Mupirocin ointment preparation device capable of accurately controlling temperature and slowly cooling

Abstract

The invention discloses a mupirocin ointment preparation device capable of accurately controlling temperature and slowly cooling, and relates to the technical field of ointment preparation. According to the scheme, the reaction kettle comprises a tank body with a jacket and further comprises a stirrer and a shaft body rotationally connected with the tank body, one end of the shaft body extends into the tank body, and a cooling flow channel is formed in the shaft body; the plurality of stirring blade units are distributed along the axial direction of the stirring shaft and are communicated with the cooling flow channel, and a cavity for a cooling medium to circulate is formed in each stirring blade unit; and the partition flow adjusting mechanism is arranged in the shaft body and is used for independently controlling on-off or flow of the cooling medium flowing to each stirring blade unit. Independent cooling loops are integrated in the stirring shaft and the blades, so that an internal cooling mode of directly exchanging heat from the inside of a material is realized, and an internal and external synergistic three-dimensional cooling network is formed by combining the internal cooling mode with external cooling of the jacket.

Description

Technical Field

[0001] This invention relates to the field of ointment preparation technology, and in particular to a mupirocin ointment preparation device with precise temperature control and slow cooling. Background Technology

[0002] As a topical antibiotic preparation, the physical stability and uniformity of mupirocin ointment directly affect its efficacy and user experience. During the preparation process, the semi-finished product after high-temperature mixing needs to undergo a slow and uniform cooling process to promote the formation of a stable eutectic structure between the active pharmaceutical ingredient and the matrix, and to prevent oil precipitation or demulsification.

[0003] Existing preparation equipment typically uses jacketed stirred tanks for cooling, which is a relatively crude cooling method. It mainly relies on the cooling medium circulating inside the jacket for heat exchange, and the cooling rate of the material inside the tank is roughly adjusted by controlling the overall temperature or flow rate of the cooling medium. However, this traditional method has obvious limitations: First, cooling proceeds from the tank wall inward, which can easily lead to the material near the tank wall being undercooled, while the temperature of the material in the central area remains higher, resulting in a significant temperature gradient inside the tank. Second, as the material temperature decreases and the viscosity increases, its internal heat conduction efficiency decreases, and the above-mentioned temperature non-uniformity will be further aggravated. This non-uniform cooling environment may lead to local phase transition differences, resulting in poor uniformity of the final product and difficulty in ensuring batch-to-batch stability. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to solve the above-mentioned problems.

[0005] To achieve the above-mentioned technical objectives, the present invention provides a mupirocin ointment preparation device with precise temperature control and slow cooling: It includes a jacketed tank, and also includes: A stirrer with a shaft rotatably connected to the tank, one end of which extends into the tank, and a cooling channel is provided inside the shaft. Multiple stirring blade units are distributed along the stirring shaft and communicate with the cooling channel. Each stirring blade unit has a cavity for the flow of cooling medium. A zoned flow regulation mechanism, located within the shaft body, is used to independently control the on / off state or flow rate of the cooling medium flowing to each of the stirring blade units.

[0006] Preferably, the shaft includes a main shaft rotatably connected to the tank and a stirring shaft fixed to the bottom of the main shaft and disposed inside the tank.

[0007] Preferably, the zoned flow regulation mechanism includes at least one axially movable valve bar, on which an adjustment groove is provided; the stirring shaft is provided with a flow channel opening communicating with each of the stirring blade units; by moving the valve bar, the adjustment groove is selectively aligned or misaligned with the flow channel opening corresponding to different stirring blade units.

[0008] Preferably, the valve strip is driven by an adjustment drive assembly, which includes an adjustment motor disposed in the main shaft and an adjustment gear driven therefrom, and the surface of the valve strip is provided with tooth grooves that mesh with the adjustment gear.

[0009] Preferably, there are two valve strips, and the two valve strips control the flow of cooling medium in different stirring blade units.

[0010] Preferably, the stirring blade unit includes a flow guide sleeve and hollow blades connected to both sides thereon. The flow guide sleeve has a flow guide channel inside and a through hole on its outer wall that connects the cooling channel inside the stirring shaft with the inner cavity of the hollow blade.

[0011] Preferably, the hollow blade has a meandering guide plate inside.

