An intraocular pressure measurement calibration device and calibration method

Abstract

The present application relates to the technical field of medical devices, and more particularly to an intraocular pressure measurement calibration device and calibration method, the intraocular pressure measurement calibration device comprising a lifting focusing mechanism, an overall rotating mechanism and an angle adjusting mechanism; wherein one end of the lifting focusing mechanism is connected with a shooting unit, and the other end is connected with the angle adjusting mechanism; the angle adjusting mechanism is engaged with the overall rotating mechanism. Through the cooperation of the mechanisms, the present application realizes the precise calibration of focal length, direction and angle, greatly reduces the operation difficulty, and can adapt to the clinical application scenarios of implantable intraocular pressure monitoring systems; through the step-by-step calibration of image definition optimization, stripe posture correction and incident light axis alignment, the present application effectively solves the problems of poor interference stripe quality and difficulty in demodulation in the prior art, and significantly improves the accuracy and data consistency of intraocular pressure measurement; the device structure is compact and has strong compatibility, and can be used with existing implantable intraocular pressure sensors and image processing systems, and has good clinical promotion value.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an intraocular pressure measurement and calibration device and calibration method. Background Technology

[0002] Glaucoma is one of the leading causes of blindness in humans, and high intraocular pressure is a core risk factor for its development, serving as a key indicator for clinical diagnosis, treatment goal setting, and prognostic assessment. Currently, intraocular pressure measurement technologies are mainly divided into two categories: traditional contact and non-contact tonometer measurements and implantable intraocular pressure monitoring. Among them, implantable intraocular pressure monitoring systems have become a key focus of clinical research and application due to their ability to provide continuous, 24 / 7 intraocular pressure monitoring.

[0003] Existing implantable intraocular pressure measurement technology based on the principle of Fabry-Perot microcavity optical interference utilizes the principle that changes in intraocular pressure cause micro-deformation of the sensitive membrane of the implanted FP microcavity, thereby altering the cavity length and interference spectrum characteristics. Then, by using an external imaging module in conjunction with a mobile phone to capture, identify, and demodulate the interference fringe pattern, non-invasive, portable, and real-time intraocular pressure detection can be achieved.

[0004] However, the focus adjustment of such systems relies on manual operation. Operators need to adjust the axial distance between the imaging module and the sensor based on their experience. This is not only cumbersome to operate, but also makes it difficult to accurately obtain interference fringe images with the best clarity, resulting in large errors in subsequent intraocular pressure calculation. Summary of the Invention

[0005] To address the problem of accurately acquiring interference fringe images during intraocular pressure measurement in existing technologies, this invention provides an intraocular pressure measurement calibration device. This device, through the cooperation of various adjustment structures, enables multi-dimensional adjustment of the imaging element, thus solving the problem of accurately acquiring interference fringe images during intraocular pressure measurement in existing technologies.

[0006] The technical solution adopted by this invention to solve its technical problem is: An intraocular pressure measurement and calibration device includes a lifting and focusing mechanism, an overall rotation mechanism, and an angle adjustment mechanism; wherein, one end of the lifting and focusing mechanism is connected to the imaging unit, and the other end is connected to the angle adjustment mechanism; the angle adjustment mechanism is engaged with the overall rotation mechanism.

[0007] Optionally, the overall rotating mechanism includes a rotating bracket, a rotating drive motor, and an arc-shaped rack and pinion guide rail; the output shaft of the rotating drive motor is coaxially connected to the rotating bracket via a coupling; the rotating bracket is fixedly connected to the arc-shaped rack and pinion guide rail; and the overall rotating mechanism is meshed with the angle adjustment mechanism via the arc-shaped rack and pinion guide rail.

[0008] Optionally, the angle adjustment mechanism includes a connecting plate, an angle adjustment motor, and a gear; the output shaft of the angle adjustment motor is coaxially connected to the center hole of the gear; the gear is fixedly connected to the connecting plate; the angle adjustment mechanism is connected to the lifting and focusing mechanism through the connecting plate; and the angle adjustment mechanism is meshed with the overall rotating mechanism through the gear.

