Artificial hair mammilla substition structure and its manufacturing method

Abstract

An artificial hair papilla for treating the hypotrichosis and alopecia is composed of the hair papilla cells and a three-layer hollow microbag consisting of sodium alginate, polylsine and sodium alginate layers for containing said hair papilla cells in it.

Description

technical field

[0001] The invention belongs to a human body or animal tissue replacement structure and a manufacturing method thereof, in particular to an artificial hair papilla replacement structure and a manufacturing method thereof. Background technique

[0002] The dermal papilla of humans or animals is located at the bottom of the hair follicle, including dermal papilla cells 2 and basement membrane 3 (see figure 1 ). Studies and experiments have confirmed that the dermal papilla plays an important core role in inducing hair follicle regeneration and maintaining hair growth. One of the important mechanisms is that the dermal papilla continuously secretes and transmits relevant signal factors to the hair follicle during this process. However, if the dermal papilla cells are transplanted into the skin alone, the effect of inducing hair follicle regeneration and maintaining hair growth is very unstable. The papilla cells provide a three-dimensional growth space, allowi...

Examples

Embodiment 1

[0028] See figure 2, the artificial hair papilla replacement structure of this embodiment includes a hollow microcapsule 1, the hollow microcapsule is a sodium alginate-polylysine-sodium alginate three-layer semipermeable membrane structure, the diameter of the microcapsule is 300 μm, and the microcapsule The wall thickness of the microcapsule is 4 μm, and 15 human scalp dermal papilla cells 2 are initially wrapped in the microcapsule. Of course, the number of cells can gradually grow and increase in the future.

Embodiment 2

[0030] The artificial hair papilla replacement structure of this embodiment comprises a hollow microcapsule of sodium alginate-polylysine-sodium alginate three-layer structure membrane, the diameter of the microcapsule is 500 μm, and the wall thickness of the microcapsule is 8 μm. 40 human scalp dermal papilla cells are wrapped, and its structure is basically the same as that of Example 1.

Embodiment 3

[0032] The artificial hair papilla replacement structure of this embodiment comprises a hollow microcapsule of a sodium alginate-polylysine-sodium alginate three-layer structure membrane, the diameter of the microcapsule is 400 μm, and the wall thickness of the microcapsule is 6 μm. 25 human scalp dermal papilla cells are wrapped, and its structure is basically the same as that of Example 1.

technical field

[0001] The invention belongs to a human body or animal tissue replacement structure and a manufacturing method thereof, in particular to an artificial hair papilla replacement structure and a manufacturing method thereof. Background technique

[0002] The dermal papilla of humans or animals is located at the bottom of the hair follicle, including dermal papilla cells 2 and basement membrane 3 (see figure 1 ). Studies and experiments have confirmed that the dermal papilla plays an important core role in inducing hair follicle regeneration and maintaining hair growth. One of the important mechanisms is that the dermal papilla continuously secretes and transmits relevant signal factors to the hair follicle during this process. However, if the dermal papilla cells are transplanted into the skin alone, the effect of inducing hair follicle regeneration and maintaining hair growth is very unstable. The papilla cells provide a three-dimensional growth space, allowi...

Examples

Embodiment 1

[0028] See figure 2, the artificial hair papilla replacement structure of this embodiment includes a hollow microcapsule 1, the hollow microcapsule is a sodium alginate-polylysine-sodium alginate three-layer semipermeable membrane structure, the diameter of the microcapsule is 300 μm, and the microcapsule The wall thickness of the microcapsule is 4 μm, and 15 human scalp dermal papilla cells 2 are initially wrapped in the microcapsule. Of course, the number of cells can gradually grow and increase in the future.

Embodiment 2

[0030] The artificial hair papilla replacement structure of this embodiment comprises a hollow microcapsule of sodium alginate-polylysine-sodium alginate three-layer structure membrane, the diameter of the microcapsule is 500 μm, and the wall thickness of the microcapsule is 8 μm. 40 human scalp dermal papilla cells are wrapped, and its structure is basically the same as that of Example 1.

Embodiment 3

[0032] The artificial hair papilla replacement structure of this embodiment comprises a hollow microcapsule of a sodium alginate-polylysine-sodium alginate three-layer structure membrane, the diameter of the microcapsule is 400 μm, and the wall thickness of the microcapsule is 6 μm. 25 human scalp dermal papilla cells are wrapped, and its structure is basically the same as that of Example 1.

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