Synthetic methods for two methanesulfonylphenyl oxadiazole active esters
By synthesizing a novel methanesulfonylphenyloxadiazole active ester, the problem of the single structure of existing compounds has been solved, achieving stable drug linkage and improved economic benefits, and it is suitable for applications such as antibodies, peptides and hydrogels.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WUHAN AOFEI TECH CO LTD
- Filing Date
- 2024-11-25
- Publication Date
- 2026-05-26
AI Technical Summary
The existing methanesulfonylphenyloxadiazole compounds have relatively simple side chain structures, which are difficult to meet the growing market demand. Furthermore, the reaction between maleimide and thiol group is prone to producing diastereomers and reverse Michael addition reactions, resulting in unstable drug linkage.
Using inexpensive commercial raw materials, two novel methanesulfonyl phenyl oxadiazole active esters were synthesized through conventional transformations such as condensation and coupling. The side chains are characterized by alkyl hydrophobic chains, forming a complementary structure to the hydrophilic chain of polyethylene glycol.
The preparation method is simple, the raw materials are readily available, and the product has high added value. It is applicable to fields such as antibodies, peptides, and hydrogels, and improves the stability and economic benefits of the products.
Smart Images
Figure CN122079974A_ABST