[0012] Preferably, a rotary joint is connected to the top end of the spindle, the rotary joint including a diverter sleeve fixed to the spindle and a rotating sealing sleeve connected to an external pipeline.

[0013] Preferably, the cooling channel inside the shaft is divided into two isolated inflow channels and outflow channels by a baffle extending along the axial direction. The inflow channels and outflow channels are connected to the external cooling pipeline through the inlet and outlet nozzles, respectively.

[0014] Preferably, a spiral guide vane is provided inside the jacket of the tank.

[0015] As can be seen from the above technical solutions, this application has the following beneficial effects: 1. By integrating independent cooling circuits inside the stirring shaft and hollow blades, an internal cooling method that directly exchanges heat from the inside of the material is realized. Combined with the external cooling of the jacket, a three-dimensional cooling network with internal and external coordination is formed. This effectively breaks the temperature gradient that exists when relying solely on jacket cooling in the traditional way, and significantly reduces the temperature difference between the core area of ​​the material inside the tank and the tank wall area, providing a physical basis for achieving precise and uniform slow cooling. 2. By setting up a zoned flow regulation mechanism, the cooling on / off of the stirring blade unit at different axial heights can be independently controlled by the movement of the valve bar. This allows the device to enhance the cooling of high-temperature areas or weaken the cooling of low-temperature areas based on real-time temperature feedback, thus achieving dynamic and targeted distribution of cooling power in three-dimensional space, thereby actively suppressing and eliminating local temperature differences. 3. The valve bar, regulating motor, etc. are integrated inside the rotating main shaft. The fluid transmission problem under dynamic sealing is solved by the rotary joint. This avoids setting a large number of complex valves and pipelines on the outside of the tank, making the overall structure more compact, reducing the risk of external leakage, and improving the reliability and sealing of the system in long-term operation. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0017] Figure 1 A schematic diagram of the overall structure of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 2 A cross-sectional schematic diagram of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 3 A partial cross-sectional view of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 4 A schematic cross-sectional view of the diversion sleeve of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 5 A schematic diagram of the overall structure of the diversion sleeve of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 6 A schematic diagram of the exploded structure of the stirrer in a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention. Figure 7 A schematic diagram of the overall structure of the adjustment drive component of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 8 A cross-sectional view of the stirring blade unit of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention. Figure 9 A schematic cross-sectional view of the flow guide sleeve of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention; Figure 10 A cross-sectional view of the stirring shaft of a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention. Figure 11This is a schematic diagram of the overall structure of the valve strip in a mupirocin ointment preparation device with precise temperature control and slow cooling provided by the present invention. Attached image description: 10. Tank body; 11. First inlet flange; 12. First outlet flange; 13. Second inlet flange; 14. Second outlet flange; 15. Guide vane; 20. Agitator motor; 21. Drive gear; 22. Driven gear; 30. Agitator; 31. Main shaft; 32. Agitator shaft; 321. Slide groove; 33. Agitator blade unit; 331. Guide sleeve; 3311. Through hole; 3312. Guide channel; 332. Hollow blade; 3321. Guide plate; 34. Divider sleeve; 35. Rotary sealing sleeve; 351. Feed nozzle; 352. Discharge nozzle; 36. Valve strip; 361. Gear groove; 362. Adjusting through groove; 37. Adjusting drive assembly; 371. Sealing seat; 372. Adjusting motor; 373. Adjusting gear. Detailed Implementation

[0019] The following description is exemplary in nature and is not intended to limit the scope, application, or use of this disclosure. It should be understood that in all these figures, the same or similar reference numerals indicate the same or similar parts and features. The figures are merely schematic representations of the concept and principles of embodiments of this disclosure and do not necessarily show the specific dimensions and scale of the various embodiments of this disclosure. Certain details or structures of embodiments of this disclosure may be exaggerated in particular portions of certain figures.

