.

[0063] In the above technical solution, the telescopic component 583 of the transfer component drives the transfer component to extend into the groove 221 on the material support component 22. Then, the transfer component smoothly pulls the material support component 22 in the freeze-drying chamber onto the transfer surface 582. The material support component 22 in the freeze-drying chamber is transferred to the transfer surface 582 and then conveyed to the conveying unit 512 by the transfer surface 582. Similarly, the first conveyor belt 534 conveys the material support component 22 to the transfer surface 582. The telescopic component 583 of the transfer component drives the transfer component to push the material support component 22 into the freeze-drying chamber 21 for vacuum freeze-drying. In this way, by cooperating with the groove 221 on the material support component 22 and utilizing the telescopic function of the telescopic component 583, the material support component 22 can be smoothly pulled onto the transfer surface or pushed into the freeze-drying chamber 21. This ensures the automated transfer of materials between different processing stages, improves the efficiency and automation level of material transfer, reduces manual operation, and lowers production costs.

[0064] In some embodiments, the telescopic member 583 is a cylinder.

[0065] It should be noted that by controlling the movement of the transfer platform in the first direction and the movement of the transfer component in the second direction, the transfer component can be inserted into the groove 221 on the material support component 22.

[0066] like Figure 1 , Figure 4 as well as Figures 5 to 9As shown, in an embodiment of the present invention, the transfer platform includes: a second drive unit 585 disposed on a mounting frame 581; a plurality of second rolling elements 586 rotatably disposed on the mounting frame 581, the plurality of second rolling elements 586 being arranged sequentially along the conveying direction, the second drive unit 585 being used to drive the plurality of second rolling elements 586 to rotate; and a second conveyor belt 587 located on the outer periphery of the plurality of second rolling elements 586, the upward-facing side of the second conveyor belt 587 forming a transfer surface 582.

[0067] In the above technical solution, the first conveyor belt 534 transports the material support 22 onto the second conveyor belt 587, causing the second drive unit 585 to rotate in both directions, driving multiple second rolling elements 586 to rotate, which in turn drives the second conveyor belt 587 to transport the material support 22, thus completing the automated transfer of the material support 22. In this way, the second drive unit 585 can drive the second rolling elements 586 to rotate, which in turn drives the second conveyor belt 587 to smoothly transfer the material support 22, ensuring continuous and automated transfer of materials between different processing stages, improving the efficiency and automation level of material transfer, reducing manual operation, and lowering production costs.

[0068] In some embodiments, the second rolling element 586 is a pulley, the second conveyor belt 587 is a belt, and the second drive unit 585 includes a plurality of motors, the output shafts of the plurality of motors being drivenly connected to the plurality of second rolling elements 586 respectively; or, the second drive unit 585 is a single motor, the output shaft of the single motor being drivenly connected to one of the plurality of second rolling elements 586, and the remaining second rolling elements 586 among the plurality of second rolling elements 586 are all driven wheels.

[0069] like Figure 2 and Figure 10 As shown in the embodiment of the present invention, an annular groove 121 is provided at the end of the material receiving port 12, and a sealing member 122 is provided on the side of the annular groove 121 facing the conveying mechanism 51. The open end of the material support member 22 extends into the annular groove 121 and is sealed with the sealing member 122.

[0070] In the above technical solution, after the material is frozen, the open end of the material support 22 extends into the annular groove 121 and forms a sealing fit with the sealing element 122. Through the setting of the annular groove 121 and the sealing element 122, it is ensured that the material support 22 forms a seal when it docks with the material receiving port 12 of the spray freezing device, preventing air leakage during the material transfer process and ensuring the vacuum conditions of the drying process. In this way, the sealing performance and drying efficiency of the material transfer process are improved, and the loss and contamination of the material during the transfer process are reduced.

[0071] In some embodiments, the material support 22 is a pallet, such as Figures 8 to 10As shown, when the pallet contacts the seal 122 of the annular groove 121, its flanged structure can largely ensure the sealing performance between the pallet and the seal 122. In addition, the groove 221 on the outside of the pallet can play a role in stabilizing the translation during the automatic feeding and discharging stage. The second conveyor belt 587 of the transfer platform is controlled to transport the material. The second conveyor belt 587 is equipped with a material transfer component controlled by the telescopic component 583. During the process of taking out / placing the pallet, the material transfer component cooperates with the specially structured pallet. The automatic feeding and discharging purpose is achieved by adjusting the length of the telescopic component 583, the height of the second conveyor belt 587, and the height of the partition inside the freeze-drying chamber 21.