[0009] Optionally, the angle adjustment mechanism further includes a plurality of rollers; the angle adjustment mechanism is tactilely connected to the overall rotating mechanism through the plurality of rollers; the number of rollers is even.

[0010] Optionally, the number of rollers is four.

[0011] Optionally, the lifting and focusing mechanism includes a lifting drive motor, a support ear, and a screw shaft; one end of the screw shaft is connected to the support ear via a bearing, and the other end is connected to the shooting unit; the lifting and focusing mechanism is connected to the angle adjustment mechanism via the support ear; the output shaft of the lifting drive motor is coaxially connected to the screw shaft via a coupling.

[0012] Optionally, the lifting and focusing mechanism further includes an anti-rotation sleeve and a guide post; the screw shaft is provided with an external thread, the anti-rotation sleeve is provided with a through hole, and the through hole is provided with an internal thread adapted to the external thread; the screw shaft and the anti-rotation sleeve are connected by the external thread and the internal thread to form a screw-nut transmission pair; one end of the guide post is fixedly connected to the support lug, and the other end is inserted into the anti-rotation sleeve.

[0013] Optionally, the number of guide posts is two.

[0014] Optionally, it also includes a self-calibration unit; the lifting and focusing mechanism, the overall rotation mechanism, and the angle adjustment mechanism are all communicatively connected to the self-calibration unit.

[0015] Another object of the present invention is to provide an intraocular pressure measurement calibration method, wherein intraocular pressure measurement calibration is performed using the intraocular pressure measurement calibration device described above; The intraocular pressure measurement calibration method includes the following steps: Obtain the original interference fringe image; The original interference fringe image is preprocessed to obtain the effective imaging area; The optimal focus position is determined and located based on the sharpness of multiple frames of images at different focal lengths. Calculate the deflection angle of the interference fringes and output a rotation command to complete the coarse attitude calibration. Based on the convolutional neural network to identify the incident angle, hierarchical micro-angle closed-loop correction is performed according to the incident angle to correct the incident light to near 0° vertical incidence, and the calibration is completed.

[0016] The beneficial effects of this invention are: The intraocular pressure measurement calibration device provided by this invention achieves precise calibration of focal length, direction, and angle through mechanism collaboration, significantly reducing the difficulty of operation and adapting to the clinical application scenarios of implantable intraocular pressure monitoring systems. Through stepwise calibration of image clarity optimization, fringe posture correction, and incident optical axis alignment, it effectively solves the problems of poor interference fringe quality and difficulty in demodulation in existing technologies, significantly improving the accuracy and data consistency of intraocular pressure measurement. The device has a compact structure, strong compatibility, and can be used in conjunction with existing implantable intraocular pressure sensors and image processing systems, and has good clinical promotion value. Attached Figure Description

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0018] Figure 1 The structure of the intraocular pressure measurement and calibration device in this invention is simplified. Figure 1 ; Figure 2 The structure of the intraocular pressure measurement and calibration device in this invention is simplified. Figure 2 ; Figure 3 This is a simplified structural diagram of the overall rotating mechanism in this invention; Figure 4 This is an exploded view of the overall rotating mechanism in this invention; Figure 5 This is a simplified structural diagram of the angle adjustment mechanism in this invention; Figure 6 This is a simplified structural diagram of the lifting and focusing mechanism in this invention; Figure 7 This is an exploded view of the lifting and focusing mechanism in this invention; Figure 8 This is a flowchart illustrating the intraocular pressure measurement and calibration method of the present invention.