[0020] Example 1, see Figures 1-11 As shown, a mupirocin ointment preparation device with precise temperature control and slow cooling includes a main container, which is a tank 10 with a jacket structure. The jacket is provided with spiral guide vanes 15 to extend the flow path of the cooling medium in the jacket and increase the heat exchange time. The surface of the tank body 10 is fixed with a first feed flange 11, a first discharge flange 12, a second feed flange 13, and a second discharge flange 14. The first feed flange 11 and the first discharge flange 12 are located at the upper and lower ends of the tank body 10, respectively, and are connected to the inner cavity of the tank body 10. They are used for feeding the mupirocin ointment to be cooled and discharging the mupirocin ointment after cooling, respectively. The second feed flange 13 and the second discharge flange 14 are distributed vertically and are connected to the internal space of the jacket. They are used for introducing and discharging the cooling medium, respectively. In the actual preparation process, the mupirocin ointment to be cooled enters the inner cavity of the tank body 10 through the first feed flange 11. At the same time, the cooling medium provided by the external cooling unit, such as a low-temperature ethylene glycol aqueous solution, enters the jacket from the second feed flange 13. Under the guidance of the guide vane 15, it flows spirally and fully exchanges heat with the tank wall before being discharged from the second discharge flange 14. This cycle is repeated to achieve cooling of the material in the tank.

[0021] Furthermore, to achieve uniform heat exchange of the material and avoid localized overcooling of the material on the inner wall of the tank 10, a stirring mechanism is also included. The stirring mechanism includes a stirring motor 20 and a stirrer 30 linked to the stirring motor 20. The stirring motor 20 is fixed to the top of the tank 10, and the output shaft of the stirring motor 20 is fixed with a drive gear 21, which meshes with a driven gear 22, i.e., the stirrer 30. The stirring motor 20 drives the stirrer 30 to rotate, causing convection in the mupirocin ointment to be cooled inside the tank, effectively avoiding uneven temperature caused by localized overcooling or overheating, and laying the foundation for precise control of the overall temperature.

[0022] To further ensure uniform cooling both inside and outside, the stirring mechanism not only performs the stirring function but also constitutes an independent internal cooling circuit. Specifically, the stirrer 30 includes a main shaft 31 and a stirring shaft 32. The main shaft 31 is rotatably and sealed to the top of the tank 10 via bearings. The stirring shaft 32 is fixed to the bottom of the main shaft 31 and extends into the tank 10. The interiors of both the main shaft 31 and the stirring shaft 32 are separated into two independent and parallel cooling channels by axially extending baffles, such as an inflow channel and a... The main shaft 31 and the corresponding flow channels in the stirring shaft 32 are interconnected. In order to reliably connect the stationary cooling pipe with the flow channel in the rotating main shaft 31, a flow divider sleeve 34 is fixed at the top of the main shaft 31. The flow divider sleeve 34 is cylindrical and a semi-circular baffle is fixed at its bottom. A rotary sealing sleeve 35 is fitted on the outer surface of the flow divider sleeve 34 and rotates to seal it. At the same time, the rotary sealing sleeve 35 and the top of the main shaft 31 are also connected by a rotary seal (such as a mechanical seal) to achieve a rotary seal connection. See Figure 4 As shown, this structure creates an arc-shaped channel between the outer wall of the diversion sleeve 34 and the inner wall of the rotating sealing sleeve 35, as illustrated in the attached diagram. Figure 4 The L1 mark is in the middle, while the interior of the diversion sleeve 34 independently forms another channel, as shown in the attached diagram. Figure 4 The L2 mark indicates that two independent flow channels inside the main shaft 31 are connected to channels L1 and L2 respectively. The side of the rotating sealing sleeve 35 is fixed with a feed nozzle 351 connected to channel L1, and the top of the sleeve has a discharge nozzle 352 connected to channel L2. Through this rotary sealing structure, fluid transmission between the stationary pipeline and the flow channel inside the rotating shaft is realized without affecting the normal rotation of the main shaft 31. In actual operation, the cooling medium can enter from the feed nozzle 351, flow through channel L1, the main shaft 31 and the inflow channel of the stirring shaft 32, and after completing the heat exchange, it returns from the outflow channel of the stirring shaft 32 and is discharged from the discharge nozzle 352 through channel L2, forming an internal cooling circuit parallel to the jacket cooling. This internal cooling acts on the internal area of ​​the material and forms a common heat exchange with the external jacket cooling, improving the uniformity of the heat exchange temperature field.