[0072] like Figure 1 As shown, in an embodiment of the present invention, the vacuum freeze-drying apparatus further includes: a vacuum pump 31; a cold trap 32 having a cooling chamber, the outlet of the cooling chamber being connected to the vacuum pump 31, and the inlet of the cooling chamber being connected to the freeze-drying chamber; and a compressor 33 for supplying cooling medium to the refrigeration coils of the freeze-drying chamber 21 and the refrigeration coils of the cold trap 32.

[0073] In the above technical solution, the vacuum pump 31 is activated to provide a high vacuum environment for the freeze-drying chamber, while the cooling chamber of the cold trap 32 provides low-temperature conditions. The compressor 33 provides a cooling medium for the refrigeration coil, ensuring that the material is dried efficiently under vacuum and low-temperature conditions, ultimately yielding high-quality dried material. Thus, by setting up the vacuum pump 31 and the cold trap 32, a high vacuum environment and low-temperature conditions are provided for the freeze-drying chamber of the freeze-drying chamber 21, and the compressor 33 provides a cooling medium for the refrigeration coil, ensuring the efficient execution of the freeze-drying process, improving the efficiency and quality of material drying, shortening the drying time, and reducing production costs.

[0074] It should be noted that, in addition to achieving equipment integration and automation, the spray freeze-drying system of the present invention can also increase the equipment capacity of spray freeze-drying, thereby achieving capacity expansion and improving drying efficiency and shortening drying time during the drying stage.

[0075] The actual production process of this application is as follows:

[0076] First, the pre-cooling stage: The compressor 33 is turned on to pre-cool the trays in the cold trap 32 and freeze-drying chamber 21. The freeze-drying chamber 21 has multiple layers of partitions 79 to support the trays. Each partition 79 contains a serpentine refrigeration coil. Both the cold trap 32 and the refrigeration coils in the partitions 79 are connected to the compressor 33. The temperature of the cold trap coils must reach below -80℃, and the temperature of the refrigeration coils in the partitions 79 must reach below -50℃. After these two temperatures are reached, the compressor 33 continues to run until drying is complete, maintaining the cold trap temperature at -80℃ throughout the process. The temperature of the partitions 79 is adjusted in real time according to different freeze-drying programs. During the pre-cooling stage, the trays are placed above the partitions 79 in the freeze-drying chamber for pre-cooling.

[0077] Second, the pallet transfer stage: When the temperature of the pallet on the partition 79 drops to -50℃, it needs to be transported to the spray freezing chamber 11 by the handling device 50. The specific operation steps are as follows: by adjusting the second lifting component 522 to control the speed of the transfer platform's rise and fall, the pallets are taken out sequentially from top to bottom, starting from the top layer. When the transfer platform rises to the corresponding position, the telescopic component 583 is controlled. The telescopic component 583 controls the forward and backward movement of the transfer component. In addition, a lifting structure is also provided inside the freeze-drying chamber 21 (existing technology can be used, which will not be described in detail here). By controlling the lifting structure, the partition 79 can be moved up and down, so that the transfer component on the telescopic component 583 can be engaged in the groove 22. 1. After the pallet is pulled into position on the second conveyor belt 587 by the material transfer component, the height of the transfer platform is adjusted to be level with the conveying mechanism 53, and then the pallet is transported to the conveying mechanism 53. Finally, the pallet is transported by the conveying mechanism 53 to the lifting platform. The two clamping components can be manually adjusted to limit the space. After the pallet is transported to the platform, the entire platform is raised by the first lifting component 513. When the outer edge of the pallet rises to the sealing end face of the material receiving port 12, the lifting force of the first lifting component 513 is increased to make the open end of the pallet tightly connected with the sealing end of the material receiving port 12. The sealing element 122 is made of low-temperature resistant PTFE material. The outer edge structure of the pallet is as follows: Figure 10 As shown, this ensures the airtightness of the process, and the tray movement phase is completed.