[0019] In the diagram: 1-Lifting and focusing mechanism; 11-Lifting drive motor; 12-Support ear; 13-Screw shaft; 14-Anti-rotation sleeve; 141-Through hole; 15-Guide column; 2-Integral rotation mechanism; 21-Rotating bracket; 22-Rotating drive motor; 23-Arc-shaped rack and pinion guide rail; 3-Angle adjustment mechanism; 31-Connecting plate; 32-Angle adjustment motor; 33-Gear; 34-Roller; 4-Shooting unit; 41-Shooting element; 42-External shooting module; 43-Shooting bracket. Detailed Implementation

[0020] The present invention will now be described in further detail. The embodiments described below are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0021] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0022] To address the problem of accurately acquiring interference fringe images during intraocular pressure measurement in existing technologies, this invention provides an intraocular pressure measurement calibration device, see [link to relevant documentation]. Figure 1 , Figure 2 As shown, the intraocular pressure measurement calibration device includes a lifting and focusing mechanism 1, an overall rotation mechanism 2, and an angle adjustment mechanism 3; wherein, one end of the lifting and focusing mechanism 1 is connected to the imaging unit 4, and the other end is connected to the angle adjustment mechanism 3; the angle adjustment mechanism 3 is engaged with the overall rotation mechanism 2.

[0023] The imaging unit 4 in this invention can be selected from the corresponding existing technology; specifically, the imaging unit 4 of this invention preferably includes an imaging element 41 and an external imaging module 42, and more preferably the external imaging module 42 includes a housing, an optical path component disposed inside the housing, and a light source disposed outside the housing; the housing is provided with an imaging hole; the light emitted by the light source is transmitted to the Fabry-Perot microcavity after passing through the optical path component, and generates an interference pattern; the imaging element 41 includes a lens; the imaging hole of the external imaging module 42 is adapted to cooperate with the lens of the imaging element 41 so as to obtain the interference pattern through the imaging element 41.

[0024] During operation, the light emitted by the light source of the external imaging module 42 passes through the optical path assembly and is perpendicularly incident on the Fabry-Perot microcavity (FP resonant cavity) of the intraocular pressure sensor. Upon entering the cavity of the Fabry-Perot microcavity, the light is reflected by multiple surfaces and interferes to obtain an interference pattern. The obtained interference pattern is then transmitted to the lens of the imaging element 41 through the optical path assembly. The interference pattern can be captured in real time by taking a picture through the imaging element 41, and the real-time intraocular pressure can be obtained based on the real-time captured interference pattern.

[0025] The lifting and focusing mechanism 1 in this invention is the basic support base of the entire adjustment system. Its top end is connected to the angle adjustment mechanism 3, and its bottom end is connected to the shooting unit 4. Specifically, its bottom end is preferably fixedly connected to the shooting bracket 43 used to clamp the shooting unit 4, forming a vertical focusing drive unit. The meshing angle adjustment mechanism 3 and the overall rotation mechanism 2 realize coordinated position adjustment in the horizontal circumferential and pitch angle dimensions. During operation, the lifting and focusing mechanism 1 realizes automatic adjustment of the imaging focal length, the overall rotation mechanism 2 completes coarse correction of the interference fringe attitude, and the angle adjustment mechanism 3 realizes precise alignment of the incident light micro-angle. Through the three forming a three-level coordinated calibration system, the accurate acquisition of interference fringe images can be achieved, effectively improving the measurement accuracy.

[0026] The intraocular pressure measurement calibration device provided by this invention achieves precise calibration of focal length, direction, and angle through mechanism collaboration, significantly reducing the difficulty of operation and adapting to the clinical application scenarios of implantable intraocular pressure monitoring systems. Through stepwise calibration of image clarity optimization, fringe posture correction, and incident optical axis alignment, it effectively solves the problems of poor interference fringe quality and difficulty in demodulation in existing technologies, significantly improving the accuracy and data consistency of intraocular pressure measurement. The device has a compact structure, strong compatibility, and can be used in conjunction with existing implantable intraocular pressure sensors and image processing systems, and has good clinical promotion value.

[0027] See Figure 3 , Figure 4 As shown, the preferred integral rotating mechanism 2 of the present invention includes a rotating bracket 21, a rotating drive motor 22, and an arc-shaped rack and pinion guide rail 23; wherein, the output shaft of the rotating drive motor 22 is coaxially connected to the rotating bracket 21 via a coupling; the rotating bracket 21 is fixedly connected to the arc-shaped rack and pinion guide rail 23; the integral rotating mechanism 2 is meshed with the angle adjustment mechanism 3 via the arc-shaped rack and pinion guide rail 23.