[0023] To further refine the cooling process to the spatial dimension, several stirring blade units 33 are axially distributed and fixed on the outer surface of the stirring shaft 32. This embodiment uses four units as an example. Each stirring blade unit 33 includes a guide sleeve 331 sealed and fixed on the stirring shaft 32, and hollow blades 332 symmetrically fixed on both sides of the guide sleeve 331. The interior of the hollow blades 332 is a hollow cavity, and a meandering guide plate 3321 is fixed inside, dividing the inner cavity of the hollow blades 332 into a serpentine flow channel. Two through holes 3311 are symmetrically opened on the outer surface of the guide sleeve 331, and a guide channel 3312 with both ends through is opened inside. A flow channel is provided on the surface corresponding to the through hole 3311 of each guide sleeve 331. Through this structure, the cooling medium flowing into the stirring shaft 32 must enter the cavity of the hollow blade 332 on the same side through the through hole 3311 on one side, flow to the guide channel 3312 of the guide sleeve 331 under the guidance of the guide plate 3321, and then enter the cavity of the hollow blade 332 on the other side. Finally, it flows back to the outlet channel of the stirring shaft 32 through the through hole 3311 on the other side. The purpose is to force the cooling medium to flow through the entire cavity of each hollow blade 332, ensuring the absolute uniformity of cooling of the hollow blades 332 at the same level and avoiding the problem of uneven flow distribution in parallel flow paths.

[0024] To achieve further precision and dynamic adjustability of cooling, a valve strip 36 and an adjustment drive assembly 37 are provided, which can independently control the cooling on and off of each stirring blade unit 33. A sliding groove 321 is provided axially on the inner wall of the main shaft 31 and the stirring shaft 32. The valve strip 36 is slidably and sealingly connected in the sliding groove 321, and its length covers multiple stirring blade units 33. The surface of the valve strip 36 corresponds to the position of the two through holes 3311 of each guide sleeve 331, and an adjustment groove 362 is provided through it. The adjustment drive assembly 37 is fixed to the top of the main shaft 31. It includes a sealing seat 371 that is sealed and fixed to the main shaft 31, a micro adjustment motor 372 installed in the sealing seat 371, and an adjustment gear 373 fixed on the output shaft of the adjustment motor 372. The outer surface of the valve strip 36 is provided with a toothed groove 361 that meshes with the adjustment gear 373. By driving the adjustment gear 373 in forward and reverse rotation of the adjustment motor 372, the lifting position of the valve strip 36 in the sliding groove 321 can be precisely controlled. It is worth mentioning that the position and number of the adjusting grooves 362 on the valve strip 36 are designed according to the number of temperature layers to be controlled, and are not specifically limited here. The control logic is as follows: by raising and lowering the valve strip 36, the alignment relationship between the adjusting grooves 362, the through holes on the stirring shaft 32, and the through holes 3311 on the guide sleeve 331 is changed. When the three are perfectly aligned, the cooling channels of the hollow blades 332 in that layer are fully open; when the valve strip 36 moves and causes the adjusting grooves 362 to misalign, the channels are completely or partially closed. This is achieved by independently controlling multiple valve strips 36. The position allows for independent, stepless adjustment of the cooling intensity of the hollow blades 332 at different levels. For example, if the temperature of the material in the upper part of the tank 10 is detected to be too high, the valve strip 36 of the corresponding upper hollow blade 332 can be controlled to open the cooling channel of that layer, increasing the cooling intensity of that area. Conversely, if the temperature of the lower material is close to the lower limit, the cooling of the lower layer can be reduced or turned off. This structure realizes the targeted delivery of cooling power in three-dimensional space. The specific control algorithm that cooperates with the mechanical structure of this embodiment is set by those skilled in the art according to specific needs, and will not be described in detail here.