[0078] Third, the atomization freezing stage: Open the cryogenic solenoid valves on the downward-spraying liquid nitrogen inlet 71 (existing technology can be used, which will not be described in detail here) and the opposing liquid nitrogen inlet 72, and open the Dewar canister containing liquid nitrogen with a pressure of 1.5 MPa. Liquid nitrogen enters the spray freezing chamber, and the temperature inside the chamber begins to drop. During this process, the opening and closing of the cryogenic solenoid valves on the two liquid nitrogen nozzles are adjusted by observing the temperature changes of the lower chamber temperature sensor 73 and the upper chamber temperature sensor 74. If the temperature of the lower chamber is too low and the temperature of the upper chamber is too high during actual operation, the cryogenic solenoid valve on the pipeline of the downward-spraying liquid nitrogen inlet 71 needs to be closed, while the cryogenic solenoid valve on the pipeline of the opposing liquid nitrogen inlet 72 (existing technology can be used, which will not be described in detail here) is kept closed. Conversely, the cryogenic solenoid valve on the pipeline of the downward-spraying liquid nitrogen inlet 71 is opened, and the cryogenic solenoid valve on the pipeline of the opposing liquid nitrogen inlet 72 is closed. When the temperature of both the upper and lower chambers is 30° below the eutectic point of the material to be frozen, the feeding atomization operation can be performed. The liquid feed is delivered to the two-fluid needle nozzle 76 (existing technology can be used, which will not be described in detail here) by the feed peristaltic pump 75. The gas source is provided by the nitrogen tank. The atomizing liquid airflow inlet 77 and the needle airflow inlet 78 (existing technology can be used, which will not be described in detail here) on the two-fluid needle nozzle 76 are respectively connected to the nitrogen tank. The pipeline is equipped with a solenoid valve. The atomizing liquid airflow inlet 77 (existing technology can be used, which will not be described in detail here) is responsible for atomizing the liquid. The needle airflow inlet 78 controls the opening and closing of the solenoid valve on the pipeline to make the needle in the two-fluid needle nozzle 76 move like a piston to prevent the liquid in the nozzle from freezing and clogging due to low temperature. The atomized fine particles are instantly frozen into 'ice particles' after contact with the low temperature environment through the two-fluid needle nozzle 76. The completely frozen ice particles fall into the pre-cooled tray below the cavity by gravity. After spraying to the required amount, the feed peristaltic pump 75 is turned off, the feed is stopped and the low temperature solenoid valve on the liquid nitrogen pipeline is closed, and the atomization and freezing stage ends.

[0079] Fourth, material transfer stage: The first lifting component 513 controls the transport platform to separate the tray containing the material from the spray freezing chamber 11. After the entire platform is lowered to the same level as the conveying mechanism 53, the pushing component is activated to push the tray onto the conveying mechanism 53. The conveying mechanism 53 is controlled by a motor to transport the tray to the transfer platform. After the tray is in place, the second lifting component 522 controls the entire platform to rise. After rising to the original position, the material transfer component is controlled to push the tray into the freeze-drying chamber 21.

[0080] Then, the first, second, third and fourth processes are repeated on the trays in the freeze-drying chamber 21 until all trays are filled with material. After filling, the vacuum freeze-drying stage begins.

[0081] Fifth, the vacuum freeze-drying stage: After all trays are filled, the door of the freeze-drying chamber 21 automatically closes, the vacuum pump 31 begins vacuuming, and the compressor 33 controls the temperature of the cold trap 32 and the partition 79. The temperature of the partition 79 is set according to the material properties. Since the material in the freeze-drying chamber 21 is granular / spherical, it has an extremely high specific surface area (the surface area per unit mass of material). The sublimation process occurs on the surface of the ice crystals. A larger specific surface area means that more surface area of ​​the ice is exposed to the vacuum in the same amount of time, absorbing heat and sublimating into water vapor. In addition, the gaps between the particles provide a direct, low-resistance escape channel for the water vapor generated by sublimation. The water vapor can leave the particle surface very smoothly and enter the vacuum system. Therefore, compared with traditional freeze-drying equipment, this application can not only shorten the drying time but also greatly expand the production capacity.

[0082] Sixth, receiving stage: After drying is completed, the pressure in the freeze-drying chamber 21 is released, and the second lifting component 522 and the partition 79 of the freeze-drying chamber 21 are controlled to remove the pallet. The removal process is the same as the pallet transfer stage in the second step. After removal, the second conveyor belt 587 is used to transport the pallet to the receiving area located on the right side of the freeze-drying chamber 21 for receiving, thus ending the entire process.