[0028] Specifically, the rotary drive motor 22 is fixedly mounted on the top of the overall rotating mechanism 2, and its output shaft is coaxially connected to the rotating bracket 21 via a coupling, driving the rotating bracket 21 to perform circumferential rotation. The rotating bracket 21 is fastened to the upper end face of the arc-shaped rack and pinion guide 23 by two parallel cylindrical pins, ensuring synchronous transmission of rotational motion without relative slippage. When the rotary drive motor 22 drives the rotating bracket 21 to rotate, it causes the entire device to rotate circumferentially around the motor output shaft, achieving coarse positioning of the initial attitude of the interference fringe image, so that the subsequent angle adjustment mechanism 3 only needs to make fine adjustments in a single direction to complete the precise angle correction.

[0029] The present invention preferably uses an arc-shaped rack and pinion guide 23 as an arc-shaped rack and pinion structure, with the center of the arc coinciding with the center of the optical axis of the device, to ensure that the optical axis position remains unchanged during overall rotation and adjustment, and to prevent eccentricity error.

[0030] See Figure 5 As shown, the preferred angle adjustment mechanism 3 of the present invention includes a connecting plate 31, an angle adjustment motor 32, and a gear 33; the output shaft of the angle adjustment motor 32 is coaxially connected to the center hole of the gear 33; the gear 32 is fixedly connected to the connecting plate 31; the angle adjustment mechanism 3 is connected to the lifting and focusing mechanism 1 through the connecting plate 31; the angle adjustment mechanism 3 is meshed with the overall rotating mechanism 2 through the gear 33.

[0031] Specifically, gear 33 meshes with the arc-shaped rack guide rail 23 in the overall rotating mechanism 2. Preferably, gear 33 is a spur gear, whose tooth profile matches the rack surface of the arc-shaped rack guide rail 23, forming a stable meshing transmission pair. The output shaft of the angle adjustment motor 32 is coaxially connected to the center hole of gear 33. The angle adjustment motor 32 drives gear 33 to rotate, causing gear 33 to mesh and roll along the arc-shaped rack guide rail 23, thereby driving the connecting disk 31 and the upper mechanism to achieve micro-angle pitch adjustment around the arc center. This mechanism can perform high-precision correction of the deflection attitude of the optical imaging module, ensuring that the incident light is incident at a near 0° vertical angle onto the surface of the sensor FP microcavity sensitive diaphragm, strictly meeting the extremely high requirements of the Fabry-Perot interferometer for the incident angle, and significantly improving the imaging quality of the interference fringes.

[0032] Furthermore, the preferred angle adjustment mechanism 3 of the present invention further includes a plurality of rollers 34; the angle adjustment mechanism 3 is tactilely connected to the overall rotating mechanism 2 through the plurality of rollers 34; the number of rollers 34 is even; more preferably, the number of rollers 34 is four.

[0033] The present invention preferably uses cylindrical guide rollers as rollers. The four rollers 34 are coaxially fixed to the four corners of the connecting plate 31 by cylindrical pins and are symmetrically arranged on the left and right sides of the arc-shaped rack and pinion guide rail 23. The outer wall of the roller 34 forms a rolling fit with the side of the guide rail and can slide freely along the arc surface of the guide rail to achieve stable guidance and support.

[0034] See Figure 6 , Figure 7 As shown, the preferred lifting and focusing mechanism 1 of the present invention includes a lifting drive motor 11, a support ear 12, and a screw shaft 13; one end of the screw shaft 13 is connected to the support ear 12 through a bearing, and the other end is connected to the shooting unit 4; the lifting and focusing mechanism 1 is connected to the angle adjustment mechanism 3 through the support ear 12; the output shaft of the lifting drive motor 11 is coaxially connected to the screw shaft 13 through a coupling.