[0025] Specifically, taking the four sets of stirring blade units 33 in this embodiment as an example, the stirring shaft 32 has eight holes in two rows from bottom to top corresponding to the through holes 3311, with four holes in each row, labeled K1, K2, K3, and K4. If all of them are controlled by a single valve strip 36, then the combination of the four holes needs to be considered, resulting in a complex structure and a large control lifting span. In this embodiment, there are two valve strips 36, and the two valve strips 36 are distributed opposite to each other. The first valve strip 36 controls K1 and K2 in the first row, and the second valve strip 36 controls K3 and K4 in the second row. That is, the initial position is when K1 and K2 both coincide with and are connected to the through holes 3311. When the first valve strip 36 rises by one unit height, which is equal to the opening diameter of the through hole 3311, K1 and the through hole 3311 are connected, and K2 is blocked. When it descends by one unit height from the initial position, K1 is blocked, and K2 and the through hole 3311 are connected. The height of the adjusting through groove 362 opened by the first valve strip 36 corresponding to the positions of K3 and K4 spans four units. That is, the rise and fall of the first valve strip 36 does not affect the opening and closing of K3 and K4. K3 and K4 are controlled by the second valve strip 36, and the control logic is the same as that of the first valve strip 36. In this way, all combinations of the four holes can be easily realized.

[0026] It is worth mentioning that, in order to ensure the power supply of the regulating motor 372 on the rotating spindle 31, its power supply wire is buried inside the spindle 31 and connected to the external power supply through a conductive slip ring installed on the spindle 31. This ensures the reliability of power transmission and does not affect the normal operation of the spindle 31.

[0027] The exemplary implementation of the solution proposed in this disclosure has been described in detail above with reference to preferred embodiments. However, those skilled in the art will understand that various modifications and alterations can be made to the above specific embodiments without departing from the spirit of this disclosure, and various combinations can be made to the various technical features and structures proposed in this disclosure without exceeding the protection scope of this disclosure, which is determined by the appended claims.

Claims

1. A mupirocin ointment preparation device with precise temperature control and slow cooling, comprising a jacketed container (10), characterized in that, Also includes: A stirrer (30) has a shaft that is rotatably connected to the tank (10), with one end of the shaft extending into the tank (10), and a cooling channel provided inside the shaft. Multiple stirring blade units (33) are axially distributed along the stirring shaft (32) and connected to the cooling channel. The stirring blade unit (33) has a cavity for the flow of cooling medium. A zoned flow regulation mechanism is installed in the shaft body to independently control the on / off state or flow rate of the cooling medium flowing to each of the stirring blade units (33).

2. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 1, characterized in that, The shaft includes a main shaft (31) rotatably connected to the tank (10) and a stirring shaft (32) fixed to the bottom of the main shaft (31) and located inside the tank (10).

3. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 2, characterized in that, The zoned flow regulation mechanism includes at least one axially movable valve strip (36), on which an adjustment groove (362) is provided; the stirring shaft (32) is provided with a flow channel opening that communicates with each of the stirring blade units (33); by moving the valve strip (36), the adjustment groove (362) is selectively aligned or misaligned with the flow channel opening corresponding to different stirring blade units (33).

4. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 3, characterized in that, The valve strip (36) is driven by an adjustment drive assembly (37), which includes an adjustment motor (372) disposed in the main shaft (31) and an adjustment gear (373) driven therefrom. The surface of the valve strip (36) is provided with a tooth groove (361) that meshes with the adjustment gear (373).

5. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 3, characterized in that, The number of valve strips (36) is two, and the two valve strips (36) respectively control the on / off of the cooling medium of different stirring blade units (33).

6. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 1, characterized in that, The stirring blade unit (33) includes a flow guide sleeve (331) and hollow blades (332) connected to its two sides. The flow guide sleeve (331) has a flow guide channel (3312) inside and a through hole (3311) on its outer wall to connect the cooling channel inside the stirring shaft (32) with the inner cavity of the hollow blade (332).

7. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 6, characterized in that, The hollow blade (332) has a meandering guide plate (3321) inside.

8. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 2, characterized in that, The top end of the main shaft (31) is connected to a rotary joint, which includes a diversion sleeve (34) fixed to the main shaft (31) and a rotating sealing sleeve (35) connected to an external pipeline.

9. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 1, characterized in that, The cooling channel inside the shaft is divided into two isolated inflow channels and outflow channels by a baffle extending along the axial direction. The inflow channels and outflow channels are connected to the external cooling pipeline through the inlet (351) and outlet (352) respectively.

10. The mupirocin ointment preparation apparatus with precise temperature control and slow cooling according to claim 1, characterized in that, The jacket of the tank (10) is provided with a spiral guide vane (15).

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