[0083] The biggest problem with existing spray freeze-drying equipment is its low capacity and low scale-up efficiency, making it difficult for companies to invest in production-level operations. Furthermore, spray freeze-drying equipment has remained at the stage of small-scale pilot testing, resulting in slow development. The main problem this patent addresses is that, while retaining the spray freeze-drying process, it expands the capacity of spray freeze-drying equipment to the hundreds of kilograms or even tons. The entire operation process of this patent can be fully automated, continuous, and intelligent through a PLC-controlled automatic program, whereas existing spray freeze-drying equipment is almost entirely manual or even semi-automatic. This patent solves the problem of spray freeze-drying equipment's inability to operate automatically. Figure 11 As shown in the preliminary experimental tests, the overall drying time can be shortened by at least 40% compared to traditional freeze drying, and the material exhibits good overall dispersibility and flowability. The overall production capacity can be expanded to 200kg per batch.

[0084] From the above description, it can be seen that the above embodiments of the present invention achieve the following technical effects: Compared with the problem that the existing spray freeze-drying system is difficult to scale up due to the limited feed flow rate, in this application, the spray freezing device and the vacuum freeze-drying device are set separately, that is, the spray freezing device is not in a vacuum environment. In this way, the feed flow rate is not affected by the vacuum force, and the material support component that has been pre-cooled in the freeze-drying chamber is automatically moved to the material receiving port by the conveying device. The spray freezing device rapidly freezes the liquid atomized material by direct cooling with liquid nitrogen. The material frozen in the spray freezing chamber is then transported through the material receiving port. The material falls onto the receiving port and is then automatically moved by a conveying device into the freeze-drying chamber of the vacuum freeze-drying unit. This process is repeated until all the material supports in the freeze-drying chamber are filled with material. Then, the freeze-drying chamber is used to vacuum freeze-dry all the material in the material supports. In this way, the spray freezing method can not only improve the freezing efficiency, but also allow the freeze-drying chamber to freeze-dry multiple batches and layers of material at one time. The high degree of automation can shorten the drying time and improve the drying efficiency, thereby enabling scale-up production and increasing the capacity of the spray freeze-drying system.

[0085] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A spray freeze-drying system, characterized in that, include: A spray freezing device has a spray freezing chamber (11) and a material receiving port (12). The material receiving port (12) is located at the bottom of the spray freezing chamber (11) and communicates with the spray freezing chamber (11). The material receiving port (12) is used to output frozen material. A vacuum freeze-drying apparatus includes a freeze-drying chamber (21) and a plurality of material supports (22), wherein the freeze-drying chamber (21) has a freeze-drying chamber for vacuum freeze-drying of materials, and the plurality of material supports (22) are movably placed in the freeze-drying chamber; A conveying device (50) is used to convey the material support (22) such that any one of the multiple material support (22) has a first position located below the material receiving port (12) and a second position located in the freeze-drying chamber. When the material support (22) is in the first position, the side of the material support (22) used to support the material is sealed to the material receiving port (12).

2. The spray freeze-drying system according to claim 1, characterized in that, The freeze-drying chamber (21) has a placement opening communicating with the freeze-drying cavity, and the handling device (50) includes: A conveying mechanism (51) is provided corresponding to the material receiving port (12). The conveying mechanism (51) is located below the material receiving port (12). The conveying mechanism (51) has a conveying part (512). The conveying part (512) is provided vertically and vertically relative to the spray freezing device in a first direction so that the conveying part (512) can move closer to or away from the material receiving port (12). The material transfer mechanism (52) is located on the side where the placement port of the freeze-drying chamber (21) is located. The material transfer mechanism (52) has a material transfer part (584) which can put back and take out any of the material support members (22) in the freeze-drying chamber. The conveying mechanism (53) is located between the handling mechanism (51) and the material transfer mechanism (52). The conveying mechanism (53) is used to convey the material support (22). The material support (22) moves back and forth between the first position and the second position via the handling mechanism (51), the conveying mechanism (53) and the material transfer mechanism (52). The first direction is set at an angle to the conveying direction of the conveying mechanism (53).

3. The spray freeze-drying system according to claim 2, characterized in that, The transport mechanism (51) includes: First support (511); A transport table, which forms the transport unit (512). A first lifting component (513) is disposed on the first bracket (511). The first lifting component (513) has a first lifting end that is vertically and vertically disposed relative to the first bracket (511) along the first direction. The transport platform is connected to the first lifting end. The first guide member includes a first guide (514) and a first slider (515). The first guide (514) is disposed on the first bracket (511). One end of the first slider (515) is connected to the transport table, and the other end of the first slider (515) is slidably engaged with the first guide (514).