[0035] Furthermore, the preferred lifting and focusing mechanism 1 of the present invention further includes an anti-rotation sleeve 14 and a guide post 15; the screw shaft 13 is provided with an external thread, the anti-rotation sleeve 14 is provided with a through hole 141, and the through hole 141 is provided with an internal thread adapted to the external thread; the screw shaft 13 and the anti-rotation sleeve 14 are engaged by the external thread and the internal thread to form a screw-nut transmission pair; one end of the guide post 15 is fixedly connected to the support ear 12, and the other end is inserted into the anti-rotation sleeve 14.

[0036] The present invention further preferably has two guide posts 15.

[0037] Specifically, the lifting drive motor 11 is fixedly mounted on the top of the lifting and focusing mechanism 1, and its output shaft is coaxially connected to the screw shaft 13 via a coupling to drive the screw shaft 13 to rotate. The upper end of the screw shaft 13 is fitted into the inner ring of the bearing, and the bearing is press-fitted into the center mounting hole of the support ear 12, providing radial positioning and rotational support for the screw shaft 13. The anti-rotation sleeve 14 has an internal thread, forming a screw-nut transmission pair with the screw shaft 13. The anti-rotation sleeve 14 has symmetrically arranged circular guide holes on its left and right sides, and guide posts 15 are symmetrically arranged on both sides of the screw shaft 13 and fixedly connected to the support ear 12. The guide posts 15 are clearance-fitted into the guide holes and can slide smoothly up and down along the hole wall, providing circumferential anti-rotation and linear guidance for the anti-rotation sleeve 14. When the lifting drive motor 11 drives the screw shaft 13 to rotate, the anti-rotation sleeve 14 moves axially up and down along the screw shaft 13, causing the shooting bracket 43 and the shooting unit 4 to move synchronously, thereby accurately adjusting the imaging focal length, optimizing the autofocus effect of the interference fringe image, and ensuring image clarity and integrity.

[0038] In summary, in the intraocular pressure measurement and calibration device provided by the present invention, the lifting and focusing mechanism 11, the overall rotation mechanism 2, and the angle adjustment mechanism 3 form a hierarchical layout architecture of "base-coarse adjustment-fine adjustment". Specifically, the lifting and focusing mechanism 1 serves as the basic support base of the entire adjustment system. Its top end is fixedly connected to the connecting plate 31 of the angle adjustment mechanism 3 through the support ear 12, and its bottom end is fixedly connected to the shooting bracket 43 used to clamp and fix the shooting element, forming a vertical focusing drive unit; the rotating bracket 21 of the overall rotation mechanism 2 is connected to the angle adjustment mechanism 3 through the arc-shaped rack and pinion guide rail 23 to realize coordinated position adjustment in the horizontal circumferential and pitch angle dimensions.

[0039] To achieve self-calibration, the intraocular pressure measurement calibration device of the present invention preferably includes a self-calibration unit; the lifting and focusing mechanism 1, the overall rotation mechanism 2, and the angle adjustment mechanism 3 are all communicatively connected to the self-calibration unit.

[0040] Specifically, the self-calibration unit of this invention preferably includes an automatic interference fringe region cropping module, a focusing position calculation module, an overall rotation direction angle calculation module, and an angle recognition and closed-loop calibration module. The automatic interference fringe region cropping module is used to preprocess the acquired image, removing invalid background areas and retaining the effective imaging area of ​​the sensor, thereby improving the accuracy and computational efficiency of subsequent algorithms. A specific implementation method can be as follows: read the original interference fringe image acquired by the external imaging module 42, convert the image to a grayscale image, and perform edge detection using the Canny operator; extract the effective region contours in the image through contour retrieval, calculate the area of ​​each contour, and select the smallest bounding rectangle corresponding to the contour with the largest area, thus completing the automatic cropping of the sensor interference region; uniformly scale the cropped image to a standard size of 224×224 to provide standardized input for subsequent angle recognition and attitude correction.

[0041] The lifting and focusing position calculation module is used to achieve fully automatic and precise focusing of the interference fringe image, ensuring that the fringes are clear, complete, and blur-free. The module controls the lifting drive motor 11 to drive the imaging unit 4 to move linearly along the optical axis, acquiring multiple frames of images throughout the entire stroke and evaluating their sharpness, automatically positioning itself to the optimal focal length. Specifically, the lifting drive motor 11 drives the screw shaft 13 to rotate, causing the anti-rotation sleeve 14 and the external imaging module 42 to move linearly up and down along the optical axis, continuously acquiring multiple frames of interference fringe images with different focal lengths throughout the entire stroke; the sharpness of each frame is evaluated, and the focal length position corresponding to the maximum sharpness index is selected; the lifting and focusing mechanism 1 is driven to automatically position itself to the optimal focal length, completing automatic focusing and providing high-quality, clear images for subsequent attitude correction and angle recognition.

[0042] The overall rotation direction angle calculation module is used to calculate the deflection angle of the interference fringes, output the rotation direction and rotation angle, and realize the coarse calibration of the image attitude. Specifically, the implementation can be as follows: input the autofocused interference fringe image into the preprocessing module to complete region cropping and grayscale processing; calculate the brightness-weighted centroid coordinates of the image, and establish a vector relationship between the centroid and the reference point with the geometric center of the image as the reference point; calculate the brightness principal direction angle of the current interference fringe using the arctangent function, compare it with the preset standard direction, obtain the required rotation angle, and normalize it to the [-180°, 180°] range; output clockwise or counterclockwise rotation commands and corresponding angle values ​​based on the calculation results, drive the overall rotation mechanism 2 to perform circumferential rotation, complete the coarse adjustment of the interference fringe image attitude, so that the subsequent angle adjustment mechanism 3 only needs to complete the fine calibration along a single direction.

[0043] The angle recognition and closed-loop calibration module employs a dual-output convolutional neural network, including both angle classification and angle regression branches, to achieve incident angle grouping and continuous numerical output, and completes closed-loop calibration according to a hierarchical adjustment strategy. The module achieves high-precision incident angle recognition based on the convolutional neural network and drives the angle adjustment mechanism 3 to complete micro-angle closed-loop correction. Specifically, the angle recognition and closed-loop calibration module achieves high-precision incident angle recognition based on the convolutional neural network and drives the angle adjustment mechanism 3 to complete micro-angle closed-loop correction. See also... Figure 8 As shown, the specific implementation can be as follows: Construct a dual-output convolutional neural network model based on a lightweight ResNet18 backbone. The model includes both an angle classification branch and an angle regression branch. The classification branch divides the incident angle into three groups: 0°-5°, 6°-9°, and ≥10°. The regression branch outputs continuous and accurate incident angle values. Establish an interference fringe image dataset, group it according to the incident angle, and jointly optimize the model parameters using the cross-entropy loss function and the mean square error loss function. Input the coarsely corrected interference fringe images into the trained network model, which outputs the incident angle groupings and accurate angle values. Based on the output incident angle groupings... The system executes a graded adjustment strategy to achieve precise closed-loop calibration by determining the precise angle value. If the incident angle is ≥10°, the angle adjustment mechanism is adjusted by 10° at a time. After adjustment, the interference fringe image is reacquired and input into the model for judgment. If the incident angle is 6°-9°, the angle adjustment mechanism is adjusted by 5° at a time. After adjustment, the interference fringe image is reacquired and input into the model for judgment. If the incident angle is 0°-5°, no angle adjustment is required, and the current angle is deemed to meet the calibration requirements. Through the above graded adjustment logic, the angle adjustment motor 32 is driven, causing the gear 33 to mesh and roll along the arc-shaped rack guide rail 23. This drives the connecting plate 31 and the external imaging module 42 to perform micro-angle pitch adjustment, gradually correcting the incident light angle to near 0°, ensuring that the light is strictly perpendicularly incident on the surface of the FP microcavity sensitive diaphragm, thus meeting the optical requirements of Fabry-Perot interference.