4. The spray freeze-drying system according to claim 2, characterized in that, The conveying mechanism (51) further includes two clamping components, which are spaced apart along the second direction. The first direction, the second direction and the conveying direction of the conveying mechanism (53) are arranged at an angle to each other. The clamping components include a mounting part (516), a screwing part (517), a screw (518) and a limiting part (519). The mounting part (516) is connected to the conveying part (512). The screw (518) passes through the mounting part (516) and is threadedly engaged with the mounting part (516). One end of the screw (518) is connected to the screwing part (517), and the other end of the screw (518) is rotatably connected to the limiting part (519). The two limiting parts (519) are arranged facing each other and form a limiting space for limiting the material support (22).

5. The spray freeze-drying system according to claim 4, characterized in that, The conveying mechanism (51) further includes a pushing component, the pushing component comprising: Mounting base (54) is provided on the conveying part (512), and the mounting base (54) is located on the side of the limiting space away from the conveying mechanism (53); A drive member (55) is disposed on the mounting base (54), the drive member (55) having a drive end that is movably disposed relative to the mounting base (54) along the conveying direction; A pusher (56) is connected to the drive end, and the pusher (56) can extend into or out of the limiting space.

6. The spray freeze-drying system according to claim 2, characterized in that, The conveying part (512) has a clearance groove (57) on the side facing the material receiving port (12). The area of ​​the projection area of ​​the material support member (22) on the conveying part (512) is larger than the area of ​​the clearance groove (57), and the clearance groove (57) is within the projection area.

7. The spray freeze-drying system according to any one of claims 2 to 6, characterized in that, The conveying mechanism (53) includes: Support frame (531); The first drive unit (532) is disposed on the support frame (531). A plurality of first rolling elements (533) are rotatably disposed on the support frame (531). Along the conveying direction, the plurality of first rolling elements (533) are arranged in sequence, and the first driving unit (532) is used to drive the plurality of first rolling elements (533) to rotate. A first conveyor belt (534) is located on the outer periphery of a plurality of first rolling elements (533), and the first conveyor belt (534) is used to convey the material support (22).

8. The spray freeze-drying system according to any one of claims 2 to 6, characterized in that, The material transfer mechanism (52) includes: The second support (521) is located below the freeze-drying chamber (21); A material transfer component having the material transfer part (584); The second lifting member (522) is disposed on the second bracket (521). The second lifting member (522) has a second lifting end that is vertically and vertically disposed relative to the second bracket (521) along the first direction. The material transfer member is connected to the second lifting end. The second guide member includes a second guide (523) and a second sliding member (524). The second guide (523) is disposed on the second bracket (521). One end of the second sliding member (524) is connected to the material transfer member, and the other end of the second sliding member (524) is slidably engaged with the second guide (523).

9. The spray freeze-drying system according to claim 8, characterized in that, The material support member (22) is provided with a groove (221), and the material transfer component includes: Mounting bracket (581) is connected to the second lifting end; A transfer platform is provided on the mounting frame (581), the transfer platform having a transfer surface (582) for transferring the material support (22) along the conveying direction. Telescopic member (583) is disposed on the mounting frame (581), the telescopic member (583) having a telescopic end that is movably disposed relative to the transfer platform in a second direction; The transfer component is connected to the telescopic end and cooperates with the groove (221) to pull the material support (22) from the freeze-drying chamber onto the transfer surface (582). The transfer component forms the transfer part (584).

10. The spray freeze-drying system according to claim 9, characterized in that, The transfer platform includes: The second drive unit (585) is disposed on the mounting bracket (581); A plurality of second rolling elements (586) are rotatably disposed on the mounting frame (581). Along the conveying direction, the plurality of second rolling elements (586) are arranged in sequence, and the second driving unit (585) is used to drive the plurality of second rolling elements (586) to rotate. The second conveyor belt (587) is located on the outer periphery of the plurality of second rolling elements (586), and the upward side of the second conveyor belt (587) forms the transfer surface (582).

11. The spray freeze-drying system according to any one of claims 2 to 6, characterized in that, The material receiving port (12) is provided with an annular groove (121) at one end. A sealing element (122) is provided on the side of the annular groove (121) facing the conveying mechanism (51). The open end of the material support (22) extends into the annular groove (121) and is sealed with the sealing element (122).

12. The spray freeze-drying system according to any one of claims 1 to 6, characterized in that, The vacuum freeze-drying apparatus also includes: Vacuum pump (31); The cold trap (32) has a cooling chamber, the outlet of which is connected to the vacuum pump (31), and the inlet of which is connected to the freeze-drying chamber; A compressor (33) is used to supply cooling medium to the cooling coils of the freeze-drying chamber (21) and the cooling coils of the cold trap (32).

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