[0044] This invention employs a three-level collaborative closed-loop control logic of "baseline focusing → circumferential coarse rotation → angle fine adjustment": First, the image clarity is optimized through the lifting and focusing mechanism 1; second, the fringe posture is standardized and corrected through the overall rotation mechanism 2; and finally, the incident light is vertically calibrated through angle recognition and micro-angle adjustment. The three are executed sequentially and feedback is closed, ultimately achieving fully automatic, standardized, and high-precision acquisition of interference fringe images, which significantly improves the measurement stability and detection accuracy of the implantable intraocular pressure monitoring system.

[0045] The intraocular pressure measurement calibration device provided by this invention achieves fully automated calibration of focal length, direction, and angle through mechanism-coordinated closed-loop control and intelligent image processing algorithms, eliminating the need for manual intervention and significantly reducing operational difficulty. It is compatible with clinical applications of implantable intraocular pressure monitoring systems. Through step-by-step calibration involving image clarity optimization, fringe posture correction, and incident optical axis alignment, it effectively solves problems such as poor interference fringe quality and difficulty in demodulation in existing technologies, significantly improving the accuracy and data consistency of intraocular pressure measurement. The device has a compact structure, strong compatibility, and can be used with existing implantable intraocular pressure sensors and image processing systems, demonstrating significant clinical application value.

[0046] This invention achieves automatic focal length adjustment through a lifting and focusing mechanism 1, coarse correction of interference fringe attitude through an overall rotation mechanism 2, and precise alignment of the incident light at a micro-angle through an angle adjustment mechanism 3. Combined with interference fringe clipping, automatic focusing, orientation angle calculation, and angle closed-loop calibration algorithms, a three-level collaborative calibration system is formed. This invention can automatically complete integrated calibration of focal length, orientation, and incident angle without manual intervention, significantly improving the imaging quality of interference fringe and the accuracy of intraocular pressure measurement. Its compact structure and strong adaptability meet the portability, high precision, and clinical application requirements of implantable intraocular pressure monitoring systems.

[0047] This invention provides a self-calibration device for intraocular pressure measurement. Through mechanism coordination and algorithm support, it achieves standardized acquisition of interference fringe images, which solves the defects of existing implantable intraocular pressure monitoring systems, such as insufficient measurement accuracy and complex operation procedures due to the lack of a self-calibration link. It can meet the clinical application needs of implantable intraocular pressure monitoring systems.

[0048] Another object of the present invention is to provide an intraocular pressure measurement calibration method, which performs intraocular pressure measurement calibration using the intraocular pressure measurement calibration device described above.

[0049] Specifically, the intraocular pressure measurement calibration method includes the following steps: Obtain the original interference fringe image; The original interference fringe image is preprocessed to obtain the effective imaging region; The optimal focus position is determined and located based on the sharpness of multiple frames of images at different focal lengths. Calculate the deflection angle of the interference fringes and output a rotation command to complete the coarse attitude calibration. Based on the convolutional neural network to identify the incident angle, hierarchical micro-angle closed-loop correction is performed according to the incident angle to correct the incident light to near 0° vertical incidence, and the calibration is completed.

[0050] Specifically, this invention uses an automatic interference fringe region cropping module for image preprocessing to remove invalid background and retain the effective imaging area of ​​the sensor; a focus adjustment position calculation module is used to acquire multiple frames of images with different focal lengths, evaluate sharpness, and locate the optimal focus position; an overall rotation direction angle calculation module is used to calculate the interference fringe deflection angle and output rotation commands to complete coarse attitude calibration; and an angle recognition and closed-loop calibration module uses a convolutional neural network to recognize the incident angle, drives the angle adjustment mechanism to perform hierarchical micro-angle closed-loop correction, corrects the incident light to near 0° vertical incidence, and completes the calibration.

[0051] The intraocular pressure measurement calibration method provided by this invention can be performed according to the process described above, and will not be repeated here.

[0052] Based on the above-described preferred embodiments of the present invention, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the inventive concept. The technical scope of this invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. An intraocular pressure measurement and calibration device, characterized in that, It includes a lifting and focusing mechanism (1), an overall rotation mechanism (2), and an angle adjustment mechanism (3); wherein, one end of the lifting and focusing mechanism (1) is connected to the shooting unit (4), and the other end is connected to the angle adjustment mechanism (3); the angle adjustment mechanism (3) is engaged with the overall rotation mechanism (2).

2. The intraocular pressure measurement and calibration device as described in claim 1, characterized in that, The overall rotating mechanism (2) includes a rotating bracket (21), a rotating drive motor (22), and an arc-shaped rack and pinion guide rail (23); the output shaft of the rotating drive motor (22) is coaxially connected to the rotating bracket (21) via a coupling; the rotating bracket (21) is fixedly connected to the arc-shaped rack and pinion guide rail (23); the overall rotating mechanism (2) is meshed with the angle adjustment mechanism (3) via the arc-shaped rack and pinion guide rail (23).

3. The intraocular pressure measurement and calibration device as described in claim 1, characterized in that, The angle adjustment mechanism (3) includes a connecting plate (31), an angle adjustment motor (32), and a gear (33); the output shaft of the angle adjustment motor (32) is coaxially connected to the center hole of the gear (33); the gear (32) is fixedly connected to the connecting plate (31); the angle adjustment mechanism (3) is connected to the lifting and focusing mechanism (1) through the connecting plate (31); the angle adjustment mechanism (3) is meshed with the overall rotating mechanism (2) through the gear (33).

4. The intraocular pressure measurement and calibration device as described in claim 3, characterized in that, The angle adjustment mechanism (3) further includes a number of rollers (34); the angle adjustment mechanism (3) is tumblingly connected to the overall rotating mechanism (2) through the number of rollers (34); the number of rollers (34) is even.

5. The intraocular pressure measurement and calibration device as described in claim 4, characterized in that, The number of rollers (34) is four.

6. The intraocular pressure measurement and calibration device as described in claim 1, characterized in that, The lifting and focusing mechanism (1) includes a lifting drive motor (11), a support ear (12), and a screw shaft (13); one end of the screw shaft (13) is connected to the support ear (12) through a bearing, and the other end is connected to the shooting unit (4); the lifting and focusing mechanism (1) is connected to the angle adjustment mechanism (3) through the support ear (12); the output shaft of the lifting drive motor (11) is coaxially connected to the screw shaft (13) through a coupling.

7. The intraocular pressure measurement and calibration device as described in claim 6, characterized in that, The lifting and focusing mechanism (1) also includes an anti-rotation sleeve (14) and a guide post (15); the screw shaft (13) is provided with an external thread, the anti-rotation sleeve (14) is provided with a through hole (141), and the through hole (141) is provided with an internal thread that is compatible with the external thread; the screw shaft (13) and the anti-rotation sleeve (14) are engaged by the external thread and the internal thread to form a screw nut transmission pair; one end of the guide post (15) is fixedly connected to the support ear (12), and the other end is inserted into the anti-rotation sleeve (14).

8. The intraocular pressure measurement and calibration device as described in claim 7, characterized in that, The number of guide posts (15) is two.

9. The intraocular pressure measurement and calibration device according to any one of claims 1-8, characterized in that, It also includes a self-calibration unit; the lifting and focusing mechanism (1), the overall rotation mechanism (2) and the angle adjustment mechanism (3) are all communicatively connected to the self-calibration unit.

10. A method for calibrating intraocular pressure measurement, characterized in that, Intraocular pressure measurement calibration is performed using the intraocular pressure measurement calibration device as described in any one of claims 1-9; The intraocular pressure measurement calibration method includes the following steps: Obtain the original interference fringe image; The original interference fringe image is preprocessed to obtain the effective imaging area; The optimal focus position is determined and located based on the sharpness of multiple frames of images at different focal lengths. Calculate the deflection angle of the interference fringes and output a rotation command to complete the coarse attitude calibration. Based on the convolutional neural network to identify the incident angle, hierarchical micro-angle closed-loop correction is performed according to the incident angle to correct the incident light to near 0° vertical incidence, and the calibration is completed.

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